|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-360 |
8.60e-55 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 183.92 E-value: 8.60e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 1 MRKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYS 80
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 81 LSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYA 159
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 160 FLALSMLSLAIGIAltfavrgevskpsrvrfsiprNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLL 238
Cdd:COG2271 167 FLILGLPGLLLALL---------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 239 SVIGITGSLVGGGLYDRIGRRS---VAVVFGLNALLTLILALTASPWVIIPL----GITFYSVGAIVTAYTSEKATGENL 311
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGRRRklvLAIGLLLAALALLLLALLPSPALAIALlflaGFGLGGAFGLLWALAAELFPKKAR 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1900934710 312 GSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
2-360 |
1.35e-44 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 156.96 E-value: 1.35e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 LALSMLSLAIGIALTFAVrgevskpsrvrfsipRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLS 239
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL---------------RQVWGLALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 240 VIGITGSLVGGGLYDRI---GRRSVAVVFGLNALLTLILALTA-SPWVIIPL----GITFYSVGAIVTAYTSEKATGENL 311
Cdd:cd17319 226 LAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTtSPVVAVILlslaGFGIGAASPVFWSLPADLLPGEAA 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1900934710 312 GSVMGFVNMVGFFGATVGPYAVGLLIDHFG-YEKAFLSIPAMYLLAGVLV 360
Cdd:cd17319 306 ATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLV 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-360 |
4.27e-42 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 151.19 E-value: 4.27e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 LALSMLSLAIGIALTFAVR---GEVSKPSRVRFSIPRNVF------LLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKT 230
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRdppAGAAAAAKASLRDQLEALrdprfwLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 231 ASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGLNALLTLILALTASP------WVIIPLGITFYSVGAIVTAYTSE 304
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGslwlflVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1900934710 305 KATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFG-YEKAFLSIPAMYLLAGVLV 360
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLT 379
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-341 |
9.01e-38 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 139.62 E-value: 9.01e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 22 AIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRAL 101
Cdd:COG2807 36 SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 102 YGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFAVRGE 181
Cdd:COG2807 116 IGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 182 VSKPSRVRFSIP-------RNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYD 254
Cdd:COG2807 196 PAAAAAAPAAASlrslwrsPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 255 RIGRRSVAVVFGLNALLTLILALTASPWVIIPLGITFYSVG-----AIVTAYTSEKA-TGENLGSVMGFVNMVGFFGATV 328
Cdd:COG2807 276 RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGqgglfPLALTLIGLRArTPAEAAALSGMAQSVGYLLAAL 355
|
330
....*....|...
gi 1900934710 329 GPYAVGLLIDHFG 341
Cdd:COG2807 356 GPLLVGALHDATG 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-328 |
2.19e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 134.72 E-value: 2.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 LALSMLSLAIGIALTFAVR-GEVSKPSRVRFSIP-----RNVFLLSAANFIVLAAFFGLLTFLVSFLVN-SGVSLKTASL 233
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPeSRPAARARLRGSLRellrrPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 234 LFSLLSVIGITGSLVGGGLYDRIGRRSVAVV-FGLNALLTLILALTASPWVIIP----LGITFYSVGAIVTAYTSEKATG 308
Cdd:COG2814 248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIgLLLLALGLLLLALAGSLWLLLLalflLGFGFGLLFPLLQALVAELAPP 327
|
330 340
....*....|....*....|
gi 1900934710 309 ENLGSVMGFVNMVGFFGATV 328
Cdd:COG2814 328 EARGRASGLYNSAFFLGGPL 347
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-360 |
1.99e-34 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 129.98 E-value: 1.99e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 23 IPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALY 102
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 103 GLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIaVNLEWRYAFLALSMLSLAIGIALTFAVR--- 179
Cdd:cd17478 95 GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL-VALFGGLGLLILLIIPGLAVALLLLRLRplk 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 180 -------GEVSKPSRVRFSIPRNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGL 252
Cdd:cd17478 174 kpeakkaAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 253 YDRIGRRSVAVVFGLNALLTLILALTASPWVIIPL----GITFYSVGAIVTAYTSEKAtGENLGSVMGFVNMVGFFGATV 328
Cdd:cd17478 254 SDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILlvlaGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGI 332
|
330 340 350
....*....|....*....|....*....|..
gi 1900934710 329 GPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17478 333 GAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-360 |
1.19e-33 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 128.08 E-value: 1.19e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 21 MAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRA 100
Cdd:cd17325 13 GIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 101 LYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFAVR 179
Cdd:cd17325 93 LQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 180 GEVSKPSRVRFSI------------PRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGS 246
Cdd:cd17325 173 EPRPPPNKRAVSAarlrsglrlllrDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 247 LVGGGLYDRIGRRSVAVVFGLNALLTLILALTASPWVIIPLGITFYSVG-----AIVTAYTSEKATGENLGSVMGFVNMV 321
Cdd:cd17325 253 PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGlglvfPATLALLADIVPPEGRGTAMGLFNTA 332
|
330 340 350
....*....|....*....|....*....|....*....
gi 1900934710 322 GFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17325 333 FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-360 |
2.28e-31 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 121.89 E-value: 2.28e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 21 MAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRA 100
Cdd:cd17324 16 YVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 101 LYGLFSGLYYAPATALISE-VYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFAVR 179
Cdd:cd17324 96 LAGLAHGGFWAIAAAYAADlVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 180 GEVSKPSRVRFSI--------PRNVFLLSAANFIVLAAFFGLLTFLVSFLVN-SGVSLKTASLLFSLLSVIGITGSLVGG 250
Cdd:cd17324 176 SLPPKKPGSLGLLsslllllrNPRLRLAYLITFLLFGGFFALYTYLAPFLTDvPGFSSSAIIGLLLLFGVAGVVGSPLAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 251 GLYDRIGRRSVAVVFGLNALLTLILALTASPWV-----IIPLGITFYSVGAIVTAYTSEKAtGENLGSVMGFVNMVGFFG 325
Cdd:cd17324 256 RLADRGGRRALLIALLLLAAALLLLTLLGPSPLlllvgLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLG 334
|
330 340 350
....*....|....*....|....*....|....*
gi 1900934710 326 ATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17324 335 GALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-362 |
2.23e-30 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 119.21 E-value: 2.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 23 IPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALY 102
Cdd:cd17474 18 VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 103 GLFSGLYYAPATALISEVYRERK-GSALGVFMVGPPVGSGIAPLIVVPIAvNLEWRYAFLALSMLSLAIGIALTFAVRGE 181
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGErAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 182 VSKPSRVRFSI---------PRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGG 251
Cdd:cd17474 177 KEKAKSSSATKlrdlkkalrGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 252 LYDRIGRRSVAVVFGLNALLTLILALTASP---WVIIPLGITFYSVGAIVTAYTS---EKATGENLGSVMGFVNMVGFFG 325
Cdd:cd17474 257 LLKKRFGARRILVIGLLLYALSLLLLGFVPslaLLLIAIVLFGLGLGLNLPLLTTlvtELAPEEERGTASSLYNFVRFLG 336
|
330 340 350
....*....|....*....|....*....|....*..
gi 1900934710 326 ATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLVKL 362
Cdd:cd17474 337 QAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-359 |
1.01e-28 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 114.95 E-value: 1.01e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIV---VPIAVNLEWRY 158
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGgllILLGLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 159 AFLALSMLSLAIGIALTFA---VRGEVSKPSRVRFSIPRNVFLLSAANFIVLAAFF------GLLTFLVSFLVNS-GVSL 228
Cdd:COG0738 166 PYLILAVLLLLLALLFLRSklpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLyvgaegAIGDWLPLYLKDVlGLSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 229 KTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGLNALLTLILALTASPWVIIPLGITFYSVGA-----IVTAYTS 303
Cdd:COG0738 246 ATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLslmfpTIFSLAL 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1900934710 304 EkATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVL 359
Cdd:COG0738 326 D-GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
6-359 |
1.88e-28 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 114.26 E-value: 1.88e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 6 LLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSAL 85
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 86 IVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIApLIV--VPIAVNLEWRYAFLA 162
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFpKEKRTRALGVFYFAIPLGSGLG-YVVggLVAQATGGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 163 LSMLSLAIGIALTFAVR--------GEVSKPSRV-------RFSIPRNVFLLSAANFIVLA------AFFGlLTFLVSFL 221
Cdd:cd17328 160 TGVLGVLLAILLLLFVRepprgaaeGGVMAKSTAtsfladlKALAKNPSFILSTLGFTAVSfvtgalAFWA-PTFFLRAF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 222 VNSGVSLKTASLLFSLLSVI-GITGSLVGGGLYDRIGRR------------SVAVVFGLNALLTLILALTASPWVIIPLG 288
Cdd:cd17328 239 GVGDLSSADVGLIFGAITCIaGVLGVLLGGILADRLRRKtpradplvcavgLLAAAPFLFLALVLALSNLLLAWVLLFLG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 289 ITFYSVG-AIVTAYTSEKATGENLGSVMGFVN-MVGFFGATVGPYAVGLLIDHFGY------------EKAFLSIPAMYL 354
Cdd:cd17328 319 EFLLSLNwAPVFAILLYVVIPTRRSTASAIQIlLSHLLGDAGSPYLIGLISDLLRQnkdsplaeaaslQYALLLCSFVLV 398
|
....*
gi 1900934710 355 LAGVL 359
Cdd:cd17328 399 LGGFF 403
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
2-360 |
5.62e-28 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 112.37 E-value: 5.62e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 LALSMLSLAIGIALTFAVRGEvskpsrvrfsiPRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLS 239
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDS-----------PPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVkGYSLIDAGWFSSLYE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 240 VIGITGSLVGGGLYDRI--GRRSVAVVF---GLNALLTLILALTASPWVIIPLGITF-YSVGA----IVTAYTSEKATGE 309
Cdd:cd17312 230 VGGIAGTILAGLLSDKLfgGRRAPIAVIymlLMTLSLALFWFFPHNKLLSIVLLFLIgFFVGGpinlIGGAAAQDIGRKE 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1900934710 310 NLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17312 310 AAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLL 360
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
21-361 |
1.08e-27 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 111.95 E-value: 1.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 21 MAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRA 100
Cdd:cd17475 13 QGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 101 LYGLFSGLYYAPATALISEVYRER-KGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTF--- 176
Cdd:cd17475 93 LVGAGYGSVQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLfyr 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 177 ---AVRGEVSKPSRVRFSIP-----RNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSL 247
Cdd:cd17475 173 eppAASAATESASTLLRSLKevlrnRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 248 VGGGLYDRI--GRRSVAVVF----GLNALLTLILALTASPWVIIPLGITFYSVGAI-----VTAYTSEKATGENLGSVMG 316
Cdd:cd17475 253 GLGRVSDRVfgGRRRPVLVItaaiAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIgwnglYLTLVAESAGPEQAGTALG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1900934710 317 FVNMVGFFGATVGPYAVGLLIDH-FGYEKAFLSIPAMYLLAGVLVK 361
Cdd:cd17475 333 LANTINFIGIAIGPPLFGLLVDAtHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
11-358 |
1.33e-27 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 111.63 E-value: 1.33e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 11 LGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAR 90
Cdd:cd17371 6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 91 EYWELLAVRALYGLFSGLYYAPATALISEVYRER-KGSALGVFMVGPPVGSGIAPL---IVVPIAVNLE-WRYAFlalsm 165
Cdd:cd17371 86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARhRGKALGYVQSGWAVGWLLATLlaaLLFPLLPPEIaWRVLF----- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 166 LSLAIGIALTFAVRGEVSKPSRV------------RFSIP-------RNVFLLSAANFI-VLAAFFGLLTFLVSFLVNS- 224
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWqaaraarrhfadRPSLRelfspplLRTTLLASLLATgALGGYYGITTWLPSYLTGEr 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 225 GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVF--GLNALLTLILALTASP----WVIIPLGITFYSVGAIV 298
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFalGSAISILLYFFLPLSPtlilILGFPLGFFASGPFSGM 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 299 TAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGV 358
Cdd:cd17371 321 GAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGL 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-330 |
1.73e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 110.59 E-value: 1.73e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 8 LVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIV 87
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 88 FAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSML 166
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 167 SLAIGIALTFAVRGEVSKPSRVRFSIP------------RNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLL 234
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARlslivawkallrDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 235 FSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGLNALLTLILALTASP--------WVIIPLGITFYSVGAIVTAYTSEKA 306
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlsslwllLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 1900934710 307 TGENLGSVMGFVNMVGFFGATVGP 330
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
26-360 |
1.09e-24 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 103.05 E-value: 1.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 26 LIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLF 105
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 106 SGLYYAPATALISE-VYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALtfavrgevsk 184
Cdd:cd17365 101 LGAAMPNAITLVSEyAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLL---------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 185 psrvrfsipRNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIG-RRSVAV 263
Cdd:cd17365 171 ---------RGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGpKRVLAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 264 VFGLNALLTLILALTASPWV-----IIPLGITFYSVGAIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLID 338
Cdd:cd17365 242 FFALGAVSLALLGVSPASLVllyvlVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLA 321
|
330 340
....*....|....*....|...
gi 1900934710 339 -HFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17365 322 aGLGPESVFLALAIPAALGALAV 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-359 |
1.60e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 100.19 E-value: 1.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 9 VSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVF 88
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 89 AREYWELLAVRALYGLFSGLYYAPATALISEVYRER-KGSALGVFMVGPPVGSGIAPLIVVPIAVNLE--WRYAFLALSM 165
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGfgWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 166 LSLAIGIALTFAVRGEVSKPSRVRFSIP--------------RNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGV-SLKT 230
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASsksvlkllkrvlknPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 231 ASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGLNALLTLILALTASP------WVIIPLGITFYSVGAIVTAYTSE 304
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPslllllLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1900934710 305 KATGENLGSVMGFVNMVGFFGATVGPYAVGLLID-HFGYEKAFLSIPAMYLLAGVL 359
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
6-360 |
1.94e-23 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 99.60 E-value: 1.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 6 LLLVSLGWVFNYAHRMAIPPLIPMIKAE--LGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSS 83
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 84 ALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGVFM-----VGPPVGSGIAPLIVVPIAVNLEWRY 158
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwaLGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 159 AFlalsmLSLAIGIALTFAVRgevskpsrvrfsipRNVFLLSAANFIVLAAFFGLLTFLVSFLV-NSGVSLKTASLLFSL 237
Cdd:cd17316 161 LF-----LIGALPALLALLLR--------------RRTLLLILLWFFISFGYYGLTTFLPTYLQtVLGLSPATSSLYLLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 238 LSVIGITGSLVGGGLYDRIGRRSVAVVF---GLNALLTLILALTASPWVIIPLGITFYSVGAIVT----AYTSEKATGEN 310
Cdd:cd17316 222 ISLGALVGALIAGLLSDRIGRKKTLVIGlilSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWgalyAYLAELFPTEV 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1900934710 311 LGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17316 302 RATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
4-360 |
1.51e-22 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 97.34 E-value: 1.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 4 RLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSS 83
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 84 ALIVFAREYWELLAVRALYGLF--SGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFL 161
Cdd:cd17355 83 VLLALATSLWQLYLLWGLLGGGgaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 162 ALSMLSLAIGIALTFAVRGEVSKPSRVRFSIP---------------RNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGV 226
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDAspaspgstlkealrsASFWLLALAFFLCGFAVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 227 SLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFgLNALLTLILALTASPWVIIPL-------GITFYSVGAIVT 299
Cdd:cd17355 243 SPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAAS-YALRALGLALLLLLPFPPLALllfaalfGLGWGATVPLTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1900934710 300 AYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFG-YEKAFLSIPAMYLLAGVLV 360
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLV 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-340 |
1.64e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 94.16 E-value: 1.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 21 MAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRA 100
Cdd:cd17321 13 TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 101 LYGLFSGLYYAPATALISEVYR-ERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLalsmLSLAIGIALTFAVr 179
Cdd:cd17321 93 LQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL----INVPIGLVALLLA- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 180 gevskpsrvrfsipRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGR 258
Cdd:cd17321 168 --------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVlGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 259 RSVAV---VFGLNALLTLILALTASPWVIIPLGITFYSVG-----AIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGP 330
Cdd:cd17321 234 RLVLVaglLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGlglfaTPLTNAALSSVPKEKAGAASGILNTARQLGGALGV 313
|
330
....*....|
gi 1900934710 331 YAVGLLIDHF 340
Cdd:cd17321 314 ALLGALLTAG 323
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-360 |
4.91e-21 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 93.02 E-value: 4.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 22 AIPPLIPMIKAELGINNAE-AGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRA 100
Cdd:cd17473 17 AIAPALPAIAQHFVPNSELlVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 101 LYGLFSGLYYAPATALISEVYR-ERKGSALGVFMVGPPVGSGIAPLIVVPIAvNLEWRYAFLALSmLSLAIGIALTFAVR 179
Cdd:cd17473 97 LLGIGVAGIMTLATALIGDYFEgEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL-LALPVLILVLLFLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 180 GEVSKPSRVRFSI--------PRNVFLLSAANFIVLAAFFGLLTFLVSFLVNSG-VSLKTASLLFSLLSVIGITGSLVGG 250
Cdd:cd17473 175 EPARKSKSAASPGaataaalpWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 251 GLYDRIG-RRSVAVVFGLNALLTLILALTASPWVIIP----LGITFYSVGAIVTAYTSEKATGENLGSVMGFVNMVGFFG 325
Cdd:cd17473 255 RLKRRLGkRRLLAIGFALMALGFLLLALASGLWVVLLgailAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
330 340 350
....*....|....*....|....*....|....*
gi 1900934710 326 ATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17473 335 QFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIV 369
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-337 |
1.36e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 86.26 E-value: 1.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 3 KRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLS 82
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 83 SALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRER-KGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFL 161
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRfRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 162 ALSMLSLAIGIALTF-----AVRGEVSKPSRVRFSIP-------------------------------------RNVFLL 199
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRflpesIDFLVSKRPETVRRIVNaiapqmqaeaqsalpeqkstqgtkrsvfkalfqgktaRITVLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 200 SAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVF-GLNALLTLILALT 278
Cdd:TIGR00895 256 WLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLlLGAVFAVLVGSTL 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1900934710 279 ASPWVIIPLG--ITFYSVGAIVT--AYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLI 337
Cdd:TIGR00895 336 FSPTLLLLLGaiAGFFVNGGQSGlyALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
7-360 |
1.73e-18 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 85.68 E-value: 1.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 7 LLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALI 86
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 87 VFA--REYWELLAVRALYGLFSGLYYAPATALISE-VYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLAL 163
Cdd:cd17380 82 PLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRwVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 164 SMLSLAIGIALTFAVRGevskpsrvrfsiprnVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGI 243
Cdd:cd17380 162 GLLGLLWALVWLIYLPP---------------VWAIIVAHFCMNWGFYILLSWLPTYFHEVLVPLAKGWVFNVVPWLVMF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 244 TGSLVGGGLYDRIGRRSVAVV----------FGLNALLTLILALTASPWviipLGITFYSVGAIVTAYTSEKAT------ 307
Cdd:cd17380 227 PSSNVAGWLADHLISRGWTVTsvrklmqsigFLGPALFLLLLSHTDSFS----LALLCMSVALGLSAFSSSGVLvnhqdi 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1900934710 308 -GENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17380 303 aPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVV 356
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-362 |
2.23e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 85.34 E-value: 2.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL 104
Cdd:cd17489 17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 105 -FSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLaLSMLSLAIGIALTFAVRGEVS 183
Cdd:cd17489 97 gWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFI-VAAVLALLALLLVFLVKDPPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 184 KP-------SRVRFSIPRNVFLLSAANFIVLA-AFFGLLTFLVSFLVNSGVSlkTASLLFSLLSVIGITGSLVGGGLYDR 255
Cdd:cd17489 176 VAaeeaeagTRAFRRLVEKKVLPPALILFLASiAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 256 IGRRSVAVV-FGLNALLTLILALTASPWVI----IPLGITFYSVGAIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGP 330
Cdd:cd17489 254 KGPKTVIIPgLLLLALGLLLLSFAGSPWMLllaaVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGG 333
|
330 340 350
....*....|....*....|....*....|..
gi 1900934710 331 YAVGLLIDHFGYEKAFLSIPAMYLLAGVLVKL 362
Cdd:cd17489 334 LLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
2-359 |
7.39e-18 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 83.61 E-value: 7.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYsRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 LALSMLSLAIGIALTFAVRGEvskpsrvrfsiPRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLS 239
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDR-----------PPYIWLLAFCYVLVYVVRTAINDWGNLYLSEThGYSLVKANSAVSLFE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 240 VIGITGSLVGGGLYDRI---GRRSVAVVFGLNALLTLILALTASPWVIIPLGITFYSVG----------AIVTAYTSEKA 306
Cdd:cd17488 230 VGGLIGALVAGWGSDKLfkgNRGPMNLIFALGLLVSVGALWLVPVHSYWLLATCFFTIGffvfgpqmliGMAAAECSHKD 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1900934710 307 TGenlGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVL 359
Cdd:cd17488 310 AA---GSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLL 359
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-266 |
4.21e-17 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 80.63 E-value: 4.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 LALSMLSLAIGIALTFAVRGEVSKPSRVRFSIPRNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSV 240
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260
....*....|....*....|....*.
gi 1900934710 241 IGITGSLVGGGLYDRIGRRSVAVVFG 266
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLA 277
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
11-346 |
6.82e-17 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 80.88 E-value: 6.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 11 LGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAR 90
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 91 EYWELLAVRALYGLFSGLYYAPATALISEVYRERK-GSALGVFMVGPPVGSGIAPLIV-VPIAVNLEWRYAFLALSMLSL 168
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSErGTWVSFWNCSHNVGGGLLPPLVlFGIAELYSWHWVFIVPGIIAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 169 AIGIALTFAVRG----------------------EVSKPSRVRFSI-------PRNVFLLSAANFIVLAAFFGLLTFLVS 219
Cdd:TIGR00881 162 IVSLICFLLLRDspqscglppaeempneepdgdaEKKEEELTKKQIflqyvllNKVLWYISLGYVFVYVVRTGILDWSPL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 220 FLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRI---GRRSVAVVFGLNALLTLIL---ALTASPWVIIPLGITF- 291
Cdd:TIGR00881 242 YLTQEkGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVywlNPAANPLMDLICLFALg 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1900934710 292 ---YSVGAIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAF 346
Cdd:TIGR00881 322 flvYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
25-360 |
6.99e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 78.00 E-value: 6.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL 104
Cdd:cd17320 20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 105 FSGLYYAPATALISEVYRERKGSAL-----GVFMVGPpvgsGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTF--- 176
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSGAELAKIfsllmMILAIAP----ALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLflp 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 177 --AVRGEVSKPSRVRFSIPRNVF---------LLSAANFIVLAAFFGLLTFLvsFLVNSGVSLKTASLLFSLLSVIGITG 245
Cdd:cd17320 176 etLPEEKRKPLLSSLLRAYKRVLknrrflgyaLALGLSFAGLFAYLAAAPFI--YIEQLGLSPAQFGLLFALNAIALILG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 246 SLVGGGLYDRIGRRSV-------AVVFGLNALLTLILALTASPWVIIPLGITFYSVGAIVTAYTSE--KATGENLGSVMG 316
Cdd:cd17320 254 SLLNGRLVRRFGPRRLlrlglllLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLalEPFPHVAGTASA 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1900934710 317 FVNMVGFFGATVGPYAVGLLIDHfgyekAFLSIPAMYLLAGVLV 360
Cdd:cd17320 334 LLGFLQFLIGALAGALVGLLPNG-----TALPMGLLILVLGLLA 372
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
23-361 |
7.76e-16 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 78.07 E-value: 7.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 23 IPPLIPMIKAELGINNAE-----AGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLA 97
Cdd:cd17391 15 IAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 98 VRALYGLFSGlYYAPATALI-SEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTF 176
Cdd:cd17391 95 LRLLQGVFSG-YVPNATALIaSQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 177 AVRGEVSKPSRVRFSIPRNVFLLSAANFIVLAAFFG-------------LLTFLVSFLVNSGVSLKTAS-LLFSLLSVIG 242
Cdd:cd17391 174 FVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTtfiiqlanqsiepILTLYIRQLMGDASNLAFISgLVFSATGVSS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 243 ITGSLVGGGLYDRIGRRSVAVVFGLNALLTLIL-ALTASPWVIIPLGITF-YSVGAIVTAYTS---EKATGENLGSVMGF 317
Cdd:cd17391 254 LLSAPRLGKLGDRIGHHRILLGALLASALLYIPqAFVQTPWQLGILRFLLgLATGGLLPAINSllaKITPKEVAGRIFGY 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1900934710 318 VNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLVK 361
Cdd:cd17391 334 NQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSF 377
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-360 |
7.89e-16 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 77.97 E-value: 7.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVlsIIGYSLSSA---LIVFAREYWELLAVRAL 101
Cdd:cd17370 20 SILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLV--ILGYGLSALakpLLALAGSWQLVLLLRIL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 102 YGLFSGLYYAPATALISEVYRERK-GSALGVFMVGPPVGSGIAPLIVVPI--AVNLEWRYAFLALSMLSLAIGIALTFAV 178
Cdd:cd17370 98 ERLGKGIRTPPRDALLADATPPSGrGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRTIFLLAAIPALLALLILLFVV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 179 RGEVSKPSRVRFSIPRNVFLLSAA--NFIVLAAFFGLLTFLVSFLV----NSGVSLKTASLLFSLLSVIGITGSLVGGGL 252
Cdd:cd17370 178 KEYPRPPKLRKKSKKTSLKKLPKAfwLYLLAVALFALGNFSFAFLIlraqELGLSAALIPLLYALFNLVYALAAYPAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 253 YDRIGRRSVAVVFGLNALLTLILALTASPWVIIPLGITFYSVG-----AIVTAYTSEKATGENLGSVMGFVNMVGFFGAT 327
Cdd:cd17370 258 SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmgaqeSIERAAVADLVPAELRGTAYGLFNTVVGIGWL 337
|
330 340 350
....*....|....*....|....*....|...
gi 1900934710 328 VGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17370 338 LASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-178 |
8.53e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 77.62 E-value: 8.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 1 MRKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYS 80
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 81 LSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRERK-GSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYA 159
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....*....
gi 1900934710 160 FLALSMLSLAIGIALTFAV 178
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
23-360 |
1.11e-15 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 77.21 E-value: 1.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 23 IPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALY 102
Cdd:cd17477 15 LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 103 GL-FSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIvVPIAVNLEWRyAFLALSMLSLAIGIALTFAVRGE 181
Cdd:cd17477 95 GIgLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGAL-PFLIAAVLLLLALVPLLLTRRAA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 182 VSKPSRVRFSIPRnvfLLSAANFIVLAAFF------GLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDR 255
Cdd:cd17477 173 PEIEEAESISLRR---LLRIAPLALLGAFVagflegAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 256 IGRRSVAVVFGLNALLTLILALTASPWVIIPLGITFYSVGAIVTAYT------SEKATGENLGSVMGFVNMVGFFGATVG 329
Cdd:cd17477 250 FDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTlalalaGDRLPGDELVAANAALLLLYGLGSVIG 329
|
330 340 350
....*....|....*....|....*....|.
gi 1900934710 330 PYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17477 330 PLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
33-360 |
1.92e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 76.88 E-value: 1.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 33 ELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYAP 112
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 113 ATALISEVYR-ERKGSALGVFMVGPPVGSGIAPLIVVPIaVNLEWRYAFLALSMLSLAIGIALTFAVRGEVSKPSRVR-- 189
Cdd:cd17329 109 SEAMIADVTTpENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEkt 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 190 --------FSIPRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRS 260
Cdd:cd17329 188 eilrgykiVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEIlGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 261 VAVVFGLNALLTLILALTASPWVIIPLGITFYSVGAIVT-----AYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGL 335
Cdd:cd17329 268 ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVfpavqTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGL 347
|
330 340
....*....|....*....|....*
gi 1900934710 336 LIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17329 348 LLDLLGPGLPWLILAALGLIAAALL 372
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
25-362 |
3.94e-15 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 75.82 E-value: 3.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL 104
Cdd:cd17333 17 ILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 105 FSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVP-IAVNLEWRYAFLALSMLSLAIGIALTFA------ 177
Cdd:cd17333 97 GAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSlLTSELSWSWAYLIIGLIYLLLAILILLTlfpelp 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 178 ----VRGEVSKPSRVRFSIPRN--VFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGG 250
Cdd:cd17333 177 sarnPQQSVGAFSASASRLLRNpsIILGALALFLYVGAETAFSSWVPSYLVEKkHVSDGLAGYLLSGFWVGITIGRLLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 251 GLYDRIGRRS--VAVVFGLNALLTLILALTASPWVIIPLGITFYSVGAIVT---AYTSEKATGENlGSVMGFVNMVGFFG 325
Cdd:cd17333 257 PISRRIKPHTllVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPtilSLGISNLPYAK-GKGTSVLLAAGSIG 335
|
330 340 350
....*....|....*....|....*....|....*..
gi 1900934710 326 ATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLVKL 362
Cdd:cd17333 336 GAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
8-360 |
1.25e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 74.15 E-value: 1.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 8 LVSLGWVFNYAHRMAIPpLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIV 87
Cdd:cd17504 1 LALAALAVMLVETMLSP-ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 88 FAREYWELLAVRALYGLFSGLYyaP-ATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSM 165
Cdd:cd17504 80 FAPNLPVLIAGRALQGIGGAVF--PlAFALVREEFpPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 166 LSLAIGIALTFAvrgevskpsRVRFSIPRNVFLLSAANFIVLAAFFGLLTFLVSFLVN-----SGVSLKTASLLFSLLSV 240
Cdd:cd17504 158 VAVLLAALVPLI---------DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGAL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 241 IGITGSLVGGGLYDRIGRRSVAVV--FGLNALLTLILALTASPWVI--------IPLGITFYSVGAIVTAYTSEKATGE- 309
Cdd:cd17504 229 VMLIAGPLAGRLIARVGPRRVLLIglVISAVGLLLLALLHSSLWALvvallligIGLGLAFASLPNIVVESVPPDRTGIa 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1900934710 310 --------NLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17504 309 tgmntvlrTIGSAIGPAIAGAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLS 367
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
22-341 |
4.07e-14 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 72.61 E-value: 4.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 22 AIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWeLLAVRAL 101
Cdd:cd17339 17 SVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIAL-LFLGTAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 102 YGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIA--VNLEWRYAFLALSMLSLAIGIALTFAVR 179
Cdd:cd17339 96 AGAGIAVGNVLLPSLIKRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLAqaLGGGWRGALAIWALPALLALLIWLPQLR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 180 GEVSKPSRVRFSIPRNVFLLSAANFIVL------AAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLY 253
Cdd:cd17339 176 RRKRAAAAAAPLTKISVWRSPLAWQVTLfmglqsLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 254 DRIGRRSVAVVFGLNALLTLILALTASPWVIIPLGITFYSVGA------IVTAYTSEKATGENLGSVMGFVNMVGFFGAT 327
Cdd:cd17339 256 TRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGgaafslALTLISLRSSDPAEAAALSGMAQSVGYLLAA 335
|
330
....*....|....
gi 1900934710 328 VGPYAVGLLIDHFG 341
Cdd:cd17339 336 LGPLLFGVLHDLTG 349
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
28-261 |
8.34e-14 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 71.92 E-value: 8.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 28 PMIKAELGINNAEAGLLM---TTLLLPYALIqvpAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL 104
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFsagILGLLPGALL---GGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 105 FSGLYYAPATALISEVYRER-KGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF----------LALSMLSLAIGIA 173
Cdd:PRK11551 116 GLGGALPNLIALTSEAVGPRlRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFyvggvgplllVPLLMRWLPESRA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 174 LTFAVRGEVSKPSRVR--FSIPRNV--FLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVG 249
Cdd:PRK11551 196 FAQAAGAGKQRAPVLRalFGEGRATatLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLI 275
|
250
....*....|..
gi 1900934710 250 GGLYDRIGRRSV 261
Cdd:PRK11551 276 GALMDRLRPRRV 287
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
27-264 |
1.83e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 70.68 E-value: 1.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 27 IPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFS 106
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 107 GLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLalsmLSLAIGIALTFAVrgevskp 185
Cdd:cd17503 99 GVLIPLAQTILLRIYpPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFY----INLPIGILALLLA------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 186 SRVRFSI--PRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVA 262
Cdd:cd17503 168 PLLDLRLfkDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVlGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247
|
..
gi 1900934710 263 VV 264
Cdd:cd17503 248 LA 249
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-259 |
4.67e-13 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 69.53 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL 104
Cdd:cd17323 20 PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 105 FSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFavrgevs 183
Cdd:cd17323 100 FGSSPLAIGAGTIADLFtPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFL------- 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1900934710 184 kpsrvrfsIPRNVFLLSAANFIVLAAFFGLLT-FLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRR 259
Cdd:cd17323 173 --------FLPIVLLLGLYVGLVYAILYLFLTaFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRR 241
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
25-362 |
7.54e-13 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 68.82 E-value: 7.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL 104
Cdd:cd17393 20 TRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 105 FSGLYYAPATALISEVYRERKGSAL----GVFMVGPPVGSGIAPLIVVpIAVNLEWRY-AFLALSMLSLAIGIALTFAVR 179
Cdd:cd17393 100 ANGALDVAMNAQGVAVERAYGRPIMsslhAMWSLGGLAGALLGAAAIG-AGVSPGVHLlAAAVLLLLAALVAIRALLPGT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 180 GEVSKPSRVRFSIPRNVFLLSAANFIVLAAFFGLLT----------FLVSFLvnsGVSLKTASLLFSLLSVIGITGSLVG 249
Cdd:cd17393 179 GEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAegaaadwsalYLRDVL---GASAALAALGYAVFSLAMTVGRLFG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 250 GGLYDRIGRRSVaVVFGLNALLTLILALTASPWVIIP-LGITF----YSVGAIVTAYTSEKATGENLGSVMGFVNMVGFF 324
Cdd:cd17393 256 DRLVDRFGDVAV-LRAGALLAALGLLLALLAPSVWVAlAGFALmglgLSVVVPLAFSAAGALPGLAAGIAVARVATLGYL 334
|
330 340 350
....*....|....*....|....*....|....*...
gi 1900934710 325 GATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLVKL 362
Cdd:cd17393 335 GFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARA 372
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
20-360 |
1.30e-12 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 68.10 E-value: 1.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 20 RMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVR 99
Cdd:cd06180 15 RFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 100 ALYGLFSGLYYAPATALISEVYRE-RKGSALGVFMVGPPVGSGIAPLIVVPI-AVNLEWRYAFLALSMLSLAIGIALTFA 177
Cdd:cd06180 95 FLAGAASAFVFVFGSNLVLHHATAaGRGHLIGLLFAGVGLGIALSGLLVPAGlGGGLSWRAGWLALALLSAVLLLLSFLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 178 VRGEVSKPSRVRFSIP-----RNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGL 252
Cdd:cd06180 175 LRRGPSAPTEASAAESapglnRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGAL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 253 YDRIG-RRSVAVVFGLNALLTLILALTASPWVIIP----LGITFYSVGAIVTAYTSEKAtGENLGSVMGFVNMVGFFGAT 327
Cdd:cd06180 255 SDRWGtRRALAANLLVQAVGVLLPLLSPGPAGLVLsavlFGGTFMAITALVMALARELA-PPAAPRALALMTASFGVGQI 333
|
330 340 350
....*....|....*....|....*....|...
gi 1900934710 328 VGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd06180 334 LGPLLAGWLADATGGFAPALILAAAALVVAALL 366
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
33-342 |
2.06e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.00 E-value: 2.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 33 ELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFG-----RKRLLVLSIIGYSLSSALIVFARE------YWELLAVRAL 101
Cdd:COG2211 40 VLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 102 YGLFSGLYYAPATALISEV---YRERkGSALGVFMVGPPVGSGIAPLIVVPIAVNLE------WRYAFLALSMLSLAIGI 172
Cdd:COG2211 120 LGLAYTLVNIPYSALGAELtpdYEER-TRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 173 ALTFAVRgEVSKPSRVRFSI---------PRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIG 242
Cdd:COG2211 199 LTFFGTK-ERPVPEEEKVSLkeslkallkNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 243 ITGSLVGGGLYDRIGRRSV----AVVFGLNALLTLILALTASPWVIIPLGITFYSVGAI----------VTAYTSEKATG 308
Cdd:COG2211 278 LLGAPLWPRLAKRFGKKKAfiigLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAIlvlpwamladVVDYDEWKTGR 357
|
330 340 350
....*....|....*....|....*....|....
gi 1900934710 309 ENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGY 342
Cdd:COG2211 358 RREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
29-359 |
2.71e-12 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 67.19 E-value: 2.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 29 MIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWEL-LAVRALYGLFSG 107
Cdd:cd17352 28 ELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 108 LYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSL-AIGIALTFAVRGEVSkps 186
Cdd:cd17352 108 LIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLnLCVCGLLLRLLKDPT--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 187 rvrfsiprnVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVF- 265
Cdd:cd17352 185 ---------FVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIf 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 266 --GLNALLTLILALTASPWVII----PLGITFYSVGAIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDH 339
Cdd:cd17352 256 tlLILGLSLLAFPLATTYVGLIvfsvLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDY 335
|
330 340
....*....|....*....|.
gi 1900934710 340 FG-YEKAFLSIPAMYLLAGVL 359
Cdd:cd17352 336 TGdYDAAFYFCGACLLLSGVL 356
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
53-347 |
1.39e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 64.93 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 53 ALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGlfSGLYYAPATALISEVYRERK------- 125
Cdd:cd17472 46 AIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENrtkamal 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 126 -GSALGVFMVgppVGSGIAPLIVVPIAVN-LEWRYAFLALsmLSLAIGIALTFAVRGEVSKPSRVRFSIP-----RNVFL 198
Cdd:cd17472 124 iGASIGIAFA---ISMVLGPLLAAHLGVSgLFLITAILSL--VSLLILLFFVPDPPKIVQISEKEKKKLKkllknKRLLR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 199 LSAANFI---VLAAFFGLLTFLVSFLVNSgvslkTASLLFSLLSVIGIT-GSLVGGGLYDRIGRRS----VAVVFGLNAL 270
Cdd:cd17472 199 LDFSIFIlhfVLMAFFYILPLLLTQLGGG-----KGQLWKVYLPAILIGfILMVPFVIYAEKKGKMkqvfVSSILLIAVG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 271 LTLILALTASPWVIIPLGITFYS----VGAIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAF 346
Cdd:cd17472 274 FLLLLFAATSLWLLIIGLIIFFIgfnlLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVF 353
|
.
gi 1900934710 347 L 347
Cdd:cd17472 354 L 354
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-360 |
6.40e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.02 E-value: 6.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 41 AGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFA-----REYWELLAVRALYGLFSGLYYAPATA 115
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 116 LISE-VYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFlALSMLSLAIGIALTFAVRGEVSKPSRVRFSIP- 193
Cdd:cd06173 116 LLPElVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF-AINALSFLLSALLLLFIRRPPPAAPGESSSLLl 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 194 ----------------RNVFLLSAANFIVLAAFFGLLTFLVSflVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIG 257
Cdd:cd06173 195 rdlreglrylrrspllRLLLLALALFALLGGALTVLLPLLAK--EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 258 RRSVAVVFGLNALLTLILALTASPWVIIPLGITFYSVGAIV-----TAYTSEKATGENLGSVMGFVNMVGFFGATVGPYA 332
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLfnvplNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
330 340
....*....|....*....|....*...
gi 1900934710 333 VGLLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd06173 353 AGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
2-359 |
1.04e-10 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 62.64 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFA----REYWELLAVRALYGLFSGLYYAPATALISEVY--RERkGSALGVFMVGPPVGSGIAPLIVVP---IAV 152
Cdd:cd17345 81 INILIGFVpsatSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFskKER-GTWTSIWNISHNVGGGLVGPLAGLglaIFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 153 NLEWRYAFLALSMLSLAIGIALTFAVRG--------------------EVSKPSRVRFSIP----------RNVFLLSAA 202
Cdd:cd17345 160 DGWWRGAFIFPAIIAIIVAVIVLFLGKDtpeseglppieeykgdypeeADGEEEEQELSAWeifvkyvlknKLLWYIAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 203 NFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRI--GRRSVAVVFGLNALLTLILA--L 277
Cdd:cd17345 240 NVFVYLVRYGILDWAPTYLSEVkGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfkGRRAPTGIIFMILVIVALIVywL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 278 TASPWVI----IPLGITFYSVGAIVTAYTSEKATGENLGSVMGFVNMVGF-FGATVGPYAVGLLIDHFGYEKAFLSIPAM 352
Cdd:cd17345 320 APNVLVDlialIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYlGGSVLATALIGIIVDHFGWNGGFIVLLAS 399
|
....*..
gi 1900934710 353 YLLAGVL 359
Cdd:cd17345 400 CILAIIF 406
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
28-359 |
1.96e-10 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 61.47 E-value: 1.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 28 PMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYW-ELLAVRALYGLFS 106
Cdd:cd17353 27 PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPlLFLGYGVLGGIGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 107 GLYYAPATALISEVYRERKGSALG-VFMvgppvGSGIAPLIVVPIAVNL----EWRYAFLALSMLSLAIGIALTFAVRGE 181
Cdd:cd17353 107 GIGYITPVSTAVKWFPDKRGLATGiVIA-----GFGLGSLIFSPLIAYLintvGVPTTFLILGIIFLIIIVIGAFLIRDP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 182 VSKPSRVRFSIPRNVFLLSAANF-----------------IVLAAFFGLLTFLVSFLV---NSGVSLKTASLLFSLLSVI 241
Cdd:cd17353 182 PKGWVPPGVDPLANNAENSPRDYtpremlrtptfwllwlmFFLNATAGLMLIGQAKPIgqeFAGLDAGIAALAVSILSIF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 242 GITGSLVGGGLYDRIGRR---SVAVVFGLNALLTLILALTASPWVIIPLGITFYSVGAIVT---AYTSEKATGENLGSVM 315
Cdd:cd17353 262 NGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFAlfpALTADFFGTKNAGTNY 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1900934710 316 GFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVL 359
Cdd:cd17353 342 GLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
2-264 |
2.13e-10 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 61.48 E-value: 2.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:PRK12307 16 QKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGVFMV-GPPVGSGIAPLIVVPIAVNLEWRYA- 159
Cdd:PRK12307 96 GTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVsGFGIGNIIAAYFMPSFAEAYGWRAAf 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 160 FLALSMLSLAIGIALT-----------FAVRGEVSKPSRVRFSIP------RNVFLLSAANFIVLAAFFG----LLTFLV 218
Cdd:PRK12307 176 FVGLLPVLLVIYIRARapeskeweeakLSGKGKHSQSAWSVFSLSmkglfnRAQFPLTLCVFIVLFSIFGanwpIFGLLP 255
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1900934710 219 SFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVV 264
Cdd:PRK12307 256 TYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSI 301
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
26-329 |
2.14e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 61.04 E-value: 2.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 26 LIPMIKAELGiNNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLF 105
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 106 SGLYYAPATALISEVYRERK-GSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLalsmLSLAIGIALTFAVrgevsk 184
Cdd:cd17502 97 GGGLMSLAFIIIADLVPPRErGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY----INLPIGGLALALL------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 185 psrvrfsipRNVFLLSAANFIVLAAFFGLLTFLVSFLVN-SGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAV 263
Cdd:cd17502 167 ---------RTILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLI 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1900934710 264 VFGLNALLTLILALTASPWVIIPLGITFYS------VGAIVTAYT---SEKATGENLGSVMGFVNMVGFFGATVG 329
Cdd:cd17502 238 VIGTILMSVGAGLLTTLTLDTSKWLLIGYLillglgLGIGFQQPLvavQNAVPPADVGVATATNTFFRSLGGTLG 312
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
25-362 |
6.43e-10 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 59.93 E-value: 6.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVF-AREYWELLAVRALYG 103
Cdd:cd17490 17 PFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMIlFPSPWGLLIARFLSG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 104 lFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLaLSMLSLAIGIALTFAVRGEV 182
Cdd:cd17490 97 -IAAATWVSFTVLYASYFpPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFL-LAALAGVLGFILSLFIKEER 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 183 SKPSRVRFSIP--------RNVFLLSAANFIVLAAFFG-LLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGL- 252
Cdd:cd17490 175 REKKPVLTELKellsvlkdKKLLFFSLLAILQQMITFStTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLf 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 253 YDRIGRRS-VAVVFGLNALLTLILALTASPWVIIPL----GITFYSVGAIVTAYTSEKATGENLGSVMGFVNMVGFFGAT 327
Cdd:cd17490 255 YKKLGERNtIIIGFLLLGAYCFLIPFAPNLTLLYLLqalnGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMF 334
|
330 340 350
....*....|....*....|....*....|....*
gi 1900934710 328 VGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVLVKL 362
Cdd:cd17490 335 LGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
2-349 |
1.39e-09 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 59.34 E-value: 1.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:PRK11663 21 RRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:PRK11663 101 INILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYsRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGM 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 LALSMLSLAIGIALTFAVRgevSKPSRV--------------------------RFSIPRNVFLlsaANFIVLAAFFGLL 214
Cdd:PRK11663 181 MIAGIIAIVVGLFLCWRLR---DKPQAMglpsvgewrhdalelaqqqegaglsrKEILTKYVLL---NPYIWLLSFSYVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 215 TFLVSFLVNS----------GVSLKTASLLFSLLSVIGITGSLVGGGLYDRI---GRRSVAVVFGLNALLTLILALTASP 281
Cdd:PRK11663 255 VYVVRAAINDwgnlymsetlGVDLVTANSAVSMFELGGFIGALVAGWGSDKLfngNRGPMNLIFAAGILLSVGSLWLMPF 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1900934710 282 WVIIPLGITFYSVGAIVTA-------YTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSI 349
Cdd:PRK11663 335 ASYVMQAACFFTIGFFVFGpqmligmAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTGFFVVI 409
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
46-176 |
1.59e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 55.73 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 46 TTLLLPYALIQV----PAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY 121
Cdd:TIGR00880 1 GLLLAGYALGQLiyspLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1900934710 122 -RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTF 176
Cdd:TIGR00880 81 pPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAF 136
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
199-360 |
1.71e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.74 E-value: 1.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 199 LSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVV-FGLNALLTLILAL 277
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 278 TASPWVIIPL----GITFYSVGAIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMY 353
Cdd:cd17325 81 ATSYWQLLLArflqGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
....*..
gi 1900934710 354 LLAGVLV 360
Cdd:cd17325 161 LLALVLA 167
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
6-362 |
2.56e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.03 E-value: 2.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 6 LLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSS-A 84
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLlA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 85 LIVFAREYWELLAVRALYGlFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLE-------W 156
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLG-FAGANFASGQPWASFWFpKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVfdggfvgW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 157 RYAFLALSMLSLAIGIA-------LTFAVRGEVSKPSRVRFSIPR-NVFLLSAANFIVLAAFFGLLTFLVSFLV-NSGVS 227
Cdd:cd17341 160 RNAFFVPGILLAIAAVLvllfgddLPTGKASALEFLKVQLAVLKNyRTWILSLLYGVTFGSFVGFSNVLPTYFKtRFGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 228 LKTASLLFSLLSVIGITGSLVGGGLYDRIG-RRSVAVVF-GLNALLTLILALTASPWVIIPLGITFYSVGAIVTAYTS-- 303
Cdd:cd17341 240 LVTAGILAALFPLAGALARPAGGWLSDRFGgRRRLWWLFiVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNgs 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1900934710 304 -----EKATGENLGSVMGFVNMVGFFGATVGPYAVGLLID-HFGYEKAFLSIPAMYLLAGVLVKL 362
Cdd:cd17341 320 vfrmvPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALmTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
59-360 |
7.98e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 56.43 E-value: 7.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 59 AGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEV----YRERKGSALGVFMV 134
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIvgpkYRSFVGILFGLFWA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 135 GppvgsGIAPLIVVPIAVNlEWRYAFLALSMLSLaIGIALTfavrgevskpsrvrFSIPRNVFLLSAANFIVLAAFFGLL 214
Cdd:cd17317 125 L-----GYMLLALLAYLIR-DWRWLQLAISLPGL-LFLLLL--------------WWLPRRTIIVGLIWFVTSLVYYGLS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 215 TFLVSFLVNSGVSlktasllFSLLSVIGITGSLVGGGLYDRIGRR---SVAVVFGLNALLTLILALTASPWviipLGITF 291
Cdd:cd17317 184 LNSSNLGGNLYLN-------FFLSGLVEIPAYFLALLLLDRLGRRwtlSGSLLLAGLACLVTALLPDDENT----LALTL 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1900934710 292 YSVG--------AIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVglLIDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17317 253 ALVGkfaisaafSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIV--LLGKIGPLLPLIIFGVLALLGGLLT 327
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-356 |
1.16e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 56.05 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 21 MAIPPLIPMIKAELGINNA--EAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAV 98
Cdd:cd17330 14 IVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 99 RALYGLFSGlYYAPATALISEVYRERK-GSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLaigIALTFA 177
Cdd:cd17330 94 RFLDGLTGG-NVSVAQAYIADITDEEErAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALAL---LNLVLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 178 VRgevskpsrvrfsIPRNVFLLSAANFIVLAAFFGLLTFLVSFLV-NSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRI 256
Cdd:cd17330 170 LF------------FLPPLRRLLLVYFLIALAFAGLESVFSLFLKdRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 257 GRRSVAVVFGLNALLTLILALTASPWVII-PLGITFYSVGAIVT-----AYTSEKATGENLGSVMGFVNMVGFFGATVGP 330
Cdd:cd17330 238 LGERKLLRLGLLLAIIGLLLLPFASSVPLlVLAAAILAFGTGIVfpalsALLSKSVPSKEQGKAQGIIQSLQSLARIIGP 317
|
330 340
....*....|....*....|....*.
gi 1900934710 331 YAVGLLIDHFGYEKAFLSIPAMYLLA 356
Cdd:cd17330 318 LLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
3-174 |
1.36e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 3 KRLLLLVSLGWVFNYAHrmaipPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLS 82
Cdd:cd17370 203 WLYLLAVALFALGNFSF-----AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 83 SALIVFAREYWELLAVRALYGLFSGLYYAPATALISE-VYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFL 161
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADlVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
170
....*....|...
gi 1900934710 162 ALSMLSLAIGIAL 174
Cdd:cd17370 358 FSAVLALIALLLL 370
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
21-265 |
1.73e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 55.39 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 21 MAIPPLIP-MIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFARE-YWELLAV 98
Cdd:TIGR00886 18 FAFSPLAVfLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQsYSVLLLI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 99 RALYGlFSGLYYAPATALISEVYRER-KGSALGVFMVGPPVGSGIAPLIVVPIAVNLE----------WRYAFLALSMLS 167
Cdd:TIGR00886 98 RLFIG-IAGGSFASCMPWISFFFPKKiQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIfgggqpahlaWGWAFVIVPAGI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 168 LAIGIALTFAV--RGEVSKPSRVRFSIP--------RNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFS 236
Cdd:TIGR00886 177 LLLPALLIFFVgaDTPPGKPATGKLSFKealkvfgnRHTWILALLYSVTFGSFLGVSSIFAMLFKDQfGLSKVQAGAYAS 256
|
250 260
....*....|....*....|....*....
gi 1900934710 237 LLSVIGITGSLVGGGLYDRIGRRSVAVVF 265
Cdd:TIGR00886 257 LGGFLGSLARPAGGAISDRLGGARKLLMN 285
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
5-265 |
3.53e-08 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 54.53 E-value: 3.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 5 LLLLVSLGWVFNYAHRMAIPPlIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSA 84
Cdd:PRK11652 10 LFMLVLLVAVGQMAQTIYVPA-IADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 85 LIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYR----ERKGSALGVFMVGPPVgsgIAPLIVVPIAVNLEWRYAF 160
Cdd:PRK11652 89 VALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEgtqlRHANSLLNMGILVSPL---LAPLIGGLLTTLFGWRACY 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 LALSMLSLAIGIALTFAVRGEVSKPSRVRFSIPRNVFLLSAANF-----IVLAAFFGLLTFLVSFLVNSGVSLKTASLLF 235
Cdd:PRK11652 166 LFLLLLGAGVTFSMARWMPETRPADARRTRVLASYRTLLSNRRFncyllMLIGTLAGIAVFEACSGVLMGAVLGLSSMTV 245
|
250 260 270
....*....|....*....|....*....|
gi 1900934710 236 SLLSVIGITGSLVGGGLYDRIGRRSVAVVF 265
Cdd:PRK11652 246 SILFILPIPAAFFGAWFAGRPNKRFSTLMW 275
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-134 |
3.76e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.59 E-value: 3.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 1 MRKRLLLLVSLGWVFNYAHRMAIPPLIP-MIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGY 79
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPlYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1900934710 80 SLSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMV 134
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNS 339
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
3-145 |
3.92e-08 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 54.54 E-value: 3.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 3 KRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGIN-----NAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSII 77
Cdd:PRK09874 13 KRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTghsalNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSAL 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1900934710 78 GYSLSSALIVFAREYWELLAVRALYGLFSGlYYAPATALI-SEVYRERKGSALGVFMVGPPVGSGIAPL 145
Cdd:PRK09874 93 GMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIaTQVPRNKSGWALGTLSTGGVSGALLGPL 160
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-179 |
8.55e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.34 E-value: 8.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 26 LIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGR--KRLLVLSIIGYSLSSALIVFAREYWELLAVRALYG 103
Cdd:COG2271 203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1900934710 104 LFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFAVR 179
Cdd:COG2271 283 FGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
96-347 |
1.40e-07 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 52.89 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 96 LAVRALYGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSmlslaiGIALT 175
Cdd:cd17424 96 LTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILG------GFVLN 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 176 FAVRGEVskpsrVRFSIPRNvFLLSAANFIVLAAFFGLL-TFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYD 254
Cdd:cd17424 170 LCVCGAL-----MRFLLMPD-FLVLAVSVLFLAYGCSPPfVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTD 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 255 R---IGRRSVAVVF--GLNALLTLILALTASPWVIIPLGITF-YSVGAIVT---AYTSEKATGENLGSVMGFVNMVGFFG 325
Cdd:cd17424 244 RrclKKYRYFCYLFavGMDGLCCLFLPILKTFPLLVPFSFTFgYFDGAYVAlipVVTSDVVGTSSLSSALGVVYFLHAVP 323
|
250 260
....*....|....*....|...
gi 1900934710 326 ATVGPYAVGLLIDHFG-YEKAFL 347
Cdd:cd17424 324 YLVSPPIAGWLVDTTGtYTAAFL 346
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
27-162 |
1.48e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 53.16 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 27 IPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL-F 105
Cdd:PRK03893 43 LTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMgM 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1900934710 106 SGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLA 162
Cdd:PRK03893 123 AGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFI 179
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
23-176 |
2.00e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.19 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 23 IPPLIPMIKAELGI--NNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRA 100
Cdd:cd17315 16 INGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1900934710 101 LYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLE--WRYAFLALSMLSLAIGIALTF 176
Cdd:cd17315 96 LLGLGVGLASVLVPLYISEIApAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLLMFF 174
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
42-346 |
2.32e-07 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 52.32 E-value: 2.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 42 GLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGyslsSALIVFA----------REYWELLAVRALYGLFSGLYYA 111
Cdd:cd17342 66 GVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCS----SAITVFLfgvltewlhfYNKYLYCILWVLNGLLQSTGWP 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 112 PATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIaVNLEWRYAFLALSMLSLAIGIALTFAVrgevskpsrvrF 190
Cdd:cd17342 142 CVVAIMGNWFgKSSRGFVLGLWSACASVGNIIGALLASSV-LDYGYEYAFLVTSSLLFAGAIVVFFGL-----------L 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 191 SIPRNVFLLSAANF---IVLAAFFGLLTFLVSflVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGL 267
Cdd:cd17342 210 SSPPGVIPYSLAYAclkLVNYSFFFWLPFYLS--NNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVML 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 268 NALLTLILALTASP----WVIIPLGITFYSVGA----IVTAYTSE-------KATGENLGSVMGFVNMVGFFGATVGPYA 332
Cdd:cd17342 288 LLAIPSLFVYSHSPsdkvLNAFVMTITGFFIGGpanlISSAISADlgrqpqlRGSSEALATVTGIIDGTGSIGAAIGQVL 367
|
330
....*....|....
gi 1900934710 333 VGLLIDHFGYEKAF 346
Cdd:cd17342 368 VPLIQNRLGWMWVF 381
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
37-359 |
3.33e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 51.47 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 37 NNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALI-VFAR-EYWELLAVRALYGLFSGLYYAPAT 114
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTpLAARgGYGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 115 ALISE-VYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFlalsMLSLAIGIALTFAVrgevskpsrVRFSIP 193
Cdd:cd17318 134 ALWAKwAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIF----YIFGGLGLLWCLLW---------FFLVLP 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 194 rnVFLLSAANFIVLAAFFGLLTFLVSFLVN-SGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRR------------- 259
Cdd:cd17318 201 --VWAIVVAHFGHNWGFYTLLTELPTYMSDvLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRgilstttvrklft 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 260 SVAVVFGLNALLTLILALTASPWVIIPLGItfySVGAIVTAYTSEKATGENL-----GSVMGFVNMVGFFGATVGPYAVG 334
Cdd:cd17318 279 SIGFLGPGVFLIALGYLGSNATLAVVFLTL---SVGLSGACYSGFLVNHLDLapnyaGTLMGITNTAATIAGIISPLIVG 355
|
330 340
....*....|....*....|....*....
gi 1900934710 335 LLIDH----FGYEKAFLSIPAMYLLAGVL 359
Cdd:cd17318 356 AIVKNdqtiGQWRIVFFISAAIYILGAIF 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
194-360 |
4.14e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 4.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 194 RNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVV-FGLNALLT 272
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLgLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 273 LILALTASPWVIIPL----GITFYSVGAIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLS 348
Cdd:COG2814 90 LLCALAPSLWLLLAArflqGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170
....*....|..
gi 1900934710 349 IPAMYLLAGVLV 360
Cdd:COG2814 170 NAVLALLALLLL 181
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
60-261 |
5.77e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 50.99 E-value: 5.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 60 GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWE--------LLAVRALYGLFSGLYYAPATALISE-VYRERKGSALG 130
Cdd:cd17369 65 GHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLALGGEWGGAVLMAVEhAPPKRRGFYGS 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 131 VFMVGPPVGSGIAPLIVVPIAVNLE--------WRYAFLaLSMLSLAIGIALTFAV-----------RGEVSK--PSRVR 189
Cdd:cd17369 145 FPQLGAPVGLLLATGVFLLLSALLSdeaflswgWRIPFL-LSAVLVAVGLYIRLRLeetpvfrrakeAGQVVRapLVEVL 223
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1900934710 190 FSIPRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSV 261
Cdd:cd17369 224 RRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTlGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPV 296
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
26-360 |
7.93e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 50.70 E-value: 7.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 26 LIPMIKAELGINNAEAGLLMTtlLLPYA--LIQVPAGYIGDR----FGRKR--LLVLSIIGySLSSALIVFAREYWELLA 97
Cdd:cd17313 21 YVPPILQTLGLSHALIGFVWT--LGPILglFVQPLVGSLSDRcnsrIGRRRpfILVGAPLA-ALGLILIPNAADIGLALG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 98 VR-------------ALYGLFSGLYYAPATALISEVYRERKGS-ALGVFMVGPPVGSGIAPLI--------VVPIAVNLE 155
Cdd:cd17313 98 DGprtwalvlfvlgiVLLDFAMNVCQGPVRALLPDLVPPEQRSkANGIINFMGGLGGVLGYLLgailwdhnWFGFALGGN 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 156 WRYAFLALSMLSLAIGIALTFAVR---------------GEVSKPSRVRFSI---PRNVFLLSAANFIVLAAFFGLLTFL 217
Cdd:cd17313 178 LKVPFYIGAIILLVCVLVTLFFVKepplspeagehsenpSLGEVLKSLLKLLkimPRSLLRLLLVIFFWWIAFFPFELFF 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 218 VSFLVNS------------GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSV--------AVVFGLNALLTLILAL 277
Cdd:cd17313 258 TDYMGEEvyhgtsaasshyGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVyliglvlfAVGMALMALVHNVTVA 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 278 TASPWVI-IPLGITFYSVGAIVTAYTSEKatGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLA 356
Cdd:cd17313 338 LVLFALGgIGWATININPYPLVSDYHSES--GRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLS 415
|
....
gi 1900934710 357 GVLV 360
Cdd:cd17313 416 LVGA 419
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
28-266 |
9.76e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.95 E-value: 9.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 28 PMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSG 107
Cdd:cd17476 22 PIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 108 LYYAPATALISEVYRE--RKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFAVRGEVSkp 185
Cdd:cd17476 102 FLLPNAMALLGRTYPPgpRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWTSPSFI-- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 186 srvrfsiprnvfllsaanFIVLAAFFGLLTFLVS-------FLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIgR 258
Cdd:cd17476 180 ------------------AVLLAVFLGWASFGIWvfyatqyFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARL-P 240
|
....*...
gi 1900934710 259 RSVAVVFG 266
Cdd:cd17476 241 PSYIMAIS 248
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
53-360 |
1.25e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 49.72 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 53 ALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFA-REYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGV 131
Cdd:cd17314 52 LLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVfNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 132 fmvgPPVGSGIAPLIVVPIAVNLEWRYAF-LALSMLSLAIGIALTFAVRGEVSKPSRVRFSIPRN-------VFLLSAAN 203
Cdd:cd17314 132 ----PTTGYSLGLVLGSPLLRILWVFYGLaLVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQkkktqtmGEIFRDKV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 204 FIVLA-AFFGLLTFLVSFLVNSG-----VSLKTASLLFSLLSVIGIT---GSLVGGGLYDRIGRR----SVAVVFGLNAL 270
Cdd:cd17314 208 FWILFiAIFLVLIGGFLFIANMAslvrsLQLDAPSFVTKLMSIYGLFnafGRLLWGIVADFFGGRlstlSILLTILGLGL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 271 LTLILALTASPWVIIPLG-ITFYSVGAIVTAY---TSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLID-HFGYEKA 345
Cdd:cd17314 288 CAFLFLLKMTPVGLVLTGsLLGFSYGGLFTVYpatVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDrTPSYISA 367
|
330
....*....|....*
gi 1900934710 346 FLSIPAMYLLAGVLV 360
Cdd:cd17314 368 VYIYAVIVFLASAIL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
199-362 |
1.43e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 199 LSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGLNALLTLILAL 277
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 278 TASPWVIIPLGITFYSVG-----AIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAM 352
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGagalfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|
gi 1900934710 353 YLLAGVLVKL 362
Cdd:pfam07690 161 SLLAAVLLLL 170
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
22-341 |
2.07e-06 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 48.95 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 22 AIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRAL 101
Cdd:cd17410 17 SVGPLLNEIRAATGLSFQVASLLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 102 YGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFAVRGE 181
Cdd:cd17410 97 GGLGIAIIQALVPGLIKRRFPARVPLAMGLYSASLMAGGGLAASLSPRLAQHSAGWQLGLGIWAVPALVALVLWWRQPPR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 182 VSKPSRVRfSIPRNVFLLSAAnfIVLAAFFGL--------LTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGLY 253
Cdd:cd17410 177 EVAPSDTA-GPGVRFFRNRRA--WLLALYFGLinagytsmIAWLPAYYLELGWSAQDSGSLLGFMTIFQVLGALVMPALA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 254 DRIGRRSVAVVFGLNALLTLILALTASP------WV-IIPLGI-TFYSVGAIVTAYTSEKAtgENLGSVMGFVNMVGFFG 325
Cdd:cd17410 254 RRSADRRPLLMGALAAQLAGFLGLILMPqslpllWVaLIGLGLgACFSLGLILALDHLRKP--RAAGQLAAFVQGIGFII 331
|
330
....*....|....*.
gi 1900934710 326 ATVGPYAVGLLIDHFG 341
Cdd:cd17410 332 TGISPWIAGWLRDSTG 347
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
60-355 |
2.66e-06 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 48.81 E-value: 2.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 60 GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGlYYAPATALISEVY-RERKGSALGVFMVGPPV 138
Cdd:cd17389 85 GAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKG-NVSLSTAIVADVTsPKKRSKGMALIGVAFSL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 139 GSGIAPLIVVPIAVNLEwRYAFLALSMLSLaigIALTFAVRGEVSKPSRVRFSIPRNVFLLSAANFIVLAAFFGlLTFLV 218
Cdd:cd17389 164 GFIIGPMIGAYFASFTR-SLGEVFFSMPAL---FALVLALADLLFIFFFLPETLPSNLRRLGLVYFLYLFLFSG-LEFTL 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 219 SFLVN---SGVSLKTASLLFsllsVIGITGSLVGGGLYDRI--GRRSVAVVFGLNALLTLILALTASPWVII-PLGITFY 292
Cdd:cd17389 239 TFLTHqrfQYTSMQQGKMFF----FIGIIMALVQGGYVRRIkpGKEKKAVLQGLILLIPAFLLIGWASSVTVlYAGLFLY 314
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1900934710 293 SVGAIV-----TAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLSIPAMYLL 355
Cdd:cd17389 315 SFAAATvvpclTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGALLFLL 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
4-147 |
3.43e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 3.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 4 RLLLLVSLGWVFNYAHRMAIppLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSS 83
Cdd:COG2211 231 LLLLLAYLLFFLALALVAAL--LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1900934710 84 ALIVFARE--YWELLAVRALYGLFSGLYYAPATALISEV--------YRERKGSALGVFMVGPPVGSGIAPLIV 147
Cdd:COG2211 309 LLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewktGRRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
27-260 |
8.33e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.18 E-value: 8.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 27 IPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFS 106
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 107 GLYYAPATALISEVY-RERKGSALGVF--------MVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFA 177
Cdd:cd17359 104 GGASALVPMYIAEVApAEIRGRLVSLNqlmivfgqLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 178 vrgevskPSRVRFSIPRNVFLLSAAnfIVLAAFFGLLTFLVSF------LVNSGVSLKTASLLFSLLSVIGITGSLVGGG 251
Cdd:cd17359 184 -------PESPRWLVSKGKPILIIG--IGLAIFQQFVGINVIFyygpeiFQNAGFSENAALLQTIGIGVVNVIFTIIAIL 254
|
....*....
gi 1900934710 252 LYDRIGRRS 260
Cdd:cd17359 255 LVDKVGRKP 263
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
60-303 |
9.11e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 47.29 E-value: 9.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 60 GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWE--------LLAVRALYGLFSGLYYAPATALISEVYRERK----GS 127
Cdd:cd17367 61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRrgfySS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 128 ALGVFMVGppvGSGIAPLIVVPIAVNLE--------WRYAFLALSMLSLAIGI-------ALTFAVRGEVSKPSRVRFSI 192
Cdd:cd17367 141 FQYVTLIG---GQLLALGVLLVLQHTLGedqmaawgWRIPFLLGGVLAVVVLWlrrgleeTESFEAIAESNEASAGTLRE 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 193 PRN-------VFLLSAANFIvlaAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVV 264
Cdd:cd17367 218 LRRhprelllVVGLTAGGTL---AFYTWTTYLQKFLVNTaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLF 294
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1900934710 265 FGLNALLTLILALTASPWVIIPLGITFY-SVGA-IVTAYTS 303
Cdd:cd17367 295 FGIGGTLATVPLLSALDHTDSPYTAFALvLVGLvFLSGYTS 335
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
9-130 |
1.04e-05 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 47.18 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 9 VSLGWVFNYAHRmAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVF 88
Cdd:cd17433 12 LSFGFVLGYSSP-AIPSLQRIADPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITA 90
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1900934710 89 AREYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALG 130
Cdd:cd17433 91 AQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLG 132
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
59-176 |
1.27e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.88 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 59 AGYIGDRFGRKRLLVLSIIGYSLSSALIVFA---REYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGVF--- 132
Cdd:pfam00083 66 AGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLyql 145
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1900934710 133 --MVGPPVGSGIApLIVVPIAVNLEWRYAFLALSMLSLAIGIALTF 176
Cdd:pfam00083 146 aiTFGILLAYIFG-LGLNKTSNSDGWRIPLGLQLVPALLLIIGLLF 190
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
199-360 |
2.41e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 45.62 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 199 LSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGLNALLTLILAL 277
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEElGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 278 TA--SPWVIIPLGITFYSVGAIVTAY-------TSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFGYEKAFLS 348
Cdd:cd17471 81 AFlrNYWVLLLVGVVLLSLGAAAFPQlfalareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170
....*....|..
gi 1900934710 349 IPAMYLLAGVLV 360
Cdd:cd17471 161 AALLYLVVALLV 172
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
25-261 |
2.95e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 45.45 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL 104
Cdd:TIGR00710 26 PAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 105 FSGLYYAPATALISEVYRERKGSAL-GVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFAVRGEVS 183
Cdd:TIGR00710 106 GASAGSVISQALVRDIYPGEELSRIySILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 184 KPSRVRFSIPRNVFLL-------------SAANFIVLAAFFGLLTFLVSFLVnsGVSLKTASLLFSLLSVIGITGSLVGG 250
Cdd:TIGR00710 186 YEARIQISTYFETFLLllkskmfwgyaliYGASFGGFFAFFSGAPFVYIDIM--GVSPSVFGLLFALNIIAMIFGGFLNG 263
|
250
....*....|.
gi 1900934710 251 GLYDRIGRRSV 261
Cdd:TIGR00710 264 RFIKKWGAKSL 274
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
33-261 |
2.96e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 45.62 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 33 ELGINNAEAGLLMTTLLLPYALIQVPAGYIGDR-FGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYA 111
Cdd:cd17471 26 ELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 112 PATALISEVYRERKGSALGVFM------------VGPPVGSGIAPLivvpiavnLEWRYAFLALSMLSLAIGIALTF--- 176
Cdd:cd17471 106 QLFALAREYADRSSGRDATLFNsvlraafslawvIGPPLAFLLLDV--------LGFTGLFLLAALLYLVVALLVLFllp 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 177 ----AVRGEVSKPSRVRFSIPRNVFLLSAANFIVLAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGG 251
Cdd:cd17471 178 svkpPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNElGGSESWVGLLFGLAAALEIPIMLLAGL 257
|
250
....*....|
gi 1900934710 252 LYDRIGRRSV 261
Cdd:cd17471 258 LAKRFGKRRL 267
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
30-184 |
3.80e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 45.32 E-value: 3.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 30 IKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLY 109
Cdd:cd17327 32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGV 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 110 YaPATALISEVY--RERKGSALGVFMVGPPVGSGIAPLIV-----VPIAVNLE-WRYAFLALSMLSLAIGIALTFAVRGE 181
Cdd:cd17327 112 F-PGFILYLGMWykREEQAKRIAFFYAAAGLGSIFGGLLAygvfkILGVGGLAgWRWLFIIEGLITIIIGLVIFFWLPDN 190
|
...
gi 1900934710 182 VSK 184
Cdd:cd17327 191 PSK 193
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
60-173 |
4.52e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.01 E-value: 4.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 60 GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEV----YRERKGSALGVF-MV 134
Cdd:TIGR00898 148 GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFlpkkQRAIVGTLIQVFfSL 227
|
90 100 110
....*....|....*....|....*....|....*....
gi 1900934710 135 GPPVGSGIAPLIvvpiavnLEWRYAFLALSMLSLAIGIA 173
Cdd:TIGR00898 228 GLVLLPLVAYFI-------PDWRWLQLAVSLPTFLFFLL 259
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
34-238 |
5.29e-05 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 44.81 E-value: 5.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 34 LGINNAEAGLLMTTLL-LPYALIqVPAGYIGDRF-GRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYA 111
Cdd:COG3104 50 LGLSEADAAAIYGAYTaLVYLTP-LLGGWLADRLlGQRRAILLGGILMALGHFLLALPGGVTLFYLGLALIAVGNGLFKP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 112 PATALISEVYRE---RKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLAlSMLSLAIGIALTFAVRGE-VSKPSR 187
Cdd:COG3104 129 NISSLVGQLYDPgdpRRDAGFTIFYMGINIGAFLAPLLCGYLGEKYGWHYGFGA-AAIGMLIGLIIFLLGRKYlGDIGLE 207
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1900934710 188 VRFSIPRNVFLLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLL 238
Cdd:COG3104 208 PDNPLSKKERLIAVALGALLLVLVLAGLLSNANIANYLLYVIAIIAYFIFI 258
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
22-341 |
6.87e-05 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 44.42 E-value: 6.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 22 AIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRAL 101
Cdd:PRK09705 27 SVGPLLPQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 102 YGLFSGLYYAPATALISEVYRERKGSALGVF----MVGPPVGSGIAPLIVvpiAVNLEWRYAFLALSMLSLAIGIALTFA 177
Cdd:PRK09705 107 GGVGIGIIQAVMPSVIKRRFQQRTPLVMGLWsaalMGGGGLGAAITPWLV---QHSETWYQTLAWWALPAVVALFAWWWQ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 178 VRGEVSKPSRVRFSIPRNVF-----LLSAANFIVLAAFFGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVGGGL 252
Cdd:PRK09705 184 SAREVASSHKTTTTPVRVVFtprawTLGVYFGLINGGYASLIAWLPAFYIEIGASAQYSGSLLALMTLGQAAGALLMPAM 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 253 YDRIGRRS---VAVVFGLNALLTLILALTASPWVI-----IPLGITFYSVGAIVTAYTSEKATGenlGSVMGFVNMVGFF 324
Cdd:PRK09705 264 ARHQDRRKllmLALVLQLVGFCGFIWLPLQLPVLWamvcgLGLGGAFPLCLLLALDHSVQPAIA---GKLVAFMQGIGFI 340
|
330
....*....|....*..
gi 1900934710 325 GATVGPYAVGLLIDHFG 341
Cdd:PRK09705 341 IAGLAPWFSGVLRSISG 357
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
60-146 |
7.64e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 44.26 E-value: 7.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 60 GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGV-----FMV 134
Cdd:cd17379 54 GYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIvyqmfFTL 133
|
90
....*....|..
gi 1900934710 135 GPPVGSGIAPLI 146
Cdd:cd17379 134 GLLILPGIAYFI 145
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
23-163 |
1.02e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 23 IPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVP----AGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAV 98
Cdd:cd17388 18 IMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIfapiLGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 99 RALYGlFSGLYYAPATALISEVYRERK--------GSALGVFMVGPPVGSGI-------APLIVVPIAVNLEWRYAFLAL 163
Cdd:cd17388 98 RIIAG-ITGATGAVAAAYIADVTPPEQrarnfgllGAAFGLGFIAGPALGGLlgeisprAPFLVAAGLNGLNFLLGLFVL 176
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
6-265 |
1.74e-04 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 43.29 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 6 LLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDR-FGRKRLLVLSIIGYSLSSA 84
Cdd:TIGR00924 15 LFFVELWERFSYYGMQGILAVYLVQQAGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRvWGTKKTMVLGGIVLMLGHF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 85 LIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRE----RKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:TIGR00924 95 MLAMSIYPDLIFYGLGTIAVGSGLFKANPSSMVGKLYERgdmpRRDGGFTLFYMSINIGSFISPLLAGVIAENYGYHVGF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 161 lALSMLSLAIGIALTFAVRGEVSKPSRVRFSIPRNVFLLSAANFIVLAAffgLLTFLVSFLVNSGVSLKTASLLFSLLSV 240
Cdd:TIGR00924 175 -NLAAVGMVIGLLTFFAGRHMLRDIGSVPDPLSGQGKTYGKLLLALLAA---LALVFFCAWLMHHVVIANILLMTVTLAV 250
|
250 260
....*....|....*....|....*
gi 1900934710 241 IGITGSLVGGGLYDRIGRRSVAVVF 265
Cdd:TIGR00924 251 IIFFFRLAFKPRLDAVARNKMYAYI 275
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
25-192 |
1.77e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 42.98 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGL 104
Cdd:PRK11102 12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 105 FSglyyAPATALISEVYRE--------RKGS-ALGVFMVGPPVgsgiAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALT 175
Cdd:PRK11102 92 AA----AAASVVINALMRDmfpkeefsRMMSfVTLVMTIAPLL----APIIGGWLLVWFSWHAIFWVLALAAILAAALVF 163
|
170
....*....|....*..
gi 1900934710 176 FAVRGEVSKPSRVRFSI 192
Cdd:PRK11102 164 FFIPETLPKERRQPFHL 180
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
24-176 |
1.97e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 42.95 E-value: 1.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 24 PPLIPMIKAE----LGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVR 99
Cdd:cd17358 22 SPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGR 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1900934710 100 ALYGLFSGLYYAPATALISEVYRERKGSALGVFMVGpPVGSGIapLIVVPIAVNLEWRYAFLALSMLSLAIGIALTF 176
Cdd:cd17358 102 FLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQL-LVNIGI--LLGYVLGSFLPWRTLALIGAIPPVVFLILLFF 175
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
11-333 |
2.32e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 42.71 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 11 LGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAR 90
Cdd:cd17343 10 VGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 91 EYWELLAVRALYGLFSGLYYAPATALISEVYR-ERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLA 169
Cdd:cd17343 90 SVWVFSILWFLNGLAQGLGWPPCAKILRKWFSpSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 170 IGIALTFAVRGE------------VSKPSRVRFSIPRN----------VFLLSAANFIVLAAFFGLLTFLVSFLV-NSGV 226
Cdd:cd17343 170 MSVVCLLFIKNEpsdvglnnieeeESKGKKKKSPRGEStlkelllspfLWLLSLGYLVVFGVKTAVTDWGQLFLIqDKGQ 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 227 SLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGLNALLTLIlaltaspWVIIPLGITFYSVGAIVTAYTSEKa 306
Cdd:cd17343 250 SALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLAL-------VFMAGLTVSLHLFRVHITSDSSEL- 321
|
330 340
....*....|....*....|....*....
gi 1900934710 307 tgenlgsvmgFVNMVGF-FGATV-GPYAV 333
Cdd:cd17343 322 ----------FILLLGFlIGFSLyGPIAI 340
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
25-359 |
2.38e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 42.57 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKR-LLVLSIIGYSLS-SALIVFAREYWELLAVRALY 102
Cdd:cd17335 18 PFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKaLLLLSLLAAVLFfLSLFFVAQIFWLLLLLVILG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 103 GLFSglyyAPATALIS-------EVYRERKGS---------ALGVFMVGPPVG--SGIAPLIVVPiavnlewrYAFLALS 164
Cdd:cd17335 98 AFFS----APVVPLVDsitlqylGEERERYGKqrlwgsigfGIAALLVGILIDrsSTYKNYTIAF--------YVFAVLM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 165 MLSLAIGIALTFAVRGEVSKPSRVRFSI----PRNVFLLSAANFIVLAAFFgLLTFLVSFLVNSGVSLKTASLLFSLLSV 240
Cdd:cd17335 166 LLALLLALKFPFRPKHPEPNENTGGLLAllrnPRVLAFLLVAFLMGFGHGL-IYSFLFWHLQDLGGSKTLIGLLWTVGVV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 241 IGITGSLVGGGLYDRIGRRSV-AVVFGLNALLTLILALTASPWVIIPL----GITFYSVGAIVTAYTSEKATGENLGSVM 315
Cdd:cd17335 245 SEIPFFFFSSRLIQRFGHVGLlYLGLLAYVVRWLLYSFLENPWLVLPIellhGLTFALVWAAAVSYASAAAPPGLRATAQ 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1900934710 316 GFVNMVGF-FGATVGPYAVGLLIDHFGYEKAFLSIPAMYLLAGVL 359
Cdd:cd17335 325 GLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLA 369
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
60-261 |
3.02e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 42.34 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 60 GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWE--------LLAVRALYGLFSGLYYAPATALISEVYRERKGSALGV 131
Cdd:cd17366 61 GPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATigvwapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 132 FM-VGPPVGSGIAPLIVVPIAVNLE--------WRYAFLALSMLSLaIGIALtfavrgevskpsrvrfsipRNVFLLSAA 202
Cdd:cd17366 141 WLeFGTLAGFILGAGLVTLLTLLLTeaqmldwgWRIPFLIAAPLGL-VGLYL-------------------RRPLLICIG 200
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1900934710 203 NFIVL-AAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSV 261
Cdd:cd17366 201 LVLVFnVTNYMLLSYMPSYLEETlGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPV 261
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
60-264 |
3.29e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 42.36 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 60 GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWE--------LLAVRALYGLFSGLYYAPATALISEVYRERKGSALGV 131
Cdd:cd17368 61 GAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATigiaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 132 F-----MVGPPVGSGIAPL--IVVPIAVNLE--WRYAFLaLSMLSLAIGIALTFAVRGEVSKPSRVRFSIPRNVFLLSAA 202
Cdd:cd17368 141 WqsasqQVAIVAGALVGYLlsLTLTAEALAEwgWRIPFF-IGLLIIPLGLWLRRSLEETEAFLERKARPTRRELFALLAN 219
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1900934710 203 NFIVLAAFFGLL-----TFLVSFLVNS-------GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVV 264
Cdd:cd17368 220 NRRIILLGMLLVagstvTFYFTTVYTPtyaktvlGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLV 293
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
1-178 |
3.79e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 3.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 1 MRKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAeaGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYS 80
Cdd:cd17489 191 LVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA--GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLA 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 81 LSSALIVFAREYWELLAVRALYGL-FSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYA 159
Cdd:cd17489 269 LGLLLLSFAGSPWMLLLAAVLYGLgFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAM 348
|
170
....*....|....*....
gi 1900934710 160 FLALSMLSLAIGIALTFAV 178
Cdd:cd17489 349 FLLAAVVVLLALVLYIFLL 367
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
65-264 |
3.82e-04 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 42.00 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 65 RFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGVFMVGppvGSGIAP 144
Cdd:PRK10091 64 RYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVS---GMTVAN 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 145 LIVVP----IAVNLEWRYAFLALSMLSLAIGIALTFAVRGEVSKPS-----RVRFSIPRNVFLLSAANFIVLAAFFGLLT 215
Cdd:PRK10091 141 LLGIPlgtyLSQEFSWRYTFLLIAVFNIAVLASIYFWVPDIRDEAKgglreQFHFLRSPAPWLIFAATMFGNAGVFAWFS 220
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1900934710 216 FLVSFLVN-SGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVV 264
Cdd:PRK10091 221 YIKPYMMFiSGFSETSMTFIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAV 270
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
21-176 |
5.43e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.39 E-value: 5.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 21 MAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWeLLAVRA 100
Cdd:cd17478 212 SSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW-SYILLV 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1900934710 101 LYGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLsLAIGIALTF 176
Cdd:cd17478 291 LAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALL-PLLGALLAF 365
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
4-252 |
7.25e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 41.83 E-value: 7.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 4 RLLLLVSLGWVFNYAHRMAIPPLIPMI--KAELGINNAEAGLLMttlLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:PRK08633 13 PLLLTQFLNAFNDLGHKILIQNTLIKAydGSEQVILTAIVNALF---LLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFA---REYWELLAVRALYGLFSGLyYAPATA-LISEVY-RERKGSALGVF--------MVGPPVGSGIAPLIVV 148
Cdd:PRK08633 90 LTLLIVLAyylGWFWLAFAVTFLLGAQSAI-YSPAKYgIIPELVgKENLSRANGLLeaftivaiLAGTALFSFLFESVNG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 149 PIAVNLEWRYAFLALSMLSLA-IGIALTFAVR----GEVSKPSRVRFSIP----RNVFLLSAANFIVLAAF--------- 210
Cdd:PRK08633 169 NTPSEILGRIAPAGLVLLAVAvLGLIFAYRLPkvpaAAPEVFDKKKYLFPkllwRNLKLLRSDRVLWLAIIglsyfwfis 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1900934710 211 -FGLLTFLVSFLVNSGVSLKTASLLFSLLSVIGI-TGSLVGGGL 252
Cdd:PRK08633 249 qLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIgIGSLLAGRL 292
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
60-266 |
8.27e-04 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 40.95 E-value: 8.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 60 GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREY-----WE---LLAVRALYGLFSGLYYAPATALISEVYRE-RKG---S 127
Cdd:PRK10406 84 GRIADKHGRKKSMLISVCMMCFGSLVIACLPGYetigtWApalLLLARLFQGLSVGGEYGTSATYMSEVAVEgRKGfyaS 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 128 ALGVFMVGppvGSGIAPLIVVPIAVNLE--------WRYAFlALSMLSLAIGIALTFAVRGEVSKPSRVRFSIP--RNVF 197
Cdd:PRK10406 164 FQYVTLIG---GQLLALLVVVVLQQTLEdaelrewgWRIPF-ALGAVLAVVALWLRRQLDETSQQETRALKEAGslKGLW 239
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1900934710 198 LLSAANFIVLA-------AFFGLLTFLVSFLVN-SGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFG 266
Cdd:PRK10406 240 RNRRAFIMVLGftaagslCFYTFTTYMQKYLVNtAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFG 316
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
154-361 |
8.48e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 41.06 E-value: 8.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 154 LEWRYAFLALSMLSLAIGIALTFAVRGEVS--KPSRVRFSIPRNVFL--------LSAANFIVL--AAFFGLLTFLVSFL 221
Cdd:cd17485 155 IGWQSLLLSLAALYLLLLLPVLFLRELELPqqPPASERGAALKASLRaflrrpgtRWLLLFLLLykLGEQGALAMLPPFL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 222 VNSGVSLKTASLLFSLL-SVIGITGSLVGGGLYDRIGRRSVAVVFGLN--------ALLTLILALTASPWVIIPLGITFY 292
Cdd:cd17485 235 VDRGFSLSQIGLLSGVGgSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLrllllglyTLLALGGSGLNWVLLLASLALLHL 314
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1900934710 293 SVGAIVTA-------YTSEKATGEN---LGSVMGFVNMVGFFgatvgpyAVGLLIDHFGYEKAFLSIPAMYLLAGVLVK 361
Cdd:cd17485 315 VGGMITTAlftlmmdCSQQAQAGTDytlLATVEVLGKLLFGS-------LAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-177 |
9.61e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 9.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 2 RKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSL 81
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 82 SSALIVFAREYWELLAVRALYGLFSGLYYAPATALI-SEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLqLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 1900934710 161 LALSMLSLAIGIALTFA 177
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
5-174 |
1.05e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.61 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 5 LLLLVSLGWVFNYAHRMAIPPLIpmiKAELGINNAEAGLLMTTLllpyALIQVP----AGYIGDRFGRKRLLVLSIIGYS 80
Cdd:cd17471 204 LFAAFTLLFAANSMYIIAMPLYV---TNELGGSESWVGLLFGLA----AALEIPimllAGLLAKRFGKRRLLLAGFLAGV 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 81 LSSALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAF 160
Cdd:cd17471 277 LFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVF 356
|
170
....*....|....
gi 1900934710 161 LALSMLSLAIGIAL 174
Cdd:cd17471 357 LVCAVLALLALVLL 370
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
35-178 |
1.08e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 40.64 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 35 GINNAEAGLLMTTLL-LPYALIqVPAGYIGDRF-GRKRLLVLSIIGYSLSSALIVFAREY-WELLAVRALYGLFSGLYYA 111
Cdd:cd17346 36 GFSEADAASIYGAYTaLVYLTP-IIGGWLADKVlGARRTVFIGGILMALGYLLLALSPFSvSMLYLGLALIIVGNGLFKP 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 112 PATALISEVYRE---RKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLAlsmlsLAIGIALTFAV 178
Cdd:cd17346 115 NISSLVGKLYDEndpRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYGYHYGFGL-----AAVGMLLGLLI 179
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-144 |
1.15e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 1 MRKRLLLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYS 80
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI 276
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1900934710 81 LSS---ALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY-RERKGSALGVFMVGPPVGSGIAP 144
Cdd:pfam07690 277 LAAlglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLApKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
59-147 |
1.31e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 40.43 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 59 AGYIGDRFGRKRLLVLSIIGYSLSS----ALIVFAREYWELLAVRALYGLFSGLYYAPATALISEVY--RERKGSALGVF 132
Cdd:cd17368 278 GGALSDRIGRRPVLLVITLAALVTLypvfAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFpvRVRSTGFSLVY 357
|
90
....*....|....*
gi 1900934710 133 MVGPPVGSGIAPLIV 147
Cdd:cd17368 358 ALAVAIFGGFAQFIV 372
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
40-181 |
1.37e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.52 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 40 EAGLLMTTLLLPYALIQVPA-------GYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYAP 112
Cdd:COG2270 268 VLGFSTTELIVFGLLVQIVAalgallfGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQAL 347
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1900934710 113 ATALISE-VYRERKGSALGVFMVGPPVGSGIAPLIV-VPIAVNLEWRYAFLALSMLsLAIGIALTFAVRGE 181
Cdd:COG2270 348 SRSLLARlIPPGREAEFFGLYALSGKAASFLGPLLFgLVTQLTGSQRLGILSLIVF-FVIGLVLLLRVKVP 417
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
31-179 |
1.44e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 31 KAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYY 110
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMF 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1900934710 111 APATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFAVR 179
Cdd:COG0738 318 PTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
6-176 |
2.83e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 39.44 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 6 LLLVSLGWVFNYAHRMAIPPLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSAL 85
Cdd:cd17372 1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 86 IVFAREYWELLAVRALYGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYaFLALSM 165
Cdd:cd17372 81 SAFAPNYMWLIILRCLVGLGLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRW-LLAFSS 159
|
170
....*....|.
gi 1900934710 166 LSLAIGIALTF 176
Cdd:cd17372 160 VPSSLLLVFYR 170
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
35-119 |
3.06e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 39.26 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 35 GINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLFSGLYYAPAT 114
Cdd:cd17362 35 NLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAP 114
|
....*
gi 1900934710 115 ALISE 119
Cdd:cd17362 115 VYIAE 119
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-177 |
4.35e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 31 KAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFA-REYWELLAVRALYGLFSGLY 109
Cdd:cd17371 237 TGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLpLSPTLILILGFPLGFFASGP 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1900934710 110 YAPATALISEVY-RERKGSALGVFMVGPPVGSGIAPLIVVPIAVNLEWRYAFLALSMLSLAIGIALTFA 177
Cdd:cd17371 317 FSGMGAYLTELFpTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
26-255 |
4.37e-03 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 38.72 E-value: 4.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 26 LIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLF 105
Cdd:PRK03545 31 LLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 106 SGLYYAPATALISEVYRERKGS-ALGVFMVGppvgSGIAPLIVVP----IAVNLEWRYAFLALSMLSLAIGIALTFAVRG 180
Cdd:PRK03545 111 HAIFWSITASLAIRVAPAGKKAqALSLLATG----TALAMVLGLPlgrvIGQYLGWRTTFLAIGGGALITLLLLIKLLPL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 181 EVSKPSRVRFSIP---RNVFLLS--AANFIVLAAFFGLLTFLVSFLVN-SGVSLKTASLLFSLLSVIGITGSLVGGGLYD 254
Cdd:PRK03545 187 LPSEHSGSLKSLPllfRRPALVSlyLLTVVVVTAHFTAYSYIEPFVQQvAGLSENFATLLLLLFGGAGIIGSVLFSRLGN 266
|
.
gi 1900934710 255 R 255
Cdd:PRK03545 267 R 267
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
23-360 |
4.98e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.36 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 23 IPPLIPMIKAELGINNAEAGLLMTTlllpYALIQV----PAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAV 98
Cdd:cd17390 15 ILPLLSTHIRSLGASPTVIGLIGSV----YGALQLfsspLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 99 RALYGLFSGlYYAPATALISEVYRERKGS-ALGV--------FMVGPPVGSGIAplivvpiavnlEWRYAFLALSMLSLA 169
Cdd:cd17390 91 RIPLGIFKH-TQSLCKAYLSDLVSEQERSrVLGRfnaasslgFILGPVVGGHLA-----------ETDGGFYYVALLCSA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 170 IGIALTFAVrgevskpsRVRFSIPRNVFLLSAANFIVLAAFFGllTFLVSFLVNSGVSLKTASLLFSLLSVIGITGSLVG 249
Cdd:cd17390 159 IFILNAGLV--------WFLLSKLWDLLLVRFLMGFSVLLFRS--NFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 250 GGLYDRIGRRSVAVVFGLNALLTLILALTA---SPWVIIpLGITFYSVGAIV-----TAYTSEKATGENLGSVMGFVNMV 321
Cdd:cd17390 229 GRILKLYKNNEYLLLLHSFILLALSLLGLAlapSIWLLV-LCLTPLSISSAVlrtcsTSLLLSRGKSKERGTLLGVGQSV 307
|
330 340 350
....*....|....*....|....*....|....*....
gi 1900934710 322 GFFGATVGPYAVGLLIDHFGYEKAFLSipAMYLLAGVLV 360
Cdd:cd17390 308 TSLARILAPLLSGLLQEFSVSGPGLLG--AVLALAAILL 344
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-215 |
5.46e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 38.33 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 29 MIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFAREYWELLAVRALYGLfsGL 108
Cdd:PRK11043 31 AIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAV--GV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 109 YYAPAT--ALISEVYRERKgsALGVF-MVGPPVG--SGIAPLIVVPIAVNLEWRYAFLALSMLSLAIgIALTFA----VR 179
Cdd:PRK11043 109 CSAAVIwqALVIDRYPAQK--ANRVFaTIMPLVAlsPALAPLLGAWLLNHFGWQAIFATLFAITLLL-ILPTLRlkpsKK 185
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1900934710 180 GEVSKPSRVRF-SIPR------NVFLLSAANfivlAAFFGLLT 215
Cdd:PRK11043 186 ARKQSQDALTFkQLLKsktylgNVLIFAACS----AAFFAWLT 224
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
23-139 |
6.03e-03 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 38.19 E-value: 6.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 23 IPPL--IPMIkAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVF--AREYWELLAV 98
Cdd:cd17422 201 APQLyiIPLS-LSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFpfAYGFWSLLVC 279
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1900934710 99 RALYGLFSGLYYAPATALISE---VYRERKGSALGVFM--------VGPPVG 139
Cdd:cd17422 280 SIFYGFMFGTVAGTHIPLLAEddvVGIEKMSSALGVYVfiqsiaglAGPPLG 331
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
59-360 |
6.11e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 38.25 E-value: 6.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 59 AGYIGDRFGRKRLLVLSIIGYSLSSAL-IVFARE---YWELL---AVRAL-YGLFSglyYAPATALISEVYRERKGSALG 130
Cdd:cd17337 52 SGVLAELFGPRRVMLIGLIIWLVFEVLfLAFGLPshnYPLMLltyGLRGFgYPLFA---YSFLVWITYRTPAERLGSAVG 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 131 ----VFMVGPPV-GSGIAPLIVVPIAVnlewrYAFLALSMLSLAIGIALT-FAVRGEVSKPSRVRFSIPRNVFLLS---- 200
Cdd:cd17337 129 wfwfAFTGGLPVlGSYLASFTIPVIGE-----IGTLWLSLVFVALGGLIAlFLVRDRTGEQPLANPSEEPLKELLSgiti 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 201 -------AANFIV----LAAFFGLLTFLVSFLVNS-GVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRRSVAVVFGLN 268
Cdd:cd17337 204 lfrnpkiAIGGIVriinTLSQFGFPVFMPLYFTDTgGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGV 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 269 ALLTLILALTASP-------WVIIPLGITFysvGAIVTAYTSEKA-----TGENLGSVMGFVNMVGFFGATVGPYAVGLL 336
Cdd:cd17337 284 GCAISTLLFYYVPqlfghnyWAALIAAILF---GIGLAGFVPLSAlmpslAPEHKGAAMSILNLGAGLSNFVGPAIVTLF 360
|
330 340
....*....|....*....|....
gi 1900934710 337 IDHFGYEKAFLSIPAMYLLAGVLV 360
Cdd:cd17337 361 LGSFGAGGVVWIFAGLYLLSAVLT 384
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
25-108 |
7.58e-03 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 37.97 E-value: 7.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 25 PLIPMIKAELGINNAEAGLLMTTLLLPYALIQVPAGYIGDRFGRKRLLVLSIIGYSLSSALIVFA---REYWELLAvrAL 101
Cdd:cd17394 20 ILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALLFIPAaslRTYGLFLI--AL 97
|
....*..
gi 1900934710 102 YGLFSGL 108
Cdd:cd17394 98 FVLASGL 104
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
64-362 |
8.61e-03 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 37.79 E-value: 8.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 64 DRFGRKRLLVLSIIGYSLSSALIVFAREYWEL-LAVRALYGLFSGLYYAPATALISEVYRERKGSALGVFMVGPPVG-SG 141
Cdd:cd17430 63 NRFGCRPVMLVGGLLASLGMILASFCTSIIQLyLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFlSA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 142 IAPLIVVpIAVNLEWRYAFLALSmlslaiGIALTFAVRGEVSKPSRVRFSIPRNVFLLSAANFIVLAAFFGLLTFLVSFL 221
Cdd:cd17430 143 LSPLGQI-LLEEYGWRGGFLILG------GLLLNCCTCGAVMRPLDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYA 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900934710 222 VNSGVSLKTASLLFSLLSVIGITGSLVGGGLYDRIGRR-------SVAVVFGLNALLTLILALTASPWVI--IPLGITFY 292
Cdd:cd17430 216 KDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRprvvylfSFAMLFNGLTDLCSATAADYGGLVVfcVFFGISYG 295
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1900934710 293 SVGAIVTAYTSEKATGENLGSVMGFVNMVGFFGATVGPYAVGLLIDHFG-YEKAFLSIPAMYLLAGVLVKL 362
Cdd:cd17430 296 MVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKnYELIFYLAGSEVVLSALFLAL 366
|
|
| |
