NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|12655466|emb|CAC27585|]
View 

keratin associated protein 9.2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 39-174 1.70e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 59.42  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12655466    39 QPACCVSSCCQP-CCRPTSCQNTCCRTTCCQPTCvTSCCQPSCCSTPCCQPTCCGSSCCGQTSCGSSCGQSSSCAPVYCR 117
Cdd:pfam01500  26 QPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCR 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12655466   118 RTCYYPTTvCLPGCLNQSCgsnCCQPCCRPACCETTCCRTTCfqptCVSSCCQPSCC 174
Cdd:pfam01500 105 PDCRVEGT-CLPPCCVVSC---TPPTCCQLHHAQASCCRPSY----CGQSCCRPACC 153
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 39-174 1.70e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 59.42  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12655466    39 QPACCVSSCCQP-CCRPTSCQNTCCRTTCCQPTCvTSCCQPSCCSTPCCQPTCCGSSCCGQTSCGSSCGQSSSCAPVYCR 117
Cdd:pfam01500  26 QPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCR 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12655466   118 RTCYYPTTvCLPGCLNQSCgsnCCQPCCRPACCETTCCRTTCfqptCVSSCCQPSCC 174
Cdd:pfam01500 105 PDCRVEGT-CLPPCCVVSC---TPPTCCQLHHAQASCCRPSY----CGQSCCRPACC 153
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
47-96 1.77e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 37.99  E-value: 1.77e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 12655466  47 CCQPCCRptsCQNTCCRTTCCQPTCVTSCCQPSCCstpCCQPTCCGSSCC 96
Cdd:COG3901 634 CCCGCCC---CCCKCCCIVIIIDGIIIINECCCCC---CLCCRRCQDDPL 677
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 39-174 1.70e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 59.42  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12655466    39 QPACCVSSCCQP-CCRPTSCQNTCCRTTCCQPTCvTSCCQPSCCSTPCCQPTCCGSSCCGQTSCGSSCGQSSSCAPVYCR 117
Cdd:pfam01500  26 QPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCR 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12655466   118 RTCYYPTTvCLPGCLNQSCgsnCCQPCCRPACCETTCCRTTCfqptCVSSCCQPSCC 174
Cdd:pfam01500 105 PDCRVEGT-CLPPCCVVSC---TPPTCCQLHHAQASCCRPSY----CGQSCCRPACC 153
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
51-96 1.25e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 1.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 12655466    51 CCRPTSCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQPTCCGSSCC 96
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQP----SCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
39-79 7.07e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.91  E-value: 7.07e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 12655466    39 QPACCVSSCCQP-CCRPTSCQNTCCRTTCCQPTC-VTSCCQPS 79
Cdd:pfam13885   3 QPSCCQPSCCQPsCCQPSCCQPSCCQPSCCRPSCcRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
80-124 6.79e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.82  E-value: 6.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 12655466    80 CCSTPCCQPTCCGSSCCGQTSCGSSCGQSSSCAPVYCRRTCYYPT 124
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
47-96 1.77e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 37.99  E-value: 1.77e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 12655466  47 CCQPCCRptsCQNTCCRTTCCQPTCVTSCCQPSCCstpCCQPTCCGSSCC 96
Cdd:COG3901 634 CCCGCCC---CCCKCCCIVIIIDGIIIINECCCCC---CLCCRRCQDDPL 677
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-96 3.03e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 36.69  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12655466     2 THCCSPCCQPTCCRTTCCRTTCWKPTTVTTCSSTSCCQPACCVSSCCQPCCRPTSCQNTCCRTTCCQPT-CVTSCCQPSC 80
Cdd:pfam01500  48 TTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPcCVVSCTPPTC 127

                          90       100
                  ....*....|....*....|.
gi 12655466    81 CST-----PCCQPTCCGSSCC 96
Cdd:pfam01500 128 CQLhhaqaSCCRPSYCGQSCC 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH