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Conserved domains on  [gi|4007010|emb|CAA66723|]
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l(2)dlt [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-382 9.00e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 9.00e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   41 PIFSAKFANCdgyRHILAIANEDGKITLQDTtqrNHQPEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVA 120
Cdd:cd00200  11 GVTCVAFSPD---GKLLATGSGDGTIKVWDL---ETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  121 GSGIrgLNSYVGHTRSVKSAAFKRTDPaVFATGGRDGAILIWDIRANlnmdltsrvdNCIYS--GHTGgpgtpvsqrkqr 198
Cdd:cd00200  82 TGEC--VRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG----------KCLTTlrGHTD------------ 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  199 trtpkmaggttssSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYkkeplprhklpyagssTFRGFTN----LIVDA 274
Cdd:cd00200 137 -------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA----------------TLTGHTGevnsVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  275 SGTRLYANCMDNTIYCYNLAsySPRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTV 354
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLR-TGECVQTLSGHTN 262

                       330       340
                ....*....|....*....|....*...
gi 4007010  355 EVTCVAWgSSHDCPIVTCSDDARHKIWR 382
Cdd:cd00200 263 SVTSLAW-SPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-382 9.00e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 9.00e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   41 PIFSAKFANCdgyRHILAIANEDGKITLQDTtqrNHQPEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVA 120
Cdd:cd00200  11 GVTCVAFSPD---GKLLATGSGDGTIKVWDL---ETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  121 GSGIrgLNSYVGHTRSVKSAAFKRTDPaVFATGGRDGAILIWDIRANlnmdltsrvdNCIYS--GHTGgpgtpvsqrkqr 198
Cdd:cd00200  82 TGEC--VRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG----------KCLTTlrGHTD------------ 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  199 trtpkmaggttssSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYkkeplprhklpyagssTFRGFTN----LIVDA 274
Cdd:cd00200 137 -------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA----------------TLTGHTGevnsVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  275 SGTRLYANCMDNTIYCYNLAsySPRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTV 354
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLR-TGECVQTLSGHTN 262

                       330       340
                ....*....|....*....|....*...
gi 4007010  355 EVTCVAWgSSHDCPIVTCSDDARHKIWR 382
Cdd:cd00200 263 SVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
54-383 3.70e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 3.70e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   54 RHILAIANEDGKITLQDTTQRnhqpeeQSLVGPQCHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAgSGiRGLNSYVGH 133
Cdd:COG2319  90 GRLLASASADGTVRLWDLATG------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TG-KLLRTLTGH 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  134 TRSVKSAAFkRTDPAVFATGGRDGAILIWDIR-----ANLNmDLTSRVDNCIYS--GHT----GGPGT----PVSQRKQR 198
Cdd:COG2319 162 SGAVTSVAF-SPDGKLLASGSDDGTVRLWDLAtgkllRTLT-GHTGAVRSVAFSpdGKLlasgSADGTvrlwDLATGKLL 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  199 TRTPkmaggTTSSSITGLAFQDNDTLISCGAGDGVIKVWDLRrnyTAYKKEPLPRHKlpyagsstfRGFTNLIVDASGTR 278
Cdd:COG2319 240 RTLT-----GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHS---------GGVNSVAFSPDGKL 302

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  279 LYANCMDNTIYCYNLASysPRPLACYKGllnSTFYIKS-CLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTVEVT 357
Cdd:COG2319 303 LASGSDDGTVRLWDLAT--GKLLRTLTG---HTGAVRSvAFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVT 376

                       330       340
                ....*....|....*....|....*.
gi 4007010  358 CVAWgSSHDCPIVTCSDDARHKIWRI 383
Cdd:COG2319 377 SVAF-SPDGRTLASGSADGTVRLWDL 401
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 107-305 2.36e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 2.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   107 SASGDHTARLWEVAGSGIrgLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILIWDIRANLNMDLTSRVDN--CIYSGH 184
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQL--VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANicCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   185 TGGPGTPVSQRKQRT-----RTPKMAGGTT---SSSITGLAFQDNDTLIScGAGDGVIKVWDLRRNYTAYKKEPLprHKl 256
Cdd:PLN00181 628 ESGRSLAFGSADHKVyyydlRNPKLPLCTMighSKTVSYVRFVDSSTLVS-SSTDNTLKLWDLSMSISGINETPL--HS- 703

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4007010   257 pYAGSSTFRGFTNLIVD----ASGTRlyancmDNTIYCYNLAsySPRPLACYK 305
Cdd:PLN00181 704 -FMGHTNVKNFVGLSVSdgyiATGSE------TNEVFVYHKA--FPMPVLSYK 747
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-381 2.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 2.35e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4007010     344 EPLVALAGHTVEVTCVAWgSSHDCPIVTCSDDARHKIW 381
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
344-381 7.78e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.78e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4007010    344 EPLVALAGHTVEVTCVAWGSSHDCpIVTCSDDARHKIW 381
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-382 9.00e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 9.00e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   41 PIFSAKFANCdgyRHILAIANEDGKITLQDTtqrNHQPEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVA 120
Cdd:cd00200  11 GVTCVAFSPD---GKLLATGSGDGTIKVWDL---ETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  121 GSGIrgLNSYVGHTRSVKSAAFKRTDPaVFATGGRDGAILIWDIRANlnmdltsrvdNCIYS--GHTGgpgtpvsqrkqr 198
Cdd:cd00200  82 TGEC--VRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG----------KCLTTlrGHTD------------ 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  199 trtpkmaggttssSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYkkeplprhklpyagssTFRGFTN----LIVDA 274
Cdd:cd00200 137 -------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA----------------TLTGHTGevnsVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  275 SGTRLYANCMDNTIYCYNLAsySPRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTV 354
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLR-TGECVQTLSGHTN 262

                       330       340
                ....*....|....*....|....*...
gi 4007010  355 EVTCVAWgSSHDCPIVTCSDDARHKIWR 382
Cdd:cd00200 263 SVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
54-383 3.70e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 3.70e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   54 RHILAIANEDGKITLQDTTQRnhqpeeQSLVGPQCHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAgSGiRGLNSYVGH 133
Cdd:COG2319  90 GRLLASASADGTVRLWDLATG------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TG-KLLRTLTGH 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  134 TRSVKSAAFkRTDPAVFATGGRDGAILIWDIR-----ANLNmDLTSRVDNCIYS--GHT----GGPGT----PVSQRKQR 198
Cdd:COG2319 162 SGAVTSVAF-SPDGKLLASGSDDGTVRLWDLAtgkllRTLT-GHTGAVRSVAFSpdGKLlasgSADGTvrlwDLATGKLL 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  199 TRTPkmaggTTSSSITGLAFQDNDTLISCGAGDGVIKVWDLRrnyTAYKKEPLPRHKlpyagsstfRGFTNLIVDASGTR 278
Cdd:COG2319 240 RTLT-----GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHS---------GGVNSVAFSPDGKL 302

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  279 LYANCMDNTIYCYNLASysPRPLACYKGllnSTFYIKS-CLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTVEVT 357
Cdd:COG2319 303 LASGSDDGTVRLWDLAT--GKLLRTLTG---HTGAVRSvAFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVT 376

                       330       340
                ....*....|....*....|....*.
gi 4007010  358 CVAWgSSHDCPIVTCSDDARHKIWRI 383
Cdd:COG2319 377 SVAF-SPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
68-383 3.66e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 3.66e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   68 LQDTTQRNHQPEEQSLVGPQCHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAGSGIrgLNSYVGHTRSVKSAAFKRtDP 147
Cdd:COG2319  56 GDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL--LRTLTGHTGAVRSVAFSP-DG 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  148 AVFATGGRDGAILIWDIR-----ANLNMDlTSRVDNCIYS--GHT----GGPGT-----PVSQRKQRTRTPkmaggtTSS 211
Cdd:COG2319 133 KTLASGSADGTVRLWDLAtgkllRTLTGH-SGAVTSVAFSpdGKLlasgSDDGTvrlwdLATGKLLRTLTG------HTG 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  212 SITGLAFQDNDTLISCGAGDGVIKVWDLRRNytaykkEPLprhklpyagsSTFRGFTNLIVDAS----GTRLYANCMDNT 287
Cdd:COG2319 206 AVRSVAFSPDGKLLASGSADGTVRLWDLATG------KLL----------RTLTGHSGSVRSVAfspdGRLLASGSADGT 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  288 IYCYNLAsySPRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTVEVTCVAWgSSHDC 367
Cdd:COG2319 270 VRLWDLA--TGELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAF-SPDGK 343

                       330
                ....*....|....*.
gi 4007010  368 PIVTCSDDARHKIWRI 383
Cdd:COG2319 344 TLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
51-340 4.54e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   51 DGyrHILAIANEDGKITLQDTTQRNhqpEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAGSgiRGLNSY 130
Cdd:COG2319 173 DG--KLLASGSDDGTVRLWDLATGK---LLRTLTG---HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTL 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  131 VGHTRSVKSAAFkRTDPAVFATGGRDGAILIWDiranlnmdLTSRVDNCIYSGHTGGpgtpvsqrkqrtrtpkmaggtts 210
Cdd:COG2319 243 TGHSGSVRSVAF-SPDGRLLASGSADGTVRLWD--------LATGELLRTLTGHSGG----------------------- 290

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  211 ssITGLAF-QDNDTLIScGAGDGVIKVWDLRRNytaykkEPLprhklpyagsSTFRGFTNLIVDAS----GTRLYANCMD 285
Cdd:COG2319 291 --VNSVAFsPDGKLLAS-GSDDGTVRLWDLATG------KLL----------RTLTGHTGAVRSVAfspdGKTLASGSDD 351

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4007010  286 NTIYCYNLASysPRPLACYKGllnSTFYIKS-CLSPDGKYLLSGSSDERAYIWNLD 340
Cdd:COG2319 352 GTVRLWDLAT--GELLRTLTG---HTGAVTSvAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
89-383 9.79e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 9.79e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   89 HFNAVFDLEWAPGQMRFVSASGDHTARLWEVAGSgiRGLNSYVGHTRSVKSAAFKRtDPAVFATGGRDGAILIWDiranl 168
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG--ALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWD----- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  169 nmdLTSRVDNCIYSGHTGgpgtpvsqrkqrtrtpkmaggttssSITGLAFQDNDTLISCGAGDGVIKVWDLRRnytaykK 248
Cdd:COG2319 107 ---LATGLLLRTLTGHTG-------------------------AVRSVAFSPDGKTLASGSADGTVRLWDLAT------G 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  249 EPLprhklpyagsSTFRGFTNLIVDAS----GTRLYANCMDNTIYCYNLASysPRPLACYKGllnSTFYIKS-CLSPDGK 323
Cdd:COG2319 153 KLL----------RTLTGHSGAVTSVAfspdGKLLASGSDDGTVRLWDLAT--GKLLRTLTG---HTGAVRSvAFSPDGK 217

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4007010  324 YLLSGSSDERAYIWNLDhAEEPLVALAGHTVEVTCVAWgsSHDCP-IVTCSDDARHKIWRI 383
Cdd:COG2319 218 LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAF--SPDGRlLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
185-383 7.56e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 7.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  185 TGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLISCGAGDGVIKVWDLRRNytaykkeplprhKLPYAGSSTF 264
Cdd:COG2319  11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG------------ALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010  265 RGFTNLIVDASGTRLYANCMDNTIYCYNLASysPRPLACYKGLlnsTFYIKSC-LSPDGKYLLSGSSDERAYIWNLDHAE 343
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLAT--GLLLRTLTGH---TGAVRSVaFSPDGKTLASGSADGTVRLWDLATGK 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4007010  344 EpLVALAGHTVEVTCVAWgsSHD-CPIVTCSDDARHKIWRI 383
Cdd:COG2319 154 L-LRTLTGHSGAVTSVAF--SPDgKLLASGSDDGTVRLWDL 191
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 107-305 2.36e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 2.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   107 SASGDHTARLWEVAGSGIrgLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILIWDIRANLNMDLTSRVDN--CIYSGH 184
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQL--VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANicCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4007010   185 TGGPGTPVSQRKQRT-----RTPKMAGGTT---SSSITGLAFQDNDTLIScGAGDGVIKVWDLRRNYTAYKKEPLprHKl 256
Cdd:PLN00181 628 ESGRSLAFGSADHKVyyydlRNPKLPLCTMighSKTVSYVRFVDSSTLVS-SSTDNTLKLWDLSMSISGINETPL--HS- 703

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4007010   257 pYAGSSTFRGFTNLIVD----ASGTRlyancmDNTIYCYNLAsySPRPLACYK 305
Cdd:PLN00181 704 -FMGHTNVKNFVGLSVSdgyiATGSE------TNEVFVYHKA--FPMPVLSYK 747
WD40 COG2319
WD40 repeat [General function prediction only];
51-121 1.37e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.37e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4007010   51 DGyrHILAIANEDGKITLQDTTQRnhqPEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAG 121
Cdd:COG2319 341 DG--KTLASGSDDGTVRLWDLATG---ELLRTLTG---HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-381 2.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 2.35e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4007010     344 EPLVALAGHTVEVTCVAWgSSHDCPIVTCSDDARHKIW 381
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
344-381 7.78e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.78e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4007010    344 EPLVALAGHTVEVTCVAWGSSHDCpIVTCSDDARHKIW 381
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
210-238 8.33e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 8.33e-04
                          10        20
                  ....*....|....*....|....*....
gi 4007010    210 SSSITGLAFQDNDTLISCGAGDGVIKVWD 238
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 127-163 1.28e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 4007010     127 LNSYVGHTRSVKSAAFKRTDPaVFATGGRDGAILIWD 163
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 210-238 1.56e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.56e-03
                           10        20
                   ....*....|....*....|....*....
gi 4007010     210 SSSITGLAFQDNDTLISCGAGDGVIKVWD 238
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 87-118 1.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4007010      87 QCHFNAVFDLEWAPGQMRFVSASGDHTARLWE 118
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
127-163 2.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 4007010    127 LNSYVGHTRSVKSAAFKRtDPAVFATGGRDGAILIWD 163
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
87-118 9.78e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 9.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 4007010     87 QCHFNAVFDLEWAPGQMRFVSASGDHTARLWE 118
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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