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Conserved domains on  [gi|550341|emb|CAA57356|]
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ornithine carbamoyltransferase [Halobacterium salinarum]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479232)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

CATH:  3.40.50.720
EC:  2.1.3.3
Gene Ontology:  GO:0004585|GO:0006591|GO:0006526
PubMed:  18062991

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 1-292 1.29e-173

ornithine carbamoyltransferase; Provisional


:

Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 481.90  E-value: 1.29e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      1 MEHLVDINDVESEEIEQLLDLAASMKENP--GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLS 78
Cdd:PRK00779   4 GRHFLSLDDLSPEELEELLDLAAELKKKRkaGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     79 RGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE-KDRLD--TLAFVGDGNN 155
Cdd:PRK00779  84 RGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEhRGSLKglKVAWVGDGNN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    156 VAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVSD---ANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLAEFD 232
Cdd:PRK00779 164 VANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIAKetgASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFA 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    233 GFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTL 292
Cdd:PRK00779 244 PYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWL 303
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 1-292 1.29e-173

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 481.90  E-value: 1.29e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      1 MEHLVDINDVESEEIEQLLDLAASMKENP--GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLS 78
Cdd:PRK00779   4 GRHFLSLDDLSPEELEELLDLAAELKKKRkaGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     79 RGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE-KDRLD--TLAFVGDGNN 155
Cdd:PRK00779  84 RGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEhRGSLKglKVAWVGDGNN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    156 VAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVSD---ANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLAEFD 232
Cdd:PRK00779 164 VANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIAKetgASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFA 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    233 GFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTL 292
Cdd:PRK00779 244 PYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWL 303
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 1-295 4.37e-168

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 467.99  E-value: 4.37e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     1 MEHLVDINDVESEEIEQLLDLAASMKENP--GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLS 78
Cdd:COG0078   5 GRHFLSLLDLTPEELRALLDLAAELKAKRkaGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDSQLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    79 RGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE-KDRLD--TLAFVGDGNN 155
Cdd:COG0078  85 RGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREhFGKLKglKVAYVGDGNN 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341   156 VAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRV------SDANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLA 229
Cdd:COG0078 165 VANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAkeiaaeSGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAEERIK 244

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550341   230 EFDGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVNQ 295
Cdd:COG0078 245 AFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 3-294 4.83e-133

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 379.39  E-value: 4.83e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341       3 HLVDINDVESEEIEQLLDLAASMKEN--PGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRG 80
Cdd:TIGR00658   2 HLLSLLDLSPEEIRYLLQLAKKLKKGkkKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGRG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      81 EPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQEK-DRLD--TLAFVGDGNNVA 157
Cdd:TIGR00658  82 ESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHfGKLKgvKVVYVGDGNNVC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     158 HSLMQASAKMGVDCRIATPEGMEPDEEIQDRV------SDANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLAEF 231
Cdd:TIGR00658 162 NSLMLAGAKLGMDVVVATPEGYEPDADIVKKAqeiakeNGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKLF 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550341     232 DGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVN 294
Cdd:TIGR00658 242 RPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
146-292 1.76e-72

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 219.79  E-value: 1.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     146 TLAFVGDG-NNVAHSLMQASAKMGVDCRIATPEGMEPDEEIQDR------VSDANVTVTNDPYEAVDGATAVYGDVFVSM 218
Cdd:pfam00185   1 KIAYVGDGhNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKakkiaeKSGGSIEITDDPAEAVKGADVVYTDVWQSM 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550341     219 GEEEQREEKLAEFDGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTL 292
Cdd:pfam00185  81 GQEKEREERLKAFKPYQVNEELMKLAKKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 1-292 1.29e-173

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 481.90  E-value: 1.29e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      1 MEHLVDINDVESEEIEQLLDLAASMKENP--GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLS 78
Cdd:PRK00779   4 GRHFLSLDDLSPEELEELLDLAAELKKKRkaGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     79 RGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE-KDRLD--TLAFVGDGNN 155
Cdd:PRK00779  84 RGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEhRGSLKglKVAWVGDGNN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    156 VAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVSD---ANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLAEFD 232
Cdd:PRK00779 164 VANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIAKetgASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFA 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    233 GFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTL 292
Cdd:PRK00779 244 PYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWL 303
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 1-295 4.37e-168

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 467.99  E-value: 4.37e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     1 MEHLVDINDVESEEIEQLLDLAASMKENP--GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLS 78
Cdd:COG0078   5 GRHFLSLLDLTPEELRALLDLAAELKAKRkaGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDSQLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    79 RGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE-KDRLD--TLAFVGDGNN 155
Cdd:COG0078  85 RGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREhFGKLKglKVAYVGDGNN 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341   156 VAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRV------SDANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLA 229
Cdd:COG0078 165 VANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAkeiaaeSGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAEERIK 244

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550341   230 EFDGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVNQ 295
Cdd:COG0078 245 AFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 3-294 4.83e-133

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 379.39  E-value: 4.83e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341       3 HLVDINDVESEEIEQLLDLAASMKEN--PGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRG 80
Cdd:TIGR00658   2 HLLSLLDLSPEEIRYLLQLAKKLKKGkkKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGRG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      81 EPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQEK-DRLD--TLAFVGDGNNVA 157
Cdd:TIGR00658  82 ESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHfGKLKgvKVVYVGDGNNVC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     158 HSLMQASAKMGVDCRIATPEGMEPDEEIQDRV------SDANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLAEF 231
Cdd:TIGR00658 162 NSLMLAGAKLGMDVVVATPEGYEPDADIVKKAqeiakeNGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKLF 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550341     232 DGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVN 294
Cdd:TIGR00658 242 RPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
PLN02342 PLN02342
ornithine carbamoyltransferase
 1-288 6.61e-119

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 344.85  E-value: 6.61e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      1 MEHLVDINDVESEEIEQLLDLAASMK-------ENPGEFSGvmdnKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMG 73
Cdd:PLN02342  45 PKHFLHIDDFDKEEILGLLDRAKEVKallksgdRSFQPFKG----KSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPD 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     74 SSQLSRGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE-KDRLD--TLAFV 150
Cdd:PLN02342 121 DIQLGKREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEhIGRLEgtKVVYV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    151 GDGNNVAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVSDA---NVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEK 227
Cdd:PLN02342 201 GDGNNIVHSWLLLAAVLPFHFVCACPKGYEPDAKTVEKARAAgisKIEITNDPAEAVKGADVVYTDVWASMGQKEEAEKR 280

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550341    228 LAEFDGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAI 288
Cdd:PLN02342 281 KKAFQGFQVNEALMKLAGPQAYFMHCLPAERGVEVTDGVMEAPNSIVFPQAENRMHAQNAI 341
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 1-295 2.77e-112

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 326.64  E-value: 2.77e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      1 MEHLVDINDVESEEIEQLLDLAASMKENPGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRG 80
Cdd:PRK14805   1 MKHLLSIKELTQQQLLDLLALAKTIKANPAEYRQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALGKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     81 EPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQEK-DRLD--TLAFVGDGNNVA 157
Cdd:PRK14805  81 ESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQfGDVSkvKLAYVGDGNNVT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    158 HSLMQASAKMGVDCRIATPEGMEPDEEI------QDRVSDANVTVTNDpYEAVDGATAVYGDVFVSMGEEEQREEKLAEF 231
Cdd:PRK14805 161 HSLMYGAAILGATMTVICPPGHFPDGQIvaeaqeLAAKSGGKLVLTSD-IEAIEGHDAIYTDTWISMGDDTPLAEIKAKF 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550341    232 DGFQIDQDLMDAArDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVNQ 295
Cdd:PRK14805 240 APYQVNKALMEKA-GATFVMHCQPAHRGVEITSEVMDGEGSLILQQAENRMHAQNAVLVTLLSQ 302
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 9-294 1.99e-109

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 320.29  E-value: 1.99e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      9 DVESEEIEQLLDLAASMKENpgEFSGV----MDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRGEPIS 84
Cdd:PRK02102  15 DFTPEEIEYLIDLSIELKAA--KKAGIehqyLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPNDSQLGKKESIE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     85 DVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQEK-DRLD--TLAFVGDG-NNVAHSL 160
Cdd:PRK02102  93 DTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHfGPLKglKLAYVGDGrNNMANSL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    161 MQASAKMGVDCRIATPEGMEPDEEIQDRV------SDANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLAEFDGF 234
Cdd:PRK02102 173 MVGGAKLGMDVRICAPKELWPEEELVALAreiakeTGAKITITEDPEEAVKGADVIYTDVWVSMGEEDEWEERIKLLKPY 252

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550341    235 QIDQDLMDA-ARDDAIFMHCLPA-----------------HRGEEVTAEVADGPQSVIFDQAENRMHVQKAI-VHTLVN 294
Cdd:PRK02102 253 QVNMDLMKAtGNPDVIFMHCLPAfhdtetkvgkeiaekygLKGLEVTDEVFESKYSIVFDEAENRMHTIKAVmVATLGD 331
putr_carbamoyl TIGR04384
putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase ...
 3-295 7.56e-100

putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase (EC 2.1.3.6). There is some overlapping specificity with ornithine carbamoyltransferase (EC 2.1.3.3). The gene regularly is found next to agmatine deiminase and a carbamate kinase, suggesting a conserved catabolic agmatine deiminase pathway. [Energy metabolism, Amino acids and amines]


Pssm-ID: 275177  Cd Length: 330  Bit Score: 295.79  E-value: 7.56e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341       3 HLVDINDVESEEIEQLLDLAASMKE--NPGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRG 80
Cdd:TIGR04384   1 DFIDTNDFTKEEILDIIDLSLKIKEaiKDGYYPPLLKNKSLGMIFEQSSTRTRVSFETAMTQLGGHAQYLAPGQIQLGGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      81 EPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE-----KDRLD-TLAFVGDGN 154
Cdd:TIGR04384  81 ESIEDTARVLSRLVDIIMARVDRHETVVELAKYATVPVINGMSDYNHPTQELGDLFTMIEhlpagKKLEDcKVVFVGDAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     155 NVAHSLMQASAKMGVDCRIATPEGMEPDEEIQD------RVSDANVTVTNDPYEAVDGATAVYGDVFVSM-GEEEQREEK 227
Cdd:TIGR04384 161 QVCVSLMFICTKMGMDFVHFGPKGYQIPEEWLAiaeancKVSGGSVTVTDDVDEAVKGADFIYTDVWYGLyDQELSEEER 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550341     228 LAEF-DGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVNQ 295
Cdd:TIGR04384 241 MAIFyPKYQVNPELMAKAGPHAKFMHCLPASRGEEVTDEVMDSPQSICFDEAENRLTAIRALLVYFLYP 309
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 9-292 1.74e-73

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 228.86  E-value: 1.74e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      9 DVESEEIEQLLDLAASMKEnpGEFSGV----MDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRGEPIS 84
Cdd:PRK04284  14 DFTPKEIEYLLDLSEDLKR--AKYAGIevqkLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPTGSQMGKKESTK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     85 DVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQEKDRLD----TLAFVGDG-NNVAHS 159
Cdd:PRK04284  92 DTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHLKKPykdiKFTYVGDGrNNVANA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    160 LMQASAKMGVDCRIATPEGMEPDEEIQDRV------SDANVTVTNDPYEAVDGATAVYGDVFVSMGE-EEQREEKLAEFD 232
Cdd:PRK04284 172 LMQGAAIMGMDFHLVCPKELNPDDELLNKCkeiaaeTGGKITITDDIDEGVKGSDVIYTDVWVSMGEpDEVWEERIKLLK 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550341    233 GFQIDQDLMDAARD-DAIFMHCLPA-H----------------RGEEVTAEVADGPQSVIFDQAENRMHVQKAI-VHTL 292
Cdd:PRK04284 252 PYQVNKEMMKKTGNpNAIFEHCLPSfHdldtkvgkeifekyglKEMEVTDEVFESKASVVFDEAENRMHTIKAVmVATL 330
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
146-292 1.76e-72

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 219.79  E-value: 1.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     146 TLAFVGDG-NNVAHSLMQASAKMGVDCRIATPEGMEPDEEIQDR------VSDANVTVTNDPYEAVDGATAVYGDVFVSM 218
Cdd:pfam00185   1 KIAYVGDGhNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKakkiaeKSGGSIEITDDPAEAVKGADVVYTDVWQSM 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550341     219 GEEEQREEKLAEFDGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTL 292
Cdd:pfam00185  81 GQEKEREERLKAFKPYQVNEELMKLAKKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 1-294 9.15e-68

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 212.99  E-value: 9.15e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     1 MEHLVDINDVESEEIEQLLDLAASMKE--NPGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLS 78
Cdd:COG0540   5 MRHLLSIEDLSREEIEELLDTAEEFKEvlRPIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSVS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    79 RGEPISDVSQVMSRY-EDAIMARLFEHDEMMELAENADVPVVNGltd-flHPCQALTDMFTM-QEKDRLD--TLAFVGDG 153
Cdd:COG0540  85 KGESLADTIRTLEAYgADAIVIRHPQEGAARLLAEHVDVPVINAgdgaheHPTQALLDLYTIrEEFGRLDglKVAIVGDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341   154 NN--VAHSLMQASAKMGVDCRIATPEGMEPDEeiqdrVSDANVTVTNDPYEAVDGATAVY----------GDVFVSmgee 221
Cdd:COG0540 165 KHsrVARSNIKALSKLGAEVTLVAPPTLLPEE-----IEELGVEVTTDLDEALPDADVVYmlriqkerftDGLFPS---- 235

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550341   222 eqrEEKLAEFdgFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVN 294
Cdd:COG0540 236 ---YREYKRS--YGLTAERLALAKPDAIVMHPGPRNRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLG 303
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 3-295 2.20e-67

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 213.04  E-value: 2.20e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      3 HLVDINDVESEEIEQLLDLAASMKENP--GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRG 80
Cdd:PRK03515   8 HFLRLLDFTPAELNSLLQLAAKLKADKknGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGHK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     81 EPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE----KDRLD-TLAFVGDG-N 154
Cdd:PRK03515  88 ESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEhlpgKAFNEmTLAYAGDArN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    155 NVAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVSDA------NVTVTNDPYEAVDGATAVYGDVFVSMGE-EEQREEK 227
Cdd:PRK03515 168 NMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALaqknggNITLTEDIAEGVKGADFIYTDVWVSMGEpKEVWAER 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    228 LAEFDGFQIDQDLMDAARDDAI-FMHCLPA------------------HRGEEVTAEVADGPQSVIFDQAENRMHVQKAI 288
Cdd:PRK03515 248 IALLRPYQVNSKMMQLTGNPQVkFLHCLPAfhddqttlgkkmaeeyglHGGMEVTDEVFESAHSIVFDQAENRLHTIKAV 327


                 ....*...
gi 550341    289 -VHTLVNQ 295
Cdd:PRK03515 328 mVATLSKD 335
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
3-140 3.34e-67

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 205.74  E-value: 3.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341       3 HLVDINDVESEEIEQLLDLAASMKENP--GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRG 80
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARkrGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      81 EPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE 140
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 1-293 2.45e-63

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 202.18  E-value: 2.45e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      1 MEHLVDINDVESEEIEQLLDLAASMKENPGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSrg 80
Cdd:PRK14804   6 VKHLISWEDWSDSEILDLLDFAVHVKKNRVNYAGHMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNFQ-- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     81 epISDV---SQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQ-EKDRLD----TLAFVGD 152
Cdd:PRK14804  84 --LSDIdleARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIAlDSPEIPlnqkQLTYIGV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    153 GNNVAHSLMQASAKMGVDCRIATP----EGMEPdEEIQDRVSDANVTVTNDPYEAVDGATAVYGDVFVSM------GEEE 222
Cdd:PRK14804 162 HNNVVNSLIGITAALGIHLTLVTPiaakENIHA-QTVERAKKKGTLSWEMNLHKAVSHADYVYTDTWLDMeffndpSYAD 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550341    223 QREEKLAEFDGFQIDQDLMDaaRDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLV 293
Cdd:PRK14804 241 KKKQRMELMMPYQINSSLME--KTNAKVMHDMPIHAGYEITREVVLSDRSIIFQQAENRLDAQKAVILKLL 309
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 1-295 1.12e-61

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 198.43  E-value: 1.12e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      1 MEHLVDINDVESEEIEQLLDLAASMKENPgeFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLS-- 78
Cdd:PRK04523   3 LKHFLNTQDWSRAELDALLTQAAAFKRNK--LGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQPGKDAWPie 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     79 ----------RGEPISDVSQVMSRYEDAIMARLF---------EHDEMME-LAENADVPVVNgLTDFLHPCQALTDMFTM 138
Cdd:PRK04523  81 felgavmdgeTEEHIREVARVLSRYVDLIGVRAFpkfvdwskdRQDQVLNsFAKYSTVPVIN-METITHPCQELAHALAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    139 QEK--DRLDTLAFVGD--------GNNVAHSLMQASAKMGVDCRIATPEgmePDEEIQDRVSDA----------NVTVTN 198
Cdd:PRK04523 160 QEHfgTTLRGKKYVLTwtyhpkplNTAVANSALLIATRLGMDVTLLCPT---PDYILDERYMDWaeqnaaesggSLTVSH 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    199 DPYEAVDGATAVYGDVFVSM---GEEEQREEKLAEFDGFQIDQDLMdAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIF 275
Cdd:PRK04523 237 DIDSAYAGADVVYAKSWGALpffGNWEPEKPIRDQYQHFIVDERKM-ALTNNGVFSHCLPLRRNVKVTDAVMDSPNCIAI 315

                        330       340
                 ....*....|....*....|
gi 550341    276 DQAENRMHVQKAIVHTLVNQ 295
Cdd:PRK04523 316 DEAENRLHVQKAIMAALASQ 335
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 3-289 1.21e-61

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 198.29  E-value: 1.21e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      3 HLVDINDVESEEIEQLLDLAASMKEnpGEFSGV----MDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLS 78
Cdd:PRK01713   9 HLLSLVNHTEREIKYLLDLSRDLKR--AKYAGTeqqrLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSSQIG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     79 RGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQE--KDRLDTLAFV--GDG- 153
Cdd:PRK01713  87 HKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIEncDKPLSEISYVyiGDAr 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    154 NNVAHSLMQASAKMGVDCRIATPEGMEPDEEIQD------RVSDANVTVTNDPYEAVDGATAVYGDVFVSMGEE-EQREE 226
Cdd:PRK01713 167 NNMGNSLLLIGAKLGMDVRICAPKALLPEASLVEmcekfaKESGARITVTDDIDKAVKGVDFVHTDVWVSMGEPlETWGE 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    227 KLAEFDGFQIDQDLMDAARDDAI-FMHCLPA-HRGE------------------EVTAEVADGPQSVIFDQAENRMHVQK 286
Cdd:PRK01713 247 RIKLLMPYQVTPELMKRTGNPKVkFMHCLPAfHNSEtkvgrqiaekypelangiEVTEDVFESPMNIAFEQAENRMHTIK 326


                 ...
gi 550341    287 AIV 289
Cdd:PRK01713 327 AVM 329
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
1-294 1.23e-60

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 194.91  E-value: 1.23e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      1 MEHLVDINDVESEEIEQLLDLAASMKENPGE---FSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQL 77
Cdd:PRK00856   5 MKHLLSIEDLSREEIELLLDTAEEFKEVLRRevkKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     78 SRGEPISDVSQVMSRYE-DAIMARlfeHDE---MMELAENADVPVVNGlTDFL--HPCQALTDMFTM-QEKDRLD--TLA 148
Cdd:PRK00856  85 SKGETLADTIRTLSAMGaDAIVIR---HPQsgaARLLAESSDVPVINA-GDGShqHPTQALLDLLTIrEEFGRLEglKVA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    149 FVGDGNN--VAHSLMQASAKMGVDCRIATPEGMEPDEEiqdrvsdANVTVTNDPYEAVDGATAVY----------GDVFV 216
Cdd:PRK00856 161 IVGDIKHsrVARSNIQALTRLGAEVRLIAPPTLLPEGM-------PEYGVHTDLDEVIEDADVVMmlrvqkermdGGLLP 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550341    217 SmgeeeqrEEKLAEFdgFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVN 294
Cdd:PRK00856 234 S-------YEEYKRS--YGLTAERLALAKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLG 302
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 2-289 2.87e-57

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 187.19  E-value: 2.87e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      2 EHLVDINDVESEEIEQLLDLAASMKENP--GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSR 79
Cdd:PRK12562   7 KHFLKLLDFTPAELNSLLQLAAKLKADKknGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     80 GEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQEK------DRLdTLAFVGDG 153
Cdd:PRK12562  87 KESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlpgkafNEM-TLVYAGDA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    154 -NNVAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVS------DANVTVTNDPYEAVDGATAVYGDVFVSMGE-EEQRE 225
Cdd:PRK12562 166 rNNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSalaqkhGGKITLTEDIAAGVKGADFIYTDVWVSMGEpKEKWA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    226 EKLAEFDGFQIDQDLMDAARDDAI-FMHCLPA------------------HRGEEVTAEVADGPQSVIFDQAENRMHVQK 286
Cdd:PRK12562 246 ERIALLRGYQVNSKMMALTGNPQVkFLHCLPAfhddqttlgkkmakefglHGGMEVTDEVFESPASIVFDQAENRMHTIK 325


                 ...
gi 550341    287 AIV 289
Cdd:PRK12562 326 AVM 328
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 2-288 3.81e-48

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 162.53  E-value: 3.81e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341       2 EHLVDINDVESEEIEQLLDLAASMKE--NPGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGI-FFEMGSSQLS 78
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQvlNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVnFSDSETSSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      79 RGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVN-GLTDFLHPCQALTDMFTMQEK-DRLD--TLAFVGDGN 154
Cdd:TIGR00670  81 KGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVSEVPVINaGDGSNQHPTQTLLDLYTIYEEfGRLDglKIALVGDLK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     155 N--VAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVSDANVTV--TNDPYEAVDGATAVYgdVFVSMGEEEQREEKLAE 230
Cdd:TIGR00670 161 YgrTVHSLAEALTRFGVEVYLISPEELRMPKEILEELKAKGIKVreTESLEEVIDEADVLY--VTRIQKERFPDPEEYEK 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 550341     231 FDG-FQIDQDLMDAARDDAIFMHCLPahRGEEVTAEVADGPQSVIFDQAENRMHVQKAI 288
Cdd:TIGR00670 239 VKGsYGITLERLEAAKKGVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFNGVPVRMAL 295
PLN02527 PLN02527
aspartate carbamoyltransferase
 2-292 2.06e-34

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 126.79  E-value: 2.06e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      2 EHLVDINDVESEEIEQLLDLAASMKE----NPGefSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMG--SS 75
Cdd:PLN02527   1 SDVIEAQQFDREMLELLFEVAREMEKvergSPG--SQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENAgeFS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     76 QLSRGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVN-GLTDFLHPCQALTDMFTMQ-EKDRLDTL--AFVG 151
Cdd:PLN02527  79 SAAKGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATAEIPVINaGDGPGQHPTQALLDVYTIQrEIGRLDGIkvGLVG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    152 DGNN--VAHSLMQASAKM-GVDCRIATPEGMEPDEEIQDRVSDANV--TVTNDPYEAVDGATAVYgdvfVSMGEEEQREE 226
Cdd:PLN02527 159 DLANgrTVRSLAYLLAKYeDVKIYFVAPDVVKMKDDIKDYLTSKGVewEESSDLMEVASKCDVLY----QTRIQRERFGE 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    227 KLAEFDG----FQIDQDLMDAARDDAIFMHCLPahRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTL 292
Cdd:PLN02527 235 RIDLYEAargkYIVDKKVMDVLPKHAVVMHPLP--RLDEITTDVDSDPRAAYFRQAKNGLFIRMALLKLL 302
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 3-293 1.58e-29

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 116.12  E-value: 1.58e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      3 HLVDINDVESEEIEQLLDLAASMK--ENPGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGhGIFFEMG--SSQLS 78
Cdd:PRK11891  89 QLLSVDQFSRDSVEALFRVADVMQpiARRQKISRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGG-SVCDTTGftFSSMA 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     79 RGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVN-GLTDFLHPCQALTDMFTMQ-EKDRLDTL------AFV 150
Cdd:PRK11891 168 KGESIYDTSRVMSGYVDALVIRHPEQGSVAEFARATNLPVINgGDGPGEHPSQALLDLYTIQrEFSRLGKIvdgahiALV 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    151 GD---GNNVaHSLMQASA-KMGVDCRIATPEGMEPDEEIQDRVS--DANVTVTNDPYEAVDGATAVYGDVFVSmgEEEQR 224
Cdd:PRK11891 248 GDlkyGRTV-HSLVKLLAlYRGLKFTLVSPPTLEMPAYIVEQISrnGHVIEQTDDLAAGLRGADVVYATRIQK--ERFAD 324

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550341    225 EEKLAEFDGFQIDQDLMDAA-RDDAIFMHCLPAHR---GEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLV 293
Cdd:PRK11891 325 ESFEGYTPDFQINQALVDAVcKPDTLIMHPLPRDSrpgANDLSTDLNRDPRLAIFRQTDNGIPVRMAIFAVLL 397
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 2-288 3.18e-27

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 108.28  E-value: 3.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      2 EHLVDINDVESEEIEQLLDLAASMKenP----GEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGH-----GiffeM 72
Cdd:PRK08192   6 SHILSVNQLDRDAIQRIFNVADRME--PyalrEKRTRVLEGAILGNLFFEPSTRTRVSFGCAFNLLGGHvrettG----M 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     73 GSSQLSRGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGlTDFL--HPCQALTDMFTMQEKDR-----LD 145
Cdd:PRK08192  80 ASSSLSKGESLYDTARVLSTYSDVIAMRHPDAGSVKEFAEGSRVPVING-GDGSneHPTQALLDLFTIQKELAhagrgID 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    146 TL--AFVGD---GNNVaHSLMQ-ASAKMGVDCRIATPEGMEPDEEIQDRVSDAN--VTVTNDPYEAVDGATAVYgdvfvS 217
Cdd:PRK08192 159 GMhiAMVGDlkfGRTV-HSLSRlLCMYKNVSFTLVSPKELAMPDYVISDIENAGhkITITDQLEGNLDKADILY-----L 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550341    218 MGEEEQREEKLAEFD----GFQIDQDLMDA-ARDDAIFMHCLPA-HRGE--EVTAEVADGPQSVIFDQAENRMHVQKAI 288
Cdd:PRK08192 233 TRIQEERFPSQEEANkyrgKFRLNQSIYTQhCKSNTVIMHPLPRdSRAQanELDNDLNSHPNLAIFRQADNGLLIRMAL 311
pyrB PRK13814
aspartate carbamoyltransferase;
3-289 9.56e-22

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 92.86  E-value: 9.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341      3 HLVDINDVESEEIEQLLDLAASMKENPGEFSGVMDN---KSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSR 79
Cdd:PRK13814   7 HLLNMRSLTRDHIEKLIQRANYFLTQGMEKNSVFETlkgHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     80 GEPISDVS---QVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTM-QEKDRLDTL--AFVGD- 152
Cdd:PRK13814  87 GETLFDTIktlEAMGVYFFIVRHSENETPEQIAKQLSSGVVINAGDGNHQHPSQALIDLMTIkQHKPHWNKLcvTIIGDi 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    153 -GNNVAHSLMQASAKMGV-DCRIATPEGMEPDEeiqdrvsdanvtVTNDPYEAVD--GATAVYGDVFVSMGEEEQREEKL 228
Cdd:PRK13814 167 rHSRVANSLMDGLVTMGVpEIRLVGPSSLLPDK------------VGNDSIKKFTelKPSLLNSDVIVTLRLQKERHDNS 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550341    229 AEFDGFQ----IDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIV 289
Cdd:PRK13814 235 VDIDAFRgsfrLTPEKLYSAKPDAIVMHPGPVNREVEINSDVADNQQSVILQQVRNGVAMRMAVL 299
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 13-268 1.29e-13

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 70.54  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     13 EEIEQLLDLAASMK----ENPGefSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRGEPISDVSQ 88
Cdd:PRK07200  32 DELKAVLDVADALRalreENIS--TKVFNSGLGISVFRDNSTRTRFSYASACNLLGLEVQDLDEGKSQIAHGETVRETAN 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341     89 VMSRYEDAIMAR--LF---EHDEMMELAENADV-----------PVVNGLTDFLHPCQALTDMFTMQE----------KD 142
Cdd:PRK07200 110 MISFMADVIGIRddMYigkGNAYMREVGAAVDDgykqgvlpqrpTLVNLQCDIDHPTQSMADLLHLIEhfgglenlkgKK 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    143 RLDTLAF---VGDGNNVAHSLMQASAKMGVDCRIATPEGMEPDEEIQD------RVSDANVTVTNDPYEAVDGATAVYGD 213
Cdd:PRK07200 190 IAMTWAYspsYGKPLSVPQGIIGLMTRFGMDVTLAHPEGYDLMPEVVEvakknaKASGGSFRQVNSMEEAFKDADIVYPK 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550341    214 VFVSMGEEEQREEKLAEFDGFQID-------------------QDLMDAARD-DAIFMHCLPAH------RGEEVTAEVA 267
Cdd:PRK07200 270 SWAPYKVMEERTELYRAGDHEGIKalekellaqnaqhkdwhctEEMMKLTKDgKALYMHCLPADisgvscKEGEVTESVF 349


                 .
gi 550341    268 D 268
Cdd:PRK07200 350 D 350
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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