|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
3-466 |
0e+00 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 639.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 3 MDNRLPPKKVPGFCSFRYGLSFLVHCCNVIITAQRACLNLTMVVMVNSTDPHGLPNTSTKKLLDNIKNPMYNWSPDIQGI 82
Cdd:TIGR00894 1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKNPNFKWSGALQGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 83 ILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVKWA 162
Cdd:TIGR00894 81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 163 PPLERGRLTSMSTSGFLLGPFIVLLVTGVICES-LGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCISISEKEYITSS 241
Cdd:TIGR00894 161 PPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 242 LVQQVSSSRQSLPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQL 321
Cdd:TIGR00894 241 LQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 322 SDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPRYFGFIKAC 401
Cdd:TIGR00894 321 ADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGI 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 450532 402 STLTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAINVTGLIFYLIVATAEIQDWAKEKQHTR 466
Cdd:TIGR00894 401 TGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
23-451 |
1.11e-149 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 431.66 E-value: 1.11e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 23 SFLVHCCNVIITAQRACLNLTMVVMVNSTDPHGLPNTSTKKLLDNIKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFS 102
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 103 GIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGP 182
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 183 FIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLfyddpkdhpcisisekeyitsslvqqvsssrqslpikailkSL 262
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL-----------------------------------------VL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 263 PVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTA 342
Cdd:cd17318 200 PVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 343 AGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLILK 422
Cdd:cd17318 280 IGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVK 359
|
410 420 430
....*....|....*....|....*....|
gi 450532 423 QD-PESAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:cd17318 360 NDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
32-451 |
3.39e-80 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 254.32 E-value: 3.39e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 32 IITAQRACLNLTMVVMVNSTDPHGLPNTS--------TKKLLDNIKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFSG 103
Cdd:cd17381 11 VVYALRVNLSVALVDMVNSNSTLPSNNSSnacpehssSPSVEHNETGKKYDWDAETQGWILGSFFYGYIITQIPGGYLAS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 104 IYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPF 183
Cdd:cd17381 91 KIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 184 IVLLVTGVICESLGWPMVFYIFGACGCavclLWFVLFyddpkdhpcisisekeyitsslvqqvsssrqslpikaILKSLP 263
Cdd:cd17381 171 VSLPLSGLICYYLDWTYVFYIFGAVGL----LWFFLW-------------------------------------IWLVMP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 264 VWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAA 343
Cdd:cd17381 210 LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTVCVRKIFTLI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 344 GFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPRY----FGFIKACSTLTGMIGGLIASTLTgl 419
Cdd:cd17381 290 GMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYagilLGITNTFATIPGMVGPVIAKSLT-- 367
|
410 420 430
....*....|....*....|....*....|..
gi 450532 420 ilKQDPESAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:cd17381 368 --HNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
58-451 |
3.35e-57 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 193.71 E-value: 3.35e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 58 NTSTKKLLDNIKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVV 137
Cdd:cd17382 29 FTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 138 VCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCavclLWF 217
Cdd:cd17382 109 FVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGI----IWY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 218 VLFyddpkdhpcisisekeyitsslvqqvsssrqslpikaILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNI 297
Cdd:cd17382 185 MFW-------------------------------------MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 298 KENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPYLSSTFYSIViFLILAGATGS 377
Cdd:cd17382 228 SKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFGMEATFLLVVAFSHSPTVAIS-FLVLAVGFSG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 450532 378 FCLGGVFINGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:cd17382 307 FAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
73-451 |
6.13e-54 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 184.68 E-value: 6.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQGIVAT 152
Cdd:cd17380 29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFyddpkdhpcisi 232
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 233 sekeyitsslvqqvsssrqslpikailksLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLhVNIKENGFLSSLPYLFAW 312
Cdd:cd17380 177 -----------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 313 ICGNLAGQLSDFFLTRNIlSVIAVRKLFTAAGFLLPAIFGVCLPYLSStFYSIVIFLILAGATGSFCLGGVFINGLDIAP 392
Cdd:cd17380 227 PSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHTDS-FSLALLCMSVALGLSAFSSSGVLVNHQDIAP 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 450532 393 RY----FGFIKACSTLTGMIGGLiastLTGLILKQdpESAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:cd17380 305 NYagivFGISNTAGTIPGIVGVY----LTGYILEA--TGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
74-450 |
5.56e-27 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 111.12 E-value: 5.56e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 74 NWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVVVCRAVQGAAQGIVATA 153
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT--GFATSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 154 QFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDdpkdhpcisis 233
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 234 ekeyitsslvqqvsssrqslpikailkslpVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWI 313
Cdd:cd17319 181 ------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 314 CGNLAGQLSDFFLTRNilsviavRKLFTAAGFLLpAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPR 393
Cdd:cd17319 231 GMILGGRLSDRLLRGA-------RRLVIIIGLLL-AAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 450532 394 -----YFGFIKACstltGMIGGLIASTLTGLILkqDPESAWFKTFILMAAINVTGLIFYLIV 450
Cdd:cd17319 303 eaaatAGGLINSG----GNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
73-451 |
2.96e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 109.19 E-value: 2.96e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVVVCRAVQGAAQGIVAT 152
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF--GFATSFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGAcgcaVCLLWFVLfyddpkdhpcisi 232
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL----PGLLLALL------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 233 sekeyitsslvqqvsssrqslpikailkslPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAW 312
Cdd:COG2271 181 ------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 313 ICGNLAGQLSDFFLTRnilsviavRKLFTAAGFLLPAIFGVCLPYLSSTfYSIVIFLILAGATGSFCLGGVFINGLDIAP 392
Cdd:COG2271 231 VGSLLGGWLSDRLGRR--------RKLVLAIGLLLAALALLLLALLPSP-ALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 393 -RYFGFIKACSTLTGMIGGLIASTLTGLILKQdpeSAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:COG2271 302 kKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
73-409 |
1.15e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.95 E-value: 1.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVVVCRAVQGAAQGIVAT 152
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL--LFASSLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFvlFYDDPKDHPCISI 232
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL--LPRPPPESKRPKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 233 SEKEYITSSlvqqvsssrqsLPIKAILKSLPVWAIsIGSFTFFWSHNIMTLYTPMFINSmLHVNIKENGFLSSLPYLFAW 312
Cdd:pfam07690 183 AEEARLSLI-----------VAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 313 ICGNLAGQLSDFFLTRnilsviavRKLFTAAGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAP 392
Cdd:pfam07690 250 IGRLLLGRLSDRLGRR--------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|..
gi 450532 393 -----RYFGFIKACSTLTGMIG 409
Cdd:pfam07690 322 keergTASGLYNTAGSLGGALG 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
73-450 |
6.99e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 91.10 E-value: 6.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSsvlsllIPPAAGIGVA----WVVVCRAVQGAAQG 148
Cdd:COG2223 35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL------GIGLLLLALAvsywLLLLLGLLLGIGGG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 149 IVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHP 228
Cdd:COG2223 109 GSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 229 cisisekeyitsslvqqvSSSRQSL-PIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLP 307
Cdd:COG2223 189 ------------------AAAKASLrDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 308 YLFAWICGNLAGQLSDFFLTRNILSVIavrklftaagFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFing 387
Cdd:COG2223 251 ALLGALGRPLGGWLSDRIGGRRVLLIV----------FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF--- 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 450532 388 lDIAPRYFGfIKACSTLTGMI------GGLIASTLTGLILkqDPESAWFKTFILMAAINVTGLIFYLIV 450
Cdd:COG2223 318 -ALVPDIFP-TKNAGAVYGLVgaagglGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
73-448 |
1.76e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.79 E-value: 1.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVVVCRAVQGAAQGIVAT 152
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF--AFAPSFWLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESL--GWPMVFYIFGAcgcaVCLLWFVLFYDDPKDHPCI 230
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA----LALLAAILLLLVVPDPPES 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 231 SISEKEYITSSlvqqvsssRQSLPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLF 310
Cdd:cd06174 180 ARAKNEEASSK--------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 311 AWICGNLAGQLSDFFLTRNILSVIavrklftaaGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDI 390
Cdd:cd06174 252 GALGSLLLGLLSDRLIGRKPLLLI---------GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 450532 391 APRYFGFIKACSTLTGMIGGLIASTLTGLILKQDPesAWFKTFILMAAINVTGLIFYL 448
Cdd:cd06174 323 PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF--GLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
73-392 |
1.95e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.40 E-value: 1.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGvaWVVVCRAVQGAAQGIVAT 152
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW--LLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLL-WFVLfyddPKDHPcis 231
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLlLRLL----PESRP--- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 232 isekeyitsslvqqVSSSRQSLPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFA 311
Cdd:COG2814 191 --------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 312 WICGNLAGQLSDFFLTRNILSVIAvrkLFTAAGFLLPAifgvclpyLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIA 391
Cdd:COG2814 257 VLGALLAGRLADRFGRRRLLLIGL---LLLALGLLLLA--------LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
.
gi 450532 392 P 392
Cdd:COG2814 326 P 326
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
81-449 |
7.28e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 78.77 E-value: 7.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 81 GIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAgiGVAWVVVCRAVQGAAQGIVATAQFEIYVK 160
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT--SYWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVclLWFVLFYDDPKDHPCISISEKEyits 240
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLA--LVLALLLLPEPRPPPNKRAVSA---- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 241 slvqqvssSRQSLPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQ 320
Cdd:cd17325 186 --------ARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 321 LSDFFltrnilsviaVRKLFTAAGFLLPAIFGVCLPyLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPR-----YF 395
Cdd:cd17325 258 LSDRI----------GRKPLILIGLLLSAVALLLLP-LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPegrgtAM 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 450532 396 GFIKACSTLTGMIGGLIASTLTGLIlkqdpesAWFKTFILMAAINVTGLIFYLI 449
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDAF-------GFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
81-439 |
1.74e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 68.73 E-value: 1.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 81 GIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIgvAWVVVCRAVQGAAQGIVATAQFEIYVK 160
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--ALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPcisisekeyits 240
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 241 slvqqvSSSRQSLPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQ 320
Cdd:cd17324 183 ------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 321 LSDFFLTRNILsviavrklftaAGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPRYFGFIKA 400
Cdd:cd17324 257 LADRGGRRALL-----------IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASS 325
|
330 340 350
....*....|....*....|....*....|....*....
gi 450532 401 CSTLTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAI 439
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
81-446 |
1.88e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 65.34 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 81 GIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVK 160
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM--ALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGAcGCAVCLLWFVLFYDDPKDHPCISISEKEYITS 240
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGL-VSILAAVLFWLFYREPPAASAATESASTLLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 241 slvqqvsssrqslpIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLpylfAWICGNLA-- 318
Cdd:cd17475 191 --------------LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAV----AQLGGALGri 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 319 --GQLSDFFLTRNILSVIAVRKLFTAAGFLLpaifgVCLPYLSSTFYSIVIFLILAGAtgsFCLG--GVFINGL-DIAPR 393
Cdd:cd17475 253 glGRVSDRVFGGRRRPVLVITAAIAAAALLV-----LSLLSPGTPLWLLVLLLILLGL---FAIGwnGLYLTLVaESAGP 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 450532 394 YF-GFIKACSTLTGMIGGLIASTLTGLILKQ--DPESAWfktFILMAAINVTGLIF 446
Cdd:cd17475 325 EQaGTALGLANTINFIGIAIGPPLFGLLVDAthSYAPAW---LALALLLVLAALLL 377
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
81-422 |
7.86e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 63.55 E-value: 7.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 81 GIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSvlsllippAAGIGVAWV------VVCRAVQGAAQGIVATAQ 154
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCA--------IVNLFFGFStslwvmAALWALNGIFQGMGWPPC 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 155 FEIYVKWAPPLERGRLTSM-STSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDhPCISIS 233
Cdd:TIGR00881 105 GRTVTKWFSRSERGTWVSFwNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 234 EKEYITSSLVQQVSSSRQSLPIKA----ILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYL 309
Cdd:TIGR00881 184 EEMPNEEPDGDAEKKEEELTKKQIflqyVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYEL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 310 FAWICGNLAGQLSDFFLTRNILSViavrKLFTAAGFLLPAIFGVCLPylSSTFYSIVIFLILAGatgsfCLGGVFINGLD 389
Cdd:TIGR00881 264 GGLVGTLLAGWLSDKLFNGRRGPL----AVFFMALIIVSLLVYWLNP--AANPLMDLICLFALG-----FLVYGPQMLIG 332
|
330 340 350
....*....|....*....|....*....|....*....
gi 450532 390 IAPRYFGFIKACSTLTGM------IGGLIASTLTGLILK 422
Cdd:TIGR00881 333 VIASELAPKKAAGTAAGFvgffayLGGILAGLPLGYLAD 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
137-450 |
2.47e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 55.74 E-value: 2.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 137 VVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLW 216
Cdd:cd17312 95 AVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIIL 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 217 FVLFYDDPKdhpcisisekeyitsslvqqvsssrqslpikailkslPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVN 296
Cdd:cd17312 175 FFFLRDSPP-------------------------------------YVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYS 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 297 IKENGFLSSLPYLFAWICGNLAGQLSDFFL--TRNILSVIavrklftaagFLLPAIFGVCLPYLS-STFYSIVIFLILAg 373
Cdd:cd17312 218 LIDAGWFSSLYEVGGIAGTILAGLLSDKLFggRRAPIAVI----------YMLLMTLSLALFWFFpHNKLLSIVLLFLI- 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 374 atgsfclgGVFINGLD-----IAPRYFGFIKACSTLTGMIGGL--IASTLTGLIL-KQDPESAWFKTFILMAAINVTGLI 445
Cdd:cd17312 287 --------GFFVGGPInliggAAAQDIGRKEAAGTATGFVGLFgyLGASLAGLPLgYIIDHYGWSTVFYFLISAALLSVL 358
|
....*
gi 450532 446 FYLIV 450
Cdd:cd17312 359 LLLSL 363
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
76-219 |
5.26e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.27 E-value: 5.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 76 SPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVVVCRAVQGAAQGIVATAQF 155
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC--GLAPSPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 450532 156 EIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVL 219
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
166-421 |
9.49e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 9.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 166 ERGRLTSMSTSGFLLGPFIVLLVTGVI------CESLGWPMVFYIFGACGcAVCLLWFVLFYDDPKDHPCISISEKEYit 239
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLG-LLAFLLTFFGTKERPVPEEEKVSLKES-- 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 240 sslvqqvsssrqslpIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAG 319
Cdd:COG2211 221 ---------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 320 QLSDFFLTRNILSVIAvrkLFTAAGFLLPAIFGvclpylSSTFYSIVIFLILAGatgsFCLGGVFINGL----DIAP--- 392
Cdd:COG2211 286 RLAKRFGKKKAFIIGL---LLAALGLLLLFFLG------PGNLWLLLVLAALAG----IGLGAILVLPWamlaDVVDyde 352
|
250 260 270
....*....|....*....|....*....|....
gi 450532 393 -----RYFGFIKACSTLTGMIGGLIASTLTGLIL 421
Cdd:COG2211 353 wktgrRREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
73-451 |
1.66e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 46.85 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILS--STSYGviIIQVPVGYFSGIYSTKKM--IGFALCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQG 148
Cdd:cd17345 33 YGLSKTEIGLIGSalSIAYG--LSKFVMGNLSDRSNPKRFlaIGLILSAIINILIGFVPSATSSVGLMFILLFLNGWFQG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 149 IVATAQFEIYVKWAPPLERGRLTSM-STS----GFLLGPFIVLLVTGVICESLGWpmVFYIFGACGCAVCLLWFVLFYDD 223
Cdd:cd17345 111 MGWPPSGRTMVHWFSKKERGTWTSIwNIShnvgGGLVGPLAGLGLAIFGDGWWRG--AFIFPAIIAIIVAVIVLFLGKDT 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 224 P------------KDHPCISISEKEYitsslvqQVSSSRQSLpIKAILKSLPVWAISI-GSFTFFWSHNIMTlYTPMFIN 290
Cdd:cd17345 189 PeseglppieeykGDYPEEADGEEEE-------QELSAWEIF-VKYVLKNKLLWYIAIaNVFVYLVRYGILD-WAPTYLS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 291 SMLHVNIKENGFLSSLpYLFAWICGNL-AGQLSDfFLTRNilsviavRKLFTAAGFLLPAIFGVCLPYLSSTFYSIVIFL 369
Cdd:cd17345 260 EVKGFSKAQAMWAFSL-FEWAAIPGTLlAGWLSD-KLFKG-------RRAPTGIIFMILVIVALIVYWLAPNVLVDLIAL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 370 ILAGAtgsFCLGGVFINGL---DIAPRyfgfiKACSTLTGM-------IGGLIASTLTGLILKQdpeSAWFKTFILMAAI 439
Cdd:cd17345 331 IALGF---LIYGPVMLIGLqalELVPK-----KAAGTAAGLtglfgylGGSVLATALIGIIVDH---FGWNGGFIVLLAS 399
|
410
....*....|..
gi 450532 440 NVTGLIFYLIVA 451
Cdd:cd17345 400 CILAIIFLALVA 411
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
142-446 |
3.36e-05 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 46.17 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 142 VQGAAQGIVATAQFEIYVKWAPPLERGRL-----TSMSTSGfLLGPFIvllvTGVICESLGWPMVFYIFGACGCAVCLLW 216
Cdd:cd17343 100 LNGLAQGLGWPPCAKILRKWFSPSQFGTWwsvlsTSMNLAG-SLGPIL----ATLLALSYGWRSTLSISGTVAVVMSVVC 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 217 FVLFYDDPKDHPCISISEKEyitsSLVQQVSSSRQSLPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMF-INSMLHV 295
Cdd:cd17343 175 LLFIKNEPSDVGLNNIEEEE----SKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFlIQDKGQS 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 296 NIKENGFLSSLPyLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAAGFllpaIFGVCL----------PYLSSTFYSI 365
Cdd:cd17343 251 ALTGSSFMSSLE-VGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVF----MAGLTVslhlfrvhitSDSSELFILL 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 366 VIFLILAGATGSFCLGGVFINglDIAPRYF-GFIKACSTLTGMIGGLIASTLTGLILKQdpeSAWFKTFILM---AAINV 441
Cdd:cd17343 326 LGFLIGFSLYGPIAIFGVIAN--ESAPSHLcGTSHAIVALAANVGGVLAGLPFSYIAKH---YDWRTAFLLLeilCAITV 400
|
....*
gi 450532 442 TGLIF 446
Cdd:cd17343 401 VILFL 405
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
73-217 |
7.96e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 7.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILSSTSYGVIIIQVPVGYFSGI-YSTKKMIGFALCLSSVLSLLIPPAAGIgvAWVVVCRAVQGAAQGIVA 151
Cdd:cd17474 229 YGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSL--ALLLIAIVLFGLGLGLNL 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 450532 152 TAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWF 217
Cdd:cd17474 307 PLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
132-457 |
1.83e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 132 GVAWVVVCRAVQGAAQGIVATAqFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCA 211
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVL-LPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 212 VCLLWFVLFYDDPKDHPcisisekeyitsslvqqvsSSRQSLPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINS 291
Cdd:COG2807 184 ALLLWLPLLRRRPAAAA-------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 292 mLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVrkLFTAAGFLLPAIFGVCLPYLsstfysiviFLIL 371
Cdd:COG2807 245 -AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG--LLGLAGLLGLLLAPGSLPWL---------WAVL 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 372 AGatgsFCLGGVFINGLDIAPRYFGFIKACSTLTGM---IGGLIAST---LTGLIlkQDPESAWFKTFILMAAINVTGLI 445
Cdd:COG2807 313 LG----LGQGGLFPLALTLIGLRARTPAEAAALSGMaqsVGYLLAALgplLVGAL--HDATGSWTAALLLLAALAVLMLV 386
|
330
....*....|..
gi 450532 446 FYLIVATAEIQD 457
Cdd:COG2807 387 AGLLAGRPYVED 398
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
76-448 |
2.49e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.97 E-value: 2.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 76 SPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIgvAWVVVCRAVQGAAQGIVATAQF 155
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV--ALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 156 EIYVKWAPPLERGRLTSM----STSGFLLGPFIVLLVTGVicesLGWPMVFYIFGACGCAVCLLWFVLfyddpKDHPCIS 231
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYyglaTTLAMALGPALGLFLYQH----LGFAVLFIVAAVLALLALLLVFLV-----KDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 232 ISEKEYITsslvqqvsssrqSLPIKAILKSlpVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIkenGFLSSLPYLFA 311
Cdd:cd17489 178 AEEAEAGT------------RAFRRLVEKK--VLPPALILFLASIAYGAISTFLPLYAAERGISNA---GLFFTVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 312 WICGNLAGQLSDFFltrnilsviaVRKLFTAAGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSF--CLGGVFINGLD 389
Cdd:cd17489 241 LLSRPFSGKLSDRK----------GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLfpALQALAVDLVP 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 450532 390 IAPR------YFGFIKACSTLTGMIGGLIASTLtglilkqdpesAWFKTFILMAAINVTGLIFYL 448
Cdd:cd17489 311 PHRRgaangtFFIFFDLGIGLGGLLLGLVAELF-----------GYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
132-453 |
2.70e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.93 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 132 GVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCA 211
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 212 VCLLwfvlfyddpkdhpcisisekeyitsslvqqvsssrqslpikailkSLPVWAISIGSFTFFWSHNIMTLYTPMFINS 291
Cdd:cd17321 163 ALLL---------------------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 292 MLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAvrkLFTAAGFLLPAIFGVclpylSSTFYSIVIFLIL 371
Cdd:cd17321 198 VLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL---LLTAVGLLLLALLGA-----DSSVWLLLPGLVL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 372 AGATGSFCLGGVFINGLDIAPRYF-----GFIKACSTLTGMIG-GLIASTLTGLILKQDPESAWFKTFILMAAINVTGLI 445
Cdd:cd17321 270 LGLGLGLFATPLTNAALSSVPKEKagaasGILNTARQLGGALGvALLGALLTAGLSANLGDSGVAALLSAAAAAFAAGFH 349
|
....*...
gi 450532 446 FYLIVATA 453
Cdd:cd17321 350 LAFLVAAA 357
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
135-450 |
3.89e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.55 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 135 WVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGF----LLGPFIvllvTGVICESLGWPMVFYIfgacgc 210
Cdd:cd17502 85 MLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFgiasVAGPLI----GGAFTDHLSWRWCFYI------ 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 211 avcllwfvlfyddpkdhpcisisekeyitsslvqqvsssrqSLPIKAI-LKSLP-VWAISIGSFTFFWSHNIMTLYTPMF 288
Cdd:cd17502 155 -----------------------------------------NLPIGGLaLALLRtILLSSIFGFLFGGALFGLIYYLPLY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 289 INSMLHVNIKENGFLsSLPYLFAWICGNLAGQLsdffltrnILSVIAVRKLFTAAGFLLPAIFGVCLPYLSSTfySIVIF 368
Cdd:cd17502 194 FQLVLGDSATKSGVR-LLPLIIGLVIGSIISGA--------LISKTGRYKPLIVIGTILMSVGAGLLTTLTLD--TSKWL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 369 LILAGATGSFCLGGVFINGL-----DIAPRYFGFIKACSTLTGMIGGLIASTLTglilkqdpesawfKTFILMAAINVTG 443
Cdd:cd17502 263 LIGYLILLGLGLGIGFQQPLvavqnAVPPADVGVATATNTFFRSLGGTLGVAIT-------------DVFLVALALAALA 329
|
....*..
gi 450532 444 LIFYLIV 450
Cdd:cd17502 330 FLLSLFL 336
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
73-439 |
4.15e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 4.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 73 YNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVawVVVCRAVQGAAQGIVAT 152
Cdd:cd17333 26 FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL--FVVLMFLAGLGAGILDT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 153 AQfEIYVKWAPPLERGRLTSMSTSGFLLGPFIV-LLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCis 231
Cdd:cd17333 104 GA-NTFVGALFEESSATRLNVLHGFFGLGALIGpLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARN-- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 232 isekeyitsslvQQVSSSRQSLPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSlpylFA 311
Cdd:cd17333 181 ------------PQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS----GF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 312 WICgnlagqlsdFFLTRNILSVIAVRKLFTAagFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIA 391
Cdd:cd17333 245 WVG---------ITIGRLLGGPISRRIKPHT--LLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 450532 392 PRYFGFIKACST----LTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAI 439
Cdd:cd17333 314 ISNLPYAKGKGTsvllAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
134-204 |
1.03e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.41 E-value: 1.03e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 450532 134 AWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYI 204
Cdd:cd17503 85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI 155
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
81-420 |
1.11e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 81 GIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVVVCRAVQGAAQGIVATAQfEIYVK 160
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF--ALAPSYPLLLLALFLLGLGLGLLDVAA-NPYVA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 161 WAPPLERGRLTSMSTS----GFLLGPFIVLLVTGVIcESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCISISEKE 236
Cdd:COG0738 123 ALGPETAASRLNLLHAffslGALLGPLLGGLLILLG-LSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 237 yitsslvqqvsssrqslPIKAILKSLPVWAISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLpYLFAWICGN 316
Cdd:COG0738 202 -----------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL-FWGGMTIGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 317 LAGqlsDFFLTRnilsvIAVRKLFTAAGFLlpAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPRYFG 396
Cdd:COG0738 264 FLG---GFLLKR-----FGPVRLLRLSALL--AAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTA 333
|
330 340
....*....|....*....|....
gi 450532 397 FIKACSTLTGMIGGLIASTLTGLI 420
Cdd:COG0738 334 AAVSAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
81-219 |
1.14e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 81 GIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVK 160
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL--GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 450532 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVL 219
Cdd:cd06173 325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
267-452 |
1.29e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 267 ISIGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSViavrklftaagFL 346
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI-----------GL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 347 LPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAP-----RYFGFIKACSTLTGMIGGLIASTLTGLIl 421
Cdd:pfam07690 70 LLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPpeergRALGLVSAGFGLGAALGPLLGGLLASLF- 148
|
170 180 190
....*....|....*....|....*....|.
gi 450532 422 kqdpesAWFKTFILMAAINVTGLIFYLIVAT 452
Cdd:pfam07690 149 ------GWRAAFLILAILSLLAAVLLLLPRP 173
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
135-227 |
1.75e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 40.83 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 135 WVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCL 214
Cdd:TIGR00711 92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVV 171
|
90
....*....|....
gi 450532 215 L-WFVLFYDDPKDH 227
Cdd:TIGR00711 172 VaFFILPRDKPAAS 185
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
81-219 |
2.01e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.40 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 81 GIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFalCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVK 160
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLV--GLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGA-CGCAVCLLWFVL 219
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAIlALAAFILLAFLL 138
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-221 |
2.19e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.25 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 72 MYNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIgvAWVVVCRAVQGAAQGIVA 151
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF--WLLLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 450532 152 TAQFEIYVKWAPPLERGR----LTSMSTSGFLLGPfivlLVTGVICESLGWPMVFYiFGACGCAVCLLWFVLFY 221
Cdd:cd17325 307 PATLALLADIVPPEGRGTamglFNTAFSLGMVLGP----LLGGFLYDAFGFATPFL-AAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
260-446 |
5.15e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 5.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 260 KSLPVWAISIGSFTFFWSHNIMTLYTPMFINSmLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVrkL 339
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL--L 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 340 FTAAGFLLPaifgvclpyLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAP-----RYFGFIKACSTLTGMIGGLIAS 414
Cdd:COG2814 85 FALGSLLCA---------LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPperrgRALGLLGAGLGLGPALGPLLGG 155
|
170 180 190
....*....|....*....|....*....|..
gi 450532 415 TLTGLIlkqdpesAWFKTFILMAAINVTGLIF 446
Cdd:COG2814 156 LLADLF-------GWRWVFLVNAVLALLALLL 180
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
264-453 |
8.66e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 8.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 264 VWAISIGSFTFFWSHNIMTLYTPMFINSmLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAvrkLFTAA 343
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL---LLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 344 GFLLPAifgvclpyLSSTFYSIVIFLILAGATGSFCLGGVF-INGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLILK 422
Cdd:COG2271 88 ATLLFG--------FATSFWQLLLLRFLLGLGEAGFFPAALkLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190
....*....|....*....|....*....|.
gi 450532 423 QDpesAWFKTFILMAAINVTGLIFYLIVATA 453
Cdd:COG2271 160 AF---GWRAAFLILGLPGLLLALLRFWLLAL 187
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
135-374 |
9.64e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 9.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 135 WVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICEsLGWPMVFYIFGACGCAVCL 214
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLIL 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 215 LWFVLFYDDPKDHPCISISEKEyitsslvqqvsssRQSLPIKAIlksLPVWAISIGSFTFFWshnIMTLYTPMFINSMLH 294
Cdd:cd17473 169 VLLFLPEPARKSKSAASPGAAT-------------AAALPWKRV---LPIYFLAFLAMLLFY---VIPIQLPFLLQERGG 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 450532 295 VNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVrklFTAAGFLLPAifgvclpyLSSTFYSIVIFLILAGA 374
Cdd:cd17473 230 GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA---LMALGFLLLA--------LASGLWVVLLGAILAGL 298
|
|
| |
