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Conserved domains on  [gi|12881|emb|CAA39491|]
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NADH dehydrogenase subunit 4 (mitochondrion) [Strigomonas oncopelti]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05846 super family cl35392
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 169-391 3.12e-17

NADH:ubiquinone oxidoreductase subunit M; Reviewed


The actual alignment was detected with superfamily member PRK05846:

Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 83.71  E-value: 3.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     169 SLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVM 248
Cdd:PRK05846 206 PPGVQYWLFLAFFIAFAVKMPMFPLHTWLPDAHVQAPTAGSVLLAGILLKMGAYGLLRFSLPLFPDASHEFAPIIITLGV 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     249 LGLTFLSISLLFQSDYKKIIANWSVIHtgMGLILLWHNDLLFIGI--LFFCNLSHIISSAFMFIMVGYMYDNFGLRifli 326
Cdd:PRK05846 286 IAIIYGALVALAQTDIKKLIAYSSISH--MGFVTLGIFAGNQLGIqgAIFQMISHGLSSAALFLLVGVLYDRLHTR---- 359

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     327 MTSFFG-----VSIWSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIIcfyVIVLSVFVSSIYI 391
Cdd:PRK05846 360 DIADYGglakvMPVLAAFFLFFAMASLGLPGTSGFVGEFLILLGSFQVNPVIAF---IATTGLILAAVYS 426
 
Name Accession Description Interval E-value
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 169-391 3.12e-17

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 83.71  E-value: 3.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     169 SLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVM 248
Cdd:PRK05846 206 PPGVQYWLFLAFFIAFAVKMPMFPLHTWLPDAHVQAPTAGSVLLAGILLKMGAYGLLRFSLPLFPDASHEFAPIIITLGV 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     249 LGLTFLSISLLFQSDYKKIIANWSVIHtgMGLILLWHNDLLFIGI--LFFCNLSHIISSAFMFIMVGYMYDNFGLRifli 326
Cdd:PRK05846 286 IAIIYGALVALAQTDIKKLIAYSSISH--MGFVTLGIFAGNQLGIqgAIFQMISHGLSSAALFLLVGVLYDRLHTR---- 359

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     327 MTSFFG-----VSIWSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIIcfyVIVLSVFVSSIYI 391
Cdd:PRK05846 360 DIADYGglakvMPVLAAFFLFFAMASLGLPGTSGFVGEFLILLGSFQVNPVIAF---IATTGLILAAVYS 426
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 169-391 6.49e-17

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 82.44  E-value: 6.49e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881    169 SLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVM 248
Cdd:COG1008 204 PLTAQLLLFLAFFIAFAVKVPMFPFHTWLPDAHVEAPTAGSVLLAGVLLKMGGYGLLRFALPLFPEASAYFAPLLAALGV 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881    249 LGLTFLSISLLFQSDYKKIIANWSVIHtgMGLILL---WHNDLLFIGILFFcNLSHIISSAFMFIMVGYMYDNFGLRifl 325
Cdd:COG1008 284 IGIIYGALVALAQTDLKRLIAYSSVSH--MGFVLLgifALNPLGLQGAVLQ-MVSHGLITAALFLLVGVLYDRTHTR--- 357

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881    326 IMTSFFGVS----IWSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIIcfyVIVLSVFVSSIYI 391
Cdd:COG1008 358 DIADLGGLAkrmpVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAI---LAALGLILTAAYL 424
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 176-383 1.23e-15

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 78.83  E-value: 1.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      176 IWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVMLGLTFLS 255
Cdd:TIGR01972 205 LFLAFFIAFAVKVPLFPLHTWLPDAHVEAPTAGSVILAGVLLKMGTYGFLRFNLPLFPDASLYFAPVLAALGVIAIIYGA 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      256 ISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYMYDNFGLRIFLIMTSFFGVSI 335
Cdd:TIGR01972 285 LIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYERAHTRDIAKYGGLANKMP 364

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 12881      336 WSSLFLGMFLF-NIDFPFMLLFYIDIFILYGLISLSFIY-IICFYVIVLS 383
Cdd:TIGR01972 365 VLAAFFMLFAMaSLGLPGTSGFVGEFLILLGSFKVNPVVaFLAALGIVLA 414
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 178-380 2.11e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 61.18  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      178 ILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLaFNQVSIWFLGVIDSMVMLGLTFLSIS 257
Cdd:pfam00361  86 LLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAATLVKAGGYGLIRRSLL-YLPSSPFIQQILLILAIISMLLGSLA 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      258 LLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYM-YDNFGLRIFLIMTSFF-GVSI 335
Cdd:pfam00361 165 ALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAGSViYRRVHTRNIRDYGGLAkTMPI 244

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 12881      336 WSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIICFYVI 380
Cdd:pfam00361 245 LALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVV 289
 
Name Accession Description Interval E-value
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 169-391 3.12e-17

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 83.71  E-value: 3.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     169 SLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVM 248
Cdd:PRK05846 206 PPGVQYWLFLAFFIAFAVKMPMFPLHTWLPDAHVQAPTAGSVLLAGILLKMGAYGLLRFSLPLFPDASHEFAPIIITLGV 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     249 LGLTFLSISLLFQSDYKKIIANWSVIHtgMGLILLWHNDLLFIGI--LFFCNLSHIISSAFMFIMVGYMYDNFGLRifli 326
Cdd:PRK05846 286 IAIIYGALVALAQTDIKKLIAYSSISH--MGFVTLGIFAGNQLGIqgAIFQMISHGLSSAALFLLVGVLYDRLHTR---- 359

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     327 MTSFFG-----VSIWSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIIcfyVIVLSVFVSSIYI 391
Cdd:PRK05846 360 DIADYGglakvMPVLAAFFLFFAMASLGLPGTSGFVGEFLILLGSFQVNPVIAF---IATTGLILAAVYS 426
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 169-391 6.49e-17

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 82.44  E-value: 6.49e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881    169 SLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVM 248
Cdd:COG1008 204 PLTAQLLLFLAFFIAFAVKVPMFPFHTWLPDAHVEAPTAGSVLLAGVLLKMGGYGLLRFALPLFPEASAYFAPLLAALGV 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881    249 LGLTFLSISLLFQSDYKKIIANWSVIHtgMGLILL---WHNDLLFIGILFFcNLSHIISSAFMFIMVGYMYDNFGLRifl 325
Cdd:COG1008 284 IGIIYGALVALAQTDLKRLIAYSSVSH--MGFVLLgifALNPLGLQGAVLQ-MVSHGLITAALFLLVGVLYDRTHTR--- 357

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881    326 IMTSFFGVS----IWSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIIcfyVIVLSVFVSSIYI 391
Cdd:COG1008 358 DIADLGGLAkrmpVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAI---LAALGLILTAAYL 424
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 176-383 1.23e-15

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 78.83  E-value: 1.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      176 IWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVMLGLTFLS 255
Cdd:TIGR01972 205 LFLAFFIAFAVKVPLFPLHTWLPDAHVEAPTAGSVILAGVLLKMGTYGFLRFNLPLFPDASLYFAPVLAALGVIAIIYGA 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      256 ISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYMYDNFGLRIFLIMTSFFGVSI 335
Cdd:TIGR01972 285 LIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYERAHTRDIAKYGGLANKMP 364

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 12881      336 WSSLFLGMFLF-NIDFPFMLLFYIDIFILYGLISLSFIY-IICFYVIVLS 383
Cdd:TIGR01972 365 VLAAFFMLFAMaSLGLPGTSGFVGEFLILLGSFKVNPVVaFLAALGIVLA 414
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 45-351 6.40e-14

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 73.42  E-value: 6.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      45 INIWFIFFMGLIVFFLVFLLTRKIVSYSKYFCIVCTYIFIYIDVVFIILidDFVCFMILFESLFFPICFVSLFFNFNNRF 124
Cdd:MTH00226 103 ISIYFIILTGFIVPCSILISWHSVKYLTKSFLICMLILEFLLYAVFSVL--DIFMFYILFEGVLIPMYLILGIWGSREEK 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     125 IFAIFYLVIVSSISSIMCIMICIIIIFHFNVLNLQSFIDICFFDSLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEV 204
Cdd:MTH00226 181 MQAAYYFFFYTLIGSVLMLLCLFSLYNIHGTTDYLTLASCSHVVSEQTQKWIFLGIFLAMAVKIPIFPFHIWLPKAHVEA 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     205 NTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVMLGLTFLSISLLFQSDYKKIIANWSVIHTGMGLILLW 284
Cdd:MTH00226 261 PVAGSVLLAGILLKLGGYGLVRLSWPILPLGAQNLAPAVIAMGIVGIVYGSFATCRQIDVKRLVAYSSVAHMGLVSITLV 340

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12881     285 HNDLLFIGILFFCNLSHIISSAFMFIMVGYMYDNFGLRIFLIMTSF-FGVSIWSSLFLGMFLFNIDFP 351
Cdd:MTH00226 341 THDIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTRLIKYYRGLsITMPIWGTIMIVTSLANVAVP 408
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 55-396 7.00e-14

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 7.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      55 LIVFFLVFLLTRKIVSYSKYFCIVCTYIFIYIDVVFIIlIDDFVCFMILFESLFFPICFVSLFFNFNNRFIFAIFYLVIV 134
Cdd:MTH00094  43 LLIFMMVFILGLVLLSEKNFNLLILSNLLILICLLFFV-SSNMLMLYMFFELSMFPILIMILGYGSQIEKINSSYYLLFY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     135 SSISSIMCIMICIIIIFHFNvlnlqsfidICFFDsLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLAS 214
Cdd:MTH00094 122 AAFFSFPFLFVYLKNFFFFS---------LCYFD-FFLSWEMFFILSLSFMMKFPVYFLHLWLPKAHVEAPTTASMLLAG 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     215 VVLKMGFFGVFKFL-FLAFNQVSIWFLgvidsMVMLGLTFLSISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGI 293
Cdd:MTH00094 192 LLLKLGTAGFLRILgSLNFVYNNFWII-----FSLLGMILSSFCCVFQSDSKSLAAYSSVTHMSFLLLSLVYMSMSGKLS 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     294 LFFCNLSHIISSAFMFIMVGYMYDNFGLRIFLIMTSFFGVSIWSSLFLGM-FLFNIDFPFMLLFYIDIFILYGLISLSFI 372
Cdd:MTH00094 267 GLMMMLAHGYTSTLMFYLIGEFYHISKSRLIYFMNSFFSSSMFFGLIFSLvFLSNSGVPPSLSFFSEFLIISNSFMKNKF 346

                        330       340
                 ....*....|....*....|....
gi 12881     373 YIICFYVIVLSVFVSSIYIYICLS 396
Cdd:MTH00094 347 SFFFIFFYFLVSFYYSLFLIVSSF 370
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 171-392 9.52e-13

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 69.70  E-value: 9.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     171 YLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVMLG 250
Cdd:MTH00217 203 ELQYFIFLGFFLSLAIKIPKIPFHIWLPQAHVEAPVAGSVILAGVLLKLGGYGFIRFSWPLLPEASEYFSPLIQTLSLLA 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     251 LTFLSISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYMYDNFGLRiflIMTSF 330
Cdd:MTH00217 283 IIYGSLTTCRQVDLKRIIAYSSVAHMGLVTLGIFSHTIQGLVAAIFLMLAHGLVSSALFIAVTFLYERHHTR---LIKYY 359

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12881     331 FGVSI----WSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIICFYVIVLSVFVSSIYIY 392
Cdd:MTH00217 360 RGMVItmplFGILMLLLVLANASIPLSCNFVGEFLSLLAAFEYSYIVGVLASLGMVLSAGYSIYLY 425
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
178-322 1.82e-12

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 68.96  E-value: 1.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     178 ILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKF---LFL-AFNQVSIWFLGVIDSMVMLGltf 253
Cdd:PRK06473 209 APILVGFGIKIPLVPFHTWLPDAHVEASTPVSVLLAGVLLKLGTYGLLRFgvgLFPeAWVYLAPWLATWAVVSVLYG--- 285

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12881     254 lSISLLFQSDYKKIIANWSVIHtgMGLILLWHNDLLFIGIL--FFCNLSHIISSAFMFIMVGYMYDNFGLR 322
Cdd:PRK06473 286 -ASCAIAQKDMKKMVAYSSIGH--MGYILLAAAAATPLSILaaVFQMISHGLISALLFLLVGVVYKKTGSR 353
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 42-390 2.96e-11

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 65.08  E-value: 2.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      42 LNYINIWFIFFMGLIVFFLVFLLTRKIVSYSKYFCIVCTYIFIYIDVVFIILidDFVCFMILFESLFFPICFVSLFFNFN 121
Cdd:MTH00204  81 VDGVSLFFILLTTLLIPICILISWKSIKFLFKEFLLCLLFLEVLLIGVFSVL--DLLLFYILFEGILIPMFLLIGIWGSR 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     122 NRFIFAIFYLVIVSSISSIMCIMICIIIIFHFNVLNLQSFIDICFFDSLylAIYIWILLFIMFAIKYPIWPLHVWLPEMH 201
Cdd:MTH00204 159 EEKVRASYYFFFYTFAGSVFMLLGIFQLYSITGTTDYQILLNIKLPLSI--QKWLLVGFFLSLAVKIPQIPFHIWLPQAH 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     202 VEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVMLGLTFLSISLLFQSDYKKIIANWSVIHTGMGLI 281
Cdd:MTH00204 237 VEAPVAGSVILAGILLKLGGYGFLRFSWPLFPAASEYFAPLIVMLSVIAVIYGSLTTCRQVDFKRLIAYSSVAHMGLVPL 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     282 LLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYMYDNFGLRIFLIMTSF-FGVSIWSSLFLGMFLFNIDFPFMLLFYIDI 360
Cdd:MTH00204 317 GLFTHTIEGLVAAVFLMLAHGFVSSALFIAVTFLYERHHTRLIKYYRGLtLTMPLFVIIMLVLSLANMGFPLSCNFVGEF 396

                        330       340       350
                 ....*....|....*....|....*....|
gi 12881     361 FILYGLISLSFIYIICfyvIVLSVFVSSIY 390
Cdd:MTH00204 397 FSLLAAFEYSLGLGVL---VTSGMVWSAAY 423
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 178-380 2.11e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 61.18  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      178 ILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLaFNQVSIWFLGVIDSMVMLGLTFLSIS 257
Cdd:pfam00361  86 LLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAATLVKAGGYGLIRRSLL-YLPSSPFIQQILLILAIISMLLGSLA 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      258 LLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYM-YDNFGLRIFLIMTSFF-GVSI 335
Cdd:pfam00361 165 ALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAGSViYRRVHTRNIRDYGGLAkTMPI 244

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 12881      336 WSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIICFYVI 380
Cdd:pfam00361 245 LALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVV 289
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 172-322 2.59e-10

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 62.09  E-value: 2.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881    172 LAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLG-VIDSMVMLG 250
Cdd:COG0651 203 LLLAAFALLLVGFGIKAALFPLHFWLPDAYPAAPSPVSALLSGLLTKVGVYAILRVLTLLFGADPALFLGtLLLVLGLLT 282

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12881    251 LTFLSISLLFQSDYKKIIANWSVIHtgMGLILLW---HNDLLFIGILFFCnLSHIISSAFMFIMVGYMYDNFGLR 322
Cdd:COG0651 283 MLVGALGALAQRDLKRLLAYSSVSQ--IGYILLGlglGTPLGLAGALFHL-LNHALAKALLFLAAGAIERATGTR 354
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 169-317 3.32e-10

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 61.97  E-value: 3.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     169 SLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVM 248
Cdd:PRK12561 180 PLALELLLYAGFLIAFGVKLPIFPLHTWLPDAHGEASAPVSMILAGVLLKMGGYALIRFNVQMLPDAHVYFAPALAILGV 259

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12881     249 LGLTFLSISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYMYD 317
Cdd:PRK12561 260 VNIIYGALNAFAQDNVKRRLAYSSVSHMGFVLLGIAAFTDLGISGAMLQMISHGLIAAALFFLTGVTYE 328
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-392 3.34e-10

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 61.71  E-value: 3.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881       1 MFKFTVILILFIMLFWSMLLLCINSSFSFACEIHNVYINVYLNYINI-----WFIFFMGLIVFFLVFLLTRKIVSYSKYF 75
Cdd:MTH00163   7 MLLFLIPLCFLKNSWWLVQSLLFLLSFLFMLLFSLSFYFSNISYFFGldllsFGLILLSFWICMLMILSSESVYKKNNYS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      76 CIVCTYI-FIYIDVVFIILIDDFVCFMILFESLFFPICFVSLFFNFNNRFIFAIFYLVIVSSISSIMCIMICiiiifhFN 154
Cdd:MTH00163  87 NLFLFLIlFLLIFLLLTFSSMNLLLFYIFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLFASLPLLVGI------FY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     155 VLNLQSFIDICFFDSLYLAIYIWILLFIM-FAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLaFN 233
Cdd:MTH00163 161 LYNNSGSLSFFLLNFFGSLNFLWYLSMILaFLVKMPMFFVHLWLPKAHVEAPVSGSMILAGVLLKLGGYGLLRVMSF-FS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     234 QVSIWFLGVIDSMVMLGLTFLSISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVG 313
Cdd:MTH00163 240 KLGLKFNYIWISISLVGGVIVSLICLRQVDLKSLIAYSSVAHMGLVLGGLMTFSYWGLMGSLLMMIGHGLCSSGLFCLAN 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     314 YMYDNFGLRIFLIMTSFFgvSIWSSLFLGMFLF---NIDFPFMLLFYIDIFILYGLISLSFIYIICFYVIVLSVFVSSIY 390
Cdd:MTH00163 320 IIYERLGSRSLLINKGLL--NFMPSMSLWWFLLsssNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLY 397


                 ..
gi 12881     391 IY 392
Cdd:MTH00163 398 LY 399
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 169-392 1.33e-08

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 56.39  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     169 SLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLaFNQVSIWFLGVIDSMVM 248
Cdd:MTH00150 147 LLSSMGLWGLLVFLAFLVKLPMYPFHLWLPKAHVEAPVAGSMILAGILLKLGGYGILRMMMV-FSLSSSSFSIFLISLSL 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     249 LGLTFLSISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYMYDNFGLRIFLIMT 328
Cdd:MTH00150 226 WGGVLTSLICLRQSDVKSLIAYSSVGHMSLVLAGVLSNTSWGWVGALIMMVSHGFCSSGLFCLANYTYEKVHSRSLFLSK 305

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12881     329 SffGVSIWSSLFLGMFLF---NIDFPFMLLFYIDIFILYGLISLSFIYIICFYVIVLSVFVSSIYIY 392
Cdd:MTH00150 306 G--MLMLYPSLSLWWFLFciiNMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLY 370
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 151-392 4.44e-08

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 54.99  E-value: 4.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     151 FHFNVLNLQSFIDICFFDSLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFlFL 230
Cdd:MTH00205 162 LNSLNFSLSMFFNFPLNFSDFYLFLYWIFLMLAFLVKLPMYFVHLWLPKAHVEAPVSGSMILAGVLLKLGGYGLIRI-TS 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     231 AFNQVSIWFLGVIDSMVMLGLTFLSISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFI 310
Cdd:MTH00205 241 MLYKLNSNFSELFFSISLWGGVMTGMICLRQVDLKSLIAYSSVGHMGLMVVGVFSNTSWGMNGAIIMMVAHGLCSSGMFA 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     311 MVGYMYDNFGLRIFLIMTSFFGVSIWSSLFLGMFL-FNIDFPFMLLFYIDIFILYGLISLSFIYIICFYVIVLSVFVSSI 389
Cdd:MTH00205 321 LANVNYERTNSRSMLMNKGVLNTFPFLVLMWFLLIsCNMAAPPSLNLASEILLIMSLLSSSKISGIPLSLISFLSGAYSL 400


                 ...
gi 12881     390 YIY 392
Cdd:MTH00205 401 YLY 403
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 60-278 6.80e-08

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 54.36  E-value: 6.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881      60 LVFLLTRKIVSYSKYFCIVCTYIFIYIDVVFI-ILIDDFVCFMILFESLFFPICFVSLFFNFNNRFIFAIFYLVIVSSIS 138
Cdd:MTH00014  74 LMILASFKIFQNNKAPKTFMTNILILNLILLLtFSASNLLMFYIFFEASLIPTLFLILGWGYQPERLQASFYLMIYTVTA 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     139 SIMCIMICIIIIFHFNVLNLqsFIDICFFDSLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLK 218
Cdd:MTH00014 154 SLPLLMSILLIFYTNNSLSM--LMSSMEPPSIYLMNLWWLITILAFMVKMPLYTVHLWLPKAHVEAPVAGSMILAGILLK 231

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     219 MGFFGVFKFLFLaFNQVSIWFLGVIDSMVMLGLTFLSISLLFQSDYKKIIANWSVIHTGM 278
Cdd:MTH00014 232 LGGYGLLRMSSL-FMHINKSLSAPFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGL 290
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 172-313 7.13e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 54.59  E-value: 7.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     172 LAIYIWILLFI-MFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSI------WFLGVID 244
Cdd:PRK12667 220 LALGVALALALwAFTIKAAIFPNHFWLPDAHPAAPSPVSAMLSGLVVNVGAYAIIRFLYTIFGISPSlidfraALSPILI 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12881     245 SMVMLGLTFLSISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVG 313
Cdd:PRK12667 300 ILGAVSAIIGALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASG 368
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 152-393 7.44e-08

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 54.17  E-value: 7.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     152 HFNVLNLQSFIDICFFDSLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFlFLA 231
Cdd:MTH00206 167 QNSLGSLSLYILYFSKLTTWNNNLWWLACILAFLVKLPLYGVHLWLPKAHVEAPVAGSMVLAGVLLKLGGYGMMRI-ILI 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     232 FNQVSIWFLGVIDSMVMLGLTFLSISLLFQSDYKKIIANWSVIHtgMGLILLWHNDLLFIGIL--FFCNLSHIISSAFMF 309
Cdd:MTH00206 246 LGPSTKLSSYFFIILGLWGSIMTSSICLRQTDLKSLIAYSSVSH--MSLVTAGILSGSPWGFKgaLLLMIAHGLVSSALF 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     310 IMVGYMYDNFGLRIFLIMTSF-FGVSIWSSLFLGMFLFNIDFPFMLLFYIDIFILYGLISLSFIYIICFYVIVLSVFVSS 388
Cdd:MTH00206 324 CLANLLYERSHTRTILGNRGLqMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSLFSWSNFTLPLLGLGFLFTAIYS 403


                 ....*
gi 12881     389 IYIYI 393
Cdd:MTH00206 404 LYMFV 408
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 180-317 1.12e-07

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 53.94  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     180 LFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIDSMVMLGLTFLSISLL 259
Cdd:PRK02546 219 LLIAYGVKLPIVPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALLRMNAGMLPDAHAQFAPLLIVLGVVNIIYAALTSF 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12881     260 FQSDYKKIIANWSVIHtgMGLILlwhndllfIGILFFCNL----------SHIISSAFMFIMVGYMYD 317
Cdd:PRK02546 299 AQRNLKRKIAYSSISH--MGFVL--------IGIGSFTDLgtsgamlqmiSHGLIGASLFFLVGATYD 356
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
151-283 1.72e-06

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 50.10  E-value: 1.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     151 FHFNVLNLQSFidicffdSLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFL 230
Cdd:PRK07363 189 FDYDAISTQNL-------SLNTQLILLTGLLLGFGIKIPLVPLHTWLPDAYTEASPAVAILLGGVLAKLGTYGLLRFGLQ 261

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 12881     231 AFNQVSIWFLGVIDSMVMLGLTFLSISLLFQSDYKKIIANWSVIHtgMGLILL 283
Cdd:PRK07363 262 LFPQTWSLVAPGLAIIGTISVIYGALSAIAQKDIKRMVAYSSIGH--MGYILV 312
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 177-281 4.00e-06

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 49.04  E-value: 4.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     177 WILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVF----------KFLFLAFNQVSIWflgvidSM 246
Cdd:MTH00124 196 WLACLMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAILLKLGGYGIIritlllpplsNTLHYPFLTLALW------GA 269

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 12881     247 VMLGLTFLSisllfQSDYKKIIANWSVIHtgMGLI 281
Cdd:MTH00124 270 LMTSLICLR-----QTDLKSLIAYSSVSH--MGLV 297
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 171-375 7.02e-06

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 48.22  E-value: 7.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     171 YLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNqVSIW--FLGVIDSMVM 248
Cdd:PRK08377 203 TVAQVGLALLIFGLAVEAELFPLNAWAPDAYQAAPHPITVMFSAFVVKAGLYAMARILYLMQN-ANGWssVLKLVIIMAT 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     249 LGLTFLSISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYM-----------YD 317
Cdd:PRK08377 282 LTVFFAELSALRQKNVKRMIAYSSIGQVGMIALALALGTQAGVDAGVFHMINHAIVKALLFLAVGYVgitlggteiekFE 361

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 12881     318 NFGLRIFLIMtsfFGVSIWSSLFLGMFLFNIdfpfmllFYIDIFILYGLISLSFIYII 375
Cdd:PRK08377 362 GLGKRMPLTA---LALTIGALSTVGIPLFNV-------FWSKFRIILAGLSAGYTWPV 409
ND4 MTH00062
NADH dehydrogenase subunit 4; Provisional
 160-378 1.01e-05

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214413 [Multi-domain]  Cd Length: 417  Bit Score: 47.61  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     160 SFIDICFFDSLYLAIYIwiLLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWF 239
Cdd:MTH00062 153 NFSDWGSDDSVSLIVYY--VLSFMFITKVPLFPFHTWLPIVHAEASSPVSIFLSGYIMKLGLLGVYRFCGFIFSGSFLGY 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     240 LGVIdsmVMLGLTFLsISLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYMYDNF 319
Cdd:MTH00062 231 LFLC---CLFSVFFL-ITACSELDGKRWLAFLSLSHILVPVLGLFVGDWSSINLSFFYCLGHGLSAGLVFLLLWCFYEVS 306

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12881     320 GLRIFLIMTSFFGVSIWSSLFLGM-FLFNIDFPFMLLFYIDIFILY-GLISLSFIYIICFY 378
Cdd:MTH00062 307 GSRNWVLLKSGINGSLVLRVIVVFsFLSLCSFPPTIQFFCEVFLVSsSFGVLVYLLFWCFY 367
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 161-275 2.19e-05

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 46.51  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     161 FIDICFFDSLYLAIY--IWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKfLFLAFNQVSIW 238
Cdd:MTH00044 179 LSELNWLTSLSSNSSsiWWIFCILAFLVKMPIYGFHLWLPKAHVEAPVAGSMILAAILLKLGGYGLIR-LINLFSLPSAN 257

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 12881     239 FLG-VIDSMVMLGLTFLSISLLFQSDYKKIIANWSVIH 275
Cdd:MTH00044 258 NISfILIVFCCWGALITSIICLRQTDLKALIAYSSVGH 295
ndhD CHL00011
NADH dehydrogenase subunit 4
 151-223 2.94e-05

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 46.09  E-value: 2.94e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12881     151 FHFNVLNLQSFidicffdSLYLAIYIWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFG 223
Cdd:CHL00011 195 LNFETLANQSY-------PVALEILFYIGFLIAYAVKLPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYG 260
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 179-283 3.29e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 46.03  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     179 LLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAF------NQVSIWFLGVIDSMVMLglt 252
Cdd:PRK08375 207 FVLLALALKAAVFPLHTWLPRAYPAAPPVVTALLSGLVTKVAVYALIRIYFTVFggdfrfALGLGWLLAVLALLSML--- 283

                         90       100       110
                 ....*....|....*....|....*....|.
gi 12881     253 FLSISLLFQSDYKKIIANWSVihTGMGLILL 283
Cdd:PRK08375 284 VGSLAALGQDDVKRVLAYSTV--SQMGYILL 312
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 178-370 8.24e-05

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 44.75  E-value: 8.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     178 ILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFK-FLFLAFNQVSIWFLGVIDSMVMLGLTFLSI 256
Cdd:PRK08676 210 LFIFIGFLAKSGLVPFHTWLPAAYAKAPSVVSALLSGTVLNIGIYGILRlSALLRQSGAAEQFSNVLIGLGIFSIAVAAF 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     257 SLLFQSDYKKIIANWSVIHTGMGLILLWHNDLLFIGILFFCNLSHIISSAFMFIMVGYMYDNFGLRIFLIMTSFF----- 331
Cdd:PRK08676 290 SMLSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHMLAHSLVKSGLFFSAGILHRQYRSDRFDRIFDVFrlqpv 369

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 12881     332 ---GVSIWSSLFLGMFLFnidfpfmLLFYIDIFILYGLISLS 370
Cdd:PRK08676 370 aawGVILGSAAIIGMPPF-------PLFLSKFFILLQLGGIS 404
PRK06521 PRK06521
hydrogenase 4 subunit B; Validated
 178-285 8.43e-05

hydrogenase 4 subunit B; Validated


Pssm-ID: 235820 [Multi-domain]  Cd Length: 667  Bit Score: 44.88  E-value: 8.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     178 ILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLaFNQVSIWFLGVidsmVMLGLTFLSIS 257
Cdd:PRK06521 214 LLALFGFGAKAGLVPLHVWLPRAHPAAPSHVSALMSGVMLKVAIYGILRVVFD-LLGAPGWWWGV----LVLALGAISAV 288

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 12881     258 L-----LFQSDYKKIIA-----NWSVIHTGMGLILLWH 285
Cdd:PRK06521 289 LgvlyaLAEHDLKRLLAystieNIGIIFVGLGLAMVFI 326
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 178-283 1.00e-04

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 44.54  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     178 ILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIdsMVMLGLT---FL 254
Cdd:PRK06458 218 VFLLIGFGTKVGLFPMHAWLPDAHSEAPSPVSALLSGVLLNVALYAVLRYYILIDAAIGSDFPGRL--LLIFGLLsvlVA 295

                         90       100
                 ....*....|....*....|....*....
gi 12881     255 SISLLFQSDYKKIIANWSVIHtgMGLILL 283
Cdd:PRK06458 296 AFFLLRQRDIKRLFAYSSIEH--MGLIAF 322
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 177-281 1.06e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 44.52  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     177 WILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLaFNQVSIWFLGVIDSMVMLGLTFLSI 256
Cdd:MTH00068 196 WLACLLAFMVKMPLYGLHLWLPKAHVEAPIAGSMILAAVLLKLGGYGILRISIL-LTPLSKELSYPFIILALWGVLMTSL 274

                         90       100
                 ....*....|....*....|....*
gi 12881     257 SLLFQSDYKKIIANWSVIHtgMGLI 281
Cdd:MTH00068 275 ICLRQTDLKSLIAYSSVSH--MGLV 297
PRK08667 PRK08667
hydrogenase membrane subunit; Validated
 176-313 4.92e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 236331 [Multi-domain]  Cd Length: 644  Bit Score: 42.41  E-value: 4.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     176 IWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLfLAFNQVSIWFLGVIDSMVMLGLTFLS 255
Cdd:PRK08667 207 VFLLLFLGFGIKAGIIPFHKWLPYAHPASPSNVSALMSGVMLKVAVYGLVRFL-MDVLSPELWWGVLILLAGSISALLGV 285

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12881     256 ISLLFQSDYKKIIA-----NWSVIHTGMGLILLWHND------LLFIGILFFCNLSHIISSAFMFIMVG 313
Cdd:PRK08667 286 IYALKEHDLKGLLAyssieNIGIILMGIGLYVIFGVYgldtlaLLALGGALFHSLNHALFKSLLFLTAG 354
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 177-278 5.76e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 42.25  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     177 WILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQVSIWFLGVIdSMVMLGLTFLSI 256
Cdd:MTH00127 197 WAGCLLAFLVKMPLYGVHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRMMVMLDPLTKELSYPFI-ILALWGIIMTGS 275

                         90       100
                 ....*....|....*....|..
gi 12881     257 SLLFQSDYKKIIANWSVIHTGM 278
Cdd:MTH00127 276 ICLRQTDLKSLIAYSSVSHMGL 297
PRK08042 PRK08042
formate hydrogenlyase subunit 3; Reviewed
 176-247 7.81e-04

formate hydrogenlyase subunit 3; Reviewed


Pssm-ID: 181206 [Multi-domain]  Cd Length: 593  Bit Score: 41.74  E-value: 7.81e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12881     176 IWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNQ-----VSIWFLGVIDSMV 247
Cdd:PRK08042 182 IWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGILTLSLLGGNAplwwgVALLVLGMITAFV 258
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 176-281 1.41e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 40.65  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     176 IWILLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVF----------KFLFLAFNQVSIWflgvidS 245
Cdd:MTH00110 195 LWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAILLKLGGYGMMritiilnpltEFMAYPFLMLSLW------G 268

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 12881     246 MVMlgltfLSISLLFQSDYKKIIANWSVIHtgMGLI 281
Cdd:MTH00110 269 MIM-----TSSICLRQTDLKSLIAYSSVSH--MALV 297
PRK07234 PRK07234
putative monovalent cation/H+ antiporter subunit D; Reviewed
 179-330 2.39e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235978 [Multi-domain]  Cd Length: 470  Bit Score: 39.94  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     179 LLFIMFAIKYPIWPLHVWLPEMHVEVNTEMSVLLASVVLKMGFFGVFKFLFLAFNqvsiwfLGVIDSMVMLGLTFLSISL 258
Cdd:PRK07234 189 LIALGLLVKGGIFVSGLWLPLTHSEAEPPVSALLSGVVVKAGVFPLVRCALDVPG------LDLIVRIFGVGTALLGVLF 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12881     259 -LFQSDYKKIIAnWSVIhTGMGLILLwhnDLLFIGILffcNLSHIISSAFMFIMVGYMYD-----------NFGLRIFLI 326
Cdd:PRK07234 263 aLLEKDLKRMLA-FSTI-SQLGFILA---APLVGGLY---ALAHGLVKSTLFLCAGALPSrnftelisqmlGIGKWIPLT 334


                 ....
gi 12881     327 MTSF 330
Cdd:PRK07234 335 MASF 338
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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