|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1232.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 2 SNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEASE 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 82 NDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNTG 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 162 TNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAETN 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 242 LKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 322 RNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 402 ERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 41511 482 LGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
41-341 |
4.25e-136 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 396.37 E-value: 4.25e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 41 KVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDpEASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQR 120
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 121 VWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDmykEVNTGTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYqetk 200
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 201 aLLTPGK----LKNYLVEKMRTLGTAACPPYHIAFVIGGTsAETNLKTVKLASAKYYDELPTEgnehgqaFRDVELEKEL 276
Cdd:COG1951 155 -MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEEL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41511 277 LIEAQNLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRQGIWieKLEHN 341
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-537 |
1.24e-133 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 386.44 E-value: 1.24e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 332 GIWIEKLEHNPGKYIPEELRKAGEgEAVRVDLNRPmkEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDNGEGLP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEEDDLA-EAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 412 QYIKD--HPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 41511 490 AVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
372-537 |
3.77e-79 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 245.81 E-value: 3.77e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 372 AQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDNGEGLPQYIKDHPIYYAGPAKTPEGYA-SGSLGPTTAGRMDSYVDQ 450
Cdd:TIGR00723 1 EQILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 451 LQAQGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKSLECVEYPELGM-EAIWKIEVEDF-PAFILVD 528
Cdd:TIGR00723 81 LLEKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAID 159
|
....*....
gi 41511 529 DKGNDFFQQ 537
Cdd:TIGR00723 160 SHGNSIFQE 168
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1232.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 2 SNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEASE 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 82 NDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNTG 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 162 TNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAETN 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 242 LKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 322 RNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 402 ERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 41511 482 LGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| PRK15391 |
PRK15391 |
class I fumarate hydratase; |
1-548 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185289 [Multi-domain] Cd Length: 548 Bit Score: 1175.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 1 MSNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEAS 80
Cdd:PRK15391 1 MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 81 ENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNT 160
Cdd:PRK15391 81 ENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEEALSKGVYNTYIEDNLRYSQNAALDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 161 GTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
Cdd:PRK15391 161 GTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 241 NLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
Cdd:PRK15391 241 NLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 321 DRNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKL 400
Cdd:PRK15391 321 DRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 401 KERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGF 480
Cdd:PRK15391 401 KELIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41511 481 YLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRCVK 548
Cdd:PRK15391 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
|
|
| PRK15390 |
PRK15390 |
fumarate hydratase FumA; Provisional |
1-548 |
0e+00 |
|
fumarate hydratase FumA; Provisional
Pssm-ID: 185288 [Multi-domain] Cd Length: 548 Bit Score: 1148.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 1 MSNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEAS 80
Cdd:PRK15390 1 MSNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 81 ENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNT 160
Cdd:PRK15390 81 ENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 161 GTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
Cdd:PRK15390 161 GTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 241 NLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
Cdd:PRK15390 241 NLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 321 DRNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKL 400
Cdd:PRK15390 321 DRNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 401 KERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGF 480
Cdd:PRK15390 401 KERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41511 481 YLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRCVK 548
Cdd:PRK15390 481 YLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRCVK 548
|
|
| PTZ00226 |
PTZ00226 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 240319 [Multi-domain] Cd Length: 570 Bit Score: 1000.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 2 SNKPFHYQAPFPLK--KDDTEYYLLT--SEHVSVSEF--EGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILR 75
Cdd:PTZ00226 25 VNPEFNFVPIFQPVdpHDTEEYRRLEdlSDYVEVVEVggGGKEILKVPPEALTKLTSYAFSDIQHFLRKSHLAQLRRILD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 76 DPEASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMY 155
Cdd:PTZ00226 105 DPEASDNDRFVAMTLLKNACIAAGRVLPGCQDTGTAIVLGKRGELIWTGGEDEKALSKGVYNAYTNRNLRYSQLAPLDMF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 156 KEVNTGTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGG 235
Cdd:PTZ00226 185 DEKNTGCNLPAQIDLYATPGNEYEFLFIAKGGGSANKTFLYQQTKSLLNPKSLRKFLEEKIKTIGTSACPPYHLAVVIGG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 236 TSAETNLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMG 315
Cdd:PTZ00226 265 LSAEMTLKTVKLASCRYYDSLPTSGDEYGRAFRDLEWEEIILEKTQNIGIGAQFGGKYFAHDVRVIRLPRHGASCPIGIG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 316 VSCSADRNIKAKINRQGIWIEKLEHNPGKYIPEELRKA-GEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRD 394
Cdd:PTZ00226 345 VSCSADRQILAKINKDGVYLEQLEHDPAQYLPDITEDDlSKTPVVKIDLNQPMEEILKQLSKYPVKTRLSLTGTLIVARD 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 395 IAHAKLKERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDAC 474
Cdd:PTZ00226 425 IAHAKIVEMLENGEPLPEYMKNHPIYYAGPAKTPDGYASGSFGPTTAGRMDSYVDLFMENGGSFITLAKGNRSKAVTNAC 504
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41511 475 KKHGGFYLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:PTZ00226 505 KKYGGFYLGSIGGPAAILAKDNIKKVEVLDFPELGMEAVWKIEVENFPAFIVVDDKGNDFYSQ 567
|
|
| PLN00133 |
PLN00133 |
class I-fumerate hydratase; Provisional |
5-539 |
0e+00 |
|
class I-fumerate hydratase; Provisional
Pssm-ID: 215068 [Multi-domain] Cd Length: 576 Bit Score: 930.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 5 PFHYQAPF-PLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEASEND 83
Cdd:PLN00133 40 AFDYQPLFdSNAKKTVPWRKLTGDHVSVVEAAGEKYLKVAPEALTLLSDTAMRDVAHLLRPGHLQQLRNILDDPEASDND 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 84 KYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNTGTN 163
Cdd:PLN00133 120 RFVALELLKNANIAAGRVLPGCQDTGTAIVMGKRGQRVLTDGEDEEHLSRGVYDAYTDTNLRYSQVAPLDMFEEKNTGTN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 164 LPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAETNLK 243
Cdd:PLN00133 200 LPAQIDLYAAKGDEYHFQFIAKGGGSANKTFLYQQTKALLNEGSLEAFLEEKIKTIGTSACPPYHLAIVIGGLSAEQNLK 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 244 TVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRN 323
Cdd:PLN00133 280 TVKLASTRYYDTLPTSGNALGRAFRDLEWEEKILKMTRGLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSADRQ 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 324 IKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKLKER 403
Cdd:PLN00133 360 ALGKITKDGVFLEALETDPSKYLPDVTEDSLSDDVVKVDLNRPMSEIRETLSAHPVRTRLSLTGTLVVARDIAHAKLLER 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 404 MDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGFYLG 483
Cdd:PLN00133 440 LEAGEGLPQYAKDHIIYYAGPAKTPEGYASGSFGPTTAGRMDSYVDRFMAAGGSFVTLAKGNRSAQVTNACKKHGGFYLG 519
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 41511 484 SIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQ 539
Cdd:PLN00133 520 SIGGPAAILAQNCIKKVEVLENPELGMEAVWKIEVEDFPAFIVVDDKGNDFFKKWQ 575
|
|
| PRK15392 |
PRK15392 |
class I fumarate hydratase; |
3-546 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185290 [Multi-domain] Cd Length: 550 Bit Score: 912.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 3 NKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEASEN 82
Cdd:PRK15392 2 SKPFIWQEPFLQNKDGTEYTLISDQHITVTELDGEEVIKIAPEALTLLARQAFYEASFFLRSAHLQQVASILNDPQASSN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 83 DKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNTGT 162
Cdd:PRK15392 82 DKYVALQLLRNAEVSAKGVLPNCQDTGTATIVASKGQQIWTGGNDAEALSKGIYSTFQENNLRFSQNAPLDMYTEVNTQT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 163 NLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAETNL 242
Cdd:PRK15392 162 NLPAQIDISAVAGDEYHFLCVNKGGGSANKAALYQETKSLLQPEKLTAFLIEKMKSLGTAACPPYHIAFVVGGLSADQTL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 243 KTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADR 322
Cdd:PRK15392 242 KVAKLASTKYYDNLPTSGNEQGQAFRDIELEKVLLEASQQFGIGAQFGGKYFAHDIRVIRLPRHGGSCPIAMALSCSADR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 323 NIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKLKE 402
Cdd:PRK15392 322 NIKAKINKHGIWLEKLEHNPGQYIPASLREENHAQHVQLDLNRPLRDVMQDLARLPVGTRVSLSGPIVVARDIAHAKIKA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 403 RMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGFYL 482
Cdd:PRK15392 402 RLDSGEPMPEYLKHHIVYYAGPAKTPENMACGSLGPTTGGRMDGYVDTFQAAGGSLVMLSKGNRSQQVTDACHKHGGFNL 481
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41511 483 GSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI-QLTQCTRC 546
Cdd:PRK15392 482 GSIGGAAALLAQEYVKSLRCLEYPELGMEAVWMMEVENLPAFILVDDKGNNFFSQFeQQHRCASC 546
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
41-341 |
4.25e-136 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 396.37 E-value: 4.25e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 41 KVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDpEASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQR 120
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 121 VWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDmykEVNTGTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYqetk 200
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 201 aLLTPGK----LKNYLVEKMRTLGTAACPPYHIAFVIGGTsAETNLKTVKLASAKYYDELPTEgnehgqaFRDVELEKEL 276
Cdd:COG1951 155 -MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEEL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41511 277 LIEAQNLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRQGIWieKLEHN 341
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-537 |
1.24e-133 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 386.44 E-value: 1.24e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 332 GIWIEKLEHNPGKYIPEELRKAGEgEAVRVDLNRPmkEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDNGEGLP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEEDDLA-EAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 412 QYIKD--HPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 41511 490 AVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| Fumerase |
pfam05681 |
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase ... |
48-324 |
1.09e-116 |
|
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.
Pssm-ID: 461713 Cd Length: 267 Bit Score: 345.94 E-value: 1.09e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 48 TLLARQAFHDASFMLRPAHQQQVADILRDpEASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGD 127
Cdd:pfam05681 1 TEAVAELIIEASTYLPPDVLEALKKALEK-EESPNAKFVLEQILENAEIAAEEKLPICQDTGMAVVFVKIGQDVHIEGGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 128 -EAALARGVYNTYIEDNLRYSQNA-PLDmykEVNTGTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYqetkaLLTP 205
Cdd:pfam05681 80 lEEAINEGVRRAYTEGPLRKSVVAdPLT---RKNTGDNTPAVIHIEIVPGDELKITVAPKGGGSENMSALK-----MLNP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 206 G----KLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKlASakyYDELPTEG-NEHGQafrdvELEKELLIEA 280
Cdd:pfam05681 152 AdgleGVKKFVLETVKEAGPNACPPYIVGVGIGGTFEKAALLAKK-AL---LRPLGTRNpDPRGA-----ELEEELLEAI 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 41511 281 QNLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNI 324
Cdd:pfam05681 223 NKLGIGPQgLGGKTTALDVHIERAPTHIASLPVAVNVQCWADRHA 267
|
|
| FumA |
COG1838 |
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy ... |
359-539 |
4.95e-99 |
|
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441443 Cd Length: 190 Bit Score: 297.79 E-value: 4.95e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 359 VRVDLNRPMKEIlaQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGP 438
Cdd:COG1838 2 ATIRLNTPLTEE--DVRKLKAGDRVLLSGTIYTARDAAHKRLVELLDRGEPLPVDLKGQVIYYVGPAPAKPGYVIGSAGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 439 TTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKSLECVEYPELGMEAIWKIEV 518
Cdd:COG1838 80 TTSTRMDKYTPELLEELGLKGMIGKGGRSPEVIEAMKKHGAVYLAAVGGAAALLAK-AIKKVEVVAYEDLGPEAIWKLEV 158
|
170 180
....*....|....*....|.
gi 41511 519 EDFPAFILVDDKGNDFFQQIQ 539
Cdd:COG1838 159 EDFPLIVAIDSKGNSLYEQGR 179
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
372-537 |
3.77e-79 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 245.81 E-value: 3.77e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 372 AQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDNGEGLPQYIKDHPIYYAGPAKTPEGYA-SGSLGPTTAGRMDSYVDQ 450
Cdd:TIGR00723 1 EQILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 451 LQAQGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKSLECVEYPELGM-EAIWKIEVEDF-PAFILVD 528
Cdd:TIGR00723 81 LLEKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAID 159
|
....*....
gi 41511 529 DKGNDFFQQ 537
Cdd:TIGR00723 160 SHGNSIFQE 168
|
|
| PRK06842 |
PRK06842 |
Fe-S-containing hydro-lyase; |
385-536 |
4.02e-45 |
|
Fe-S-containing hydro-lyase;
Pssm-ID: 180724 [Multi-domain] Cd Length: 185 Bit Score: 157.26 E-value: 4.02e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 385 LNGTIIVGRDIAHAKLKERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQgGSMIMLAKG 464
Cdd:PRK06842 25 ISGYIYTARDAAHKRLIELLDKGEELPIDIKDQIIYYVGPSPAKPGKVIGSAGPTTSYRMDAYAPRLLDI-GLKGMIGKG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41511 465 NRSQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PRK06842 104 ARSDEVIESIKKNKAVYFGAIGGAAALIAK-SIKKSEVIAYEDLGAEAIRKLEVKDFPVVVIIDSEGNNLYE 174
|
|
| PRK06246 |
PRK06246 |
fumarate hydratase; Provisional |
78-328 |
6.61e-36 |
|
fumarate hydratase; Provisional
Pssm-ID: 180486 Cd Length: 280 Bit Score: 135.30 E-value: 6.61e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 78 EASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGD-EAALARGVYNTYIEDNLRysQNAPLDMYK 156
Cdd:PRK06246 39 EESPIGKEILKAILENAEIAKEEQVPLCQDTGMAVVFVEIGQDVHIEGGDlEDAINEGVRKGYEEGYLR--KSVVADPLT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 157 EVNTGTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLyqetkALLTPG----KLKNYLVEKMRTLGTAACPPYHIAFV 232
Cdd:PRK06246 117 RKNTGDNTPAVIHTEIVPGDKLKITVAPKGGGSENMSAL-----KMLKPAdgleGIKKFVLETVKEAGGNPCPPIIVGVG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 233 IGGTsAETNLKTVKLAsakyydelptegnehgqAFRDV----------ELEKELLIEAQNLGLGAQ-FGGKYFAHDIRVI 301
Cdd:PRK06246 192 IGGT-FDKAAKLAKKA-----------------LLRPIgernpdpeiaALEEELLEEINKLGIGPMgLGGKTTALDVKIE 253
|
250 260
....*....|....*....|....*..
gi 41511 302 RLPRHGASCPVGMGVSCSADRNIKAKI 328
Cdd:PRK06246 254 TYPCHIASLPVAVNIQCHAARHAEVVL 280
|
|
| ttdA_fumA_fumB |
TIGR00722 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S ... |
76-328 |
5.82e-34 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase alpha chain and the N-terminal region of the class I fumarase (where the C-terminal region is homologous to the tartrate dehydratase beta chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 273234 Cd Length: 273 Bit Score: 129.89 E-value: 5.82e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 76 DPEASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDmy 155
Cdd:TIGR00722 29 DREESEIAKINLEAILDNIEIAEKLGVPVCQDTGVPIFFVKVGSRFVLIGKLYEAIKQGVEEATEEVPLRPNAVHPLT-- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 156 kEVNTGTNL---PAQIDLYAVDGDEYKFLCIAKGGGSANKTYLyqetkALLTPG----KLKNYLVEKMRTLGTAACPPYH 228
Cdd:TIGR00722 107 -RENTGDNTglgVPQIHVEIVPGDELEIVVFPKGAGSENPSAL-----KMLKPSdgieGVKKFVLETVKNAGGKPCPPII 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 229 IAFVIGGTsAETNLKTVKLASakyydeLPTEGNEHGQAfRDVELEKELLIEAQNLGLGAQ-FGGKYFAHDIRVIRLPRHG 307
Cdd:TIGR00722 181 VGVGIGGS-FETAAKLAKKAL------LRPIGERHPNP-KIAKLELELLEEINSLGIGPMgLGGKTTALDVKIESAHCHT 252
|
250 260
....*....|....*....|.
gi 41511 308 ASCPVGMGVSCSADRNIKAKI 328
Cdd:TIGR00722 253 ASLPVAVNIQCWAHRRATLVV 273
|
|
| PRK08228 |
PRK08228 |
L(+)-tartrate dehydratase subunit beta; Validated |
385-537 |
1.14e-25 |
|
L(+)-tartrate dehydratase subunit beta; Validated
Pssm-ID: 236192 Cd Length: 204 Bit Score: 104.37 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 385 LNGTIIVGRDIAHAKLKERmdnGEGLPQYIKDHPIYYAGP----AKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIM 460
Cdd:PRK08228 26 LTGTLVTCRDVAHRRLIEL---GRELPVDLNGGAIFHAGPivrpKKNDDKFEMVSVGPTTSMRMEKFEKEFIEQTGVKLI 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41511 461 LAKGNRSQQVTDACKKHGGFYLGSIGGpAAVLAQGSIKSLECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQ 537
Cdd:PRK08228 103 VGKGGMGPGTEEGCQEFKALHCVFPAG-CAVLAATQVEEIEDAQWRDLGMpETLWVCRVKEFgPLIVSIDTHGNNLFEE 180
|
|
| PRK06043 |
PRK06043 |
fumarate hydratase; Provisional |
385-539 |
1.65e-25 |
|
fumarate hydratase; Provisional
Pssm-ID: 180366 Cd Length: 192 Bit Score: 103.69 E-value: 1.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 385 LNGTIIVGRDIAHAKLKERMDNGEGLPQYIKDHPIYYAGP--AKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLA 462
Cdd:PRK06043 25 ISGEILTARDEAHARILEMKEKGKELPFSLEGAVIYHCGPlmKKTDEGWKVVSAGPTTSARMSKMTPKLLEKVEVRAIIG 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41511 463 KGNRsQQVTDACKKhGGFYLGSIGGPAAvLAQGSIKSLECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQIQ 539
Cdd:PRK06043 105 KGGM-KNVADALKG-KCVYLAYTGGCAA-LAAESIKRVKAVHWLDLGMpEAVWVLEVEEFgPLIVGIDAKGNDLYSEVR 180
|
|
| PRK08395 |
PRK08395 |
fumarate hydratase; Provisional |
379-536 |
2.96e-16 |
|
fumarate hydratase; Provisional
Pssm-ID: 169425 Cd Length: 162 Bit Score: 76.39 E-value: 2.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 379 VSTRLSLNGTIIVGRDIAHAKLKErmdngEGLPQYIKDHPIYYAGPAKTPEGYASGslGPTTAGRMDSYVDQLQAQGGSM 458
Cdd:PRK08395 17 AGDVVYLSGIIYTARDLAHRRFLS-----EGFPFNPEGAVIYHCGPLVKNKKIVSA--GPTTSARMNKYLDFLFSLGVRG 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41511 459 IMLAKGNRSQQVtdackKHGGFYLGSIGGpAAVLAQGSIKSLECVEYPELGM-EAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PRK08395 90 IIGKGGMNAEPF-----KGRAVYFAFPGG-AGSLAAKSIKRVRDVYWEDLGMpDAVWELEVEDFPLLVAIDSKGRSLYR 162
|
|
| PRK08230 |
PRK08230 |
tartrate dehydratase subunit alpha; Validated |
74-330 |
1.60e-10 |
|
tartrate dehydratase subunit alpha; Validated
Pssm-ID: 181309 Cd Length: 299 Bit Score: 62.42 E-value: 1.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 74 LRDPEASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYsqNApLD 153
Cdd:PRK08230 36 LKDAETSPLAKIIYDTMFENQQLAIDLNRPSCQDTGVIQFFVKVGARFPLLGELESILKEAVEEATVKAPLRH--NA-VE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 154 MYKEVNTGTNLPAQI---DLYAV-DGDEYKFLCIAKGGGSAnktyLYQETKALLtPGK----LKNYLVEKMRTLGTAACP 225
Cdd:PRK08230 113 TFDEYNTGKNTGSGVpwvFWEIVpDSDDAEIEVYMAGGGCT----LPGRAKVLM-PGEgyegVVKFVFDVITSYGVNACP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41511 226 PYHIAFVIgGTSAETNLKTVKLASakyydeLPTEGNEHGQAfRDVELEKeLLIEAQN-LGLGAQ-FGGKYFAHDIRVIRL 303
Cdd:PRK08230 188 PLLVGVGI-ATSVETAAVLSKKAI------LRPIGSRNPNP-RAAELEK-RLEEGLNrIGLGPQgLTGNSSVMGVNIESA 258
|
250 260
....*....|....*....|....*..
gi 41511 304 PRHGASCPVGMGVSCSADRNIKAKINR 330
Cdd:PRK08230 259 ARHPSTIGVAVSTGCWAHRRGTIVFDA 285
|
|
| |
