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Conserved domains on  [gi|2453163199|dbj|BDY09446|]
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NADH dehydrogenase subunit I (chloroplast) [Lysimachia hypericoides]

Protein Classification

NAD(P)H-quinone oxidoreductase subunit I( domain architecture ID 11413996)

NAD(P)H-quinone oxidoreductase subunit I is a component of NDH, which shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ndhI CHL00014
NADH dehydrogenase subunit I
 4-166 5.54e-140

NADH dehydrogenase subunit I


:

Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 386.04  E-value: 5.54e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199   4 MVTGFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDW 83
Cdd:CHL00014    1 MVTGFMNYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  84 KFEPDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTILNSPQ 163
Cdd:CHL00014   81 KLETDIRKKRLLNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTISNSPQ 160


                  ...
gi 2453163199 164 SKN 166
Cdd:CHL00014  161 IKI 163
 
Name Accession Description Interval E-value
ndhI CHL00014
NADH dehydrogenase subunit I
 4-166 5.54e-140

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 386.04  E-value: 5.54e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199   4 MVTGFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDW 83
Cdd:CHL00014    1 MVTGFMNYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  84 KFEPDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTILNSPQ 163
Cdd:CHL00014   81 KLETDIRKKRLLNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTISNSPQ 160


                  ...
gi 2453163199 164 SKN 166
Cdd:CHL00014  161 IKI 163
ndhI TIGR00403
NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]
 1-164 1.27e-114

NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]


Pssm-ID: 129498 [Multi-domain]  Cd Length: 183  Bit Score: 322.63  E-value: 1.27e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199   1 MFPMVTGFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPV 80
Cdd:TIGR00403   1 MFNILKGVGDYAQQSIQAARYIGQGFAVTLDHMNRLPITIQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  81 VDWKFEPDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTILN 160
Cdd:TIGR00403  81 VDWEFNKAIKKKQLKNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYDQIALGRLPISITEDPTITPIRN 160


                  ....
gi 2453163199 161 SPQS 164
Cdd:TIGR00403 161 LTYL 164
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 62-134 3.22e-18

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 74.01  E-value: 3.22e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2453163199  62 DKCIACEVCVRVCPIDLPVVDWKFEPDIrkkrllnYSIDFGICIFCGNCVEYCPTNCLSMTeEYELSTYDRHE 134
Cdd:COG1143     2 DKCIGCGLCVRVCPVDAITIEDGEPGKV-------YVIDPDKCIGCGLCVEVCPTGAISMT-PFELAVEDREE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 62-139 5.82e-13

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 62.03  E-value: 5.82e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2453163199  62 DKCIACEVCVRVCPIDLPvvdwKFEPDIRKKRLLNysIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQ 139
Cdd:cd10549     6 EKCIGCGICVKACPTDAI----ELGPNGAIARGPE--IDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDE 77
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 64-118 1.14e-08

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 48.68  E-value: 1.14e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2453163199  64 CIACEVCVRVCPIDLPVVDWKFEPDIRKKrllnYSIDFGICIFCGNCVEYCPTNC 118
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKT----VVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 62-118 3.39e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 36.76  E-value: 3.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  62 DKCIACEVCVRVCP---IDLpvVDWKfePDIRKKrllnysidfgiCIFCGNCVEYCPTNC 118
Cdd:NF038196  185 DKCIGCGICAKVCPvnnIEM--EDGK--PVWGHN-----------CTHCLACIHRCPKEA 229
 
Name Accession Description Interval E-value
ndhI CHL00014
NADH dehydrogenase subunit I
 4-166 5.54e-140

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 386.04  E-value: 5.54e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199   4 MVTGFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDW 83
Cdd:CHL00014    1 MVTGFMNYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  84 KFEPDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTILNSPQ 163
Cdd:CHL00014   81 KLETDIRKKRLLNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTISNSPQ 160


                  ...
gi 2453163199 164 SKN 166
Cdd:CHL00014  161 IKI 163
ndhI TIGR00403
NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]
 1-164 1.27e-114

NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]


Pssm-ID: 129498 [Multi-domain]  Cd Length: 183  Bit Score: 322.63  E-value: 1.27e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199   1 MFPMVTGFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPV 80
Cdd:TIGR00403   1 MFNILKGVGDYAQQSIQAARYIGQGFAVTLDHMNRLPITIQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  81 VDWKFEPDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTILN 160
Cdd:TIGR00403  81 VDWEFNKAIKKKQLKNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYDQIALGRLPISITEDPTITPIRN 160


                  ....
gi 2453163199 161 SPQS 164
Cdd:TIGR00403 161 LTYL 164
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
21-149 5.01e-59

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 180.85  E-value: 5.01e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  21 YIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFD-----KCIACEVCVRVCPIDLPVVDWKFEPDiRKKRLL 95
Cdd:PRK05888   12 ELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDpngeeRCIACKLCAAICPADAITIEAAERED-GRRRTT 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  96 NYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSV 149
Cdd:PRK05888   91 RYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRV 144
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 25-142 1.72e-55

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 170.67  E-value: 1.72e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  25 GFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEF-----DKCIACEVCVRVCP-IDLPVVDWkfEPDIRKKRLLNYS 98
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRdpngeEKCIGCTLCAAVCPaDAIRVVPA--EGEDGKRRLKFYE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2453163199  99 IDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIAL 142
Cdd:TIGR01971  79 INFGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 37-134 1.18e-21

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 84.50  E-value: 1.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  37 PVTIQYP-YEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVvdwkFEPDIRKKRLLNysidfGICIFCGNCVEYCP 115
Cdd:PRK08348   16 PATNLFPaTEPVPVPEDFRGKILYDVDKCVGCRMCVTVCPAGVFV----YLPEIRKVALWT-----GRCVFCGQCVDVCP 86

                          90
                  ....*....|....*....
gi 2453163199 116 TNCLSMTEEYELSTYDRHE 134
Cdd:PRK08348   87 TGALQMSDDFLLASYDRFD 105
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 37-135 1.70e-21

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 85.85  E-value: 1.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  37 PVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWkfepDIRKKRLLnYSIDFGICIFCGNCVEYCPT 116
Cdd:PRK12387   13 TATSSYPLEPIAVDKNFRGKPEYNPQQCIGCAACVNACPSNALTVET----DLATGELA-WEFNLGRCIFCGRCEEVCPT 87

                          90
                  ....*....|....*....
gi 2453163199 117 NCLSMTEEYELSTYDRHEL 135
Cdd:PRK12387   88 AAIKLSQEFELAVWKKEDL 106
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 62-134 3.22e-18

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 74.01  E-value: 3.22e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2453163199  62 DKCIACEVCVRVCPIDLPVVDWKFEPDIrkkrllnYSIDFGICIFCGNCVEYCPTNCLSMTeEYELSTYDRHE 134
Cdd:COG1143     2 DKCIGCGLCVRVCPVDAITIEDGEPGKV-------YVIDPDKCIGCGLCVEVCPTGAISMT-PFELAVEDREE 66
PRK13984 PRK13984
putative oxidoreductase; Provisional
 35-125 9.54e-18

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 79.43  E-value: 9.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  35 RLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPID-LPVVDWKFEPDIRKKRLLNYSIDFGICIFCGNCVEY 113
Cdd:PRK13984   18 RKPVTIKVPNVKREAAERYRGFHINDWEKCIGCGTCSKICPTDaITMVEVPDLPQEYGKKPQRPVIDYGRCSFCALCVDI 97

                          90
                  ....*....|..
gi 2453163199 114 CPTNCLSMTEEY 125
Cdd:PRK13984   98 CTTGSLKMTREY 109
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 38-135 9.34e-14

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 65.54  E-value: 9.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  38 VTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKFEPDIRKKRLLnysidFGICIFCGNCVEYCPTN 117
Cdd:PRK08222   14 ATVKYPFAPLEVSPGFRGKPDLMPSQCIACGACTCACPANALTIQTDDQQNSRTWQLY-----LGRCIYCGRCEEVCPTR 88

                          90
                  ....*....|....*...
gi 2453163199 118 CLSMTEEYELSTYDRHEL 135
Cdd:PRK08222   89 AIQLTNNFELTVTNKADL 106
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 62-139 5.82e-13

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 62.03  E-value: 5.82e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2453163199  62 DKCIACEVCVRVCPIDLPvvdwKFEPDIRKKRLLNysIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQ 139
Cdd:cd10549     6 EKCIGCGICVKACPTDAI----ELGPNGAIARGPE--IDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDE 77
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 46-126 6.89e-13

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 62.03  E-value: 6.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  46 KLITSERFRGRIHFEFDKCIACEVCVRVCPID-LPVVDWKFEPDIRKKrllNYSIDFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:cd10549    24 ELGPNGAIARGPEIDEDKCVFCGACVEVCPTGaIELTPEGKEYVPKEK---EAEIDEEKCIGCGLCVKVCPVDAITLEDE 100


                  ..
gi 2453163199 125 YE 126
Cdd:cd10549   101 LE 102
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
62-126 1.19e-11

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 57.05  E-value: 1.19e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2453163199  62 DKCIACEVCVRVCPIDLPVVDWKFepdirkkrllnYSIDFGICIFCGNCVEYCPTNCLSMTEEYE 126
Cdd:COG2768    11 EKCIGCGACVKVCPVGAISIEDGK-----------AVIDPEKCIGCGACIEVCPVGAIKIEWEED 64
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 62-122 4.09e-11

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 57.41  E-value: 4.09e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2453163199  62 DKCIACEVCVRVCPIDLpvvdwkfepdIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMT 122
Cdd:cd10549    78 EKCIGCGLCVKVCPVDA----------ITLEDELEIVIDKEKCIGCGICAEVCPVNAIKLV 128
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 55-126 2.84e-10

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 53.56  E-value: 2.84e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDLpvvdwkFEPDIRKKRLLNYSIDFgiCIFCGNCVEYCPTNCLSMTEEYE 126
Cdd:COG1146     1 MMPVIDTDKCIGCGACVEVCPVDV------LELDEEGKKALVINPEE--CIGCGACELVCPVGAITVEDDEP 64
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 56-126 5.54e-10

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 53.13  E-value: 5.54e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2453163199  56 RIHFEFDKCIACEVCVRVCPidlpvvdwkfEPDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYE 126
Cdd:COG1144    24 RPVVDEDKCIGCGLCWIVCP----------DGAIRVDDGKYYGIDYDYCKGCGICAEVCPVKAIEMVPEEK 84
NapF COG1145
Ferredoxin [Energy production and conversion];
62-124 1.02e-09

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 55.50  E-value: 1.02e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  62 DKCIACEVCVRVCPID-LPVVDWKFEPDIRKKRllnysidfgiCIFCGNCVEYCPTNCLSMTEE 124
Cdd:COG1145   182 EKCIGCGLCVKVCPTGaIRLKDGKPQIVVDPDK----------CIGCGACVKVCPVGAISLEPK 235
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 55-123 2.12e-09

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 52.66  E-value: 2.12e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDlpVVDWKFEpdirkkrlLNYSIdfgICIFCGNCVEYCPTNCLSMTE 123
Cdd:cd16370    76 GGVVLDKEKCIGCGNCVKACIVG--AIFWDEE--------TNKPI---ICIHCGYCARYCPHDVLAMEE 131
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
56-122 2.60e-09

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 54.30  E-value: 2.60e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2453163199  56 RIHFEFDKCIACEVCVRVCPIDLpvvdwkfepDIRKKRLLNYSidfgiCIFCGNCVEYCPTNCLSMT 122
Cdd:COG0348   204 RVRYDRGDCIDCGLCVKVCPMGI---------DIRKGEINQSE-----CINCGRCIDACPKDAIRFS 256
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 54-123 9.82e-09

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 49.34  E-value: 9.82e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  54 RGRIHFEFDKCIACEVCVRVCPIDLpvvdwkfepdIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTE 123
Cdd:COG1149     3 RKIPVIDEEKCIGCGLCVEVCPEGA----------IKLDDGGAPVVDPDLCTGCGACVGVCPTGAITLEE 62
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 64-118 1.14e-08

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 48.68  E-value: 1.14e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2453163199  64 CIACEVCVRVCPIDLPVVDWKFEPDIRKKrllnYSIDFGICIFCGNCVEYCPTNC 118
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKT----VVIDPERCVGCGACVAVCPTGA 51
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
46-120 1.56e-08

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 52.72  E-value: 1.56e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2453163199  46 KLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKFEPdirkkrllnysIDFGICIFCGNCVEYCPTNCLS 120
Cdd:COG4624    75 GIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDGKAE-----------IDEEKCISCGQCVAVCPFGAIT 138
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 56-120 2.08e-08

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 48.51  E-value: 2.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2453163199  56 RIHFEFDKCIACEVCVRVCPID-LPVVDWKFEpdirkkrllnysIDFGICIFCGNCVEYCPTNCLS 120
Cdd:COG2221     9 PPKIDEEKCIGCGLCVAVCPTGaISLDDGKLV------------IDEEKCIGCGACIRVCPTGAIK 62
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 62-124 5.68e-08

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 47.73  E-value: 5.68e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2453163199  62 DKCIACEVCVRVCPIDLpvvdwkFEPDIRKkrllnYSIDFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:COG4231    22 DKCTGCGACVKVCPADA------IEEGDGK-----AVIDPDLCIGCGSCVQVCPVDAIKLEKR 73
PRK09898 PRK09898
ferredoxin-like protein;
48-129 6.07e-08

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 50.22  E-value: 6.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  48 ITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDwkfePDIRKKrllnysidfGICIFCGNCVEYCPTNCLSMTEEYEL 127
Cdd:PRK09898  140 ITWQQKEGCITVDHKRCIGCSACTTACPWMMATVN----TESKKS---------SKCVLCGECANACPTGALKIIEWKDI 206


                  ..
gi 2453163199 128 ST 129
Cdd:PRK09898  207 TV 208
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 63-124 1.22e-07

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 50.00  E-value: 1.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  63 KCIACEVCVRVCPIDLPVVDWKFEPDIRKKRLLNYSIDF--GICIFCGNCVEYCPTNCLSMTEE 124
Cdd:PRK14028  248 KCIMCRKCWLYCPDDAIIEAWREAEGPRGRKFRMKMIDFdyQYCKGCGVCAEVCPTGAIQMVRE 311
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
58-121 2.55e-07

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 49.09  E-value: 2.55e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  58 HFEFDKCIACEVCVRVCPIDLPVVDWKFEPdirkkrllnySIDFGICIFCGNCVEYCPTNCLSM 121
Cdd:COG1148   492 EVDPEKCTGCGRCVEVCPYGAISIDEKGVA----------EVNPALCKGCGTCAAACPSGAISL 545
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 48-120 3.19e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 46.80  E-value: 3.19e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2453163199  48 ITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWkfepdIRKKRLlnysidfgICIFCGN---CVEYCPTNCLS 120
Cdd:cd10550    66 ISRDEETGAVVVDEDKCIGCGMCVEACPFGAIRVDP-----ETGKAI--------KCDLCGGdpaCVKVCPTGALE 128
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
64-124 7.30e-07

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 47.62  E-value: 7.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2453163199  64 CIACEVCVRVCPIDLPVVDwKFEPdirkkrllnySIDFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:PRK07118  215 CIGCGKCVKACPAGAITME-NNLA----------VIDQEKCTSCGKCVEKCPTKAIRILNK 264
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 55-119 8.73e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 45.84  E-value: 8.73e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDLPVVDWKfEPDIRKkrllnysidfgiCIFCGN---------CVEYCPTNCL 119
Cdd:cd04410    73 GIVLIDEDKCIGCGSCVEACPYGAIVFDPE-PGKAVK------------CDLCGDrldeglepaCVKACPTGAL 133
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
62-124 1.30e-06

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 44.94  E-value: 1.30e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2453163199  62 DKCIACEVCVRVCPidlpvvdwkfEPDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:PRK09623   51 SKCVKCYICWKFCP----------EPAIYIKEDGYVAIDYDYCKGCGICANECPTKAITMVKE 103
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 55-133 1.90e-06

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 45.84  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDLPvvdwKFEPDIRK--KrllnysidfgiCIFCGN---------CVEYCPTNCLSMTE 123
Cdd:cd10558    94 GIVDFQSDKCIGCGYCIKGCPFDIP----RISKDDNKmyK-----------CTLCSDrvsvglepaCVKTCPTGALHFGT 158

                          90
                  ....*....|
gi 2453163199 124 EYELSTYDRH 133
Cdd:cd10558   159 KEDMLALAEK 168
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
51-124 2.22e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 44.65  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  51 ERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKFEPDIRKKrllnysidfgiCIFCGN------CVEYCPTNCLSMTEE 124
Cdd:COG1142    70 TRDDGAVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAVAVK-----------CDLCGGreggpaCVEACPTGALRLVDV 138
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 56-115 3.28e-06

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 42.62  E-value: 3.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2453163199  56 RIHFEFDKCIACEVCVRVCPIDLPVVdwkfepDIRKKRLLNYSIDFGI--CIFCGNCVEYCP 115
Cdd:pfam13237   1 KVVIDPDKCIGCGRCTAACPAGLTRV------GAIVERLEGEAVRIGVwkCIGCGACVEACP 56
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 64-121 5.65e-06

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 44.99  E-value: 5.65e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2453163199  64 CIACEVCVRVCPID--------LPVVDwkfePDIrkkrllnysidfgiCIFCGNCVEYCPTNCLSM 121
Cdd:COG2878   139 CIGCGDCIKACPFDaivgaakgMHTVD----EDK--------------CTGCGLCVEACPVDCIEM 186
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 62-124 9.77e-06

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 43.25  E-value: 9.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2453163199  62 DKCIACEVCVRVCPIDLPVVDWKFEPDIRKKrllnysidfgICIFCGNCVEYCPTNCLSMTEE 124
Cdd:TIGR01944 113 DNCIGCTKCIQACPVDAIVGAAKAMHTVIAD----------ECTGCDLCVEPCPTDCIEMIPV 165
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 62-126 9.97e-06

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 42.81  E-value: 9.97e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2453163199  62 DKCIACEVCvrvcpidlpvvdWKFEPDI----RKKRLLnySIDFGICIFCGNCVEYCPTN--CLSMTEEYE 126
Cdd:PRK09625   59 EICINCFNC------------WVYCPDAailsRDKKLK--GVDYSHCKGCGVCVEVCPTNpkSLLMFEEQI 115
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
 59-115 1.21e-05

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 43.58  E-value: 1.21e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2453163199  59 FEFDKCIACEVCVRVCPidlpVVDWK--------------FEPD----IRKKRLLNYSIDFGI--CIFCGNCVEYCP 115
Cdd:COG0479   139 DDLAECILCGACVAACP----NVWANpdflgpaalaqayrFALDprdeETEERLEALEDEEGVwrCTTCGNCTEVCP 211
Fer4_9 pfam13187
4Fe-4S dicluster domain;
63-119 1.92e-05

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 40.23  E-value: 1.92e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2453163199  63 KCIACEVCVRVCPIDLPVVDWKfepdirkKRLLNYSIDFGICIFCGNCVEYCPTNCL 119
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLV-------GQTIRGDIAGLACIGCGACVDACPRGAI 50
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 64-120 1.92e-05

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 41.47  E-value: 1.92e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2453163199  64 CIACEVCVRVCPIDLPVVDWKFEPDIRkkrllnysIDFGICIFCGNCVEYCPTNCLS 120
Cdd:TIGR00402  36 CTRCGECASACENNILQLGQQGQPTVE--------FDNAECDFCGKCAEACPTNAFH 84
PRK08493 PRK08493
NADH-quinone oxidoreductase subunit G;
55-120 2.66e-05

NADH-quinone oxidoreductase subunit G;


Pssm-ID: 236277 [Multi-domain]  Cd Length: 819  Bit Score: 43.16  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  55 GRIHFEFDKCIACEVCVRVC------------PIDLPVVDWKFEPDIRKKRL-----LNYSI------DFGICIFCGNCV 111
Cdd:PRK08493  134 GKINYDPSLCIVCERCVTVCkdkigesalktvPRGLDAPDKSFKESMPKDAYavwskKQKSLigpvggETLDCSFCGECI 213


                  ....*....
gi 2453163199 112 EYCPTNCLS 120
Cdd:PRK08493  214 AVCPVGALS 222
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 59-124 5.47e-05

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 40.40  E-value: 5.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2453163199  59 FEFDKCIACEVCVRVCPidlpvvdwkfEPDIRKKRlLNYSI-DFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:PRK09624   48 FNRDKCVRCYLCYIYCP----------EPAIYLDE-EGYPVfDYDYCKGCGICANECPTKAIEMVRE 103
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 60-156 6.07e-05

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 42.40  E-value: 6.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  60 EFDKCIACEVCVRVCPIDLPVVDWKFEPdirKKRLLNYSID-FGICIFCGNCVEYCPTNcLSMTEEYELSTYDRHELNYN 138
Cdd:cd01916   363 LAAKCTDCGWCTRACPNSLRIKEAMEAA---KEGDFSGLADlFDQCVGCGRCEQECPKE-IPIINMIEKAARERIKEEKG 438

                          90
                  ....*....|....*...
gi 2453163199 139 QIALGRLPmsvIDDYTIR 156
Cdd:cd01916   439 KMRAGRGP---IKDTEIR 453
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 63-117 8.90e-05

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 38.83  E-value: 8.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2453163199  63 KCIACEVCVRVCPIDL--------PVVDWKFEPDIRKKRLLNYSIDFGICIFCGNCVEYCPTN 117
Cdd:pfam13183   1 RCIRCGACLAACPVYLvtggrfpgDPRGGAAALLGRLEALEGLAEGLWLCTLCGACTEVCPVG 63
Fer4_18 pfam13746
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 64-132 1.12e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404610 [Multi-domain]  Cd Length: 114  Bit Score: 39.69  E-value: 1.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2453163199  64 CIACEVCVRVCPIDLpvvdwkfepDIRKKRLLNysidfgiCIFCGNCVEYCPTNCLSMTEEYELSTYDR 132
Cdd:pfam13746  61 CIDCESCVQVCPTGI---------DIRKGLQLE-------CINCGLCIDACNTIMGKLGKPRGLIRYSS 113
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 61-124 1.33e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 39.92  E-value: 1.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2453163199  61 FDKCIACEVCVRVCPID--------LPVVDwkfepdirkkrllnysIDFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:cd10564    12 LDLCTRCGDCVEACPEGiivrgdggFPELD----------------FSRGECTFCGACAEACPEGALDPARE 67
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
62-122 2.31e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 40.30  E-value: 2.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  62 DKCIACEVCVRVCPIDLPVvdwkFEPDIRKKRLLNYSIDFGI---------CIFCGNCVEYCPTNCLSMT 122
Cdd:PRK07118  168 DKCTGCGACVKACPRNVIE----LIPKSARVFVACNSKDKGKavkkvcevgCIGCGKCVKACPAGAITME 233
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 62-116 2.32e-04

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 39.89  E-value: 2.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2453163199  62 DKCIACEVCVRVCPIDLPVVDW-KFEPDIRKkrllnysidfgiCIFCGN---------CVEYCPT 116
Cdd:cd10561    99 DKCIGCRYCMVACPFNIPKYEWdSANPKIRK------------CTMCYDrlkegkqpaCVEACPT 151
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 55-119 2.41e-04

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 39.54  E-value: 2.41e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDLPVVDWKfepdiRKKrllnysidFGICIFCGN---------CVEYCPTNCL 119
Cdd:COG0437    83 GIVLVDYDKCIGCRYCVAACPYGAPRFNPE-----TGV--------VEKCTFCADrldegllpaCVEACPTGAL 143
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
55-116 2.58e-04

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 40.04  E-value: 2.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDLPVVDW-KFEPDIRKKRLLNYS----IDFGicifcGN--CVEYCPT 116
Cdd:PRK10882  136 GIVHYDKDVCTGCRYCMVACPFNVPKYDYnNPFGAIHKCELCNQKgverLDKG-----GLpgCVEVCPT 199
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
54-92 4.10e-04

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 37.40  E-value: 4.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2453163199  54 RGRIHFEFDKCIACEVCVRVCPIDLPVVDWKFEPDIRKK 92
Cdd:COG2768    32 DGKAVIDPEKCIGCGACIEVCPVGAIKIEWEEDEEFQEK 70
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 62-124 4.75e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 38.14  E-value: 4.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2453163199  62 DKCIACEVCVRVCPIDLPVVDWKFEPDIRKKRLLNYSIDF--GICIFCGN--CVEYCPTNCLSMTEE 124
Cdd:cd04410     6 DRCIGCGTCEVACKQEHGLRPGPDWSRIKVIEGGGLERAFlpVSCMHCEDppCVKACPTGAIYKDED 72
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 55-116 4.80e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 38.39  E-value: 4.80e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2453163199  55 GRIHFEFDKCIA------CEVCVRVCPIDLPVVdwKFEPDIRKKRllnysIDFGICIFCGNCVEYCPT 116
Cdd:cd16373    84 GVAVIDKDRCLAwqggtdCGVCVEACPTEAIAI--VLEDDVLRPV-----VDEDKCVGCGLCEYVCPV 144
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 97-120 5.25e-04

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 35.69  E-value: 5.25e-04
                          10        20
                  ....*....|....*....|....
gi 2453163199  97 YSIDFGICIFCGNCVEYCPTNCLS 120
Cdd:pfam00037   1 VVIDEEKCIGCGACVEVCPVGAIT 24
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 55-121 5.36e-04

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 38.39  E-value: 5.36e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCP---IDLPVVDWKFEPDIRKKRLLNYSIDfgICIFCGN---CVEYCPTNCLSM 121
Cdd:cd10554    78 GVVQVDEERCIGCKLCVLACPfgaIEMAPTTVPGVDWERGPRAVAVKCD--LCAGREGgpaCVEACPTKALTL 148
psaC CHL00065
photosystem I subunit VII
 61-120 5.92e-04

photosystem I subunit VII


Pssm-ID: 177005 [Multi-domain]  Cd Length: 81  Bit Score: 37.05  E-value: 5.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2453163199  61 FDKCIACEVCVRVCPID-LPVVDWkfepDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLS 120
Cdd:CHL00065    8 YDTCIGCTQCVRACPTDvLEMIPW----DGCKAKQIASAPRTEDCVGCKRCESACPTDFLS 64
NapF COG1145
Ferredoxin [Energy production and conversion];
62-124 6.59e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 38.94  E-value: 6.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2453163199  62 DKCIACEVCVRVCPIDLPVVDWKFEPDIRKKRLLN----YSIDFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:COG1145   138 ALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIkkakAVIDAEKCIGCGLCVKVCPTGAIRLKDG 204
PRK13795 PRK13795
hypothetical protein; Provisional
 63-115 6.98e-04

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 39.21  E-value: 6.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  63 KCIACEVCVRVCPIDLpvvdwkfepdIRKK-RLLNYSIDFGICIFCGNCVEYCP 115
Cdd:PRK13795  582 ECVGCGVCVGACPTGA----------IRIEeGKRKISVDEEKCIHCGKCTEVCP 625
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 99-124 7.88e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 36.18  E-value: 7.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 2453163199  99 IDFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:COG2221    12 IDEEKCIGCGLCVAVCPTGAISLDDG 37
PLN00071 PLN00071
photosystem I subunit VII; Provisional
 61-121 8.21e-04

photosystem I subunit VII; Provisional


Pssm-ID: 177700 [Multi-domain]  Cd Length: 81  Bit Score: 36.46  E-value: 8.21e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2453163199  61 FDKCIACEVCVRVCPID-LPVVDWkfepDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSM 121
Cdd:PLN00071    8 YDTCIGCTQCVRACPTDvLEMIPW----DGCKAKQIASAPRTEDCVGCKRCESACPTDFLSV 65
dhsB TIGR00384
succinate dehydrogenase and fumarate reductase iron-sulfur protein; Succinate dehydrogenase ...
 60-117 8.37e-04

succinate dehydrogenase and fumarate reductase iron-sulfur protein; Succinate dehydrogenase and fumarate reductase are reverse directions of the same enzymatic interconversion, succinate + FAD+ = fumarate + FADH2 (EC 1.3.11.1). In E. coli, the forward and reverse reactions are catalyzed by distinct complexes: fumarate reductase operates under anaerobic conditions and succinate dehydrogenase operates under aerobic conditions. This model also describes a region of the B subunit of a cytosolic archaeal fumarate reductase. [Energy metabolism, Aerobic, Energy metabolism, Anaerobic, Energy metabolism, TCA cycle]


Pssm-ID: 273049 [Multi-domain]  Cd Length: 220  Bit Score: 38.18  E-value: 8.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  60 EFDKCIACEVCVRVCPIDLPVVDW----------KFEPDIR----KKRLLNYSIDFGI--CIFCGNCVEYCPTN 117
Cdd:TIGR00384 136 QLSGCILCGCCYSSCPAFWWNPEFlgpaaltaayRFLIDSRdhatKDRLEGLNDKNGVwrCTTCMNCSEVCPKG 209
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 62-118 9.46e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 38.44  E-value: 9.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  62 DKCIACEVCVRVCPID----------LPVVDWKFEPDIRKK-------------------RLLNYSIDFGICIFCGNCVE 112
Cdd:COG2878   167 DKCTGCGLCVEACPVDciemvpvsptVVVSSWDKGKAVRKVvgciglcckkccpaaaitvNNLAAIIDYKKCTCCGCCEK 246


                  ....*.
gi 2453163199 113 YCPTNC 118
Cdd:COG2878   247 CCPTAI 252
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
64-117 1.05e-03

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 35.93  E-value: 1.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2453163199  64 CIACEVCVRVCP---IDLPVVDW--------------KFEPDIRKKRLLNYsidfgiCIFCGNCVEYCPTN 117
Cdd:pfam13484   1 CGSCGKCIDACPtgaIVGPEGVLdarrcisyltiekkGLIPDELRCLLGNR------CYGCDICQDVCPWN 65
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 99-124 1.57e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 35.47  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|....*.
gi 2453163199  99 IDFGICIFCGNCVEYCPTNCLSMTEE 124
Cdd:COG1149     8 IDEEKCIGCGLCVEVCPEGAIKLDDG 33
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 62-116 1.91e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 36.54  E-value: 1.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2453163199  62 DKCIACEVCVRVCPidlpvVDWKFEPDIRKKRL----LNYSIDFGICIFCGNCVEYCPT 116
Cdd:cd16372     8 EKCIGCLQCEEACS-----KTFFKEEDREKSCIriteTEGGYAINVCNQCGECIDVCPT 61
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 62-123 2.99e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 35.77  E-value: 2.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2453163199  62 DKCIACEVCVRVCPIDLPVvdwkFEPDirkkrllnYSIDFGiCIFCGNCVEYCPTNCLSMTE 123
Cdd:cd16372    77 KLCVGCLMCVGFCPEGAMF----KHED--------YPEPFK-CIACGICVKACPTGALELVE 125
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 55-119 3.23e-03

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 36.13  E-value: 3.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDLPVVDwKFEPDIRKkrllnysidfgiCIFCGN---------CVEYCPTNCL 119
Cdd:cd10562    93 GAVVVDEDKCIGCGYCVAACPFDVPRYD-ETTNKITK------------CTLCFDriengmqpaCVKTCPTGAL 153
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 62-118 3.39e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 36.76  E-value: 3.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  62 DKCIACEVCVRVCP---IDLpvVDWKfePDIRKKrllnysidfgiCIFCGNCVEYCPTNC 118
Cdd:NF038196  185 DKCIGCGICAKVCPvnnIEM--EDGK--PVWGHN-----------CTHCLACIHRCPKEA 229
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 55-128 3.72e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 35.71  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDLPVVDwKFEPDIRKkrllnysidfgiCIFCGN---------CVEYCPTNCLSMTEEY 125
Cdd:cd16374    66 GAVLVDPDKCIGCGMCAMACPFGVPRFD-PSLKVAVK------------CDLCIDrrregklpaCVEACPTGALKFGDIE 132


                  ...
gi 2453163199 126 ELS 128
Cdd:cd16374   133 ELL 135
mauM_napG TIGR00397
MauM/NapG family ferredoxin-type protein; MauM is involved in methylamine utilization. NapG is ...
 63-114 3.77e-03

MauM/NapG family ferredoxin-type protein; MauM is involved in methylamine utilization. NapG is associated with nitrate reductase activity. The two proteins are highly similar. [Energy metabolism, Electron transport]


Pssm-ID: 129492 [Multi-domain]  Cd Length: 213  Bit Score: 36.43  E-value: 3.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2453163199  63 KCIACEVCVRVCPIDLPVVDWKfEPDIRKKRLLNYSIDFGICIFCGNCVEYC 114
Cdd:TIGR00397 137 KGLNCSICVRVCPIRGEAISLK-PIENERGRLQIPTVDSAKCTGCGTCEKHC 187
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 56-124 4.00e-03

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 36.40  E-value: 4.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2453163199  56 RIHFEfDKCIACEVCVRVCPIDLPVVDwkfEPDIRKKRLLNysidfgiCIFCGNCVEYCPTNCLSMTEE 124
Cdd:PRK00783  164 RIEVS-EDCDECEKCVEACPRGVLELK---EGKLVVTDLLN-------CSLCKLCERACPGKAIRVSDD 221
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 63-120 4.41e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 35.69  E-value: 4.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2453163199  63 KCIACEVCVRVCP---IDLPVVDWKFEPdIRKKRlLNYSIDFgiCIFCGN-CVEYCPTNCLS 120
Cdd:cd16373    15 LCIRCGLCVEACPtgvIQPAGLEDGLEG-GRTPY-LDPREGP--CDLCCDaCVEVCPTGALR 72
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 55-119 4.70e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 35.84  E-value: 4.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2453163199  55 GRIHFEFDKCIACEVCVRVCPIDLPVVDWKFePDIRKkrllnysidfgiCIFC------GN---CVEYCPTNCL 119
Cdd:cd16366    93 GTVVVDPETCIGCGYCVNACPFDIPRFDEET-GRVAK------------CTLCydrisnGLqpaCVKTCPTGAL 153
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 62-126 5.96e-03

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 34.70  E-value: 5.96e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2453163199  62 DKCIACEVCVRVCPIDlpVVDWKFEPdirkKRLLNYSIDF---GICIFCGNCVEYCPTNCLSMTEEYE 126
Cdd:PRK09626   16 SRCKACDICVSVCPAG--VLAMRIDP----HAVLGKMIKVvhpESCIGCRECELHCPDFAIYVADRKE 77
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 64-125 7.41e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 34.62  E-value: 7.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2453163199  64 CIACEVCVRVCPidlpvvdwkFEPDIRKKRLLnYSIDFGICIFCGNCVEYCPTNCLSMTEEY 125
Cdd:cd16372    49 CNQCGECIDVCP---------TGAITRDANGV-VMINKKLCVGCLMCVGFCPEGAMFKHEDY 100
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
64-122 8.68e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 35.68  E-value: 8.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2453163199  64 CIACEVCVRVCPID-------LPVVDwkfepdiRKKrllnysidfgiCIFCGNCVEYCPTNCLSMT 122
Cdd:PRK07118  141 CLGLGSCVAACPFDaihiengLPVVD-------EDK-----------CTGCGACVKACPRNVIELI 188
PRK09326 PRK09326
F420H2 dehydrogenase subunit F; Provisional
 60-115 9.83e-03

F420H2 dehydrogenase subunit F; Provisional


Pssm-ID: 181779 [Multi-domain]  Cd Length: 341  Bit Score: 35.59  E-value: 9.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2453163199  60 EFDKCIACEVCVRVCPIDLPVVDWKFE-PDIRKKRLLNYSIDFGICIFCGNCVEYCP 115
Cdd:PRK09326   10 EYDVCTACGACEAVCPIGAITVDKKAEiRDPNDLELYEKGAAPNVCEGCLTCSRICP 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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