|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
7-361 |
2.76e-114 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 338.22 E-value: 2.76e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 7 LPLEDAL-RILAAafpppatpEIRADRDDPALDLSSMDGAALRSQD--GAAPR--RVLGTLFAGDdPAAFRVEPGTCVRI 81
Cdd:COG0303 23 VPLAEALgRVLAE--------DVVAPRDVPPFDNSAMDGYAVRAADlaGANPVtlRVVGEIAAGS-PPPGPLGPGEAVRI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 82 MTGAALPPGADAVVPVEDLVQGPQGLTPAAPPLPGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPTPP-LARL 160
Cdd:COG0303 94 MTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLASLGIAEVPvYRRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 161 RVGIVPTGDEITAH---PAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLL-GLGDLQILLTSGGVSAGDK 236
Cdd:COG0303 174 RVAILSTGDELVEPgepLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALReALAEADLVITSGGVSVGDY 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 237 DHLPRVLEAMGARILFHRIRLKPGKPMLTALLDGRVILGLPGNPVSSYMNALLFLPVAMAGLQGRRAPDPWK-EGRLAAA 315
Cdd:COG0303 254 DLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPPPPPPRvRARLAED 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2490892948 316 VPNPGDRPLLHPCRREGRD----LHPLPSQGSADLVRLAQADAFAWVPEG 361
Cdd:COG0303 334 LPKKPGRTEFLRVRLERDDgelvVEPLGGQGSGLLSSLAEADGLIVLPEG 383
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
7-362 |
1.04e-112 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 334.08 E-value: 1.04e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 7 LPLEDAL-RILAAafpppatpEIRADRDDPALDLSSMDGAALRSQD---GAAPRRVLGTLFAGDDPAaFRVEPGTCVRIM 82
Cdd:cd00887 20 VPLLEALgRVLAE--------DVVAPIDLPPFDNSAMDGYAVRAADtagASVTLRVVGEIPAGEPPD-GPLGPGEAVRIM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 83 TGAALPPGADAVVPVEDLVQGPQGLTPAAPPLPGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPTPP-LARLR 161
Cdd:cd00887 91 TGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIAEVPvYRRPR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 162 VGIVPTGDEITAH---PAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRD-FLLGLGDLQILLTSGGVSAGDKD 237
Cdd:cd00887 171 VAIISTGDELVEPgepLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREaLEEALEEADVVITSGGVSVGDYD 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 238 HLPRVLEAMGARILFHRIRLKPGKPMLTALLDGRVILGLPGNPVSSYMNALLFLPVAMAGLQGRRAPDP-WKEGRLAAAV 316
Cdd:cd00887 251 FVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPpRVKARLAEDL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2490892948 317 PNPGDRPLLHPCRREGRD----LHPLPSQGSADLVRLAQADAFAWVPEGG 362
Cdd:cd00887 331 KSKPGRREFLRVRLERDEgglvVAPPGGQGSGLLSSLARADGLIVIPEGV 380
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
7-360 |
4.90e-69 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 228.17 E-value: 4.90e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 7 LPLEDAL-RILAAAfpppatpeIRADRDDPALDLSSMDGAALRSQD--GA---APRR--VLGTLFAGDDPAaFRVEPGTC 78
Cdd:PRK14498 33 VPLEEALgRVLAED--------VYAPIDVPPFDRSAMDGYAVRAADtfGAseaNPVRlkLGGEVHAGEAPD-VEVEPGEA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 79 VRIMTGAALPPGADAVVPVEDLVQGPQG----LTPAAPplpGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPT 154
Cdd:PRK14498 104 VEIATGAPIPRGADAVVMVEDTEEVDDDtveiYRPVAP---GENVRPAGEDIVAGELILPKGTRLTPRDIGALAAGGVAE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 155 -PPLARLRVGIVPTGDEITAH---PAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLL-GLGDLQILLTSG 229
Cdd:PRK14498 181 vPVYKKPRVGIISTGDELVEPgepLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELEAALRkALKECDLVLLSG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 230 GVSAGDKDHLPRVLEAMGaRILFHRIRLKPGKPMLTALLDGRVILGLPGNPVSSYMNALLFLPVAMAGLQGRRAPDPWK- 308
Cdd:PRK14498 261 GTSAGAGDVTYRVIEELG-EVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPLLRKLAGLPPPERATv 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2490892948 309 EGRLAAAVPNPGDRPLLHP----CRREGRDLHPLpSQGSADLVRLAQADAFAWVPE 360
Cdd:PRK14498 340 KARLARRVRSELGREEFVPvslgRVGDGYVAYPL-SRGSGAITSLVRADGFIEIPA 394
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
27-151 |
2.00e-32 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 118.82 E-value: 2.00e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 27 EIRADRDDPALDLSSMDGAALRSQDGAAPRRVLGTlfAGDDPAAFRVEPGTCVRIMTGAALPPGADAVVPVED-LVQGPQ 105
Cdd:pfam03453 24 DVVAPRDVPPFDRSAMDGYAVRAADGFGASEVNPI--AAGEPPGPLLPGGEAVRIMTGAPLPEGADAVVMVEDtEEGGGR 101
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2490892948 106 GLTPAAPPLPGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVG 151
Cdd:pfam03453 102 TVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
163-285 |
5.33e-26 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 101.51 E-value: 5.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 163 GIVPTGDEITAhpaPHQIRDSNGPMLEALAHALGAEVRRLP--PLPDRPEAVRDFLLG-LGDLQILLTSGGVSAGDKDHL 239
Cdd:smart00852 1 AIISTGDELLS---GGQIRDSNGPMLAALLRELGIEVVRVVvvGGPDDPEAIREALREaLAEADVVITTGGTGPGPDDLT 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2490892948 240 PRVLEAMGAR-ILFHRIRLKPGKP-----MLTALLDG----RVILGLPGNPVSSYM 285
Cdd:smart00852 78 PEALAELGGReLLGHGVAMRPGGPpgplaNLSGTAPGvrgkKPVFGLPGNPVAALV 133
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
160-284 |
1.10e-25 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 100.85 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 160 LRVGIVPTGDEITA---HPAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLLGLGD-LQILLTSGGVSAGD 235
Cdd:TIGR00177 1 PRVAVISVGDELVEggqPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDeADVVLTTGGTGVGP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2490892948 236 KDHLPRVLEAMGARILFHR----------IRLKPGKPMLTALLDGRVILGLPGNPVSSY 284
Cdd:TIGR00177 81 RDVTPEALEELGEKEIPGFgefrmlsslpVLSRPGKPATAGVRGGTLIFNLPGNPVSAL 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
7-361 |
2.76e-114 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 338.22 E-value: 2.76e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 7 LPLEDAL-RILAAafpppatpEIRADRDDPALDLSSMDGAALRSQD--GAAPR--RVLGTLFAGDdPAAFRVEPGTCVRI 81
Cdd:COG0303 23 VPLAEALgRVLAE--------DVVAPRDVPPFDNSAMDGYAVRAADlaGANPVtlRVVGEIAAGS-PPPGPLGPGEAVRI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 82 MTGAALPPGADAVVPVEDLVQGPQGLTPAAPPLPGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPTPP-LARL 160
Cdd:COG0303 94 MTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLASLGIAEVPvYRRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 161 RVGIVPTGDEITAH---PAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLL-GLGDLQILLTSGGVSAGDK 236
Cdd:COG0303 174 RVAILSTGDELVEPgepLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALReALAEADLVITSGGVSVGDY 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 237 DHLPRVLEAMGARILFHRIRLKPGKPMLTALLDGRVILGLPGNPVSSYMNALLFLPVAMAGLQGRRAPDPWK-EGRLAAA 315
Cdd:COG0303 254 DLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPPPPPPRvRARLAED 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2490892948 316 VPNPGDRPLLHPCRREGRD----LHPLPSQGSADLVRLAQADAFAWVPEG 361
Cdd:COG0303 334 LPKKPGRTEFLRVRLERDDgelvVEPLGGQGSGLLSSLAEADGLIVLPEG 383
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
7-362 |
1.04e-112 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 334.08 E-value: 1.04e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 7 LPLEDAL-RILAAafpppatpEIRADRDDPALDLSSMDGAALRSQD---GAAPRRVLGTLFAGDDPAaFRVEPGTCVRIM 82
Cdd:cd00887 20 VPLLEALgRVLAE--------DVVAPIDLPPFDNSAMDGYAVRAADtagASVTLRVVGEIPAGEPPD-GPLGPGEAVRIM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 83 TGAALPPGADAVVPVEDLVQGPQGLTPAAPPLPGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPTPP-LARLR 161
Cdd:cd00887 91 TGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIAEVPvYRRPR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 162 VGIVPTGDEITAH---PAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRD-FLLGLGDLQILLTSGGVSAGDKD 237
Cdd:cd00887 171 VAIISTGDELVEPgepLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREaLEEALEEADVVITSGGVSVGDYD 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 238 HLPRVLEAMGARILFHRIRLKPGKPMLTALLDGRVILGLPGNPVSSYMNALLFLPVAMAGLQGRRAPDP-WKEGRLAAAV 316
Cdd:cd00887 251 FVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPpRVKARLAEDL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2490892948 317 PNPGDRPLLHPCRREGRD----LHPLPSQGSADLVRLAQADAFAWVPEGG 362
Cdd:cd00887 331 KSKPGRREFLRVRLERDEgglvVAPPGGQGSGLLSSLARADGLIVIPEGV 380
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
7-360 |
4.90e-69 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 228.17 E-value: 4.90e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 7 LPLEDAL-RILAAAfpppatpeIRADRDDPALDLSSMDGAALRSQD--GA---APRR--VLGTLFAGDDPAaFRVEPGTC 78
Cdd:PRK14498 33 VPLEEALgRVLAED--------VYAPIDVPPFDRSAMDGYAVRAADtfGAseaNPVRlkLGGEVHAGEAPD-VEVEPGEA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 79 VRIMTGAALPPGADAVVPVEDLVQGPQG----LTPAAPplpGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPT 154
Cdd:PRK14498 104 VEIATGAPIPRGADAVVMVEDTEEVDDDtveiYRPVAP---GENVRPAGEDIVAGELILPKGTRLTPRDIGALAAGGVAE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 155 -PPLARLRVGIVPTGDEITAH---PAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLL-GLGDLQILLTSG 229
Cdd:PRK14498 181 vPVYKKPRVGIISTGDELVEPgepLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELEAALRkALKECDLVLLSG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 230 GVSAGDKDHLPRVLEAMGaRILFHRIRLKPGKPMLTALLDGRVILGLPGNPVSSYMNALLFLPVAMAGLQGRRAPDPWK- 308
Cdd:PRK14498 261 GTSAGAGDVTYRVIEELG-EVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPLLRKLAGLPPPERATv 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2490892948 309 EGRLAAAVPNPGDRPLLHP----CRREGRDLHPLpSQGSADLVRLAQADAFAWVPE 360
Cdd:PRK14498 340 KARLARRVRSELGREEFVPvslgRVGDGYVAYPL-SRGSGAITSLVRADGFIEIPA 394
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
40-301 |
1.58e-47 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 170.18 E-value: 1.58e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 40 SSMDGAALRSQD-GAAPRRVLGTLFAGDdPAAFRVEPGTCVRIMTGAALPPGADAVVPVEDLVQGPQGLTPAAPPLPGAH 118
Cdd:PRK14491 247 SAMDGYAFRSDDlEPESYTLVGEVLAGH-QYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQN 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 119 VRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPTPPL-ARLRVGIVPTGDEItAHP----APHQIRDSNGPMLEALAH 193
Cdd:PRK14491 326 VRLAGEDLAQGQVALAAGTRLSAPEQGLLASLGFAEVPVfRRPKVAVFSTGDEV-QAPgetlKPNCIYDSNRFTIKAMAK 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 194 ALGAEVRRLPPLPDRPEAVRDFLL-GLGDLQILLTSGGVSAGDKDHLPRVLEAMGaRILFHRIRLKPGKPMLTALLDGRV 272
Cdd:PRK14491 405 KLGCEVIDLGIIEDSEAALEATLEqAAAQADVVISSGGVSVGDADYIKTALAKLG-QIDFWRINMRPGRPLAFGQIGDSP 483
|
250 260
....*....|....*....|....*....
gi 2490892948 273 ILGLPGNPVSSYMNALLFLPVAMAGLQGR 301
Cdd:PRK14491 484 FFGLPGNPVAVMVSFLQFVEPALRKLAGE 512
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
4-317 |
1.43e-41 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 150.63 E-value: 1.43e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 4 APLLPLEDALRILAAAFPPPATPE---------------IRADRDDPALDLSSMDGAALRSQD--GAAPRRVLGTLFAGd 66
Cdd:PRK10680 5 AGLMSLETALTEMLSRVTPLTATEtlplvqcfgritasdIVSPLDVPGFDNSAMDGYAVRLADlaSGQPLPVAGKAFAG- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 67 dpAAFRVE--PGTCVRIMTGAALPPGADAVVPVEDLVQGPQGLTPAAPPLPGAHVRPRGSQARKGDLLLPPGAPAGAGHT 144
Cdd:PRK10680 84 --QPFHGEwpAGTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGTRLTTAEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 145 GLLAQVGLPTPPLAR-LRVGIVPTGDEITA--HP-APHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRD-FLLGL 219
Cdd:PRK10680 162 PVLASLGIAEVPVVRkVRVALFSTGDELQLpgQPlGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALRAaFIEAD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 220 GDLQILLTSGGVSAGDKDHLPRVLEAMGaRILFHRIRLKPGKPMLTALLDGRVILGLPGNPVSSYMNALLFLPVAMAGLQ 299
Cdd:PRK10680 242 SQADVVISSGGVSVGEADYTKTILEELG-EIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAKLS 320
|
330
....*....|....*...
gi 2490892948 300 GRRAPDPWKEGRLAAAVP 317
Cdd:PRK10680 321 GNTASGLPPRQRVRTASR 338
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
43-367 |
1.26e-37 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 140.05 E-value: 1.26e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 43 DGAALRSQDGAAPRRVLGTLFAGDDPAAFRVEP------------------GTCVRIMTGAALPPGADAVVPVEDLVQGP 104
Cdd:PRK14690 58 DAVALRSNPPQANSAVDGYGFAGAAPEGAQVLPliegraaagvpfsgrvpeGMALRILTGAALPEGVDTVVLEEDVAGDG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 105 QGLTPAAPPLPGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPTPPLAR-LRVGIVPTGDEITAHPA---PHQI 180
Cdd:PRK14690 138 HRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLALLSAVGLTRVSVRRpLRVAVLSTGDELVEPGAlaeVGQI 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 181 RDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFL-LGLGDLQILLTSGGVSAGDKDHLPRVLEAMGARILFhRIRLKP 259
Cdd:PRK14690 218 YDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLdRAAAEADVILTSGGASAGDEDHVSALLREAGAMQSW-RIALKP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 260 GKPMLTALLDGRVILGLPGNPVSSYMNALLFLPVAMAGLQGRRAPDPWKEGRLAAAVPN--PGDRPLLHPCRREGRdLHP 337
Cdd:PRK14690 297 GRPLALGLWQGVPVFGLPGNPVAALVCTLVFARPAMSLLAGEGWSEPQGFTVPAAFEKRkkPGRREYLRARLRQGH-AEV 375
|
330 340 350
....*....|....*....|....*....|
gi 2490892948 338 LPSQGSADLVRLAQADAFAWVPEGGMGAGP 367
Cdd:PRK14690 376 FRSEGSGRISGLSWAEGLVELGDGARRIAP 405
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
27-326 |
1.36e-37 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 143.03 E-value: 1.36e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 27 EIRADRDDPALDLSSMDGAALRSQDGAAPRRVLGTLFAGDDPAAFRVEPGTCVRIMTGAALPPGADAVVPVED--LVQGP 104
Cdd:PLN02699 42 DIRAPDPLPPYPASVKDGYAVVASDGPGEYPVITESRAGNDGLGVTLTPGTVAYVTTGGPIPDGADAVVQVEDteVVEDP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 105 QG-------LTPAApplPGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGL------PTPPLArlrvgIVPTGDEI 171
Cdd:PLN02699 122 LDgskrvriLSQAS---KGQDIRPVGCDIEKDAKVLKAGERLGASEIGLLATVGVtmvkvyPRPTVA-----ILSTGDEL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 172 ----TAHPAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLLGL--GDLQILLTSGGVSAGDKDHLPRVLEA 245
Cdd:PLN02699 194 veptTGTLGRGQIRDSNRAMLLAAAIQQQCKVVDLGIARDDEEELERILDEAisSGVDILLTSGGVSMGDRDFVKPLLEK 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 246 MGaRILFHRIRLKPGKPMLTALLDGR---------VILGLPGNPVSSYMNALLFLPVAMAGLQGRRAPDPWK-EGRLAAA 315
Cdd:PLN02699 274 RG-TVYFSKVLMKPGKPLTFAEIDAKsapsnskkmLAFGLPGNPVSCLVCFNLFVVPAIRYLAGWSNPHLLRvQARLREP 352
|
330
....*....|.
gi 2490892948 316 VPNPGDRPLLH 326
Cdd:PLN02699 353 IKLDPVRPEFH 363
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
27-285 |
4.73e-34 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 132.24 E-value: 4.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 27 EIRADRDDPALDLSSMDGAALRSQDGAAPRRVLGTLFAGDdPAAFRVEPGTCVRIMTGAALPPGADAVVPVED--LVQGP 104
Cdd:PRK14497 46 DLMSPIDYPPFSRSTVDGYALKSSCTPGEFKVIDKIGIGE-FKEIHIKECEAVEVDTGSMIPMGADAVIKVENtkVINGN 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 105 QGLTPAAPPLpGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVGLPTPPL-ARLRVGIVPTGDEITaHPA----PHQ 179
Cdd:PRK14497 125 FIKIDKKINF-GQNIGWIGSDIPKGSIILRKGEVISHEKIGLLASLGISSVKVyEKPKIYLIATGDELV-EPGnslsPGK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 180 IRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLL-GLGDLQILLTSGGVSAGDKDHLPRVLEAMGaRILFHRIRLK 258
Cdd:PRK14497 203 IYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIKrAISVADVLILTGGTSAGEKDFVHQAIRELG-NIIVHGLKIK 281
|
250 260
....*....|....*....|....*..
gi 2490892948 259 PGKPMLTALLDGRVILGLPGNPVSSYM 285
Cdd:PRK14497 282 PGKPTILGIVDGKPVIGLPGNIVSTMV 308
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
27-151 |
2.00e-32 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 118.82 E-value: 2.00e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 27 EIRADRDDPALDLSSMDGAALRSQDGAAPRRVLGTlfAGDDPAAFRVEPGTCVRIMTGAALPPGADAVVPVED-LVQGPQ 105
Cdd:pfam03453 24 DVVAPRDVPPFDRSAMDGYAVRAADGFGASEVNPI--AAGEPPGPLLPGGEAVRIMTGAPLPEGADAVVMVEDtEEGGGR 101
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2490892948 106 GLTPAAPPLPGAHVRPRGSQARKGDLLLPPGAPAGAGHTGLLAQVG 151
Cdd:pfam03453 102 TVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
163-291 |
7.92e-27 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 103.87 E-value: 7.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 163 GIVPTGDEItahpAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRD-FLLGLGDLQILLTSGGVSAGDKDHLPR 241
Cdd:pfam00994 1 AIITTGDEL----LPGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEaLRAAAEEADVVITTGGTGPGPDDVTPE 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2490892948 242 VLEAMGAR------ILFHRIRLKPGKPMLTA-----LLDGRVILGLPGNPVSSYMNALLFL 291
Cdd:pfam00994 77 ALAELGGRelpgfeELFRGVSLKPGKPVGTApgailSRAGKTVFGLPGSPVAAKVMFELLL 137
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
163-285 |
5.33e-26 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 101.51 E-value: 5.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 163 GIVPTGDEITAhpaPHQIRDSNGPMLEALAHALGAEVRRLP--PLPDRPEAVRDFLLG-LGDLQILLTSGGVSAGDKDHL 239
Cdd:smart00852 1 AIISTGDELLS---GGQIRDSNGPMLAALLRELGIEVVRVVvvGGPDDPEAIREALREaLAEADVVITTGGTGPGPDDLT 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2490892948 240 PRVLEAMGAR-ILFHRIRLKPGKP-----MLTALLDG----RVILGLPGNPVSSYM 285
Cdd:smart00852 78 PEALAELGGReLLGHGVAMRPGGPpgplaNLSGTAPGvrgkKPVFGLPGNPVAALV 133
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
160-284 |
1.10e-25 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 100.85 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 160 LRVGIVPTGDEITA---HPAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLLGLGD-LQILLTSGGVSAGD 235
Cdd:TIGR00177 1 PRVAVISVGDELVEggqPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDeADVVLTTGGTGVGP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2490892948 236 KDHLPRVLEAMGARILFHR----------IRLKPGKPMLTALLDGRVILGLPGNPVSSY 284
Cdd:TIGR00177 81 RDVTPEALEELGEKEIPGFgefrmlsslpVLSRPGKPATAGVRGGTLIFNLPGNPVSAL 139
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
161-282 |
3.61e-19 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 82.78 E-value: 3.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 161 RVGIVPTGDEITAHpaphQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLLGLGD-LQILLTSGGVSAGDKDHL 239
Cdd:cd00758 1 RVAIVTVSDELSQG----QIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASReADLVLTTGGTGVGRRDVT 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2490892948 240 PRVLEAMGARIL-FHRIRLKPGKPMLTALLDGRVILGLPGNPVS 282
Cdd:cd00758 77 PEALAELGEREAhGKGVALAPGSRTAFGIIGKVLIINLPGSPKS 120
|
|
| MoeA_like |
cd03522 |
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ... |
156-298 |
8.54e-09 |
|
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.
Pssm-ID: 239599 Cd Length: 312 Bit Score: 56.40 E-value: 8.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490892948 156 PLARLRVGIVPTGDEitahPAPHQIRDSNGPMLEALAHALGAEVRRLPPLPDRPEAVRDFLLGLGDL--QILLTSGGVSA 233
Cdd:cd03522 156 PFRPLRVGLIVTGSE----VYGGRIEDKFGPVLRARLAALGVELVEQVIVPHDEAAIAAAIAEALEAgaELLILTGGASV 231
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2490892948 234 GDKDHLPRVLEAMGARILFHRIRLKPGKPMLTALLDGRVILGLPGNPVSSYMNAL-LFLPVAMAGL 298
Cdd:cd03522 232 DPDDVTPAAIRAAGGEVIRYGMPVDPGNLLLLGYLGGVPVIGLPGCARSPKLNGFdLVLPRLLAGE 297
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
310-362 |
1.57e-04 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 39.52 E-value: 1.57e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 2490892948 310 GRLAAAVPNPGDRPLLHPCRREGRD----LHPLPSQGSADLVRLAQADAFAWVPEGG 362
Cdd:pfam03454 2 ARLARDLKSDPGRREFVRVRLHEEDgryyAEPIGKQGSGMLSSLAEANGLIVVPEGT 58
|
|
| |
