|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-384 |
3.45e-79 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 248.66 E-value: 3.45e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 17 TLINFLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFY 96
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 97 TPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALI 176
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 177 ILCGIGSVIMKFNEPKLDiDSEEHKGIKISDYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKDLNLILAGtFFFVVYAV 256
Cdd:cd17489 161 LLALLLVFLVKDPPPVAA-EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAG-LFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 257 VITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVAT 336
Cdd:cd17489 239 ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1862189229 337 STYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-385 |
5.18e-38 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 141.17 E-value: 5.18e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 17 TLINFLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFY 96
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 97 TPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALI 176
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 177 ILCGIGSVIMKFNEPKLDIDSEEHKGIKISDYIEPRMNS----ISLVSILVGFAYSGVIGFMAAYTKDLNLILAGT--FF 250
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRrllaLFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQigLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 251 FVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVH 330
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1862189229 331 RIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFLY 385
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-346 |
1.27e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 123.16 E-value: 1.27e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 1 MDKAKEALWTRSFVLdTLINFLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKML 80
Cdd:COG2814 1 MPATPRRRWLALLAL-ALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 81 YLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILML 160
Cdd:COG2814 79 LLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 161 HSLGYDFIIAFCVALIILCGIGsVIMKFNEPKLDIDSEEHKGIKISdYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKD 240
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLL-LLRLLPESRPAARARLRGSLREL-LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 241 LNLILAGT--FFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSN 318
Cdd:COG2814 237 VLGLSASAagLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPL 316
|
330 340
....*....|....*....|....*...
gi 1862189229 319 GQAVTVKIVPVHRIGVATSTYFIALDMG 346
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-351 |
2.07e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 114.05 E-value: 2.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 18 LINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYT 97
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 98 PNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALII 177
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 178 LCGIGSVIMKFNEPKLDIDSEEHKGIKISDYIE----PRMNSISLVSILVGFAYSGVIGFMAAYTKDLNL-ILAGTFFFV 252
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKallrDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLsALLAGLLLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 253 VYAVVITITRPLLGIVFDMKGENFVLYPCFISLAL---GIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPV 329
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322
|
330 340
....*....|....*....|..
gi 1862189229 330 HRIGVATSTYFIALDMGLGFGP 351
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-392 |
2.47e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 106.50 E-value: 2.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 11 RSFVLDTLINFLVFLIYYLlIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLIS 90
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYL-WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 91 TAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIA 170
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 171 FCVALIILCGIGSVIMKFNEPKLDIDSEEHKGIKISDYI-EPRMNSISLVSILVGFAYSGVIGFMAAYTKD---LNLILA 246
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALrDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqfgLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 247 GTFFFVVYAVVItITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIA-HSTWLILLSAVFVGLGYGTFMSNGQAVTVK 325
Cdd:COG2223 244 GLLAALFALLGA-LGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1862189229 326 IVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVG-YTSMFHVTVVVALLAFVAYYFLYGRYVGTE 392
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-387 |
1.02e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 104.18 E-value: 1.02e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 21 FLVFLIYYLLIVIIAVVA---KDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYT 97
Cdd:COG2271 16 FLAYFLNYLDRSNLSVAApplQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 98 PNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALII 177
Cdd:COG2271 96 TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 178 LCGIGSVIMkfnepkldidseehkgikisdyieprmnsISLVSILVGFAYSGVIGFMAAY---TKDLNLILAGTFFFVVY 254
Cdd:COG2271 176 LLALLRFWL-----------------------------LALAYFLVYFALYGFLTWLPTYlveVRGLSLAQAGLLLSLPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 255 AVVItITRPLLGIVFD--MKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRI 332
Cdd:COG2271 227 LAGI-VGSLLGGWLSDrlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1862189229 333 GVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFLYGR 387
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-380 |
1.00e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 86.83 E-value: 1.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 21 FLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNL 100
Cdd:cd17324 9 FAIGTTEYVIQGLLPDIARD-FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 101 LMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYD--FIIAFCVALIIL 178
Cdd:cd17324 88 ALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRaaFLAIAVLALLAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 179 CGIGSV---IMKFNEPKLDIDSEEHKGIKisdyiEPRMNSISLVSILVGFAYSGVIGFMAAYTKDL--NLILAGTFFFVV 253
Cdd:cd17324 168 LLLWRLlpsLPPKKPGSLGLLSSLLLLLR-----NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpgFSSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 254 YAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRiG 333
Cdd:cd17324 243 FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-G 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1862189229 334 VATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17324 322 LASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-384 |
1.23e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 86.86 E-value: 1.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 18 LINFLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYT 97
Cdd:cd17474 6 FATLLAVLGVSIVDPILPAIAEA-LGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 98 PNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLG-ILMLHSLGYDFiiafcVALI 176
Cdd:cd17474 85 DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGgLLAAISWRYPF-----FLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 177 ILCGIGSVIMKFNEPKLDIDSEEHKGIKISDYIE----PRMNSISLVSILVGFAYSGVIGFM---AAYTKDLNLILAGTF 249
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKalrgRGLLTFLVSAFLYFFLYFAFLTYLpflLELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 250 FF---VVYAVVITITRPLLGIVFDMKgenFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKI 326
Cdd:cd17474 240 FAgwsVLLALGSLFVGRLLKKRFGAR---RILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1862189229 327 VPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-357 |
1.37e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 86.46 E-value: 1.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 21 FLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNL 100
Cdd:cd17321 6 FLAALDVTIVNVALPTIARD-LGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 101 LMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCG 180
Cdd:cd17321 85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 181 IGSvimkfnepkldidseehkgikisdyiePRMNSISLVSILVGFAYSGVIGFMAAY---TKDLNLILAGtFFFVVYAVV 257
Cdd:cd17321 165 LLA---------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYlqgVLGYSPLQAG-LALLPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 258 ITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHST---WLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGV 334
Cdd:cd17321 217 MLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADssvWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGA 296
|
330 340
....*....|....*....|...
gi 1862189229 335 ATSTYFIALDMGLGFGPYILGAI 357
Cdd:cd17321 297 ASGILNTARQLGGALGVALLGAL 319
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-387 |
1.65e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.45 E-value: 1.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 10 TRSFVLDTLINFLVFLIYYLLIVIIAVVaKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLI 89
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPAL-KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 90 STAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGeGINYYGLSTSLAAAVGPFLG-ILMLHSLGYDFI 168
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGgLLILLGLSLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 169 IAFCVALIILCGIGSVIMKFNEPKLDIDSEEHKGIKISdYIEPRMNSISLVSILVGFAYSGV----IGFMAAYTKDLNLI 244
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAAS-LKSLLKNPRLLLGGLAIFLYVGAegaiGDWLPLYLKDVLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 245 --LAGTFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAV 322
Cdd:COG0738 244 seATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1862189229 323 TVKIVPVHRiGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFhvTVVVALLAFVAYYFLYGR 387
Cdd:COG0738 324 ALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF--LVPLVCYLLILLLALALK 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-382 |
6.13e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 81.70 E-value: 6.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 17 TLINFLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFY 96
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 97 TPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDF--IIAFCVA 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWraVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 175 LIILCGIGSVIMKFNEPKLDI--DSEEHKGIKISDYIEPRMN----SISLVSILVGFAYSGVIGFMAAYTKDLNLILA-- 246
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARakNEEASSKSVLKLLKRVLKNpglwLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVav 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 247 GTFFFVVYAVVITITRPLLGIVFDMK-GENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVK 325
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1862189229 326 IVPVHRIGVATSTYFIALDMGLGFGPYILGAI-KEVVGYTSMFHVTVVVALLAFVAYY 382
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
10-387 |
1.42e-15 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 78.00 E-value: 1.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 10 TRSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLI 89
Cdd:PRK05122 14 TLRIVSIVMFTFISYLTIGLPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 90 STAMYFY--------TPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLH 161
Cdd:PRK05122 94 SGLLYLLagllaawpVLSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIGAPLGVLLYH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 162 SLGydfIIAFCVALIILCGIGSVIMKFNEPKLDIDSEEHKGIKISDYIEPRMNSISLVSIlvGFaysGVIG-FMAAYTKD 240
Cdd:PRK05122 174 WGG---LAGLGLLIMLLALLGLLLARPRPAVPPVKGERLPFRRVLGRVWPYGMGLALASI--GF---GTIAtFITLYYAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 241 LNLILAGtFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYG-TFMSNG 319
Cdd:PRK05122 246 RGWDGAA-LALTLFGVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSlVFPALG 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1862189229 320 qAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFLYGR 387
Cdd:PRK05122 325 -VEAVKRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALTWLLYRR 391
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
18-385 |
2.30e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 76.88 E-value: 2.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 18 LINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYT 97
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 98 PNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMlhsLGYDFIIAFCVALII 177
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL---LLYSFRLLFLAAAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 178 LCGIGSVIM-KFNEPKLDIDSEEHKGIKISDYIEPRMNS---ISLVSILVGFAYSGVIGFMAAYTKDLNLI---LAGTFF 250
Cdd:cd17329 163 FLLAALVLLfLLPETRPKRRAAEKTEILRGYKIVLRDRAfllFLLASFLISLIYFQLESTLPVYVVEILGLgesLLGLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 251 FVVYAVVITITRPLLGIVFDMKGEnFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVH 330
Cdd:cd17329 243 ALNALLIVLLQFPVARLVERFRLR-KILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPD 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1862189229 331 RIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFLY 385
Cdd:cd17329 322 KRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-380 |
7.07e-15 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 75.29 E-value: 7.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 18 LINFLVFLIYYLLIVIIAVVAKDNlHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYT 97
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 98 PNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLgyDFIIAFCVALII 177
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG--ALPFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 178 LCGIGSVIMKFNEPkldiDSEEHKGIKISDYIepRMNSISLVSILV-GFAYSGVIGFMAAYTKDLNL-ILAGTFFFVVYA 255
Cdd:cd17477 160 LALVPLLLTRRAAP----EIEEAESISLRRLL--RIAPLALLGAFVaGFLEGAFYSLLPLYGLRLGLsVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 256 VVITITRPLLGIVFDMKGENFVLYPC-FISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGV 334
Cdd:cd17477 234 LGGLLLQWPLGWLADRFDRRRVLLGCaLLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1862189229 335 ATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
42-380 |
6.51e-14 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 72.58 E-value: 6.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 42 LHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLG-LLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTA 120
Cdd:cd17370 29 LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILgYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 121 TSTIVAAIIPMSRRGEGinyYGLSTSL---AAAVGPFLGILMLHSLGYDFIIAFCVALII-LCGIGSVIMKFNEPKLDID 196
Cdd:cd17370 109 RDALLADATPPSGRGKA---FGLHRALdtlGAVLGPLLAALLLYLLGGNYRTIFLLAAIPaLLALLILLFVVKEYPRPPK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 197 SEEHKGIKISDYIEPRMNSISLVSILVGFAYSGViGFMAAYTKDLNL-ILAGTFFFVVYAVVITITRPLLGIVFDMKGEN 275
Cdd:cd17370 186 LRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSF-AFLILRAQELGLsAALIPLLYALFNLVYALAAYPAGRLSDRIGRK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 276 FVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILG 355
Cdd:cd17370 265 KLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAG 344
|
330 340
....*....|....*....|....*
gi 1862189229 356 AIKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17370 345 YLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-384 |
1.00e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.14 E-value: 1.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 44 ATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTATST 123
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 124 IVAAIIPMSRRGEGINYYGLSTSLAAAVGPFL-GILMLHSLGYDFIIaFCVALIILcgIGSVIMKFNEPKLDIDSEEHKG 202
Cdd:cd17473 112 LIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLgGALAEIGWRAPFLV-YLLALPVL--ILVLLFLPEPARKSKSAASPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 203 IKISDYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKDLNLILAGT--FFFVVYAVVITITRPLLGIVFDMKGENFVLYP 280
Cdd:cd17473 189 ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALigLALAIASLAGAIGALLFGRLKRRLGKRRLLAI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 281 CFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAI-KE 359
Cdd:cd17473 269 GFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLvNL 348
|
330 340
....*....|....*....|....*
gi 1862189229 360 VVGYTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
216-384 |
2.98e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 67.31 E-value: 2.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 216 ISLVSILVGFAYSGVIGFMAAYTKDLNL-ILAGTFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSI 294
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGAsPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 295 AHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVA 374
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
170
....*....|
gi 1862189229 375 LLAFVAYYFL 384
Cdd:COG2814 175 LLALLLLLRL 184
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
41-357 |
1.55e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 65.29 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 41 NLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTA 120
Cdd:cd17503 25 DLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 121 TSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIiaFCVALIIlcGIGSVIMKfnePKLDIDSEEH 200
Cdd:cd17503 105 AQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWI--FYINLPI--GILALLLA---PLLDLRLFKD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 201 KGIKISdyieprmnsiSLVSILVGFAYSGVIGFMAAYT---KDLNLILAGtFFFVVYAVVITITRPLLGIVFDMKGENFV 277
Cdd:cd17503 178 RNFTLG----------LLLSFLLGLGLFGAMFLLPLYLqnvLGYSAFESG-LVLAPGGLASAILSPLVGRLLDKFGPRLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 278 LYPCFISLALGIFLLSIAH---STWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYIL 354
Cdd:cd17503 247 LLAGLLLLALGTLLLAFLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALL 326
|
...
gi 1862189229 355 GAI 357
Cdd:cd17503 327 ATL 329
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
20-295 |
8.24e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.52 E-value: 8.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 20 NFLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPN 99
Cdd:COG0477 23 TFLEGLDFTIVNVALPSIAAD-LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 100 LLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILC 179
Cdd:COG0477 102 PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 180 GIGSVIMKFNEPKLDIDSEEHKGIKISDYIEPRMNSISLVSILVGFAYSGVIGFMAAYtkdLNLILAGTFFFVVYAVVIT 259
Cdd:COG0477 182 LVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL---LLLLALLLLALLLLLALLL 258
|
250 260 270
....*....|....*....|....*....|....*.
gi 1862189229 260 ITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIA 295
Cdd:COG0477 259 LAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-151 |
1.80e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 61.91 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 5 KEALWTRSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGL 84
Cdd:COG2814 201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1862189229 85 LIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAV 151
Cdd:COG2814 281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
21-387 |
2.57e-10 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 61.62 E-value: 2.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 21 FLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMY---FYT 97
Cdd:PRK12382 25 FLTYMTVGLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGLAYllaAIL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 98 P-----NLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFC 172
Cdd:PRK12382 105 PvsapfKFALLVVGRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHSHFGFAALALTT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 173 VALIILcgigSVIMKFNEPKLDIDSEEHkgikisdyiePRMNSI-------SLVSILVGFAYSGVIGFMAAYTKDLNLIL 245
Cdd:PRK12382 185 MVLPLL----AWAFNGTVRKVPAHAGER----------PSLWSVvgliwkpGLGLALQGVGFAVIGTFVSLYFASKGWAM 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 246 AGtFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYG-TFMSNGQAVtV 324
Cdd:PRK12382 251 AG-FTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSlIFPALGVEV-V 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1862189229 325 KIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFLYGR 387
Cdd:PRK12382 329 KRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSFRR 391
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-384 |
2.67e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.43 E-value: 2.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 21 FLVFLIYYLLIVIIAVVA---KDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYT 97
Cdd:cd17319 9 FLAYVINYLDRVNISVAAptiMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 98 PNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLG--YDFIIAFCVAL 175
Cdd:cd17319 89 TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGwrWAFIIEGLLGL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 176 IILCgigsvimkfnepkldidseehkgikISDYIEPRMNSISLVSILVGFAYSGVIGFMAAY---TKDLNLILAGtFFFV 252
Cdd:cd17319 169 LLAV-------------------------LWWFYLRQVWGLALGYFGINYALYGLLTWLPTYlkqARGFSLKQVG-LLAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 253 VYAVVITITRPLLGIVFDMKGENFVLYPCFISLAL---GIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPV 329
Cdd:cd17319 223 IPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLaavGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1862189229 330 HRIGVATSTYFIALDMGLGFGPYILGAIKEVVG-YTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17319 303 EAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
13-380 |
6.07e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 60.26 E-value: 6.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 13 FVLDTLINFLVFLIYYLliviiavvaKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTA 92
Cdd:cd17478 6 FLNDFYQGFLPALLPLL---------IAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 93 MYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPmSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFC 172
Cdd:cd17478 77 LLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 173 VALIILCGIgsVIMKFNEPKLDIDSEEHKGIKISDYIEPRMNSISLVSILV---GFAYSGVIGFMAAYTKDLNL-ILAGT 248
Cdd:cd17478 156 IIPGLAVAL--LLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVflrSWVLSSLTTFLPFYLVQRGYsLVFAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 249 FFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFmSNGQAVTVKIVP 328
Cdd:cd17478 234 LLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASF-PVTVVLAQELLP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1862189229 329 VHrIGVATStyfiaLDMGLGFG-----PYILGAIKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17478 313 GN-VGLASG-----LMMGLSFGlggigAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
216-384 |
7.11e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 60.12 E-value: 7.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 216 ISLVSILVGFAYSGVIGFMAAY-TKDLNLILAGT-FFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLS 293
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGISPTEIgLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 294 IAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVV 373
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|.
gi 1862189229 374 ALLAFVAYYFL 384
Cdd:pfam07690 161 SLLAAVLLLLP 171
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
34-380 |
7.16e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 60.33 E-value: 7.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 34 IAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFA 113
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 114 YGITSTATSTIVAAIIPMSRRG--EGINYYG--LSTSLAAAVGPFLgilmlhSLGYDFIIAFCVALIILCGIGSVIMKF- 188
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGlaMGIRQTGvpLGGALAAALLPPL------ALHYGWRAAFVVAGLVSILAAVLFWLFy 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 189 ---NEPKLDIDSEEHKGIKISDYI-EPRMNSISLVSILVGFAYSGVIGFMAAYTKD---LNLILAGTFFFVVYAVVItIT 261
Cdd:cd17475 172 repPAASAATESASTLLRSLKEVLrNRDVWLIAIAGALLVAPQFALLTFLLLFLHDhlgLSVVAAGALLAVAQLGGA-LG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 262 RPLLGIVFD-MKGENFVLYPCFISLALGIFLLSIA---HSTWLILLSAVFVGLGYGTFMSNGQAVT--VKIVPVHRIGVA 335
Cdd:cd17475 251 RIGLGRVSDrVFGGRRRPVLVITAAIAAAALLVLSllsPGTPLWLLVLLLILLGLFAIGWNGLYLTlvAESAGPEQAGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1862189229 336 TSTYFIALDMGLGFGPYILGAIKEVVG-YTSMFHVTVVVALLAFVA 380
Cdd:cd17475 331 LGLANTINFIGIAIGPPLFGLLVDATHsYAPAWLALALLLVLAALL 376
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
108-384 |
7.27e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 60.32 E-value: 7.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 108 FLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIGSVIMK 187
Cdd:cd06173 100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIR 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 188 FNEPKLDIDSEEHKGIKISDYIE-----PRMNSISLVSILVGFAYSGVIGFMAAYTKDLNLILAGTF--FFVVYAVVITI 260
Cdd:cd06173 180 RPPPAAPGESSSLLLRDLREGLRylrrsPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYglLLAAFGVGALL 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 261 TRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYF 340
Cdd:cd06173 260 GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1862189229 341 IALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
30-392 |
1.05e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 59.89 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 30 LIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFL 109
Cdd:COG2807 37 VGPLLPEIRAD-LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 110 NGFAYGITSTATSTIVAAIIPmSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIGSVIMKFN 189
Cdd:COG2807 116 IGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 190 EPKLDIDSEEHKGIKiSDYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKDLNL--ILAGTFFFVVYAVVItITRPLLGI 267
Cdd:COG2807 195 RPAAAAAAPAAASLR-SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLsaATAGLLLSLFQLAGI-PGSLLVPL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 268 VFD-MKGENFVLYPCFISLALGIFLLSIAhSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMG 346
Cdd:COG2807 273 LADrLGDRRPLLLLLGLLGLAGLLGLLLA-PGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYL 351
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1862189229 347 LG-FGPYILGAIKEVVG-YTSMFHVTVVVALLAFVAYYFLYGRYVGTE 392
Cdd:COG2807 352 LAaLGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLAGRPYVEDA 399
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-380 |
1.28e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.15 E-value: 1.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 13 FVLDTLINFLVFLIYYLLIVIIAVVAKD-NLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLIST 91
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 92 AMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFiiAF 171
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW--GW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 172 CVALIILCGIGSVIMkfnepkldidseehkgikisdYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKDLNLILAGT--F 249
Cdd:cd17316 159 RILFLIGALPALLAL---------------------LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATssL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 250 FFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAH--STWLILLSAVFVGLGYGTFMSNGQAVTVKIV 327
Cdd:cd17316 218 YLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLsgSPTLLLLLLFILSFFVGGVWGALYAYLAELF 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1862189229 328 PVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17316 298 PTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
216-389 |
2.23e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 2.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 216 ISLVSILVGFAYSGVIGFMAAYTKDLNL------ILAGTFFFVVyavviTITRPLLGIVFDMKGENFVLYPCFISLALGI 289
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGseavagLVVGLFTLAA-----LLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 290 FLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHV 369
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170 180
....*....|....*....|
gi 1862189229 370 TVVVALLAFVAYYFLYGRYV 389
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPP 175
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
17-383 |
2.53e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 58.49 E-value: 2.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 17 TLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFY 96
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 97 TPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPmSRRGEGINYYGLSTSLAAAVGPFLGILMLHSL---GYDFIIAFCV 173
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSElswSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 174 ALIILcgIGSVIMKFNEPKLDIDSEEHKGIKISDYIEPRMNSISLVSILVGFAYSG----VIGFM---AAYTKDLNLILA 246
Cdd:cd17333 160 YLLLA--ILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGaetaFSSWVpsyLVEKKHVSDGLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 247 GtFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKI 326
Cdd:cd17333 238 G-YLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISN 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1862189229 327 VPVHRiGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYF 383
Cdd:cd17333 317 LPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-187 |
4.94e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.57 E-value: 4.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 12 SFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILG--CRKMLYLGLLIYLI 89
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 90 STAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFII 169
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170
....*....|....*...
gi 1862189229 170 AFCVALIILCGIGSVIMK 187
Cdd:COG2271 341 LLLAALALLAALLALLLL 358
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-181 |
2.45e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 55.31 E-value: 2.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 17 TLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFY 96
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 97 TPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALI 176
Cdd:cd06173 294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALL 373
|
....*
gi 1862189229 177 ILCGI 181
Cdd:cd06173 374 LLAAL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-186 |
3.11e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 3.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 11 RSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLIS 90
Cdd:cd17329 200 RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 91 TAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIA 170
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL 359
|
170
....*....|....*.
gi 1862189229 171 FCVALIILCGIGSVIM 186
Cdd:cd17329 360 ILAALGLIAAALLLGL 375
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
18-385 |
3.55e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 54.92 E-value: 3.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 18 LINFLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLG-LLIYLISTAMYFY 96
Cdd:cd17490 3 IIVFLFWFSQYVYVPFLSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLASLIMIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 97 TPNLLMLDSVRFLNGFAYGITSTATSTIvAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYD--FIIAFCVA 174
Cdd:cd17490 82 FPSPWGLLIARFLSGIAAATWVSFTVLY-ASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRapFLLAALAG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 175 LIILCgigsVIMKFNEPKLDIDSEEHKGIKISDYI-EPRMNSISLVSILVGFA-YSGVIGFMAAYTKDLN-----LILAG 247
Cdd:cd17490 161 VLGFI----LSLFIKEERREKKPVLTELKELLSVLkDKKLLFFSLLAILQQMItFSTTFGFTPLIAKQLGassfqLGLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 248 TFFFVVYAVVITITRPLLGIVFdmkGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIV 327
Cdd:cd17490 237 IIYLLPNALASLLSGTLFYKKL---GERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGV 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1862189229 328 PVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFLY 385
Cdd:cd17490 314 PAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-380 |
1.74e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 52.97 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 29 LLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRF 108
Cdd:cd17504 14 MLSPALPTIQRE-FGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 109 LNGFAYGITSTATStIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIGSvimkf 188
Cdd:cd17504 93 LQGIGGAVFPLAFA-LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV----- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 189 nePKLDIDSEEHKGIKISdyieprmNSISLVSILVGFAYSGVIGFMAAYTKDLNLILAGTFFFVV---YAVVITITRPLL 265
Cdd:cd17504 167 --PLIDLRLLRRRNVLLA-------NITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLllpGALVMLIAGPLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 266 GIVFDMKGENFVLYPCFISLALGIFLLSIAHST-WLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALD 344
Cdd:cd17504 238 GRLIARVGPRRVLLIGLVISAVGLLLLALLHSSlWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRT 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 1862189229 345 MGLGFGPYILGAIkeVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17504 318 IGSAIGPAIAGAI--LTTYTVSITSGGVPTEGAYVL 351
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
253-384 |
2.39e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.55 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 253 VYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRI 332
Cdd:cd17324 42 AYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKR 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1862189229 333 GVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17324 122 GRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
4-187 |
2.95e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.19 E-value: 2.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 4 AKEALWTRSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLG 83
Cdd:COG2223 198 QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 84 LLIYLISTAMYFYTP-NLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFL-GILMLH 161
Cdd:COG2223 278 FALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLfGALLDA 357
|
170 180
....*....|....*....|....*.
gi 1862189229 162 SLGYDFIIAFCVALIILCGIGSVIMK 187
Cdd:COG2223 358 TGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
18-186 |
3.48e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.81 E-value: 3.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 18 LINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYT 97
Cdd:cd17473 204 FLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 98 PNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFL-GILMLHSLGYDFIIAFCVALI 176
Cdd:cd17473 284 SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlGPLVNLTGGLSGAFLILGVLA 363
|
170
....*....|
gi 1862189229 177 ILCGIGSVIM 186
Cdd:cd17473 364 LVLAIVLLLL 373
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
41-379 |
4.17e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.42 E-value: 4.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 41 NLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTA 120
Cdd:cd17330 28 KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 121 TSTIvAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIGSVImkfnepkldidseeh 200
Cdd:cd17330 108 QAYI-ADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLF--------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 201 kgikisdyIEPRMNSISLVSILVGFAYSGVIGFMAAYTKD---LNLILAGTFFFVVYAVVITITRPLLGIVFDMKGENFV 277
Cdd:cd17330 172 --------FLPPLRRLLLVYFLIALAFAGLESVFSLFLKDrfgFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 278 LYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAI 357
Cdd:cd17330 244 LRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL 323
|
330 340
....*....|....*....|..
gi 1862189229 358 KEVVGYTSMFHVTVVVALLAFV 379
Cdd:cd17330 324 YSFLGPGVPFLLAAGLLLIALF 345
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
17-379 |
4.83e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 4.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 17 TLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFY 96
Cdd:cd17472 2 SLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 97 TPNLLMLDSVRFLNGfaYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALI 176
Cdd:cd17472 82 ATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 177 ILCGIGSVIMKFNEPKLDIDSEEHKGIKISDYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKDLNLILAGTFFFVVYAV 256
Cdd:cd17472 160 LVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 257 VITITRPLLGIVFDMKGENF--VLYPCFISLALG-IFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIG 333
Cdd:cd17472 240 LIGFILMVPFVIYAEKKGKMkqVFVSSILLIAVGfLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1862189229 334 VATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFV 379
Cdd:cd17472 320 TAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
144-379 |
5.73e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.01 E-value: 5.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 144 STSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIGSVIMKFNEPKlDIDSEEHKGIKISDYIEPRMNSISLVSILV 223
Cdd:cd17471 133 AFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKP-PAQKATPASSLVKAPVNRRLLLLFAAFTLL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 224 GFAYSGVIGFMAAY-TKDLNL--ILAGTFFFVVYAVVITITrPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWL 300
Cdd:cd17471 212 FAANSMYIIAMPLYvTNELGGseSWVGLLFGLAAALEIPIM-LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQ 290
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1862189229 301 ILLSAVFVGLGYGTFMSNGQAVTVKIVPvHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFV 379
Cdd:cd17471 291 LIALQLLNAIFIGITAGLGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
222-410 |
7.71e-07 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 51.07 E-value: 7.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 222 LVGFAYSGVIGFMAAYTKDLN------LILAGTFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIA 295
Cdd:PRK09874 25 LTGAAFSLVMPFLPLYVEQLGvtghsaLNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 296 HSTWLILLSAVFVGLgYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVAL 375
Cdd:PRK09874 105 QNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLF 183
|
170 180 190
....*....|....*....|....*....|....*.
gi 1862189229 376 LAF-VAYYFLYGRYVGTEKDLSLKARAEEEQIRNRK 410
Cdd:PRK09874 184 LCFlVTLFCIRENFQPVSKKEMLHMREVVTSLKNPK 219
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-383 |
7.89e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.06 E-value: 7.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 20 NFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFI----SILGCRK-MLYLGLLIYLISTAMY 94
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRpWILIGAIPLALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 95 FYTPNLLMLDSV------RFLNGFAYGITSTATSTIVAAIIP-MSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDF 167
Cdd:COG2211 99 FTAPDLSPTGKLiyalvtYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 168 IIAF---CVALIILCGIGSVIMKFNEPKLDIDSEEHKGIKiSDYIEPRMNS----ISLVSILVGFAYSGVIGFMAAYTKD 240
Cdd:COG2211 179 ALGYrltALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLK-ESLKALLKNRpfllLLLAYLLFFLALALVAALLLYYFKY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 241 -LNLILA-GTFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALG--IFLLSIAHSTWLILLSAVFVGLGYGTFM 316
Cdd:COG2211 258 vLGLSAAlVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGllLLFFLGPGNLWLLLVLAALAGIGLGAIL 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 317 SNGQAVTVKIVPVHRI-------GVATSTYFIALDMGLGFGPYILGAIKEVVGYTS---------------MFHVTVVVA 374
Cdd:COG2211 338 VLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirllFFLLPAVLL 417
|
....*....
gi 1862189229 375 LLAFVAYYF 383
Cdd:COG2211 418 LLAALLLLF 426
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
39-379 |
1.02e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 50.49 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 39 KDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLlmldsvrFLNGFAYGITS 118
Cdd:cd17314 30 QDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNS-------FPLSYACFVFI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 119 TATSTIVAAIIPMSRRGEGINYYGLSTSLAAA---VGPFLGILMLHSL--------GYDFIIAFCVALIILCGIGSVIMK 187
Cdd:cd17314 103 GAGTGILYGSAVLVTTQYFPDTKGLALGLPTTgysLGLVLGSPLLRILwvfyglalVYTILGILAAIVLSVVSLLGFKEP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 188 FNEPKLDIDSEEHKGIKISDYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKDLNLILAG--TFFFVVYAVVITITRPLL 265
Cdd:cd17314 183 PDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSfvTKLMSIYGLFNAFGRLLW 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 266 GIVFDMKGENFVLYPC---FISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIA 342
Cdd:cd17314 263 GIVADFFGGRLSTLSIlltILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFA 342
|
330 340 350
....*....|....*....|....*....|....*...
gi 1862189229 343 LDMGLGFGPYILGAIKEVV-GYTSMFHVTVVVALLAFV 379
Cdd:cd17314 343 PAIGSILGPMLGAKFYDRTpSYISAVYIYAVIVFLASA 380
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
5-204 |
1.15e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 5 KEALWTRSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGL 84
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 85 LIYLISTAMYFYTP--NLLMLDSVRFLNGFAYGITSTATSTIVAAIIP-----MSRRGEGINY--YGLSTSLAAAVGPFL 155
Cdd:COG2211 302 LLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewkTGRRREGLYFgiFTFAIKLGQALAGAL 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1862189229 156 GILMLHSLGYD------------FIIAFCVALIILCGIGSVIMKFnepkLDIDSEEHKGIK 204
Cdd:COG2211 382 AGLLLALFGYVagaaqspsaltgIRLLFFLLPAVLLLLAALLLLF----YPLTRERHAEIR 438
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
5-178 |
1.42e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 5 KEALWTRSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISI-LGCRKMLYLG 83
Cdd:cd17474 192 KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 84 LLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSL 163
Cdd:cd17474 272 LLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
|
170
....*....|....*..
gi 1862189229 164 GYD--FIIAFCVALIIL 178
Cdd:cd17474 352 GLSapFLVGAAIALAAA 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
33-384 |
6.79e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.93 E-value: 6.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 33 IIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLD-SVRFLNG 111
Cdd:cd17352 24 VLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYlTYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 112 FAYGITSTATSTIVaaiipmsrrgegiNYY-----GLSTSLAAAVGPFLGILMLHSL-----GYDF-----IIAFCVALI 176
Cdd:cd17352 104 LGLGLIYSPAIVIV-------------GQYfekkrGLATGIAVAGSGVGTFVFPPLLrylldNYGWrgallILGGLCLNL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 177 ILCGIGSVIMKFnepkldidseehkgikisdyiepRMNSISLVSILVG-FAYSGVIGFMAAYTKDLNL-ILAGTFFFVVY 254
Cdd:cd17352 171 CVCGLLLRLLKD-----------------------PTFVLLALGVSFAmLGFFVPFVYLPSYAKSLGIdESDAAFLLSII 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 255 AVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLL--SIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRI 332
Cdd:cd17352 228 GISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLafPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKL 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1862189229 333 GVATSTYFIALDMGLGFGPYILGAIKEVVG-YTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17352 308 SNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
8-163 |
9.51e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.55 E-value: 9.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 8 LWTRSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIY 87
Cdd:cd17321 165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1862189229 88 LISTA-MYFYTPNLLMLDSV--RFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSL 163
Cdd:cd17321 245 AVGLLlLALLGADSSVWLLLpgLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
216-384 |
1.19e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.73 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 216 ISLVSILVGFAYSGVIGFMAAYTKDLNLILAGT-FFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSI 294
Cdd:COG0477 19 LALGTFLEGLDFTIVNVALPSIAADLGASSAQLgWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 295 AHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVA 374
Cdd:COG0477 99 APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG 178
|
170
....*....|
gi 1862189229 375 LLAFVAYYFL 384
Cdd:COG0477 179 LLALVLRLRL 188
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
39-380 |
1.48e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.87 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 39 KDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITS 118
Cdd:cd17393 26 KDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 119 TATSTIVAAIIPMSRRGEGINYYGLStSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIGSVIMKFNEPKLDIDSE 198
Cdd:cd17393 106 VAMNAQGVAVERAYGRPIMSSLHAMW-SLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEAAED 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 199 E--HKGIKISDYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKDLNLILA--GTFFFVVYAVVITITRPLLGIVFDMKGE 274
Cdd:cd17393 185 RpdGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAalAALGYAVFSLAMTVGRLFGDRLVDRFGD 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 275 NFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYG-----TFMSNGQAVTVKivPVHRIGVATSTYFIaldmGLGF 349
Cdd:cd17393 265 VAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSvvvplAFSAAGALPGLA--AGIAVARVATLGYL----GFLV 338
|
330 340 350
....*....|....*....|....*....|.
gi 1862189229 350 GPYILGAIKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17393 339 GPPLIGFLADATGLRTAFLVVALLALLVALL 369
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
240-385 |
2.16e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.40 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 240 DLNLILAGTFFFVvYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNG 319
Cdd:cd17478 27 GLSYAQAGLLVSV-FSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEG 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1862189229 320 qAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFLY 385
Cdd:cd17478 106 -ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
41-184 |
2.76e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.03 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 41 NLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTA 120
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1862189229 121 TSTIVAAIIPMSRRGEGINYYGLSTSlaaavgpfLGILMLHSLGYDFIIAFCVALIILCGIGSV 184
Cdd:cd17315 108 VPLYISEIAPAKIRGALGTLNQLMIT--------FGILLAYLLGLALSLSPPGWWRLMFALAAV 163
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
7-184 |
2.98e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 7 ALWTRSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLI 86
Cdd:cd17316 173 LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 87 YLISTAMYFY--TPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINY-YGLSTSLAAAVGPFLGILMLHSL 163
Cdd:cd17316 253 SGILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTG 332
|
170 180
....*....|....*....|.
gi 1862189229 164 GYDFIIAFCVALIILCGIGSV 184
Cdd:cd17316 333 GTGVPALILALLAIVALIVAL 353
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
41-384 |
3.22e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 45.64 E-value: 3.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 41 NLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTA 120
Cdd:cd17320 28 DLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 121 TSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIGSVImKFNEPKLDIDSEEH 200
Cdd:cd17320 108 ARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL-FLPETLPEEKRKPL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 201 KGIKISDYIEPRMNSISLVSILV-GFAYSGVIGFMAA----YTKDLNL-----ILAGTFFFVVYAVVITITRPLLGIVFD 270
Cdd:cd17320 187 LSSLLRAYKRVLKNRRFLGYALAlGLSFAGLFAYLAAapfiYIEQLGLspaqfGLLFALNAIALILGSLLNGRLVRRFGP 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 271 MKGENFVLYPCFIS-LALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPvHRIGVATSTYFIALDMGLGF 349
Cdd:cd17320 267 RRLLRLGLLLLLAAaLVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGAL 345
|
330 340 350
....*....|....*....|....*....|....*
gi 1862189229 350 GPYILGAIKEvVGYTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17320 346 AGALVGLLPN-GTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
47-384 |
4.74e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 45.25 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 47 SQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVA 126
Cdd:cd17502 30 SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 127 AIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIgsvimkfnepkldidseehkgikis 206
Cdd:cd17502 110 DLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALA------------------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 207 dyIEPRMNSISLVSILVGFAYSGVIGFMAAY---TKDLNLILAGtFFFVVYAVVITITRPLLGIVFDMKG-ENFVLYPCF 282
Cdd:cd17502 165 --LLRTILLSSIFGFLFGGALFGLIYYLPLYfqlVLGDSATKSG-VRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 283 ISLALGIFLLSIAHST---WLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGpyilGAIKE 359
Cdd:cd17502 242 ILMSVGAGLLTTLTLDtskWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG----VAITD 317
|
330 340
....*....|....*....|....*
gi 1862189229 360 VvgytsmFHVTVVVALLAFVAYYFL 384
Cdd:cd17502 318 V------FLVALALAALAFLLSLFL 336
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
222-384 |
7.14e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 7.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 222 LVGFAYSGVIGFMAAYTKDLNL-------ILAGtFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSI 294
Cdd:cd17391 7 FTGIGFSLIAPFLPLYIEQLGVtsgglveLWSG-LAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 295 AHSTWLILLSAVFVGLGYGtFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVA 374
Cdd:cd17391 86 VTNVWQLLILRLLQGVFSG-YVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLL 164
|
170
....*....|
gi 1862189229 375 LLAFVAYYFL 384
Cdd:cd17391 165 FLAFLLTLFF 174
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
13-380 |
7.65e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.55 E-value: 7.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 13 FVLDTLINFLVFLIYYLlIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTA 92
Cdd:cd17341 1 LHLSWLSFFLGFMVWFL-FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 93 MYF---YTPNLLMLdsVRFLNGFAyGITSTATSTIVAAIIPMSRRG--EGINYYG--LSTSLAAAVGPFL---GILMLHS 162
Cdd:cd17341 80 ALAlavSSYWGLLV--LGFLLGFA-GANFASGQPWASFWFPKEKIGgaAGGIAGAgnMGVAVSQLLAPLIagaIVFDGGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 163 LGYDFIIAFCVALIILCGIGSVIMKFNEPKLDIDSEEHKGIKISDYIEPRmnsISLVSILVGFAYSGVIGF---MAAYTK 239
Cdd:cd17341 157 VGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLKNYR---TWILSLLYGVTFGSFVGFsnvLPTYFK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 240 D---LNLILAGTFFFvVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSI-----AHSTWLILLSAVFVGLG 311
Cdd:cd17341 234 TrfgLPLVTAGILAA-LFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLslptsGTNLVLFLALFVALGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1862189229 312 YGTfmsnGQAVTVKIVP-VHRIGVATSTYFIALDMGLG--FGPYILGAIKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17341 313 AGA----GNGSVFRMVPfIFRRELGAVTGLVGAIGGLGgfFLPLLFGSSALMTGSGVGAFSLFGVLAVACTL 380
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
65-380 |
1.31e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 43.75 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 65 LLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVR----FLNGFaygitsTATSTIVAAIIPMSRRGEGINY 140
Cdd:cd17331 53 PLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRlpsvFMHAM------QAAQMVVTDLTDPGERAAALGR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 141 YGLSTSLAAAVGPFLGILMLHSLGyDFIIAFCVALIILCGIGSVIMKFNEPKLDIDSEEHKGIKISDY-----------I 209
Cdd:cd17331 127 LGLSYGIGMVVGSFLGGLLTKKFG-EQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSvfnlkeilrllR 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 210 EPRMNSISLVSILVGFAYSGVIGFMAAYTKD--------LNLILagTFFFVVYAVVITITRPLLGIVFdmkGENFVLYPC 281
Cdd:cd17331 206 LPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDffgltpeeNGYLM--SYAGVLGMVVQGLLVGPLTKRF---GERSLLKLS 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 282 FISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVAtstyfIALDMGL-----GFGPYILGA 356
Cdd:cd17331 281 VALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTA-----LGLSHALfslvrTVSPTIGGA 355
|
330 340
....*....|....*....|....
gi 1862189229 357 IKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17331 356 LLQAYGFPSFGLLGAAINGLLTVY 379
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
10-152 |
1.71e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 10 TRSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLI 89
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1862189229 90 STA-MYFYTPN--LLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVG 152
Cdd:cd17503 257 GTLlLAFLTPDtsLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIG 322
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
216-385 |
2.47e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 2.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 216 ISLVSILVGFAYSGVIGFMAAYTKDLNL-ILAGTFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSI 294
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLsASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 295 AHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKE--VVGYTSMFHVTVV 372
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170
....*....|...
gi 1862189229 373 VALLAFVAYYFLY 385
Cdd:cd06174 161 LALLAAILLLLVV 173
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
21-384 |
2.78e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 42.96 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 21 FLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRK--MLYLGLLIYLISTAMYFYTP 98
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKalLLLSLLAAVLFFLSLFFVAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 99 NLLMLDSVRFLngfaYGITSTATSTIVAAIIpMSRRGEGINYYGL-----STSLAAAVgPFLGILMLHSLGY-DFIIAFC 172
Cdd:cd17335 86 IFWLLLLLVIL----GAFFSAPVVPLVDSIT-LQYLGEERERYGKqrlwgSIGFGIAA-LLVGILIDRSSTYkNYTIAFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 173 VALIILCGIGSVIMKFNEPKLDIDSEEHKGIKISDYIEPRMNSISLVSILVGFAYSGVIGFMAAYTKDLNLI-------- 244
Cdd:cd17335 160 VFAVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSktligllw 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 245 ----LAGTFFFVVYAVVITitrpLLGIVFdmkgenfVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQ 320
Cdd:cd17335 240 tvgvVSEIPFFFFSSRLIQ----RFGHVG-------LLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAV 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1862189229 321 AVTVKIVPvHRIGVATSTYFIALDMGLG--FGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17335 309 SYASAAAP-PGLRATAQGLLQGLYFGLGggLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
21-258 |
5.22e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 41.98 E-value: 5.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 21 FLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNL 100
Cdd:TIGR00711 12 FMAVLDSTIVNVAIPTIAGD-LGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 101 LMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVAL-IILC 179
Cdd:TIGR00711 91 ELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIgIIVV 170
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1862189229 180 GIGSVIMKFNEPKLDIDseehkgikiSDYIEPRMNSISLVSILVGFAYSGVIGFMAAytkDLNLILAGTFFFVVYAVVI 258
Cdd:TIGR00711 171 VVAFFILPRDKPAASEN---------FDFLGLLLLSVGLGSLLYGLSEGPERGWFDS---NEILILSITGLVAIIAFVV 237
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
216-384 |
5.42e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.79 E-value: 5.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 216 ISLVSILVGFAYSGVIGFMAAYTKDLNL-----ILAGTFFFVVYAVVITITRPLLgivfDMKGENFVLYPCFISLALGIF 290
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQIAEDFHVseevaNLGVSLFVLGFGLGPLIWAPLS----ELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 291 LLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVT 370
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
|
170
....*....|....
gi 1862189229 371 VVVALLAFVAYYFL 384
Cdd:cd17323 160 AIISGFCLILIFLF 173
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-379 |
6.21e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 25 LIYYLLIVIIAVVAKdnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLD 104
Cdd:cd17355 18 IRYYFGVFIIPIIAE--FGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 105 SVRFLNGFA-YGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVALIILCGIGS 183
Cdd:cd17355 96 LLWGLLGGGgAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 184 VIMKFNEPKlDIDSEEHKGIKISDYIEPR---MNS-----ISLVSILVGFAYSGVIGFMAAYTKD--LNLILAGTFFFVV 253
Cdd:cd17355 176 LLLLRRRPA-DLALRAYDDASPASPGSTLkeaLRSasfwlLALAFFLCGFAVVGLIVHLVPYLADrgISPAAAAVALALI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 254 yAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILL-SAVFVGLGYGTFMSNGQAVTVKIVPVHRI 332
Cdd:cd17355 255 -GLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLlFAALFGLGWGATVPLTAALAARYFGARSY 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1862189229 333 GVATSTYFIALDMGLGFGPYILGAIKEVVG-YTSMFHVTVVVALLAFV 379
Cdd:cd17355 334 GTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAAL 381
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
11-181 |
6.58e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.40 E-value: 6.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 11 RSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRK--MLYLGLLIYL 88
Cdd:cd17502 167 RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKplIVIGTILMSV 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 89 ISTAMYFYTPN--LLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGpflgiLMLHSLGYD 166
Cdd:cd17502 247 GAGLLTTLTLDtsKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG-----VAITDVFLV 321
|
170
....*....|....*
gi 1862189229 167 FIIAFCVALIILCGI 181
Cdd:cd17502 322 ALALAALAFLLSLFL 336
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-181 |
8.03e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 8.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 11 RSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFIS-ILGCRKMLYLGLLIYLI 89
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 90 STAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFL-GILMLHSLGYDFI 168
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLaGFLLAATFGLTGA 362
|
170
....*....|...
gi 1862189229 169 IAFCVALIILCGI 181
Cdd:cd06174 363 FLVLAVLLLLAAI 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
4-181 |
9.72e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 9.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 4 AKEALWTRSFVLDTLINFLVFLIYYLLIVIIAVVAKDnLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLG 83
Cdd:cd17355 203 LKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAAS 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 84 LLIYLISTAMYFYTPNL-LMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHS 162
Cdd:cd17355 282 YALRALGLALLLLLPFPpLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR 361
|
170 180
....*....|....*....|
gi 1862189229 163 LG-YDFIIAFCVALIILCGI 181
Cdd:cd17355 362 TGsYTAAWALAVALGLIAAL 381
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
216-384 |
1.32e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 216 ISLVSILVGFAYSGVIGFMAAYTKDLNLI----LAGTFFFVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFL 291
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLgasgYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 292 LSIAHSTWLILLSAVFVGLGYGTFmSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTV 371
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170
....*....|...
gi 1862189229 372 VVALLAFVAYYFL 384
Cdd:cd17330 160 ALALLNLVLVLFF 172
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
245-390 |
1.36e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.63 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 245 LAGTFFFVVYAvvitITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTV 324
Cdd:cd17319 42 LIASAFFLGYA----LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALA 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1862189229 325 KIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYFLYGRYVG 390
Cdd:cd17319 118 EWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVWG 183
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
96-383 |
1.46e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.71 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 96 YTPNLLMLDSVRFLNGFAYGITSTATsTIVAAIIPMSRRGeginyYGLSTSLAAAV-----GPFLGILMLHSLGYDF--- 167
Cdd:cd17391 85 FVTNVWQLLILRLLQGVFSGYVPNAT-ALIASQTPKEKSG-----WALGTLSTGVVagtliGPLLGGFLADLFGIRNvff 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 168 ---IIAFCVALIILCGI---GSVIMKFNE--PKLDIDSEEHKGIKISDYIEPRMNSISLVSILvgfaysgviGFMAAYTK 239
Cdd:cd17391 159 itgGLLFLAFLLTLFFVkedFKPVEKKKMvsTKEVWNSVPNPSLLISLFVTTFIIQLANQSIE---------PILTLYIR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 240 DLNLILAGTFF-----FVVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGT 314
Cdd:cd17391 230 QLMGDASNLAFisglvFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGG 309
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1862189229 315 FMSNGQAVTVKIVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVAYYF 383
Cdd:cd17391 310 LLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
167-384 |
2.70e-03 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 39.56 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 167 FIIAFCVALIILCGIGSVIMKFNEPKLDIDSEEHKG-IKISDYIEPRMnSISLVSILVGFAYSGVIGFMAAYTK------ 239
Cdd:cd17340 170 IGAITCLFSLICAIILGLLDKRAERILKKESNKTGEvIKLSDVKDFPL-SFWLICIICVFYYVAVFPFIGLGTVffeeky 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 240 DLNLILAGTFFFVVYaVVITITRPLLGIVFDMKGENFVlypcFISLALGIFLLS---IAHSTWLILLSAVFVGLGYgTFM 316
Cdd:cd17340 249 GFSPSEAAAVNSIVY-IISAAASPVFGFLVDKVGRNIL----WVLIALVITLLGhllLAFTFVNPLIAMVIMGIGY-SML 322
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1862189229 317 SNGQAVTVK-IVPVHRIGVATSTYFIALDMGLGFGPYILGAIKEVVGY---TSMFHVTVVVALLAFVAYYFL 384
Cdd:cd17340 323 ACALWPMVPlVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYlllEVFFIACLCVSLIALIILYLV 394
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
18-178 |
2.85e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.51 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 18 LINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVG-IYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLIS-TAMYF 95
Cdd:cd17331 214 LVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSyAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGyLLLAF 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 96 YTPNLLMLDSVRFLnGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFLGILMLHSLGYDFIIAFCVAL 175
Cdd:cd17331 294 VTTVWQLLVLLLPL-VIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAI 372
|
...
gi 1862189229 176 IIL 178
Cdd:cd17331 373 NGL 375
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
11-336 |
3.26e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 39.21 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 11 RSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLIS 90
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 91 TA-MYFYTPNLLMLDSVRFLNGFAyGITSTATSTIVAAIIPMSRRG--EGINYYG--LSTSLAAAVGPFLGILMLHSLGY 165
Cdd:TIGR00886 81 CLwAGLAVQSYSVLLLIRLFIGIA-GGSFASCMPWISFFFPKKIQGtaLGLAAGWgnMGGGVAQFVMPPIIGSLIFGGGQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 166 DFIIAFCVA-------LIILCGIGSVIMKFNEPKLDIDSEEHKGIKISDYIEPRMNSISLVSILVGF-AYSGVIGFMAAY 237
Cdd:TIGR00886 160 PAHLAWGWAfvivpagILLLPALLIFFVGADTPPGKPATGKLSFKEALKVFGNRHTWILALLYSVTFgSFLGVSSIFAML 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 238 TKD---LNLILAGTFFFvVYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGT 314
Cdd:TIGR00886 240 FKDqfgLSKVQAGAYAS-LGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFF 318
|
330 340
....*....|....*....|....*
gi 1862189229 315 FMSNGQAVTVKIVPV---HRIGVAT 336
Cdd:TIGR00886 319 FAGAGNGSTFALVPHifrRATGAVS 343
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
285-388 |
4.91e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 38.71 E-value: 4.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 285 LALGIFLLSIA-HSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPV--HRIGVATSTYFIALDMGLGFGPYILGAIKEVV 361
Cdd:cd17346 81 MALGYLLLALSpFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDEndPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNY 160
|
90 100
....*....|....*....|....*..
gi 1862189229 362 GYTSMFHVTVVVALLAFVAYYFLYGRY 388
Cdd:cd17346 161 GYHYGFGLAAVGMLLGLLIFLLGRKKL 187
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
253-380 |
5.69e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 5.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 253 VYAVVITITRPLLGIVFDMKGENFVLYPCFISLALGIFLLSIAHSTWLILLSAVFVGLGYGTFMSNGQAVTVKIVPVHRI 332
Cdd:cd17503 39 SYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1862189229 333 GVATSTYFIALDMGLGFGPYILGAIKEVVGYTSMFHVTVVVALLAFVA 380
Cdd:cd17503 119 GAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
39-135 |
9.65e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 37.93 E-value: 9.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 39 KDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGCRKMLYLGLLIYLISTAMYFYTPNLLMLDSVRFLNGFAYGITS 118
Cdd:cd17359 28 QTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGAS 107
|
90
....*....|....*..
gi 1862189229 119 TATSTIVAAIIPMSRRG 135
Cdd:cd17359 108 ALVPMYIAEVAPAEIRG 124
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-186 |
9.95e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 37.94 E-value: 9.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 11 RSFVLDTLINFLVFLIYYLLIVIIAVVAKDNLHATASQAGLAVGIYIIGTVVARLLAGRFISILGC---RKMLYLGLLIY 87
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862189229 88 LISTAMYFYTPNLLMLDSVRFLNGFAYGITSTATSTIVAAIIPMSRRGEGINYYGLSTSLAAAVGPFL-GILMLHSLGYD 166
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDATGSYT 338
|
170 180
....*....|....*....|
gi 1862189229 167 FIIAFCVALIILCGIGSVIM 186
Cdd:cd17319 339 AAFLFLAAVALLAALLVLLL 358
|
|
| |
