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Conserved domains on  [gi|1681981610|dbj|BBL08031|]
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Holliday junction ATP-dependent DNA helicase RuvB [Alistipes onderdonkii subsp. vulgaris]

Protein Classification

Holliday junction branch migration DNA helicase RuvB( domain architecture ID 11455025)

Holliday junction branch migration DNA helicase RuvB is an ATPase that forms a complex with RuvA; the helicase RuvAB mediates the Holliday junction migration by localized denaturation and reannealing

CATH:  1.10.10.10|1.10.8.60
EC:  3.6.4.12
Gene Symbol:  ruvB
Gene Ontology:  GO:0003677|GO:0005524|GO:0009378
PubMed:  11478862|7625278

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 3-332 0e+00

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


:

Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 628.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   3 IVRNTESDLEFENKIRPQELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSG 82
Cdd:COG2255     8 SSSASEEEDALERSLRPKRLDEYIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLAHIIANEMGVNIRITSG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  83 PVLDKPGDLAGLLTNLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGLLT 162
Cdd:COG2255    88 PAIEKPGDLAAILTNLEEGDVLFIDEIHRLSRVVEEILYPAMEDFRLDIVIGKGPAARSIRLDLPPFTLVGATTRAGLLT 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 163 SPLRARFGIQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEGHIDLGITR 242
Cdd:COG2255   168 SPLRDRFGIVLRLEFYTVEELAEIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKGDGVITLEIAD 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 243 IGLSALNIDSRGLDQMDNKILGTIIEKFGGGPVGLNTIATAVGEDAGTIEEVYEPFLIKEGFLKRTPRGREATELAYRHL 322
Cdd:COG2255   248 AALELLEVDELGLDEMDRRILETIIEKFGGGPVGLETLAAALGEERDTIEDVYEPYLIQQGFLQRTPRGRVATPKAYEHL 327

                         330
                  ....*....|
gi 1681981610 323 GVTPPGKPET 332
Cdd:COG2255   328 GLKPPEDAGT 337
 
Name Accession Description Interval E-value
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 3-332 0e+00

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 628.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   3 IVRNTESDLEFENKIRPQELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSG 82
Cdd:COG2255     8 SSSASEEEDALERSLRPKRLDEYIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLAHIIANEMGVNIRITSG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  83 PVLDKPGDLAGLLTNLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGLLT 162
Cdd:COG2255    88 PAIEKPGDLAAILTNLEEGDVLFIDEIHRLSRVVEEILYPAMEDFRLDIVIGKGPAARSIRLDLPPFTLVGATTRAGLLT 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 163 SPLRARFGIQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEGHIDLGITR 242
Cdd:COG2255   168 SPLRDRFGIVLRLEFYTVEELAEIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKGDGVITLEIAD 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 243 IGLSALNIDSRGLDQMDNKILGTIIEKFGGGPVGLNTIATAVGEDAGTIEEVYEPFLIKEGFLKRTPRGREATELAYRHL 322
Cdd:COG2255   248 AALELLEVDELGLDEMDRRILETIIEKFGGGPVGLETLAAALGEERDTIEDVYEPYLIQQGFLQRTPRGRVATPKAYEHL 327

                         330
                  ....*....|
gi 1681981610 323 GVTPPGKPET 332
Cdd:COG2255   328 GLKPPEDAGT 337
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
1-326 0e+00

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 594.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   1 MSIVRNTESDLEFENKIRPQELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVT 80
Cdd:PRK00080    3 VSPETLEEEEDEIERSLRPKSLDEFIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIRIT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  81 SGPVLDKPGDLAGLLTNLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGL 160
Cdd:PRK00080   83 SGPALEKPGDLAAILTNLEEGDVLFIDEIHRLSPVVEEILYPAMEDFRLDIMIGKGPAARSIRLDLPPFTLIGATTRAGL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 161 LTSPLRARFGIQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEGHIDLGI 240
Cdd:PRK00080  163 LTSPLRDRFGIVQRLEFYTVEELEKIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKGDGVITKEI 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 241 TRIGLSALNIDSRGLDQMDNKILGTIIEKFGGGPVGLNTIATAVGEDAGTIEEVYEPFLIKEGFLKRTPRGREATELAYR 320
Cdd:PRK00080  243 ADKALDMLGVDELGLDEMDRKYLRTIIEKFGGGPVGLDTLAAALGEERDTIEDVYEPYLIQQGFIQRTPRGRVATPKAYE 322


                  ....*.
gi 1681981610 321 HLGVTP 326
Cdd:PRK00080  323 HLGLNP 328
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 20-323 4.83e-169

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 472.17  E-value: 4.83e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  20 QELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVLDKPGDLAGLLTNLN 99
Cdd:TIGR00635   1 KLLAEFIGQEKVKEQLQLFIEAAKMRQEALDHLLLYGPPGLGKTTLAHIIANEMGVNLKITSGPALEKPGDLAAILTNLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 100 PGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGLLTSPLRARFGIQCHLEYYD 179
Cdd:TIGR00635  81 EGDVLFIDEIHRLSPAVEELLYPAMEDFRLDIVIGKGPSARSVRLDLPPFTLVGATTRAGMLTSPLRDRFGIILRLEFYT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 180 APVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEGHIDLGITRIGLSALNIDSRGLDQMD 259
Cdd:TIGR00635 161 VEELAEIVSRSAGLLNVEIEPEAALEIARRSRGTPRIANRLLRRVRDFAQVRGQKIINRDIALKALEMLMIDELGLDEID 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1681981610 260 NKILGTIIEKFGGGPVGLNTIATAVGEDAGTIEEVYEPFLIKEGFLKRTPRGREATELAYRHLG 323
Cdd:TIGR00635 241 RKLLSVLIEQFQGGPVGLKTLAAALGEDADTIEDVYEPYLLQIGFLQRTPRGRIATELAYEHLG 304
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 17-175 4.10e-109

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 314.44  E-value: 4.10e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  17 IRPQELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVLDKPGDLAGLLT 96
Cdd:pfam05496   1 LRPRTLDEYIGQEKVKENLKIFIEAAKQRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAIERPGDLAAILT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1681981610  97 NLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGLLTSPLRARFGIQCHL 175
Cdd:pfam05496  81 NLEPGDVLFIDEIHRLNRAVEEILYPAMEDFRLDIVIGKGPSARSIRLDLPPFTLVGATTRAGLLTSPLRDRFGIVLRL 159
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 41-177 8.71e-12

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 62.16  E-value: 8.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  41 AALMRGDSLDHVLLHGPPGLGKTTLANIIANEMH-AQLRV--TSGPVLDKPGDLAGL-----------LTNLNPGDVLFI 106
Cdd:cd00009    11 REALELPPPKNLLLYGPPGTGKTTLARAIANELFrPGAPFlyLNASDLLEGLVVAELfghflvrllfeLAEKAKPGVLFI 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1681981610 107 DEIHRLSPIVEEYLYSAMEDYKIDIvldkgpsarsiqIELAPFTLIGATTR--SGLLTSPLRARFGIQCHLEY 177
Cdd:cd00009    91 DEIDSLSRGAQNALLRVLETLNDLR------------IDRENVRVIGATNRplLGDLDRALYDRLDIRIVIPL 151
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 51-179 1.74e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.06  E-value: 1.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   51 HVLLHGPPGLGKTTLANIIANEM-------------------HAQLRVTSGPVLDKPGDLAGLLTNL------NPGDVLF 105
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELgppgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLAlalarkLKPDVLI 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1681981610  106 IDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGpsarsiqielAPFTLIGATTRSG-LLTSPLRARFGIQCHLEYYD 179
Cdd:smart00382  84 LDEITSLLDAEQEALLLLLEELRLLLLLKSE----------KNLTVILTTNDEKdLGPALLRRRFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 3-332 0e+00

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 628.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   3 IVRNTESDLEFENKIRPQELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSG 82
Cdd:COG2255     8 SSSASEEEDALERSLRPKRLDEYIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLAHIIANEMGVNIRITSG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  83 PVLDKPGDLAGLLTNLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGLLT 162
Cdd:COG2255    88 PAIEKPGDLAAILTNLEEGDVLFIDEIHRLSRVVEEILYPAMEDFRLDIVIGKGPAARSIRLDLPPFTLVGATTRAGLLT 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 163 SPLRARFGIQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEGHIDLGITR 242
Cdd:COG2255   168 SPLRDRFGIVLRLEFYTVEELAEIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKGDGVITLEIAD 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 243 IGLSALNIDSRGLDQMDNKILGTIIEKFGGGPVGLNTIATAVGEDAGTIEEVYEPFLIKEGFLKRTPRGREATELAYRHL 322
Cdd:COG2255   248 AALELLEVDELGLDEMDRRILETIIEKFGGGPVGLETLAAALGEERDTIEDVYEPYLIQQGFLQRTPRGRVATPKAYEHL 327

                         330
                  ....*....|
gi 1681981610 323 GVTPPGKPET 332
Cdd:COG2255   328 GLKPPEDAGT 337
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
1-326 0e+00

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 594.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   1 MSIVRNTESDLEFENKIRPQELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVT 80
Cdd:PRK00080    3 VSPETLEEEEDEIERSLRPKSLDEFIGQEKVKENLKIFIEAAKKRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIRIT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  81 SGPVLDKPGDLAGLLTNLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGL 160
Cdd:PRK00080   83 SGPALEKPGDLAAILTNLEEGDVLFIDEIHRLSPVVEEILYPAMEDFRLDIMIGKGPAARSIRLDLPPFTLIGATTRAGL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 161 LTSPLRARFGIQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEGHIDLGI 240
Cdd:PRK00080  163 LTSPLRDRFGIVQRLEFYTVEELEKIVKRSARILGVEIDEEGALEIARRSRGTPRIANRLLRRVRDFAQVKGDGVITKEI 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 241 TRIGLSALNIDSRGLDQMDNKILGTIIEKFGGGPVGLNTIATAVGEDAGTIEEVYEPFLIKEGFLKRTPRGREATELAYR 320
Cdd:PRK00080  243 ADKALDMLGVDELGLDEMDRKYLRTIIEKFGGGPVGLDTLAAALGEERDTIEDVYEPYLIQQGFIQRTPRGRVATPKAYE 322


                  ....*.
gi 1681981610 321 HLGVTP 326
Cdd:PRK00080  323 HLGLNP 328
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 20-323 4.83e-169

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 472.17  E-value: 4.83e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  20 QELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVLDKPGDLAGLLTNLN 99
Cdd:TIGR00635   1 KLLAEFIGQEKVKEQLQLFIEAAKMRQEALDHLLLYGPPGLGKTTLAHIIANEMGVNLKITSGPALEKPGDLAAILTNLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 100 PGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGLLTSPLRARFGIQCHLEYYD 179
Cdd:TIGR00635  81 EGDVLFIDEIHRLSPAVEELLYPAMEDFRLDIVIGKGPSARSVRLDLPPFTLVGATTRAGMLTSPLRDRFGIILRLEFYT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 180 APVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEGHIDLGITRIGLSALNIDSRGLDQMD 259
Cdd:TIGR00635 161 VEELAEIVSRSAGLLNVEIEPEAALEIARRSRGTPRIANRLLRRVRDFAQVRGQKIINRDIALKALEMLMIDELGLDEID 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1681981610 260 NKILGTIIEKFGGGPVGLNTIATAVGEDAGTIEEVYEPFLIKEGFLKRTPRGREATELAYRHLG 323
Cdd:TIGR00635 241 RKLLSVLIEQFQGGPVGLKTLAAALGEDADTIEDVYEPYLLQIGFLQRTPRGRIATELAYEHLG 304
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 17-175 4.10e-109

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 314.44  E-value: 4.10e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  17 IRPQELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVLDKPGDLAGLLT 96
Cdd:pfam05496   1 LRPRTLDEYIGQEKVKENLKIFIEAAKQRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAIERPGDLAAILT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1681981610  97 NLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGPSARSIQIELAPFTLIGATTRSGLLTSPLRARFGIQCHL 175
Cdd:pfam05496  81 NLEPGDVLFIDEIHRLNRAVEEILYPAMEDFRLDIVIGKGPSARSIRLDLPPFTLVGATTRAGLLTSPLRDRFGIVLRL 159
AAA_lid_4 pfam17864
RuvB AAA lid domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes ...
 178-251 1.52e-33

RuvB AAA lid domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This entry contains the AAA lid domain that is found to the C-terminus of the AAA domain.


Pssm-ID: 380039 [Multi-domain]  Cd Length: 74  Bit Score: 118.31  E-value: 1.52e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1681981610 178 YDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEGHIDLGITRIGLSALNID 251
Cdd:pfam17864   1 YSVEELELIVKRSARILGVEIDEEGAAEIARRSRGTPRIANRLLRRVRDFAQVKGDGRITLEIADAALDLLEVD 74
RuvB_C pfam05491
RuvB C-terminal winged helix domain; The RuvB protein makes up part of the RuvABC revolvasome ...
 254-323 1.88e-27

RuvB C-terminal winged helix domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family consists of the C-terminal region of the RuvB protein which is thought to be helicase DNA-binding domain.


Pssm-ID: 398896 [Multi-domain]  Cd Length: 72  Bit Score: 102.25  E-value: 1.88e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 254 GLDQMDNKILGTIIEKFGGGPVGLNTIATAVGEDAGTIEEVYEPFLIKEGFLKRTPRGREATELAYRHLG 323
Cdd:pfam05491   3 GLDELDINYLKTLYENFKGGPVGLDTLAAILGEDKDTIEDVIEPYLLRLGLIERTSRGRIITPKGYKYLK 72
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 16-256 3.65e-21

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 93.23  E-value: 3.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  16 KIRPQELETFSGQDKIVDNLHIFIKAalMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLR----VTSG-----PVLD 86
Cdd:PRK13342    5 RMRPKTLDEVVGQEHLLGPGKPLRRM--IEAGRLSSMILWGPPGTGKTTLARIIAGATDAPFEalsaVTSGvkdlrEVIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  87 KpgdlAGLLTNLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIdivldkgpsarsiqielapfTLIGATTR--SGLLTSP 164
Cdd:PRK13342   83 E----ARQRRSAGRRTILFIDEIHRFNKAQQDALLPHVEDGTI--------------------TLIGATTEnpSFEVNPA 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 165 LRARfgiqCH---LEYYDAPVLAGIVRR----SARILdVSIDDDAAHEVALRSRGTPRIA-NAL-----LRRVRDFAMVK 231
Cdd:PRK13342  139 LLSR----AQvfeLKPLSEEDIEQLLKRaledKERGL-VELDDEALDALARLANGDARRAlNLLelaalGVDSITLELLE 213

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1681981610 232 -------------GEGHIDLgitrigLSALnIDS-RGLD 256
Cdd:PRK13342  214 ealqkraarydkdGDEHYDL------ISAL-HKSiRGSD 245
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 52-177 4.94e-21

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 87.26  E-value: 4.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGP------VLDKPGDLAGLLTNL--NPGDVLFIDEIHRLSPI-------- 115
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSelvskyVGESEKRLRELFEAAkkLAPCVIFIDEIDALAGSrgsggdse 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1681981610 116 ---VEEYLYSAMEDYKIDIvldkgpsarsiqielAPFTLIGATTRSGLLTSPLRARFGIQCHLEY 177
Cdd:pfam00004  81 srrVVNQLLTELDGFTSSN---------------SKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 16-238 3.45e-15

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 75.86  E-value: 3.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  16 KIRPQELETFSGQDKIVDN---LHIFIKAalmrgDSLDHVLLHGPPGLGKTTLANIIANEMHAQLR----VTSG-----P 83
Cdd:COG2256    18 RMRPRTLDEVVGQEHLLGPgkpLRRAIEA-----GRLSSMILWGPPGTGKTTLARLIANATDAEFValsaVTSGvkdirE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  84 VLDKpgdlAGLLTNLNPGDVLFIDEIHRLS--------PIVEEylysamedykidivldkgpsaRSIqielapfTLIGAT 155
Cdd:COG2256    93 VIEE----ARERRAYGRRTILFVDEIHRFNkaqqdallPHVED---------------------GTI-------TLIGAT 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 156 TR--SGLLTSPLRARfgiqCH---LEYYDAPVLAGIVRR----SARIL---DVSIDDDAAHEVALRSRGTPRIANALLRR 223
Cdd:COG2256   141 TEnpSFEVNSALLSR----CRvfvLKPLSEEDLEQLLERaladDERGLggyKLELDDEALEALARLADGDARRALNALEL 216

                         250
                  ....*....|....*
gi 1681981610 224 VRDFAMVKGEGHIDL 238
Cdd:COG2256   217 AVLSAPPDGVIEITL 231
PRK13341 PRK13341
AAA family ATPase;
16-156 1.97e-12

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 68.16  E-value: 1.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  16 KIRPQELETFSGQDkivdnlHIFIKAALMR----GDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSGpVLDKPGDL 91
Cdd:PRK13341   21 RLRPRTLEEFVGQD------HILGEGRLLRraikADRVGSLILYGPPGVGKTTLARIIANHTRAHFSSLNA-VLAGVKDL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1681981610  92 A-------------GLLTnlnpgdVLFIDEIHRLSpiveeylySAMEDykidivldkgpsARSIQIELAPFTLIGATT 156
Cdd:PRK13341   94 RaevdrakerlerhGKRT------ILFIDEVHRFN--------KAQQD------------ALLPWVENGTITLIGATT 145
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 41-177 8.71e-12

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 62.16  E-value: 8.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  41 AALMRGDSLDHVLLHGPPGLGKTTLANIIANEMH-AQLRV--TSGPVLDKPGDLAGL-----------LTNLNPGDVLFI 106
Cdd:cd00009    11 REALELPPPKNLLLYGPPGTGKTTLARAIANELFrPGAPFlyLNASDLLEGLVVAELfghflvrllfeLAEKAKPGVLFI 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1681981610 107 DEIHRLSPIVEEYLYSAMEDYKIDIvldkgpsarsiqIELAPFTLIGATTR--SGLLTSPLRARFGIQCHLEY 177
Cdd:cd00009    91 DEIDSLSRGAQNALLRVLETLNDLR------------IDRENVRVIGATNRplLGDLDRALYDRLDIRIVIPL 151
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 27-225 5.43e-11

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 62.49  E-value: 5.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  27 GQDKIVDNLHIfikAALMRGdsldHVLLHGPPGLGKTTLANIIANEMHAQL-RV--TSGpvLDkPGDLAGlLTNLNPGD- 102
Cdd:COG0714    16 GQEELIELVLI---ALLAGG----HLLLEGVPGVGKTTLAKALARALGLPFiRIqfTPD--LL-PSDILG-TYIYDQQTg 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 103 ------------VLFIDEIHRLSPIVEEYLYSAMEDYKIDIvldkgpSARSIQIElAPFTLIgAT--------TRSglLT 162
Cdd:COG0714    85 efefrpgplfanVLLADEINRAPPKTQSALLEAMEERQVTI------PGGTYKLP-EPFLVI-ATqnpieqegTYP--LP 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 163 SPLRARFGIQCHLEYYDAPVLAGIVRRSARILDVSI-------DDDAAHEVALRSRGTPRIANALLRRVR 225
Cdd:COG0714   155 EAQLDRFLLKLYIGYPDAEEEREILRRHTGRHLAEVepvlspeELLALQELVRQVHVSEAVLDYIVDLVR 224
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 16-237 4.39e-10

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 60.31  E-value: 4.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  16 KIRPQELETFSGQDKIVDNLHIFIKAALMRGDSLD--------HVLLHGPPGLGKTTLANIIANEMHAQL-RVTSGPVLD 86
Cdd:COG0464   150 ELREAILDDLGGLEEVKEELRELVALPLKRPELREeyglppprGLLLYGPPGTGKTLLARALAGELGLPLiEVDLSDLVS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  87 KP-GD----LAGLLT---NLNPGdVLFIDEIHRLSPIVEE-----------YLYSAMEDYKIDIVldkgpsarsiqiela 147
Cdd:COG0464   230 KYvGEteknLREVFDkarGLAPC-VLFIDEADALAGKRGEvgdgvgrrvvnTLLTEMEELRSDVV--------------- 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 148 pftLIGATTRSGLLTSPLRARFGIQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDF 227
Cdd:COG0464   294 ---VIAATNRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEELAEATEGLSGADIRNVVRRAALQ 370

                         250
                  ....*....|
gi 1681981610 228 AMVKGEGHID 237
Cdd:COG0464   371 ALRLGREPVT 380
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 52-114 2.88e-08

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 52.68  E-value: 2.88e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGP-VLDK-PGDLAGLL-------TNLNPGdVLFIDEIHRLSP 114
Cdd:cd19503    37 VLLHGPPGTGKTLLARAVANEAGANFLSISGPsIVSKyLGESEKNLreifeeaRSHAPS-IIFIDEIDALAP 107
PRK04195 PRK04195
replication factor C large subunit; Provisional
 16-73 5.70e-08

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 54.16  E-value: 5.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1681981610  16 KIRPQELETFSGQDKIVDNLHIFIKAALmRGDSLDHVLLHGPPGLGKTTLANIIANEM 73
Cdd:PRK04195    7 KYRPKTLSDVVGNEKAKEQLREWIESWL-KGKPKKALLLYGPPGVGKTSLAHALANDY 63
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 52-114 8.56e-08

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 51.13  E-value: 8.56e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTS---------GPVLDKPGDLAGLLTNLNPGdVLFIDEIHRLSP 114
Cdd:cd19481    29 ILLYGPPGTGKTLLAKALAGELGLPLIVVKlssllskyvGESEKNLRKIFERARRLAPC-ILFIDEIDAIGR 99
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 51-179 1.74e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.06  E-value: 1.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   51 HVLLHGPPGLGKTTLANIIANEM-------------------HAQLRVTSGPVLDKPGDLAGLLTNL------NPGDVLF 105
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELgppgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLAlalarkLKPDVLI 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1681981610  106 IDEIHRLSPIVEEYLYSAMEDYKIDIVLDKGpsarsiqielAPFTLIGATTRSG-LLTSPLRARFGIQCHLEYYD 179
Cdd:smart00382  84 LDEITSLLDAEQEALLLLLEELRLLLLLKSE----------KNLTVILTTNDEKdLGPALLRRRFDRRIVLLLIL 148
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 51-131 2.74e-07

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 49.09  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  51 HVLLHGPPGLGKTTLANIIANEMHAQL-RVTSGPVLdKPGDLAGllTN----------LNPG----DVLFIDEIHRLSPI 115
Cdd:pfam07726   1 HVLLEGVPGLAKTLLVRTLARSLGLDFrRIQFTPDL-LPSDITG--TEvfdqktrefeFRPGpvfaNVLLADEINRAPPK 77

                          90
                  ....*....|....*.
gi 1681981610 116 VEEYLYSAMEDYKIDI 131
Cdd:pfam07726  78 TQSALLEAMQERQVTI 93
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 52-109 1.34e-06

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 49.23  E-value: 1.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGP-VLDK-PGDLAGLLTNL------NPGDVLFIDEI 109
Cdd:COG1222   115 VLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSeLVSKyIGEGARNVREVfelareKAPSIIFIDEI 180
rfc PRK00440
replication factor C small subunit; Reviewed
 16-73 1.58e-06

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 49.10  E-value: 1.58e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1681981610  16 KIRPQELETFSGQDKIVDNLHIFIKAalmrgDSLDHVLLHGPPGLGKTTLANIIANEM 73
Cdd:PRK00440   10 KYRPRTLDEIVGQEEIVERLKSYVKE-----KNMPHLLFAGPPGTGKTTAALALAREL 62
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 52-114 1.81e-06

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 47.28  E-value: 1.81e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGP-VLDK-PGDLAGLLTNL------NPGDVLFIDEIHRLSP 114
Cdd:cd19511    30 VLLYGPPGCGKTLLAKALASEAGLNFISVKGPeLFSKyVGESERAVREIfqkarqAAPCIIFFDEIDSLAP 100
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 52-169 2.14e-06

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 47.01  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVL---------DKPGDLAGLLTNLNPGdVLFIDEIHRLSPIVEeylyS 122
Cdd:cd19518    37 VLLHGPPGCGKTMLANAIAGELKVPFLKISATEIvsgvsgeseEKIRELFDQAISNAPC-IVFIDEIDAITPKRE----S 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1681981610 123 AMEDYKIDIVLDKGPSARSIQIEL---APFTLIGATTRSGLLTSPLR--ARF 169
Cdd:cd19518   112 AQREMERRIVSQLLTCMDELNNEKtagGPVLVIGATNRPDSLDPALRraGRF 163
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 51-169 2.51e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 46.13  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  51 HVLLHGPPGLGKTTLANIIAN----------EMHAQL-------RVTSGPVLDKPGDLAgLLTNLNPGDVLFIDEIHRLS 113
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAalsnrpvfyvQLTRDTteedlfgRRNIDPGGASWVDGP-LVRAAREGEIAVLDEINRAN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 114 PIVEEYLYSAMEDYKIDIVldkgPSARSIQIELAPFTLIGATTRSGL----LTSPLRARF 169
Cdd:pfam07728  80 PDVLNSLLSLLDERRLLLP----DGGELVKAAPDGFRLIATMNPLDRglneLSPALRSRF 135
PRK04132 PRK04132
replication factor C small subunit; Provisional
 16-131 2.61e-06

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 49.07  E-value: 2.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  16 KIRPQELETFSGQDKIVDNLHIFIKAAlmrgdSLDHVLLHGPPGLGK--TTLANIIANemhAQLRvTSGPVLDKPGDLAG 93
Cdd:PRK04132   12 KYRPQRLDDIVGQEHIVKRLKHYVKTG-----SMPHLLFAGPPGVGKclTGDTKVIAN---GELF-EIGELVEKISNGKF 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1681981610  94 LLTNLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDI 131
Cdd:PRK04132   83 GPTPVNGLKVLGIDEDGKLREFEVQYVYKDKTNRLIKI 120
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
41-271 9.18e-06

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 46.72  E-value: 9.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  41 AALMR-----GDSLDHVLLHGPPGLGKTTLANIIANEMHAQ------LRVTSG-PVLD-----KPGDLAGLLTNLNPGDV 103
Cdd:COG0593    21 AAALAvaewpGKAYNPLFLYGGVGLGKTHLLHAIGNEALENnpgarvVYLTAEeFTNDfinaiRNNTIEEFKEKYRSVDV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 104 LFIDEIHRLSpiveeylysamedykidivldkgpSARSIQIELapFTLIGATTRSG---LLTS---P---------LRAR 168
Cdd:COG0593   101 LLIDDIQFLA------------------------GKEATQEEF--FHTFNALREAGkqiVLTSdrpPkelpgleerLRSR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610 169 F--GIQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAMVKGEgHIDLGITRIGLS 246
Cdd:COG0593   155 LewGLVVDIQPPDLETRIAILRKKAADRGLELPDEVLEYLARRIERNVRELEGALNRLDAYALLTGR-PITLELAREVLK 233

                         250       260
                  ....*....|....*....|....*
gi 1681981610 247 ALNIDSRGLDQMDNkILGTIIEKFG 271
Cdd:COG0593   234 DLLRAQKKEITIED-IQKAVAEYFG 257
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 16-217 1.73e-05

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 45.75  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  16 KIRPQELETFSGQDKIVDNLHIFIKAAlmrgdSLDHVLLHGPPGLGKTTLANIIANEMHAqlrvtsgpvldKPGDlaGLL 95
Cdd:PRK12402    8 KYRPALLEDILGQDEVVERLSRAVDSP-----NLPHLLVQGPPGSGKTAAVRALARELYG-----------DPWE--NNF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  96 TNLNPGDVL---------------FIDEIHR--------LSPIVEEYL-YSAME-DYKIdIVLDKGPSARS-IQIEL--- 146
Cdd:PRK12402   70 TEFNVADFFdqgkkylvedprfahFLGTDKRirsskidnFKHVLKEYAsYRPLSaDYKT-ILLDNAEALREdAQQALrri 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1681981610 147 -----APFTLIGATTRSGLLTSPLRARfGIQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIA 217
Cdd:PRK12402  149 meqysRTCRFIIATRQPSKLIPPIRSR-CLPLFFRAPTDDELVDVLESIAEAEGVDYDDDGLELIAYYAGGDLRKA 223
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 52-118 1.78e-05

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 44.35  E-value: 1.78e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGP-VLDK-PGDLAGLLTNL------NPGDVLFIDEIHRLSPIVEE 118
Cdd:cd19519    37 ILLYGPPGTGKTLIARAVANETGAFFFLINGPeIMSKlAGESESNLRKAfeeaekNAPAIIFIDEIDAIAPKREK 111
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 52-118 2.01e-05

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 46.44  E-value: 2.01e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGP-VLDK-PGDLAGLLTNL------NPGDVLFIDEIHRLSPIVEE 118
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAYFISINGPeIMSKyYGESEERLREIfkeaeeNAPSIIFIDEIDAIAPKREE 289
44 PHA02544
clamp loader, small subunit; Provisional
 7-127 2.60e-05

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 45.37  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   7 TESDLEF--ENKIRPQEL----------ETFSGqdkIVDNLHIfikaalmrgdslDHVLLHGP-PGLGKTTLANIIANEM 73
Cdd:PHA02544    3 TVNPNEFmwEQKYRPSTIdecilpaadkETFKS---IVKKGRI------------PNMLLHSPsPGTGKTTVAKALCNEV 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1681981610  74 HAQLRVTSGP------VLDKPGDLAGLLTNLNPGDVLFIDEIHRLS-PIVEEYLYSAMEDY 127
Cdd:PHA02544   68 GAEVLFVNGSdcridfVRNRLTRFASTVSLTGGGKVIIIDEFDRLGlADAQRHLRSFMEAY 128
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
27-202 3.73e-05

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 44.49  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  27 GQDKIVDNLHIFIKAaLMRGDSLD--------HVLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVLDKP--GDLAGLLT 96
Cdd:COG1223     6 GQEEAKKKLKLIIKE-LRRRENLRkfglwpprKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSylGETARNLR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  97 NL------NPGdVLFIDEIHRL-------------SPIVEEYLySAMEDYKIDIVldkgpsarsiqielapftLIGATTR 157
Cdd:COG1223    85 KLfdfarrAPC-VIFFDEFDAIakdrgdqndvgevKRVVNALL-QELDGLPSGSV------------------VIAATNH 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1681981610 158 SGLLTSPLRARFGIQCHLEYYDAPVLAGIVRRSARILDVSIDDDA 202
Cdd:COG1223   145 PELLDSALWRRFDEVIEFPLPDKEERKEILELNLKKFPLPFELDL 189
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
28-134 4.00e-05

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 44.58  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  28 QDKIVDNLhifiKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVLDKPGDLAGLLTN-----LNP-- 100
Cdd:COG0470     1 QEEAWEQL----LAAAESGRLPHALLLHGPPGIGKTTLALALARDLLCENPEGGKACGQCHSRLMAAGNHpdlleLNPee 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1681981610 101 -GDVLFIDEIHRLSPIVeeYLYSAMEDYKIdIVLD 134
Cdd:COG0470    77 kSDQIGIDQIRELGEFL--SLTPLEGGRKV-VIID 108
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 52-85 8.10e-05

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 42.50  E-value: 8.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVL 85
Cdd:cd19528    30 VLFYGPPGCGKTLLAKAIANECQANFISVKGPEL 63
DEXXQc_SF1 cd18043
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ...
 28-108 9.21e-05

DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350801 [Multi-domain]  Cd Length: 127  Bit Score: 41.41  E-value: 9.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  28 QDKIVDNLhifikaalMRGDSldhVLLHGPPGLGKT-TLANIIAN------------EMHAQLRVTSGPVLDKPGDLAGL 94
Cdd:cd18043     4 QEAAIISA--------RNGKN---VVIQGPPGTGKSqTIANIIANalargkrvlfvsEKKAALDVVRFPCWIMSPLSVSQ 72

                          90
                  ....*....|....*.
gi 1681981610  95 LTNLNPG--DVLFIDE 108
Cdd:cd18043    73 YLPLNRNlfDLVIFDE 88
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 52-109 1.56e-04

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 43.22  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQ-LRVTSGPVLDK-PGDLAGLLTNL------NPGDVLFIDEI 109
Cdd:PTZ00361  220 VILYGPPGTGKTLLAKAVANETSATfLRVVGSELIQKyLGDGPKLVRELfrvaeeNAPSIVFIDEI 285
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 52-109 2.98e-04

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 40.78  E-value: 2.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQ-LRVTSGPVLDK-PGDLAGLLTNL------NPGDVLFIDEI 109
Cdd:cd19502    40 VLLYGPPGTGKTLLAKAVANHTDATfIRVVGSELVQKyIGEGARLVRELfemareKAPSIIFIDEI 105
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 52-75 3.60e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 42.13  E-value: 3.60e-04
                          10        20
                  ....*....|....*....|....
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHA 75
Cdd:PRK03992  168 VLLYGPPGTGKTLLAKAVAHETNA 191
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 52-112 3.87e-04

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 40.41  E-value: 3.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQ-LRVTSGPVLDKP-GDLAGLLTNL------NPGDVLFIDEIHRL 112
Cdd:cd19509    35 ILLYGPPGTGKTLLARAVASESGSTfFSISASSLVSKWvGESEKIVRALfalareLQPSIIFIDEIDSL 103
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 30-72 4.05e-04

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 41.81  E-value: 4.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1681981610  30 KIVDNLHIFIKAALMRGDSLdhvLLHGPPGLGKTTLANIIANE 72
Cdd:PRK06835  167 KILEKCKNFIENFDKNNENL---LFYGNTGTGKTFLSNCIAKE 206
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 52-85 7.18e-04

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 39.79  E-value: 7.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVL 85
Cdd:cd19529    30 ILLYGPPGTGKTLLAKAVATESNANFISVKGPEL 63
PRK14969 PRK14969
DNA polymerase III subunits gamma and tau; Provisional
 16-83 7.91e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237873 [Multi-domain]  Cd Length: 527  Bit Score: 41.27  E-value: 7.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1681981610  16 KIRPQELETFSGQDKIVDNLhifIKAalMRGDSLDHV-LLHGPPGLGKTTLANIIANEMHAQLRVTSGP 83
Cdd:PRK14969    9 KWRPKSFSELVGQEHVVRAL---TNA--LEQQRLHHAyLFTGTRGVGKTTLARILAKSLNCETGVTATP 72
PRK06647 PRK06647
DNA polymerase III subunits gamma and tau; Validated
 16-238 1.19e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235845 [Multi-domain]  Cd Length: 563  Bit Score: 40.52  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  16 KIRPQELETFSGQDKIVDNLhifiKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVLDKPGdlAGLL 95
Cdd:PRK06647    9 KRRPRDFNSLEGQDFVVETL----KHSIESNKIANAYIFSGPRGVGKTSSARAFARCLNCVNGPTPMPCGECSS--CKSI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  96 TNLNPGDVLFID-----EIHRLSPIVEEYLYS-AMEDYK---IDIVLDKGPSA-----RSIQiELAPF-TLIGATTRSGL 160
Cdd:PRK06647   83 DNDNSLDVIEIDgasntSVQDVRQIKEEIMFPpASSRYRvyiIDEVHMLSNSAfnallKTIE-EPPPYiVFIFATTEVHK 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1681981610 161 LTSPLRARFGiQCHLEYYDAPVLAGIVRRSARILDVSIDDDAAHEVALRSRGTPRIANALLRRVRDFAmvkgEGHIDL 238
Cdd:PRK06647  162 LPATIKSRCQ-HFNFRLLSLEKIYNMLKKVCLEDQIKYEDEALKWIAYKSTGSVRDAYTLFDQVVSFS----DSDITL 234
PRK07133 PRK07133
DNA polymerase III subunits gamma and tau; Validated
 11-71 1.22e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235943 [Multi-domain]  Cd Length: 725  Bit Score: 40.57  E-value: 1.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1681981610  11 LEFENKIRPQELETFSGQDKIVDNLHIFIKAalmrgDSLDHV-LLHGPPGLGKTTLANIIAN 71
Cdd:PRK07133    6 KALYRKYRPKTFDDIVGQDHIVQTLKNIIKS-----NKISHAyLFSGPRGTGKTSVAKIFAN 62
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 52-85 1.23e-03

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 39.01  E-value: 1.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVL 85
Cdd:cd19530    33 VLLYGPPGCGKTLLAKAVANESGANFISVKGPEL 66
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 52-165 1.65e-03

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 40.28  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGP-VLDK-PGDLAGLLTNL------NPGDVLFIDEIHRLSPIVEEYLYSA 123
Cdd:TIGR01243 490 VLLFGPPGTGKTLLAKAVATESGANFIAVRGPeILSKwVGESEKAIREIfrkarqAAPAIIFFDEIDAIAPARGARFDTS 569

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1681981610 124 MEDYKIDIVLDKGPSArsiqIELAPFTLIGATTRSGLLTSPL 165
Cdd:TIGR01243 570 VTDRIVNQLLTEMDGI----QELSNVVVIAATNRPDILDPAL 607
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 52-84 1.67e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 37.20  E-value: 1.67e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGPV 84
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARALLKKLGLPKDSV 33
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 52-112 1.78e-03

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 38.69  E-value: 1.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQ-LRVTSGPVLDK-PGDLAGLLTNL------NPGDVLFIDEIHRL 112
Cdd:cd19521    43 ILLYGPPGTGKSYLAKAVATEANSTfFSVSSSDLVSKwMGESEKLVKQLfamareNKPSIIFIDEVDSL 111
NB-ARC pfam00931
NB-ARC domain;
39-72 2.50e-03

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 38.90  E-value: 2.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1681981610  39 IKAALMRGDSLDHVLLHGPPGLGKTTLANIIANE 72
Cdd:pfam00931   8 VIGKLSEKDEPGIVGIHGMGGVGKTTLAAQIFND 41
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 52-169 2.87e-03

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 37.94  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGPVLDKPGDLAG--------LLTNLNPGDVLFIDEIHRLSP--IVEEYLY 121
Cdd:cd19523    36 ILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGekilqasfLAARCRQPSVLFISDLDALLSsqDDEASPV 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1681981610 122 SAMEDyKIDIVLDKGPSARSIQIelapfTLIGATTRSGLLTSPLRARF 169
Cdd:cd19523   116 GRLQV-ELLAQLDGVLGSGEDGV-----LVVCTTSKPEEIDESLRRYF 157
AAA_22 pfam13401
AAA domain;
51-133 2.97e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 37.32  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  51 HVLLHGPPGLGKTTLANIIANEMHA----QLRVT-----------------SGPVLDKPGDLAGLLTNLN-------PGD 102
Cdd:pfam13401   7 ILVLTGESGTGKTTLLRRLLEQLPEvrdsVVFVDlpsgtspkdllrallraLGLPLSGRLSKEELLAALQqlllalaVAV 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1681981610 103 VLFIDEIHRLSPIVEEYLYSAMEDYKIDIVL 133
Cdd:pfam13401  87 VLIIDEAQHLSLEALEELRDLLNLSSKLLQL 117
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 31-109 3.31e-03

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 37.72  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  31 IVDNLHIFIKAAL---------MRGdsldhVLLHGPPGLGKTTLANIIANEMHAQ---LRVTSGPVLDKpgDLAGLLTNL 98
Cdd:cd19510     1 IIDDLKDFIKNEDwyndrgipyRRG-----YLLYGPPGTGKSSFIAALAGELDYDicdLNLSEVVLTDD--RLNHLLNTA 73

                          90
                  ....*....|.
gi 1681981610  99 NPGDVLFIDEI 109
Cdd:cd19510    74 PKQSIILLEDI 84
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 52-109 4.46e-03

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 37.40  E-value: 4.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQ---LRVTSgpVLDK-PGD-------LAGLLTNLNPGdVLFIDEI 109
Cdd:cd19520    38 VLLYGPPGCGKTMLAKATAKEAGARfinLQVSS--LTDKwYGEsqklvaaVFSLASKLQPS-IIFIDEI 103
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
52-151 4.93e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 38.39  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTsgpvLDKPGD-----------LAGLLTNLNPGDVLFIDEIHRLsPIVEEYL 120
Cdd:COG1373    23 VVITGPRQVGKTTLLKQLAKELENILYIN----LDDPRLralaeedpddlLEALKELYPGKTYLFLDEIQRV-PEWEDAL 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1681981610 121 YSAMEDYK-IDIVL-------DKGPSA-----RSIQIELAPFTL 151
Cdd:COG1373    98 KRLVDDGRnGRFILtgsssllLSKELAeslagRIESLELYPLSF 141
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
19-70 6.00e-03

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 37.86  E-value: 6.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1681981610  19 PQELETFSGQDKIVDNLhifiKAALmRGDSLDHV-LLHGPPGLGKTTLANIIA 70
Cdd:COG2812     6 PQTFDDVVGQEHVVRTL----KNAL-ASGRLAHAyLFTGPRGVGKTTLARILA 53
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 52-87 6.04e-03

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 37.02  E-value: 6.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1681981610  52 VLLHGPPGLGKTTLANIIANEMHAQLRVTSGP-VLDK 87
Cdd:cd19526    30 ILLYGPPGCGKTLLASAIASECGLNFISVKGPeLLNK 66
Rad17 pfam03215
Rad17 P-loop domain;
8-90 6.61e-03

Rad17 P-loop domain;


Pssm-ID: 367398 [Multi-domain]  Cd Length: 186  Bit Score: 37.25  E-value: 6.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610   8 ESDLEFE---NKIRPQELETFSGQDKIVDNLHIFIKAALMRGDSLDHVLLHGPPGLGKTTLANIIANEMHAQLRVTSGPV 84
Cdd:pfam03215   1 INDDGGEqwyEKYKPNCLEQLAVHKRKIKDVQEWLDAMFLENAKHRILLISGPSGCGKSTVIKELSKELGPKYREWSNPT 80


                  ....*.
gi 1681981610  85 LDKPGD 90
Cdd:pfam03215  81 SFRSPP 86
PLN03025 PLN03025
replication factor C subunit; Provisional
 16-73 7.01e-03

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 37.79  E-value: 7.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1681981610  16 KIRPQELETFSGQDKIVDNLhifikAALMRGDSLDHVLLHGPPGLGKTTLANIIANEM 73
Cdd:PLN03025    6 KYRPTKLDDIVGNEDAVSRL-----QVIARDGNMPNLILSGPPGTGKTTSILALAHEL 58
DEXXQc_SMUBP2 cd18044
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ...
 39-79 8.50e-03

DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350802 [Multi-domain]  Cd Length: 191  Bit Score: 36.82  E-value: 8.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1681981610  39 IKAALMRGDSldhVLLHGPPGLGKT-TLANIIANEMHAQLRV 79
Cdd:cd18044    10 VKFALSQKDV---ALIHGPPGTGKTtTVVEIILQAVKRGEKV 48
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 22-131 8.70e-03

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 37.32  E-value: 8.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681981610  22 LETFSGQDKIVDNLHifikaaLMRGDSldHVLLHGPPGLGKTTLANIIANEMH----AQLRVTSGPVL------DKPGD- 90
Cdd:cd17706    22 LQLFGGVQKILEDGT------RIRGDI--HILLVGDPGTAKSQILKYVLKIAPrgvyTSGKGSSGAGLtaavvrDSETGe 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1681981610  91 ---LAGLLTnLNPGDVLFIDEIHRLSPIVEEYLYSAMEDYKIDI 131
Cdd:cd17706    94 wylEAGALV-LADGGVCCIDEFDKMKELDRTALHEAMEQQTISI 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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