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NAD(P)H nitroreductase [Bacteroides uniformis]
NfnB family protein( domain architecture ID 10002498)
NfnB family protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
NfnB | COG0778 | Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
40-206 | 1.97e-39 | ||||
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation : Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 133.05 E-value: 1.97e-39
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Name | Accession | Description | Interval | E-value | ||||
NfnB | COG0778 | Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
40-206 | 1.97e-39 | ||||
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 133.05 E-value: 1.97e-39
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PnbA_NfnB-like | cd02136 | nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ... |
43-206 | 1.43e-33 | ||||
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone. Pssm-ID: 380313 [Multi-domain] Cd Length: 152 Bit Score: 117.69 E-value: 1.43e-33
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Nitroreductase | pfam00881 | Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ... |
44-196 | 7.99e-31 | ||||
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds. Pssm-ID: 425926 [Multi-domain] Cd Length: 168 Bit Score: 110.94 E-value: 7.99e-31
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PRK10765 | PRK10765 | oxygen-insensitive NADPH nitroreductase; |
38-211 | 2.51e-11 | ||||
oxygen-insensitive NADPH nitroreductase; Pssm-ID: 182710 Cd Length: 240 Bit Score: 61.14 E-value: 2.51e-11
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Name | Accession | Description | Interval | E-value | ||||
NfnB | COG0778 | Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
40-206 | 1.97e-39 | ||||
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 133.05 E-value: 1.97e-39
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PnbA_NfnB-like | cd02136 | nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ... |
43-206 | 1.43e-33 | ||||
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone. Pssm-ID: 380313 [Multi-domain] Cd Length: 152 Bit Score: 117.69 E-value: 1.43e-33
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nitroreductase | cd02151 | nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
42-205 | 1.88e-31 | ||||
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.. Pssm-ID: 380326 [Multi-domain] Cd Length: 157 Bit Score: 112.24 E-value: 1.88e-31
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Nitroreductase | pfam00881 | Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ... |
44-196 | 7.99e-31 | ||||
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds. Pssm-ID: 425926 [Multi-domain] Cd Length: 168 Bit Score: 110.94 E-value: 7.99e-31
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nitroreductase_FeS-like | cd02143 | nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ... |
44-213 | 4.03e-28 | ||||
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule. Pssm-ID: 380319 [Multi-domain] Cd Length: 187 Bit Score: 104.48 E-value: 4.03e-28
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nitroreductase | cd02150 | nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
44-206 | 6.50e-28 | ||||
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers. Pssm-ID: 380325 [Multi-domain] Cd Length: 156 Bit Score: 103.06 E-value: 6.50e-28
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Nitro_FMN_reductase | cd02062 | nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
44-196 | 2.30e-26 | ||||
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase. Pssm-ID: 380311 [Multi-domain] Cd Length: 139 Bit Score: 98.52 E-value: 2.30e-26
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nitroreductase | cd20608 | nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
42-196 | 1.95e-24 | ||||
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase. Pssm-ID: 380329 [Multi-domain] Cd Length: 145 Bit Score: 93.94 E-value: 1.95e-24
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nitroreductase | cd02139 | nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
40-206 | 1.56e-23 | ||||
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Pssm-ID: 380316 [Multi-domain] Cd Length: 165 Bit Score: 92.15 E-value: 1.56e-23
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nitroreductase | cd20610 | nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
44-196 | 5.48e-22 | ||||
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase. Pssm-ID: 380331 [Multi-domain] Cd Length: 167 Bit Score: 88.10 E-value: 5.48e-22
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nitroreductase | cd20609 | nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
39-196 | 1.87e-20 | ||||
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers. Pssm-ID: 380330 [Multi-domain] Cd Length: 145 Bit Score: 83.59 E-value: 1.87e-20
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NfsA-like | cd02146 | nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ... |
40-206 | 4.52e-19 | ||||
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor. Pssm-ID: 380322 [Multi-domain] Cd Length: 229 Bit Score: 81.90 E-value: 4.52e-19
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MhqN-like | cd02137 | nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ... |
42-206 | 1.35e-17 | ||||
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Pssm-ID: 380314 [Multi-domain] Cd Length: 147 Bit Score: 76.12 E-value: 1.35e-17
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YdjA-like | cd02135 | nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ... |
41-196 | 5.56e-15 | ||||
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase. Pssm-ID: 380312 [Multi-domain] Cd Length: 162 Bit Score: 69.55 E-value: 5.56e-15
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PRK10765 | PRK10765 | oxygen-insensitive NADPH nitroreductase; |
38-211 | 2.51e-11 | ||||
oxygen-insensitive NADPH nitroreductase; Pssm-ID: 182710 Cd Length: 240 Bit Score: 61.14 E-value: 2.51e-11
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TM1586_NiRdase | pfam14512 | Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ... |
39-210 | 6.22e-11 | ||||
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site. Pssm-ID: 405236 [Multi-domain] Cd Length: 214 Bit Score: 59.61 E-value: 6.22e-11
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NfsB-like | cd02149 | nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ... |
39-206 | 1.36e-10 | ||||
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs. Pssm-ID: 380324 [Multi-domain] Cd Length: 156 Bit Score: 57.65 E-value: 1.36e-10
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nitroreductase | cd03370 | uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ... |
40-91 | 1.79e-08 | ||||
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Pssm-ID: 380327 [Multi-domain] Cd Length: 191 Bit Score: 52.32 E-value: 1.79e-08
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TdsD-like | cd02138 | nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ... |
44-199 | 1.12e-07 | ||||
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Pssm-ID: 380315 [Multi-domain] Cd Length: 174 Bit Score: 49.85 E-value: 1.12e-07
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iodotyrosine_dehalogenase | cd02144 | iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ... |
40-199 | 6.97e-07 | ||||
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers. Pssm-ID: 380320 Cd Length: 192 Bit Score: 47.92 E-value: 6.97e-07
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PRK14851 | PRK14851 | hypothetical protein; Provisional |
40-155 | 1.08e-03 | ||||
hypothetical protein; Provisional Pssm-ID: 184853 [Multi-domain] Cd Length: 679 Bit Score: 39.46 E-value: 1.08e-03
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McbC_SagB-like_oxidoreductase | cd02142 | oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain ... |
33-162 | 2.84e-03 | ||||
oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides. Pssm-ID: 380318 Cd Length: 200 Bit Score: 37.40 E-value: 2.84e-03
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