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Conserved domains on  [gi|1434511701|dbj|BBF73164|]
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IS30 family transposase [Lacticaseibacillus paracasei]

Protein Classification

transposase( domain architecture ID 11458135)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
2-227 6.54e-68

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


:

Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 211.66  E-value: 6.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701   2 VTEKLNLGWSPEMV-GYAVHCAPH-------TIYHWIYqRQVDFQPSQLFDHGKRHKRKQDLRSRYNQAV---GTSIEMR 70
Cdd:COG2826    84 VEEKLRKKWSPEQIaGRLKREDDPgmrvsheTIYRYIY-AGGLRKDLYRPLRRKRKRRRPRGRTRKRRGKipdRRSISER 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  71 SKSANRRTEKGHLEMDTVRGgRGSKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFP-GPVRSVTVDHGKEFS 149
Cdd:COG2826   163 PAEVEDRAEPGHWEGDLIIG-KRGKSALLTLVERKSRFVILLKLPDKTAESVADALIRLLRKLPaFLRKSITTDNGKEFA 241
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1434511701 150 CDQALTKRYRIPIYFCHAYHPNERGTNERFNRELRYYFPKGTQFDQVSEANIQRATAFINNKPRKCLRWQTPVQAVSK 227
Cdd:COG2826   242 DHKEIEAALGIKVYFADPYSPWQRGTNENTNGLLRQYFPKGTDFSTVTQEELDAIADRLNNRPRKCLGYKTPAEVFAE 319
 
Name Accession Description Interval E-value
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
2-227 6.54e-68

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 211.66  E-value: 6.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701   2 VTEKLNLGWSPEMV-GYAVHCAPH-------TIYHWIYqRQVDFQPSQLFDHGKRHKRKQDLRSRYNQAV---GTSIEMR 70
Cdd:COG2826    84 VEEKLRKKWSPEQIaGRLKREDDPgmrvsheTIYRYIY-AGGLRKDLYRPLRRKRKRRRPRGRTRKRRGKipdRRSISER 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  71 SKSANRRTEKGHLEMDTVRGgRGSKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFP-GPVRSVTVDHGKEFS 149
Cdd:COG2826   163 PAEVEDRAEPGHWEGDLIIG-KRGKSALLTLVERKSRFVILLKLPDKTAESVADALIRLLRKLPaFLRKSITTDNGKEFA 241
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1434511701 150 CDQALTKRYRIPIYFCHAYHPNERGTNERFNRELRYYFPKGTQFDQVSEANIQRATAFINNKPRKCLRWQTPVQAVSK 227
Cdd:COG2826   242 DHKEIEAALGIKVYFADPYSPWQRGTNENTNGLLRQYFPKGTDFSTVTQEELDAIADRLNNRPRKCLGYKTPAEVFAE 319
transpos_IS30 NF033563
IS30 family transposase;
2-214 4.08e-62

IS30 family transposase;


Pssm-ID: 468088 [Multi-domain]  Cd Length: 267  Bit Score: 195.13  E-value: 4.08e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701   2 VTEKLNLGWSPEM-VGYA------VHCAPHTIYHWIYQRQVDF--QPSQLFDHGKRHKRKQDLRSRYNQAVGTSIEMRSK 72
Cdd:NF033563   46 IEHLLRLGWSPEQiAGRLkreekeVSVSHETIYRYIYAGKLGGgkLYRHLRRGGKRRRPRGGKDRRGKIPDGRSIEERPE 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  73 SANRRTEKGHLEMDTVRGGRGsKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFP-GPVRSVTVDHGKEFSCD 151
Cdd:NF033563  126 EVEDRSRFGHWEGDTILGKKH-KSALLTLVERKSRFVILVKLPDKTAESVNKALIKLLKPLPkHLRKSITADNGKEFARH 204
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1434511701 152 QALTKRYRIPIYFCHAYHPNERGTNERFNRELRYYFPKGTQFDQVSEANIQRATAFINNKPRK 214
Cdd:NF033563  205 SEIEEALGIDVYFADPYSPWQRGTNENTNGLLRQYLPKGTDLSEVSQEELDRIENWLNNRPRK 267
transpos_IS481 NF033577
IS481 family transposase; null
70-225 7.19e-08

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 51.82  E-value: 7.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  70 RSKSANRRTEKGH----LEMDTVRGGR---GSKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFPGPVRSVTV 142
Cdd:NF033577  114 RKTGKVKRYERAHpgelWHIDIKKLGRipdVGRLYLHTAIDDHSRFAYAELYPDETAETAADFLRRAFAEHGIPIRRVLT 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701 143 DHGKEFSCDQALTKRY---------RIPiyfchAYHPNERGTNERFNRELRYYFPKGTQFDqvSEANIQRA-TAFI---- 208
Cdd:NF033577  194 DNGSEFRSRAHGFELAlaelgiehrRTR-----PYHPQTNGKVERFHRTLKDEFAYARPYE--SLAELQAAlDEWLhhyn 266
                         170
                  ....*....|....*..
gi 1434511701 209 NNKPRKCLRWQTPVQAV 225
Cdd:NF033577  267 HHRPHSALGGKTPAERF 283
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
81-170 8.99e-07

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 8.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  81 GHLEMDTVRG---GRGSKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFPGPV-RSVTVDHGKEFSCD--QAL 154
Cdd:pfam00665   3 QLWQGDFTYIripGGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGVpLIIHSDNGSEYTSKafREF 82
                          90
                  ....*....|....*.
gi 1434511701 155 TKRYRIPIYFCHAYHP 170
Cdd:pfam00665  83 LKDLGIKPSFSRPGNP 98
 
Name Accession Description Interval E-value
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
2-227 6.54e-68

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 211.66  E-value: 6.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701   2 VTEKLNLGWSPEMV-GYAVHCAPH-------TIYHWIYqRQVDFQPSQLFDHGKRHKRKQDLRSRYNQAV---GTSIEMR 70
Cdd:COG2826    84 VEEKLRKKWSPEQIaGRLKREDDPgmrvsheTIYRYIY-AGGLRKDLYRPLRRKRKRRRPRGRTRKRRGKipdRRSISER 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  71 SKSANRRTEKGHLEMDTVRGgRGSKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFP-GPVRSVTVDHGKEFS 149
Cdd:COG2826   163 PAEVEDRAEPGHWEGDLIIG-KRGKSALLTLVERKSRFVILLKLPDKTAESVADALIRLLRKLPaFLRKSITTDNGKEFA 241
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1434511701 150 CDQALTKRYRIPIYFCHAYHPNERGTNERFNRELRYYFPKGTQFDQVSEANIQRATAFINNKPRKCLRWQTPVQAVSK 227
Cdd:COG2826   242 DHKEIEAALGIKVYFADPYSPWQRGTNENTNGLLRQYFPKGTDFSTVTQEELDAIADRLNNRPRKCLGYKTPAEVFAE 319
transpos_IS30 NF033563
IS30 family transposase;
2-214 4.08e-62

IS30 family transposase;


Pssm-ID: 468088 [Multi-domain]  Cd Length: 267  Bit Score: 195.13  E-value: 4.08e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701   2 VTEKLNLGWSPEM-VGYA------VHCAPHTIYHWIYQRQVDF--QPSQLFDHGKRHKRKQDLRSRYNQAVGTSIEMRSK 72
Cdd:NF033563   46 IEHLLRLGWSPEQiAGRLkreekeVSVSHETIYRYIYAGKLGGgkLYRHLRRGGKRRRPRGGKDRRGKIPDGRSIEERPE 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  73 SANRRTEKGHLEMDTVRGGRGsKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFP-GPVRSVTVDHGKEFSCD 151
Cdd:NF033563  126 EVEDRSRFGHWEGDTILGKKH-KSALLTLVERKSRFVILVKLPDKTAESVNKALIKLLKPLPkHLRKSITADNGKEFARH 204
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1434511701 152 QALTKRYRIPIYFCHAYHPNERGTNERFNRELRYYFPKGTQFDQVSEANIQRATAFINNKPRK 214
Cdd:NF033563  205 SEIEEALGIDVYFADPYSPWQRGTNENTNGLLRQYLPKGTDLSEVSQEELDRIENWLNNRPRK 267
transpos_IS481 NF033577
IS481 family transposase; null
70-225 7.19e-08

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 51.82  E-value: 7.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  70 RSKSANRRTEKGH----LEMDTVRGGR---GSKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFPGPVRSVTV 142
Cdd:NF033577  114 RKTGKVKRYERAHpgelWHIDIKKLGRipdVGRLYLHTAIDDHSRFAYAELYPDETAETAADFLRRAFAEHGIPIRRVLT 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701 143 DHGKEFSCDQALTKRY---------RIPiyfchAYHPNERGTNERFNRELRYYFPKGTQFDqvSEANIQRA-TAFI---- 208
Cdd:NF033577  194 DNGSEFRSRAHGFELAlaelgiehrRTR-----PYHPQTNGKVERFHRTLKDEFAYARPYE--SLAELQAAlDEWLhhyn 266
                         170
                  ....*....|....*..
gi 1434511701 209 NNKPRKCLRWQTPVQAV 225
Cdd:NF033577  267 HHRPHSALGGKTPAERF 283
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
81-170 8.99e-07

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 8.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434511701  81 GHLEMDTVRG---GRGSKAAVLTIVDRVTRLMATTKLENLSQNAVLKGFARLMVDFPGPV-RSVTVDHGKEFSCD--QAL 154
Cdd:pfam00665   3 QLWQGDFTYIripGGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGVpLIIHSDNGSEYTSKafREF 82
                          90
                  ....*....|....*.
gi 1434511701 155 TKRYRIPIYFCHAYHP 170
Cdd:pfam00665  83 LKDLGIKPSFSRPGNP 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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