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Conserved domains on  [gi|2475324648|dbj|BBD38531|]
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trimethylamine methyltransferase [Aminobacter sp. SS-2016]

Protein Classification

trimethylamine methyltransferase family protein( domain architecture ID 10533356)

trimethylamine methyltransferase family protein similar to Desulfitobacterium hafniense glycine betaine methyltransferase that likely methylates a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate for ultimate conversion to carbon dioxide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 36-520 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


:

Pssm-ID: 428852  Cd Length: 502  Bit Score: 821.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648  36 PGTQLTYIKRKVNVYEVLNEEGLALIEKNADTVLEEIGIEFRDDaEALALWKEAGADVKGERVHFPKGLCRELLKTAPSV 115
Cdd:pfam06253  17 ADQSWPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDP-EALELWRAAGADVDGERVRFDRGLVRELLATAPRQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 116 YTQHARNPERSVQIGGDATVFAPVYGPPFVRDLDGNRRYATIEDFRNFVKLAYMAPSIHHSGGTVCEPVDVPVNKRHLDM 195
Cdd:pfam06253  96 FTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLDM 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 196 VYSHIKYSDKPFMGSVTAPERAEDTVAMAKIVFGDDFVEN--NTVLTSLINANSPMVFDETMLGAAKVYARHNQACIVTP 273
Cdd:pfam06253 176 LYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFraNPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVTP 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 274 FILAGAMSPVTVAGTLTQVLAEVLAGASFTQLIRKGAPVLFGTFASSISMQSGAPTFGTPEPTLVSYGAAQLARRLGLPF 353
Cdd:pfam06253 256 FILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLPW 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 354 RTGGSLCASKVPDAQAAYESANTLNSTLLAGTNFVLHSAGWLEGGLASCYEKFMMDIDQLGMQQKFAEGVDLSENGQAMD 433
Cdd:pfam06253 336 RSSGGLTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAMD 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 434 AIRQVGPGSHYLGCDHTQANFQTAFYRSSIADNNSYEQWLAEGQKTAPQRANELARRWLESYEAPYLDPSIDDGLKDFIA 513
Cdd:pfam06253 416 AIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFIA 495


                  ....*..
gi 2475324648 514 AKKASMP 520
Cdd:pfam06253 496 RRKAEGG 502
 
Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 36-520 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 821.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648  36 PGTQLTYIKRKVNVYEVLNEEGLALIEKNADTVLEEIGIEFRDDaEALALWKEAGADVKGERVHFPKGLCRELLKTAPSV 115
Cdd:pfam06253  17 ADQSWPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDP-EALELWRAAGADVDGERVRFDRGLVRELLATAPRQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 116 YTQHARNPERSVQIGGDATVFAPVYGPPFVRDLDGNRRYATIEDFRNFVKLAYMAPSIHHSGGTVCEPVDVPVNKRHLDM 195
Cdd:pfam06253  96 FTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLDM 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 196 VYSHIKYSDKPFMGSVTAPERAEDTVAMAKIVFGDDFVEN--NTVLTSLINANSPMVFDETMLGAAKVYARHNQACIVTP 273
Cdd:pfam06253 176 LYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFraNPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVTP 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 274 FILAGAMSPVTVAGTLTQVLAEVLAGASFTQLIRKGAPVLFGTFASSISMQSGAPTFGTPEPTLVSYGAAQLARRLGLPF 353
Cdd:pfam06253 256 FILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLPW 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 354 RTGGSLCASKVPDAQAAYESANTLNSTLLAGTNFVLHSAGWLEGGLASCYEKFMMDIDQLGMQQKFAEGVDLSENGQAMD 433
Cdd:pfam06253 336 RSSGGLTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAMD 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 434 AIRQVGPGSHYLGCDHTQANFQTAFYRSSIADNNSYEQWLAEGQKTAPQRANELARRWLESYEAPYLDPSIDDGLKDFIA 513
Cdd:pfam06253 416 AIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFIA 495


                  ....*..
gi 2475324648 514 AKKASMP 520
Cdd:pfam06253 496 RRKAEGG 502
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
50-515 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 721.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648  50 YEVLNEEGLALIEKNADTVLEEIGIEFRDDaEALALWKEAGADVKGERVHFPKGLCRELLKTAPSVYTQHARNPERSVQI 129
Cdd:COG5598     3 YEPLSEEQIERIHEAALRILEEIGVEFEHE-EALEIFKKAGARVEGGRVRIPRALVEEALATAPSSFTLYARNPERDVEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 130 GGDATVFAPVYGPPFVRDLD-GNRRYATIEDFRNFVKLAYMAPSIHHSGGTVCEPVDVPVNKRHLDMVYSHIKYSDKPFM 208
Cdd:COG5598    82 GGGNVVFGPGGGAPFVLDLEtGERRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVPVEVRHLDMLYAMLKYTDKPIM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 209 GSVTAPERAEDTVAMAKIVFG-DDFVENNTVLTSLINANSPMVFDETMLGAAKVYARHNQACIVTPFILAGAMSPVTVAG 287
Cdd:COG5598   162 GSATGRERVEDSIEMARIVAGgEEELREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVTLAG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 288 TLTQVLAEVLAGASFTQLIRKGAPVLFGTFASSISMQSGAPTFGTPEPTLVSYGAAQLARRLGLPFRTGGSLCASKVPDA 367
Cdd:COG5598   242 ALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGLTDSKLPDA 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 368 QAAYESANTLNSTLLAGTNFVLHSAGWLEGGLASCYEKFMMDIDQLGMQQKFAEGVDLSENGQAMDAIRQVGPGSHYLGC 447
Cdd:COG5598   322 QAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPGGHFLGH 401

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2475324648 448 DHTQANFQTAFYRSSIADNNSYEQWLAEGQKTAPQRANELARRWLESYEAPYLDPSIDDGLKDFIAAK 515
Cdd:COG5598   402 PHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 36-520 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 821.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648  36 PGTQLTYIKRKVNVYEVLNEEGLALIEKNADTVLEEIGIEFRDDaEALALWKEAGADVKGERVHFPKGLCRELLKTAPSV 115
Cdd:pfam06253  17 ADQSWPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDP-EALELWRAAGADVDGERVRFDRGLVRELLATAPRQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 116 YTQHARNPERSVQIGGDATVFAPVYGPPFVRDLDGNRRYATIEDFRNFVKLAYMAPSIHHSGGTVCEPVDVPVNKRHLDM 195
Cdd:pfam06253  96 FTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLDM 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 196 VYSHIKYSDKPFMGSVTAPERAEDTVAMAKIVFGDDFVEN--NTVLTSLINANSPMVFDETMLGAAKVYARHNQACIVTP 273
Cdd:pfam06253 176 LYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFraNPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVTP 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 274 FILAGAMSPVTVAGTLTQVLAEVLAGASFTQLIRKGAPVLFGTFASSISMQSGAPTFGTPEPTLVSYGAAQLARRLGLPF 353
Cdd:pfam06253 256 FILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLPW 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 354 RTGGSLCASKVPDAQAAYESANTLNSTLLAGTNFVLHSAGWLEGGLASCYEKFMMDIDQLGMQQKFAEGVDLSENGQAMD 433
Cdd:pfam06253 336 RSSGGLTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAMD 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 434 AIRQVGPGSHYLGCDHTQANFQTAFYRSSIADNNSYEQWLAEGQKTAPQRANELARRWLESYEAPYLDPSIDDGLKDFIA 513
Cdd:pfam06253 416 AIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFIA 495


                  ....*..
gi 2475324648 514 AKKASMP 520
Cdd:pfam06253 496 RRKAEGG 502
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
50-515 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 721.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648  50 YEVLNEEGLALIEKNADTVLEEIGIEFRDDaEALALWKEAGADVKGERVHFPKGLCRELLKTAPSVYTQHARNPERSVQI 129
Cdd:COG5598     3 YEPLSEEQIERIHEAALRILEEIGVEFEHE-EALEIFKKAGARVEGGRVRIPRALVEEALATAPSSFTLYARNPERDVEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 130 GGDATVFAPVYGPPFVRDLD-GNRRYATIEDFRNFVKLAYMAPSIHHSGGTVCEPVDVPVNKRHLDMVYSHIKYSDKPFM 208
Cdd:COG5598    82 GGGNVVFGPGGGAPFVLDLEtGERRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVPVEVRHLDMLYAMLKYTDKPIM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 209 GSVTAPERAEDTVAMAKIVFG-DDFVENNTVLTSLINANSPMVFDETMLGAAKVYARHNQACIVTPFILAGAMSPVTVAG 287
Cdd:COG5598   162 GSATGRERVEDSIEMARIVAGgEEELREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVTLAG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 288 TLTQVLAEVLAGASFTQLIRKGAPVLFGTFASSISMQSGAPTFGTPEPTLVSYGAAQLARRLGLPFRTGGSLCASKVPDA 367
Cdd:COG5598   242 ALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGLTDSKLPDA 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2475324648 368 QAAYESANTLNSTLLAGTNFVLHSAGWLEGGLASCYEKFMMDIDQLGMQQKFAEGVDLSENGQAMDAIRQVGPGSHYLGC 447
Cdd:COG5598   322 QAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPGGHFLGH 401

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2475324648 448 DHTQANFQTAFYRSSIADNNSYEQWLAEGQKTAPQRANELARRWLESYEAPYLDPSIDDGLKDFIAAK 515
Cdd:COG5598   402 PHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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