NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1031984628|dbj|BAV10029|]
View 

response regulator receiver protein [Filimonas lacunae]

Protein Classification

response regulator( domain architecture ID 139559)

response regulator receives the signal from a sensor partner in two-component systems through its receiver (REC) domain

Gene Ontology:  GO:0000160
PubMed:  31100988

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
REC super family cl19078
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 11-134 2.67e-23

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


The actual alignment was detected with superfamily member cd17557:

Pssm-ID: 473134 [Multi-domain]  Cd Length: 129  Bit Score: 87.86  E-value: 2.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDPSWQVVCIPNGRKFVSYL---DTIQDKDLPALLVLDYNIPELTGVEVVKELNNHSRYQ 87
Cdd:cd17557     2 ILLVEDNPGDAELIQEAFKEAGVPNELHVVRDGEEALDFLrgeGEYADAPRPDLILLDLNMPRMDGFEVLREIKADPDLR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1031984628  88 EIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYMLSF 134
Cdd:cd17557    82 RIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSLGEY 128
 
Name Accession Description Interval E-value
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 11-134 2.67e-23

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 87.86  E-value: 2.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDPSWQVVCIPNGRKFVSYL---DTIQDKDLPALLVLDYNIPELTGVEVVKELNNHSRYQ 87
Cdd:cd17557     2 ILLVEDNPGDAELIQEAFKEAGVPNELHVVRDGEEALDFLrgeGEYADAPRPDLILLDLNMPRMDGFEVLREIKADPDLR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1031984628  88 EIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYMLSF 134
Cdd:cd17557    82 RIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSLGEY 128
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 11-118 1.26e-20

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 82.26  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRYQEIP 90
Cdd:COG3706     4 ILVVDDDPTNRKLLRRLLEAAG--YEVVEAADGEEALELLQEHR----PDLILLDLEMPDMDGLELCRRLRADPRTADIP 77

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:COG3706    78 IIFLTALDDEEDRARALEAGADDYLTKP 105
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 11-129 4.67e-10

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 53.31  E-value: 4.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidpSWQVVCI-PNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNNHSryQEI 89
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEK---EGYVVAEaDDGKEALELLK----EERPDLILLDINMPGMDGLELLKRIRRRD--PTT 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1031984628  90 PKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAK 129
Cdd:pfam00072  72 PVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
11-120 1.27e-09

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 54.04  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDD----SDDQELLESAfgeidpSWQVVCIPNGRKFVSYLDTIQDkdlpaLLVLDYNIPELTGVEVVKELNNHsry 86
Cdd:PRK10955    4 ILLVDDDreltSLLKELLEME------GFNVIVAHDGEQALDLLDDSID-----LLLLDVMMPKKNGIDTLKELRQT--- 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1031984628  87 QEIPKIIWSTSSSPVFKAMSMELGAADYITKP-ND 120
Cdd:PRK10955   70 HQTPVIMLTARGSELDRVLGLELGADDYLPKPfND 104
 
Name Accession Description Interval E-value
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 11-134 2.67e-23

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 87.86  E-value: 2.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDPSWQVVCIPNGRKFVSYL---DTIQDKDLPALLVLDYNIPELTGVEVVKELNNHSRYQ 87
Cdd:cd17557     2 ILLVEDNPGDAELIQEAFKEAGVPNELHVVRDGEEALDFLrgeGEYADAPRPDLILLDLNMPRMDGFEVLREIKADPDLR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1031984628  88 EIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYMLSF 134
Cdd:cd17557    82 RIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSLGEY 128
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 11-118 1.26e-20

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 82.26  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRYQEIP 90
Cdd:COG3706     4 ILVVDDDPTNRKLLRRLLEAAG--YEVVEAADGEEALELLQEHR----PDLILLDLEMPDMDGLELCRRLRADPRTADIP 77

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:COG3706    78 IIFLTALDDEEDRARALEAGADDYLTKP 105
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 8-131 1.54e-20

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 80.66  E-value: 1.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628   8 NRLILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNNHSRYQ 87
Cdd:COG0784     5 GKRILVVDDNPDNRELLRRLLERLG--YEVTTAEDGAEALELLR----AGPPDLILLDINMPGMDGLELLRRIRALPRLP 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1031984628  88 EIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFL-TIAKYM 131
Cdd:COG0784    79 DIPIIALTAYADEEDRERALEAGADDYLTKPVDPEELLeALRRLL 123
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 8-133 2.53e-18

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 77.51  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628   8 NRLILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNNHSRYQ 87
Cdd:COG3437     6 APTVLIVDDDPENLELLRQLLRTLG--YDVVTAESGEEALELLL----EAPPDLILLDVRMPGMDGFELLRLLRADPSTR 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1031984628  88 EIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYMLS 133
Cdd:COG3437    80 DIPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALE 125
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 11-118 1.92e-16

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 71.91  E-value: 1.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELnnHSRYQEIP 90
Cdd:COG0745     4 ILVVEDDPDIRELLADALEREG--YEVDTAADGEEALELLEEER----PDLILLDLMLPGMDGLEVCRRL--RARPSDIP 75

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:COG0745    76 IIMLTARDDEEDRVRGLEAGADDYLTKP 103
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 11-120 1.18e-14

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 69.22  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELnnHSRYQEIP 90
Cdd:COG2204     5 ILVVDDDPDIRRLLKELLERAG--YEVETAASGEEALALLREEP----PDLVLLDLRMPGMDGLELLREL--RALDPDLP 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPND 120
Cdd:COG2204    77 VILLTGYGDVETAVEAIKAGAFDYLTKPFD 106
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 12-118 1.55e-14

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 64.56  E-value: 1.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  12 LLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELnnHSRYQEIPK 91
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREG--YEVDTAADGEEALELLREER----PDLVLLDLMMPGMDGLELLRKL--RELPPDIPV 72

                          90       100
                  ....*....|....*....|....*..
gi 1031984628  92 IIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd00156    73 IVLTAKADEEDAVRALELGADDYLVKP 99
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 11-137 6.07e-13

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 61.52  E-value: 6.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDPSWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHsrYQEIP 90
Cdd:COG4565     6 VLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHR----PDLILLDIYLPDGDGLELLRELRAR--GPDVD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYMLSFVKA 137
Cdd:COG4565    80 VIVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRL 126
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 11-118 8.82e-12

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 58.03  E-value: 8.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLesAFGEIDPSWQVVCIPNGRKFVSYLDTIqdkdLPALLVLDYNIPELTGVEVVKELNNHSRYQEIP 90
Cdd:cd17618     3 ILIVEDEPAIREMI--AFNLERAGFDVVEAEDAESAVNLIVEP----RPDLILLDWMLPGGSGIQFIRRLKRDEMTRDIP 76

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17618    77 IIMLTARGEEEDKVRGLEAGADDYITKP 104
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 12-118 9.54e-12

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 57.67  E-value: 9.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  12 LLAEDDSDDQELLEsaFGEIDPSWQVVCIPNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNNHSRYQEIPK 91
Cdd:cd19937     1 LVVDDEEDIVELLK--YNLEKEGYEVVTAYDGEEALKRAK----DEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSIPI 74

                          90       100
                  ....*....|....*....|....*..
gi 1031984628  92 IIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19937    75 IMLTAKGEEFDKVLGLELGADDYITKP 101
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 11-118 2.74e-11

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 56.32  E-value: 2.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDPsWQVVCI-PNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELnnHSRYQEI 89
Cdd:COG4753     2 VLIVDDEPLIREGLKRILEWEAG-FEVVGEaENGEEALELLEEHK----PDLVITDINMPGMDGLELLEAI--RELDPDT 74

                          90       100
                  ....*....|....*....|....*....
gi 1031984628  90 PKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:COG4753    75 KIIILSGYSDFEYAQEAIKLGADDYLLKP 103
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 11-118 3.50e-11

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 56.28  E-value: 3.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLEsaFGEIDPSWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSryqEIP 90
Cdd:cd17614     1 ILVVDDEKPISDILK--FNLTKEGYEVVTAYDGREALEKVEEEQ----PDLILLDLMLPEKDGLEVCREVRKTS---NVP 71

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17614    72 IIMLTAKDSEVDKVLGLELGADDYVTKP 99
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 11-126 3.62e-11

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 56.30  E-value: 3.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIdPSWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRYQEIP 90
Cdd:cd17551     3 ILIVDDNPTNLLLLEALLRSA-GYLEVVSFTDPREALAWCRENP----PDLILLDYMMPGMDGLEFIRRLRALPGLEDVP 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLT 126
Cdd:cd17551    78 IVMITADTDREVRLRALEAGATDFLTKPFDPVELLA 113
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 12-118 1.01e-10

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 54.72  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  12 LLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRyqEIPK 91
Cdd:cd17574     1 LVVEDDEEIAELLSDYLEKEG--YEVDTAADGEEALELAREEQ----PDLIILDVMLPGMDGFEVCRRLREKGS--DIPI 72

                          90       100
                  ....*....|....*....|....*..
gi 1031984628  92 IIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17574    73 IMLTAKDEEEDKVLGLELGADDYITKP 99
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 11-133 3.45e-10

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 53.87  E-value: 3.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNNHSRYQEIP 90
Cdd:cd17598     1 ILIVEDSPTQAEQLKHILEE--QGYKVQVARNGREALAMLA----EHRPTLVISDIVMPEMDGYELCRKIKSDPDLKDIP 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYMLS 133
Cdd:cd17598    75 VILLTTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYILV 117
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 61-129 4.63e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 53.46  E-value: 4.63e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1031984628  61 LLVLDYNIPELTGVEVVKELNNHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAK 129
Cdd:cd17562    47 LIITDQNMPNMDGIELIKELRKLPAYKFTPILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVK 115
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 11-129 4.67e-10

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 53.31  E-value: 4.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidpSWQVVCI-PNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNNHSryQEI 89
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEK---EGYVVAEaDDGKEALELLK----EERPDLILLDINMPGMDGLELLKRIRRRD--PTT 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1031984628  90 PKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAK 129
Cdd:pfam00072  72 PVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
 13-118 1.14e-09

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 52.37  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  13 LAEDDSD-DQELLESAFGEidPSWQVVCIPNGRKFVSYLDTIQDKDLPA-------LLVLDYNIPELTGVEVVKELNNHS 84
Cdd:cd17581     2 LAVDDSLvDRKVIERLLRI--SSCRVTAVDSGKRALEFLGLEDEEDSSNfnepkvnMIITDYCMPGMTGYDLLKKVKESS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1031984628  85 RYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17581    80 ALKEIPVVIMSSENIPTRISRCLEEGAEDFLLKP 113
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
11-120 1.27e-09

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 54.04  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDD----SDDQELLESAfgeidpSWQVVCIPNGRKFVSYLDTIQDkdlpaLLVLDYNIPELTGVEVVKELNNHsry 86
Cdd:PRK10955    4 ILLVDDDreltSLLKELLEME------GFNVIVAHDGEQALDLLDDSID-----LLLLDVMMPKKNGIDTLKELRQT--- 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1031984628  87 QEIPKIIWSTSSSPVFKAMSMELGAADYITKP-ND 120
Cdd:PRK10955   70 HQTPVIMLTARGSELDRVLGLELGADDYLPKPfND 104
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 11-118 2.08e-09

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 51.25  E-value: 2.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAE-DDSDDQE---LLESAfgeidpSWQVVCIPNGRKFVSYLDTIQ-DKDLpalLVLDYNIPELTGVEVVKELNNHSR 85
Cdd:cd17582     1 VLLVEnDDSTRQIvtaLLRKC------SYEVTAASDGLQAWDVLEDEQnEIDL---ILTEVDLPVSSGFKLLSYIMRHKI 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1031984628  86 YQEIPKIIWST--SSSPVFKAMSmeLGAADYITKP 118
Cdd:cd17582    72 CKNIPVIMMSSqdSVGVVFKCLS--KGAADYLVKP 104
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 11-122 2.53e-09

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 51.51  E-value: 2.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpsWQVVCIPNgrkFVSYLDTIQDKDlPALLVLDYNIPELTGVEVVKELNNHSryqEIP 90
Cdd:cd18159     1 ILIVEDDETIASLLKKHLEKWG--YEVVLIED---FEDVLEEFLQFK-PDLVLLDINLPYFDGFYWCREIRQIS---NVP 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPNDVA 122
Cdd:cd18159    72 IIFISSRDDNMDQVMAINMGGDDYITKPFDLD 103
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 11-118 6.71e-09

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 50.38  E-value: 6.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNNHSryqEIP 90
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEM--EGFNVRAAHDGEQGLAALL----EGSPDLVVLDVMLPKMNGLDVLKELRKTS---QVP 71

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17623    72 VLMLTARGDDIDRILGLELGADDYLPKP 99
PLN03029 PLN03029
type-a response regulator protein; Provisional
 12-132 1.21e-08

type-a response regulator protein; Provisional


Pssm-ID: 215544 [Multi-domain]  Cd Length: 222  Bit Score: 51.57  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  12 LLAEDDS-DDQELLESAFGeiDPSWQVVCIPNGRKFVSYL----DTIQDKDLPA------------LLVLDYNIPELTGV 74
Cdd:PLN03029   11 VLAVDDSlIDRKLIEKLLK--TSSYQVTTVDSGSKALKFLglheDDRSNPDTPSvspnshqevevnLIITDYCMPGMTGY 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1031984628  75 EVVKELNNHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYML 132
Cdd:PLN03029   89 DLLKKIKESSSLRNIPVVIMSSENVPSRITRCLEEGAEEFFLKPVQLSDLNRLKPHMM 146
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 58-118 1.32e-08

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 49.05  E-value: 1.32e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1031984628  58 LPALLVLDYNIPELTGVEVVKELNNHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19920    42 PPDLILLDVMMPGMDGFEVCRRLKADPATRHIPVIFLTALTDTEDKVKGFELGAVDYITKP 102
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 11-130 2.11e-08

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 50.59  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIdPSWQVV-CIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRyqeI 89
Cdd:COG3279     4 ILIVDDEPLARERLERLLEKY-PDLEVVgEASNGEEALELLEEHK----PDLVFLDIQMPGLDGFELARQLRELDP---P 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1031984628  90 PKIIWSTSSS-PVFKAmsMELGAADYITKPNDVASFL-TIAKY 130
Cdd:COG3279    76 PPIIFTTAYDeYALEA--FEVNAVDYLLKPIDEERLAkALEKA 116
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 11-129 2.75e-08

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 48.54  E-value: 2.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKFvsyLDTIQDKDLpALLVLDYNIPELTGVEVVKELNNHSryqEIP 90
Cdd:cd17619     3 ILIVEDEPVTRATLKSYFEQ--EGYDVSEAGDGEEM---RQILARQDI-DLVLLDINLPGKDGLSLTRELREQS---EVG 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAK 129
Cdd:cd17619    74 IILVTGRDDEVDRIVGLEIGADDYVTKPFNPRELLVRAK 112
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 11-118 3.01e-08

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 48.53  E-value: 3.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNnhsRYQEIP 90
Cdd:cd19938     2 ILIVEDEPKLAQLLIDYLRA--AGYAPTLLAHGDQVLPYVRHTP----PDLILLDLMLPGTDGLTLCREIR---RFSDVP 72

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19938    73 IIMVTARVEEIDRLLGLELGADDYICKP 100
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 11-118 3.53e-08

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 48.26  E-value: 3.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIdpSWQVVCIPNGRkfvSYLDTIQdKDLPALLVLDYNIPELTGVEVVKELNNHSRYQEIP 90
Cdd:cd17538     2 ILVVDDEPANRELLEALLSAE--GYEVLTADSGQ---EALALAE-EELPDLILLDVMMPGMDGFEVCRRLKEDPETRHIP 75

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17538    76 VIMITALDDREDRIRGLEAGADDFLSKP 103
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 11-118 3.73e-08

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 48.14  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIdpSWQVVCIPNGRKFVSYLDTIQD------KDLPaLLVLDYNIPELTGVEVVKELNNHS 84
Cdd:cd19924     1 ILVVDDSPTARKQLRDLLKNL--GFEIAEAVDGEEALNKLENLAKegndlsKELD-LIITDIEMPKMDGYELTFELRDDP 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1031984628  85 RYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19924    78 RLANIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 11-118 8.60e-08

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 47.37  E-value: 8.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFgeIDPSWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSryqEIP 90
Cdd:cd19939     2 ILIVEDELELARLTRDYL--IKAGLEVSVFTDGQRAVRRIIDEQ----PSLVVLDIMLPGMDGLTVCREVREHS---HVP 72

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19939    73 ILMLTARTEEMDRVLGLEMGADDYLCKP 100
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 11-122 1.24e-07

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 46.83  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGeiDPSWQVVCIPNGRKfvsYLDTIQDKDlPALLVLDYNIPELTGVEVVKELNNhsRYQEIP 90
Cdd:cd17554     3 ILVVDDEENIRELYKEELE--DEGYEVVTAGNGEE---ALEKLESED-PDLVILDIKMPGMDGLETLRKIRE--KKPDLP 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1031984628  91 KIIwsTSSSPVFKAMSMELGAADYITKPNDVA 122
Cdd:cd17554    75 VII--CTAYSEYKSDFSSWAADAYVVKSSDLT 104
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 55-118 1.55e-07

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 46.42  E-value: 1.55e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1031984628  55 DKDLPALLVLDYNIPELTGVEVVKELNNHSryqEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17621    39 DRAGADIVLLDLMLPGLSGTEVCRQLRARS---NVPVIMVTAKDSEIDKVVGLELGADDYVTKP 99
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 11-129 2.30e-07

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 46.38  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQEL----LESAfgeidpSWQVVCIPNGRKFVSyldtIQDKDLPALLVLDYNIPELTGVEVVKELNNHSRY 86
Cdd:cd17548     2 ILIVEDNPLNMKLardlLESA------GYEVLEAADGEEALE----IARKEKPDLILMDIQLPGMDGLEATRLLKEDPAT 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1031984628  87 QEIPkIIWSTSSspvfkAM------SMELGAADYITKPNDVASFL-TIAK 129
Cdd:cd17548    72 RDIP-VIALTAY-----AMkgdrekILEAGCDGYISKPIDTREFLeTVAK 115
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 11-128 2.41e-07

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 47.26  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIdpSWQVV-CIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRyqeI 89
Cdd:COG3707     6 VLVVDDEPLRRADLREGLREA--GYEVVaEAADGEDAVELVRELK----PDLVIVDIDMPDRDGLEAARQISEERP---A 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1031984628  90 PKIIWSTSSSPVFKAMSMELGAADYITKP---NDVASFLTIA 128
Cdd:COG3707    77 PVILLTAYSDPELIERALEAGVSAYLVKPldpEDLLPALELA 118
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 11-118 7.10e-07

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 44.46  E-value: 7.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGeiDPSWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRyqeIP 90
Cdd:cd17620     1 ILVIEDEPQIRRFLRTALE--AHGYRVFEAETGQEGLLEAATRK----PDLIILDLGLPDMDGLEVIRRLREWSA---VP 71

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17620    72 VIVLSARDEESDKIAALDAGADDYLTKP 99
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 8-118 7.85e-07

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 44.85  E-value: 7.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628   8 NRLILLAEDDSDDQELLESAFgEIDPSWQVVCIPNGRKFVSYLDTiqdkDLPALLVLDYNIPELTGVEVVKELNNHSRYQ 87
Cdd:cd17552     1 SKRILVIDDEEDIREVVQACL-EKLAGWEVLTASSGQEGLEKAAT----EQPDAILLDVMMPDMDGLATLKKLQANPETQ 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1031984628  88 EIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17552    76 SIPVILLTAKAQPSDRQRFASLGVAGVIAKP 106
PRK15479 PRK15479
transcriptional regulator TctD;
11-122 8.52e-07

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 46.25  E-value: 8.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKfvsyLDTIQDKDLPALLVLDYNIPELTGVEVVKELnnHSRYQEIP 90
Cdd:PRK15479    3 LLLAEDNRELAHWLEKALVQ--NGFAVDCVFDGLA----ADHLLQSEMYALAVLDINMPGMDGLEVLQRL--RKRGQTLP 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPNDVA 122
Cdd:PRK15479   75 VLLLTARSAVADRVKGLNVGADDYLPKPFELE 106
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 11-125 1.55e-06

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 43.91  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKfvsYLDTIQDKDlPALLVLDYNIPELTGVEVVKELNnhsRYQEIP 90
Cdd:cd17622     3 ILLVEDDPKLARLIADFLESHG--FNVVVEHRGDR---ALEVIAREK-PDAVLLDIMLPGIDGLTLCRDLR---PKYQGP 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPNDVASFL 125
Cdd:cd17622    74 ILLLTALDSDIDHILGLELGADDYVVKPVEPAVLL 108
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 36-118 2.19e-06

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 43.66  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  36 QVVCIPNGRKFVSYLDtiQDKDLpALLVLDYNIPELTGVEVVKEL-NNHSRyQEIPKIIWSTSSSPVFKAMSMELGAADY 114
Cdd:cd17544    26 QVLEAANGQEALEVLE--QHPDI-KLVITDYNMPEMDGFELVREIrKKYSR-DQLAIIGISASGDNALSARFIKAGANDF 101


                  ....
gi 1031984628 115 ITKP 118
Cdd:cd17544   102 LTKP 105
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 54-118 2.21e-06

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 44.95  E-value: 2.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1031984628  54 QDKDLPALLVLDYNIPELTGVEVVKELnnHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:PRK11083   43 LRQQPPDLVILDVGLPDISGFELCRQL--LAFHPALPVIFLTARSDEVDRLVGLEIGADDYVAKP 105
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
21-132 2.29e-06

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 45.14  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  21 QELLESafgeiDPSWQVVCI-PNGRKFVsylDTIQdKDLPALLVLDYNIPELTGVEVVKELNNHSRyqeIPKIIWSTS-- 97
Cdd:PRK00742   20 SEILNS-----DPDIEVVGTaPDGLEAR---EKIK-KLNPDVITLDVEMPVMDGLDALEKIMRLRP---TPVVMVSSLte 87

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1031984628  98 --SSPVFKAMsmELGAADYITKP-NDVASFLTIAKYML 132
Cdd:PRK00742   88 rgAEITLRAL--ELGAVDFVTKPfLGISLGMDEYKEEL 123
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 56-123 4.89e-06

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 42.76  E-value: 4.89e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1031984628  56 KDLPALLVLDYNIPELTGVEVVKELNnhsRYQEIPKIIWSTSSSP----VFKAMsmELGAADYITKPNDVAS 123
Cdd:cd17541    44 ELKPDVITLDIEMPVMDGLEALRRIM---AERPTPVVMVSSLTEEgaeiTLEAL--ELGAVDFIAKPSGGIS 110
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
59-118 6.15e-06

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 43.94  E-value: 6.15e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  59 PALLVLDYNIPELTGVEVVKELNNHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:PRK10161   47 PDLILLDWMLPGGSGIQFIKHLKRESMTRDIPVVMLTARGEEEDRVRGLETGADDYITKP 106
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 23-118 6.20e-06

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 42.58  E-value: 6.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  23 LLESAfgeidpSWQVVCIPNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNnhSRYQEIPkIIWSTSSSPVf 102
Cdd:cd17537    19 LLRSV------GLAVKTFTSASAFLAAAP----PDQPGCLVLDVRMPGMSGLELQDELL--ARGSNIP-IIFITGHGDV- 84

                          90
                  ....*....|....*....
gi 1031984628 103 kAMS---MELGAADYITKP 118
Cdd:cd17537    85 -PMAveaMKAGAVDFLEKP 102
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 59-117 1.41e-05

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 41.62  E-value: 1.41e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1031984628  59 PALLVLDYNIPELTGVEVVKELNNHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITK 117
Cdd:cd17575    46 PTVILQDLVMPGVDGLTLVRFFRANPATRDIPIIVLSTKEEPEVKSEAFALGANDYLVK 104
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 59-118 1.47e-05

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 41.20  E-value: 1.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  59 PALLVLDYNIPELTGVEVVKELNNHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17602    43 PDLILIDIDMPDLDGYELCSLLRKSSALKDTPIIMLTGKDGLVDRIRAKMAGASGYLTKP 102
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 11-118 1.67e-05

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 41.21  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFgEIDpSWQVVCIPNGrkfVSYLDTIqDKDLPALLVLDYNIPELTGVEVVKELNNHSRyqEIP 90
Cdd:cd17627     1 ILVVDDDRAVRESLRRSL-RFE-GYEVETAVDG---AEALRVI-SGNRPDAVVLDVMMPRLDGLEVCRRLRAAGN--DLP 72

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17627    73 ILVLTARDSVSDRVAGLDAGADDYLVKP 100
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
9-122 1.72e-05

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 42.91  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628   9 RLILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRYQe 88
Cdd:PRK11361    5 NRILIVDDEDNVRRMLSTAFAL--QGFETHCANNGRTALHLFADIH----PDVVLMDIRMPEMDGIKALKEMRSHETRT- 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1031984628  89 ipKIIWSTSSSPVFKAM-SMELGAADYITKPNDVA 122
Cdd:PRK11361   78 --PVILMTAYAEVETAVeALRCGAFDYVIKPFDLD 110
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 9-122 2.57e-05

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 41.83  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628   9 RLILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELnnHSRYQE 88
Cdd:COG4567     5 RSLLLVDDDEAFARVLARALERRG--FEVTTAASVEEALALLEQAP----PDYAVLDLRLGDGSGLDLIEAL--RERDPD 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1031984628  89 IPKIIWSTSSSP--VFKAMsmELGAADYITKPNDVA 122
Cdd:COG4567    77 ARIVVLTGYASIatAVEAI--KLGADDYLAKPADAD 110
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 11-117 3.09e-05

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 40.57  E-value: 3.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAeddsDDQELLESAFG---EIDPSWQVVCI-PNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELnnHSRY 86
Cdd:cd17535     1 VLIV----DDHPLVREGLRrllESEPDIEVVGEaADGEEALALLRELR----PDVVLMDLSMPGMDGIEALRRL--RRRY 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1031984628  87 QEIPKIIWSTSSSPVFKAMSMELGAADYITK 117
Cdd:cd17535    71 PDLKVIVLTAHDDPEYVLRALKAGAAGYLLK 101
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 11-118 3.90e-05

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 40.16  E-value: 3.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIdpSWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNhsRYQEIP 90
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRKA--GYAVDWVRTGAEAEAALASGP----YDLVILDLGLPDGDGLDLLRRWRR--QGQSLP 72

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17624    73 VLILTARDGVDDRVAGLDAGADDYLVKP 100
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 59-118 5.51e-05

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 40.94  E-value: 5.51e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  59 PALLVLDYNIPELTGVEVVKELNnhsRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:PRK10529   46 PDLIILDLGLPDGDGIEFIRDLR---QWSAIPVIVLSARSEESDKIAALDAGADDYLSKP 102
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 59-118 5.58e-05

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 39.88  E-value: 5.58e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1031984628  59 PALLVLDYNIPELTGVEVVKELNnhSRYQEIPKIIWSTSS--SPVFKAMsmELGAADYITKP 118
Cdd:cd17555    45 PDLVLCDLRMPEMDGLEVLKQIT--KESPDTPVIVVSGAGvmSDAVEAL--RLGAWDYLTKP 102
orf27 CHL00148
Ycf27; Reviewed
 11-118 1.06e-04

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 40.47  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIdpSWQVVCIPNGRKFVsyldTIQDKDLPALLVLDYNIPELTGVEVVKELNNHSryqEIP 90
Cdd:CHL00148    9 ILVVDDEAYIRKILETRLSII--GYEVITASDGEEAL----KLFRKEQPDLVILDVMMPKLDGYGVCQEIRKES---DVP 79

                          90       100
                  ....*....|....*....|....*....
gi 1031984628  91 kIIWSTSSSPVF-KAMSMELGAADYITKP 118
Cdd:CHL00148   80 -IIMLTALGDVSdRITGLELGADDYVVKP 107
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 61-125 1.12e-04

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 40.18  E-value: 1.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1031984628  61 LLVLDYNIPELTGVEVVKelnNHSRYQEIPKIIWSTSS-SPVFKAMSMELGAADYITKPNDVASFL 125
Cdd:PRK13856   48 VVVVDLNLGREDGLEIVR---SLATKSDVPIIIISGDRlEEADKVVALELGATDFIAKPFGTREFL 110
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 10-118 1.45e-04

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 40.05  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  10 LILLAEDDSDDQELLesafgeID--------PSWqvvcIPNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELN 81
Cdd:PRK10710   12 RILIVEDEPKLGQLL------IDylqaasyaTTL----LSHGDEVLPYVR----QTPPDLILLDLMLPGTDGLTLCREIR 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1031984628  82 nhsRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:PRK10710   78 ---RFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKP 111
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 11-121 1.48e-04

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 38.79  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRkfvSYLDTIQdKDLPALLVLDYNIPELTGVEVVKELnnHSRYQEIP 90
Cdd:cd19919     3 VWIVDDDSSIRWVLERALAGAG--LTVTSFENAQ---EALAALA-SSQPDVLISDIRMPGMDGLALLAQI--KQRHPDLP 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1031984628  91 KIIWsTSSSPVFKAMS-MELGAADYITKPNDV 121
Cdd:cd19919    75 VIIM-TAHSDLDSAVSaYQGGAFEYLPKPFDI 105
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 19-118 1.75e-04

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 39.31  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  19 DDQE--------LLESAfgeidpSWQVVCIPNGRKFVSYLDTiqdkDLPALLVLDYNIPELTGVEVVKELNNHSRyqEIP 90
Cdd:COG4566     6 DDDEavrdslafLLESA------GLRVETFASAEAFLAALDP----DRPGCLLLDVRMPGMSGLELQEELAARGS--PLP 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1031984628  91 kIIWSTSSSPVfkAMS---MELGAADYITKP 118
Cdd:COG4566    74 -VIFLTGHGDV--PMAvraMKAGAVDFLEKP 101
PRK10766 PRK10766
two-component system response regulator TorR;
61-132 1.79e-04

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 39.64  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1031984628  61 LLVLDYNIPELTGVEVVKELNNHSryqEIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYML 132
Cdd:PRK10766   49 LILLDINLPGEDGLMLTRELRSRS---TVGIILVTGRTDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLL 117
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 58-118 1.94e-04

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 38.19  E-value: 1.94e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1031984628  58 LPALLVLDYNIPELTGVEVVKELNNHSryqEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19936    42 PPDLAILDIKMPRMDGMELLQRLRQKS---TLPVIFLTSKDDEIDEVFGLRMGADDYITKP 99
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 59-118 2.08e-04

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 38.29  E-value: 2.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1031984628  59 PALLVLDYNIPELTGVEVVKELnnhSRYQEIPKIIWSTS-SSPVFKAMsmELGAADYITKP 118
Cdd:cd17532    45 PDVVFLDIQMPGLDGLELAKKL---SKLAKPPLIVFVTAyDEYAVEAF--ELNAVDYLLKP 100
ompR PRK09468
osmolarity response regulator; Provisional
 5-118 2.69e-04

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 39.19  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628   5 GHLNRLILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKfvsyLDTIQDKDLPALLVLDYNIPELTGVEVVKELNNHS 84
Cdd:PRK09468    2 MQENYKILVVDDDMRLRALLERYLTE--QGFQVRSAANAEQ----MDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQN 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1031984628  85 ryQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:PRK09468   76 --NPTPIIMLTAKGEEVDRIVGLEIGADDYLPKP 107
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 61-118 3.18e-04

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 37.42  E-value: 3.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1031984628  61 LLVLDYNIPELTGVEVVKELNNHSRyqEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19935    45 LIILDVMLPGLDGLEVLRRLRAAGK--QTPVLMLTARDSVEDRVKGLDLGADDYLVKP 100
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 55-120 3.66e-04

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 37.56  E-value: 3.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1031984628  55 DKDLPALLVLDYNIPELTGVEVVKELNNhsryQEIP-KIIWSTSSSPVFKAM-SMELGAADYITKPND 120
Cdd:cd17572    39 SDQPPDVVLLDLKLPDMSGMEILKWIQE----RSLPtSVIVITAHGSVDIAVeAMRLGAYDFLEKPFD 102
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 61-118 4.39e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 37.70  E-value: 4.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1031984628  61 LLVLDYNIPELTGVEVVKELNNHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19923    48 FVITDWNMPNMDGLELLKTIRADGALSHLPVLMVTAEAKKENVIAAAQAGVNNYIVKP 105
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 11-118 8.00e-04

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 36.88  E-value: 8.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGeiDPSWQVVCIPNGRKFVSYLDTiqdkDLPALLVLDYNIPELTGVEVVKELNNHSRyqEIP 90
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLS--DAGYVVDVAEDGEEALFQGEE----EPYDLVVLDLGLPGMDGLSVLRRWRSEGR--ATP 72

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd19934    73 VLILTARDSWQDKVEGLDAGADDYLTKP 100
pleD PRK09581
response regulator PleD; Reviewed
 53-124 8.98e-04

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 37.96  E-value: 8.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1031984628  53 IQDKDLPALLVLDYNIPELTGVEVVKELNNHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP-NDVASF 124
Cdd:PRK09581   41 ICEREQPDIILLDVMMPGMDGFEVCRRLKSDPATTHIPVVMVTALDDPEDRVRGLEAGADDFLTKPiNDVALF 113
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 11-118 1.00e-03

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 36.43  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEiDPSWQVVCI-PNGrkfVSYLDTIQDKDlPALLVLDYNIPELTGVEVVKELNNhSRYQEI 89
Cdd:cd17561     4 VLIADDNREFVQLLEEYLNS-QPDMEVVGVaHNG---QEALELIEEKE-PDVLLLDIIMPHLDGIGVLEKLRR-MRLEKR 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1031984628  90 PKIIWSTS---SSPVFKAmsMELGAADYITKP 118
Cdd:cd17561    78 PKIIMLTAfgqEDITQRA--VELGASYYILKP 107
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 61-132 1.09e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 37.60  E-value: 1.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1031984628  61 LLVLDYNIPELTGVEVVKELNNHSryQEIPKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYML 132
Cdd:PRK09836   47 LIILDIMLPDVNGWDIVRMLRSAN--KGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLL 116
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 11-118 1.15e-03

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 36.29  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLE---SAFGeidpsWQVVCIPNGRKFVSYLDTIQdkdlPALLVLDYNIPELTGVEVVKELNNHSRYQ 87
Cdd:cd17546     1 VLVVDDNPVNRKVLKkllEKLG-----YEVDVAENGQEALELLKEEP----FDLVLMDLQMPVMDGLEATRRIRELEGGG 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1031984628  88 EIPKII-WSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17546    72 RRTPIIaLTANALEEDREKCLEAGMDDYLSKP 103
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 11-118 1.45e-03

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 36.18  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKFVsyldTIQDKDLPALLVLDYNIPELTGVEVVKELNNHSryQEIP 90
Cdd:cd17615     2 VLVVDDEPNITELLSMALRY--EGWDVETAADGAEAL----AAAREFRPDAVVLDIMLPDMDGLEVLRRLRADG--PDVP 73

                          90       100
                  ....*....|....*....|....*...
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17615    74 VLFLTAKDSVEDRIAGLTAGGDDYVTKP 101
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 61-125 1.54e-03

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 36.04  E-value: 1.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1031984628  61 LLVLDYNIPELTGVEVVKELnnhsRYQEI--PKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFL 125
Cdd:cd17625    44 LIILDIMLPGMDGLEVLKSL----REEGIetPVLLLTALDAVEDRVKGLDLGADDYLPKPFSLAELL 106
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 11-118 1.55e-03

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 36.07  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpswQVVCIPNGRKFVSYLDTIQDKDlPALLVLDYNIPELTGVEVVKELnnHSRYQEIP 90
Cdd:cd19925     3 VLIVEDDPMVAEIHRAYVEQVP---GFTVIGTAGTGEEALKLLKERQ-PDLILLDIYLPDGNGLDLLREL--RAAGHDVD 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1031984628  91 KIIWSTSS--SPVFKAMSmeLGAADYITKP 118
Cdd:cd19925    77 VIVVTAANdvETVREALR--LGVVDYLIKP 104
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 59-118 2.07e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 35.52  E-value: 2.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  59 PALLVLDYNIPELTGVEVVKELNNHSryqEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17626    45 PDLVLLDLMLPGIDGIEVCRQIRAES---GVPIVMLTAKSDTVDVVLGLESGADDYVAKP 101
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 10-125 2.61e-03

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 35.50  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  10 LILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKFVSYLDtiqdKDLPALLVLDYNIPELTGVEVVKELNNHSryqEI 89
Cdd:cd17594     1 HVLVVDDDAAMRHLLILYLRE--RGFDVTAAADGAEEARLML----HRRVDLVLLDLRLGQESGLDLLRTIRARS---DV 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1031984628  90 PKIIWSTSS-SPVFKAMSMELGAADYITKPNDVASFL 125
Cdd:cd17594    72 PIIIISGDRrDEIDRVVGLELGADDYLAKPFGLRELL 108
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
59-125 2.79e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 36.03  E-value: 2.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1031984628  59 PALLVLDYNIPELTGVEVVKELNNHsRYQEIpKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFL 125
Cdd:PRK09958   46 PDIVIIDVDIPGVNGIQVLETLRKR-QYSGI-IIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNII 110
PRK11517 PRK11517
DNA-binding response regulator HprR;
11-125 3.82e-03

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 35.64  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEidPSWQVVCIPNGRKFVsYLDTiqdKDLPALLVLDYNIPELTGVEVVKELNNHsryQEIP 90
Cdd:PRK11517    3 ILLIEDNQRTQEWVTQGLSE--AGYVIDAVSDGRDGL-YLAL---KDDYALIILDIMLPGMDGWQILQTLRTA---KQTP 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITKPNDVASFL 125
Cdd:PRK11517   74 VICLTARDSVDDRVRGLDSGANDYLVKPFSFSELL 108
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 34-118 4.10e-03

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 34.91  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  34 SWQVVCIPNGRKFVSYLDtiQDKDLPALLVLDYNIPELTGVEVVKELNNHSryqEIPKIIWSTSSSPVFKAMSMELGAAD 113
Cdd:cd17584    22 GYQVTTCTDAEEALSMLR--ENKDEFDLVITDVHMPDMDGFEFLELIRLEM---DLPVIMMSADGSTSTVMKGLAHGACD 96


                  ....*
gi 1031984628 114 YITKP 118
Cdd:cd17584    97 YLLKP 101
PRK11173 PRK11173
two-component response regulator; Provisional
 61-118 4.48e-03

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 35.76  E-value: 4.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1031984628  61 LLVLDYNIPELTGVEVVKELNNHSryqEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:PRK11173   50 LVIMDINLPGKNGLLLARELREQA---NVALMFLTGRDNEVDKILGLEIGADDYITKP 104
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 11-117 5.54e-03

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 35.38  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  11 ILLAEDDSDDQELLESAFGEIDpsWQVVCIPNGRKfvsYLDTIQDKDlPALLVLDYNIPELTGVEVVKELnnHSRYQEiP 90
Cdd:PRK10701    4 IVFVEDDAEVGSLIAAYLAKHD--IDVTVEPRGDR---AEATILREQ-PDLVLLDIMLPGKDGMTICRDL--RPKWQG-P 74

                          90       100
                  ....*....|....*....|....*..
gi 1031984628  91 KIIWSTSSSPVFKAMSMELGAADYITK 117
Cdd:PRK10701   75 IVLLTSLDSDMNHILALEMGACDYILK 101
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 61-118 5.66e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 34.43  E-value: 5.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1031984628  61 LLVLDYNIPELTGVEVVKELnnHSRYQEIPKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17593    48 VLFLDLTMPVMDGYEVLEAL--PVEQLETKVIVVSGDVQPEAKERVLELGALAFLKKP 103
fixJ PRK09390
response regulator FixJ; Provisional
 47-118 7.07e-03

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 34.98  E-value: 7.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1031984628  47 VSYLDTIQDKdLPALLVLDYNIPELTGVEVVKELNNHSryQEIPKIIwSTSSSPVFKAM-SMELGAADYITKP 118
Cdd:PRK09390   37 QAFLDALPGL-RFGCVVTDVRMPGIDGIELLRRLKARG--SPLPVIV-MTGHGDVPLAVeAMKLGAVDFIEKP 105
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 10-133 7.72e-03

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 35.23  E-value: 7.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  10 LILLAEDDSDDQELLESAFGeiDPSWQVVCIPNGRKFVSYLDTiqdkDLPALLVLDYNIPELTGVEVVKELNNhsRYQEI 89
Cdd:PRK10923    5 IVWVVDDDSSIRWVLERALA--GAGLTCTTFENGNEVLEALAS----KTPDVLLSDIRMPGMDGLALLKQIKQ--RHPML 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1031984628  90 PKIIWSTSSSPVFKAMSMELGAADYITKPNDVASFLTIAKYMLS 133
Cdd:PRK10923   77 PVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAIS 120
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 61-118 8.34e-03

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 33.92  E-value: 8.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031984628  61 LLVLDYNIPELTGVEVVKELnnhsRYQEI--PKIIWSTSSSPVFKAMSMELGAADYITKP 118
Cdd:cd17616    45 IILLDLNLPDMSGYEVLRTL----RLAKVktPILILSGLADIEDKVKGLGFGADDYMTKP 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH