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Conserved domains on  [gi|943491920|dbj|BAT24354|]
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gluconate-6-phosphate dehydrogenase [Klebsiella sp. 1205]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11417508)

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 35-499 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 954.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  35 SKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENP-GKKLVPHYTVKEFVESLETPRRILLMVKAGAGT 113
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGkGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 114 DSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIA 193
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 194 ARAeDGEPCVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFS 273
Cdd:COG0362  161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 274 KKDEE-GKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPK-AQSAGDKVEFV 351
Cdd:COG0362  240 KKDPEtGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEaAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 352 EKVRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIAD 431
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943491920 432 EYQQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEW 499
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 35-499 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 954.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  35 SKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENP-GKKLVPHYTVKEFVESLETPRRILLMVKAGAGT 113
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGkGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 114 DSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIA 193
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 194 ARAeDGEPCVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFS 273
Cdd:COG0362  161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 274 KKDEE-GKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPK-AQSAGDKVEFV 351
Cdd:COG0362  240 KKDPEtGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEaAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 352 EKVRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIAD 431
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943491920 432 EYQQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEW 499
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
47-501 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 941.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  47 MGRNLALNIESRGYTVSVFNRSREKTEEVIAE-NPGKKLVPHYTVKEFVESLETPRRILLMVKAGAGTDSAIDSLKPYLD 125
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 126 KGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAARAEDGEPCVAY 205
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 206 IGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFSKKDEE-GKYLVD 284
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEEtGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 285 VILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPKAQSAGDKVEFVEKVRRALYLGKIV 364
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 365 SYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIADEYQQALRDVVAYA 444
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 943491920 445 VQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEWME 501
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSE 457
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 38-501 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 837.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920   38 QIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAE-NPGKKLVPHYTVKEFVESLETPRRILLMVKAGAGTDSA 116
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEeAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  117 IDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAARA 196
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  197 eDGEPCVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFSKKD 276
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  277 EEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPKAQSAG-DKVEFVEKVR 355
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGvDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  356 RALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIADEYQQ 435
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943491920  436 ALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEG--VFHTEWME 501
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTG 467
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 212-499 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 568.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  212 GHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFSKKDEE-GKYLVDVILDEA 290
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEdGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  291 ANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPK-AQSAGDKVEFVEKVRRALYLGKIVSYAQG 369
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPpALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  370 FSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIADEYQQALRDVVAYAVQNGI 449
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 943491920  450 PVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEW 499
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 35-499 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 954.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  35 SKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENP-GKKLVPHYTVKEFVESLETPRRILLMVKAGAGT 113
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGkGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 114 DSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIA 193
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 194 ARAeDGEPCVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFS 273
Cdd:COG0362  161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 274 KKDEE-GKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPK-AQSAGDKVEFV 351
Cdd:COG0362  240 KKDPEtGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEaAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 352 EKVRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIAD 431
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943491920 432 EYQQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEW 499
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
47-501 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 941.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  47 MGRNLALNIESRGYTVSVFNRSREKTEEVIAE-NPGKKLVPHYTVKEFVESLETPRRILLMVKAGAGTDSAIDSLKPYLD 125
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 126 KGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAARAEDGEPCVAY 205
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 206 IGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFSKKDEE-GKYLVD 284
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEEtGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 285 VILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPKAQSAGDKVEFVEKVRRALYLGKIV 364
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 365 SYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIADEYQQALRDVVAYA 444
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 943491920 445 VQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEWME 501
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSE 457
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 38-501 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 837.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920   38 QIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAE-NPGKKLVPHYTVKEFVESLETPRRILLMVKAGAGTDSA 116
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEeAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  117 IDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAARA 196
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  197 eDGEPCVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFSKKD 276
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  277 EEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPKAQSAG-DKVEFVEKVR 355
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGvDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  356 RALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIADEYQQ 435
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943491920  436 ALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEG--VFHTEWME 501
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTG 467
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 34-501 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 634.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  34 MSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVI--AENPGK-KLVPHYTVKEFVESLETPRRILLMVKAG 110
Cdd:PLN02350   4 AALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVerAKKEGNlPLYGFKDPEDFVLSIQKPRSVIILVKAG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 111 AGTDSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILE 190
Cdd:PLN02350  84 APVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 191 QIAARAEDGePCVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKD 270
Cdd:PLN02350 164 KVAAQVDDG-PCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITAD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 271 IFSKKDEEGK-YLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGP------KAQS 343
Cdd:PLN02350 243 IFSVKDDKGDgYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAgledilSADS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 344 AGDKVEFVEKVRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLA 423
Cdd:PLN02350 323 GVDKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVD 402

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943491920 424 PYFKQIADEYQQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEWME 501
Cdd:PLN02350 403 PEFAKEMVERQAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSFHTEWTK 480
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 39-499 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 629.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  39 IGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVI--AENPGKKLVPHYTVKEFVESLETPRRILLMVKAGAGTDSA 116
Cdd:PTZ00142   4 IGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVkkAKEGNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAVDET 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 117 IDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAARA 196
Cdd:PTZ00142  84 IDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCSAKV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 197 EDgEPCVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFSKKD 276
Cdd:PTZ00142 164 GD-SPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILAKKD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 277 EEGK-YLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPKA---QSAGDKVEFVE 352
Cdd:PTZ00142 243 DLGEeHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNPankTETEDKKYFID 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 353 KVRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIADE 432
Cdd:PTZ00142 323 DLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDELKN 402

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 943491920 433 YQQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEW 499
Cdd:PTZ00142 403 KQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAFHTNW 469
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 212-499 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 568.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  212 GHYVKMVHNGIEYGDMQLIAEAYSLLKGGLALSNEELATTFTEWNEGELSSYLIDITKDIFSKKDEE-GKYLVDVILDEA 290
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEdGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  291 ANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLTGPK-AQSAGDKVEFVEKVRRALYLGKIVSYAQG 369
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPpALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  370 FSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEQNAGIANLLLAPYFKQIADEYQQALRDVVAYAVQNGI 449
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 943491920  450 PVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEW 499
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
38-336 1.18e-90

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 278.94  E-value: 1.18e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  38 QIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENpgkkLVPHYTVKEFVESLETPRRILLMVKAGAGTDSAI 117
Cdd:PRK09599   2 QLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEG----ATGADSLEELVAKLPAPRVVWLMVPAGEITDATI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 118 DSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAARAE 197
Cdd:PRK09599  78 DELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 198 DGepcVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLK-GGLALSNEELATTfteWNEGE-LSSYLIDITKDIFsKK 275
Cdd:PRK09599 158 DG---YLHAGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEaSRFDLDLAAVAEV---WRRGSvIRSWLLDLTADAL-AE 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 943491920 276 DEEgkylVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYiSSLKDQRVAAsKVL 336
Cdd:PRK09599 231 DPK----LDEISGYVEDSGEGRWTVEEAIDLAVPAPVIAAALFMRF-RSRQEDSFAD-KVV 285
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
38-336 6.13e-88

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 271.96  E-value: 6.13e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  38 QIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENpgkkLVPHYTVKEFVESLETPRRILLMVKAGAGTDSAI 117
Cdd:COG1023    2 QIGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAALAAEG----ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 118 DSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAARAE 197
Cdd:COG1023   78 EELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 198 DGepcVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGG-LALSNEELATTfteWNEGE-LSSYLIDITKDIFSkK 275
Cdd:COG1023  158 NG---YLHCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASeFDLDLAEVAEV---WRRGSvIRSWLLDLTADALA-E 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 943491920 276 DEEgkylvdviLDE----AANKGTGKWTSQSSLDLGEPLSLITESVFARYiSSLKDQRVAAsKVL 336
Cdd:COG1023  231 DPK--------LEGisgyVEDSGEGRWTVEEAIELGVPAPVITAALFARF-RSRQEDSFAD-KVL 285
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 38-207 4.72e-66

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 210.02  E-value: 4.72e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920   38 QIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENpgkkLVPHYTVKEFVESLetpRRILLMVKAGAGTDSAI 117
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAG----AIAAASPAEFVAGL---DVVITMVPAGAAVDAVI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  118 DS--LKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAPILEQIAA 194
Cdd:pfam03446  74 FGegLLPGLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMGA 153

                         170
                  ....*....|...
gi 943491920  195 raedgepCVAYIG 207
Cdd:pfam03446 154 -------CVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 38-349 1.52e-56

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 190.44  E-value: 1.52e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920   38 QIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEvIAENPGKKLVphyTVKEFVESLETPRRILLMVKAGAgTDSAI 117
Cdd:TIGR00872   2 QLGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVKA-MKEDRTTGVA---NLRELSQRLSAPRVVWVMVPHGI-VDAVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  118 DSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAARae 197
Cdd:TIGR00872  77 EELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPE-- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  198 dgEPCVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGG-LALSNEELATTfteWNEGE-LSSYLIDITKDIFSKK 275
Cdd:TIGR00872 155 --EQGYLYCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSqFDFDIPEVARV---WRRGSvIRSWLLDLTAIAFRES 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 943491920  276 DEegkylVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDqrVAASKVLTGPKAQSAGDKVE 349
Cdd:TIGR00872 230 PD-----LAEFSGRVSDSGEGRWTVIAAIDLGVPAPVIATSLQSRFASRDLD--DFANKVLAALRKEFGGHAEK 296
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 36-243 1.31e-27

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 111.75  E-value: 1.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  36 KQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAEnpGKKLVPhyTVKEFVESLETprrILLMVKAGA---- 111
Cdd:COG2084    1 MMKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAA--GARVAA--SPAEAAAAADV---VITMLPDDAavee 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 112 ---GTDSAIDSLKPyldkGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAP 187
Cdd:COG2084   74 vllGEDGLLAALRP----GAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARP 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 943491920 188 ILEQIAARaedgepcVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLL-KGGLAL 243
Cdd:COG2084  150 VLEAMGKR-------IVHVGDAGAGQAAKLANNLLLAGTMAALAEALALAeKAGLDP 199
garR PRK11559
tartronate semialdehyde reductase; Provisional
 37-244 6.23e-16

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 78.17  E-value: 6.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  37 QQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPhytvKEFVESLETprrILLM------VKAG 110
Cdd:PRK11559   3 MKVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAETASTA----KAVAEQCDV---IITMlpnsphVKEV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 111 A-GTDSAIDSLKPyldkGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAPI 188
Cdd:PRK11559  76 AlGENGIIEGAKP----GTVVIDMSSIAPLASREIAAALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDL 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 189 LEQIAARaedgepcVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSL--------------LKGGLALS 244
Cdd:PRK11559 152 MKAMAGS-------VVHTGDIGAGNVTKLANQVIVALNIAAMSEALVLatkagvnpdlvyqaIRGGLAGS 214
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
38-233 1.56e-06

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 50.02  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920  38 QIGVVGMAVMGRNLALNIESRGYTVSVfnrsreKTEEVIAEnpgkKLVPHYTVkefveSLETPRR-------ILLMVKAG 110
Cdd:PRK15059   2 KLGFIGLGIMGTPMAINLARAGHQLHV------TTIGPVAD----ELLSLGAV-----SVETARQvteasdiIFIMVPDT 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920 111 AGTDSAI----DSLKPYLdKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELV 185
Cdd:PRK15059  67 PQVEEVLfgenGCTKASL-KGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERV 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 943491920 186 APILEQIAARaedgepcVAYIGADGAGHYVKMVHNGIEYGDMQLIAEA 233
Cdd:PRK15059 146 KPLFELLGKN-------ITLVGGNGDGQTCKVANQIIVALNIEAVSEA 186
ApbA pfam02558
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ...
 39-131 2.54e-04

Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.


Pssm-ID: 426831 [Multi-domain]  Cd Length: 147  Bit Score: 41.45  E-value: 2.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491920   39 IGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEE-----VIAENPGKKLVPHYTVKEFVESLETPRRILLMVKAgAGT 113
Cdd:pfam02558   1 IAILGAGAIGSLLGARLAKAGHDVTLILRGAELAAIkknglRLTSPGGERIVPPPAVTSASESLGPIDLVIVTVKA-YQT 79

                          90
                  ....*....|....*...
gi 943491920  114 DSAIDSLKPYLDKGDIII 131
Cdd:pfam02558  80 EEALEDIAPLLGPNTVVL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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