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Conserved domains on  [gi|943490760|dbj|BAT23251|]
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putative pyruvyl transferase [Klebsiella sp. 1015]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 73-292 7.58e-04

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member pfam04230:

Pssm-ID: 471961  Cd Length: 233  Bit Score: 40.31  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943490760   73 NHAHKIHDKLYTAIPTKKTITLMDYVKLDALIIPG----CVLTVPFFKIFGAELEALKNKGTELIFLGAS-GNYYTDYEV 147
Cdd:pfam04230  32 DETKKRLSDKRSKKLKLLKKLLKLLDKADDVIIVGgglgNLGDLYKLLIYLRLAFVAKKLGKPVILLGQGiGPFLNEALR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943490760  148 SFVKEYIKKLEPkgIIFRDHVAYENYKD--IVEVSHNGIDNAFFVnkvtvpkniasedyvvlnfdhpknDHMIQELSGKF 225
Cdd:pfam04230 112 KLLKKILSKADL--ISVRDELSYELLEKlgIKENVELVPDPAFLL------------------------DKLPPKEIKKK 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 943490760  226 NKVVVTNNKPYPLSYVKSLLAQDIFVSDTPLDYLILLANAKEVHSDRVHSCIPTLSFGGKCRIYSHS 292
Cdd:pfam04230 166 PKKDYISIAKSSKKDLEDLNEKLALLYDLPEELLSLISQADFVITTRLHGLILALLFGVPFIVIAYD 232
 
Name Accession Description Interval E-value
PS_pyruv_trans pfam04230
Polysaccharide pyruvyl transferase; Pyruvyl-transferases involved in peptidoglycan-associated ...
 73-292 7.58e-04

Polysaccharide pyruvyl transferase; Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.


Pssm-ID: 427804  Cd Length: 233  Bit Score: 40.31  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943490760   73 NHAHKIHDKLYTAIPTKKTITLMDYVKLDALIIPG----CVLTVPFFKIFGAELEALKNKGTELIFLGAS-GNYYTDYEV 147
Cdd:pfam04230  32 DETKKRLSDKRSKKLKLLKKLLKLLDKADDVIIVGgglgNLGDLYKLLIYLRLAFVAKKLGKPVILLGQGiGPFLNEALR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943490760  148 SFVKEYIKKLEPkgIIFRDHVAYENYKD--IVEVSHNGIDNAFFVnkvtvpkniasedyvvlnfdhpknDHMIQELSGKF 225
Cdd:pfam04230 112 KLLKKILSKADL--ISVRDELSYELLEKlgIKENVELVPDPAFLL------------------------DKLPPKEIKKK 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 943490760  226 NKVVVTNNKPYPLSYVKSLLAQDIFVSDTPLDYLILLANAKEVHSDRVHSCIPTLSFGGKCRIYSHS 292
Cdd:pfam04230 166 PKKDYISIAKSSKKDLEDLNEKLALLYDLPEELLSLISQADFVITTRLHGLILALLFGVPFIVIAYD 232
 
Name Accession Description Interval E-value
PS_pyruv_trans pfam04230
Polysaccharide pyruvyl transferase; Pyruvyl-transferases involved in peptidoglycan-associated ...
 73-292 7.58e-04

Polysaccharide pyruvyl transferase; Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.


Pssm-ID: 427804  Cd Length: 233  Bit Score: 40.31  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943490760   73 NHAHKIHDKLYTAIPTKKTITLMDYVKLDALIIPG----CVLTVPFFKIFGAELEALKNKGTELIFLGAS-GNYYTDYEV 147
Cdd:pfam04230  32 DETKKRLSDKRSKKLKLLKKLLKLLDKADDVIIVGgglgNLGDLYKLLIYLRLAFVAKKLGKPVILLGQGiGPFLNEALR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943490760  148 SFVKEYIKKLEPkgIIFRDHVAYENYKD--IVEVSHNGIDNAFFVnkvtvpkniasedyvvlnfdhpknDHMIQELSGKF 225
Cdd:pfam04230 112 KLLKKILSKADL--ISVRDELSYELLEKlgIKENVELVPDPAFLL------------------------DKLPPKEIKKK 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 943490760  226 NKVVVTNNKPYPLSYVKSLLAQDIFVSDTPLDYLILLANAKEVHSDRVHSCIPTLSFGGKCRIYSHS 292
Cdd:pfam04230 166 PKKDYISIAKSSKKDLEDLNEKLALLYDLPEELLSLISQADFVITTRLHGLILALLFGVPFIVIAYD 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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