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Conserved domains on  [gi|449018383|dbj|BAM81785|]
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unknown DNA-binding protein [Cyanidioschyzon merolae strain 10D]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13031747)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein

Gene Ontology:  GO:0005515
PubMed:  27521773|17120193

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-229 5.69e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 81.45  E-value: 5.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGnRCIWAHRVVLAARSPVFEKILEK--RTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQ 227
Cdd:cd18186    2 CDVTLVVGG-REFPAHRAVLAARSPYFRAMFSSgmKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 449018383 228 RF 229
Cdd:cd18186   81 KL 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-116 2.97e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 70.75  E-value: 2.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  33 PLHIWCRTpGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGERVLYAALT---PEI 109
Cdd:COG0666  123 PLHLAAYN-GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEnghLEI 201


                 ....*..
gi 449018383 110 KRLLLQY 116
Cdd:COG0666  202 VKLLLEA 208
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 278-364 7.24e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18296:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 121  Bit Score: 39.97  E-value: 7.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 278 EQDLEHLLSRTDNMP-FVDVYVQVtcpgptyEECSLLVYPAhwLFLRRAEYFRAL-RDFYRDR---SSACAIVRIPsNIS 352
Cdd:cd18296    1 RVDLDELPFPPEQELsFPDVCFQV-------EGHRFPCHKA--FFCGRSDYFKALlRDHFAESeenNGSIPVVTLH-DVS 70

                         90
                 ....*....|..
gi 449018383 353 PFAFECVLHHMY 364
Cdd:cd18296   71 PEVFAIVLYYIY 82
 
Name Accession Description Interval E-value
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-229 5.69e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 81.45  E-value: 5.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGnRCIWAHRVVLAARSPVFEKILEK--RTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQ 227
Cdd:cd18186    2 CDVTLVVGG-REFPAHRAVLAARSPYFRAMFSSgmKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 449018383 228 RF 229
Cdd:cd18186   81 KL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 151-242 1.30e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.95  E-value: 1.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383   151 DVGFRLEGNRcIWAHRVVLAARSPVFEKILEKRTSPGK--VLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQR 228
Cdd:smart00225   1 DVTLVVGGKK-FHAHKAVLAAHSPYFKALFSSDFKESDksEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....
gi 449018383   229 FHLDELAQEVDRQR 242
Cdd:smart00225  80 LQIPGLVELCEEFL 93
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-116 2.97e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 70.75  E-value: 2.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  33 PLHIWCRTpGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGERVLYAALT---PEI 109
Cdd:COG0666  123 PLHLAAYN-GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEnghLEI 201


                 ....*..
gi 449018383 110 KRLLLQY 116
Cdd:COG0666  202 VKLLLEA 208
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 158-236 2.59e-12

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 63.43  E-value: 2.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  158 GNRCIWAHRVVLAARSPVFEKILE--KRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVsVRVRHAEEFMTIAQRFHLDELA 235
Cdd:pfam00651  18 GDKEFRAHKAVLAACSPYFKALFSgqESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSLV 96


                  .
gi 449018383  236 Q 236
Cdd:pfam00651  97 D 97
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-114 2.54e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 2.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  33 PLHIWCRTPGNLAK--VRALVERGADVNAVDEHDATPVYYCALTGN-APVLRFLLEAGAVLDPKTFVGERVLYAALT--- 106
Cdd:PHA03095  50 PLHLYLHYSSEKVKdiVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfn 129

                         90
                 ....*....|
gi 449018383 107 --PEIKRLLL 114
Cdd:PHA03095 130 inPKVIRLLL 139
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-84 5.44e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 5.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 449018383   33 PLHiWCRTPGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLL 84
Cdd:pfam13637   4 ALH-AAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 278-364 7.24e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 39.97  E-value: 7.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 278 EQDLEHLLSRTDNMP-FVDVYVQVtcpgptyEECSLLVYPAhwLFLRRAEYFRAL-RDFYRDR---SSACAIVRIPsNIS 352
Cdd:cd18296    1 RVDLDELPFPPEQELsFPDVCFQV-------EGHRFPCHKA--FFCGRSDYFKALlRDHFAESeenNGSIPVVTLH-DVS 70

                         90
                 ....*....|..
gi 449018383 353 PFAFECVLHHMY 364
Cdd:cd18296   71 PEVFAIVLYYIY 82
 
Name Accession Description Interval E-value
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-229 5.69e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 81.45  E-value: 5.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGnRCIWAHRVVLAARSPVFEKILEK--RTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQ 227
Cdd:cd18186    2 CDVTLVVGG-REFPAHRAVLAARSPYFRAMFSSgmKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 449018383 228 RF 229
Cdd:cd18186   81 KL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 151-242 1.30e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.95  E-value: 1.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383   151 DVGFRLEGNRcIWAHRVVLAARSPVFEKILEKRTSPGK--VLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQR 228
Cdd:smart00225   1 DVTLVVGGKK-FHAHKAVLAAHSPYFKALFSSDFKESDksEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....
gi 449018383   229 FHLDELAQEVDRQR 242
Cdd:smart00225  80 LQIPGLVELCEEFL 93
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 126-237 1.48e-13

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 67.27  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 126 DALTEHLRAVLEGNENvgghvdddADVGFRLEGnRCIWAHRVVLAARSPVFEKILEKRTSPGKVLRLKH--VSTDAFEAF 203
Cdd:cd18295    4 DYYDEFLRRLLEQGSY--------SDVTFNVHG-ESFPAHRCILSARSPYFAEMFETKWKDKREINLKHplVNPDAFRAL 74

                         90       100       110
                 ....*....|....*....|....*....|....
gi 449018383 204 LRYLYTSTVSVRVRHAEEFMTIAQRFHLDELAQE 237
Cdd:cd18295   75 LQYLYTGRLEIHVDDVEDCKRLAKQCRLEELIEE 108
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-116 2.97e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 70.75  E-value: 2.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  33 PLHIWCRTpGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGERVLYAALT---PEI 109
Cdd:COG0666  123 PLHLAAYN-GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEnghLEI 201


                 ....*..
gi 449018383 110 KRLLLQY 116
Cdd:COG0666  202 VKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-142 4.54e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 70.37  E-value: 4.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  33 PLHIWCRTpGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGERVLYAALT---PEI 109
Cdd:COG0666  156 PLHLAAAN-GNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAEngnLEI 234

                         90       100       110
                 ....*....|....*....|....*....|...
gi 449018383 110 KRLLLQYREQTLPSYTDALTEHLRAVLEGNENV 142
Cdd:COG0666  235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-240 1.15e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 64.99  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGnRCIWAHRVVLAARSPVFEKILE--KRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVS---VRVRHAEEFMT 224
Cdd:cd18297   13 SDVTFLVEG-RPFYAHKIVLVTASDRFKSMLSsgSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDALELLR 91

                         90
                 ....*....|....*.
gi 449018383 225 IAQRFHLDELAQEVDR 240
Cdd:cd18297   92 AASFFQLDGLKRHCEI 107
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 158-236 2.59e-12

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 63.43  E-value: 2.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  158 GNRCIWAHRVVLAARSPVFEKILE--KRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVsVRVRHAEEFMTIAQRFHLDELA 235
Cdd:pfam00651  18 GDKEFRAHKAVLAACSPYFKALFSgqESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSLV 96


                  .
gi 449018383  236 Q 236
Cdd:pfam00651  97 D 97
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-116 2.90e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.67  E-value: 2.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  30 DGLPLHIWCRTPGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGERVLYAALT--- 106
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAngn 165

                         90
                 ....*....|
gi 449018383 107 PEIKRLLLQY 116
Cdd:COG0666  166 LEIVKLLLEA 175
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 150-236 2.74e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 60.30  E-value: 2.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGNRCIWAHRVVLAARSPVFEKILEKRTspgKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRF 229
Cdd:cd18299   13 ADVVFILQGGVRIFAHRIVLAAASSVFADLFLMMT---VVTLDSDITPEAFRRVLEFLYTGVLDENEDDLKELKDAAELL 89


                 ....*..
gi 449018383 230 HLDELAQ 236
Cdd:cd18299   90 ELFDLVM 96
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 151-234 4.04e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 57.26  E-value: 4.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 151 DVGFRLEGNR-CIWAHRVVLAARSPVFEKIL---EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIA 226
Cdd:cd18294   16 DVKFLVGPERqEIFAHKCILAARCEVFRAMFltgPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAA 95


                 ....*...
gi 449018383 227 QRFHLDEL 234
Cdd:cd18294   96 VEYGLDEL 103
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 150-233 1.85e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 54.86  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGnRCIWAHRVVLAARSPVFEKIL-EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQR 228
Cdd:cd18315    2 VDVTLACEG-GSLKAHKLVLAAASPYFAALLkETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80


                 ....*
gi 449018383 229 FHLDE 233
Cdd:cd18315   81 LQIKG 85
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-234 4.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 54.55  E-value: 4.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 147 DDDADVGFRLEGNRcIWAHRVVLAARSPVFEKILEK--RTSPGKVLRLKHVSTDAFEAFLRYLYTSTVS---VRVRHAEE 221
Cdd:cd18287   20 EEYSDVTFVVEEKR-FPAHRVILAARSEYFRALLYGgmRESQQSEIELKDTNAEAFKALLKYIYTGRLTltdLKEDVLLD 98

                         90
                 ....*....|...
gi 449018383 222 FMTIAQRFHLDEL 234
Cdd:cd18287   99 VLGLAHQYGFEEL 111
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 150-235 4.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 51.19  E-value: 4.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLeGNRCIWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQ 227
Cdd:cd18314    7 SDVVLCV-GDRKFFAHRIVLCARSPVFRSMLtgSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLAS 85


                 ....*...
gi 449018383 228 RFHLDELA 235
Cdd:cd18314   86 KYQVPDLE 93
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 150-234 5.05e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 51.47  E-value: 5.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGnRCIWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVR-VRHAEEFMTIA 226
Cdd:cd18300   10 SDVTFIVED-GTIPAHKALLVARCDVMAAMFggNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILeDGDCVGLIVLA 88


                 ....*...
gi 449018383 227 QRFHLDEL 234
Cdd:cd18300   89 NRLCLPRL 96
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 150-213 5.13e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 52.31  E-value: 5.13e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 449018383 150 ADVGFRLEGNRCIWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLK--------HVSTDAFEAFLRYLYTSTVS 213
Cdd:cd18310   19 SDAEIIVEGGRPVPVHRCILAARSPFFRDIFasAKAEGANTKPKLElrelipggIVGYDAFMLVLSYLYSGRLR 92
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-236 1.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 50.15  E-value: 1.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGNRCIWAHRVVLAARSPVFEKIL--------EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEE 221
Cdd:cd18288   19 SDVQFQTDSGEVLYAHSFVLYARCPLLIQMVhsegfsveEEGGVTTRRVLLGDVSGEAARCFLQYLYTADTGLPPGLSPH 98

                         90
                 ....*....|....*
gi 449018383 222 FMTIAQRFHLDELAQ 236
Cdd:cd18288   99 VSELADRFGVSELVH 113
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-118 1.79e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.03  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  33 PLHIWCRTpGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGERVLYAALTPEIKRL 112
Cdd:COG0666  189 PLHLAAEN-GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267


                 ....*.
gi 449018383 113 LLQYRE 118
Cdd:COG0666  268 VKLLLL 273
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-214 2.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 49.59  E-value: 2.47e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKILekrTSPGKVLRLKHVST--------DAFEAFLRYLYTSTVSV 214
Cdd:cd18292   25 GGKVFHAHRLILAKSSDVFRVML---SNDWWSESKQSEIElvedpecaAVFEKFLRYLYTGQISV 86
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-114 2.54e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 2.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  33 PLHIWCRTPGNLAK--VRALVERGADVNAVDEHDATPVYYCALTGN-APVLRFLLEAGAVLDPKTFVGERVLYAALT--- 106
Cdd:PHA03095  50 PLHLYLHYSSEKVKdiVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfn 129

                         90
                 ....*....|
gi 449018383 107 --PEIKRLLL 114
Cdd:PHA03095 130 inPKVIRLLL 139
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 123-241 2.76e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 49.96  E-value: 2.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 123 SYTDALTEHLRAVLE---GNENVGGHVdddADVGFRLeGNRCIWAHRVVLAARSPVFEKILEKRTSPG---KVLRLKHVS 196
Cdd:cd18207    1 SYTYQVSQHSADMLHnlnQQRKSGGRF---CDVLLRV-GEESFPAHRAVLAACSEYFESVFSAQEGDGgtpRELEMHTIS 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 449018383 197 TDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLD---ELAQEVDRQ 241
Cdd:cd18207   77 SKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRsviDICQEVIKQ 124
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-236 2.83e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 49.71  E-value: 2.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKILEKRTSPG--KVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELA 235
Cdd:cd18256   28 GMELFSVHRLVLAASSPYFAALFAGGMSESskDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVV 107


                 .
gi 449018383 236 Q 236
Cdd:cd18256  108 E 108
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-234 5.68e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 49.21  E-value: 5.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGnRCIWAHRVVLAARSPVFEKILEKR-TSPGKVLRLKHVSTDAFEAFLRYLYT-STVSVRVRHAE--EFMTI 225
Cdd:cd18351   25 SDVTFLVEG-RPFYAHKVLLFTASPRFKALLSNKpSAENTCIEISYVKYHIFQLVMQYLYCgGTESLLIKNNEimELLSA 103


                 ....*....
gi 449018383 226 AQRFHLDEL 234
Cdd:cd18351  104 AKFFQLEAL 112
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-236 6.44e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 48.80  E-value: 6.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKILEKRTSPGKVL--RLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELA 235
Cdd:cd18306   26 GGHEIPAHRAVLACASPYLFELFSSDSDGESILtvKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVK 105


                 .
gi 449018383 236 Q 236
Cdd:cd18306  106 K 106
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-212 1.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 47.47  E-value: 1.04e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449018383 150 ADVGFRLEGNRCIWAHRVVLAARSPVFEKILE--KRTSPGKVLRLKHVSTDAFEAFLRYLYTSTV 212
Cdd:cd18313    2 ADVEIETDNNSHIPAHSNVLASASPVIAGMLKqpRRKSSKKVIKILGVPCDAVRVFIRFLYSSCY 66
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 147-211 2.85e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 46.13  E-value: 2.85e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 449018383 147 DDDADVGFRLEGNRcIWAHRVVLAARSPVFEKIL--EKRTSPGKV----LRLKHVSTDAFEAFLRYLYTST 211
Cdd:cd18301   16 DNIHDVVFQVGGKT-FPAHKFILASRSDYFRKLFlsSLLTSEDAVgcdvVHIEKVPPEIFEQLLQFIYTDT 85
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-241 3.23e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 46.47  E-value: 3.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 148 DDADVGFRLEGnRCIWAHRVVLAARSPVFEKILEKRTSpgKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHA---EEFMT 224
Cdd:cd18354   19 DTADLKFLVDG-KYIYVHKVLLKIRCEHFRSLLNENEE--EIIEMSQFSYPVYRAFLEYLYTDSISLSPEDAiglLDLAT 95

                         90
                 ....*....|....*..
gi 449018383 225 IAQRFHLDELAQEVDRQ 241
Cdd:cd18354   96 FYRENRLKKLCQQTIKQ 112
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 155-237 3.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 46.18  E-value: 3.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 155 RLEGNRC----------IWAHRVVLAARSPVFEKILEK-RTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFM 223
Cdd:cd18204   13 RLEGEFCdiaivvedvkFRAHRCVLAACSTYFKKLFKKlEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMM 92

                         90
                 ....*....|....*...
gi 449018383 224 TIAQ----RFhLDELAQE 237
Cdd:cd18204   93 SSGQilgiRF-LDKLCSQ 109
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-214 3.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 46.09  E-value: 3.74e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 449018383 148 DDADVGFRLEGNRcIWAHRVVLAARSPVFEKILEKRTSPGK--VLRLKHVSTDAFEAFLRYLYTSTVSV 214
Cdd:cd18298   11 RTSDLKFRVDGKY-IYVHKAILKIRCEYFRSMFQSHWNEDDknVIEIDQYSYPVYYAFLRYLYTDQVDL 78
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 151-234 3.79e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 46.32  E-value: 3.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 151 DVGFRLEGnRCIWAHRVVLAARSPVFEKILEKRTSP---GKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQ 227
Cdd:cd18293   17 DVLLQAEG-ESVPAHCCVLSACSPYLTERLSSEPPPagqKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAAR 95


                 ....*..
gi 449018383 228 RFHLDEL 234
Cdd:cd18293   96 RLQISEL 102
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-84 5.44e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 5.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 449018383   33 PLHiWCRTPGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLL 84
Cdd:pfam13637   4 ALH-AAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-234 8.97e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.38  E-value: 8.97e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 449018383 164 AHRVVLAARSPVFEKILEKRTSPGKVLR--LKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDEL 234
Cdd:cd18343   35 AHKSILAARSPVFNAMFEHEMEESKKNRveINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERL 107
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 151-239 9.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 45.56  E-value: 9.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 151 DVGFRLEGnRCIWAHRVVLAARSPVFE-----KILEKRTSPgkvLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTI 225
Cdd:cd18237   23 DVILIVEG-REIKAHRVVLAAASHFFHlmftsNMTESKSSE---VELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDA 98

                         90       100
                 ....*....|....*....|..
gi 449018383 226 AQRFHL--------DELAQEVD 239
Cdd:cd18237   99 ANQYQIepvkkmcvDFLKEQLD 120
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 150-220 1.38e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 44.26  E-value: 1.38e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 449018383 150 ADVGFRLEGNRcIWAHRVVLAARSP-VFEKILEKRTSPG--KVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAE 220
Cdd:cd18285   16 TDVTFYVGSTL-FKAHKAILLARVPeFFSHIIGKLSSLEdqEPINIENLEASEFKTFLRQVYTSDKNIKMLEEE 88
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-231 1.44e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 45.09  E-value: 1.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHL 231
Cdd:cd18269   35 GDKEFPCHRLVLAACSPYFRAMFlsDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQI 110
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-231 1.70e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 44.84  E-value: 1.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHL 231
Cdd:cd18341   35 GDKSLPCHRLILAACSPYFREYFlsEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQI 110
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-116 1.85e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 1.85e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 449018383  47 VRALVERGADVNAVDEHDATPVYYCALTGNAP---VLRFLLEAGAVLDPKTFVG----ERVLYAALTPEIKRLLLQY 116
Cdd:PHA03095  30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGftplHLYLYNATTLDVIKLLIKA 106
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-116 2.12e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.87  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  30 DGLPLHIWCRTPGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGERVLYAALT--- 106
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYngn 132

                         90
                 ....*....|
gi 449018383 107 PEIKRLLLQY 116
Cdd:COG0666  133 LEIVKLLLEA 142
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 128-211 2.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 43.86  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 128 LTEHLRAVLEGNENvgghvdddADVGFRLEGNRcIWAHRVVLAARSPVFEKILEKRTSPG--KVLRLKHVSTDAFEAFLR 205
Cdd:cd18280    1 LGQHFGALLESEEG--------ADVTFNVDGEK-FRAHKLVLAARSPVFRSMLFGPMREEneGEIVIEDVEPPVFKALLH 71


                 ....*.
gi 449018383 206 YLYTST 211
Cdd:cd18280   72 FIYKDE 77
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-234 2.97e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 43.68  E-value: 2.97e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKILEKRTSPGKVLRLK--HVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDEL 234
Cdd:cd18345   26 GGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEitDVDHEVMREMLRFIYTGKAPNLDKMADDLLAAADKYALERL 104
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-234 3.31e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 43.94  E-value: 3.31e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 449018383 164 AHRVVLAARSPVFEKILEKRTSPGKVLR--LKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDEL 234
Cdd:cd18342   36 AHKAILAARSPVFSAMFEHEMEESKKNRveINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERL 108
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-88 3.73e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 3.73e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 449018383  33 PLHIWCRTPGNLAKV-RALVERGADVNAVDEHDATPVYYCALTGNAPV--LRFLLEAGA 88
Cdd:PHA03095 120 PLHVYLSGFNINPKViRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGA 178
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 150-236 7.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 42.46  E-value: 7.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLEGNRcIWAHRVVLAARSPVFEKILEK--RTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQ 227
Cdd:cd18352   14 SDVTFLVEGRR-FYAHRIALLASSDAFRAMFDGgyREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAAD 92


                 ....*....
gi 449018383 228 RFHLDELAQ 236
Cdd:cd18352   93 QYLLEGLKR 101
Ank_2 pfam12796
Ankyrin repeats (3 copies);
42-116 1.32e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 1.32e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 449018383   42 GNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDpkTFVGERVLYAALT---PEIKRLLLQY 116
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARsghLEIVKLLLEK 83
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 151-226 1.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 42.04  E-value: 1.37e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 449018383 151 DVGFRLEGNRcIWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIA 226
Cdd:cd18242   23 DVTLRVEGKE-FPAHRIVLAACSDYFCAMFtsEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAA 99
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 161-229 1.55e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 40.78  E-value: 1.55e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 449018383 161 CIWAHRVVLAARSPVFEKILEKRTSPGKV----LRLKHVSTDAFEAFLRYLYTSTVSV---RVRHAEEFMTIAQRF 229
Cdd:cd18283   13 CFPVHRAILSARCPFFRDLLSSSPGYGAEipvdLPTAGIDVPMFSALLRYLYTGEFGSedsRSQNLDVLIQLSEEF 88
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-234 2.28e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 41.36  E-value: 2.28e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 449018383 164 AHRVVLAARSPVFEKILEKRTSPGKVLRLK--HVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDEL 234
Cdd:cd18279   32 AHKAILAARSPVFSAMFEHEMEESKKNRVEinDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERL 104
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-236 2.56e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 41.12  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELA 235
Cdd:cd18238   23 GEKSIHCHRLVLACVSPYFRAMFtsEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVA 102


                 .
gi 449018383 236 Q 236
Cdd:cd18238  103 K 103
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-214 2.68e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 41.03  E-value: 2.68e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 449018383 164 AHRVVLAARSPVFEKILEKRT---------------SPGKVLRLKHVSTDAFEAFLRYLYTSTVSV 214
Cdd:cd18195   32 AHRSVLAASSPYFRELLSSPLplgaaavaaapgatqSPERVLELPGVKAGVFSDVLNFIYSSRVAL 97
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-234 2.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 40.77  E-value: 2.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 150 ADVGFRLeGNRCIWAHRVVLAARSPVFEKILEKRTspgKVLRLKHVSTDAFEAFLRYLYTSTVSVRV--RHAEEFMTIAQ 227
Cdd:cd18303   19 SDITIKL-ADKSIPAHKFVLAARSEKWSNENLAST---NELDLSDISYEVVLALLRWLYTDELDLTLddEFLLELMKAAK 94


                 ....*..
gi 449018383 228 RFHLDEL 234
Cdd:cd18303   95 RFQLTDL 101
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-235 3.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 40.51  E-value: 3.96e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 449018383 164 AHRVVLAARSPVFEKILEKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELA 235
Cdd:cd18217   32 AHRNVLAAFSEYFGAQYKDTEDNIVFLDQSQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVV 103
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 165-231 4.03e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 40.97  E-value: 4.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 449018383 165 HRVVLAARSPVFEKILEKRTSPGKV--LRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHL 231
Cdd:cd18340   42 HRLVLAACSPYFRAMFLSDLEESKKreIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQI 110
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 147-208 4.20e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 40.32  E-value: 4.20e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 449018383 147 DDDADVGFRLEGnRCIWAHRVVLAARSPVFEKILEK--RTSPGKVLRLKHVSTDAFEAFLRYLY 208
Cdd:cd18286   15 GEDSDITIKVDG-KTFKAHRCILCARSSYFAAMLSGswAESNSSEITLTGVSHAAVSFVLLFIY 77
Ank_2 pfam12796
Ankyrin repeats (3 copies);
22-88 4.88e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 4.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 449018383   22 VDERTMTVDGL-PLHIWCRTpGNLAKVRALVERgADVNAVDEHDaTPVYYCALTGNAPVLRFLLEAGA 88
Cdd:pfam12796  21 ADANLQDKNGRtALHLAAKN-GHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGA 85
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 151-237 5.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 40.00  E-value: 5.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 151 DVGFRLEGnRCIWAHRVVLAARSPVFEKILEKRTSPG--KVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQR 228
Cdd:cd18240   19 DVVIRVNG-VEFPAHRNILCACSPYFRALFTNGWNETekKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPAADQ 97


                 ....*....
gi 449018383 229 FHLDELAQE 237
Cdd:cd18240   98 FNIMGIVKA 106
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-105 6.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.74  E-value: 6.52e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 449018383  50 LVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGERVLYAAL 105
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAV 219
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 278-364 7.24e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 39.97  E-value: 7.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 278 EQDLEHLLSRTDNMP-FVDVYVQVtcpgptyEECSLLVYPAhwLFLRRAEYFRAL-RDFYRDR---SSACAIVRIPsNIS 352
Cdd:cd18296    1 RVDLDELPFPPEQELsFPDVCFQV-------EGHRFPCHKA--FFCGRSDYFKALlRDHFAESeenNGSIPVVTLH-DVS 70

                         90
                 ....*....|..
gi 449018383 353 PFAFECVLHHMY 364
Cdd:cd18296   71 PEVFAIVLYYIY 82
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 314-371 7.26e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 7.26e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 314 VYPAHWLFLR-RAEYFRALrdFYRD-RSSACAIVRIPsNISPFAFECVLHHMYHSSLPRN 371
Cdd:cd18186   12 EFPAHRAVLAaRSPYFRAM--FSSGmKESSSSEIELD-DVSPEAFEALLDYIYTGELELS 68
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-116 1.05e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.96  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  33 PLHIWCRTPGNLAKVRA----LVERGADVNAVDEHDATPVYYCALT--GNAPVLRFLLEAGAVLDPKTFVGERVLYAAL- 105
Cdd:PHA03100  71 PLHYLSNIKYNLTDVKEivklLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLe 150

                         90
                 ....*....|....*
gi 449018383 106 ----TPEIKRLLLQY 116
Cdd:PHA03100 151 snkiDLKILKLLIDK 165
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 162-236 1.07e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 39.28  E-value: 1.07e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 449018383 162 IWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELAQ 236
Cdd:cd18338   33 IAAHRVVLAACSPYFHAMFtgEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK 109
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-236 1.13e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 39.28  E-value: 1.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449018383 164 AHRVVLAARSPVFEKILEK--RTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELAQ 236
Cdd:cd18248   39 AHKVVLASSSPYFKAMFTSglRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVK 113
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 33-88 1.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 1.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 449018383  33 PLHIWCRTPGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGA 88
Cdd:PHA02876 344 PLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 162-214 1.68e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 38.95  E-value: 1.68e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 449018383 162 IWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSV 214
Cdd:cd18235   33 IPAHRVVLASCSPYFHAMFtgDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQV 87
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-236 1.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 38.50  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELA 235
Cdd:cd18234    9 GDRRIPAHRLVLSAVSDYFAAMFtnDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVV 88


                 .
gi 449018383 236 Q 236
Cdd:cd18234   89 E 89
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 158-214 1.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 38.32  E-value: 1.84e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 449018383 158 GNRCIWAHRVVLAARSPVFEKIL-EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSV 214
Cdd:cd18209   26 GDQKFRAHKNVLAASSEYFQSLFtEKENESQSVFQLDFCEPDAFENVLNYIYSSSLFV 83
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-235 1.92e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 38.36  E-value: 1.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 449018383 164 AHRVVLAARSPVFEKILEKRTSPGKV-LRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELA 235
Cdd:cd18231   30 AHKGVLAAYSQFFHSLFTQNKQLQRVeLSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIA 102
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 42-88 2.60e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 2.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 449018383  42 GNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGA 88
Cdd:PTZ00322  93 GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA 139
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-234 2.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 38.30  E-value: 2.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 149 DADVGFRLEGNRCIWAHRVVLAARSPVFEKIL-----EKRTspGKVLRLKHVST-----DAFEAFLRYLYTSTVSVRVRH 218
Cdd:cd18241   25 DITLAFGGAGGREFRAHRSVLAAATEYFTPLLsgqfsESRS--GRVEMRKWSSEpgpdpDTVEAVIQYMYTGRIRVSTGN 102

                         90
                 ....*....|....*.
gi 449018383 219 AEEFMTIAQRFHLDEL 234
Cdd:cd18241  103 VHEVLELADRFLLIRL 118
PHA03095 PHA03095
ankyrin-like protein; Provisional
 46-98 3.05e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 3.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 449018383  46 KVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTFVGE 98
Cdd:PHA03095 239 LVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 151-214 3.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 37.92  E-value: 3.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 449018383 151 DVGFRLEGNRcIWAHRVVLAARSPVFEKILEKRTSPGK---------VLRLKHVSTDAFEAFLRYLYTSTVSV 214
Cdd:cd18228   21 DVTIRVQDKI-FRAHKVVLAACSDFFRSKLVGQASPRLvlvspagkcVLDLHHVTVTGFAPLLEYAYTSTLSI 92
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-236 3.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 37.91  E-value: 3.45e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 449018383 164 AHRVVLAARSPVFEKIL---EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELAQ 236
Cdd:cd18211   43 AHKAVLAASSKYFKEVFlneKISDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSE 118
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-215 3.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 37.85  E-value: 3.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 449018383 164 AHRVVLAARSPVFEKILEKRT--SPGKVLRLKHVSTDAFEAFLRYLYTSTVSVR 215
Cdd:cd18223   32 AHKNVLAASSLYFKNAFSSQEiwISSHVLELPDLKAEVFAEILNFIYSSKVVVK 85
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 165-236 4.06e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 38.04  E-value: 4.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 449018383 165 HRVVLAARSPVFEKILEK--RTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHL----DELAQ 236
Cdd:cd18274   38 HRNVLAAISPYFRSMFTSglTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIpslqDQCAQ 115
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 151-234 4.22e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 37.66  E-value: 4.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 151 DVGFRLEGNR--CiwaHRVVLAARSPVFEKIL-----EKRTSPGK--VLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEE 221
Cdd:cd18296   19 DVCFQVEGHRfpC---HKAFFCGRSDYFKALLrdhfaESEENNGSipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYD 95

                         90
                 ....*....|...
gi 449018383 222 FMTIAQRFHLDEL 234
Cdd:cd18296   96 VLYVADMYLLPGL 108
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 150-211 4.51e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 37.14  E-value: 4.51e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 449018383 150 ADVGFRLEGNrCIWAHRVVLAARSPVFEKILEKRTSPGK--VLRLKHVSTDAFEAFLRYLYTST 211
Cdd:cd18360   11 ADVVFKIQGT-TVPAHRAVLVARCEVMAAMFNGNYAEAKsfLVPIYGVSKDTFLSFLEYLYTDS 73
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-212 4.99e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 36.99  E-value: 4.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 449018383 150 ADVGF---RLEGNRCIWAHRVVLAARSPVFEKIL-----EKRTSpgkvLRLKHVSTDAFEAFLRYLYTSTV 212
Cdd:cd18282    8 ADVHFivgPPGGTQRIPAHKYVLATGSSVFYAMFygglaENKNE----IEIPDVEPAAFLNLLRYLYCDEI 74
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 162-236 5.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 37.39  E-value: 5.16e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 449018383 162 IWAHRVVLAARSPVFEKIL--EKRTSPGKVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMTIAQRFHLDELAQ 236
Cdd:cd18339   33 IEAHRVVLAACSPYFCAMFtgDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQ 109
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 23-97 5.17e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.88  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383  23 DERTmtvdglPLHIWCrTPGNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLL-------EAGAVLDPKTF 95
Cdd:PTZ00322 114 DGRT------PLHIAC-ANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSrhsqchfELGANAKPDSF 186


                 ..
gi 449018383  96 VG 97
Cdd:PTZ00322 187 TG 188
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 162-236 5.40e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 37.71  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 162 IWAHRVVLAARSPVFEKILEKRTSPGKVLRLKHVSTDAFE----------AFLRYLYT---------------------- 209
Cdd:cd18284   30 LRCHKAILSARSPFFRNLLQRRIRTGEDRTLSTPTRIVLDesiiprryarVLLHAMYTdsvdlslilrsspsesslsevq 109

                         90       100       110
                 ....*....|....*....|....*....|..
gi 449018383 210 STVSVRVRH-----AEEFMTIAQRFHLDELAQ 236
Cdd:cd18284  110 AIVAGKGPEtrleeAMELYHIARFLEFDILAQ 141
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-238 6.88e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 36.85  E-value: 6.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449018383 147 DDDADVGFRLEGnRCIWAHRVVLAARSPVFEKILEKRTSPG--KVLRLKHVSTDAFEAFLRYLYTSTVSVRVRHAEEFMT 224
Cdd:cd18353   18 PETSDLKFRVDG-KYIHVHKAVLKIRCEHFRTMFQSHWNEDmkEVIEIDQFSYPVYRAFLEYLYTDSVDLPPEDAIGLLD 96

                         90
                 ....*....|....*..
gi 449018383 225 IAQRF---HLDELAQEV 238
Cdd:cd18353   97 LATSYcenRLKKLCQHI 113
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 33-62 8.30e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.19  E-value: 8.30e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 449018383   33 PLHIWCRTPGNLAKVRALVERGADVNAVDE 62
Cdd:pfam00023   5 PLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 42-118 9.60e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.08  E-value: 9.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 449018383  42 GNLAKVRALVERGADVNAVDEHDATPVYYCALTGNAPVLRFLLEAGAVLDPKTfvgervLYAALTPEIKRLLLQYRE 118
Cdd:PLN03192 633 NDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN------TDDDFSPTELRELLQKRE 703
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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