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Conserved domains on  [gi|221044152|dbj|BAH13753|]
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unnamed protein product [Homo sapiens]

Protein Classification

TALPID3 domain-containing protein( domain architecture ID 12173090)

TALPID3 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 1-1217 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


:

Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1888.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152     1 MPVFKEVKVHLLEDAGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETDKH 80
Cdd:pfam15324   26 APVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIKVQSDLEAKVNSVSELLKKLQETDKQ 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152    81 LQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAALKTSSFQPVSMPSSRAVEKY--SV 158
Cdd:pfam15324  106 LQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGSALKAVSLQPSSVTSSRAVEKSgnSS 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   159 KPEHPNLGSCNPSLYnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGN 238
Cdd:pfam15324  186 EDESPAVGSASTSHH-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRDAKISKREPPKEEKENMETSSSKGN 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   239 VRLLEQILNNNDSLTRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEELETTKVTMQKSDDVLHDLGQKEKETN 310
Cdd:pfam15324  265 GRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEPETASVTVQKASDVLQDLGQLKKEMR 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   311 SMV-----------------QPKESLSMLKLPDLP------------------QNSVKLQTTNTTRSVLKDAEKILRGVQ 355
Cdd:pfam15324  345 SLLqtadafpvpnakstrssQSSRSLSPLPTPPPPppapismppvtavslaalSSPSVLQSTQPPRSMLKDAEKILRQVQ 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   356 NNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQDELSRTDYEQKRFDQKNQRTKKG 435
Cdd:pfam15324  425 NNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEIQDELARKDYEQKRFDQKNRRTAKA 504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   436 QNMT--------KDIRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSLQKerKEGLLKATTVIQDEDYMLQVY 507
Cdd:pfam15324  505 QAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQK--KEGPLKSTTSLQDEDYLLQVY 582

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   508 GKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMDSKMKHSVPVlPHGDQQYLF 587
Cdd:pfam15324  583 GKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATKPVKTDSKMQHSVTA-PHQEQQYLF 661

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   588 SPSREMPTFSGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKD 667
Cdd:pfam15324  662 SPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPSSRKPEPGVKKPNIALLEMKSEKKD 741

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   668 PPQLTVQVLPSVDIDSISNSSADV--LSPLSSPKEASPPPVQTWIKTPEIMKVDEEEVKFPGTNFDEIIDVIQEEEKCDE 745
Cdd:pfam15324  742 PPQLTVQVLPSVDIDSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDEEEVKFPGTNFDEVIDVIQDEEKEDE 821

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   746 IPD-SEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPVQQQIAP 824
Cdd:pfam15324  822 IPEfSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLVDWVEQEIMARIISGMFPQQAQADP 901

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   825 SISVSVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNE 904
Cdd:pfam15324  902 DASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIMLGDREAQREPPVAASVPGDLPTKE 981

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   905 TYLParvcTPLATPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICAEKG-DDMPAIMLVNtPTVTPTTTPP 983
Cdd:pfam15324  982 TLLP----TPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPEKGaDTGPAVSLVI-TPTVTPIATP 1055

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   984 PAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVMSVAKDEEPESMDfpAQPPPPEPVPF 1063
Cdd:pfam15324 1056 PPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSVARDEEPESVV--LPASPPEPKPL 1133

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152  1064 MPFPAGTKAPSPSQMPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTLHDA 1143
Cdd:pfam15324 1134 APPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVRALEEGGLFLPNLNDSLSSSLHDA 1213

                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221044152  1144 VEMEDDPPSEGQVIRMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVGELSEGQRPQLTAAAENILMG 1217
Cdd:pfam15324 1214 QEMDYDPPSEGQVIRRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVGELSEGQRPRLTAAAENVLTG 1288
 
Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 1-1217 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1888.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152     1 MPVFKEVKVHLLEDAGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETDKH 80
Cdd:pfam15324   26 APVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIKVQSDLEAKVNSVSELLKKLQETDKQ 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152    81 LQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAALKTSSFQPVSMPSSRAVEKY--SV 158
Cdd:pfam15324  106 LQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGSALKAVSLQPSSVTSSRAVEKSgnSS 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   159 KPEHPNLGSCNPSLYnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGN 238
Cdd:pfam15324  186 EDESPAVGSASTSHH-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRDAKISKREPPKEEKENMETSSSKGN 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   239 VRLLEQILNNNDSLTRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEELETTKVTMQKSDDVLHDLGQKEKETN 310
Cdd:pfam15324  265 GRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEPETASVTVQKASDVLQDLGQLKKEMR 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   311 SMV-----------------QPKESLSMLKLPDLP------------------QNSVKLQTTNTTRSVLKDAEKILRGVQ 355
Cdd:pfam15324  345 SLLqtadafpvpnakstrssQSSRSLSPLPTPPPPppapismppvtavslaalSSPSVLQSTQPPRSMLKDAEKILRQVQ 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   356 NNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQDELSRTDYEQKRFDQKNQRTKKG 435
Cdd:pfam15324  425 NNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEIQDELARKDYEQKRFDQKNRRTAKA 504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   436 QNMT--------KDIRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSLQKerKEGLLKATTVIQDEDYMLQVY 507
Cdd:pfam15324  505 QAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQK--KEGPLKSTTSLQDEDYLLQVY 582

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   508 GKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMDSKMKHSVPVlPHGDQQYLF 587
Cdd:pfam15324  583 GKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATKPVKTDSKMQHSVTA-PHQEQQYLF 661

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   588 SPSREMPTFSGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKD 667
Cdd:pfam15324  662 SPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPSSRKPEPGVKKPNIALLEMKSEKKD 741

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   668 PPQLTVQVLPSVDIDSISNSSADV--LSPLSSPKEASPPPVQTWIKTPEIMKVDEEEVKFPGTNFDEIIDVIQEEEKCDE 745
Cdd:pfam15324  742 PPQLTVQVLPSVDIDSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDEEEVKFPGTNFDEVIDVIQDEEKEDE 821

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   746 IPD-SEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPVQQQIAP 824
Cdd:pfam15324  822 IPEfSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLVDWVEQEIMARIISGMFPQQAQADP 901

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   825 SISVSVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNE 904
Cdd:pfam15324  902 DASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIMLGDREAQREPPVAASVPGDLPTKE 981

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   905 TYLParvcTPLATPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICAEKG-DDMPAIMLVNtPTVTPTTTPP 983
Cdd:pfam15324  982 TLLP----TPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPEKGaDTGPAVSLVI-TPTVTPIATP 1055

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   984 PAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVMSVAKDEEPESMDfpAQPPPPEPVPF 1063
Cdd:pfam15324 1056 PPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSVARDEEPESVV--LPASPPEPKPL 1133

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152  1064 MPFPAGTKAPSPSQMPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTLHDA 1143
Cdd:pfam15324 1134 APPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVRALEEGGLFLPNLNDSLSSSLHDA 1213

                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221044152  1144 VEMEDDPPSEGQVIRMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVGELSEGQRPQLTAAAENILMG 1217
Cdd:pfam15324 1214 QEMDYDPPSEGQVIRRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVGELSEGQRPRLTAAAENVLTG 1288
 
Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 1-1217 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1888.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152     1 MPVFKEVKVHLLEDAGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETDKH 80
Cdd:pfam15324   26 APVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIKVQSDLEAKVNSVSELLKKLQETDKQ 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152    81 LQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAALKTSSFQPVSMPSSRAVEKY--SV 158
Cdd:pfam15324  106 LQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGSALKAVSLQPSSVTSSRAVEKSgnSS 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   159 KPEHPNLGSCNPSLYnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGN 238
Cdd:pfam15324  186 EDESPAVGSASTSHH-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRDAKISKREPPKEEKENMETSSSKGN 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   239 VRLLEQILNNNDSLTRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEELETTKVTMQKSDDVLHDLGQKEKETN 310
Cdd:pfam15324  265 GRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEPETASVTVQKASDVLQDLGQLKKEMR 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   311 SMV-----------------QPKESLSMLKLPDLP------------------QNSVKLQTTNTTRSVLKDAEKILRGVQ 355
Cdd:pfam15324  345 SLLqtadafpvpnakstrssQSSRSLSPLPTPPPPppapismppvtavslaalSSPSVLQSTQPPRSMLKDAEKILRQVQ 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   356 NNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQDELSRTDYEQKRFDQKNQRTKKG 435
Cdd:pfam15324  425 NNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEIQDELARKDYEQKRFDQKNRRTAKA 504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   436 QNMT--------KDIRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSLQKerKEGLLKATTVIQDEDYMLQVY 507
Cdd:pfam15324  505 QAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQK--KEGPLKSTTSLQDEDYLLQVY 582

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   508 GKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMDSKMKHSVPVlPHGDQQYLF 587
Cdd:pfam15324  583 GKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATKPVKTDSKMQHSVTA-PHQEQQYLF 661

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   588 SPSREMPTFSGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKD 667
Cdd:pfam15324  662 SPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPSSRKPEPGVKKPNIALLEMKSEKKD 741

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   668 PPQLTVQVLPSVDIDSISNSSADV--LSPLSSPKEASPPPVQTWIKTPEIMKVDEEEVKFPGTNFDEIIDVIQEEEKCDE 745
Cdd:pfam15324  742 PPQLTVQVLPSVDIDSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDEEEVKFPGTNFDEVIDVIQDEEKEDE 821

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   746 IPD-SEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPVQQQIAP 824
Cdd:pfam15324  822 IPEfSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLVDWVEQEIMARIISGMFPQQAQADP 901

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   825 SISVSVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNE 904
Cdd:pfam15324  902 DASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIMLGDREAQREPPVAASVPGDLPTKE 981

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   905 TYLParvcTPLATPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICAEKG-DDMPAIMLVNtPTVTPTTTPP 983
Cdd:pfam15324  982 TLLP----TPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPEKGaDTGPAVSLVI-TPTVTPIATP 1055

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152   984 PAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVMSVAKDEEPESMDfpAQPPPPEPVPF 1063
Cdd:pfam15324 1056 PPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSVARDEEPESVV--LPASPPEPKPL 1133

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221044152  1064 MPFPAGTKAPSPSQMPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTLHDA 1143
Cdd:pfam15324 1134 APPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVRALEEGGLFLPNLNDSLSSSLHDA 1213

                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221044152  1144 VEMEDDPPSEGQVIRMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVGELSEGQRPQLTAAAENILMG 1217
Cdd:pfam15324 1214 QEMDYDPPSEGQVIRRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVGELSEGQRPRLTAAAENVLTG 1288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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