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Conserved domains on  [gi|221039868|dbj|BAH11697|]
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unnamed protein product [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-217 5.94e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 5.94e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  86 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 165
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221039868 166 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPNI 217
Cdd:COG4886  195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-217 5.94e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 5.94e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  86 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 165
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221039868 166 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPNI 217
Cdd:COG4886  195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
89-215 5.30e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 5.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  89 LYLDANQIEELPKqlfNCQA-LRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKccKCLTIIEASVNPISK 167
Cdd:PRK15370 204 LILDNNELKSLPE---NLQGnIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLP--SALQSLDLFHNKISC 276

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221039868 168 LPDGFTQLLNLTQLYLND--AFLEFLPANFGRL---------------VKLRILELRENHLKTLP 215
Cdd:PRK15370 277 LPENLPEELRYLSVYDNSirTLPAHLPSGITHLnvqsnsltalpetlpPGLKTLEAGENALTSLP 341
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-216 1.26e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  80 FNFERTLEELYLDANQIEELPkQLFNCQALRKLSIPDN---------DLSNL-------------------PTTIASLVN 131
Cdd:cd21340   42 LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNrisvvegleNLTNLeelhienqrlppgekltfdPRSLAALSN 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868 132 -LKELDISKNGVQEfPENIKCCKCLTIIEASVNPISKLPDgftqllnLTQLylndafleflpanFGRLVKLRILELRENH 210
Cdd:cd21340  121 sLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEE-------LLDL-------------LSSWPSLRELDLTGNP 179


                 ....*.
gi 221039868 211 LKTLPN 216
Cdd:cd21340  180 VCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
84-140 5.87e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 5.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 221039868   84 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNL-PTTIASLVNLKELDISKN 140
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-217 5.94e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 5.94e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  86 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 165
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221039868 166 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPNI 217
Cdd:COG4886  195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-215 1.13e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.92  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  86 LEELYLDANqieelpKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 165
Cdd:COG4886   98 LTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQL 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 221039868 166 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLP 215
Cdd:COG4886  172 TDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLP 221
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-217 1.67e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 1.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  64 VLDYSHCSLQQVPKEVFNFERtLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTtIASLVNLKELDISKNGVQ 143
Cdd:COG4886  186 ELDLSNNQITDLPEPLGNLTN-LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLT 263

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221039868 144 EFPENIKCCKcLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPNI 217
Cdd:COG4886  264 DLPPLANLTN-LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-216 5.76e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 5.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  81 NFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNgvqefpENIKCCKCLTIIEA 160
Cdd:COG4886   47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDL 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221039868 161 SVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPN 216
Cdd:COG4886  121 SGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE 176
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
89-215 5.30e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 5.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  89 LYLDANQIEELPKqlfNCQA-LRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKccKCLTIIEASVNPISK 167
Cdd:PRK15370 204 LILDNNELKSLPE---NLQGnIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLP--SALQSLDLFHNKISC 276

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221039868 168 LPDGFTQLLNLTQLYLND--AFLEFLPANFGRL---------------VKLRILELRENHLKTLP 215
Cdd:PRK15370 277 LPENLPEELRYLSVYDNSirTLPAHLPSGITHLnvqsnsltalpetlpPGLKTLEAGENALTSLP 341
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
85-215 3.29e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 3.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  85 TLEELYLDANQIEELPKQLfnCQALRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKCckclTIIEASV-- 162
Cdd:PRK15370 242 TIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS----GITHLNVqs 313

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 221039868 163 NPISKLPDgfTQLLNLTQLYLNDAFLEFLPANFGRlvKLRILELRENHLKTLP 215
Cdd:PRK15370 314 NSLTALPE--TLPPGLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLP 362
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
86-176 8.13e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 8.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  86 LEELYLDANQIEELPKQLfnCQALRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKCckCLTIIEASVNPI 165
Cdd:PRK15370 327 LKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLPA--ALQIMQASRNNL 400

                         90
                 ....*....|.
gi 221039868 166 SKLPDGFTQLL 176
Cdd:PRK15370 401 VRLPESLPHFR 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-215 2.08e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  85 TLEELYLDANQIE-ELPkQLFNCQALRKLSIPDNDLSN-LPTTIASLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEAS 161
Cdd:PLN00113 453 SLQMLSLARNKFFgGLP-DSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLS 531

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221039868 162 VNPIS-KLPDGFTQLLNLTQLYLNDAFLEF-LPANFGRLVKLRILELRENHLK-TLP 215
Cdd:PLN00113 532 HNQLSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVNISHNHLHgSLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 57-211 3.87e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  57 GEEEIISVLDYSHCSLQ-QVPKEVFNFERtLEELYLDANQIE-ELPKQLFNCQALRKLSIPDNDLS-NLPTTIASLVNLK 133
Cdd:PLN00113 353 GKHNNLTVLDLSTNNLTgEIPEGLCSSGN-LFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVY 431

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868 134 ELDISKNGVQefpENIKCCK----CLTIIEASVNPIS-KLPDGFTQlLNLTQLYLN-DAFLEFLPANFGRLVKLRILELR 207
Cdd:PLN00113 432 FLDISNNNLQ---GRINSRKwdmpSLQMLSLARNKFFgGLPDSFGS-KRLENLDLSrNQFSGAVPRKLGSLSELMQLKLS 507


                 ....
gi 221039868 208 ENHL 211
Cdd:PLN00113 508 ENKL 511
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-216 1.26e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  80 FNFERTLEELYLDANQIEELPkQLFNCQALRKLSIPDN---------DLSNL-------------------PTTIASLVN 131
Cdd:cd21340   42 LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNrisvvegleNLTNLeelhienqrlppgekltfdPRSLAALSN 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868 132 -LKELDISKNGVQEfPENIKCCKCLTIIEASVNPISKLPDgftqllnLTQLylndafleflpanFGRLVKLRILELRENH 210
Cdd:cd21340  121 sLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEE-------LLDL-------------LSSWPSLRELDLTGNP 179


                 ....*.
gi 221039868 211 LKTLPN 216
Cdd:cd21340  180 VCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-211 6.39e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 6.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868  74 QVPKEVFNFeRTLEELYLDANQIE-ELPKQLFNCQALRKLSIPDNDLS-------------------------NLPTTIA 127
Cdd:PLN00113 251 PIPSSLGNL-KNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfsnnftgKIPVALT 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221039868 128 SLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEASVNPIS-KLPDGFTQLLNLTQLYLNDAFLEF-LPANFGRLVKLRIL 204
Cdd:PLN00113 330 SLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRV 409


                 ....*..
gi 221039868 205 ELRENHL 211
Cdd:PLN00113 410 RLQDNSF 416
LRR_8 pfam13855
Leucine rich repeat;
84-140 5.87e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 5.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 221039868   84 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNL-PTTIASLVNLKELDISKN 140
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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