|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
1-395 |
0e+00 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 658.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 1 MNLSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAI 80
Cdd:PRK10054 1 MNLSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 81 TAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSI 160
Cdd:PRK10054 81 TAFASGFIAIPLVNNVTLVVLFFALINCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 161 NLPFWLAAICSAFPMLFIQIWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIADGD 240
Cdd:PRK10054 161 NLPFWLAAICSAFPLVFIQIWVQRSEKAIATETGSVWSPSVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVVADSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 241 FAEKVVAVVLPVNAAMVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEY 320
Cdd:PRK10054 241 FAEKVVAVVLPVNAAMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEY 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209912080 321 MLIDHIAPPGMKASYFSAQSLGWLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLMLKGIRARPWGQPALC 395
Cdd:PRK10054 321 MLIDHIAPPGMKASYFSAQSLGWLGAAINPLVSGVILTTLPPWSLFVILALAIVAAWLLMLKGMRARPWGQPALC 395
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-382 |
1.26e-73 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 234.04 E-value: 1.26e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd17329 13 LGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSINLPFWLAAICSAFPMLFIQI 180
Cdd:cd17329 93 IALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 181 WVKRSEKII--ATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIadGDFAEKVVAVVLPVNAAMVV 258
Cdd:cd17329 173 LLPETRPKRraAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI--LGLGESLLGLLLALNALLIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 259 TLQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSgNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSA 338
Cdd:cd17329 251 LLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFA-NTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 209912080 339 QSLGW-LGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLMLK 382
Cdd:cd17329 330 YALAWgLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-381 |
1.53e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.03 E-value: 1.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTIYLsRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd17325 10 LGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SINLPFWLAAICSAFPMLFIQ 179
Cdd:cd17325 89 LARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAALALLALVLAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 180 IWVKRSEKIIATETGSVWSP----KVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMviADGDFAEKVVAVVLPVNAA 255
Cdd:cd17325 169 LLLPEPRPPPNKRAVSAARLrsglRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA--ELGGLSPAQIGLLFGAQGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 256 MVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGMsAAVFTVGEIIYAPGEYMLIDHIAPPGMKASY 335
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLL-LALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 209912080 336 FSAQSLGW-LGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLML 381
Cdd:cd17325 326 MGLFNTAFsLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-348 |
1.60e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 91.57 E-value: 1.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTiYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:COG2814 24 LGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SINLPFWLAAICSAFPMLFIQ 179
Cdd:COG2814 103 AARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 180 IWVKRSEKIIATETGSvwSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIAdgDFAEKVVAVVLPVNAAMVVT 259
Cdd:COG2814 183 RLLPESRPAARARLRG--SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL--GLSASAAGLLLALFGLGGVL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 260 LQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGmSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSA- 338
Cdd:COG2814 259 GALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLL-ALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLy 337
|
330
....*....|
gi 209912080 339 QSLGWLGAAI 348
Cdd:COG2814 338 NSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-348 |
6.36e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.23 E-value: 6.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:pfam07690 10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SINLPFWLAAICSAFPMLFIQ 179
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 180 IWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIADG-DFAEKVVAVVLPVNAAMVV 258
Cdd:pfam07690 170 LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVlGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 259 TLQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSGN--SLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYF 336
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329
|
330
....*....|..
gi 209912080 337 SAQSLGWLGAAI 348
Cdd:pfam07690 330 GLYNTAGSLGGA 341
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-381 |
4.46e-15 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 76.05 E-value: 4.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 26 TLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADK-FDKKRYMLLAITAFASGFIAIPLVNN----VTLVV 100
Cdd:cd17471 15 VLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNywvlLLVGV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 101 LFFALINCAYS-VFATVLKawFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SINLPFWLAAICSAFpMLFI 178
Cdd:cd17471 95 VLLSLGAAAFPqLFALARE--YADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVlGFTGLFLLAALLYLV-VALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 179 QIWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYvmVIADGDFAEKVVAVVLPVNAAMVV 258
Cdd:cd17471 172 VLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLY--VTNELGGSESWVGLLFGLAAALEI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 259 TLQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSGNSLLLWG---MSAAVFTvgeIIYAPGEYMLIDHIAP-PGMKAS 334
Cdd:cd17471 250 PIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIAlqlLNAIFIG---ITAGLGISYFQDLMPGqPGLATT 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 209912080 335 -YFSAQSLGWLGAAinpLVSGVVLTSLPPSSLFVILALVIIAAWVLML 381
Cdd:cd17471 327 lYSNASRIGSLLGG---LLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-379 |
9.63e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.83 E-value: 9.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 34 LSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVF 113
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 114 ATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSINLPFWLAAICSAFPMLFIQIWVKRS-EKIIATE 192
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPkEKAKSSS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 193 TGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVTLQysVGRRLNPA- 271
Cdd:cd17474 185 ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF--VGRLLKKRf 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 272 NIRALMTAGTLCFVIGLVGFIFSGNSLLLWgMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSA-QSLGWLGAAINP 350
Cdd:cd17474 263 GARRILVIGLLLYALSLLLLGFVPSLALLL-IAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLyNFVRFLGQAVGP 341
|
330 340
....*....|....*....|....*....
gi 209912080 351 LVSGVVLTSLPPSSLFVILALVIIAAWVL 379
Cdd:cd17474 342 LLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
29-381 |
1.75e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 71.47 E-value: 1.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 29 FMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKR-----YMLLAITAFASGFIAIPLV------NNVT 97
Cdd:COG2211 32 YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTApdlsptGKLI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 98 LVVLFFALINCAYSVFATVLKAWFADnLSSTSK--TKIFSINYTMLNIGWTIGPPLGTLLV-------MQSINLPFWLAA 168
Cdd:COG2211 112 YALVTYLLLGLAYTLVNIPYSALGAE-LTPDYEerTRLSSWRFAFAGLGGLLASVLPPPLVaafggdaALGYRLTALIFA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 169 ICSAFPMLFIQIWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIAdgDFAEKVVAV 248
Cdd:COG2211 191 VLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAALVGL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 249 VLPVNAAMVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSG-NSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIA 327
Cdd:COG2211 269 LLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 328 PPG-------MKASYFSAQSLGW-LGAAINPLVSGVVLTSL--------PPSSLFVILALVIIAAWVLML 381
Cdd:COG2211 349 DYDewktgrrREGLYFGIFTFAIkLGQALAGALAGLLLALFgyvagaaqSPSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-381 |
2.02e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.70 E-value: 2.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 27 LPFMTIYLSrQYSLSVDLIGYAMTIAlTIGVVFSLGF-GILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFAL 105
Cdd:cd17489 16 LPVLPLYAH-DLGGSEAVAGLVVGLF-TLAALLARPFaGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 106 INCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SINLPFWLAAICSAFPMLFIQIWVKR 184
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHlGFAVLFIVAAVLALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 185 SEKIIATETGSVWSPKVLLQDKALLwFTCSGFLASFVSDAFASCISQYVMVIADgdfaeKVVAVVLPVNAAMVVTLQYSV 264
Cdd:cd17489 174 PPVAAEEAEAGTRAFRRLVEKKVLP-PALILFLASIAYGAISTFLPLYAAERGI-----SNAGLFFTVYAIALLLSRPFS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 265 GRRLNPANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGmSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQSLGW- 343
Cdd:cd17489 248 GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL-AAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFd 326
|
330 340 350
....*....|....*....|....*....|....*...
gi 209912080 344 LGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLML 381
Cdd:cd17489 327 LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-169 |
4.99e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.91 E-value: 4.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 3 LSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITA 82
Cdd:cd17325 195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 83 FASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SIN 161
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfGFA 354
|
....*...
gi 209912080 162 LPFWLAAI 169
Cdd:cd17325 355 TPFLAAAA 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-381 |
1.67e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.22 E-value: 1.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTIYLsRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd06174 10 LARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSIN---LPFWLAAICSAFPMLF 177
Cdd:cd06174 89 LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALALLAAIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 178 IQIWVK------RSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIadGDFAEKVVAVVLP 251
Cdd:cd06174 169 LLLVVPdppesaRAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL--GGLSVAVAGLLLS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 252 VNAAMVVTLQYSVGRRLN-PANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGMsAAVFTVGEIIYAPGEYMLIDHIAPPG 330
Cdd:cd06174 247 LFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL-LLLLGFGLGGLLPLSFALIAELFPPE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 209912080 331 MKASYFSAQSL-GWLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLML 381
Cdd:cd06174 326 IRGTAFGLLNTfGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-382 |
1.70e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 67.99 E-value: 1.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTIYLSRQYSLSVD--LIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVtL 98
Cdd:cd17330 10 LGFGIVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL-W 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 99 VVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLV-MQSINLPFWLAAICSAFPMLF 177
Cdd:cd17330 89 LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStPYGYALPFLVAAALALLNLVL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 178 IQIWVKRSEKIIATetgsvwspkvllqdKALLWFTCSGFLASFVSDAfascisqyvmvIADGDFAEKVVAVVLPVNAAMV 257
Cdd:cd17330 169 VLFFLPPLRRLLLV--------------YFLIALAFAGLESVFSLFL-----------KDRFGFSPSQIGLLLALVGIAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 258 VTLQYSVGRRLNPA-NIRALMTAGTLCFVIGLVGFIFSGNSLLLWgMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYF 336
Cdd:cd17330 224 ILAQLLLIPRLAKRlGERKLLRLGLLLAIIGLLLLPFASSVPLLV-LAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 209912080 337 S-AQSLGWLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLMLK 382
Cdd:cd17330 303 GiIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
27-378 |
4.76e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 66.86 E-value: 4.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 27 LPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALI 106
Cdd:cd17472 16 LPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 107 -NCAYSvfaTVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLV-MQSINLPFWLAAICSAFPMLFIQIWVKR 184
Cdd:cd17472 96 gSGAIS---SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAaHLGVSGLFLITAILSLVSLLILLFFVPD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 185 SEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIADG-DFAEKV-VAVVLPVNAAMVVTLQY 262
Cdd:cd17472 173 PPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGkGQLWKVyLPAILIGFILMVPFVIY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 263 SVGRRlnpaNIRALMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFS-AQSL 341
Cdd:cd17472 253 AEKKG----KMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGiYNTS 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 209912080 342 GWLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWV 378
Cdd:cd17472 329 QFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-381 |
1.01e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.57 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 34 LSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVF 113
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 114 ATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SINLPFWLAAICSAFPMLFIQIWVKRSEKIIATE 192
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 193 TGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIADGDfAEKVVAVVLPVNAAMVVTLQYsVGRRLNPAN 272
Cdd:cd17324 185 LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFS-SSAIIGLLLLFGVAGVVGSPL-AGRLADRGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 273 IRALMTAGTLCFVIGLVgFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAP--PGMKASYFSAqsLGWLGAAINP 350
Cdd:cd17324 263 RRALLIALLLLAAALLL-LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPeaRGLASSLYLA--AYNLGGALGA 339
|
330 340 350
....*....|....*....|....*....|.
gi 209912080 351 LVSGVVLTSLPPSSLFVILALVIIAAWVLML 381
Cdd:cd17324 340 ALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-382 |
2.70e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 2.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 41 SVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLV-----NNVTLVVLFFALINCAYSVFAT 115
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 116 VLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SINLPFWLAAIC---SAFPMLFIQIWVKRS--EKII 189
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALlGPGGAFAINALSfllSALLLLFIRRPPPAApgESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 190 ATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIADGDfaEKVVAVVLPVNAAMVVTLQYSVGRRLN 269
Cdd:cd06173 192 LLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG--AAGYGLLLAAFGVGALLGALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 270 PANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGMsAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQ-SLGWLGAAI 348
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAA-LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYnALNSGAMPL 348
|
330 340 350
....*....|....*....|....*....|....
gi 209912080 349 NPLVSGVVLTSLPPSSLFVILALVIIAAWVLMLK 382
Cdd:cd06173 349 GALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
40-381 |
1.78e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 58.71 E-value: 1.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 40 LSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLL---AITAFASGFIAipLVNNVTLVVLFFALINCAYSVFATV 116
Cdd:cd17370 31 ASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIlgyGLSALAKPLLA--LAGSWQLVLLLRILERLGKGIRTPP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 117 LKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSIN---LPFWLAAICSAFPMLFIQIWVKRSEKIIATET 193
Cdd:cd17370 109 RDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyrTIFLLAAIPALLALLILLFVVKEYPRPPKLRK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 194 GSVWSPKVLLqDKALLWFTCSGFL--ASFVSDAFascisqyvMVIADGDFAEKVVAVVLPVNAAMVV--TLQYSVGRRLN 269
Cdd:cd17370 189 KSKKTSLKKL-PKAFWLYLLAVALfaLGNFSFAF--------LILRAQELGLSAALIPLLYALFNLVyaLAAYPAGRLSD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 270 PANIRALMTAGTLCFVIGLVGFIFSGNSLLLWgMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKAS----YFSAQSLGWLG 345
Cdd:cd17370 260 RIGRKKLLILGYLSLALAYLGFALGSSLWLLL-LGFILWGLYMGAQESIERAAVADLVPAELRGTayglFNTVVGIGWLL 338
|
330 340 350
....*....|....*....|....*....|....*.
gi 209912080 346 AAinpLVSGVVLTSLPPSSLFVILALVIIAAWVLML 381
Cdd:cd17370 339 AS---LIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-311 |
3.29e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.95 E-value: 3.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 33 YLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSV 112
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 113 F---ATVLkawfADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSINLPFW----LAAICSAFPMLFIQIWVKRS 185
Cdd:cd17478 101 FhpeGARL----ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLilliIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 186 EKiiATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVI-ADGDFAEKVVAVVLPVNAAMVVTLQYsV 264
Cdd:cd17478 177 AK--KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRgYSLVFAGLLLSLFLFAGAIGTLIGGP-L 253
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 209912080 265 GRRLNPaniRALMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVG 311
Cdd:cd17478 254 SDRFGR---RRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLF 297
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-389 |
9.81e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.79 E-value: 9.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 33 YLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSV 112
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 113 FATVLKAWFADnLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSINLP-----FWLAAICSAFPMLFIQIWVKRSEK 187
Cdd:COG0738 113 LDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSwhlpyLILAVLLLLLALLFLRSKLPEIEE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 188 IIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFASCISQYVMviADGDFAEKVVAVVLPVNAAMVVTLQYSVGRR 267
Cdd:COG0738 192 EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK--DVLGLSEATAALGLSLFWGGMTIGRFLGGFL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 268 LNPANIRALMTAGTLCFVIGLVGFIFSGN------SLLLWGMSAAVF---TVGEIIYAPGEYmlidhiapPGMKASYFSA 338
Cdd:COG0738 270 LKRFGPVRLLRLSALLAAVGLLLALLAPGpwlaliGLALVGLGLSLMfptIFSLALDGLGKR--------TAAAVSAVLI 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 209912080 339 qsLGWLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLMLKGIRARPW 389
Cdd:COG0738 342 --MGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-381 |
1.82e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.66 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 44 LIGYAMTI-ALTIgVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFA 122
Cdd:cd17473 36 LVPLLLTLpALFI-ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 123 DNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSINLPFWLAAIcsAFPMLFIQIWVKRSEKIIATETGSVWSPKVL 202
Cdd:cd17473 115 DYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLL--ALPVLILVLLFLPEPARKSKSAASPGAATAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 203 LQDKALLWFTCsgFLASFVSDAFASCISQYVMVIAD-GDFAEKVVAVVLPVNAAMVVTLQYSVGRRLNPANIRALMTAGT 281
Cdd:cd17473 193 ALPWKRVLPIY--FLAFLAMLLFYVIPIQLPFLLQErGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 282 LCFVIGLVGFIFSGN-SLLLWGMSAAVFTVGEIIyaPGEYMLIDHIAPPGMKASYFSA-QSLGWLGAAINPLVSGVVLTS 359
Cdd:cd17473 271 ALMALGFLLLALASGlWVVLLGAILAGLGFGLLL--PTLNSWAMSLVPPELRGRAMGIvTSAFFLGQFLSPLVLGPLVNL 348
|
330 340
....*....|....*....|...
gi 209912080 360 LP-PSSLFVILALVIIAAWVLML 381
Cdd:cd17473 349 TGgLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
32-178 |
1.41e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.93 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 32 IYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYS 111
Cdd:cd17370 223 ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMG 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 209912080 112 VFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPL-GTLLVMQSINLPFWLAAICSAFPMLFI 178
Cdd:cd17370 303 AQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIaGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-187 |
1.48e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.95 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 29 FMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFAS--GFIAIPLVNNVTLVVLFFALI 106
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAalALLLLALLPSPALAIALLFLA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 107 NCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPL-GTLLVMQSINLPFWLAAICSAFPMLFIQIWVKRS 185
Cdd:COG2271 282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLvGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
..
gi 209912080 186 EK 187
Cdd:COG2271 362 RK 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-380 |
1.56e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.95 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTIYLSRQySLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd17477 10 LGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTlLVMQSINLPFWLAAICSAFPMLFiqI 180
Cdd:cd17477 89 LLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAAVLLLLALVP--L 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 181 WVKRSEKIIATETGSVWSPKVLLQDKALLwftCSGFLASFVSDAFASCISQYVMVIadgDFAEKVVAVVLPVNAAMVVTL 260
Cdd:cd17477 166 LLTRRAAPEIEEAESISLRRLLRIAPLAL---LGAFVAGFLEGAFYSLLPLYGLRL---GLSVAQAALLLAAFVLGGLLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 261 QYSVGRRLNPANIRALMTAGTLCFVIGLVGF-IFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQ 339
Cdd:cd17477 240 QWPLGWLADRFDRRRVLLGCALLGALAALLLpLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALL 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 209912080 340 SLGWLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLM 380
Cdd:cd17477 320 LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-388 |
4.08e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.41 E-value: 4.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 25 ATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFA 104
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 105 LINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQ-SINLPFWLAAICSAFPMLFiqiwvk 183
Cdd:COG2271 107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAfGWRAAFLILGLPGLLLALL------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 184 rsekiiatetgsvwspkvllqdkALLWFTCSGFLASFVSDAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVTLqyS 263
Cdd:COG2271 181 -----------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSL--L 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 264 VGR---RLNPANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVGeiIYAPGEYMLIDHIAPPGMKASYFS-AQ 339
Cdd:COG2271 236 GGWlsdRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG--GAFGLLWALAAELFPKKARGTASGlVN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 209912080 340 SLGWLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLMLKGIRARP 388
Cdd:COG2271 314 TFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-392 |
5.16e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.42 E-value: 5.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 26 TLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFAL 105
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 106 INCA----YSVFATVLKAWFADNLsstsKTKIFSINYTMLNIGWTIGPPLGTLLV-MQSINLPFWLAAICSAFPMLFIQI 180
Cdd:COG2223 103 LGIGgggsFAVGIALVSKWFPPDR----RGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 181 WVKRS-EKIIATETGSVWSPKVLLQDKA--LLWFTCSGFLASFVsdAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMV 257
Cdd:COG2223 179 FLRDPpAGAAAAAKASLRDQLEALRDPRfwLLSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGAL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 258 VTLQY-SVGRRLNPANIRALMTAGTLCFVIGLvgFIFSGNSLLLWGMSAAVFTVGEIIYAPGeYMLIDHIAPPGMKASYF 336
Cdd:COG2223 257 GRPLGgWLSDRIGGRRVLLIVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAV-FALVPDIFPTKNAGAVY 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 209912080 337 SAQSLGW-LGAAINPLVSGVVL--TSLPPSSLFVILALVIIAAWVLMLKGIRARPWGQP 392
Cdd:COG2223 334 GLVGAAGgLGGFLGPLLFGALLdaTGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-383 |
3.36e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.72 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 34 LSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSV- 112
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVg 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 113 ---FATVLKAWFADNLSStsktkIFSINYTMLNIGWTIGPPLGT-LLVMQSINLPFWLAAICSAFPMLFIqIWVKRSEKI 188
Cdd:COG2807 124 nvlLPGLIKRWFPDRVGL-----MTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAVWALLALLALLLW-LPLLRRRPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 189 IATETGSVWSPKVLLQDKALLWFTCSGFLASFvsdAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVTLQYSVG--- 265
Cdd:COG2807 198 AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSL---LYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPlla 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 266 RRLnpANIRALMTAGTLCFVIGLVGFIFS-GNSLLLWGMSAAVFTVGEIIYApgeYMLIDHIAPPGMKASYFS--AQSLG 342
Cdd:COG2807 275 DRL--GDRRPLLLLLGLLGLAGLLGLLLApGSLPWLWAVLLGLGQGGLFPLA---LTLIGLRARTPAEAAALSgmAQSVG 349
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 209912080 343 WLGAAINPLVSGVV--LTSLPPSSLFVILALVIIAAWVLMLKG 383
Cdd:COG2807 350 YLLAALGPLLVGALhdATGSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-156 |
6.49e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 6.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLV--NNVTL 98
Cdd:COG2211 242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWL 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209912080 99 VVLFFALINCAYSVFATVLKAWFADNL-SSTSKT------KIFSINYTMLNIGWTIGPPLGTLLV 156
Cdd:COG2211 322 LLVLAALAGIGLGAILVLPWAMLADVVdYDEWKTgrrregLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-183 |
7.07e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 42.64 E-value: 7.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 57 VVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSI 136
Cdd:TIGR00880 12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGL 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 209912080 137 NYTMLNIGWTIGPPLGTLLVMQSI-NLPFWLAAICSAFPMLFIQIWVK 183
Cdd:TIGR00880 92 MSAGIALGPLLGPPLGGVLAQFLGwRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
46-381 |
8.17e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.22 E-value: 8.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 46 GYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNL 125
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 126 SSTSKTKIFSINYTmlniGWTIGPPLGTLLVMQSINLP---------FWLAAIcSAFPMLFIQIWVKRSEKIIATETGSV 196
Cdd:cd17371 117 PARHRGKALGYVQS----GWAVGWLLATLLAALLFPLLppeiawrvlFLLGAL-PALLVLFIRRFVKEPPQWQAARAARR 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 197 WSPK----VLLQDKALLWFTCSGFLASFVSDAFASCISQYVMVIADG--DFAEKVVAVVLPV-NAAMVV------TLQYS 263
Cdd:cd17371 192 HFADrpslRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGerGLSFEGSAGYLVVtILGGFLgylaggFLADR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 264 VGRRlnpaNIRALMTAGTLCFVIgLVGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMliDHIAPPGMKAS-YFSAQSLG 342
Cdd:cd17371 272 IGRR----NNFALFALGSAISIL-LYFFLPLSPTLILILGFPLGFFASGPFSGMGAYL--TELFPTAVRATaQGFCYNVG 344
|
330 340 350
....*....|....*....|....*....|....*....
gi 209912080 343 WLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLML 381
Cdd:cd17371 345 RIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
29-122 |
1.15e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 29 FMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKR-YMLLAITAFASGFIAIPLV---NNVTLVVLFFA 104
Cdd:cd17369 250 FALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPvYLAGALLAALFAFPFFWLLdtgSTWLIVLAAVV 329
|
90
....*....|....*...
gi 209912080 105 LINCAYSVFATVLKAWFA 122
Cdd:cd17369 330 VLGVLHGMMYGPQAAFLA 347
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-376 |
1.17e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 22 GRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVL 101
Cdd:cd17355 17 GIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 102 FFALI------NCAYSVFATVLKAWFAdnlssTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQsinLPF-----WLAAIC 170
Cdd:cd17355 97 LWGLLggggagTLAAVAFATVAAWWFE-----RRRGLALGILTAGGGLGSLVFLPLGAALIEA---FGWrtallVLALLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 171 SAFPMLFIQIWVKRSEKI------IATETGSVWSPKVLLQDKALLWFTCSGFLASFVSDAFascISQYVMVIADGDFAEK 244
Cdd:cd17355 169 LLVLVPVLLLLRRRPADLalraydDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGL---IVHLVPYLADRGISPA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 245 VVAVVLPVNAAMVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLID 324
Cdd:cd17355 246 AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 209912080 325 HIAPPGMKASYFSAQSLGW-LGAAINPLVSGVVLTSLP--PSSLFVILALVIIAA 376
Cdd:cd17355 326 RYFGARSYGTLFGLVFAPHqLGSALGPWLGGLLYDRTGsyTAAWALAVALGLIAA 380
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
37-380 |
2.26e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 37 QYSLSVDLIGYAmtialtIGVVFslgFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATV 116
Cdd:cd17320 37 QLTLSAYLLGFA------LGQLL---YGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 117 LKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVM----QSINLPFWLAAICSAFPMLFIQIWVKRSEKIIATE 192
Cdd:cd17320 108 ARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLffgwRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 193 TGSVWSPKVLLQDKAllwFTCSGFLASFVSDAFASCISQY-VMVIADGDFAEKVVAVVLPVNAAMVVTLQYSVGRRLNPA 271
Cdd:cd17320 188 SSLLRAYKRVLKNRR---FLGYALALGLSFAGLFAYLAAApFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 272 NIRALMTAGTLCFVIGLVGFIFSGnslLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQSLGWLGAAINPL 351
Cdd:cd17320 265 GPRRLLRLGLLLLLAAALVLLLAA---LLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFL 341
|
330 340 350
....*....|....*....|....*....|....*...
gi 209912080 352 VSGVVL---------TSLPPSSLFVILALVIIAAWVLM 380
Cdd:cd17320 342 IGALAGalvgllpngTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-177 |
2.35e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 21 IGRGATLPFMTIYLSrqySLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd17489 208 IAYGAISTFLPLYAA---ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLL 284
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 209912080 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLV-MQSINLPFWLAAICSAFPMLF 177
Cdd:cd17489 285 LAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAeLFGYRAMFLLAAVVVLLALVL 362
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
274-388 |
6.18e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209912080 274 RALMTAGTLCFVIGLVGFIFSgNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQSLGW-LGAAINPLV 352
Cdd:COG2814 75 RRVLLLGLLLFALGSLLCALA-PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLgLGPALGPLL 153
|
90 100 110
....*....|....*....|....*....|....*.
gi 209912080 353 SGVVLTSLPPSSLFVILALVIIAAWVLMLKGIRARP 388
Cdd:COG2814 154 GGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
|
|
| |
