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Conserved domains on  [gi|194380160|dbj|BAG63847|]
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unnamed protein product [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 518-605 8.25e-39

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


:

Pssm-ID: 465083  Cd Length: 87  Bit Score: 139.16  E-value: 8.25e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   518 KQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSS-SQEKDPKIKTETSEEGSgdLDNLD 596
Cdd:pfam16279    1 KQEQLSPKKKKNNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSkSEKEESKIKTEPPDELS--LDNLD 78


                   ....*....
gi 194380160   597 AILGDLTSS 605
Cdd:pfam16279   79 AILGDLRNS 87
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 254-367 2.10e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


:

Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 136.41  E-value: 2.10e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   254 YGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMAS-----SGNTGNHSFSSSSLSALQAISEGV 328
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHRGSPKMPANQFSPGMGLHSPMGSvssggSGGGGSRTYSSSSLNALQAISEGV 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 194380160   329 GTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLG 367
Cdd:pfam16665   81 GNSLGSSLTSPVPKQDSSPNINSTQQKKEGSSDSKSPSS 119
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 411-499 8.54e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


:

Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 104.78  E-value: 8.54e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   411 KGHKKLLQLLTCSSDDRG-HSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSstsNMHGSLLQEKHRILHKLLQNGNS 489
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGpSPLRSHADADTDCKDSLAGVTSPSSGVSSSSGSSC---PSHHSSLQEKHKILHRLLQNGNS 77

                           90
                   ....*....|
gi 194380160   490 PAEVAKITAE 499
Cdd:pfam08832   78 PDDVAKLTAE 87
PAS_11 super family cl37882
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 67-170 1.68e-21

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


The actual alignment was detected with superfamily member pfam14598:

Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 90.82  E-value: 1.68e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160    67 ESFITRHDLSGKVVNIDTnslRSSMRPGFED--IIRRCIQRFFSLNDgQSWSQKRH-----YQEET--PVYRFSLADGTI 137
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD-LRTAKSHLreiiqTRGRAtsPSYRLRLRDGDF 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 194380160   138 VTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNG 170
Cdd:pfam14598   78 LSVHTKSKLFLNQNSNQQPFIMCTHTILREENA 110
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 840-886 2.80e-21

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


:

Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 87.85  E-value: 2.80e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 194380160   840 EGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPK 886
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVGQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1085-1142 1.57e-19

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


:

Pssm-ID: 462174  Cd Length: 58  Bit Score: 83.28  E-value: 1.57e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 194380160  1085 SMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMM 1142
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
 
Name Accession Description Interval E-value
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 518-605 8.25e-39

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 139.16  E-value: 8.25e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   518 KQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSS-SQEKDPKIKTETSEEGSgdLDNLD 596
Cdd:pfam16279    1 KQEQLSPKKKKNNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSkSEKEESKIKTEPPDELS--LDNLD 78


                   ....*....
gi 194380160   597 AILGDLTSS 605
Cdd:pfam16279   79 AILGDLRNS 87
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 254-367 2.10e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 136.41  E-value: 2.10e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   254 YGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMAS-----SGNTGNHSFSSSSLSALQAISEGV 328
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHRGSPKMPANQFSPGMGLHSPMGSvssggSGGGGSRTYSSSSLNALQAISEGV 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 194380160   329 GTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLG 367
Cdd:pfam16665   81 GNSLGSSLTSPVPKQDSSPNINSTQQKKEGSSDSKSPSS 119
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 411-499 8.54e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 104.78  E-value: 8.54e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   411 KGHKKLLQLLTCSSDDRG-HSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSstsNMHGSLLQEKHRILHKLLQNGNS 489
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGpSPLRSHADADTDCKDSLAGVTSPSSGVSSSSGSSC---PSHHSSLQEKHKILHRLLQNGNS 77

                           90
                   ....*....|
gi 194380160   490 PAEVAKITAE 499
Cdd:pfam08832   78 PDDVAKLTAE 87
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 67-170 1.68e-21

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 90.82  E-value: 1.68e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160    67 ESFITRHDLSGKVVNIDTnslRSSMRPGFED--IIRRCIQRFFSLNDgQSWSQKRH-----YQEET--PVYRFSLADGTI 137
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD-LRTAKSHLreiiqTRGRAtsPSYRLRLRDGDF 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 194380160   138 VTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNG 170
Cdd:pfam14598   78 LSVHTKSKLFLNQNSNQQPFIMCTHTILREENA 110
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 840-886 2.80e-21

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 87.85  E-value: 2.80e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 194380160   840 EGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPK 886
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVGQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1085-1142 1.57e-19

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 83.28  E-value: 1.57e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 194380160  1085 SMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMM 1142
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
 
Name Accession Description Interval E-value
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 518-605 8.25e-39

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 139.16  E-value: 8.25e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   518 KQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSS-SQEKDPKIKTETSEEGSgdLDNLD 596
Cdd:pfam16279    1 KQEQLSPKKKKNNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSkSEKEESKIKTEPPDELS--LDNLD 78


                   ....*....
gi 194380160   597 AILGDLTSS 605
Cdd:pfam16279   79 AILGDLRNS 87
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 254-367 2.10e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 136.41  E-value: 2.10e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   254 YGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMAS-----SGNTGNHSFSSSSLSALQAISEGV 328
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHRGSPKMPANQFSPGMGLHSPMGSvssggSGGGGSRTYSSSSLNALQAISEGV 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 194380160   329 GTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLG 367
Cdd:pfam16665   81 GNSLGSSLTSPVPKQDSSPNINSTQQKKEGSSDSKSPSS 119
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 411-499 8.54e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 104.78  E-value: 8.54e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160   411 KGHKKLLQLLTCSSDDRG-HSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSstsNMHGSLLQEKHRILHKLLQNGNS 489
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGpSPLRSHADADTDCKDSLAGVTSPSSGVSSSSGSSC---PSHHSSLQEKHKILHRLLQNGNS 77

                           90
                   ....*....|
gi 194380160   490 PAEVAKITAE 499
Cdd:pfam08832   78 PDDVAKLTAE 87
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 67-170 1.68e-21

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 90.82  E-value: 1.68e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380160    67 ESFITRHDLSGKVVNIDTnslRSSMRPGFED--IIRRCIQRFFSLNDgQSWSQKRH-----YQEET--PVYRFSLADGTI 137
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD-LRTAKSHLreiiqTRGRAtsPSYRLRLRDGDF 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 194380160   138 VTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNG 170
Cdd:pfam14598   78 LSVHTKSKLFLNQNSNQQPFIMCTHTILREENA 110
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 840-886 2.80e-21

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 87.85  E-value: 2.80e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 194380160   840 EGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPK 886
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVGQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1085-1142 1.57e-19

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 83.28  E-value: 1.57e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 194380160  1085 SMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMM 1142
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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