|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
1-401 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 655.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd17343 8 MFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALC 160
Cdd:cd17343 88 SSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 161 VVVSFLCLLLIHNEPADVGLRNLDPMPSEGK-KGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEK 239
Cdd:cd17343 168 VVMSVVCLLFIKNEPSDVGLNNIEEEESKGKkKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 240 GQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLG 319
Cdd:cd17343 248 GQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSSELFILLLG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 320 AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLR 399
Cdd:cd17343 328 FLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITVVILFLLR 407
|
..
gi 194391024 400 NI 401
Cdd:cd17343 408 NI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
2-381 |
2.05e-150 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 431.03 E-value: 2.05e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 2 FGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWS 81
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 82 STVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP-ILATILAQSYSWRSTLALSGALC 160
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 161 VVVSFLCLLLIHNEPADVGLRNLDPMPSEG--------KKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 232
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEpdgdaekkEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 233 FFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDspK 312
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAAN--P 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194391024 313 LWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAF 381
Cdd:TIGR00881 311 LMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
1-399 |
6.86e-121 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 355.43 E-value: 6.86e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd17312 8 VFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALC 160
Cdd:cd17312 88 STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 161 VVVSFLCLLLIHNEPadvglrnldpmpsegkkgslkeestlqelllsPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKG 240
Cdd:cd17312 168 LVVAIILFFFLRDSP--------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 241 QSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnYGNPRHGLLLFMMAGMTVSMYLFRVTVtsdSPKLWILVLGA 320
Cdd:cd17312 216 YSLIDAGWFSSLYEVGGIAGTILAGLLSDKL--------FGGRRAPIAVIYMLLMTLSLALFWFFP---HNKLLSIVLLF 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 321 VFGFSSYGPIALFGVIANESAPP-NLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLR 399
Cdd:cd17312 285 LIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
1-397 |
4.07e-75 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 240.38 E-value: 4.07e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:PRK11663 28 MYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALC 160
Cdd:PRK11663 108 SSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 161 VVVSFLCLLLIHNEPADVGL------RNlDPMP----SEGKKGSLKEESTlQELLLSPYLWVLSTGYLVVFGVKTCCTDW 230
Cdd:PRK11663 188 IVVGLFLCWRLRDKPQAMGLpsvgewRH-DALElaqqQEGAGLSRKEILT-KYVLLNPYIWLLSFSYVLVYVVRAAINDW 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 231 GQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnYGNPRHGLLLFMMAGMtvsmyLFRVTVTSDS 310
Cdd:PRK11663 266 GNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKL--------FNGNRGPMNLIFAAGI-----LLSVGSLWLM 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 311 PKLWILVLGAVF---GFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWsTAFWVAEVI 387
Cdd:PRK11663 333 PFASYVMQAACFftiGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHW-TGFFVVISI 411
|
410
....*....|
gi 194391024 388 CAASTAAFFL 397
Cdd:PRK11663 412 AAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
1-398 |
2.46e-69 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 223.05 E-value: 2.46e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALC 160
Cdd:cd17488 88 SSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 161 VVVSFLCLLLIHNEPadvglrnldpmpsegkkgslkeestlqelllsPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKG 240
Cdd:cd17488 168 ILMGIVLCWRLRDRP--------------------------------PYIWLLAFCYVLVYVVRTAINDWGNLYLSETHG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 241 QSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAkaglsnyGNPRHGLLLFMMAGM--TVSMYLFRVTvtsdspKLWIL-V 317
Cdd:cd17488 216 YSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK-------GNRGPMNLIFALGLLvsVGALWLVPVH------SYWLLaT 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 318 LGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWStAFWVAEVICAASTAAFFL 397
Cdd:cd17488 283 CFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWS-GFFIVISIAAAISGLLLL 361
|
.
gi 194391024 398 L 398
Cdd:cd17488 362 P 362
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
2-399 |
1.41e-63 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 209.79 E-value: 1.41e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 2 FGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFA-- 79
Cdd:cd17345 9 FIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGfv 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 80 --WSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ---SYSWRSTLA 154
Cdd:cd17345 89 psATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAifgDGWWRGAFI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 155 LSGALCVVVSFLCLLLIHNEPADVGLRNLDPM----PSEGKKGSLKEESTLQELLL-----SPYLWVLSTG----YLVVF 221
Cdd:cd17345 169 FPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYkgdyPEEADGEEEEQELSAWEIFVkyvlkNKLLWYIAIAnvfvYLVRY 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 222 GVktccTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnYGNPRHGLLLFMMAGMTVSMyl 301
Cdd:cd17345 249 GI----LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL--------FKGRRAPTGIIFMILVIVAL-- 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 302 frVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG-FLAGLPFSTIAKHYSWSTA 380
Cdd:cd17345 315 --IVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIVDHFGWNGG 392
|
410
....*....|....*....
gi 194391024 381 FWVAEVICAASTAAFFLLR 399
Cdd:cd17345 393 FIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-399 |
3.91e-55 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 186.23 E-value: 3.91e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:COG2271 15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALC 160
Cdd:COG2271 95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 161 VVVSFLclllihnepadvglrnldpmpsegkkgslkeestlqelllspYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKG 240
Cdd:COG2271 175 LLLALL------------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 241 QSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTVSMYLFRVTvtsdSPKLWILVLGA 320
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALALLLLALL----PSPALAIALLF 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194391024 321 VFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLR 399
Cdd:COG2271 280 LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
1-383 |
8.90e-46 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 163.48 E-value: 8.90e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEiPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFA- 79
Cdd:TIGR00712 32 IFFGYAAYYLVRKNFALAMPYLVEQ-GFSKGELGFALSAISIAYGFSKFIMGSVSDRSNPRVFLPAGLILSAAVMLLMGf 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 80 --W-SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATI-LAQSYSWRSTLAL 155
Cdd:TIGR00712 111 vpWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWNCAHNIGGGIPPLLVLLgMAWFNDWHAALYF 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 156 SGALCVVVSFLCLLLIHNEPADVGLRNLDP----MPSEGKKGSLKEEST----LQELLLSPYLWVLSTGYLVVFGVKTCC 227
Cdd:TIGR00712 191 PAICAIIVALFAFAMMRDTPQSCGLPPIEEyrndYPDDYNEKAEQELTAkeifMQYVLPNKLLWYIAIANVFVYLLRYGV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 228 TDWGQFFLIQEKGqSALVGSSYMSAL-EVGGLVGSIAAGYLSDRAM-AKAGLSNYgnprhglllFMMAGMTVSMYLFRVT 305
Cdd:TIGR00712 271 LDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIPGTLLCGWMSDKVFkGNRGATGV---------FFMTLVTIAVIVYWMN 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194391024 306 VTSDSpkLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFL-AGLPFSTIAKHYSWSTAFWV 383
Cdd:TIGR00712 341 PAGNP--LVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMV 417
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-399 |
1.88e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 137.32 E-value: 1.88e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 14 TFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFL 93
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 94 NGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHN 173
Cdd:COG2223 103 LGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 174 EPADvglrnldpmPSEGKKGSLKeesTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSAL 253
Cdd:COG2223 183 PPAG---------AAAAAKASLR---DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 254 EVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFrvTVTSDSPKLWILVLGAVFGFSSYGPIALF 333
Cdd:COG2223 251 ALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194391024 334 GVIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVICAASTAAFFLLR 399
Cdd:COG2223 318 ALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
1-398 |
4.72e-35 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 134.45 E-value: 4.72e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEiPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:PRK11273 34 IFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 ----SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGL-GPILATILAQSYSWRSTLAL 155
Cdd:PRK11273 113 vpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLpPLLFLLGMAWFNDWHAALYM 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 156 SGALCVVVSFLCLLLIHNEPADVGL------RNLDPmpsEGKKGSLKEESTLQEL-----LLSPYLWVLSTGYLVVFGVK 224
Cdd:PRK11273 193 PAFAAILVALFAFAMMRDTPQSCGLppieeyKNDYP---DDYNEKHEQELTAKQIfmqyvLPNKLLWYIAIANVFVYLLR 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 225 TCCTDWGQFFLiQEKGQSALVGSSYMSAL-EVGGLVGSIAAGYLSDRAMAkaglsnyGNpRHGLLLFMMAGMTVSMYLFR 303
Cdd:PRK11273 270 YGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIPGTLLCGWMSDKVFR-------GN-RGATGVFFMTLVTIATIVYW 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 304 VTvTSDSPKLWILVLGAVfGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGlpfSTI----AKHYSWST 379
Cdd:PRK11273 341 LN-PAGNPTVDMACMIVI-GFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA---SAIvgytVDFFGWDG 415
|
410
....*....|....*....
gi 194391024 380 AFWVaeVICAASTAAFFLL 398
Cdd:PRK11273 416 GFMV--MIGGSILAVILLI 432
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-364 |
4.78e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 121.37 E-value: 4.78e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPS-LVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFA 79
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 80 WSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGAL 159
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 160 CVVVSFLCLLLIHNEPADVglrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTdwGQFFLIQEK 239
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKR--------PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 240 GQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSnygnprhgLLLFMMAGMTVSMYLFRVTVTSdspkLWILVLG 319
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--------LALLLLILAALGLLLLSLTLSS----LWLLLAL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 194391024 320 AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 364
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
1-398 |
8.48e-31 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 121.14 E-value: 8.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd17319 8 LFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALC 160
Cdd:cd17319 88 ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 161 VVVSFLCLLLIhnePADVGLrnldpmpsegkkgslkeesTLQELLLSPYLWVLSTgylvvfgvktcctdWGQFFLIQEKG 240
Cdd:cd17319 168 LLLAVLWWFYL---RQVWGL-------------------ALGYFGINYALYGLLT--------------WLPTYLKQARG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 241 QSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAglsnygnpRHGLLLFMMAGMTVSMYLFrvtVTSDSPKLWILVLGA 320
Cdd:cd17319 212 FSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA--------RRLVIIIGLLLAAVGLLLA---YLTTSPVVAVILLSL 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194391024 321 VFGFsSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKH-YSWSTAFWVAEVICAASTAAFFLL 398
Cdd:cd17319 281 AGFG-IGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-364 |
2.09e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 119.69 E-value: 2.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALC 160
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 161 VVVSFLCLLLihnepadvglrnldpMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKG 240
Cdd:COG2814 175 LLALLLLLRL---------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 241 QSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFRVTVTSdspkLWILVLGA 320
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLLLLALAGSL----WLLLLALF 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 194391024 321 VFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 364
Cdd:COG2814 305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-397 |
8.34e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 115.99 E-value: 8.34e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ--SYSWRSTLALSGA 158
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 159 LCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGslkeestLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQE 238
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 239 KGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnyGNPRHGLLLFMMAGMTVSMYLFRVTvtsdSPKLWILVL 318
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----------LIGRKPLLLIGLLLMALGLALLLLA----PSLLLLLLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194391024 319 GAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFL 397
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
20-395 |
1.61e-25 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 106.55 E-value: 1.61e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 20 PSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQG 99
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 100 LGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAdvg 179
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 180 lrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLV 259
Cdd:cd17475 177 -------ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 260 GSIAAGYLSDRamakaglsNYGNPRHGLLLFMMAgmTVSMYLFRVTVTSDSPKLWILVLG-AVFGFSSYGPIALFGVIAN 338
Cdd:cd17475 250 GRIGLGRVSDR--------VFGGRRRPVLVITAA--IAAAALLVLSLLSPGTPLWLLVLLlILLGLFAIGWNGLYLTLVA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 194391024 339 ESAPPNLCGTSHAIVGLMANVGGFLAGLPF-STIAKHYSWSTAFWVAEVICAASTAAF 395
Cdd:cd17475 320 ESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
4-398 |
3.31e-25 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 106.27 E-value: 3.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 4 GYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSST 83
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 84 VPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVV 163
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 164 SFLCLLLIHNEPADVGL--RNLDPMPS-------EGKKGSLKEESTLQELLLSPYLWVLstgYLVVFGVKTCCTDWGQFF 234
Cdd:TIGR00893 162 GVLWLKFIPDPPQKAKWltEEEKYIVVggllaeqQGKGPSTPKKYQIKELLKDRRVWGL---ALGQFLVNIGLGFFLTWF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 235 ---LIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKaglsnyGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSP 311
Cdd:TIGR00893 239 ptyLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRR------GKSLVFARKTAIIAGLVLSLLMFATNYVNIP 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 312 KLwILVLGAVFGFSSYGPIALFGVIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTI-AKHYSWSTAFWVAEVICAA 390
Cdd:TIGR00893 313 YA-ALALVALGFFGLGAGAIGWALIS-DNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIaATTGSFAGALMVVAALALI 390
|
....*...
gi 194391024 391 STAAFFLL 398
Cdd:TIGR00893 391 GALSYLLL 398
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-399 |
1.41e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 101.11 E-value: 1.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 97
Cdd:cd17325 18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPad 177
Cdd:cd17325 98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 vglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGG 257
Cdd:cd17325 176 -------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 258 LVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFRVtvtsdSPKLWILVLGAVF---GFSSYGPiALFG 334
Cdd:cd17325 249 ALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALLLLPL-----ATSFWLLLLLLALlglGLGLVFP-ATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194391024 335 VIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLR 399
Cdd:cd17325 312 LLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
2-403 |
2.03e-20 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 92.80 E-value: 2.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 2 FGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFF--- 78
Cdd:PRK09556 35 FIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFgas 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 79 --AWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLAL- 155
Cdd:PRK09556 115 lgSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHVIGMf 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 156 --SGALCVVVSFLCLLLIHNEPADVGLRN--------LDPMPSEGKKGSL-KEESTLQELLLSPYLWVLSTGYLVVFGVK 224
Cdd:PRK09556 195 ifPSIIALIIGFIGLRYGSDSPEELGWGKaeeifgepISEEDKETESTDMtKWQIFVEYVLKNPVIWLLCFANIFLYIVR 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 225 TCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMYLFRV 304
Cdd:PRK09556 275 IGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA----------NGRRALVACIALALIIFTLGVYQ 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 305 TVTSDspklwILVLGAVF--GFSSYGPIALFGVIANESAPPN--------------LCGTSHAIVGLMANVGGFLAGLPF 368
Cdd:PRK09556 345 HATSE-----YMYLASLFalGFLVFGPQLLIGVAAVGFVPKKaigvangikgtfayLFGDSFAKVGLGMIADPTKNGTPI 419
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 194391024 369 STIAKHySWS---TAFWVAEVICAASTA--AFFLLRNIRT 403
Cdd:PRK09556 420 FGYTLT-GWAgtfAALDIAAIGCICLMAivAVMEERKIRR 458
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-396 |
3.16e-19 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 88.48 E-value: 3.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 12 RKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALW 91
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 92 FLNGLAQ--GLGWPPCGKVLRKWFEPSQfGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLL 169
Cdd:cd17355 99 GLLGGGGagTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 170 LIHNEPADVGLRNLDPMPSEGkkgslkEESTLQELLLSPYLWVLSTGYLVVfGVKTCCTDWGQFFLIQEKGQSALVGSSY 249
Cdd:cd17355 178 LLRRRPADLALRAYDDASPAS------PGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 250 MSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTVSMYLFrvtvtSDSPKLWILVLGAVFGFSSYGP 329
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDR---------YSPRRLLAASYALRALGLALLLL-----LPFPPLALLLFAALFGLGWGAT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194391024 330 IALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVICAASTAAFF 396
Cdd:cd17355 317 VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
18-396 |
6.13e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 84.53 E-value: 6.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 97
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLGWPPCGKVLRKwFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHnepad 177
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 vglRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTdwgqfFLIQEKGQSALVGSSYMSALEVGG 257
Cdd:cd17478 172 ---LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 258 LVGSIAAGYLSDRAMAKAglsnygnprhgLLLFMMAGMTVSMYLFRVTvtsdsPKLWILVLGAVFGFSSYGPIALFGVIA 337
Cdd:cd17478 244 AIGTLIGGPLSDRFGRRR-----------VIIASLLLAAPFLLLFLLT-----PGIWSYILLVLAGFLLFASFPVTVVLA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 194391024 338 NESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFF 396
Cdd:cd17478 308 QELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
18-398 |
9.76e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.15 E-value: 9.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 97
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLGWPPCGKVLRKWFePSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAD 177
Cdd:COG2807 120 IAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 vglrnldpmpsegkKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQEKGQSALVGSSYMSALEVGG 257
Cdd:COG2807 199 --------------AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 258 LVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMYLFrVTVTSDSPKLWILVLGAVFGFSsygPIALFGVIA 337
Cdd:COG2807 264 IPGSLLVPLLADRL----------GDRRPLLLLLGLLGLAGLLGL-LLAPGSLPWLWAVLLGLGQGGL---FPLALTLIG 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194391024 338 NESAPPN----LCGTSHAIVGLMANVGGFLAGLPFSTIAkhySWSTAFWVAEVICAASTAAFFLL 398
Cdd:COG2807 330 LRARTPAeaaaLSGMAQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-396 |
5.99e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.66 E-value: 5.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 34 GFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWF 113
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 114 EPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAdvglrnldpmpseGKKG 193
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP-------------KKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 194 SLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMA 273
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 274 KAglsnygnprhglLLFMMAGMTVSMYLFrvTVTSDSPKLWILVLgAVFGFSSYGPIALFGVIANESAPPNLcGTSHAIV 353
Cdd:cd17324 264 RA------------LLIALLLLAAALLLL--TLLGPSPLLLLVGL-VLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLY 327
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 194391024 354 GLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFF 396
Cdd:cd17324 328 LAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
16-366 |
2.26e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 74.32 E-value: 2.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 16 SFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNG 95
Cdd:TIGR00895 37 GFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 96 LAQGLGWPPCgKVLRKWFEPSQF-GTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGA-----LCVVVSFL--- 166
Cdd:TIGR00895 117 LGLGGLMPNL-NALVSEYAPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaplllLLLLMRFLpes 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 167 ----------CLLLIHNEPADVGLRNLDPMPSE------GKKGSLKEESTLQELLLSPYLWVL-STGYLVVFGVktccTD 229
Cdd:TIGR00895 196 idflvskrpeTVRRIVNAIAPQMQAEAQSALPEqkstqgTKRSVFKALFQGKTARITVLLWLLyFMLLVGVYFL----TN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 230 WGQfFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMYLFRVTvtsd 309
Cdd:TIGR00895 272 WLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGAVFAVLVGSTLF---- 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 194391024 310 SPKLwILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL 366
Cdd:TIGR00895 337 SPTL-LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIGRLGAII 389
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-398 |
1.02e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.83 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 97
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAqSYSWRSTLALSGALCVVvSFLCLLLIHNEPad 177
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPV-AFLAILFLLPEP-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 vglrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGG 257
Cdd:cd17474 177 ---------KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 258 LVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMYLFRVTvtsdsPKLWILVLG-AVFGFSSYGPIALFGVI 336
Cdd:cd17474 248 ALGSLFVGRLLKKR----------FGARRILVIGLLLYALSLLLLGFV-----PSLALLLIAiVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194391024 337 ANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLL 398
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
1-396 |
6.21e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.96 E-value: 6.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS-YSWRSTLALSGAL 159
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 160 CVVVSFLCLLLIHNEPadvgLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLI--- 236
Cdd:cd17328 164 GVLLAILLLLFVREPP----RGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRafg 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 237 QEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKaglsnygNPRHGLLL--FMMAGMTVSMYLFRVTVTSDSPKLW 314
Cdd:cd17328 240 VGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK-------TPRADPLVcaVGLLAAAPFLFLALVLALSNLLLAW 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 315 ILV-LGAVFGFSSYGPIAlfgVIANESAPPNLCGTSHAIVGLMAN-----VGGFLAGLPFSTIAKHY--------SWSTA 380
Cdd:cd17328 313 VLLfLGEFLLSLNWAPVF---AILLYVVIPTRRSTASAIQILLSHllgdaGSPYLIGLISDLLRQNKdsplaeaaSLQYA 389
|
410
....*....|....*.
gi 194391024 381 FWVAEVICAASTAAFF 396
Cdd:cd17328 390 LLLCSFVLVLGGFFFL 405
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-404 |
1.19e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.73 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 97
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLGWPPCGKVLRkWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ---SYSWRSTLALSGALCVVVSFLCLLLIHne 174
Cdd:COG0738 110 LGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKL-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 175 padvglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALE 254
Cdd:COG0738 187 ----------PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 255 VGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFRVTvtsdsPKLWILVLGAV---FGFSSYGPIA 331
Cdd:COG0738 257 GGMTIGRFLGGFLLKRF-----------GPVRLLRLSALLAAVGLLLALLA-----PGPWLALIGLAlvgLGLSLMFPTI 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194391024 332 LfgVIANESAPPNLCGTShAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTK 404
Cdd:COG0738 321 F--SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-398 |
2.91e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 67.64 E-value: 2.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 15 FSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWL-----FSSGLLLVGLVNIFFAWSSTVPVFAA 89
Cdd:cd06173 18 FTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 90 LWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSgALCVVVSFLCLL 169
Cdd:cd06173 98 LAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN-ALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 170 LIHNEPADVGLRNLDPMPSEGKKGslkeestLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSY 249
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREG-------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 250 MSALEVGGLVGSIAAGYLSDRamakaglsnygNPRHGLLLFMMAGMTVSMYLFRVtvtsdSPKLWILVLGAVFGFSSYGP 329
Cdd:cd06173 250 LAAFGVGALLGALLLGRLSKR-----------RRRGRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 330 I-ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLL 398
Cdd:cd06173 314 FnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
1-396 |
7.43e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.09 E-value: 7.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIP--LDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFF 78
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 79 AWSSTVPVFAALWFLNGLAQGlGWPPCGKVLRKWFEPSQF-GTWWAILSTSMN----LAGGLGPILATILAQSYSWRSTL 153
Cdd:cd17316 84 GLLPTPILLLVLRFLQGIGIG-GEYPGASTYVAEFAPSKRrGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRILF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 154 ALSGALCVVVsflclllihnepadvglrnldpmpsegkkgslkeestlqeLLLSPYLWVLSTGYLVVFGVKTCCTDWGQF 233
Cdd:cd17316 163 LIGALPALLA----------------------------------------LLLRRRTLLLILLWFFISFGYYGLTTFLPT 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 234 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFrvTVTSDSPKL 313
Cdd:cd17316 203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSGILALPL--FYLLSGSPT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 314 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMAN-VGGFLAGLPFSTIAKHYSWSTAFWVAEVICAAST 392
Cdd:cd17316 270 LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRlGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
....
gi 194391024 393 AAFF 396
Cdd:cd17316 350 IVAL 353
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
2-397 |
7.21e-11 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 63.49 E-value: 7.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 2 FGGYSLYYFNRKTFSFVMPSLVEEI-------------------PL--DKDD----LGFITSSQSAAYAISKFVSGVLSD 56
Cdd:cd17342 9 FFSYALLHATRKTFSNVKPSISAEWtpsnsntsielheetwnanPLfpSQDDaalfLGVLDTIFLFSYAIGLFISGWLGD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 57 QMSARWLFSSGLLLVGLVNIFFAWSS------TVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSmn 130
Cdd:cd17342 89 RLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLWSAC-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 131 laGGLGPILATILAQsyswrSTLALSGALCVVVSFLCLLLIhnepADVGLRNLDPMPSEGKKGSLKeestlqelllspYL 210
Cdd:cd17342 167 --ASVGNIIGALLAS-----SVLDYGYEYAFLVTSSLLFAG----AIVVFFGLLSSPPGVIPYSLA------------YA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 211 WVLSTGYLVVFgvktcctdWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRaMAKaglsnygnpRHGLLLF 290
Cdd:cd17342 224 CLKLVNYSFFF--------WLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDR-MGS---------RSPVVVV 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 291 MMAGMTVSMYLFRvtvTSDSPKLWILVLGAVFGFSSYGPIALF--GVIANESAPPNLCGTSHAivglMANVGGFLAG--- 365
Cdd:cd17342 286 MLLLAIPSLFVYS---HSPSDKVLNAFVMTITGFFIGGPANLIssAISADLGRQPQLRGSSEA----LATVTGIIDGtgs 358
|
410 420 430
....*....|....*....|....*....|....*....
gi 194391024 366 -------LPFSTIAKHYSWSTAFWVAeVICAASTAAFFL 397
Cdd:cd17342 359 igaaigqVLVPLIQNRLGWMWVFYFF-IIMTILTIVCIL 396
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
15-181 |
8.44e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.52 E-value: 8.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 15 FSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLN 94
Cdd:COG0477 33 VNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 95 GLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNE 174
Cdd:COG0477 113 GIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESR 192
|
....*..
gi 194391024 175 PADVGLR 181
Cdd:COG0477 193 GLLLALL 199
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
19-389 |
4.72e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.80 E-value: 4.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 19 MPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQ 98
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 99 GLGwPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILAT-ILAQSYSWRSTLALSGALCVVVsFLCLLLIHNEPad 177
Cdd:cd17333 99 GIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLL-AILILLTLFPE-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 vglrnlDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGG 257
Cdd:cd17333 175 ------LPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 258 LVGSIAAGYLSDRAMAKAglsnygnprhglllFMMAGMTVSMYLFRVTVTSDSPkLWILVLGAVFGFSSYGPIALFGVIA 337
Cdd:cd17333 249 TIGRLLGGPISRRIKPHT--------------LLVLSGSGALLGLLILLLAPTL-VVGLVATALLGLFMAALFPTILSLG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 194391024 338 NESAP-PNLCGTSHAIVglMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICA 389
Cdd:cd17333 314 ISNLPyAKGKGTSVLLA--AGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYA 364
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
2-398 |
6.36e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 60.39 E-value: 6.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 2 FGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWS 81
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 82 STVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ----SYSWRSTLALSG 157
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLFLLGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 158 ALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGSLKEESTLQELLLSPylwVLSTG-YLVVFGVKTcctdWGQFFLI 236
Cdd:cd17371 165 LPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLAS---LLATGaLGGYYGITT----WLPSYLT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 237 QEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTVSMYLFrvtvTSDSPKLwIL 316
Cdd:cd17371 238 GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLYFF----LPLSPTL-IL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 317 VLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL-PFST--IAKHYSWSTAF-WVAEVICAAST 392
Cdd:cd17371 304 ILGFPLGFFASGPFSGMGAYLTELFPTAVRATA---QGFCYNVGRIIGALfPFLVgfLATSGSLGTAIaVFAAVYYIAGL 380
|
....*.
gi 194391024 393 AAFFLL 398
Cdd:cd17371 381 VLALLL 386
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
15-397 |
6.59e-10 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 60.34 E-value: 6.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 15 FSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVP-VFAALWFL 93
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYwGLLVLGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 94 NGLAqGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS-------YSWRSTLALSGALCVVVSFL 166
Cdd:cd17341 98 LGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAivfdggfVGWRNAFFVPGILLAIAAVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 167 CLLLIHNEPadvglrnldpmpsEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVG 246
Cdd:cd17341 177 VLLFGDDLP-------------TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 247 SSYMSALEVGGLVGSIAAGYLSDRAMAKaglsnygnprhGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSS 326
Cdd:cd17341 244 GILAALFPLAGALARPAGGWLSDRFGGR-----------RRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194391024 327 YGPI--ALFGVIANESapPNLCGTSHAIVGLMANVGGFLAGLPFSTIAK-HYSWSTAFWVAEVICAASTAAFFL 397
Cdd:cd17341 313 AGAGngSVFRMVPFIF--RRELGAVTGLVGAIGGLGGFFLPLLFGSSALmTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
27-399 |
9.48e-10 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 60.02 E-value: 9.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 27 PLDKDD----LGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWS-----STVPVFAALWFLNGLA 97
Cdd:cd17344 54 PFDGKNgtelLGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGyywniHSLWYFVVVQILAGLF 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAqSYSWRSTLALSGALCVVVSFLCLLLIHNEPAD 177
Cdd:cd17344 134 QSTGWPSVVACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFV-SSAWGLSFIVPGIIIAAMGVLVFLFLVEHPPG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 VglrnldpmpsegkkgslkeestlqelllSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQEKGQSALVGSSYMSALEVGG 257
Cdd:cd17344 213 V----------------------------IEFSLCLFFAKLVSYTFLY----WLPLYISNTAILSAKKAGDLSTLFDVGG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 258 LVGSIAAGYLSDRAMAKAGLSnygnprhGLLLFMMAGMtvsMYLFRvTVTSDSPKLWILVLgAVFGFSSYGPIALF--GV 335
Cdd:cd17344 261 IVGGILAGYISDYTGGRATTC-------AAMLILAAPM---LFIYN-YFGQVSMTTNIVLL-IVCGLLVNGPYALIttAV 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194391024 336 IANESAPPNLCGTSHAI------------VGlmANVGGFLAGLPFStiakhYSWSTAFWVaeVICAASTAAFFLLR 399
Cdd:cd17344 329 SADLGTHKSLKGNARALatvtaiidgtgsIG--AALGPLLAGLISS-----RGWNNVFYM--LIAADVCAGLLLTR 395
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-170 |
3.47e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.01 E-value: 3.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 10 FNRKTFSFVMPS----LVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVP 85
Cdd:cd17329 10 LNRLGFFMVWPFmaiyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 86 VFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSwrSTLALSGALCVVVSF 165
Cdd:cd17329 90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLAAAVLFLLAA 167
|
....*
gi 194391024 166 LCLLL 170
Cdd:cd17329 168 LVLLF 172
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
16-399 |
1.08e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 56.44 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 16 SFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNG 95
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 96 LAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALsGALCVVVSFLCLLlihnep 175
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL-GGVPPLILLPLLR------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 176 advglrnldpmpsegkkGSLKeestlqelllspyLWVLS-TGYLVVFGVKTcctdWGQfFLIQEKGQSALVGSSYMSALE 254
Cdd:cd17365 172 -----------------GTLL-------------LWVTFfMGLLLVYLLNS----WLP-KLMVEAGYSLSQALTITLLLN 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 255 VGGLVGSIAAGYLSDRamakaglsnyGNPRHGLLLFMMAGMtVSMYLFrvtVTSDSPKLWILVLGAVFGFSSYGPIALFG 334
Cdd:cd17365 217 IGGVIGSLLLGWLADR----------FGPKRVLALFFALGA-VSLALL---GVSPASLVLLYVLVFLAGACVNGAQVGLY 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194391024 335 VIANESAPPNLCGT----SHAIVGLMANVGGFLAGLpfsTIAKHYSWSTAFWVAEVICAASTAAFFLLR 399
Cdd:cd17365 283 ALAARFYPTEVRATgvgwALGVGRLGAILGPLLGGL---LLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-399 |
1.26e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.41 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 19 MPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQ 98
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 99 GLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVsflclllihnepadv 178
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA--------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 179 glrnldpmpsegkkgslkeestlqeLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGL 258
Cdd:cd17321 164 -------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAML 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 259 VGSIAAGYLSDRAMAKAglsnygnprhgLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLgAVFGFSSYGPIALFGVIAN 338
Cdd:cd17321 219 VAAPLAGRLADRFGPRL-----------VLVAGLLLTAVGLLLLALLGADSSVWLLLPGL-VLLGLGLGLFATPLTNAAL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 339 ESAPPNLCGTSHAIVGLMANVGGFL-----------------------AGLPFSTIAKHYSWSTAFWVAEVICAASTAAF 395
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLGGALgvallgalltaglsanlgdsgvaALLSAAAAAFAAGFHLAFLVAAALALLAALLA 366
|
....
gi 194391024 396 FLLR 399
Cdd:cd17321 367 LLLP 370
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
14-398 |
1.99e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 55.69 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 14 TFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWS-STVPVFAALWF 92
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAiSLPLLFLGYGV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 93 LNGLAQGLGWPPCGKVLRKWFePSQFGtwwaiLSTSMNLAG-GLGPI----LATILAQSYSWRSTLALSGALCVVVSFLC 167
Cdd:cd17353 101 LGGIGAGIGYITPVSTAVKWF-PDKRG-----LATGIVIAGfGLGSLifspLIAYLINTVGVPTTFLILGIIFLIIIVIG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 168 LLLIHNEPADVGlrNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLstgYLVVFgvktCCTDWGQF-------FLIQEKG 240
Cdd:cd17353 175 AFLIRDPPKGWV--PPGVDPLANNAENSPRDYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakpIGQEFAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 241 QSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLLFMMAGMTVSMYLFrvtVTSDSPKLWILVLGA 320
Cdd:cd17353 246 LDAGIAALAVSILSIFNGGGRPFWGWLSDK---------IG--RKNTLSIAFLIQGVAMFLL---PFIGSVAVLFVLGVA 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194391024 321 VFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAevICAASTAAFFLL 398
Cdd:cd17353 312 LIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIA--AALSLVALALAL 387
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-399 |
2.42e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 97
Cdd:cd17489 18 VLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRStLALSGALCVVVSFLCLLLIHNEPAd 177
Cdd:cd17489 98 WGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV-LFIVAAVLALLALLLVFLVKDPPP- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 vglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTG--------YLVVFGVKTCCTDWGQFFLIQekgQSALVGSSY 249
Cdd:cd17489 176 -------VAAEEAEAGTRAFRRLVEKKVLPPALILFLASiaygaistFLPLYAAERGISNAGLFFTVY---AIALLLSRP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 250 MSalevgglvgsiaaGYLSDramakaglsnygnpRHGLLLFMMAGMTVsmYLFRVTVTSDSPKLWILVLGAVF---GFSS 326
Cdd:cd17489 246 FS-------------GKLSD--------------RKGPKTVIIPGLLL--LALGLLLLSFAGSPWMLLLAAVLyglGFGL 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194391024 327 YGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLR 399
Cdd:cd17489 297 LFPA--LQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
29-171 |
2.18e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 52.62 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 29 DKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIF---FAWSSTVPVFAaLWFLNGLAQGLGWPPC 105
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtplAARGGYGALIV-LRILQGLAQGVTFPAM 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 106 GKVLRKWFEPSQFGTwwaiLSTSMNLAGGLGPI----LATILAQSYSWRSTLALSGALCVVVSFLCLLLI 171
Cdd:cd17318 133 HALWAKWAPPLERSR----LTSIAYSGSQFGTViampLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
42-365 |
7.46e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 50.65 E-value: 7.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 42 AAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTW 121
Cdd:cd17320 45 LGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 122 WAILSTSMNLAGGLGPILATILAQSYSWRS---TLALSGALCVVVSFLCLllihnepadvglrnldPMPSEGKKGSLKEE 198
Cdd:cd17320 125 FSLLMMILAIAPALAPLLGGLLLLFFGWRAifvFLALLGLLLLLLVLLFL----------------PETLPEEKRKPLLS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 199 STLQ---ELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKA 275
Cdd:cd17320 189 SLLRaykRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 276 GLsnygnpRHGLLLFMMAGMTVSmyLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIaneSAPPNLCGTSHAIVGL 355
Cdd:cd17320 269 LL------RLGLLLLLAAALVLL--LAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL---EPFPHVAGTASALLGF 337
|
330
....*....|
gi 194391024 356 MANVGGFLAG 365
Cdd:cd17320 338 LQFLIGALAG 347
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-399 |
9.34e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 50.63 E-value: 9.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 13 KTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVF-AALW 91
Cdd:cd17352 20 NSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 92 FLNGLAQGLGWPPCGKVLRKWFEPsqfgtwWAILSTSMNLAG-GLG----PILATILAQSYSWRSTLALSGALCVVVSFL 166
Cdd:cd17352 100 VLGGLGLGLIYSPAIVIVGQYFEK------KRGLATGIAVAGsGVGtfvfPPLLRYLLDNYGWRGALLILGGLCLNLCVC 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 167 CLLLIhnepadvglrnldpmpsegkkgslkeestlqeLLLSP-YLWVLSTGYLVVFGVKTCCTdwGQFFLIQEKGQSALV 245
Cdd:cd17352 174 GLLLR--------------------------------LLKDPtFVLLALGVSFAMLGFFVPFV--YLPSYAKSLGIDESD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 246 GSSYMSALEVGGLVGSIAAGYLSDRamakaglsnygnPRHGLLLFMMAGMTVS-MYLFRVTVTSDSPKLWilVLGAVFGF 324
Cdd:cd17352 220 AAFLLSIIGISDIVGRILLGLLADK------------PRIGRLYLYIFTLLILgLSLLAFPLATTYVGLI--VFSVLFGF 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194391024 325 SSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGfLAGLPFS--TIAKHYSWSTAFWVAEVICAASTAAFFLLR 399
Cdd:cd17352 286 CSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAA-LVGPPIAglLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
1-162 |
1.24e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 50.25 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 --SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGA 158
Cdd:cd17380 84 laYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
....
gi 194391024 159 LCVV 162
Cdd:cd17380 164 LGLL 167
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
42-172 |
2.09e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.87 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 42 AAYAISKFV----SGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQ 117
Cdd:TIGR00880 5 AGYALGQLIysplSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 194391024 118 FGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIH 172
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
5-365 |
4.91e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 48.40 E-value: 4.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 5 YSLYYFNRKTFS--FVMpSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSS 82
Cdd:cd17327 14 YFLQYLDKSNISnaAVM-GMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 83 TVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS------YSWRSTLALS 156
Cdd:cd17327 93 NFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAGWRWLFIIE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 157 GALCVVVSFLCLLLIHNEPADVGLRN-------LDPMPSEGKKGSLKEE--STLQELLLSPYLWVLStgyLVVFGVKTCC 227
Cdd:cd17327 173 GLITIIIGLVIFFWLPDNPSKAWFLTeeekelaVERLRANQTGKGDQKFkwKQIKEAFKDPRTWLLF---LFFFCSQITN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 228 TDWGQF-FLIQEKGQSALVGSSYMS-ALEVGGLVGSIAAGYLSDRAmakaglsnygnprHGLLLFMMAGMTVSMYLFRVT 305
Cdd:cd17327 250 NGISNFlPLILKSLGFYSLQTNLLSvPIGALGAVSLLIAALLSDRF-------------KKRGLFAIFACVLALVGSIIL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194391024 306 VTSDSPklWILVLGAVF--GFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAG 365
Cdd:cd17327 317 LAAPNP--PGAYFAAYIlgGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
33-396 |
1.43e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 33 LGFITSSQSAAYAISKFVSGVLSDQMSARWLF-SSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPP------- 104
Cdd:cd17370 36 VGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPrdallad 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 105 -CGKVLRKWfepsQFGtwwaiLSTSMNLAGG-LGPILATIL--AQSYSWRSTLALSgALCVVVSFLCLLLIHNEPadvgl 180
Cdd:cd17370 116 aTPPSGRGK----AFG-----LHRALDTLGAvLGPLLAALLlyLLGGNYRTIFLLA-AIPALLALLILLFVVKEY----- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 181 rnldpmpsEGKKGSLKEESTLQELLLSPYLWVlstgYLVVFGVKTCCTDWGQFFLI--QEKGQSALVGSSYMSALEVGGL 258
Cdd:cd17370 181 --------PRPPKLRKKSKKTSLKKLPKAFWL----YLLAVALFALGNFSFAFLILraQELGLSAALIPLLYALFNLVYA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 259 VGSIAAGYLSDRamakaglsnygNPRHGLLLFmmagmTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPI-ALFGVIA 337
Cdd:cd17370 249 LAAYPAGRLSDR-----------IGRKKLLIL-----GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAV 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194391024 338 NESAPPNLCGTS----HAIVGLMANVGGFLAGLpfstIAKHYSWSTAFWVAEVICAASTAAFF 396
Cdd:cd17370 313 ADLVPAELRGTAyglfNTVVGIGWLLASLIAGY----LWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
16-159 |
1.54e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.80 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 16 SFVMPSLVEEI-PLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW---SSTVPVFAALW 91
Cdd:cd17503 198 MFLLPLYLQNVlGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpDTSLWLIILPL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194391024 92 FLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGAL 159
Cdd:cd17503 278 FIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELL 345
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
45-413 |
4.32e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 4.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 45 AISKFVSGVLSDQMSARW-------LFSSGLLLVGLVNIFFA--WSSTVPV--FAALWFLNGLAQGLGWPPCGKVLRKWF 113
Cdd:COG2211 60 AITDPLIGALSDRTRTRWgrrrpwiLIGAIPLALSFVLLFTApdLSPTGKLiyALVTYLLLGLAYTLVNIPYSALGAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 114 EPSQ-----FGTWWAILSTSMNLAGGLGPILATILA--QSYSWRSTLALSGALCVVVSFLCLLLIHnepadvglrnlDPM 186
Cdd:COG2211 140 PDYEertrlSSWRFAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFFGTK-----------ERP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 187 PSEGKKGSLKEesTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGY 266
Cdd:COG2211 209 VPEEEKVSLKE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 267 LSDRamakaglsnYGnpRHGLLLFMMAGMTVSMYLFRVTVTSDSPklWILVLGAVFGFSSYGPIALFGVIANESAPPNLC 346
Cdd:COG2211 287 LAKR---------FG--KKKAFIIGLLLAALGLLLLFFLGPGNLW--LLLVLAALAGIGLGAILVLPWAMLADVVDYDEW 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 347 GTSH----------------------AIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTK 404
Cdd:COG2211 354 KTGRrreglyfgiftfaiklgqalagALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRER 433
|
....*....
gi 194391024 405 MGRVSKKAE 413
Cdd:COG2211 434 HAEIRAELA 442
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
31-177 |
4.66e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 45.50 E-value: 4.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 31 DDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVfaALWFLNGLAQGLGWPPC----G 106
Cdd:TIGR00894 76 ALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGI--ALVVFCRVIQGLAQGSVspatH 153
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194391024 107 KVLRKWFEPSQFGTWwailsTSMNLAGGL------GPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAD 177
Cdd:TIGR00894 154 KIIVKWAPPKERSRL-----LGMSTSGFQlgtfifLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSI 225
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
43-328 |
5.32e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.87 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 43 AYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWW 122
Cdd:cd17323 46 GFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAM 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 123 AILSTSMNLAGGLGPILATILAQSYSWRST---LALSGALCVVVSFLCLLLIhnepadvglrnldpmpsegkkgslkees 199
Cdd:cd17323 126 GVYSLGPLLGPALGPIIGGFITQSLGWRWIfwfLAIISGFCLILIFLFLPIV---------------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 200 tlqeLLLSPY-------LWVLSTGYLVVFGVKTCCTDWGqffliqekgqsalVGSSYMSALeVGGLVGSIAAGYLSDRAM 272
Cdd:cd17323 178 ----LLLGLYvglvyaiLYLFLTAFPYVFGEVYGFSPGE-------------VGLMYLPIG-IGALIGSIIGGRLSDYYY 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 273 AKAGLSNYGNPR-HGLLLFMMAG---MTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYG 328
Cdd:cd17323 240 RRLKKKNGGKPEpEARLPPAFIGaflFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLML 299
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
45-399 |
5.70e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 5.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 45 AISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAI 124
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 125 LSTSMNLAGGLGPILATILAqSYSWRSTLALSGalcvvVSFLCLLLihnepADVGLRNLDPMPSEGKKGSLKEESTLQEL 204
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL-----LALPVLIL-----VLLFLPEPARKSKSAASPGAATAAALPWK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 205 LLSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPR 284
Cdd:cd17473 198 RVLPIYFLAFLAMLLFYVIPI----QLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL-----------GK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 285 HGLLLFMMAGMTVSMYLFrvtvtSDSPKLWILVLGAV---FGFSSYGPIALfgVIANESAPPNLCGTSHAIVGLMANVGG 361
Cdd:cd17473 263 RRLLAIGFALMALGFLLL-----ALASGLWVVLLGAIlagLGFGLLLPTLN--SWAMSLVPPELRGRAMGIVTSAFFLGQ 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 194391024 362 FLAGLPFSTIAKHY-SWSTAFWVAEVICAASTAAFFLLR 399
Cdd:cd17473 336 FLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
234-398 |
6.69e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 6.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 234 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFrvtVTSDSPkL 313
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----------GRRRVLLLGLLLFALGSLLC---ALAPSL-W 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 314 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTA 393
Cdd:COG2814 100 LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179
|
....*
gi 194391024 394 AFFLL 398
Cdd:COG2814 180 LLLRL 184
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
19-151 |
1.07e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.10 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 19 MPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLF--SSGLLLVGLVNIFFAWSSTVPVFAALwfLNGL 96
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFltALALFTLGSLLCGLAPNLASLIIFRI--LQGF 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 194391024 97 AQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRS 151
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRW 151
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-395 |
1.24e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 97
Cdd:cd17477 18 LLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILatiLAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAD 177
Cdd:cd17477 98 LAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL---LALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 vglrnldpmpsegkkgsLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQeKGQSALVGSSYMSALEVGG 257
Cdd:cd17477 175 -----------------IEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 258 LVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFRVTVTSDspkLWILVLGAVFGFSSYGPIALFGVIA 337
Cdd:cd17477 237 LLLQWPLGWLADRF-----------DRRRVLLGCALLGALAALLLPLVPGLP---LALLVLLFLWGGAAGPLYTLALALA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 194391024 338 NESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAF 395
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
29-159 |
1.24e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 43.87 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 29 DKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVP--VFAALWFLNGLAQGLGWPPCG 106
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHygCVIFVRILQGLVEGVTYPACH 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 194391024 107 KVLRKWFEPSQfGTWWAILSTSMNLAGG-LGPILATILAQSYSWRSTLALSGAL 159
Cdd:cd17382 127 GIWRKWAPPLE-RSRLATTAFCGSYAGAvVGMPLSGILVQYVGWSSPFYVYGVF 179
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-166 |
1.30e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 14 TFSFVMPSLVEEIPLDkdDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLL--VGLVNIFFAWSSTVPVFAAlw 91
Cdd:cd17489 212 AISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLlaLGLLLLSFAGSPWMLLLAA-- 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194391024 92 FLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLaLSGALCVVVSFL 166
Cdd:cd17489 288 VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF-LLAAVVVLLALV 361
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
1-170 |
1.96e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.28 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFnrkTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd17369 237 RLAENVLFYL---FTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFW 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 ----SSTVPVFAALWFLNGLAQGLGWPPCGKVLrkwfePSQFGTwwAI----LSTSMN----LAGGLGPILATIL-AQSY 147
Cdd:cd17369 314 lldtGSTWLIVLAAVVVLGVLHGMMYGPQAAFL-----AELFPT--RVrytgASLGYQlgaiLGGGFAPLIATALvAATG 386
|
170 180
....*....|....*....|...
gi 194391024 148 SWRSTLALSGALCvVVSFLCLLL 170
Cdd:cd17369 387 SWWPVALYLAALA-VISLVAALF 408
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
240-398 |
3.69e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.54 E-value: 3.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 240 GQSALVGSSYMSALEVGGLVgsiaAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLfrvtvTSDSPKLWILVLG 319
Cdd:cd17324 34 AQAGLLVSAYALGYALGALL----LGPLSDRI-----------ERRRLLLVLLLLFILGNLL-----AALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 320 -AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVgLMANVGGFLAGLPFST-IAKHYSWSTAFWVAEVICAASTAAFFL 397
Cdd:cd17324 94 rALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGlLGQLLGWRAAFLAIAVLALLAALLLWR 172
|
.
gi 194391024 398 L 398
Cdd:cd17324 173 L 173
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
234-413 |
1.09e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 234 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRhgLLLFMMAGMTVSMYLFRVTVTSdspkL 313
Cdd:pfam07690 22 LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRR--VLLIGLLLFALGLLLLLFASSL----W 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 314 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTA 393
Cdd:pfam07690 87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180
....*....|....*....|
gi 194391024 394 AFFLLRNIRTKMGRVSKKAE 413
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
240-398 |
1.14e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.64 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 240 GQSALVGSSYMSALEVgglVGSIAAGYLSDRAMakaglsnygnpRHGLLLFMMAGMTVSMYL---FRVTVTSDSPKLWIL 316
Cdd:cd17315 213 GTASILASIIVGVVNL---LATLVAIRLVDKVG-----------RRPLLLIGFAGMAASLLLlaiAFLLPALAKAAGWLA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 317 VLGA---VFGFS-SYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAAST 392
Cdd:cd17315 279 LLGIllyIAAFAmGAGPV--PWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLAL 356
|
....*.
gi 194391024 393 AAFFLL 398
Cdd:cd17315 357 VFVFFF 362
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
10-179 |
2.61e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.59 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 10 FNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAA 89
Cdd:cd06180 13 IGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 90 LWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILstsmnLAG-GLGPILAT-----ILAQSYSWRSTLALSGALCVVV 163
Cdd:cd06180 93 LRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLL-----FAGvGLGIALSGllvpaGLGGGLSWRAGWLALALLSAVL 167
|
170
....*....|....*.
gi 194391024 164 SFLCLLLIHNEPADVG 179
Cdd:cd06180 168 LLLSFLLLRRGPSAPT 183
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
17-395 |
2.73e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.55 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 17 FVMPSLVEEIP-------LDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAA 89
Cdd:cd17393 13 ILMASWATRIPaikdrlgLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 90 LWFLNGLAQGLG---WPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGpiLATILAQSYSWRSTLALSGALCVVVSFL 166
Cdd:cd17393 93 ALFLFGAANGALdvaMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLG--AAAIGAGVSPGVHLLAAAVLLLLAALVA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 167 CLLLihnePADVGLRNLDPMPSEGKKGSLkeestlqelLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVG 246
Cdd:cd17393 171 IRAL----LPGTGEAAEDRPDGAGKPGFL---------LPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 247 SSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSnygnprhglllfmmAGMTVSMYLFRVTVTSDSPklWILVLGAV---FG 323
Cdd:cd17393 238 ALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLR--------------AGALLAALGLLLALLAPSV--WVALAGFAlmgLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194391024 324 FSSYGPIALFGVIANESAPPNLCGTSHAIVGLmanvGGFLAGLP-FSTIAKHYSWSTAFWVAeVICAASTAAF 395
Cdd:cd17393 302 LSVVVPLAFSAAGALPGLAAGIAVARVATLGY----LGFLVGPPlIGFLADATGLRTAFLVV-ALLALLVALL 369
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
83-391 |
3.20e-03 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 39.59 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 83 TVPVFAALWFLNG--LAQGLGWPPC---GKVLRK-WFEPSQFGTWWAILSTsMNLAGG-----LGPILatilaqsyswrs 151
Cdd:cd17397 89 PVPNHLATWLIHIgqFLNGLAGPVAmaaAPFLSAtWFPPNQRATATAIASI-FNYLGGaasflIGPLV------------ 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 152 TLALSGALCVVVsFLCLLLIhnepadvgLRNLDPMP----SEGKKGSLKeeSTLQELLLSPYLWVLSTGYLVVFGVKTCc 227
Cdd:cd17397 156 LMYLEFGWSALI-FLAMLIY--------FPSKPPTPpsvsASTQRLSYK--SGILSLLKNKRFWLIALAYGIPTGVYAG- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 228 tdWGQFFLIQEKGQ------SALVGssYMSAleVGGLVGSIAAGYLSDRAMAKAGLsnygnprhgLLLFMMAGMTVSMYL 301
Cdd:cd17397 224 --WSGVLDVNLTPFgvsqveAGWIG--FYST--VAGCVGGIIVGRFADRFGGRMKL---------ILLLLFSGATGSFLW 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 302 FRVTVTSDSP--KLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG--FLAGLPFSTIAKhySW 377
Cdd:cd17397 289 FTLICLKLLPfsTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGlvFLLILIIPNIGT--SW 366
|
330
....*....|....
gi 194391024 378 STafWVAEVICAAS 391
Cdd:cd17397 367 MN--WCLLGSCLLS 378
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
18-172 |
3.73e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.10 E-value: 3.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDD---LGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLN 94
Cdd:cd17330 18 VLPFYVREFNKLGASgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194391024 95 GLAQGlGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSwrstLALSGALCVVVSFLCLLLIH 172
Cdd:cd17330 98 GLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG----YALPFLVAAALALLNLVLVL 170
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
240-394 |
3.91e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.10 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 240 GQSALVGSSYMsaleVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLLFMMAGMTVSmylfrVTVTSDSPKLWILVLG 319
Cdd:cd17504 31 AAVSWVLTAYL----LVGAVSTPILGRLGDL---------YG--RKKVLLIVLAIYTAG-----SLLAAFAPNLPVLIAG 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194391024 320 AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMaNVGGFLAGLPF-STIAKHYSWSTAFWVAEVICAASTAA 394
Cdd:cd17504 91 RALQGIGGAVFPLAFALVREEFPPERVPVAQGILSAT-FGIGAGIGLPLgGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
17-361 |
4.02e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 39.21 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 17 FVMPSLVEEIP-----LDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSsGLLLVGLVNIFFAWSSTVP--VFAA 89
Cdd:TIGR00886 18 FAFSPLAVFLIkddlgLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTA-LSLLLLAIPCLWAGLAVQSysVLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 90 LWFLNGLAqGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLAL---SGALCVVVSFL 166
Cdd:TIGR00886 97 IRLFIGIA-GGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQPAhlaWGWAFVIVPAG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 167 CLLLIHNEPADVGLRNLDPMPSEGKkgsLKEESTLQeLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVG 246
Cdd:TIGR00886 176 ILLLPALLIFFVGADTPPGKPATGK---LSFKEALK-VFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 247 SSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMtVSMYLFRVTVTSDSPKLWILVLGAVFGFSS 326
Cdd:TIGR00886 252 GAYASLGGFLGSLARPAGGAISDR---------LGGARKLLMNFLGVAM-GAFLVVLGLVSDGSLAAFIVLFVALFFFAG 321
|
330 340 350
....*....|....*....|....*....|....*
gi 194391024 327 YGPIALFGVIANESAPPNlcGTSHAIVGLMANVGG 361
Cdd:TIGR00886 322 AGNGSTFALVPHIFRRAT--GAVSGLIGAIGNLGG 354
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
18-399 |
4.15e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.10 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 18 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 97
Cdd:cd17504 18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 98 QGLgWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLlihnepad 177
Cdd:cd17504 98 GAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPL-------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 178 VGLRnldpmpsegkkgslkeestlqeLLLSPYLWVLSTGYLvVFGVKTCCTDWGQFFLIQEK-----GQSALVGSSYMSA 252
Cdd:cd17504 169 IDLR----------------------LLRRRNVLLANITAL-LAGFGMFMVFQLLPQLLQLPtptgfGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 253 LEVGGLVGSIAAGYLSDRAMAKAglsnygnprhgLLLFMMAGMTVSMYLFRVTVTSdspkLWILVLGAVFGFSSYG--PI 330
Cdd:cd17504 226 GALVMLIAGPLAGRLIARVGPRR-----------VLLIGLVISAVGLLLLALLHSS----LWALVVALLLIGIGLGlaFA 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 331 ALFGVIAnESAPPNLCGTSHAIVGLMANVGG-------------FLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFL 397
Cdd:cd17504 291 SLPNIVV-ESVPPDRTGIATGMNTVLRTIGSaigpaiagailttYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLL 369
|
..
gi 194391024 398 LR 399
Cdd:cd17504 370 IP 371
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
1-172 |
5.15e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.15 E-value: 5.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 1 MFGGYSLYYFNRKTFSFVMPSLVEEIPlDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 80
Cdd:cd06179 3 LCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 81 SSTVPVFAALWFLNGLA---QGLGWPPCGKVLrkwfEPSQFGTWWAILSTSMNLAGGLGPILATILAQSY--SWRSTLAL 155
Cdd:cd06179 82 AKSVNMLIGGQALIGIGagtQGLGAAVASELV----PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYI 157
|
170
....*....|....*..
gi 194391024 156 SGALCVVVSFLCLLLIH 172
Cdd:cd06179 158 NAIFNALALILLFFFYH 174
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
231-398 |
5.46e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 231 GQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLLFMMAGMTVSMYLFRVTVTSDS 310
Cdd:cd17357 36 DRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANR---------FG--RKNGLLISNALLVVSSLLMFLSKSAKS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 311 PKLWIL--VLGAVFGFSSYGPIALFgviANESAPPNLCGTSHAIVGLMANVG---GFLAGLPFsTIAKHYSWSTAFWVAE 385
Cdd:cd17357 105 PELLIFgrFLVGIACGLSTGFVPMY---LQEISPSELRGALGSLTQIGVTLGillGQVFGLPS-VLGTETLWPYLLFFPG 180
|
170
....*....|...
gi 194391024 386 VICAASTAAFFLL 398
Cdd:cd17357 181 IPALLQLAALPFF 193
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
136-399 |
6.81e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.75 E-value: 6.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 136 GPILATILAQSY------SWRSTLALSGALCVVVSFLCLLLihnepadvgLRNLDPMPSEGKKGSLKEES--------TL 201
Cdd:PRK08633 155 GTALFSFLFESVngntpsEILGRIAPAGLVLLAVAVLGLIF---------AYRLPKVPAAAPEVFDKKKYlfpkllwrNL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 202 QELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGL-VGSIAAGYLSDRAMAkaglsny 280
Cdd:PRK08633 226 KLLRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIgIGSLLAGRLSGRHIE------- 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 281 gnprHGLLLFMMAGMTVSMYLFrvtVTSDSPkLWILVLGAVFGFSSygpiALFGVIANE----SAPPNLCGTSHAIVGLM 356
Cdd:PRK08633 299 ----LGLVPLGALGLALSLFLL---PTAPSL-ASVLVLFFLFGFSA----GLFIVPLNAliqfRAPEKELGKVLAANNFL 366
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 194391024 357 ANVGGFLAgLPFSTIAKHYSWSTA--FWVAEVICAASTAA------FFLLR 399
Cdd:PRK08633 367 QNVGMLLF-LALTTLFSGLGLSPAglFYLIALVTLIGTLYtllllpDSLLR 416
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
41-378 |
7.35e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 38.54 E-value: 7.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 41 SAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWF--------LNGLAQG--LGWPPcgKVLR 110
Cdd:cd17334 45 SLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLKCIPLGQQPKFallvlgqvLNALAQVlvLSLPP--LIAA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 111 KWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS-----YSWRSTLALSGALCVVVSFLCLLLIHNEPAdvglrnldP 185
Cdd:cd17334 123 VWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPpkgtkKEFGAVFYGEFGFACLLLALVLALFPPKPK--------Y 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 186 MPSEGKKGSLKEESTLQELLLSPYLWVLSTGY---LVVFGVKT-CCTDWGQFF-LIQEKGQSALVGSSYMSALE-VGGLV 259
Cdd:cd17334 195 PPSAASARQQNSEHVILELQKSISELLRNEPFvllAVAFSIMMgVFAGFSSVLaQILLPFGVSQTSAGWLGFFGiVAGMV 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 260 GSIAAGYLSDRA-MAKaglsnygnpRHGLLLFMMAgmTVSMYLFRVTVTSDSPKLWILVLGAVFGF-----SSYGPIALf 333
Cdd:cd17334 275 GGLLLGLFVDRTrMFK---------LIGLIILALG--TVVCTFFMLLVDRYGLPYVTLAFYLLCGLlgffqNSMVPIMF- 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 194391024 334 gVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWS 378
Cdd:cd17334 343 -ELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTE 386
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
123-396 |
7.58e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 7.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 123 AILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRnldpmpsegkkgslKEESTLQ 202
Cdd:cd17471 128 SVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKA--------------TPASSLV 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 203 ELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSA-LVGS--SYMSALEVgglVGSIAAGYLSDRAmakaglsn 279
Cdd:cd17471 194 KAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSEsWVGLlfGLAAALEI---PIMLLAGLLAKRF-------- 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 280 ygnprhGLLLFMMAGMTVSMYLFRVTVTSDSPklWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANV 359
Cdd:cd17471 263 ------GKRRLLLAGFLAGVLFYLGLALATSL--WQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRI 334
|
250 260 270
....*....|....*....|....*....|....*..
gi 194391024 360 GGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFF 396
Cdd:cd17471 335 GSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
16-167 |
7.64e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 38.28 E-value: 7.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 16 SFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMsARWlfsSGLLLVGLVNIFFAW-SSTVPVFAALWFLN 94
Cdd:cd17372 19 SFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKY-GRR---KGLIISALWTFYAGFlSAFAPNYMWLIILR 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194391024 95 GLAQ-GLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPI-LATILAQSYSWRSTLALSGALCVVVSFLC 167
Cdd:cd17372 95 CLVGlGLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEAsLAWLVMPRLGWRWLLAFSSVPSSLLLVFY 169
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
31-399 |
9.13e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 37.93 E-value: 9.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 31 DDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLL--VGLVNIFFAWSSTVPVFAALWflnglaQGLG----WPP 104
Cdd:cd17502 30 SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIfeLGSLLCGLAPNMTMLIVGRAI------QGIGggglMSL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 105 CGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRST----LALSGALCVVVSFLCLLLIHNepadvgl 180
Cdd:cd17502 104 AFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCfyinLPIGGLALALLRTILLSSIFG------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 181 rnldpmpsegkkgslkeestlqeLLLSPYLWVLSTgYLVVFgvktcctdwgqFFLIqeKGQSALVGSSYMSALEVGGLVG 260
Cdd:cd17502 177 -----------------------FLFGGALFGLIY-YLPLY-----------FQLV--LGDSATKSGVRLLPLIIGLVIG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194391024 261 SIAAGYLsdramakagLSNYGNPRHgLLLFMMAGMTVSMYLFrVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANES 340
Cdd:cd17502 220 SIISGAL---------ISKTGRYKP-LIVIGTILMSVGAGLL-TTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNA 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 194391024 341 APPNLCGTSHAIVGLMANVGGFLAGlpfstiakhySWSTAFWVAEVICAASTAAFFLLR 399
Cdd:cd17502 289 VPPADVGVATATNTFFRSLGGTLGV----------AITDVFLVALALAALAFLLSLFLP 337
|
|
| |
