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Conserved domains on  [gi|47077606|dbj|BAD18685|]
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unnamed protein product, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 413-528 6.48e-32

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.22  E-value: 6.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47077606   413 VVSGVFKHALtSLGYHRVVEISEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 491
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 47077606   492 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 528
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 317-411 1.03e-14

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 70.51  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47077606   317 QCASYNNKPFM-----GRFYEW-EPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPC-----DQNGT-AICVSGQCK 384
Cdd:pfam19236   9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgpREDGTlSLCVLGSCR 88

                          90       100
                  ....*....|....*....|....*..
gi 47077606   385 SIGCDDYLGSDKVVDKCGVCGGDNTGC 411
Cdd:pfam19236  89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 58-95 4.05e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 4.05e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47077606     58 AWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGA 95
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGE 40
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 413-528 6.48e-32

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.22  E-value: 6.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47077606   413 VVSGVFKHALtSLGYHRVVEISEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 491
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 47077606   492 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 528
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 317-411 1.03e-14

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 70.51  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47077606   317 QCASYNNKPFM-----GRFYEW-EPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPC-----DQNGT-AICVSGQCK 384
Cdd:pfam19236   9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgpREDGTlSLCVLGSCR 88

                          90       100
                  ....*....|....*....|....*..
gi 47077606   385 SIGCDDYLGSDKVVDKCGVCGGDNTGC 411
Cdd:pfam19236  89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 58-95 4.05e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 4.05e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47077606     58 AWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGA 95
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGE 40
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 58-78 2.93e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.80  E-value: 2.93e-04
                          10        20
                  ....*....|....*....|.
gi 47077606    58 AWGPWSACSRSCSGGVMEQTR 78
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTR 25
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 413-528 6.48e-32

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.22  E-value: 6.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47077606   413 VVSGVFKHALtSLGYHRVVEISEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 491
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 47077606   492 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 528
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 317-411 1.03e-14

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 70.51  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47077606   317 QCASYNNKPFM-----GRFYEW-EPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPC-----DQNGT-AICVSGQCK 384
Cdd:pfam19236   9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgpREDGTlSLCVLGSCR 88

                          90       100
                  ....*....|....*....|....*..
gi 47077606   385 SIGCDDYLGSDKVVDKCGVCGGDNTGC 411
Cdd:pfam19236  89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 58-95 4.05e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 4.05e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47077606     58 AWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGA 95
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGE 40
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 58-78 2.93e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.80  E-value: 2.93e-04
                          10        20
                  ....*....|....*....|.
gi 47077606    58 AWGPWSACSRSCSGGVMEQTR 78
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTR 25
TSP_1 pfam00090
Thrombospondin type 1 domain;
59-80 5.49e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.17  E-value: 5.49e-04
                          10        20
                  ....*....|....*....|..
gi 47077606    59 WGPWSACSRSCSGGVMEQTRPC 80
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTC 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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