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Conserved domains on  [gi|21752478|dbj|BAC04199|]
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unnamed protein product [Homo sapiens]

Protein Classification

DUF3398 domain-containing protein( domain architecture ID 10570933)

DUF3398 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DOCK_C-D_N super family cl13339
Dedicator of cytokinesis C/D, N terminal; This entry represents the N-terminal domain of the ...
 1-98 8.93e-33

Dedicator of cytokinesis C/D, N terminal; This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8) and DOCK-D subfamily (DOCK 9, 10, 11). DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases, required during several cellular processes, such as cell motility and phagocytosis. DOCK proteins are categorized into four subfamilies based on their sequence homology: DOCK-A (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11).


The actual alignment was detected with superfamily member pfam11878:

Pssm-ID: 463380  Cd Length: 112  Bit Score: 120.45  E-value: 8.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21752478     1 MTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEG-VELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKK 79
Cdd:pfam11878  14 SQHLTQIENDPLRDLLLFPDDDIEVSVIPRECRTLQPTVPEEAeKEADPLVRECIKTYTSDWHVVNYKYEDYSGDFRQLP 93

                          90
                  ....*....|....*....
gi 21752478    80 TGSRKDFHKTLPKQTFESE 98
Cdd:pfam11878  94 KSKRRERPEKLPKQVFEID 112
 
Name Accession Description Interval E-value
DOCK_C-D_N pfam11878
Dedicator of cytokinesis C/D, N terminal; This entry represents the N-terminal domain of the ...
 1-98 8.93e-33

Dedicator of cytokinesis C/D, N terminal; This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8) and DOCK-D subfamily (DOCK 9, 10, 11). DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases, required during several cellular processes, such as cell motility and phagocytosis. DOCK proteins are categorized into four subfamilies based on their sequence homology: DOCK-A (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11).


Pssm-ID: 463380  Cd Length: 112  Bit Score: 120.45  E-value: 8.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21752478     1 MTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEG-VELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKK 79
Cdd:pfam11878  14 SQHLTQIENDPLRDLLLFPDDDIEVSVIPRECRTLQPTVPEEAeKEADPLVRECIKTYTSDWHVVNYKYEDYSGDFRQLP 93

                          90
                  ....*....|....*....
gi 21752478    80 TGSRKDFHKTLPKQTFESE 98
Cdd:pfam11878  94 KSKRRERPEKLPKQVFEID 112
 
Name Accession Description Interval E-value
DOCK_C-D_N pfam11878
Dedicator of cytokinesis C/D, N terminal; This entry represents the N-terminal domain of the ...
 1-98 8.93e-33

Dedicator of cytokinesis C/D, N terminal; This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8) and DOCK-D subfamily (DOCK 9, 10, 11). DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases, required during several cellular processes, such as cell motility and phagocytosis. DOCK proteins are categorized into four subfamilies based on their sequence homology: DOCK-A (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11).


Pssm-ID: 463380  Cd Length: 112  Bit Score: 120.45  E-value: 8.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21752478     1 MTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEG-VELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKK 79
Cdd:pfam11878  14 SQHLTQIENDPLRDLLLFPDDDIEVSVIPRECRTLQPTVPEEAeKEADPLVRECIKTYTSDWHVVNYKYEDYSGDFRQLP 93

                          90
                  ....*....|....*....
gi 21752478    80 TGSRKDFHKTLPKQTFESE 98
Cdd:pfam11878  94 KSKRRERPEKLPKQVFEID 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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