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Conserved domains on  [gi|15621825|dbj|BAB65819|]
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N5-carboxyaminoimidazole ribonucleotide mutase [Sulfurisphaera tokodaii str. 7]

Protein Classification

5-(carboxyamino)imidazole ribonucleotide mutase( domain architecture ID 10000490)

5-(carboxyamino)imidazole ribonucleotide mutase catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR), a step in de novo purine nucleotide biosynthesis

CATH:  3.40.50.7700
EC:  5.4.99.18
Gene Ontology:  GO:0006164|GO:0003824|GO:0006189|GO:0034023
PubMed:  36748301|33179964
SCOP:  4003688

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PurE COG0041
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; ...
 2-153 9.89e-103

Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase is part of the Pathway/BioSystem: Purine biosynthesis


:

Pssm-ID: 439811  Cd Length: 161  Bit Score: 290.81  E-value: 9.89e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825   2 PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLP 81
Cdd:COG0041   1 PKVGIIMGSDSDWPTMKKAAKILDEFGIPYEVRVVSAHRTPDRLFEYAKTAEERGLKVIIAGAGGAAHLPGMVAAKTTLP 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825  82 VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLN 153
Cdd:COG0041  81 VIGVPVKSKALDGLDSLLSIVQMPPGVPVATVAIGGAKNAALLAAQILALKDPELAEKLKAYREEQTEKVLA 152
 
Name Accession Description Interval E-value
PurE COG0041
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; ...
 2-153 9.89e-103

Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439811  Cd Length: 161  Bit Score: 290.81  E-value: 9.89e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825   2 PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLP 81
Cdd:COG0041   1 PKVGIIMGSDSDWPTMKKAAKILDEFGIPYEVRVVSAHRTPDRLFEYAKTAEERGLKVIIAGAGGAAHLPGMVAAKTTLP 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825  82 VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLN 153
Cdd:COG0041  81 VIGVPVKSKALDGLDSLLSIVQMPPGVPVATVAIGGAKNAALLAAQILALKDPELAEKLKAYREEQTEKVLA 152
AIRC pfam00731
AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl) ...
 4-150 1.26e-92

AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


Pssm-ID: 459917  Cd Length: 147  Bit Score: 265.00  E-value: 1.26e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825     4 VAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLPVI 83
Cdd:pfam00731   1 VGIIMGSDSDLPVMKKAAKILKEFGIPYEVRVVSAHRTPERLLEYAKEAEERGLKVIIAGAGGAAHLPGMVAALTTLPVI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15621825    84 GVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNE 150
Cdd:pfam00731  81 GVPVKSSALDGLDSLLSIVQMPSGVPVATVAIGGAKNAALLAAQILALSDPELAEKLKEYREEMAEK 147
purE TIGR01162
phosphoribosylaminoimidazole carboxylase, PurE protein; Phosphoribosylaminoimidazole ...
 4-153 3.55e-87

phosphoribosylaminoimidazole carboxylase, PurE protein; Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, an N5-CAIR mutase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273474  Cd Length: 156  Bit Score: 251.38  E-value: 3.55e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825     4 VAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLPVI 83
Cdd:TIGR01162   1 VGIIMGSDSDLPTMKKAADILEEFGIPYELRVVSAHRTPELMLEYAKTAEERGIKVIIAGAGGAAHLPGMVAALTPLPVI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825    84 GVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLN 153
Cdd:TIGR01162  81 GVPVPSKALSGLDSLLSIVQMPSGVPVATVAIGNAGNAALLAAQILGIKDPELAEKLKEYRENQKEEVLK 150
AIRC smart01001
AIR carboxylase; Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl) ...
 2-151 3.12e-81

AIR carboxylase; Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


Pssm-ID: 214965  Cd Length: 152  Bit Score: 236.27  E-value: 3.12e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825      2 PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLP 81
Cdd:smart01001   1 PLVGIIMGSTSDLPVMEEAAKTLEEFGIPYEVGVASAHRTPDRLFEYAKEAEDRGIKVIIAGAGGAAHLPGVVAALTTLP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825     82 VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIG--GAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEV 151
Cdd:smart01001  81 VIGVPVSSGYLGGLDSLLSIVQMPSGIPVATVAIGidGAFNAALLAAQILALNDPELAAKLAAYRINQTEEV 152
PLN02948 PLN02948
phosphoribosylaminoimidazole carboxylase
 2-153 1.87e-77

phosphoribosylaminoimidazole carboxylase


Pssm-ID: 178534 [Multi-domain]  Cd Length: 577  Bit Score: 240.35  E-value: 1.87e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825    2 PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLP 81
Cdd:PLN02948 411 PLVGIIMGSDSDLPTMKDAAEILDSFGVPYEVTIVSAHRTPERMFSYARSAHSRGLQVIIAGAGGAAHLPGMVASMTPLP 490

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825   82 VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLN 153
Cdd:PLN02948 491 VIGVPVKTSHLDGLDSLLSIVQMPRGVPVATVAIGNATNAGLLAVRMLGASDPDLLDKMEAYQEDMRDMVLE 562
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
 92-145 8.52e-04

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


Pssm-ID: 239227  Cd Length: 292  Bit Score: 38.33  E-value: 8.52e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825  92 LNGLDSLLsivQMPYGvpvatvaiGGAKNAALLALRILGLKY--------PDIAEKVKKFME 145
Cdd:cd02897   2 LQNLDNLL---RMPYG--------CGEQNMVNFAPNIYVLDYlkatgqltPEIESKALGFLR 52
 
Name Accession Description Interval E-value
PurE COG0041
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; ...
 2-153 9.89e-103

Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439811  Cd Length: 161  Bit Score: 290.81  E-value: 9.89e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825   2 PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLP 81
Cdd:COG0041   1 PKVGIIMGSDSDWPTMKKAAKILDEFGIPYEVRVVSAHRTPDRLFEYAKTAEERGLKVIIAGAGGAAHLPGMVAAKTTLP 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825  82 VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLN 153
Cdd:COG0041  81 VIGVPVKSKALDGLDSLLSIVQMPPGVPVATVAIGGAKNAALLAAQILALKDPELAEKLKAYREEQTEKVLA 152
AIRC pfam00731
AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl) ...
 4-150 1.26e-92

AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


Pssm-ID: 459917  Cd Length: 147  Bit Score: 265.00  E-value: 1.26e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825     4 VAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLPVI 83
Cdd:pfam00731   1 VGIIMGSDSDLPVMKKAAKILKEFGIPYEVRVVSAHRTPERLLEYAKEAEERGLKVIIAGAGGAAHLPGMVAALTTLPVI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15621825    84 GVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNE 150
Cdd:pfam00731  81 GVPVKSSALDGLDSLLSIVQMPSGVPVATVAIGGAKNAALLAAQILALSDPELAEKLKEYREEMAEK 147
purE TIGR01162
phosphoribosylaminoimidazole carboxylase, PurE protein; Phosphoribosylaminoimidazole ...
 4-153 3.55e-87

phosphoribosylaminoimidazole carboxylase, PurE protein; Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, an N5-CAIR mutase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273474  Cd Length: 156  Bit Score: 251.38  E-value: 3.55e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825     4 VAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLPVI 83
Cdd:TIGR01162   1 VGIIMGSDSDLPTMKKAADILEEFGIPYELRVVSAHRTPELMLEYAKTAEERGIKVIIAGAGGAAHLPGMVAALTPLPVI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825    84 GVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLN 153
Cdd:TIGR01162  81 GVPVPSKALSGLDSLLSIVQMPSGVPVATVAIGNAGNAALLAAQILGIKDPELAEKLKEYRENQKEEVLK 150
AIRC smart01001
AIR carboxylase; Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl) ...
 2-151 3.12e-81

AIR carboxylase; Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


Pssm-ID: 214965  Cd Length: 152  Bit Score: 236.27  E-value: 3.12e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825      2 PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLP 81
Cdd:smart01001   1 PLVGIIMGSTSDLPVMEEAAKTLEEFGIPYEVGVASAHRTPDRLFEYAKEAEDRGIKVIIAGAGGAAHLPGVVAALTTLP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825     82 VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIG--GAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEV 151
Cdd:smart01001  81 VIGVPVSSGYLGGLDSLLSIVQMPSGIPVATVAIGidGAFNAALLAAQILALNDPELAAKLAAYRINQTEEV 152
PLN02948 PLN02948
phosphoribosylaminoimidazole carboxylase
 2-153 1.87e-77

phosphoribosylaminoimidazole carboxylase


Pssm-ID: 178534 [Multi-domain]  Cd Length: 577  Bit Score: 240.35  E-value: 1.87e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15621825    2 PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLP 81
Cdd:PLN02948 411 PLVGIIMGSDSDLPTMKDAAEILDSFGVPYEVTIVSAHRTPERMFSYARSAHSRGLQVIIAGAGGAAHLPGMVASMTPLP 490

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825   82 VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLN 153
Cdd:PLN02948 491 VIGVPVKTSHLDGLDSLLSIVQMPRGVPVATVAIGNATNAGLLAVRMLGASDPDLLDKMEAYQEDMRDMVLE 562
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
 92-145 8.52e-04

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


Pssm-ID: 239227  Cd Length: 292  Bit Score: 38.33  E-value: 8.52e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15621825  92 LNGLDSLLsivQMPYGvpvatvaiGGAKNAALLALRILGLKY--------PDIAEKVKKFME 145
Cdd:cd02897   2 LQNLDNLL---RMPYG--------CGEQNMVNFAPNIYVLDYlkatgqltPEIESKALGFLR 52
DUF4419 pfam14388
Domain of unknown function (DUF4419); This family of proteins is functionally uncharacterized. ...
 1-33 1.79e-03

Domain of unknown function (DUF4419); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 348 and 454 amino acids in length.


Pssm-ID: 433926  Cd Length: 302  Bit Score: 37.21  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15621825     1 MPKVaVIMGSKSDWEYMKEAVELLKQFGVEVEA 33
Cdd:pfam14388 130 IPSV-TLLGTREDWEKLLERLDRLAEFGEEMAW 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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