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Conserved domains on  [gi|12848494|dbj|BAB27975|]
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unnamed protein product [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-270 9.41e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 9.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  80 EAGVADLTWVGDKGILVAS-DSGAVELWELDENETLIVSKFckyeHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQV 158
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRG----HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 159 SLNSYRAHAGQVTCVAASPhKDSVFLSCSEDSRILLWDTRCPKPASQmaCNASGYLPTALAWHPqQSEVFVFGDENGSVS 238
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSP-DGYLLASGSEDGTIR 244

                       170       180       190
                ....*....|....*....|....*....|..
gi 12848494 239 LVDTKNASCTLSSAVHSQGVTRLVFSPHRCCV 270
Cdd:cd00200 245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-270 9.41e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 9.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  80 EAGVADLTWVGDKGILVAS-DSGAVELWELDENETLIVSKFckyeHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQV 158
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRG----HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 159 SLNSYRAHAGQVTCVAASPhKDSVFLSCSEDSRILLWDTRCPKPASQmaCNASGYLPTALAWHPqQSEVFVFGDENGSVS 238
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSP-DGYLLASGSEDGTIR 244

                       170       180       190
                ....*....|....*....|....*....|..
gi 12848494 239 LVDTKNASCTLSSAVHSQGVTRLVFSPHRCCV 270
Cdd:cd00200 245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276
WD40 COG2319
WD40 repeat [General function prediction only];
94-265 1.39e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 1.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  94 ILVASDSGAVELWELDENETLIVSKFckyeHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSLNSYRAHAGQVTCV 173
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTG----HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 174 AASPHkDSVFLSCSEDSRILLWDTRCPKPASQMacNASGYLPTALAWHPQqSEVFVFGDENGSVSLVDTKNASCTLSSAV 253
Cdd:COG2319 295 AFSPD-GKLLASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLRTLTG 370

                       170
                ....*....|..
gi 12848494 254 HSQGVTRLVFSP 265
Cdd:COG2319 371 HTGAVTSVAFSP 382
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 160-196 8.94e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 8.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 12848494    160 LNSYRAHAGQVTCVAASPHkDSVFLSCSEDSRILLWD 196
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 96-201 2.94e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494   96 VASDS--GAVELWELDENETLIVSKfckyEHDDIVSTVTVLSSG-TQAVSGSKDCCIKIWDLAQQVSLNSYRAHAgQVTC 172
Cdd:PLN00181 548 VASSNfeGVVQVWDVARSQLVTEMK----EHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICC 622

                         90       100
                 ....*....|....*....|....*....
gi 12848494  173 VAASPHKDSVFLSCSEDSRILLWDTRCPK 201
Cdd:PLN00181 623 VQFPSESGRSLAFGSADHKVYYYDLRNPK 651
WD40 pfam00400
WD domain, G-beta repeat;
160-196 3.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 12848494   160 LNSYRAHAGQVTCVAASPHkDSVFLSCSEDSRILLWD 196
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-270 9.41e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 9.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  80 EAGVADLTWVGDKGILVAS-DSGAVELWELDENETLIVSKFckyeHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQV 158
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRG----HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 159 SLNSYRAHAGQVTCVAASPhKDSVFLSCSEDSRILLWDTRCPKPASQmaCNASGYLPTALAWHPqQSEVFVFGDENGSVS 238
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSP-DGYLLASGSEDGTIR 244

                       170       180       190
                ....*....|....*....|....*....|..
gi 12848494 239 LVDTKNASCTLSSAVHSQGVTRLVFSPHRCCV 270
Cdd:cd00200 245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-265 1.18e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 1.18e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  80 EAGVADLTWVGDKGILV-ASDSGAVELWELDENETLIVSKfckyEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQV 158
Cdd:cd00200   9 TGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 159 SLNSYRAHAGQVTCVAASPHkDSVFLSCSEDSRILLWDTRCPKPASQMACNASGYlpTALAWHPQQSEVFVfGDENGSVS 238
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV--NSVAFSPDGTFVAS-SSQDGTIK 160

                       170       180
                ....*....|....*....|....*..
gi 12848494 239 LVDTKNASCTLSSAVHSQGVTRLVFSP 265
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSP 187
WD40 COG2319
WD40 repeat [General function prediction only];
94-265 1.39e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 1.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  94 ILVASDSGAVELWELDENETLIVSKFckyeHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSLNSYRAHAGQVTCV 173
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTG----HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 174 AASPHkDSVFLSCSEDSRILLWDTRCPKPASQMacNASGYLPTALAWHPQqSEVFVFGDENGSVSLVDTKNASCTLSSAV 253
Cdd:COG2319 295 AFSPD-GKLLASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLRTLTG 370

                       170
                ....*....|..
gi 12848494 254 HSQGVTRLVFSP 265
Cdd:COG2319 371 HTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
94-265 1.47e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 1.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  94 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSLNSYRAHAGQVTCV 173
Cdd:COG2319 135 LASGSADGTVRLWDLATGKLLRTLT----GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 174 AASPHkDSVFLSCSEDSRILLWDTRCPKPASQMacNASGYLPTALAWHPqQSEVFVFGDENGSVSLVDTKNASCTLSSAV 253
Cdd:COG2319 211 AFSPD-GKLLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG 286

                       170
                ....*....|..
gi 12848494 254 HSQGVTRLVFSP 265
Cdd:COG2319 287 HSGGVNSVAFSP 298
WD40 COG2319
WD40 repeat [General function prediction only];
80-265 2.25e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 2.25e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  80 EAGVADLTWVGD-KGILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQV 158
Cdd:COG2319 162 SGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 159 SLNSYRAHAGQVTCVAASPhKDSVFLSCSEDSRILLWDTRCPKPASQMACNASGylPTALAWHPqQSEVFVFGDENGSVS 238
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--VNSVAFSP-DGKLLASGSDDGTVR 313

                       170       180
                ....*....|....*....|....*..
gi 12848494 239 LVDTKNASCTLSSAVHSQGVTRLVFSP 265
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRSVAFSP 340
WD40 COG2319
WD40 repeat [General function prediction only];
90-265 3.61e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 3.61e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  90 GDKGILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSLNSYRAHAGQ 169
Cdd:COG2319  89 DGRLLASASADGTVRLWDLATGLLLRTLT----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 170 VTCVAASPhkDSVFL-SCSEDSRILLWDTRCPKPASQMacNASGYLPTALAWHPqQSEVFVFGDENGSVSLVDTKNASCT 248
Cdd:COG2319 165 VTSVAFSP--DGKLLaSGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                       170
                ....*....|....*..
gi 12848494 249 LSSAVHSQGVTRLVFSP 265
Cdd:COG2319 240 RTLTGHSGSVRSVAFSP 256
WD40 COG2319
WD40 repeat [General function prediction only];
81-198 2.16e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 2.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  81 AGVADLTWVGD-KGILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVS 159
Cdd:COG2319 289 GGVNSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 12848494 160 LNSYRAHAGQVTCVAASPHkDSVFLSCSEDSRILLWDTR 198
Cdd:COG2319 365 LRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-196 1.77e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 1.77e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  80 EAGVADLTWVGD-KGILVASDSGAVELWELDenetlivSKFCKYE---HDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLA 155
Cdd:cd00200 177 TGEVNSVAFSPDgEKLLSSSSDGTIKLWDLS-------TGKCLGTlrgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 12848494 156 QQVSLNSYRAHAGQVTCVAASPHKdSVFLSCSEDSRILLWD 196
Cdd:cd00200 250 TGECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
81-265 2.56e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 2.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494  81 AGVADLTWVGDKGILVASDSGAVELWELDENETLIVSKFckyEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSL 160
Cdd:COG2319  37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL---GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 161 NSYRAHAGQVTCVAASPhkDSVFL-SCSEDSRILLWDTRCPKPASQMACNASGylPTALAWHPqQSEVFVFGDENGSVSL 239
Cdd:COG2319 114 RTLTGHTGAVRSVAFSP--DGKTLaSGSADGTVRLWDLATGKLLRTLTGHSGA--VTSVAFSP-DGKLLASGSDDGTVRL 188

                       170       180
                ....*....|....*....|....*.
gi 12848494 240 VDTKNASCTLSSAVHSQGVTRLVFSP 265
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSP 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-265 5.21e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 5.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 122 YEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSLNSYRAHAGQVTCVAASPHKDSVFlSCSEDSRILLWDTRCPK 201
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12848494 202 PASQMACNASGylPTALAWHPqQSEVFVFGDENGSVSLVDTKNASCTLSSAVHSQGVTRLVFSP 265
Cdd:cd00200  85 CVRTLTGHTSY--VSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-267 1.70e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494 163 YRAHAGQVTCVAASPHKDsVFLSCSEDSRILLWDTrcpKPASQMACNASGYLP-TALAWHPqQSEVFVFGDENGSVSLVD 241
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDL---ETGELLRTLKGHTGPvRDVAASA-DGTYLASGSSDKTIRLWD 79

                        90       100
                ....*....|....*....|....*.
gi 12848494 242 TKNASCTLSSAVHSQGVTRLVFSPHR 267
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDG 105
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 160-196 8.94e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 8.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 12848494    160 LNSYRAHAGQVTCVAASPHkDSVFLSCSEDSRILLWD 196
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 96-201 2.94e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848494   96 VASDS--GAVELWELDENETLIVSKfckyEHDDIVSTVTVLSSG-TQAVSGSKDCCIKIWDLAQQVSLNSYRAHAgQVTC 172
Cdd:PLN00181 548 VASSNfeGVVQVWDVARSQLVTEMK----EHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICC 622

                         90       100
                 ....*....|....*....|....*....
gi 12848494  173 VAASPHKDSVFLSCSEDSRILLWDTRCPK 201
Cdd:PLN00181 623 VQFPSESGRSLAFGSADHKVYYYDLRNPK 651
WD40 pfam00400
WD domain, G-beta repeat;
160-196 3.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 12848494   160 LNSYRAHAGQVTCVAASPHkDSVFLSCSEDSRILLWD 196
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-153 1.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 12848494    124 HDDIVSTVTVLSSGTQAVSGSKDCCIKIWD 153
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
124-153 1.19e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.19e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 12848494   124 HDDIVSTVTVLSSGTQAVSGSKDCCIKIWD 153
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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