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Conserved domains on  [gi|929654891|dbj|BAA92655|]
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KIAA1417 protein [Homo sapiens]

Protein Classification

inhibitor of Bruton tyrosine kinase( domain architecture ID 13793853)

inhibitor of Bruton tyrosine kinase (IBtk) acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development; contains two BTB/POZ domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 1.95e-68

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 224.94  E-value: 1.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  763 KCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654891  843 FICSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-653 1.13e-46

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 162.46  E-value: 1.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  546 FFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSeftdiyqkdEDSAGCHLFVVEKVHP 625
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTS---------EDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*...
gi 929654891  626 DMFEYLLQFIYTDTCDFLTHGFKPRIHL 653
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKLQR 99
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 7.19e-28

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


:

Pssm-ID: 350575  Cd Length: 60  Bit Score: 107.21  E-value: 7.19e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  871 LTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKM 930
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.20e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 112.76  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSgiyIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  223 VEGLNGHncSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  302 EAVYTMGLNG-GQLGclldpNGEKC-VTAPRQVSALHHkdiaLSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 5.94e-14

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.22  E-value: 5.94e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929654891   47 IKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 1.95e-68

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 224.94  E-value: 1.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  763 KCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654891  843 FICSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-653 1.13e-46

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 162.46  E-value: 1.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  546 FFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSeftdiyqkdEDSAGCHLFVVEKVHP 625
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTS---------EDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*...
gi 929654891  626 DMFEYLLQFIYTDTCDFLTHGFKPRIHL 653
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKLQR 99
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 7.19e-28

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 107.21  E-value: 7.19e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  871 LTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKM 930
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.20e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 112.76  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSgiyIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  223 VEGLNGHncSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  302 EAVYTMGLNG-GQLGclldpNGEKC-VTAPRQVSALHHkdiaLSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 761-871 1.07e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 82.69  E-value: 1.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891   761 QKKCSFLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEavvIKESQN 840
Cdd:pfam00651    4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEEN 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 929654891   841 VDficSVLVVADQLLITRLKEICEVALTEKL 871
Cdd:pfam00651   80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 554-639 4.49e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 75.37  E-value: 4.49e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891   554 LREADEMdsiHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQ 633
Cdd:pfam00651    4 LREQGEL---CDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLE 67


                   ....*.
gi 929654891   634 FIYTDT 639
Cdd:pfam00651   68 FMYTGK 73
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 5.94e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.22  E-value: 5.94e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929654891   47 IKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 565-639 7.69e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 68.49  E-value: 7.69e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891    565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYTDT 639
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGK 62
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 769-867 7.77e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 68.49  E-value: 7.77e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891    769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEavVIKESQNVDficSVL 848
Cdd:smart00225    1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGK--LDLPEENVE---ELL 74

                            90
                    ....*....|....*....
gi 929654891    849 VVADQLLITRLKEICEVAL 867
Cdd:smart00225   75 ELADYLQIPGLVELCEEFL 93
Ank_2 pfam12796
Ankyrin repeats (3 copies);
25-116 1.54e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 1.54e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891    25 VTKGSENQIKAFLSSHCynAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVdllVKDKESGWTALHRSIFYGHIDCVWS 104
Cdd:pfam12796    5 AKNGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKL 79

                           90
                   ....*....|..
gi 929654891   105 LLKHGVSLYIQD 116
Cdd:pfam12796   80 LLEKGADINVKD 91
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
195-244 4.37e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 4.37e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 929654891   195 KGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVL 244
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 59-123 9.85e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 9.85e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891   59 VSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSAL 123
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
PHA02713 PHA02713
hypothetical protein; Provisional
 767-864 2.95e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.00  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWI--EASSCAALEMpIHSDILKVILDYLYTDEAvvikESQNVdfi 844
Cdd:PHA02713   25 LCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIirDLVTRVNLQM-FDKDAVKNIVQYLYNRHI----SSMNV--- 96

                          90       100
                  ....*....|....*....|
gi 929654891  845 CSVLVVADQLLITRLKEICE 864
Cdd:PHA02713   97 IDVLKCADYLLIDDLVTDCE 116
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 1.95e-68

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 224.94  E-value: 1.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  763 KCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654891  843 FICSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-653 1.13e-46

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 162.46  E-value: 1.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  546 FFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSeftdiyqkdEDSAGCHLFVVEKVHP 625
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTS---------EDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*...
gi 929654891  626 DMFEYLLQFIYTDTCDFLTHGFKPRIHL 653
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKLQR 99
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 7.19e-28

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 107.21  E-value: 7.19e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  871 LTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKM 930
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.20e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 112.76  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSgiyIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  223 VEGLNGHncSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  302 EAVYTMGLNG-GQLGclldpNGEKC-VTAPRQVSALHHkdiaLSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-354 1.48e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 106.60  E-value: 1.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRsgiyIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLV 223
Cdd:COG5184    19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN----VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  224 EGLngHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGiIPPPSSCNVPRQIQAkylKGRTIIGVAAGRFHTVLWTRE- 302
Cdd:COG5184    95 PGL--TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG-DGTTTNRLTPVQVDA---GLSGVVAIAAGGYHTCALKSDg 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 929654891  303 AVYTMGLNG-GQLGCLLDPNgekcVTAPRQVSALHH-KDIAL----SLVAASDGATVC 354
Cdd:COG5184   169 TVWCWGANSyGQLGDGTTTD----RPTPVQVGGLSGvVAVAAggdhSCALKSDGTVWC 222
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-854 3.34e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 88.76  E-value: 3.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMP-IHSDILKVILDYLYTDEAVVikesqNVDFIC 845
Cdd:cd18186     1 LCDVTLV-VGGREFPAHRAVLAARSPYFRAMFSSGMKESSS-SEIELDdVSPEAFEALLDYIYTGELEL-----SEENVE 73


                  ....*....
gi 929654891  846 SVLVVADQL 854
Cdd:cd18186    74 ELLAAADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 761-871 1.07e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 82.69  E-value: 1.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891   761 QKKCSFLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEavvIKESQN 840
Cdd:pfam00651    4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEEN 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 929654891   841 VDficSVLVVADQLLITRLKEICEVALTEKL 871
Cdd:pfam00651   80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-263 8.22e-18

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 86.57  E-value: 8.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRsgiyIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLV 223
Cdd:COG5184   220 VWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKV 295

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 929654891  224 EGLngHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
Cdd:COG5184   296 PGL--SGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGD 333
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 8.94e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 76.44  E-value: 8.94e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagchlfVVEKVHPDMFEYLLQFIYTDTCDF 642
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEI-------------ELDDVSPEAFEALLDYIYTGELEL 67
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 187-362 1.84e-16

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 82.33  E-value: 1.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  187 FHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLngHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPP 266
Cdd:COG5184     8 SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  267 PSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTREAVYTMGLNG-GQLGcllDPNGEKcVTAPRQVSALHHKDIAlsl 344
Cdd:COG5184    86 TDR-TTPVKVPG----LTGVVAVAAGYYHScALKSDGTVWCWGDNSsGQLG---DGTTTN-RLTPVQVDAGLSGVVA--- 153

                         170
                  ....*....|....*...
gi 929654891  345 VAASDGATVCVTTRGDIY 362
Cdd:COG5184   154 IAAGGYHTCALKSDGTVW 171
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 554-639 4.49e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 75.37  E-value: 4.49e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891   554 LREADEMdsiHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQ 633
Cdd:pfam00651    4 LREQGEL---CDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLE 67


                   ....*.
gi 929654891   634 FIYTDT 639
Cdd:pfam00651   68 FMYTGK 73
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 750-875 5.52e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 72.75  E-value: 5.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  750 AKNTGNKLKLSQKkcsfLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEaSSCAALEMP-IHSDILKVILDYLY 828
Cdd:cd18240     4 ACNVFNELRLEGK----LCDVVIR-VNGVEFPAHRNILCACSPYFRALFTNGWNE-TEKKVYKIPgVSPEMMELIIEYAY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 929654891  829 TDEAVVikESQNVDficSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18240    78 TRTVPI--TAENVE---ELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 775-871 1.73e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 71.17  E-value: 1.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  775 VDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAAlEMP------IHSDILKVILDYLYTDEAVVikesqNVDFICSVL 848
Cdd:cd18296    24 VEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNG-SIPvvtlhdVSPEVFAIVLYYIYTDDTDL-----PPENAYDVL 97

                          90       100
                  ....*....|....*....|...
gi 929654891  849 VVADQLLITRLKEICEVALTEKL 871
Cdd:cd18296    98 YVADMYLLPGLKRLCGTVLAQSL 120
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 757-867 3.98e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 69.98  E-value: 3.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  757 LKLSQKkcSFLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCaalEMPI----HSDILkVILDYLYTDeA 832
Cdd:cd18286     9 LQLFLN--GEDSDITIK-VDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS---EITLtgvsHAAVS-FVLLFIYGG-V 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 929654891  833 VVIKESQNvdfICSVLVVADQLLITRLKEICEVAL 867
Cdd:cd18286    81 LDLPDDVN---LGELLSLADMYGLDGLKDVVAYTL 112
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 5.94e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.22  E-value: 5.94e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929654891   47 IKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 565-639 7.69e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 68.49  E-value: 7.69e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891    565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYTDT 639
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGK 62
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 769-867 7.77e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 68.49  E-value: 7.77e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891    769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEavVIKESQNVDficSVL 848
Cdd:smart00225    1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGK--LDLPEENVE---ELL 74

                            90
                    ....*....|....*....
gi 929654891    849 VVADQLLITRLKEICEVAL 867
Cdd:smart00225   75 ELADYLQIPGLVELCEEFL 93
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 5.66e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.14  E-value: 5.66e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929654891   47 IKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDL 125
Cdd:COG0666   115 ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-875 1.18e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 66.35  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  765 SFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVikesqNVDFI 844
Cdd:cd18268    21 RILTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILI-----TRDNV 94

                          90       100       110
                  ....*....|....*....|....*....|.
gi 929654891  845 CSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18268    95 LPLMEAASMLQYPKLFEACSLYLQDQLTPEN 125
Ank_2 pfam12796
Ankyrin repeats (3 copies);
25-116 1.54e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 1.54e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891    25 VTKGSENQIKAFLSSHCynAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVdllVKDKESGWTALHRSIFYGHIDCVWS 104
Cdd:pfam12796    5 AKNGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKL 79

                           90
                   ....*....|..
gi 929654891   105 LLKHGVSLYIQD 116
Cdd:pfam12796   80 LLEKGADINVKD 91
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-863 2.66e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 64.67  E-value: 2.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSW-IEASSCAALE-MPIHSDILKVILDYLYTDEavvIKESQnvDFI 844
Cdd:cd18245    14 LCDATL-VVGGEEIPVQKNVLAAASPYFRAKLNYNPpKDDGSTYKIElEGISVEVMEEILDYIYTGQ---IKLSE--DNI 87

                          90
                  ....*....|....*....
gi 929654891  845 CSVLVVADQLLITRLKEIC 863
Cdd:cd18245    88 QDIVQAADLLLMTDLKDLC 106
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
195-244 4.37e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 4.37e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 929654891   195 KGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVL 244
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-875 6.42e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 64.02  E-value: 6.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  762 KKCSFLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYtDEAVVIKEsqnv 841
Cdd:cd18265    18 RRSGTFTDVVLL-VDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY-GGGLRIQE---- 91

                          90       100       110
                  ....*....|....*....|....*....|....
gi 929654891  842 DFICSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18265    92 DNVESVLEASDLLQVSKLREACVRFLEGQLHPCN 125
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-875 6.75e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 64.11  E-value: 6.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTM--KSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMPIHS-------DILKVILDYLYTDE 831
Cdd:cd18241    17 QRKQGLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRS-GRVEMRKWSsepgpdpDTVEAVIQYMYTGR 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 929654891  832 AVVikESQNVDficSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18241    96 IRV--STGNVH---EVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 7.43e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 64.05  E-value: 7.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVikESQNVDficS 846
Cdd:cd18237    21 LCDVIL-IVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISV--NSNNVQ---S 94

                          90       100
                  ....*....|....*....|....*....
gi 929654891  847 VLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18237    95 LLDAANQYQIEPVKKMCVDFLKEQLDASN 123
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
247-299 8.77e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 58.30  E-value: 8.77e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 929654891   247 DGCVYTFGLNIFHQLGiIPPPSSCNVPRQIQAkyLKGRTIIGVAAGRFHTVLW 299
Cdd:pfam00415    1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 752-875 8.97e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 60.53  E-value: 8.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  752 NTGNKLKlsqkKCSFLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDE 831
Cdd:cd18242    10 NTMNSLR----KSNTLCDVTLR-VEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTET 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 929654891  832 AVVIKEsqNVDficSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18242    85 VHVTVE--NVQ---ELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-641 1.15e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 60.39  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  547 FEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFlsDGNTSEftdiyqKDEDSAGCHLFVVEKVHPD 626
Cdd:cd18296     1 RVDLDELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALL--RDHFAE------SEENNGSIPVVTLHDVSPE 72

                          90
                  ....*....|....*
gi 929654891  627 MFEYLLQFIYTDTCD 641
Cdd:cd18296    73 VFAIVLYYIYTDDTD 87
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.34e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 60.22  E-value: 1.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKesQNVDficSVL 848
Cdd:cd18252    23 DITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITE--RNVQ---SLL 97

                          90       100
                  ....*....|....*....|....*..
gi 929654891  849 VVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18252    98 EAADLLQFISVKKACEQFLVRHLDIDN 124
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 767-871 1.36e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 59.56  E-value: 1.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMP-IHSDILKVILDYLYTDEavvIKESQNVDFIC 845
Cdd:cd18300     9 FSDVTFI-VEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-KEVELPgVSKETFLALLEYLYTDQ---APILEDGDCVG 83

                          90       100
                  ....*....|....*....|....*.
gi 929654891  846 sVLVVADQLLITRLKEICEVALTEKL 871
Cdd:cd18300    84 -LIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-876 1.80e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 59.78  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLcDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASscaALEMPIHS---DILKVILDYLYTDEAVVIKE 837
Cdd:cd18250    16 RAERKFF-DVTL-CAGGREFPCHRTVLAAASSYFRAMFAGELRESR---ADRVVLHGvsaEILGLLLDFSYTGRVTVTQD 90

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 929654891  838 sqNVDficSVLVVADQLLITRLKEICEVALTEKLTLKNA 876
Cdd:cd18250    91 --NVE---ALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 726-875 2.75e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 59.48  E-value: 2.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  726 KFDFSNLS----SRLDGVRFENEKINVIakntgnklklsqkkcsfLCdvtmksVDGKEFPCHKCVLCARLEYFHSMLSSS 801
Cdd:cd18236     1 KFDDTGLSlvlqNGLENLRLENSLTDVI-----------------LC------VDSQEFSCHRVVLAAASNYFRAMFCND 57

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 929654891  802 WIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKesQNVDficSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18236    58 LKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITK--QNVQ---RVLEAASLFQFLRMVDACASFLTEALHPEN 126
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 550-639 3.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 58.88  E-value: 3.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  550 FGKLLReaDEMDSihDVTFQVGNRLFPAHKYILAVHSDFFQKLF---LSDGNTSEftdiyqkdedsagchlFVVEKVHPD 626
Cdd:cd18280     5 FGALLE--SEEGA--DVTFNVDGEKFRAHKLVLAARSPVFRSMLfgpMREENEGE----------------IVIEDVEPP 64

                          90
                  ....*....|...
gi 929654891  627 MFEYLLQFIYTDT 639
Cdd:cd18280    65 VFKALLHFIYKDE 77
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 543-637 8.94e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 57.68  E-value: 8.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  543 SSSFFEEFGKLLREADemdsIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDgNTSEftdiyqkdedsagCHLFVVEK 622
Cdd:cd18292     1 SREFLQDIAQLYNNEE----LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSND-WWSE-------------SKQSEIEL 62

                          90
                  ....*....|....*....
gi 929654891  623 VHPD----MFEYLLQFIYT 637
Cdd:cd18292    63 VEDPecaaVFEKFLRYLYT 81
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 56.76  E-value: 1.80e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTdiyqkdedsagchlFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18224    28 DVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVART--------------YVVDFITPANFEKVLSFIYT 86
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 546-645 2.95e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 56.10  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  546 FFEEFGKLLreadEMDSIHDVTFQVGNRLFP--AHKYILAVHSDFFQKLFL----SDGNTSEFtdiyqkdedsagchlfV 619
Cdd:cd18294     1 FAADMKSLI----NNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFLtgpqKESTQSPL----------------V 60

                          90       100
                  ....*....|....*....|....*.
gi 929654891  620 VEKVHPDMFEYLLQFIYTDTCDFLTH 645
Cdd:cd18294    61 LSDIEPEVFRAVLEFIYTNCVTLSNH 86
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 232-354 3.32e-09

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 60.38  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  232 SQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHTVLWTRE-AVYTMGLN 310
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPG----LSNVVAVAAGGDHTCALKADgTVWCWGNN 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 929654891  311 G-GQLGclldpNGEK-CVTAPRQVSALHH-KDIAL----SLVAASDGATVC 354
Cdd:COG5184    76 SyGQLG-----DGTTtDRTTPVKVPGLTGvVAVAAgyyhSCALKSDGTVWC 121
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-863 3.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 55.90  E-value: 3.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  762 KKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKEsqNV 841
Cdd:cd18235    16 RKQNLLCDVIL-VADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEE--NV 92

                          90       100
                  ....*....|....*....|..
gi 929654891  842 DficSVLVVADQLLITRLKEIC 863
Cdd:cd18235    93 Q---VLLPAANLLQLTDVRDAC 111
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-863 4.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 55.87  E-value: 4.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  755 NKLKLSQKkcsfLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVV 834
Cdd:cd18256    12 NKLRGQHE----FCDVQLQ-VGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV 86

                          90       100
                  ....*....|....*....|....*....
gi 929654891  835 ikESQNVDficSVLVVADQLLITRLKEIC 863
Cdd:cd18256    87 --TVSNVQ---ELLVAADMLQLTEVVEIC 110
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-638 4.50e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 55.72  E-value: 4.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  547 FEEFgklLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDgntseftdiyQKDEDSAGchlFVVEKVHPD 626
Cdd:cd18295     6 YDEF---LRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETK----------WKDKREIN---LKHPLVNPD 69

                          90
                  ....*....|..
gi 929654891  627 MFEYLLQFIYTD 638
Cdd:cd18295    70 AFRALLQYLYTG 81
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 764-880 5.06e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 56.37  E-value: 5.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  764 CSFLCDVTMKSV-------DGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEavVIK 836
Cdd:cd18273    23 ARLLTDVTIEVNgpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGR--VTL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 929654891  837 ESQNVDficSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLL 880
Cdd:cd18273   101 SEANVQ---RLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-864 5.34e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 55.33  E-value: 5.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  768 CDVTMK-SVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALE-MPIHSDILKVILDYLYTDEAvvikeSQNVDFIC 845
Cdd:cd18294    15 SDVKFLvGPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlSDIEPEVFRAVLEFIYTNCV-----TLSNHTVI 89

                          90
                  ....*....|....*....
gi 929654891  846 SVLVVADQLLITRLKEICE 864
Cdd:cd18294    90 EVLAAAVEYGLDELRKLCE 108
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 5.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 55.36  E-value: 5.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMP-IHSDILKVILDYLYTDEAVVIKESQNVdfIC 845
Cdd:cd18297    12 MSDVTFL-VEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQT-PVIEIPdIRYDIFQLMMQYLYTGGVESLDVAQDD--AL 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 929654891  846 SVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18297    88 ELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-871 5.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 55.61  E-value: 5.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKEsqNVDFIcs 846
Cdd:cd18253    18 FTDVII-CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTE--NVQYL-- 92

                          90       100
                  ....*....|....*....|....*
gi 929654891  847 vLVVADQLLITRLKEICEVALTEKL 871
Cdd:cd18253    93 -FETSSLFQISPLRDACAKFLEEQL 116
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-876 7.26e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 55.24  E-value: 7.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAvvikesQNVDFIC-SV 847
Cdd:cd18345    20 DVTL-CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKA------PNLDKMAdDL 92

                          90       100
                  ....*....|....*....|....*....
gi 929654891  848 LVVADQLLITRLKEICEVALTEKLTLKNA 876
Cdd:cd18345    93 LAAADKYALERLKVMCEEALCSNLSVENV 121
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 767-871 7.60e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 54.86  E-value: 7.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAaleMPIH---SDILKVILDYLYTDEAVVIKESQNVdf 843
Cdd:cd18360    10 LADVVFK-IQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFL---VPIYgvsKDTFLSFLEYLYTDSCCPASILQAM-- 83

                          90       100
                  ....*....|....*....|....*...
gi 929654891  844 icSVLVVADQLLITRLKEICEVALTEKL 871
Cdd:cd18360    84 --ALLICAEMYQVSRLQHICELYIITQL 109
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-867 8.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 55.03  E-value: 8.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  768 CDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASS-CAALEmPIHSDILKVILDYLYTDE-------AVVIKESQ 839
Cdd:cd18280    15 ADVTF-NVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEgEIVIE-DVEPPVFKALLHFIYKDElpddvepAGSDSSSL 92

                          90       100
                  ....*....|....*....|....*...
gi 929654891  840 NVDFICSVLVVADQLLITRLKEICEVAL 867
Cdd:cd18280    93 DTTMAQHLLAAADRYALERLRLLCESRL 120
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.21e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 53.89  E-value: 1.21e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagchlfVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18314     8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEV-------------TLEDVEPEIFETVLKYMYT 67
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-863 1.39e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 54.21  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTdeAVVIKESQNVDficS 846
Cdd:cd18247    19 LCDVTLK-VGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS--GRIAIDTSNVQ---S 92

                          90
                  ....*....|....*..
gi 929654891  847 VLVVADQLLITRLKEIC 863
Cdd:cd18247    93 LLVGASFLQLQSVKDAC 109
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 741-853 1.60e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 54.16  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  741 FENEKINVIAKNTGNkLKLSQKkcsfLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEaSSCAALEMP-IHSDI 819
Cdd:cd18287     1 GEIDHVHFLSEDIGA-LFLNEE----YSDVTF-VVEEKRFPAHRVILAARSEYFRALLYGGMRE-SQQSEIELKdTNAEA 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 929654891  820 LKVILDYLYTDEAVVIKESQnvDFICSVLVVADQ 853
Cdd:cd18287    74 FKALLKYIYTGRLTLTDLKE--DVLLDVLGLAHQ 105
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 536-637 1.96e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 53.78  E-value: 1.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  536 YEIPAVSSSSffEEFGKLLREADemdsIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGc 615
Cdd:cd18287     1 GEIDHVHFLS--EDIGALFLNEE----YSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEA- 73

                          90       100
                  ....*....|....*....|..
gi 929654891  616 hlfvvekvhpdmFEYLLQFIYT 637
Cdd:cd18287    74 ------------FKALLKYIYT 83
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-645 3.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 53.56  E-value: 3.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFlsdgnTSEFTDIYQKDEDSAGchlfvvekVHPDMFEYLLQFIYTDTCDFLT 644
Cdd:cd18256    22 DVQLQVGMELFSVHRLVLAASSPYFAALF-----AGGMSESSKDVVQIHG--------VEPDIFHILLDFIYTGVVEVTV 88


                  .
gi 929654891  645 H 645
Cdd:cd18256    89 S 89
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 769-863 3.22e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 53.02  E-value: 3.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEaSSCAALEMP-IHSDILKVILDYLYTDEAvvikESQnVDFICSV 847
Cdd:cd18295    21 DVTF-NVHGESFPAHRCILSARSPYFAEMFETKWKD-KREINLKHPlVNPDAFRALLQYLYTGRL----EIH-VDDVEDC 93

                          90       100
                  ....*....|....*....|
gi 929654891  848 LVVADQ----LLITRLKEIC 863
Cdd:cd18295    94 KRLAKQcrleELIEELEAKC 113
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 749-875 3.58e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 53.08  E-value: 3.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  749 IAKNTGNKLKLSQ-KKCSFLcdvtmksVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYL 827
Cdd:cd18343     8 LAEDLGNLWENSRfTDCSLF-------VGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 929654891  828 YTDEAvvikesQNVDFIC-SVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18343    81 YTGKA------PNLDKMAdNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-864 4.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 53.04  E-value: 4.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  755 NKLKLSQKKCSFLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEM-PIHSDILKVILDYLYTDEAV 833
Cdd:cd18207    15 HNLNQQRKSGGRFCDVLLR-VGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMhTISSKVFGDILDFAYTSRIV 93

                          90       100       110
                  ....*....|....*....|....*....|.
gi 929654891  834 VIKESqnvdfICSVLVVADQLLITRLKEICE 864
Cdd:cd18207    94 VRLES-----FPELMTAAKFLLMRSVIDICQ 119
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-864 5.63e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 52.68  E-value: 5.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAaleMPIH---SDILKVILDYLYTDEAVVikesqNVDF 843
Cdd:cd18238    15 LCDVTLK-VGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDS---ITIKdidEEAVELLVDFAYTGKLTL-----TVDN 85

                          90       100
                  ....*....|....*....|.
gi 929654891  844 ICSVLVVADQLLITRLKEICE 864
Cdd:cd18238    86 VQSLLYAASLLQVEEVAKACC 106
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-876 6.70e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 52.26  E-value: 6.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVikesqNVDFICS 846
Cdd:cd18306    18 FCDVIL-QVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEV-----PADLVKS 91

                          90       100       110
                  ....*....|....*....|....*....|
gi 929654891  847 VLVVADQLLITRLKEICEVALTEKLTLKNA 876
Cdd:cd18306    92 VYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-864 6.93e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 52.29  E-value: 6.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASS---CAALEMPIHSDILKVILDYLYTDEAVVikesqNVDF 843
Cdd:cd18292    17 LSDIVLR-VGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKqseIELVEDPECAAVFEKFLRYLYTGQISV-----NLET 90

                          90       100
                  ....*....|....*....|.
gi 929654891  844 ICSVLVVADQLLITRLKEICE 864
Cdd:cd18292    91 ALPLLMLADKYNVTDLKQLCV 111
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 9.38e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 52.52  E-value: 9.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEM-PIHSDILKVILDYLYTDEAVVIKEsqNVD-FI 844
Cdd:cd18259    32 LSDVTL-LVGGREFPCHRSVLALCSHYFNAMFTGDFVESIS-ARVEIkDVDPAVMESLIDFAYTGKLTINQG--NVEaLI 107

                          90       100       110
                  ....*....|....*....|....*....|.
gi 929654891  845 CSvlvvADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18259   108 RT----SNRLQFPTVRKVCSRYLQQQIDATN 134
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 1.01e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 1.01e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929654891   47 IKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDL 125
Cdd:COG0666   181 ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDND-GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-876 1.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 52.27  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  775 VDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIkesQNVDFICSVLVVADQL 854
Cdd:cd18344    30 VAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHL---HSHSMACDVLAAADKY 106

                          90       100
                  ....*....|....*....|..
gi 929654891  855 LITRLKEICEVALTEKLTLKNA 876
Cdd:cd18344   107 GLEGLKVLCEDALCRNLSVENA 128
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 1.10e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 51.63  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVikesqNVDFICS 846
Cdd:cd18255    18 LLDVTL-IADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTL-----DLDCIQD 91

                          90       100
                  ....*....|....*....|....*....
gi 929654891  847 VLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18255    92 VLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-637 1.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 51.88  E-value: 1.12e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 929654891  564 HDVTFQVGNRLFPAHKYILAVHSdffQKLFlsdgntseftDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18306    19 CDVILQVGGHEIPAHRAVLACAS---PYLF----------ELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYT 79
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 759-876 1.42e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 51.53  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  759 LSQKKCSF----LCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEaVV 834
Cdd:cd18274    10 LQQLKAMYdegqLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSR-VT 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 929654891  835 IKESqNVDficSVLVVADQLLITRLKEICEVALTEKLTLKNA 876
Cdd:cd18274    89 LTEA-NVQ---ALFTAASIFQIPSLQDQCAQFMISRLDPQNS 126
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-864 1.96e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 50.72  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMPIHS-DILKVILDYLYTDEAvvikeSQNVDFICSV 847
Cdd:cd18298    14 DLKFR-VDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDK-NVIEIDQYSyPVYYAFLRYLYTDQV-----DLPPEDAIGL 86

                          90
                  ....*....|....*..
gi 929654891  848 LVVADQLLITRLKEICE 864
Cdd:cd18298    87 LDLANSYCEERLKKLCE 103
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 757-871 2.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 51.91  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  757 LKLSQKKCSFlCDVTMKSvDGKEFPCHKCVLCARLEYFHSMLSSSWIEA-SSCAALEMPIHSDILKVILDYLYTDEAVVI 835
Cdd:cd18267    31 LNLLRQQRLF-TDVLLHA-GNRSFPCHRAVLAACSRYFEAMFSGGLKESqDSEVNFHDSIHPEVLELLLDYAYSSRVIIN 108

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 929654891  836 KESQNvdficSVLVVADQLLITRLKEICEVALTEKL 871
Cdd:cd18267   109 EENAE-----SLLEAGDMLEFQDIRDACAEFLEKNL 139
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-854 2.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 51.17  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  755 NKLKLSQKKCSFlCDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSSSWIEA-SSCAALEMPIHSDILKVILDYLYTDEAV 833
Cdd:cd18254    11 THLNTLRKQCMF-TDVTLWAGN-RSFPCHRAVLAACSRYFEAMFSNGLRESlDSTVNFHDSLHPEVLELLLDFAYSSRII 88

                          90       100
                  ....*....|....*....|.
gi 929654891  834 VIKESQNvdficSVLVVADQL 854
Cdd:cd18254    89 INEENAE-----SLLEAGDML 104
Ank_2 pfam12796
Ankyrin repeats (3 copies);
56-123 3.15e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.73  E-value: 3.15e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 929654891    56 LHLVSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHgVSLYIQDkEGLSAL 123
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTAL 65
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 3.76e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 50.22  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKEsqnvdFICSVL 848
Cdd:cd18279    20 DCCL-CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK-----MADDLL 93

                          90       100
                  ....*....|....*....|....*..
gi 929654891  849 VVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18279    94 AAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-863 4.44e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 50.17  E-value: 4.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMKSvDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMP-IHSDILKVILDYLYTDEAVVIKESQ 839
Cdd:cd18293     9 QQNSGVFCDVLLQA-EGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQgLKAHTLLKLVDFLYTSELEVSSEEA 87

                          90       100
                  ....*....|....*....|....
gi 929654891  840 NvdficSVLVVADQLLITRLKEIC 863
Cdd:cd18293    88 Q-----DVLAAARRLQISELESLC 106
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-875 6.50e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 49.83  E-value: 6.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  775 VDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVikESQNVDFICSvlvVADQL 854
Cdd:cd18340    34 IKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEI--TEQNVQDIFA---AANMF 108

                          90       100
                  ....*....|....*....|.
gi 929654891  855 LITRLKEICEVALTEKLTLKN 875
Cdd:cd18340   109 QIPSIFTVCVSFLQKRLCLSN 129
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-863 7.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 49.69  E-value: 7.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  755 NKLKLSQKkcsfLCDVTMK---SVDGKEFPCHKCVLCARLEYFHSMLSSSWIEassCAALEMPI---HSDILKVILDYLY 828
Cdd:cd18248    13 NELRLSQQ----LCDVTLKvkyQDPKEEFMAHKVVLASSSPYFKAMFTSGLRE---CGMEVVPIegvHPCVMSRLIEFAY 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 929654891  829 TDEAVVIKESqnvdfICSVLVVADQLLITRLKEIC 863
Cdd:cd18248    86 TASISVGEKC-----VLHVLPGAVMYQMDSVVKAC 115
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-875 8.99e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 49.01  E-value: 8.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMP-IHSDILKVILDYLYTDEAVVIKesqnvDFIC 845
Cdd:cd18352    13 LSDVTF-LVEGRRFYAHRIALLASSDAFRAMFDGGYREKEA-RDIEIPnIRWEVFELMMRFIYTGSVDITN-----DIAK 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 929654891  846 SVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18352    86 DLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 48.86  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMKsVDGKEFPCHKCVLCARleyfhsmlSSSWIEASSCAALEMP---IHSDILKVILDYLYTDEavvIKESQNVDFIC 845
Cdd:cd18303    20 DITIK-LADKSIPAHKFVLAAR--------SEKWSNENLASTNELDlsdISYEVVLALLRWLYTDE---LDLTLDDEFLL 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 929654891  846 SVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18303    88 ELMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-876 1.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 48.94  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  775 VDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAvvikesQNVDFIC-SVLVVADQ 853
Cdd:cd18342    29 VAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMAdDLLAAADK 102

                          90       100
                  ....*....|....*....|...
gi 929654891  854 LLITRLKEICEVALTEKLTLKNA 876
Cdd:cd18342   103 YALERLKVMCEDALCSNLSVENA 125
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 1.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 48.98  E-value: 1.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFlsdgnTSEFTDIYQKDEDSAGchlfvvekVHPDMFEYLLQFIYTDT 639
Cdd:cd18242    23 DVTLRVEGKEFPAHRIVLAACSDYFCAMF-----TSEMSEKGKSEVELQG--------LTASTMEILLDFVYTET 84
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 1.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 48.47  E-value: 1.43e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagchlfvvekvHPDMFEYLLQFIYTDTCDF 642
Cdd:cd18303    20 DITIKLADKSIPAHKFVLAARSEKWSNENLASTNELDLSDI------------------SYEVVLALLRWLYTDELDL 79
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 761-863 1.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 47.72  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSflcDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEaVVIKESQN 840
Cdd:cd18314     3 DSEFS---DVVLC-VGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQ-VTLSEENV 77

                          90       100
                  ....*....|....*....|...
gi 929654891  841 VDficsVLVVADQLLITRLKEIC 863
Cdd:cd18314    78 LD----LLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-863 1.94e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 48.14  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  765 SFLCDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVdfi 844
Cdd:cd18338    19 NLLCDVTIVAED-VEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQV--- 94

                          90
                  ....*....|....*....
gi 929654891  845 csVLVVADQLLITRLKEIC 863
Cdd:cd18338    95 --LLPAAGLLQLQDVKKTC 111
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-875 2.71e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 48.25  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  766 FLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEaSSCAALEMPIHSDI-LKVILDYLYTDEAvvikeSQNVDFI 844
Cdd:cd18264    27 FLCDVVLE-AEGNEFPAHRSLLACSSDYFRALFKDYTQE-SKARVIHLPVVSAAgLQRVLDFIYTSWL-----SLSLDTL 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 929654891  845 CSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18264   100 EDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
Ank_4 pfam13637
Ankyrin repeats (many copies);
52-102 3.16e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 3.16e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 929654891    52 GRNALHLVSSCGKKGVLDWLIQKGVDLLVKDkESGWTALHRSIFYGHIDCV 102
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVL 50
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-869 3.32e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 47.28  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMKSVdGKEFPCHKCVLCaRLEYFHSMLSSSWIEA-SSCAALEMP---IHSDILKVILDYLYTDEaVVIKESQNVdfi 844
Cdd:cd18305    17 DITICAL-GREWKLHKIYLC-QSGYFASMFSGSWKESkETVINLEIPddnITVEALNVVFGSLYRDE-IEIKPSRVV--- 90

                          90       100
                  ....*....|....*....|....*
gi 929654891  845 cSVLVVADQLLITRLKEICEVALTE 869
Cdd:cd18305    91 -SILAAATLLQLDGLIQQCSEVMKE 114
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 768-864 3.70e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 47.19  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  768 CDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSswiEASSCAALEMPIH--SDILKVILDYLYTDEAVVIKESqnvdfIC 845
Cdd:cd18311    15 CDLTLQFRDNEQLKVHRLVLSACTDYFNVLEQT---CEIVDDTLIMPNElqADAVVPVINFMYTGQLEFEEKS-----YG 86

                          90
                  ....*....|....*....
gi 929654891  846 SVLVVADQLLITRLKEICE 864
Cdd:cd18311    87 KLLRTAKELNMTVLLKLLE 105
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-220 5.13e-06

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 50.36  E-value: 5.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 929654891  143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRsgiyIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVP 220
Cdd:COG5184   269 TVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-637 5.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 46.67  E-value: 5.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  554 LREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDiyqkdedsagchlfvVEKVHPDMFEYLLQ 633
Cdd:cd18217     9 LNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLD---------------QSQVSADGFQKLLE 73


                  ....
gi 929654891  634 FIYT 637
Cdd:cd18217    74 FIYT 77
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-637 6.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 46.51  E-value: 6.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  549 EFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSagchlfvvekvhpDMF 628
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDE-------------EAV 67


                  ....*....
gi 929654891  629 EYLLQFIYT 637
Cdd:cd18238    68 ELLVDFAYT 76
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-872 7.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 46.88  E-value: 7.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSSSWIEAsscAALEMPIH---SDILKVILDYLYTDEAVVike 837
Cdd:cd18261    22 QRNDGILCDITLVAEEQK-FHAHKAVLAACSDYFRAMFSLCMVES---EADEVNLHgvtSLGLKQALDFAYTGQILL--- 94

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 929654891  838 sqNVDFICSVLVVADQLLITRLKEICEVALTEKLT 872
Cdd:cd18261    95 --EPGVIQDVLAAGSHLQLLELLSLCSHYLIQELN 127
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 7.78e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 45.82  E-value: 7.78e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYT 637
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKD-------------VDPDALWTLVQYCYT 62
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 59-123 9.85e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 9.85e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891   59 VSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSAL 123
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
Ank_5 pfam13857
Ankyrin repeats (many copies);
71-126 1.09e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 1.09e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 929654891    71 LIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLV 126
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 871-923 1.15e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 45.30  E-value: 1.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 929654891  871 LTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDL 923
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKEL 53
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-641 1.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 45.46  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  565 DVTFQVGN----RLFPAHKYILAVHSDFFQKLFLsdGNTSEftdiyQKDEdsagchlFVVEKVHPDMFEYLLQFIYTDTC 640
Cdd:cd18282     9 DVHFIVGPpggtQRIPAHKYVLATGSSVFYAMFY--GGLAE-----NKNE-------IEIPDVEPAAFLNLLRYLYCDEI 74


                  .
gi 929654891  641 D 641
Cdd:cd18282    75 D 75
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-689 1.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 46.16  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFlSDGntseftdIYQKDEDSAGCHlfvvEKVHPDMFEYLLQFIYTDtcdflt 644
Cdd:cd18254    24 DVTLWAGNRSFPCHRAVLAACSRYFEAMF-SNG-------LRESLDSTVNFH----DSLHPEVLELLLDFAYSS------ 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 929654891  645 hgfkpRIHLNknpEEYQGTLNSHLNKVNFHEDDNQKSAF---EVYKSN 689
Cdd:cd18254    86 -----RIIIN---EENAESLLEAGDMLQFHDVRDAAAEFlekNLYPSN 125
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 44.46  E-value: 1.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLsDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYT 637
Cdd:cd18315     3 DVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPD-------------VPYSELKALLDFIYT 61
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-871 1.51e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 45.05  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEaVVIKEsqnvDFICS 846
Cdd:cd18234     1 LCDVIL-IAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGR-LELKE----DNVES 74

                          90       100
                  ....*....|....*....|....*
gi 929654891  847 VLVVADQLLITRLKEICEVALTEKL 871
Cdd:cd18234    75 LLATACLLQLSEVVEACCGFLMKQL 99
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-863 1.53e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 45.70  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSS-SWIEASSCAALEMpIHSDILKVILDYLYTdeAVVIKESQ 839
Cdd:cd18326    19 QRTQGLLCDVVI-LVEGREFPTHRSVLAACSQYFKKLFTSgAVVDQQNVYEIDF-VSAEALTALLDFAYT--ATLTVSTS 94

                          90       100
                  ....*....|....*....|....
gi 929654891  840 NVDficSVLVVADQLLITRLKEIC 863
Cdd:cd18326    95 NVG---DILSAARLLEIPAVSHVC 115
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.69e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 45.56  E-value: 1.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFlsdgntseftdiyqKDEDSAGCHLFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18212    25 DITLIVENVQFRAHKALLAASSEYFSMMF--------------ADEGEVGQSIYMLEGMVAETFGALLEFIYT 83
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-875 1.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 45.80  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  768 CDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEmpihsdiLKVILDYLYTDEAVVikesqNVDFICSV 847
Cdd:cd18243    33 CDVTL-TAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIG-------LRLVLEYLYTANVTL-----SLDTVEEV 99

                          90       100
                  ....*....|....*....|....*...
gi 929654891  848 LVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18243   100 LSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 1.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 45.25  E-value: 1.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEftdiyqkdedsagcHLFVVEKVHPDMFEYLLQFIYTDT 639
Cdd:cd18209    20 DVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQ--------------SVFQLDFCEPDAFENVLNYIYSSS 80
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-844 2.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 44.08  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLssswIEASSC--AALEMP-IHSDILKVILDYLYTDEaVVIKESQNVDF 843
Cdd:cd18315     1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALL----KETPPDehPVIILPdVPYSELKALLDFIYTGE-VNVSQEQLESL 74


                  .
gi 929654891  844 I 844
Cdd:cd18315    75 L 75
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 548-642 2.58e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 44.51  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  548 EEFGKLLReaDEMDSihDVTFQVGNRL-FPAHKYILAVHSDFFQKLFLSdgntseFTDIyQKDEDsagchlfvvekVHPD 626
Cdd:cd18299     1 EDLRNLLH--SPSCA--DVVFILQGGVrIFAHRIVLAAASSVFADLFLM------MTVV-TLDSD-----------ITPE 58

                          90
                  ....*....|....*.
gi 929654891  627 MFEYLLQFIYTDTCDF 642
Cdd:cd18299    59 AFRRVLEFLYTGVLDE 74
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-841 2.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 44.78  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMP-IHSDILKVILDYLYTDEaVVIKESQ 839
Cdd:cd18223    12 QRIQGILCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQEIWISS-HVLELPdLKAEVFAEILNFIYSSK-VVVKRQE 88


                  ..
gi 929654891  840 NV 841
Cdd:cd18223    89 TV 90
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 566-642 2.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 43.81  E-value: 2.68e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654891  566 VTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagcHLFVVEkvhPDMFEYLLQFIYTDTCDF 642
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEI----------NLRDIS---PEDFRALLEFLYGGKRDL 64
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 3.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 44.44  E-value: 3.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  548 EEFGKLLreadEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDM 627
Cdd:cd18279     7 EDLGNLW----ENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND-------------VDPEV 69

                          90
                  ....*....|
gi 929654891  628 FEYLLQFIYT 637
Cdd:cd18279    70 FKEMMRFIYT 79
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 3.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 44.68  E-value: 3.68e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929654891  565 DVTFQVGNR----LFPAHKYILAVHSDFFQKLFlsdgnTSEFTDiyqkdedsagCHLFVV--EKVHPDMFEYLLQFIYT 637
Cdd:cd18248    23 DVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMF-----TSGLRE----------CGMEVVpiEGVHPCVMSRLIEFAYT 86
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-641 3.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 44.57  E-value: 3.71e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagchlfVVEKVHPDMFEYLLQFIYTDTCD 641
Cdd:cd18297    14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVI-------------EIPDIRYDIFQLMMQYLYTGGVE 77
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 3.91e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 44.70  E-value: 3.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEavVIKESQNVDFIcsvL 848
Cdd:cd18269    29 DCVLK-IGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSE--IDLNDQNVQDI---F 102

                          90       100
                  ....*....|....*....|....*..
gi 929654891  849 VVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18269   103 ALASRFQIPSIFTVCVSYLQKRLSLSN 129
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-841 5.88e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 43.87  E-value: 5.88e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 929654891  768 CDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMpIHSDILKVILDYLYTDEAVVIKESQNV 841
Cdd:cd18204    19 CDIAI-VVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDF-LRSDIFEEVLNYMYTAKISVKKEDVNL 90
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-863 7.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 42.87  E-value: 7.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  768 CDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIeassCAALEMPIHSDI-------LKVILDYLYTDEaVVIKEsQN 840
Cdd:cd18307     2 CDVVI-SVDNHSFAAHRNVLAAVSPFVKSLISSNDM----KATDELSITIDCdylspetVEQLLDYFYTGK-IVISE-KN 74

                          90       100
                  ....*....|....*....|...
gi 929654891  841 VDficSVLVVADQLLITRLKEIC 863
Cdd:cd18307    75 VE---DLLKGAKYFNIPRLKDHC 94
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-864 7.50e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 43.40  E-value: 7.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  774 SVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMPIHS-DILKVILDYLYTDEAVVIKEsqnvDFIcSVLVVAD 852
Cdd:cd18353    26 RVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMK-EVIEIDQFSyPVYRAFLEYLYTDSVDLPPE----DAI-GLLDLAT 99

                          90
                  ....*....|..
gi 929654891  853 QLLITRLKEICE 864
Cdd:cd18353   100 SYCENRLKKLCQ 111
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-880 8.29e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 43.84  E-value: 8.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  766 FLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEaVVIKES--QNVDF 843
Cdd:cd18270    25 LLTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGN-LAINDStvEQLYE 102

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 929654891  844 ICSVLVVADQLLitrlkeICEVALTEKLTLKNAAMLL 880
Cdd:cd18270   103 TACFLQVEDVLQ------RCREYLIKKINAENCVRLL 133
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 769-830 9.21e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 42.66  E-value: 9.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654891  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEM----PIHSDILKVILDYLYTD 830
Cdd:cd18301    20 DVVFQ-VGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCDVvhieKVPPEIFEQLLQFIYTD 84
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-831 9.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 43.64  E-value: 9.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891  767 LCDVTMKSvDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDE 831
Cdd:cd18276    21 LTDVVLVA-EGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSD 84
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-637 1.09e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 43.07  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  554 LREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFlsdgntSEFTdiyQKDedsagchLFVVEKVHPDMFEYLLQ 633
Cdd:cd18221     9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF------QDFT---QEP-------LVEIEGVSNMAFRHLIE 72


                  ....
gi 929654891  634 FIYT 637
Cdd:cd18221    73 FTYT 76
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.18e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 43.67  E-value: 1.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYT 637
Cdd:cd18259    34 DVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKD-------------VDPAVMESLIDFAYT 93
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-642 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 43.30  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  554 LREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSdgntseftdiyqkDEDSAGCHLFVVEKVHPDMFEYLLQ 633
Cdd:cd18341    18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLS-------------EESEEKKKEVVLDNVDPNIMDMILK 84


                  ....*....
gi 929654891  634 FIYTDTCDF 642
Cdd:cd18341    85 YLYSAEIDL 93
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 42.66  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  565 DVTFQVG----NRLFPAHKYILAVHSDFFQKLFLSDGNTSEfTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYTDTC 640
Cdd:cd18349    10 DVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVK-SEIHIPD-------------VEPAAFLILLKYMYSDEI 75


                  ..
gi 929654891  641 DF 642
Cdd:cd18349    76 DL 77
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
233-260 1.20e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 40.49  E-value: 1.20e-04
                           10        20
                   ....*....|....*....|....*...
gi 929654891   233 QVAAAKDHTVVLTEDGCVYTFGLNIFHQ 260
Cdd:pfam13540    3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-640 1.26e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 43.34  E-value: 1.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSdgNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYTDTC 640
Cdd:cd18213    23 DCTVAIGDVYFKAHRAVLAAFSNYFKMIFIH--QSSECIKIQPTD-------------IQPDIFSYLLHIMYTGKG 83
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-875 1.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 43.25  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  765 SFLCDVTMKSVDGKE-FPCHKCVLCARLEYFHSMLSSSWIEASscaALEMPIH--SDI-LKVILDYLYTDeavviKESQN 840
Cdd:cd18239    21 GLLCDVTLVPGDGDEtFPVHRAMMASASDYFKAMFTGGMKEQE---LMCIKLHgvSKIgLKNIIDFIYTA-----KLSLN 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 929654891  841 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18239    93 MDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 43.03  E-value: 1.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagchlfvvekVHPDMFEYLLQFIYT 637
Cdd:cd18334    23 DVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDM-----------------VNPTVFRQILDFIYT 78
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-641 1.38e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 42.70  E-value: 1.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFtdiyqkdedsagcHLFVVEKVHPDMFEYLLQFIYTDTCD 641
Cdd:cd18240    19 DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEK-------------KVYKIPGVSPEMMELIIEYAYTRTVP 82
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 755-870 1.52e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 43.03  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  755 NKLKLSQKKCSFlCDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEavv 834
Cdd:cd18358     9 NRIKECLSKGTF-SDVTFKLDDGT-INAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQ--- 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 929654891  835 IKESQNVDfICSVLVVADQLLITRLkeiceVALTEK 870
Cdd:cd18358    84 LSPTADLD-PLELIALANRFCLPHL-----VALTEQ 113
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-864 1.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 42.61  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLsSSWIEAS---SCAALEMpIHSDILKVILDYLYTDEAVVIKE 837
Cdd:cd18330    12 QRKRDFFCDCSI-IVEGRIFKAHRNILFANSGYFRALL-IHYIQDSgrhSTASLDI-VTSEAFSIILDFLYSGKLDLCSE 88

                          90       100
                  ....*....|....*....|....*..
gi 929654891  838 SqnvdfICSVLVVADQLLITRLKEICE 864
Cdd:cd18330    89 N-----VIEVMSAASYLQMTDVVNFCK 110
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-836 1.87e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 42.13  E-value: 1.87e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSswieASSCAALEMpIHSDILKVILDYLYTDEAVVIK 836
Cdd:cd18219    15 QRGHGLFCDVTV-IVEDRKFRAHKNILSASSTYFHQLFSV----AGQVVELNF-IRADIFAEILNYIYSSKIVRVR 84
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.91e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 42.78  E-value: 1.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagchlfVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18269    29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEV-------------VLEDVDPDVMGMILKYLYT 88
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 2.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 43.05  E-value: 2.10e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFlsDGNTSEFTDIYQKDEDSagchlfvvekVHPDMFEYLLQFIYT 637
Cdd:cd18267    42 DVLLHAGNRSFPCHRAVLAACSRYFEAMF--SGGLKESQDSEVNFHDS----------IHPEVLELLLDYAYS 102
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 750-875 2.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 42.34  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  750 AKNTGNKLK--LSQKKcsfLCDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYL 827
Cdd:cd18336     3 AEQTFRKMEnyLQHKQ---LCDVLLIAGNLK-IPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 929654891  828 YTDeAVVIKEsqnvDFICSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18336    79 YTG-VLELKE----DTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSN 121
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 548-650 2.27e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 43.13  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  548 EEFGKLLreadEMDSIHDVTFQVG--NRLFPAHKYILAVHSDFF------------QKLFLSDGNTSEFTDIYQKDEDSa 613
Cdd:cd18308    12 DDFGRLL----ESRQFCDVEFIVGeeEERIPAHIAFVAARSKWLrnkilqarerqkQKAEQEVEDEGSEADSSSASKND- 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 929654891  614 GCHLFV-VEKVHPDMFEYLLQFIYTDTCDFLTHGFKPR 650
Cdd:cd18308    87 SPMLEVrLPEADPEAFELILSFIYTDKIDPTRKGQDPG 124
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 2.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 42.57  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVV-IKESQNvdficsV 847
Cdd:cd18272    34 DVTI-SVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLrVEELQE------T 106

                          90       100
                  ....*....|....*....|....*...
gi 929654891  848 LVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18272   107 YEVADMYQLTALFEECSRFLARTVQVRN 134
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-863 2.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 41.87  E-value: 2.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEasSCAALEMpIHSDI-----LKVILDYLYTDEAVVI 835
Cdd:cd18201    15 QRKKGILCDVNI-VVSGKVFRAHKNILVAGSRFFKTLYCFTNKE--SCDQTTV-THLDVvavqgFSVILDFMYSGNLVLT 90

                          90       100
                  ....*....|....*....|....*...
gi 929654891  836 keSQNVdfiCSVLVVADQLLITRLKEIC 863
Cdd:cd18201    91 --SQNA---IEVMSVASYLQMTEVVQSC 113
PHA02713 PHA02713
hypothetical protein; Provisional
 767-864 2.95e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.00  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWI--EASSCAALEMpIHSDILKVILDYLYTDEAvvikESQNVdfi 844
Cdd:PHA02713   25 LCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIirDLVTRVNLQM-FDKDAVKNIVQYLYNRHI----SSMNV--- 96

                          90       100
                  ....*....|....*....|
gi 929654891  845 CSVLVVADQLLITRLKEICE 864
Cdd:PHA02713   97 IDVLKCADYLLIDDLVTDCE 116
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 553-637 3.21e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 42.29  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  553 LLREADEMDSihDVTFQV-GNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDI-YQKDEdsagchLFVVEKVHPDMFEY 630
Cdd:cd18310    10 LLDSPDLFYS--DAEIIVeGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPkLELRE------LIPGGIVGYDAFML 81


                  ....*..
gi 929654891  631 LLQFIYT 637
Cdd:cd18310    82 VLSYLYS 88
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 777-831 3.23e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 41.16  E-value: 3.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 929654891  777 GKEFPCHKCVLCARLEYFHSMLSSSWIEAS------SCAALEMPIHSDILKvildYLYTDE 831
Cdd:cd18283    11 GTCFPVHRAILSARCPFFRDLLSSSPGYGAeipvdlPTAGIDVPMFSALLR----YLYTGE 67
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 542-637 3.25e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 41.50  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  542 SSSSF--FEEF---GKLLreademdsihDVTFQVGNRLFPAHKYILAVHSDFFQKLFlsdgnTSEFTDIYQKDedsagch 616
Cdd:cd18247     3 PSSGFpvMEEIrrqGKLC----------DVTLKVGDQKFSAHRIVLAATIPYFHAMF-----THDMVESKQDE------- 60

                          90       100
                  ....*....|....*....|.
gi 929654891  617 lFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18247    61 -ITMQGIEPSALEALINFAYS 80
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 3.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 41.76  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  548 EEFGKLLreadEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSD-----GNTSEFTDiyqkdedsagchlfvvek 622
Cdd:cd18345     7 DDLGLLF----ERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEmeerkQNRVEITD------------------ 64

                          90
                  ....*....|....*
gi 929654891  623 VHPDMFEYLLQFIYT 637
Cdd:cd18345    65 VDHEVMREMLRFIYT 79
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 749-834 3.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 41.71  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  749 IAKNTGNKLKL----SQKKCSFlCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSwiEASSCAALEMpIHSDILKVIL 824
Cdd:cd18226     1 SLQYNKNLLKYlnddRQKQSSF-CDLVI-TVEGKEFSAHKVVVAVGSSYFHACLSKN--PNTDAVTLDH-VSYSVFQHLL 75

                          90
                  ....*....|
gi 929654891  825 DYLYTDEAVV 834
Cdd:cd18226    76 EFLYTSEFFV 85
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-863 3.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 41.63  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  765 SFLCDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSSSWIEaSSCAALEMP-IHSDILKVILDYLYTDEAVVIKESQNVdf 843
Cdd:cd18339    19 QLLCDVTIVAED-VEIEAHRVVLAACSPYFCAMFTGDMSE-SKAKKIEIKdVDGQTLSKLIDYIYTAEIEVTEENVQV-- 94

                          90       100
                  ....*....|....*....|
gi 929654891  844 icsVLVVADQLLITRLKEIC 863
Cdd:cd18339    95 ---LLPAASLLQLMDVRQNC 111
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-864 3.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 41.76  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMP--IHSDILKViLDYLYTDEAVvikes 838
Cdd:cd18202    13 QRLNNQFCDVTL-LIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSgfCKSSFLPL-LEFAYTSELT----- 85

                          90       100
                  ....*....|....*....|....*....
gi 929654891  839 qnVDFiCS---VLVVADQLLITRLKEICE 864
Cdd:cd18202    86 --FDF-CSmaeVAMLARHLFMNEVLEICE 111
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 759-800 3.78e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 41.60  E-value: 3.78e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 929654891  759 LSQKKCSFL-------CDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSS 800
Cdd:cd18309     5 LEQDMEAFLesvggdfCDITL-LLDGHPIPAHKAILAARCSYFEAMFRS 52
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-863 5.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 41.28  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  762 KKCSFLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVikESQNV 841
Cdd:cd18249    18 RKHRELCDVVLV-VGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITV--EEGNV 94

                          90       100
                  ....*....|....*....|..
gi 929654891  842 DficSVLVVADQLLITRLKEIC 863
Cdd:cd18249    95 Q---TLLPAACLLQLAEIQEVC 113
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-123 5.25e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.79  E-value: 5.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891   43 NAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSA 122
Cdd:COG0666    45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123


                  .
gi 929654891  123 L 123
Cdd:COG0666   124 L 124
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 5.59e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 41.13  E-value: 5.59e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFlsdgntseftdIYQKDEdsagCHLFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18193    23 DCTVAIGDVYFKAHKSVLASFSNYFKMLF-----------VHQTSE----CVRLKPTDIQPDIFSYLLHLMYT 80
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 565-640 5.66e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 40.69  E-value: 5.66e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFlsdgnTSEFTdiyqkdEDSAGchLFVVEKVHPDMFEYLLQFIYTDTC 640
Cdd:cd18300    11 DVTFIVEDGTIPAHKALLVARCDVMAAMF-----GGNFR------ESSAK--EVELPGVSKETFLALLEYLYTDQA 73
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 6.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 41.14  E-value: 6.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  548 EEFGKLLreadEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDM 627
Cdd:cd18343    10 EDLGNLW----ENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND-------------VDPEV 72

                          90
                  ....*....|
gi 929654891  628 FEYLLQFIYT 637
Cdd:cd18343    73 FKEMMRFIYT 82
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-883 6.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 41.42  E-value: 6.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASScAALEMPIHSDI-LKVILDYLYTDEAVVikESQ 839
Cdd:cd18266    19 QRQRGLFCDVVL-VADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQ-KEVELVGASYIgLKAVIDFLYSSELPL--DGG 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 929654891  840 NVDFicsVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFA 883
Cdd:cd18266    95 NIDY---VLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 7.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 40.91  E-value: 7.05e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagchlfVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18250    23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRV-------------VLHGVSAEILGLLLDFSYT 82
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 7.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 40.93  E-value: 7.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYT 637
Cdd:cd18237    23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD-------------AEPDIIELLVEFAYT 82
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-879 7.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 40.97  E-value: 7.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  775 VDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKEsqNVDFIcsvLVVADQL 854
Cdd:cd18271    31 VKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD--NVEMF---FQMSSFL 105

                          90       100
                  ....*....|....*....|....*
gi 929654891  855 LITRLKEICEVALTEKLTLKNAAML 879
Cdd:cd18271   106 QVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 8.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 40.97  E-value: 8.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedsagchlfVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18340    29 DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREI-------------VLEDVDPDVMGKILHYIYT 88
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-875 8.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 40.73  E-value: 8.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  775 VDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMP---IHSDILKVILDYLYTDEAVVikESQNVDficSVLVVA 851
Cdd:cd18258    24 VEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTmsnINADVLELLLEFVYTGSLII--DSANAK---TLLEAA 98

                          90       100
                  ....*....|....*....|....
gi 929654891  852 DQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18258    99 NKFQFHTFCKVCVSFLEKQLTASN 122
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 8.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 40.94  E-value: 8.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSdgntseftdiYQKDEDSAGCHLFVVEKVHpdmFEYLLQFIYT 637
Cdd:cd18264    30 DVVLEAEGNEFPAHRSLLACSSDYFRALFKD----------YTQESKARVIHLPVVSAAG---LQRVLDFIYT 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 17-128 8.64e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.50  E-value: 8.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891   17 HALDVLSVVTKGSENQIKAFLSSHCynAATIKDVFGRNALHLVSSCG--KKGVLDWLIQKGVDLLVKDK----------- 83
Cdd:PHA03100  108 TPLLYAISKKSNSYSIVEYLLDNGA--NVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAKNRvnyllsygvpi 185

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 929654891   84 ----ESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMK 128
Cdd:PHA03100  186 nikdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-864 9.27e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 40.13  E-value: 9.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  768 CDVTMkSVDGKEFPCHKCVLCARLEYFHSM----LSSSWIEASSCAalempihsDILKVILDYLYTDEAVVIKESqnvdf 843
Cdd:cd18232    19 CDATL-DVGGRVFKAHWSVLACCSHFFQSLygdgTSGSVVLPESFA--------EVFGLLLDFFYTGELALTREN----- 84

                          90       100
                  ....*....|....*....|.
gi 929654891  844 ICSVLVVADQLLITRLKEICE 864
Cdd:cd18232    85 RDRVLLAAKELRVPEAVELCQ 105
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-831 9.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 40.59  E-value: 9.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654891  755 NKLKLSQKkcsfLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKViLDYLYTDE 831
Cdd:cd18224    18 NKCRLSET----MCDVTIV-VGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDFITPANFEKV-LSFIYTSE 88
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 9.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 40.30  E-value: 9.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSdGNTSEFTDIYQKDedsagchlFVVekvhPDMFEYLLQFIYTDT 639
Cdd:cd18326    27 DVVILVEGREFPTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEID--------FVS----AEALTALLDFAYTAT 88
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 1.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 40.71  E-value: 1.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGchlfvvekvhpdmFEYLLQFIYTDTCDF 642
Cdd:cd18244    32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATG-------------FSHVLQFMYYGTIEL 96
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 40.72  E-value: 1.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGntseftdiyqkdEDSAGCHLFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18207    29 DVLLRVGEESFPAHRAVLAACSEYFESVFSAQE------------GDGGTPRELEMHTISSKVFGDILDFAYT 89
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 1.13e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 40.23  E-value: 1.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLsdGNTSEFTDIYQKDEDSagchlfVVEKVHPDM--FEYLLQFIYTDT 639
Cdd:cd18228    21 DVTIRVQDKIFRAHKVVLAACSDFFRSKLV--GQASPRLVLVSPAGKC------VLDLHHVTVtgFAPLLEYAYTST 89
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-864 1.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 39.71  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEA--SSCAALEMpIHSDILKVILDYLYTDEAVVikES 838
Cdd:cd18199    12 QRKQDFFCDCSI-IVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgrPSTASFDV-FSSDAFSIILDFVYSGKLSL--TS 87

                          90       100
                  ....*....|....*....|....*.
gi 929654891  839 QNVdfiCSVLVVADQLLITRLKEICE 864
Cdd:cd18199    88 QNV---IEVMSAASYLQMTDVINVCK 110
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-852 1.59e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 39.78  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIhSDILKVILDYLYTDEAVVI-KESQ 839
Cdd:cd18212    17 QRKKDFLCDITL-IVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLEGMV-AETFGALLEFIYTGCLQVGeKSLE 94

                          90
                  ....*....|...
gi 929654891  840 NVDFICSVLVVAD 852
Cdd:cd18212    95 QILATAQFLKVND 107
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 1.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 39.63  E-value: 1.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFlsdgntseftdIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDT 639
Cdd:cd18245    16 DATLVVGGEEIPVQKNVLAAASPYFRAKL-----------NYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQ 79
BACK_RCBTB1_2 cd18498
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, ...
 871-923 1.62e-03

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors.


Pssm-ID: 350573  Cd Length: 64  Bit Score: 38.03  E-value: 1.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 929654891  871 LTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDL 923
Cdd:cd18498     1 ITVENAAFLYAAAIKYNAKELEEFCFKFAVNHLTAVVQTEAFSKLDESTLKDF 53
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-638 1.71e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 39.73  E-value: 1.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 929654891  565 DVTFQVGN----RLFPAHKYILAVHSDFFQKLFlSDGNTSEFTDIYQKDedsagchlfvvekVHPDMFEYLLQFIYTD 638
Cdd:cd18281    24 DVHFIVGKgdneQRIPAHKFVLSIGSAVFDAMF-NGGMATTSAEIELPD-------------VEPAAFLALLRFLYSD 87
Ank_4 pfam13637
Ankyrin repeats (many copies);
86-124 1.77e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 1.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 929654891    86 GWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALD 124
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALH 39
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 564-642 1.87e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 39.55  E-value: 1.87e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929654891  564 HDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYqkdedsagchlfvVEKVHPDMFEYLLQFIYTDTCDF 642
Cdd:cd18286    18 SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEIT-------------LTGVSHAAVSFVLLFIYGGVLDL 83
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.90e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 39.45  E-value: 1.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQ-KLFLSDGNTseftdiyqkdedsagchLFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18200    20 DLSVHVQGRVFRAHKAVLAASSPYFHdKLLLNDTNC-----------------LVLPSVIEAAAFENLLQLIYS 76
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-864 1.95e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 39.42  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHS-DILKVILDYLYTdeAVVIKESQ 839
Cdd:cd18329    15 QRKQELFCDCSI-LVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSpDTFTIILDFVYS--GKLSLTSQ 91

                          90       100
                  ....*....|....*....|....*
gi 929654891  840 NVdfiCSVLVVADQLLITRLKEICE 864
Cdd:cd18329    92 NV---IEVMSAASYLQMTDVISVCK 113
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 757-867 2.10e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 39.57  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  757 LKLSQKKCS-FLCDVTMkSVDGKEFPCHKCVLCARLEYFHSM-LSSSWIEASScaalEMpIHSDILKVILDYLYTDEAVV 834
Cdd:cd18334    10 LQLNQQRAKgFLCDVII-VVENALFRAHKNILAASSMYFKSLvLHDNLINLDT----DM-VNPTVFRQILDFIYTGKLLT 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654891  835 IKESQNVDFiCSVLVVADQLLITRLKEICEVAL 867
Cdd:cd18334    84 SDQPGEQNF-NALLTAASYLQLHDLAALCRKKL 115
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-864 2.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 39.14  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMlsssWIEASSCaalempIHSDI-----LKVILDYLYTdeavvI 835
Cdd:cd18206    16 QRQLGLLCDCTF-VVDGVDFKAHKAVLAACSEYFRML----FVDQKDV------VHLDIsnaagLGQVLEFMYT-----A 79

                          90       100
                  ....*....|....*....|....*....
gi 929654891  836 KESQNVDFICSVLVVADQLLITRLKEICE 864
Cdd:cd18206    80 KLSLSPENVDDVLAVATFLQMQDIVTACH 108
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-636 2.17e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 39.83  E-value: 2.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLsdgNTSEftdiyqkdEDSAGCHLFVVEKVHPDMFEYLLQFIY 636
Cdd:cd18350    26 DVTFLVEGKLFYAHKVLLVTASNRFKSLLT---NKSE--------QESQGSKTIEISDIKYHIFQMLMQYLY 86
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 2.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 39.43  E-value: 2.31e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTdiyqkdedsagchLFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18253    20 DVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREM-------------LVEINGILAEAMDCFLQYVYT 79
Ank_5 pfam13857
Ankyrin repeats (many copies);
40-91 2.48e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 2.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 929654891    40 HCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKEsGWTALH 91
Cdd:pfam13857    4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEE-GLTALD 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 86-117 2.71e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 2.71e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 929654891    86 GWTALHRSI-FYGHIDCVWSLLKHGVSLYIQDK 117
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-794 2.71e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 39.16  E-value: 2.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYF 794
Cdd:cd18278    25 QRKQDILCDVTL-IVEGKEFRAHRAVLAACSEYF 57
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-867 3.04e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 38.77  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDvTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSwiEASSCAALEMpIHSDILKVILDYLYTDEAVVIKESqnvdfICS 846
Cdd:cd18218    18 LCD-TLITVGSQEFPAHSLVLAGASQQLGRQLTNP--NPGQWCLGEG-ISPSTFKQLLDFVYGESVEVQPGE-----LRP 88

                          90       100
                  ....*....|....*....|.
gi 929654891  847 VLVVADQLLITRLKEICEVAL 867
Cdd:cd18218    89 LLEAARALEVESLEEACWRAL 109
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-864 3.25e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 38.77  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  775 VDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHsdilKVILDYLYTDEAVVIKEsqnvDFIcSVLVVADQL 854
Cdd:cd18354    27 VDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVY----RAFLEYLYTDSISLSPE----DAI-GLLDLATFY 97

                          90
                  ....*....|
gi 929654891  855 LITRLKEICE 864
Cdd:cd18354    98 RENRLKKLCQ 107
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-838 3.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 38.70  E-value: 3.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMpIHSDILKVILDYLYTDEAVVIKES 838
Cdd:cd18209    18 LCDVLL-IVGDQKFRAHKNVLAASSEYFQSLFTEKENESQSVFQLDF-CEPDAFENVLNYIYSSSLFVEKSS 87
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 562-645 4.17e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 38.61  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  562 SIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFlsDGNTSEftdiyqKDEDSAGchlfvVEKVHPDMFEYLLQFIYTDTCD 641
Cdd:cd18352    12 TLSDVTFLVEGRRFYAHRIALLASSDAFRAMF--DGGYRE------KEARDIE-----IPNIRWEVFELMMRFIYTGSVD 78


                  ....
gi 929654891  642 FLTH 645
Cdd:cd18352    79 ITND 82
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 552-637 4.23e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 38.10  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  552 KLLREadEMDSihDVTFQVGNRLFPAHKYIL-AVHSDFFQKLFlsdGNTSEFTDIYqkdedsagchLFVVEKVHPDMFEY 630
Cdd:cd18285     8 RLLRE--ELHT--DVTFYVGSTLFKAHKAILlARVPEFFSHII---GKLSSLEDQE----------PINIENLEASEFKT 70


                  ....*..
gi 929654891  631 LLQFIYT 637
Cdd:cd18285    71 FLRQVYT 77
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-834 4.38e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 38.86  E-value: 4.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929654891  766 FLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVV 834
Cdd:cd18246    38 LLCDIVLH-VGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVV 105
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 754-875 4.67e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 38.67  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  754 GNKLKLSQKKcsfLCDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEav 833
Cdd:cd18341    17 GLKELLDENK---FVDCTLKAGD-KSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAE-- 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 929654891  834 VIKESQNVDFIcsvLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18341    91 IDLNDGNVQDI---FALASRFQIPSVFTVCVTYLQKRLSPAN 129
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-864 4.69e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 38.36  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKSVDGKE-FPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMpIHSDILKVILDYLYTDEAVVikESQNVDfic 845
Cdd:cd18231    14 LCDVDIVLVRQRStFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEA-LTSQGLQQILNFIYTSKLLV--NSCNVQ--- 87

                          90
                  ....*....|....*....
gi 929654891  846 SVLVVADQLLITRLKEICE 864
Cdd:cd18231    88 DVLNAAAVLQMNDIAASCQ 106
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 565-646 4.69e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 37.70  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNtseftdiyqkdedsAGCHLFV---VEKVHPDMFEYLLQFIYTDtcD 641
Cdd:cd18283     4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPG--------------YGAEIPVdlpTAGIDVPMFSALLRYLYTG--E 67


                  ....*
gi 929654891  642 FLTHG 646
Cdd:cd18283    68 FGSED 72
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 766-829 4.71e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 38.83  E-value: 4.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 929654891  766 FLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAA-LEMP-------IHSDILKVILDYLYT 829
Cdd:cd18310    17 FYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPkLELRelipggiVGYDAFMLVLSYLYS 88
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 5.64e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 38.31  E-value: 5.64e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNtseftdiyqkdedSAGCHLFVVEKVHPDMFEYLLQFIYTDT 639
Cdd:cd18198    27 DVVILVQGREYRTHRSVLAACSQYFKKLFTSGAV-------------VDQQNVYEIDFVSPEALTALLEFAYTAT 88
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 6.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 38.49  E-value: 6.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYqkdedsagchlfvVEKVHPDMFEYLLQFIYT 637
Cdd:cd18336    21 DVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIK-------------MEGVDPDALKALVHYAYT 80
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-863 6.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 37.45  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSSswiEASSCAALEMP--IHSDILKVILDYLYTDEAVVIKEsqNVDFI 844
Cdd:cd18955     1 LCDVTI-VVEDQRFRAHRAVLAACSDYFLSRVVG---QTDGDLVITLPeeVTVKGFEPLLQFAYTAKLLLSKE--NVLEV 74

                          90
                  ....*....|....*....
gi 929654891  845 CSvlvVADQLLITRLKEIC 863
Cdd:cd18955    75 CR---CAEFLGVHNIEKAC 90
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 6.51e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 38.34  E-value: 6.51e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYT 637
Cdd:cd18195    20 DVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQSPERVLELPGVKAGVFSDVLNFIYS 92
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-846 7.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 37.92  E-value: 7.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIeASSCAALEMP-IHSDILKVILDYLYTdeAVVIKESQ 839
Cdd:cd18198    19 QRTQGLLCDVVIL-VQGREYRTHRSVLAACSQYFKKLFTSGAV-VDQQNVYEIDfVSPEALTALLEFAYT--ATLTVSTA 94


                  ....*..
gi 929654891  840 NVDFICS 846
Cdd:cd18198    95 NVGDILS 101
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-863 7.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 38.12  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  761 QKKCSFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSMlsssWIEASSCAALEMPIHSDIL-----KVILDYLYTdeAVVI 835
Cdd:cd18230    15 QRQHGILCDVCI-IVEGKIFKAHKNVLLGSSRYFKTL----YCQVQKTSDQATVTHLDIVtaqgfKAIIDFMYS--AHLA 87

                          90       100
                  ....*....|....*....|....*...
gi 929654891  836 KESQNVdfiCSVLVVADQLLITRLKEIC 863
Cdd:cd18230    88 LTSKNV---IEVMSAASYLQMTDIVQAC 112
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 8.77e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 37.76  E-value: 8.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654891  565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGchlfvvekvhpdmFEYLLQFIYT 637
Cdd:cd18255    20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKG-------------LKHILDFAYT 79
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-875 8.77e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 37.87  E-value: 8.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  765 SFLCDVTMkSVDGKEFPCHKCVLCARLEYFHSML----SSSWIEASSCAALEmpihsdiLKVILDYLYTDeavviKESQN 840
Cdd:cd18260    16 RFLCDLTI-ATKTKSFDVHKVVMASCSEYFRNILkkdpSLQRVELNDISPLG-------LATVITYAYTG-----KLTLS 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 929654891  841 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKN 875
Cdd:cd18260    83 LYTIGSTISAASYLQIHALVKMCCDFLMQEMNVEN 117
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-651 8.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 37.53  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  554 LREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTdiyqkdedsagchLFVVEKVHPDMFEYLLQ 633
Cdd:cd18332    10 LNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSV-------------LTLPSGLEARGFQLLLD 76

                          90
                  ....*....|....*...
gi 929654891  634 FIYTdTCDFLTHGFKPRI 651
Cdd:cd18332    77 FMYT-SRLPLTPRTVPAV 93
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-864 9.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 37.52  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKEsqNVDficS 846
Cdd:cd18257    18 LCDVVLR-VGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQA--TVE---S 91

                          90
                  ....*....|....*....
gi 929654891  847 VLVVADQLLITR-LKEICE 864
Cdd:cd18257    92 LLPAANLLQIKLvLKECCD 110
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-639 9.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 37.90  E-value: 9.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654891  554 LREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIyqkdedSAGCHLFVVEKVHPDMFEYLLQ 633
Cdd:cd18327    16 LNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA------GGGQDVCELDFVGPEALGALLE 89


                  ....*.
gi 929654891  634 FIYTDT 639
Cdd:cd18327    90 FAYTAT 95
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-831 9.95e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 37.53  E-value: 9.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 929654891  767 LCDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKV-------ILDYLYTDE 831
Cdd:cd18228    19 FCDVTIR-VQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGKCVLDLHHVtvtgfapLLEYAYTST 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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