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Conserved domains on  [gi|6097863|dbj|BAA85747|]
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GD1 alpha synthase [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 78-321 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467704  Cd Length: 244  Bit Score: 523.66  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   78 GYLGVADHKPLKMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHD 157
Cdd:cd23976   1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  158 LLNVSQGTVFIFWGPSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTM 237
Cdd:cd23976  81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  238 TIALELCDRIDVYGMVPPDFCRDPKHPSVPYHYYEPSGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQP 317
Cdd:cd23976 161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                ....
gi 6097863  318 DWKP 321
Cdd:cd23976 241 DWKP 244
 
Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 78-321 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 523.66  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   78 GYLGVADHKPLKMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHD 157
Cdd:cd23976   1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  158 LLNVSQGTVFIFWGPSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTM 237
Cdd:cd23976  81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  238 TIALELCDRIDVYGMVPPDFCRDPKHPSVPYHYYEPSGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQP 317
Cdd:cd23976 161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                ....
gi 6097863  318 DWKP 321
Cdd:cd23976 241 DWKP 244
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 89-308 9.51e-30

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 114.24  E-value: 9.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863     89 KMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVI-AHSSIQRILRNRHDLLNVSQGTVF 167
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863    168 IFwgpsSYMrrdgKGQAYnnlqLLsqvlprLKAFMITRH-----RMLQFDELFKQETGKD----------RKISNTWL-- 230
Cdd:pfam00777 120 VL----VPF----KGRDL----LW------LPAFLTKGNvsrslRVLYTLKEVKIPVDPDkvlflhpdflRYVANFWLrs 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863    231 --------STGWFTMTIALELCDRIDVYGMVPPDfcrdpKHPSVPYHYYEpsgpdectmYLSHERGRKGSHHRFITEKRV 302
Cdd:pfam00777 182 hglkgrrpSTGLLMLSLALHLCDEVSLYGFGPFL-----DSRGNSHHYYD---------NVLMKKGGFYGVHDMPFEFKL 247


                  ....*.
gi 6097863    303 FKNWAR 308
Cdd:pfam00777 248 LQKLHK 253
 
Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 78-321 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 523.66  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   78 GYLGVADHKPLKMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHD 157
Cdd:cd23976   1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  158 LLNVSQGTVFIFWGPSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTM 237
Cdd:cd23976  81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  238 TIALELCDRIDVYGMVPPDFCRDPKHPSVPYHYYEPSGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQP 317
Cdd:cd23976 161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                ....
gi 6097863  318 DWKP 321
Cdd:cd23976 241 DWKP 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 92-317 1.19e-132

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 376.97  E-value: 1.19e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLL-NVSQGTVFIFW 170
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAILLLaGTRAPTVVVFW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  171 GPSSYMRRDGKGQaYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRIDVY 250
Cdd:cd23965  81 GPETKMNKDGAGK-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6097863  251 GMVPPDFCRDPKHPSVPYHYYEPSGPDECTMYLSHERGRKGsHHRFITEKRVFKNWARTFNIHFFQP 317
Cdd:cd23965 160 GMVPENYCREHPNSKVPYHYYEPGGLKECTYYNYHENALKG-GHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 92-319 4.47e-124

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 355.32  E-value: 4.47e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWG 171
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  172 PSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRIDVYG 251
Cdd:cd23978  81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6097863  252 MVPPDFCRD-PKHPSVPYHYYEPSGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDW 319
Cdd:cd23978 161 MVPPNYCSKrPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 92-319 1.01e-97

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 288.30  E-value: 1.01e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWG 171
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  172 PSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRIDVYG 251
Cdd:cd23977  81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6097863  252 MVPPDFCRDPKHPSVPYHYYEPSGPDECTMYLSHERGRKGShHRFITEKRVFKNWARTFNIHFFQPDW 319
Cdd:cd23977 161 MVSDSYCRNKNHSSVPYHYYEKGRLDECRMYLVHERAPRGG-HRFITEKAIFSRWAKRKKIRFAHPSW 227
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 92-319 5.78e-82

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 248.31  E-value: 5.78e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWG 171
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  172 PSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRIDVYG 251
Cdd:cd23975  81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6097863  252 MVPPDFCRDPKHPSVPYHYYEPsGPDECTMYLSHERGRKGShHRFITEKRVFKNWARTFNIHFFQPDW 319
Cdd:cd23975 161 MINDTYCKTEGYRKVPYHYYEP-GRDECDEYFLHENAPYGG-HRFITEKKVFAKWAKKHPITFTHPNW 226
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 95-306 4.02e-42

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 144.81  E-value: 4.02e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   95 CALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLNVS---QGTVFIFWG 171
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLpleEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  172 PSSYMRRDGKGQA--YNNLQLLsqVLPRLKAFMITRHRMLQFdELFKQETGKDRKisntwlSTGWFTMTIALELCDRIDV 249
Cdd:cd19952  81 AAAADFKRLKRRKkrHDNAVLL--LTDPAPDLLSYVRKRLEK-LGLKSFFGGNAP------SSGLLAVLLALQLCDSVDL 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6097863  250 YGmvppdFCRDP-KHPSVPYHYYEPSGPdectmylsherGRKGSHHRFITEKRVFKNW 306
Cdd:cd19952 152 YG-----FGVDSgHAPKVPYHYYDLVEA-----------EEGTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 89-308 9.51e-30

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 114.24  E-value: 9.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863     89 KMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVI-AHSSIQRILRNRHDLLNVSQGTVF 167
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863    168 IFwgpsSYMrrdgKGQAYnnlqLLsqvlprLKAFMITRH-----RMLQFDELFKQETGKD----------RKISNTWL-- 230
Cdd:pfam00777 120 VL----VPF----KGRDL----LW------LPAFLTKGNvsrslRVLYTLKEVKIPVDPDkvlflhpdflRYVANFWLrs 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863    231 --------STGWFTMTIALELCDRIDVYGMVPPDfcrdpKHPSVPYHYYEpsgpdectmYLSHERGRKGSHHRFITEKRV 302
Cdd:pfam00777 182 hglkgrrpSTGLLMLSLALHLCDEVSLYGFGPFL-----DSRGNSHHYYD---------NVLMKKGGFYGVHDMPFEFKL 247


                  ....*.
gi 6097863    303 FKNWAR 308
Cdd:pfam00777 248 LQKLHK 253
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 95-299 1.54e-27

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 108.50  E-value: 1.54e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   95 CALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRI---LRNRHDL------LNVSQGT 165
Cdd:cd23963  66 CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRynsLKKNRDRdkflnrLKEYNGS 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  166 VFIFWGPSSYMRRDgkgQAYNNLQLLSQVLPRLK-AFMITRHRMLQFDelFKQETGKDRkisntWLSTGWFTMTIALELC 244
Cdd:cd23963 146 ILWYPKFSFKSSTN---LLLKAARALKKNGLNLTvVYSNPEHFLAVQK--FWKRRGLEK-----RPSTGLYLVSLALTFC 215

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6097863  245 DRIDVYGMVPpdFCRDPKHPSVPYHYYEPSGPDEctmylshergrKGSHHRFITE 299
Cdd:cd23963 216 DEIHLYGFWP--FPTDPNGRPVPYHYYDDLSPST-----------KNKVHNMPEE 257
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 57-305 3.46e-26

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 104.66  E-value: 3.46e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   57 QLVESSPQPRRTAPAGPRQLEGYLGVADHKPLKMHCKD---CALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLD 133
Cdd:cd23968   7 RLKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRyntCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKD 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  134 VGNRTSLRVIAHssiQRILRNRHDLLNVS---QGTVFIfWGPSSY-------MRRDGKGqAYNNLQLLSQVLPRLKAFMI 203
Cdd:cd23968  87 VGSKTTLRLINS---QILSKPEFNFLTDPlyrNVTLLV-WDPSSYnvnlekwYKKPDFD-FFPNYIKYRRRHPEEPFYLI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  204 TRHRMLQF-DELfkqETGKDRKISNTWLSTGWFTMTIALELCDRIDVYGMVPP----DFCrdpkhpsvpyHYYEPSGPDE 278
Cdd:cd23968 162 DPRFLWRLwDIL---QEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSvrqtDRC----------HYYDVEKDLA 228

                       250       260
                ....*....|....*....|....*..
gi 6097863  279 CTMylshergrkGSHHRFITEKRVFKN 305
Cdd:cd23968 229 CTL---------GAWHPLAAEKLLVRH 246
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 92-304 7.22e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 96.98  E-value: 7.22e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVI-AHSSIQRILRN------------RHD- 157
Cdd:cd23967   2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFyPESAFRDPEEYdsdwllvlvpfkSMDl 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  158 --LLNVSQG---TVFIFWGPSSYMRRDGKGqayNNLQLLSQVLPRLKAFMItrhrmlqfdeLFKQETGKDRKIsntWLST 232
Cdd:cd23967  82 lwLQAVIKGkkpNGKGGFWKKIATSVPKPP---KKIRILNPYILQEAAFDL----------IGLPMNGKQGKN---VPTT 145

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6097863  233 GWFTMTIALELCDRIDVYGmvppdFCRDPKHPSVPYHYYEPSgpdecTMYLShergRKGSHHRFITEKRVFK 304
Cdd:cd23967 146 GIIAIVMALHYCDEVDIAG-----FGYDPSDPNAPLHYYDSL-----TMKAI----KRSWTHNVTKEKKYLK 203
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 87-272 6.21e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 88.07  E-value: 6.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   87 PLK-MHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRnrhDLLNVSQGT 165
Cdd:cd23987  58 PLKnKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFE---DLVNETWKE 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  166 VF----------IFWGPsSYMRRDGKGQA--YNNLQLLSQV-----LPRLKAFMITRHRMLQFDELFKQETgkdrkisnt 228
Cdd:cd23987 135 KFlqrlqslngsILWIP-AFMAKGGEERVewVNDLILKHHInvrtaYPSLRLLHAVRGYWLTNKVHIKRPT--------- 204

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6097863  229 wlsTGWFTMTIALELCDRIDVYGMVPpdFCRDPKHPSVPYHYYE 272
Cdd:cd23987 205 ---TGLLMYTLATRFCNRIHLYGFWP--FPRDQNQNPVKYHYYD 243
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 88-275 6.11e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 85.14  E-value: 6.11e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   88 LKMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNrhdLLNVSQGTVF 167
Cdd:cd23970  64 QNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNN---LLTIQDRNNF 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  168 ifwgpssymrrdgkgqaYNNLQLLSQVLPRLKAFM----ITRHRMLQ--FDELFKQ----------------ETGKDRKI 225
Cdd:cd23970 141 -----------------FLSLKKLDGAILWIPAFFfhtsATVTRTLVdfFVEHRGQlkvqlawpgnimqhvnRYWKTKHL 203

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6097863  226 SNTWLSTGWFTMTIALELCDRIDVYGMVPpdFCRDPKHPSVPYHYYEPSG 275
Cdd:cd23970 204 SPKRLSTGILMYTLASAICEEIHLYGFWP--FGFDPTGTPLPYHYYDKKG 251
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 87-304 1.29e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 81.31  E-value: 1.29e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   87 PLK-MHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSL-----RVIAH-------SSIQRILR 153
Cdd:cd23969  58 PLKgKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLttmnpSVIPHaygdlvnATDKEKFV 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  154 NRHDLLNVSqgtvfIFWGPSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITrhRMLQfdelfkqetgkdrKISNTWL--- 230
Cdd:cd23969 138 ERLRQLGDS-----ILWIPAFVSKGGEEHVQWTNEIILKHKLNVKTAYPPL--RLNH-------------AIRGYWLttk 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  231 ------STGWFTMTIALELCDRIDVYGMVPpdFCRDPKHPSVPYHYYEPSGpdectmYLShergrKGSHHRFITEKRVFK 304
Cdd:cd23969 198 frikrpSTGLLMYTLATRFCDEIHLYGFYP--FSEDGNGRAVKYHYYDNRK------YLT-----TARPHKMPEEFRALR 264
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 93-300 2.13e-17

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 80.65  E-value: 2.13e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   93 KDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAhssiQRILRN-RHDLLNVS--QGTVFIF 169
Cdd:cd23986  50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN----SQILTNpNHHFIDSSlyKDVILVA 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  170 WGPSSYmrrdgkgqAYNNLQLLSQvlPRLKAFM-ITRHRMLQFDELFK--------------QETGKDrKISNTWLSTGW 234
Cdd:cd23986 126 WDPAPY--------SANLHKWYKK--PDYNLFTpYVQYRKRNPNQPFYilhpkfiwqlwdiiQENTQE-KIQPNPPSSGF 194

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  235 FTMTIALELCDRIDVYGMVPP----DFCrdpkhpsvpyHYYEPSGPDECTMylshergrkGSHHRFITEK 300
Cdd:cd23986 195 IGILIMMSMCREVHVYEYIPSvrqtDLC----------HYHERYYDAACTL---------GAYHPLLYEK 245
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 93-276 2.82e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 80.38  E-value: 2.82e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   93 KDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTrGYGLDVGNRTSLrVIAHSSiqrILRNRHDLLNvsqgtvfifWGP 172
Cdd:cd23971  65 KTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNL-VTANPS---ILREKFHNLK---------KRR 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  173 SSYMRRdgkGQAYNNLQLLsqvLPrlkAFMITRHRMLQFDELFK-QETGKD-----------RKISNTW---------LS 231
Cdd:cd23971 131 RPFVER---MKVYGNALLL---LP---AFSYTSNTEPSLRALYTlEDFGSPqkvlffnpeylRNLSRYWkskglkarrLS 201

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6097863  232 TGWFTMTIALELCDRIDVYGMVPpdFCRDPKHPSVPYHYYEPSGP 276
Cdd:cd23971 202 TGLMLVSAALELCENVHLYGFWP--FSTDLDGNPISHHYYDNVLP 244
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 91-304 3.71e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 77.05  E-value: 3.71e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   91 HCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIahsSIQRILRNRHDLLNVS--QGTVFI 168
Cdd:cd23985  44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI---NSQLVTTEKHKFLKDSlyNEGILI 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  169 FWGPSSY--------MRRDGKgqAYNNLQLLSQVLPRlKAFMITRHRM-LQFDELFKQETGKDrkISNTWLSTGWFTMTI 239
Cdd:cd23985 121 VWDPAPYhsdipewyKNPDYN--FFENYKTYRRLNPN-QPFYILHPQMqWELWDIIQENSPEE--IQPNPPSSGMLGIIL 195

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6097863  240 ALELCDRIDVYGMVPP----DFCrdpkhpsvpyHYYEPSGPDECTMylshergrkGSHHRFITEKRVFK 304
Cdd:cd23985 196 MMTLCDQVDVYEFLPSkrktDVC----------HYYQKFFDRACTM---------GAYHPLLYEKNLVK 245
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 91-272 1.42e-15

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 74.39  E-value: 1.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   91 HCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVI----AHSSIQRILRNR----------- 155
Cdd:cd23983   1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegAPKSEQEYDPTSlfvavlfksvd 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  156 -HDLLNVSQGTVFIFWGPSSYMRRDGKGQAYN--NLQLLSQVLPRLKAFMItrhrmLQFDELFKQETGKDRKISntwlST 232
Cdd:cd23983  81 fAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKpsQFRILNPLIIKETALDI-----LQYPEPQSRLWGWDKNVP----TL 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6097863  233 GWFTMTIALELCDRIDVYGmvppdFCRDPKHPSVPYHYYE 272
Cdd:cd23983 152 GVTAVVLATHLCDEVSLAG-----FGYDLSQPHAPLHYYD 186
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 93-272 1.08e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 73.06  E-value: 1.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   93 KDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRI---LRNRHDLLN----VSQGT 165
Cdd:cd23988  65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNESDREKfvhrLSMLN 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  166 VFIFWGPsSYMRRDGKGQA--YNNLQLLSQV-----LPRLKAFMITRHRMLQfdelfkqetgkdRKISNTWLSTGWFTMT 238
Cdd:cd23988 145 DSVLWIP-AFMVKGGEKHVewVNALILKNKLkvrtaYPSLRLIHAVRGYWLT------------NKVNIKRPSTGLLMYT 211

                       170       180       190
                ....*....|....*....|....*....|....
gi 6097863  239 IALELCDRIDVYGMVPpdFCRDPKHPSVPYHYYE 272
Cdd:cd23988 212 LATRFCDEIHLYGFWP--FPKDANGNPVKYHYYD 243
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 87-277 2.70e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 71.79  E-value: 2.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   87 PLKMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAP-TRGYGLDVGNRTSLrVIAHSSI-----QRILRNRHDLLN 160
Cdd:cd23989  58 PLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQL-VTANPSIidkrfQNLLWSRKSFVE 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  161 VSQ--GTVFIFWgPSSYMRRdGKGQAYNNLQLLSQVlprlkafmITRHRMLQFDELFKQETG---KDRKISNTWLSTGWF 235
Cdd:cd23989 137 SMKvyGRSYIYM-PAFSMKT-GTDPSLRVYYTLADV--------GANQTVLFANPNFLRNVGkfwKSKGVHAKRLSTGLF 206

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6097863  236 TMTIALELCDRIDVYGMVPpdFCRDPKHPSVPYHYYEPSGPD 277
Cdd:cd23989 207 LVSAALGLCEEVTIYGFWP--FSVDLDERTISHHYYDNVLPD 246
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 91-316 3.51e-14

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 71.54  E-value: 3.51e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   91 HCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLnVSQGTVFIFW 170
Cdd:cd23966  76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVL-VPFKVLDLQW 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  171 GPSS---------YMRrdgkgqaynnlqllsqVLPRLKAfmiTRHRMLQFD-ELFKQetgkdrkISNTWL-------STG 233
Cdd:cd23966 155 LISAlttgeitrtYTP----------------VKRFIKA---DKDKVLVINpAFIKY-------VHDNWTehhgrypSTG 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  234 WFTMTIALELCDRIDVYGmvppdFCRDPK---HpsvpyHYYEPSgpdectmyLSHERGRKGSHHRFITEKRVFKNWARTF 310
Cdd:cd23966 209 FLALIFALHICDEVSVFG-----FGADSKgnwH-----HYWEKN--------RSAGAFRKTGVHDADFESDIIKKLAKEG 270


                ....*.
gi 6097863  311 NIHFFQ 316
Cdd:cd23966 271 KIRVYR 276
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 92-304 1.23e-12

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 65.84  E-value: 1.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVI----AHSSIQriLRNRHDLLnvsqgTVF 167
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypesAQFDPG--IENDPDTL-----LVL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  168 IFWGPSS--YMRRDGKGQAYNNLQLLSQVlPRLKAFMITRHRMLqfDELFKQETGkdRKISNTWL--------STGWFTM 237
Cdd:cd23982  75 VPFKPLDfyWLYEILSNEKRVRKGFWKQP-PRIWDANPKQIRIL--NPYYTYVAA--TKLLQVPGqrkkkqkpTTGLLAI 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6097863  238 TIALELCDRIDVYGMVPPdfcrDPKHPSVPYHYYEPSgpdecTMylsheRGRKGSHHRFITEKRVFK 304
Cdd:cd23982 150 TLALHLCDEVHIAGFGYP----DNGNSNQPIHYYNQI-----TL-----KSMANSGHNLNAEAQAIQ 202
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 83-304 6.20e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 65.54  E-value: 6.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   83 ADHKPLKMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRV-IAHSSIQ--RILRNRhDLL 159
Cdd:cd23973  74 ALSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVhTAHSITSslMILQKR-GFK 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  160 NVSQGT----VFIFWGPssymrRDgkgqaYNNLQ--LLSQVLPRlkAFMITRHRMLQFDELFKQET-------------- 219
Cdd:cd23973 153 NIPQDKdikyILFPEGP-----RD-----YQWLEalLKNKTIPS--GAYYGRRPRSYFSGDFTEDKylvlhpdflryvkn 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  220 ----GKDRKISNTWL---STGWFTMTIALELCDRIDVYGMVPPDfcrdpkHPSVPYHYYEpsgpdectmyLSHERGRKGS 292
Cdd:cd23973 221 rflrSKTLKGKYWAIyrpTTGAFLLLTALHLCDTVSAYGFITED------YRKYPDHYYD----------KKKTKLVFYI 284

                       250
                ....*....|..
gi 6097863  293 HHRFITEKRVFK 304
Cdd:cd23973 285 NHDFRLEKKLWK 296
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 92-272 7.88e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 64.97  E-value: 7.88e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVI-AHSSIQRILRNrhdlLNVSQGTVFIFW 170
Cdd:cd23964  82 CIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFfPESLHNSLLKH----VPQDKDTKYLFI 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  171 gPSS-----YMRRDGKGQAYNNLQLLSQVLPRLKAFMITRH--RMLQFDELfkqetgkdRKISNTWL--------STGWF 235
Cdd:cd23964 158 -PFKirdydYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATnvRLLHPDFI--------RYLFNRWLnsstsyrpTTGAL 228

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6097863  236 TMTIALELCDRIDVYGmvppdFCRDPKHPSvpyHYYE 272
Cdd:cd23964 229 MLLTALHTCDQVSVYG-----FGYDPRFSL---HYYD 257
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 92-272 1.50e-11

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 63.02  E-value: 1.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVI-AHSSIQRILRNRHDLLNVSQGTVFIFW 170
Cdd:cd23981   2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITyPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  171 GPSSYMRRDGKGQAYNNL-QLLSQVLPRlkafmiTRHRMLQFDELFKQETGKD---RKISNTWL------STGWFTMTIA 240
Cdd:cd23981  82 KWLKYIVYKEKVSASDGFwKSVATRVPR------EPHEIRILNPYFIQEAAFSfigLPFNNGLMgrgnipTLGSVAITMA 155

                       170       180       190
                ....*....|....*....|....*....|..
gi 6097863  241 LELCDRIDVYGmvppdFCRDPKHPSVPYHYYE 272
Cdd:cd23981 156 LHNCDEVAVAG-----FGYDMNTPNAPLHYYE 182
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 92-272 5.12e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 62.21  E-value: 5.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLnVSQGTVFIFWG 171
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMIL-VPFKTLDLEWV 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  172 PSsymrrdgkgqAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKqetgkdRKISNTWL-------STGWFTMTIALELC 244
Cdd:cd23980 160 IS----------ATTTGTISHTYVPVPRKIKVKKEKILIYHPAFI------KYVFDRWLqghgrypSTGILSVIFSLHVC 223

                       170       180
                ....*....|....*....|....*...
gi 6097863  245 DRIDVYGmvppdFCRDPKHPSvpYHYYE 272
Cdd:cd23980 224 DEVDLYG-----FGADSKGNW--HHYWE 244
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 92-272 2.49e-10

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 59.37  E-value: 2.49e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSI-------------------QRIL 152
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIfsdpshydpnttvvlipfkPHDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  153 RNRHDLLNVSQGTVFIFWgpssymRRDGKGQAYNNLQLlsQVL-PRLkaFMITRHRMLQFDELFKQEtgkDRKISNTwls 231
Cdd:cd23984  82 RWLLDLLMGKKVSAKGFW------KKPALNLIYKPNQI--RILnPFI--LRIAAYELLHFPKRFPKE---KKPKHPT--- 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6097863  232 TGWFTMTIALELCDRIDVYGmvppdFCRDPKHPSVPYHYYE 272
Cdd:cd23984 146 TGIIAITLALHICNEVHIAG-----FKYDFSNLNSTLHYYG 181
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 91-251 4.44e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 59.50  E-value: 4.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   91 HCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRH---------DLL-- 159
Cdd:cd23979  79 RCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSfvlvpfktlDLLwi 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  160 --NVSQGTVFIFWGP-SSYMRRDG-KGQAYNnlqllsqvlprlKAFmitrhrmlqfdelFKQETGKDRKISNTWLSTGWF 235
Cdd:cd23979 159 tsALSTGQIRFTYAPvKQFLRVDKdKVQIYN------------PAF-------------FKYIHDRWTEHHGRYPSTGML 213

                       170
                ....*....|....*.
gi 6097863  236 TMTIALELCDRIDVYG 251
Cdd:cd23979 214 VLFFALHVCDEVNVYG 229
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 93-272 5.48e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 59.38  E-value: 5.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   93 KDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRG-YGLDVGNRTSLrVIAHSSI-----QRILRNRHDLLNVSQ--G 164
Cdd:cd23991  65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-VTANPSIisikyAKLNERRKPFLETVSvyG 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  165 TVFIFWgPSSYMRRdgkgqaynNLQLLSQVLPRLKAFMiTRHRMLQFDELFKQETG---KDRKISNTWLSTGWFTMTIAL 241
Cdd:cd23991 144 DAFLLL-PAFSYRS--------NTALSFKVYYTLEDFK-AKQKVIFFHPIYLKHLAqfwRSKGVQVYRLSTGLMITSAAL 213

                       170       180       190
                ....*....|....*....|....*....|.
gi 6097863  242 ELCDRIDVYGMVPpdFCRDPKHPSVPYHYYE 272
Cdd:cd23991 214 ELCEEVKLYGFWP--FSKNTEGKPISHHYYD 242
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 92-274 1.26e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 49.37  E-value: 1.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDL----LNVSQGTVF 167
Cdd:cd23974  84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVgfngPPQSKETRY 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  168 IFW---------------------------GPSSYMRRDGKGQAYNNLQllsqvlPRLKAFMitRHRMLQFDELfkqeTG 220
Cdd:cd23974 164 IFLpdhdrdyllvkaalthtpidrgrdkskRPSKYFGKDVTAEKFKIYH------PDFIRYL--RNRFLWSPIL----NT 231

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 6097863  221 KDRKISNTwlSTGWFTMTIALELCDRIDVYGMVPPDFCRDPKhpsvpyHYYEPS 274
Cdd:cd23974 232 KQRDIYRP--STGAVMLLAALHTCDQVSAYGFMTPDYGKYSD------HYYDKT 277
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 92-273 1.75e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 49.05  E-value: 1.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   92 CKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQR--ILRNRHDLLNVSQGT---- 165
Cdd:cd23972  82 CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNslISYWNLGFTRTPQGQdlqy 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  166 VFIfwgPSS----YMRRDG-----------KG---QAYNNLQLLSQVLPRLKAFMI--TRHRMLQfDELFKQETGkdrki 225
Cdd:cd23972 162 IFI---PSDirdyVMLRSAilgvpvpegldKGdrpHKYFGPEASAKKFKLLHPDFIsyLTDRFLK-SKLLNTHYG----- 232

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 6097863  226 SNTWLSTGWFTMTIALELCDRIDVYGMVPPDFCRdpkhpsVPYHYYEP 273
Cdd:cd23972 233 HLYMPSTGALMLLTALHTCDQVSAYGFITSNYWK------FSDHYYER 274
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 93-276 1.86e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 42.52  E-value: 1.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863   93 KDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAP-TRGYGLDVGNRTSLRVIAHSSI----QRILRNRHDLLNVSQGtvf 167
Cdd:cd23990  65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIIterfHKLEKWRRPFYEVLQV--- 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6097863  168 ifwgpssymrrdgkgqaYNNlqlLSQVLPrlkAFMITRHRMLQF------DELFKQET------GKDRKISNTWL----- 230
Cdd:cd23990 142 -----------------YEN---ASVVLP---AFYNTRNTDVSIrvkyvlDDFESQQAvyyfhpQYLLNVSRFWLrqgvr 198

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6097863  231 ----STGWFTMTIALELCDRIDVYGMVPpdFCRDPKHPSVPYHYYEPSGP 276
Cdd:cd23990 199 akriSSGLMLVTAALELCEEVHLYGFWA--FPMNPSGIFITHHYYDNVKP 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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