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Concise Results
Standard Results
Full Results
NADP-dependent isocitrate dehydrogenase [Plantibacter sp. PA-3-X8]
Protein Classification
NADP-dependent isocitrate dehydrogenase ( domain architecture ID 10013037 )
isocitrate dehydrogenase (NADP(+)) converts isocitrate to 2-oxoglutarate in an NADP-dependent manner
List of domain hits
Name
Accession
Description
Interval
E-value
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
1-403
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 906.54
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 1 M S KIKV EGT VVELDGDEMTRIIW Q FIKD S LI H PYLD VN LEYYDLGIE K RD E TDDQ I TIDAA H AI Q K H GVGVKCATITPDE 80
Cdd:PRK08299 1 M A KIKV KNP VVELDGDEMTRIIW K FIKD K LI L PYLD ID LEYYDLGIE N RD A TDDQ V TIDAA N AI K K Y GVGVKCATITPDE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 81 ARV E EF G LKKMW R SPNGTIRNILGG VI FREPII IS N I PRLVPGW N KPI I IGRHA F GDQYRATDF LFK G E GKLT VE FT PD D 160
Cdd:PRK08299 81 ARV K EF N LKKMW K SPNGTIRNILGG TV FREPII CK N V PRLVPGW T KPI V IGRHA Y GDQYRATDF KVP G K GKLT LV FT GE D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 161 G s EP QKF EV FQS PG D G I A QVQ YNLD A SIRDFARAS L NYGL N R N YPVYLSTKNTILKAYDGRFKDIFQE IFD AEFKE R FEA 240
Cdd:PRK08299 161 G - EP IEH EV HDF PG A G V A MGM YNLD E SIRDFARAS F NYGL D R K YPVYLSTKNTILKAYDGRFKDIFQE VYE AEFKE K FEA 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 241 AGITYEHRLIDDMVASA M KWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVL A TPDGK I VEAEAAHGTVTRHYRQHQ Q 320
Cdd:PRK08299 240 AGITYEHRLIDDMVASA L KWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVL M TPDGK T VEAEAAHGTVTRHYRQHQ K 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 321 G KP TSTNPIASIFAWTRGL Q HRG V LDGN Q EL IE FA A TLE D V V I K TVESG A MTKDLALLVGPDQ AYQ TTEEFL ET I SA NL K 400
Cdd:PRK08299 320 G EE TSTNPIASIFAWTRGL A HRG K LDGN P EL VK FA D TLE K V C I E TVESG F MTKDLALLVGPDQ KWL TTEEFL DA I DE NL E 399
...
gi 1526356920 401 AR L 403
Cdd:PRK08299 400 KA L 402
Name
Accession
Description
Interval
E-value
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
1-403
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 906.54
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 1 M S KIKV EGT VVELDGDEMTRIIW Q FIKD S LI H PYLD VN LEYYDLGIE K RD E TDDQ I TIDAA H AI Q K H GVGVKCATITPDE 80
Cdd:PRK08299 1 M A KIKV KNP VVELDGDEMTRIIW K FIKD K LI L PYLD ID LEYYDLGIE N RD A TDDQ V TIDAA N AI K K Y GVGVKCATITPDE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 81 ARV E EF G LKKMW R SPNGTIRNILGG VI FREPII IS N I PRLVPGW N KPI I IGRHA F GDQYRATDF LFK G E GKLT VE FT PD D 160
Cdd:PRK08299 81 ARV K EF N LKKMW K SPNGTIRNILGG TV FREPII CK N V PRLVPGW T KPI V IGRHA Y GDQYRATDF KVP G K GKLT LV FT GE D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 161 G s EP QKF EV FQS PG D G I A QVQ YNLD A SIRDFARAS L NYGL N R N YPVYLSTKNTILKAYDGRFKDIFQE IFD AEFKE R FEA 240
Cdd:PRK08299 161 G - EP IEH EV HDF PG A G V A MGM YNLD E SIRDFARAS F NYGL D R K YPVYLSTKNTILKAYDGRFKDIFQE VYE AEFKE K FEA 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 241 AGITYEHRLIDDMVASA M KWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVL A TPDGK I VEAEAAHGTVTRHYRQHQ Q 320
Cdd:PRK08299 240 AGITYEHRLIDDMVASA L KWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVL M TPDGK T VEAEAAHGTVTRHYRQHQ K 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 321 G KP TSTNPIASIFAWTRGL Q HRG V LDGN Q EL IE FA A TLE D V V I K TVESG A MTKDLALLVGPDQ AYQ TTEEFL ET I SA NL K 400
Cdd:PRK08299 320 G EE TSTNPIASIFAWTRGL A HRG K LDGN P EL VK FA D TLE K V C I E TVESG F MTKDLALLVGPDQ KWL TTEEFL DA I DE NL E 399
...
gi 1526356920 401 AR L 403
Cdd:PRK08299 400 KA L 402
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
2-404
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 650.78
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 2 SKIKV EGT VVE L DGDEMTRIIW QF IKD S LI H PY LDVN L E YYDLG I E K RD E T D DQ I T I DAA H AI Q K HG VGVKCATITPDEA 81
Cdd:TIGR00127 1 SKIKV ANP VVE M DGDEMTRIIW EL IKD K LI L PY VELD L K YYDLG V E Y RD A T N DQ V T V DAA E AI K K YN VGVKCATITPDEA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 82 RVEEF G LKKMW R SPNGTIRNILGG VI FREPII IS NIPRLVPGW N KPIIIGRHAFGDQYRATDF LFK G E GKL TVEFT P D DG 161
Cdd:TIGR00127 81 RVEEF K LKKMW K SPNGTIRNILGG TV FREPII CK NIPRLVPGW E KPIIIGRHAFGDQYRATDF VVP G P GKL ELVYK P K DG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 162 SEPQKFE V FQSPGD G - I A QVQ YN L D A SI RD FA RA S LNYG L NRNY P V YLSTKNTILK A YDGRFKDIFQE IFD A EF K ER FEA 240
Cdd:TIGR00127 161 TQKVTLK V YDFEEG G g V A MAM YN T D E SI EG FA HS S FQLA L EKKW P L YLSTKNTILK K YDGRFKDIFQE VYE A QY K SK FEA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 241 A GI T YEHRLIDDMVA S A M K W EGG YV WACKNYDGDVQSD T VAQGFGSLGLMTSVL AT PDGK IV EAEAAHGTVTRHYR QH Q Q 320
Cdd:TIGR00127 241 L GI W YEHRLIDDMVA Q A L K S EGG FI WACKNYDGDVQSD I VAQGFGSLGLMTSVL IC PDGK TF EAEAAHGTVTRHYR MY Q K 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 321 G KP TSTN P IASIFAW T RGL Q HR GV LD G N Q EL IE FA AT LE DVV I K TVE S G A MTKDLAL LV G PD ---- Q AY QT TEEF LETIS 396
Cdd:TIGR00127 321 G QE TSTN S IASIFAW S RGL A HR AK LD N N P EL SK FA NI LE SAC I N TVE A G I MTKDLAL IL G GS pver S AY LN TEEF IDAVE 400
....*...
gi 1526356920 397 AN LK ARL A 404
Cdd:TIGR00127 401 ER LK KKI A 408
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
2-401
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 532.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 2 S KIKVE G --------- TVVELD GD ---- E M TR I IW QF I KDSLIHP Y --- L D VNLEYY D L G IEK RDET D D QITIDA A H AI Q 65
Cdd:COG0538 4 E KIKVE D gklkvpdnp IIPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk R D IEWKEV D A G EKA RDET G D WLPDET A E AI K 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 66 KH GVG V K CATI TP DEA rveefglkk M WRS P N G TIR N IL GGVIF R E P I - IISNI P RL V PGWN K - P I I I G R HAFG D Q Y RATD 143
Cdd:COG0538 84 EY GVG I K GPLT TP VGG --------- G WRS L N V TIR Q IL DLYVC R R P V r YFKGV P SP V KHPE K v D I V I F R ENTE D I Y AGIE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 144 FLFKGEGK L TVE F TPD D GSEPQKFEVFQSP gd GI AQVQYN l D ASIRDFA RA SLN Y G L NRN - YP V Y L ST K NT I L K AYD G R F 222
Cdd:COG0538 155 WKAGSPEA L KLI F FLE D EMGVTVIRFPEDS -- GI GIKPVS - D EGTERLV RA AIQ Y A L DNK r KS V T L VH K GN I M K FTE G A F 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 223 KD IFQ E IFDA EF KER F ------------- E A AG I T Y EH R LI DDM VASAMKWE G G Y - V W A C KN YD GD VQ SD TV A QGF G S LG 288
Cdd:COG0538 232 KD WGY E VAEE EF GDK F itegpwekykgpk P A GK I V Y KD R IA DDM LQQILLRP G E Y d V I A T KN LN GD YI SD AL A AQV G G LG 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 289 LMTSVLATP DG K i V E A EA A HGT VTRH yrqhqq GKPT STNP IAS I FAW T RG L Q HRG V L DG nqelief A ATL E DV V I KT V ES 368
Cdd:COG0538 312 IAPGANIGD DG G - A E F EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HRG W L EA ------- A DLI E KA V E KT I ES 377
410 420 430
....*....|....*....|....*....|...
gi 1526356920 369 G AM T K DLA L L V g PDQAYQT T E EF LET I SA NL KA 401
Cdd:COG0538 378 G KV T Y DLA R L M - EGATELS T S EF GDA I IE NL DK 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
14-395
1.80e-77
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 243.36
E-value: 1.80e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 14 D G D E MTRIIWQFI K DS L IHPY L DVNL E YY D L G IEKR DET DDQITIDAAH A IQ K HGVGVKC A TIT P D ---- EA R V E E f GL K 89
Cdd:pfam00180 10 I G P E VMAAALKVL K AA L EKAP L EFEF E ER D V G GAAI DET GEPLPDETLE A CK K ADAVLLG A VGG P K wdpa GV R P E N - GL L 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 90 KMWRSP n G TIR N ILGGVI F R e P IIISNIPRLVPGW n KP I I I G R HAF G DQ Y R atdflfkgegkltveftpdd G S E PQKFEV 169
Cdd:pfam00180 89 ALRKEL - G LFA N LRPAKV F P - P LGDASPLKNEVEG - VD I V I V R ELT G GI Y F -------------------- G I E KGIKGS 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 170 FQSPGDGIA qv Q Y NL D A s I RDF AR ASLNYGLN R N - YP V YLST K NTI LK AY D g RFKD I FQ E IFD AE FKE rfeaag ITY EH R 248
Cdd:pfam00180 146 GNEVAVDTK -- L Y SR D E - I ERI AR VAFELARK R G r KK V TSVD K ANV LK SS D - LWRK I VT E VAK AE YPD ------ VEL EH Q 215
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 249 L I D DMVASAM K WEGGY - V WACK N YD GD VQ SD TVAQGF GSLGL MT S VLATPD G k IVEA E AA HG TVTRHYRQHQ qgkpts T N 327
Cdd:pfam00180 216 L V D NAAMQLV K NPSQF d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKGI ------ A N 288
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1526356920 328 PIA S I FAWTRG L QHRGV L D gnqeli EF A ATL E DV V I K TV ESG AM T K DLA L lvgp DQA Y QT T E EF L E TI 395
Cdd:pfam00180 289 PIA T I LSAAMM L RYSLG L E ------ DA A DKI E AA V L K VL ESG IR T G DLA G ---- SAT Y VS T S EF G E AV 346
Name
Accession
Description
Interval
E-value
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
1-403
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 906.54
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 1 M S KIKV EGT VVELDGDEMTRIIW Q FIKD S LI H PYLD VN LEYYDLGIE K RD E TDDQ I TIDAA H AI Q K H GVGVKCATITPDE 80
Cdd:PRK08299 1 M A KIKV KNP VVELDGDEMTRIIW K FIKD K LI L PYLD ID LEYYDLGIE N RD A TDDQ V TIDAA N AI K K Y GVGVKCATITPDE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 81 ARV E EF G LKKMW R SPNGTIRNILGG VI FREPII IS N I PRLVPGW N KPI I IGRHA F GDQYRATDF LFK G E GKLT VE FT PD D 160
Cdd:PRK08299 81 ARV K EF N LKKMW K SPNGTIRNILGG TV FREPII CK N V PRLVPGW T KPI V IGRHA Y GDQYRATDF KVP G K GKLT LV FT GE D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 161 G s EP QKF EV FQS PG D G I A QVQ YNLD A SIRDFARAS L NYGL N R N YPVYLSTKNTILKAYDGRFKDIFQE IFD AEFKE R FEA 240
Cdd:PRK08299 161 G - EP IEH EV HDF PG A G V A MGM YNLD E SIRDFARAS F NYGL D R K YPVYLSTKNTILKAYDGRFKDIFQE VYE AEFKE K FEA 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 241 AGITYEHRLIDDMVASA M KWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVL A TPDGK I VEAEAAHGTVTRHYRQHQ Q 320
Cdd:PRK08299 240 AGITYEHRLIDDMVASA L KWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVL M TPDGK T VEAEAAHGTVTRHYRQHQ K 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 321 G KP TSTNPIASIFAWTRGL Q HRG V LDGN Q EL IE FA A TLE D V V I K TVESG A MTKDLALLVGPDQ AYQ TTEEFL ET I SA NL K 400
Cdd:PRK08299 320 G EE TSTNPIASIFAWTRGL A HRG K LDGN P EL VK FA D TLE K V C I E TVESG F MTKDLALLVGPDQ KWL TTEEFL DA I DE NL E 399
...
gi 1526356920 401 AR L 403
Cdd:PRK08299 400 KA L 402
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-404
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 791.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 1 MS KIKV EGT VVELDGDEMTRIIW QF IK DS LI H PYLDV NLE YYDL G IE K RD E TDD QI T I DAA H AI Q KH G VG V KCATITPDE 80
Cdd:PTZ00435 3 GG KIKV KNP VVELDGDEMTRIIW KM IK EK LI L PYLDV PIK YYDL S IE N RD K TDD KV T V DAA E AI K KH K VG I KCATITPDE 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 81 ARV E EF G LKKMW R SPNGTIRNIL G G VI FREPIII S NIPRLVPGW N KPI I IGRHAFGDQY R ATDF LFK G E GKL TVE FTP D D 160
Cdd:PTZ00435 83 ARV K EF N LKKMW K SPNGTIRNIL D G TV FREPIII K NIPRLVPGW K KPI V IGRHAFGDQY K ATDF VVD G P GKL ELV FTP A D 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 161 GSEPQ KFE VF QSP G D G I A QVQ YN L D A SI RD FAR ASLN Y G L N R NY P V YLSTKNTILK A YDGRFKDIFQEI F D A E F K ER FE A 240
Cdd:PTZ00435 163 GSEPQ RVD VF DFK G G G V A MGM YN T D E SI EG FAR SCFQ Y A L D R KM P L YLSTKNTILK K YDGRFKDIFQEI Y D E E Y K AK FE K 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 241 AG IT YEHRLIDDMVA S A M K W EGG Y VWACKNYDGDVQSD T VAQG F GSLGLMTSVL AT PDGK I VEAEAAHGTVTRHYRQHQ Q 320
Cdd:PTZ00435 243 AG LW YEHRLIDDMVA Q A I K S EGG F VWACKNYDGDVQSD I VAQG Y GSLGLMTSVL VC PDGK T VEAEAAHGTVTRHYRQHQ K 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 321 GK P TSTN P IASIFAWTRGL Q HR GV LD G NQEL IE F AAT LE DVV I K T V E S G A MTKDLA LL V - G PDQA ---- Y QT TEEF LETI 395
Cdd:PTZ00435 323 GK E TSTN S IASIFAWTRGL A HR AK LD N NQEL VK F CQA LE RSC I E T I E A G F MTKDLA IC V h G SSKV trsd Y LN TEEF IDKV 402
....*....
gi 1526356920 396 SAN LK AR L A 404
Cdd:PTZ00435 403 AEK LK KK L G 411
PLN03065
PLN03065 isocitrate dehydrogenase (NADP+); Provisional
2-403
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain]
Cd Length: 483
Bit Score: 687.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 2 SK IKV EGTV VE L DGDEMTR I IWQ F IKD S LI H PYLD VNLE Y Y DLGI EK RD E TDD QI T IDA A H A IQ K HG V GV KCATITPDEA 81
Cdd:PLN03065 72 DR IKV QNPI VE M DGDEMTR V IWQ M IKD K LI F PYLD LDIK Y F DLGI LN RD A TDD KV T VES A E A TL K YN V AI KCATITPDEA 151
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 82 RV E EFGLK K MWRSPNGTIRNIL G G VI FREPI IIS NIPRLVPGW N KPI I IGRHAFGDQYRATD FLF KG E GKL TVE F T P D DG 161
Cdd:PLN03065 152 RV K EFGLK S MWRSPNGTIRNIL N G TV FREPI LCK NIPRLVPGW K KPI C IGRHAFGDQYRATD TVI KG P GKL KMV F V P E DG 231
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 162 SE P QKFE V FQSP G D G I A QVQ YN L D A SIR D FA RA S LNYG L NRNY P V YLSTKNTILK A YDGRFKDIFQE IFDAEF K ER FE AA 241
Cdd:PLN03065 232 NA P VELD V YDFK G P G V A LAM YN V D E SIR A FA ES S MAMA L QKKW P L YLSTKNTILK K YDGRFKDIFQE VYEEQW K QK FE EH 311
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 242 G I T YEHRLIDDMVA S A M K W EGGYVWACKNYDGDVQSD TV AQGFGSLGLMTSVL ATP DGK IV EAEAAHGTVTRH Y R Q HQ Q G 321
Cdd:PLN03065 312 S I W YEHRLIDDMVA Y A V K S EGGYVWACKNYDGDVQSD LL AQGFGSLGLMTSVL LSS DGK TL EAEAAHGTVTRH F R L HQ K G 391
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 322 KP TSTN P IASIFAWTRGL Q HR GV LD G N Q EL IE F AAT LE DVV I K TVESG A MTKDLA L L V - GP DQA --- Y QT TEEF LETISA 397
Cdd:PLN03065 392 QE TSTN S IASIFAWTRGL E HR AK LD K N E EL LD F VHK LE SAC I E TVESG K MTKDLA I L I h GP KVS ref Y LN TEEF IDAVAQ 471
....*.
gi 1526356920 398 N L KARL 403
Cdd:PLN03065 472 T L ATKR 477
PLN00103
PLN00103 isocitrate dehydrogenase (NADP+); Provisional
3-403
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720
Cd Length: 410
Bit Score: 661.91
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 3 KIKV EGTV VE L DGDEMTR I IW QF IKD S LI H P Y LD VNLE Y Y DLG IEK RD E TDD QI T IDA A H A IQ K HG V GV KCATITPDEAR 82
Cdd:PLN00103 5 KIKV ANPI VE M DGDEMTR V IW KS IKD K LI F P F LD LDIK Y F DLG LPN RD A TDD KV T VES A E A TL K YN V AI KCATITPDEAR 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 83 V E EFGLK K MW R SPNGTIRNIL G G VI FREPII IS NIPRLVPGW N KPI I IGRHAFGDQYRATD FLF KG E GKL TVE F T P DDGS 162
Cdd:PLN00103 85 V K EFGLK Q MW K SPNGTIRNIL N G TV FREPII CK NIPRLVPGW T KPI C IGRHAFGDQYRATD AVI KG P GKL KLV F V P EGKD 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 163 E PQKF EV FQSP G D - G I A QVQ YN L D A SIR D FA R AS L N YGLNRNY P V YLSTKNTILK A YDGRFKDIFQE IFD A EF K ER FEAA 241
Cdd:PLN00103 165 E KTEL EV YNFT G A g G V A LSM YN T D E SIR A FA E AS M N TAYQKKW P L YLSTKNTILK K YDGRFKDIFQE VYE A QW K SK FEAA 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 242 GI T YEHRLIDDMVA S A M K W EGGYVWACKNYDGDVQSD TV AQGFGSLGLMTSVL AT PDGK IV EAEAAHGTVTRHYR Q HQ Q G 321
Cdd:PLN00103 245 GI W YEHRLIDDMVA Y A L K S EGGYVWACKNYDGDVQSD FL AQGFGSLGLMTSVL VC PDGK TI EAEAAHGTVTRHYR V HQ K G 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 322 KP TSTN P IASIFAW T RGL Q HR GV LDGN QE L IE F AAT LE DVVIK TVESG A MTKDLALL V - GP D --- QA Y QT TEEF LETISA 397
Cdd:PLN00103 325 GE TSTN S IASIFAW S RGL A HR AK LDGN AR L LD F TEK LE AACVG TVESG K MTKDLALL I h GP K vsr DQ Y LN TEEF IDAVAE 404
....*.
gi 1526356920 398 N LKARL 403
Cdd:PLN00103 405 E LKARL 410
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
2-404
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 650.78
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 2 SKIKV EGT VVE L DGDEMTRIIW QF IKD S LI H PY LDVN L E YYDLG I E K RD E T D DQ I T I DAA H AI Q K HG VGVKCATITPDEA 81
Cdd:TIGR00127 1 SKIKV ANP VVE M DGDEMTRIIW EL IKD K LI L PY VELD L K YYDLG V E Y RD A T N DQ V T V DAA E AI K K YN VGVKCATITPDEA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 82 RVEEF G LKKMW R SPNGTIRNILGG VI FREPII IS NIPRLVPGW N KPIIIGRHAFGDQYRATDF LFK G E GKL TVEFT P D DG 161
Cdd:TIGR00127 81 RVEEF K LKKMW K SPNGTIRNILGG TV FREPII CK NIPRLVPGW E KPIIIGRHAFGDQYRATDF VVP G P GKL ELVYK P K DG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 162 SEPQKFE V FQSPGD G - I A QVQ YN L D A SI RD FA RA S LNYG L NRNY P V YLSTKNTILK A YDGRFKDIFQE IFD A EF K ER FEA 240
Cdd:TIGR00127 161 TQKVTLK V YDFEEG G g V A MAM YN T D E SI EG FA HS S FQLA L EKKW P L YLSTKNTILK K YDGRFKDIFQE VYE A QY K SK FEA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 241 A GI T YEHRLIDDMVA S A M K W EGG YV WACKNYDGDVQSD T VAQGFGSLGLMTSVL AT PDGK IV EAEAAHGTVTRHYR QH Q Q 320
Cdd:TIGR00127 241 L GI W YEHRLIDDMVA Q A L K S EGG FI WACKNYDGDVQSD I VAQGFGSLGLMTSVL IC PDGK TF EAEAAHGTVTRHYR MY Q K 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 321 G KP TSTN P IASIFAW T RGL Q HR GV LD G N Q EL IE FA AT LE DVV I K TVE S G A MTKDLAL LV G PD ---- Q AY QT TEEF LETIS 396
Cdd:TIGR00127 321 G QE TSTN S IASIFAW S RGL A HR AK LD N N P EL SK FA NI LE SAC I N TVE A G I MTKDLAL IL G GS pver S AY LN TEEF IDAVE 400
....*...
gi 1526356920 397 AN LK ARL A 404
Cdd:TIGR00127 401 ER LK KKI A 408
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
2-401
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 532.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 2 S KIKVE G --------- TVVELD GD ---- E M TR I IW QF I KDSLIHP Y --- L D VNLEYY D L G IEK RDET D D QITIDA A H AI Q 65
Cdd:COG0538 4 E KIKVE D gklkvpdnp IIPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk R D IEWKEV D A G EKA RDET G D WLPDET A E AI K 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 66 KH GVG V K CATI TP DEA rveefglkk M WRS P N G TIR N IL GGVIF R E P I - IISNI P RL V PGWN K - P I I I G R HAFG D Q Y RATD 143
Cdd:COG0538 84 EY GVG I K GPLT TP VGG --------- G WRS L N V TIR Q IL DLYVC R R P V r YFKGV P SP V KHPE K v D I V I F R ENTE D I Y AGIE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 144 FLFKGEGK L TVE F TPD D GSEPQKFEVFQSP gd GI AQVQYN l D ASIRDFA RA SLN Y G L NRN - YP V Y L ST K NT I L K AYD G R F 222
Cdd:COG0538 155 WKAGSPEA L KLI F FLE D EMGVTVIRFPEDS -- GI GIKPVS - D EGTERLV RA AIQ Y A L DNK r KS V T L VH K GN I M K FTE G A F 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 223 KD IFQ E IFDA EF KER F ------------- E A AG I T Y EH R LI DDM VASAMKWE G G Y - V W A C KN YD GD VQ SD TV A QGF G S LG 288
Cdd:COG0538 232 KD WGY E VAEE EF GDK F itegpwekykgpk P A GK I V Y KD R IA DDM LQQILLRP G E Y d V I A T KN LN GD YI SD AL A AQV G G LG 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 289 LMTSVLATP DG K i V E A EA A HGT VTRH yrqhqq GKPT STNP IAS I FAW T RG L Q HRG V L DG nqelief A ATL E DV V I KT V ES 368
Cdd:COG0538 312 IAPGANIGD DG G - A E F EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HRG W L EA ------- A DLI E KA V E KT I ES 377
410 420 430
....*....|....*....|....*....|...
gi 1526356920 369 G AM T K DLA L L V g PDQAYQT T E EF LET I SA NL KA 401
Cdd:COG0538 378 G KV T Y DLA R L M - EGATELS T S EF GDA I IE NL DK 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
14-395
1.80e-77
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 243.36
E-value: 1.80e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 14 D G D E MTRIIWQFI K DS L IHPY L DVNL E YY D L G IEKR DET DDQITIDAAH A IQ K HGVGVKC A TIT P D ---- EA R V E E f GL K 89
Cdd:pfam00180 10 I G P E VMAAALKVL K AA L EKAP L EFEF E ER D V G GAAI DET GEPLPDETLE A CK K ADAVLLG A VGG P K wdpa GV R P E N - GL L 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 90 KMWRSP n G TIR N ILGGVI F R e P IIISNIPRLVPGW n KP I I I G R HAF G DQ Y R atdflfkgegkltveftpdd G S E PQKFEV 169
Cdd:pfam00180 89 ALRKEL - G LFA N LRPAKV F P - P LGDASPLKNEVEG - VD I V I V R ELT G GI Y F -------------------- G I E KGIKGS 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 170 FQSPGDGIA qv Q Y NL D A s I RDF AR ASLNYGLN R N - YP V YLST K NTI LK AY D g RFKD I FQ E IFD AE FKE rfeaag ITY EH R 248
Cdd:pfam00180 146 GNEVAVDTK -- L Y SR D E - I ERI AR VAFELARK R G r KK V TSVD K ANV LK SS D - LWRK I VT E VAK AE YPD ------ VEL EH Q 215
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 249 L I D DMVASAM K WEGGY - V WACK N YD GD VQ SD TVAQGF GSLGL MT S VLATPD G k IVEA E AA HG TVTRHYRQHQ qgkpts T N 327
Cdd:pfam00180 216 L V D NAAMQLV K NPSQF d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKGI ------ A N 288
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1526356920 328 PIA S I FAWTRG L QHRGV L D gnqeli EF A ATL E DV V I K TV ESG AM T K DLA L lvgp DQA Y QT T E EF L E TI 395
Cdd:pfam00180 289 PIA T I LSAAMM L RYSLG L E ------ DA A DKI E AA V L K VL ESG IR T G DLA G ---- SAT Y VS T S EF G E AV 346
PLN00096
PLN00096 isocitrate dehydrogenase (NADP+); Provisional
10-399
4.34e-59
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177715
Cd Length: 393
Bit Score: 197.18
E-value: 4.34e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 10 V V ELD G D EMTR IIWQF I KDSL I H P YL D VN - L E YY DL GIEK RD E T D DQ ITI D AAH A IQKHGVGV K CA TITP DEAR V EEF GL 88
Cdd:PLN00096 1 M V YVA G E EMTR YTMDL I LAKW I E P HV D TS a W E FF DL RAKN RD D T E DQ VLR D VIE A GARLKAIF K EP TITP TADQ V KRL GL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 89 KK M W R SPNG TI R NILG G V - I F R EP I I I SNIPR lvp G WN KP IIIG RHA F G DQ Y R A t DFLFK G E G K L TVE F T P DD G SE P QKF 167
Cdd:PLN00096 81 KK A W G SPNG AM R RGWN G I t I S R DT I H I DGVEL --- G YK KP VFFE RHA V G GE Y S A - GYKIV G K G T L VTT F V P EE G GK P IVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 168 EVFQSPG D GI A Q V Q Y N -- LD a SIRDF AR ASLNYG L NRNYPV Y LS TK N T IL K a YDGR F KD I FQEI FD A EFK ER F EAA G ITY 245
Cdd:PLN00096 157 DDRTITD D LN A V V T Y H np LD - NVHHL AR IFFGRC L DAGIVP Y VV TK K T VF K - WQEP F WE I MKKV FD E EFK SK F VDK G VMK 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 246 E ----- H R L I D DMVASAMK W - E GG YVW A CK NYDGDV QS D TV AQ GFG S L G LM TS V L ATP D GK --- I V E A EA A HGTVT RHYR 316
Cdd:PLN00096 235 S gdelv H L L S D AATMKLVV W t D GG FGM A AH NYDGDV LT D EL AQ VHK S P G FI TS N L VGV D EN gtl I K E F EA S HGTVT DMDE 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 317 QHQQ G KP TS T NP IASIFAWTRGLQ H RG - V LD G NQELIE F A A T L ED V VI K TVES G AM T K DL A llv G PDQA yq TTE E F LETI 395
Cdd:PLN00096 315 ARLR G EE TS L NP LGMVEGLIGAMN H AA d V HG G KERVHP F T A K L RA V IH K LFRE G RG T R DL C --- G AGGL -- TTE Q F IDAV 389
....
gi 1526356920 396 SAN L 399
Cdd:PLN00096 390 AEE L 393
PLN00118
PLN00118 isocitrate dehydrogenase (NAD+)
211-399
6.46e-04
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062
Cd Length: 372
Bit Score: 41.40
E-value: 6.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 211 K NT I L K AY DG R F KDIFQ E I f DAEFK E rfeaag I T YE HRL ID DMVASAM K WEGGY - V WACK N YD GD VQ SD TV A QGF G S LGL 289
Cdd:PLN00118 210 K AN I M K KT DG L F LKCCR E V - AEKYP E ------ I V YE EVI ID NCCMMLV K NPALF d V LVMP N LY GD II SD LC A GLI G G LGL 282
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 290 mtsvla TP DGK I V E ----- AEA A HG TVT rhyrq HQQ GK p TST NP I A SIFAWTRG L Q H RG vldgnqe L I E F A ATLEDVVIK 364
Cdd:PLN00118 283 ------ TP SCN I G E nglal AEA V HG SAP ----- DIA GK - NLA NP T A LLLSAVMM L R H LK ------- L N E Q A EQIHNAILN 343
170 180 190
....*....|....*....|....*....|....*.
gi 1526356920 365 T VES G A - M T K DL A llvgpdq AYQ TT EE F LET I SAN L 399
Cdd:PLN00118 344 T IAE G K y R T A DL G ------- GSS TT TD F TKA I CDH L 372
PRK06451
PRK06451 NADP-dependent isocitrate dehydrogenase;
52-380
4.24e-03
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803
Cd Length: 412
Bit Score: 39.04
E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 52 T DDQITIDAAHA I Q K HG V GV K CATI TP dearveefg LK K M W R S P N GT IR NI L GGVIFRE P I iisnip RLV PG WNK P I --- 128
Cdd:PRK06451 75 T GNRFPKESEEL I E K YR V LL K GPLE TP --------- IG K G W K S I N VA IR LM L DLYANIR P V ------ KYI PG IES P L knp 139
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 129 ----- II G R HAFG D Q YR ATDFLFKG - E G K LTVE F TPDD gsep QKF EV FQSP G D GI AQVQYNLDAS I rdf AR ASLN Y GLNR 202
Cdd:PRK06451 140 ekidl II F R ENTD D L YR GIEYPYDS e E A K KIRD F LRKE ---- LGV EV EDDT G I GI KLISKFKTQR I --- AR MAIK Y AIDH 212
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 203 NY - P V YLST K NTIL K AYD G R F KDIFQ E IFDA EF KERF -------------- EAAGITYEH R LI D D M VASAMKWEGG Y - VW 266
Cdd:PRK06451 213 KR k K V TIMH K GNVM K YTE G A F REWAY E VALK EF RDYV vteeevtknyngvp PSGKVIIND R IA D N M FQQIIIRPDE Y d II 292
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526356920 267 ACK N YD GD VQ SD TVAQGF G SL G LMTSVLATPD G KIV ea EA A HGT VTRH yrqhq Q GK PTS t NP IAS I FAWTRG L QHR G vld 346
Cdd:PRK06451 293 LAP N VN GD YI SD AAGALV G NI G MLGGANIGDT G GMF -- EA I HGT APKY ----- A GK NVA - NP TGI I KGGELM L RFM G --- 361
330 340 350
....*....|....*....|....*....|....
gi 1526356920 347 gnqe LIEF A ATLEDVVIKTVESGAM T K DLA LLV G 380
Cdd:PRK06451 362 ---- WDKA A DLIDKAIMESIKQKKV T Q DLA RFM G 391
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
