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Conserved domains on  [gi|1526225353|gb|AZH11763|]
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GntR family transcriptional regulator [Caulobacter vibrioides]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
70-298 5.12e-78

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 237.07  E-value: 5.12e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  70 PAPLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAA-RVEKNFSKLT 148
Cdd:COG2188     3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEpKIEYPLSRLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 149 CFTEDMRSRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTI---AGFALPSADAVKDSL 225
Cdd:COG2188    83 SFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLpaaLFPGLLEEDLETGSL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1526225353 226 YEAMAA-TGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYDFVAELN 298
Cdd:COG2188   163 YELLEErYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
70-298 5.12e-78

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 237.07  E-value: 5.12e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  70 PAPLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAA-RVEKNFSKLT 148
Cdd:COG2188     3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEpKIEYPLSRLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 149 CFTEDMRSRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTI---AGFALPSADAVKDSL 225
Cdd:COG2188    83 SFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLpaaLFPGLLEEDLETGSL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1526225353 226 YEAMAA-TGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYDFVAELN 298
Cdd:COG2188   163 YELLEErYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 156-292 1.17e-37

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 130.41  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 156 SRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIAGFALPS---ADAVKDSLYEAMAA- 231
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDlleEDLEEGSLYDYLEEr 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1526225353 232 TGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYD 292
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 156-292 1.08e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 117.78  E-value: 1.08e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  156 SRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIAG--FALPSADAVKDSLYEAMAA-- 231
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAalFPGLLEEDLSGSLYEYLEErl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1526225353  232 --TGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYD 292
Cdd:smart00866  81 glKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
PRK09764 PRK09764
GntR family transcriptional regulator;
72-293 1.08e-28

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 109.92  E-value: 1.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  72 PLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAA-RVEKNFSKLTCF 150
Cdd:PRK09764    5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEeRVNYDIFQLTSF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 151 TEDMRSRGRAPASEwiTRAEGAVTPEEAL--MLGVSPNTPVYRFHRIRIADGAPMAVEYT--TIAGFALPSADAVKDSLY 226
Cdd:PRK09764   85 DEKLSDRHVDTHSE--VLIFEVIPADDFLqqQLQITAQDRVWHVKRVRYRKQKPMALEETwmPLALFPDLTWQVMENSKY 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1526225353 227 EAMAATGHRPT-RALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYDF 293
Cdd:PRK09764  163 HFIEEVKKMVIdRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 72-137 3.61e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 90.20  E-value: 3.61e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1526225353  72 PLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVA 137
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 73-296 5.56e-23

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 94.85  E-value: 5.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  73 LYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAA-RVEKNFSKLTCFT 151
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAArRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 152 EDMRSRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIAGFALP---SADAVKDSLYEA 228
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPgigQAYAASGSITDA 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1526225353 229 M-AATGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYDFVAE 296
Cdd:TIGR02325 169 LrEQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTME 237
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
70-298 5.12e-78

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 237.07  E-value: 5.12e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  70 PAPLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAA-RVEKNFSKLT 148
Cdd:COG2188     3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEpKIEYPLSRLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 149 CFTEDMRSRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTI---AGFALPSADAVKDSL 225
Cdd:COG2188    83 SFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLpaaLFPGLLEEDLETGSL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1526225353 226 YEAMAA-TGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYDFVAELN 298
Cdd:COG2188   163 YELLEErYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 156-292 1.17e-37

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 130.41  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 156 SRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIAGFALPS---ADAVKDSLYEAMAA- 231
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDlleEDLEEGSLYDYLEEr 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1526225353 232 TGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYD 292
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 156-292 1.08e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 117.78  E-value: 1.08e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  156 SRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIAG--FALPSADAVKDSLYEAMAA-- 231
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAalFPGLLEEDLSGSLYEYLEErl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1526225353  232 --TGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYD 292
Cdd:smart00866  81 glKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
PRK09764 PRK09764
GntR family transcriptional regulator;
72-293 1.08e-28

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 109.92  E-value: 1.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  72 PLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAA-RVEKNFSKLTCF 150
Cdd:PRK09764    5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEeRVNYDIFQLTSF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 151 TEDMRSRGRAPASEwiTRAEGAVTPEEAL--MLGVSPNTPVYRFHRIRIADGAPMAVEYT--TIAGFALPSADAVKDSLY 226
Cdd:PRK09764   85 DEKLSDRHVDTHSE--VLIFEVIPADDFLqqQLQITAQDRVWHVKRVRYRKQKPMALEETwmPLALFPDLTWQVMENSKY 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1526225353 227 EAMAATGHRPT-RALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYDF 293
Cdd:PRK09764  163 HFIEEVKKMVIdRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
PRK11402 PRK11402
transcriptional regulator PhoB;
72-293 7.48e-26

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 102.61  E-value: 7.48e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  72 PLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAA-RVEKNFSKLTCF 150
Cdd:PRK11402    9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSqKVENALLTVSGF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 151 TEDMRSRGRAPASEWITRAEGAVTPeEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIAGFALPSADA-VKD--SLYE 227
Cdd:PRK11402   89 TDFGVSQGKATKEKVIEQERVSAAP-FCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEiYVEgsSTYQ 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1526225353 228 AMAATGH-RPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYDF 293
Cdd:PRK11402  168 LFQERFDtRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTL 234
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 72-137 3.61e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 90.20  E-value: 3.61e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1526225353  72 PLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVA 137
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 73-296 5.56e-23

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 94.85  E-value: 5.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  73 LYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAA-RVEKNFSKLTCFT 151
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAArRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 152 EDMRSRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIAGFALP---SADAVKDSLYEA 228
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPgigQAYAASGSITDA 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1526225353 229 M-AATGHRPTRALQRLRGVLISREHASLLGVKPKDAGLLVERRGYLRDGRAVEISHSYYRGDAYDFVAE 296
Cdd:TIGR02325 169 LrEQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTME 237
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 70-140 5.33e-20

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 89.50  E-value: 5.33e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1526225353  70 PAPLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAARV 140
Cdd:COG1167    10 SGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
72-179 1.93e-19

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 81.76  E-value: 1.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  72 PLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAARVEKNFSkltcft 151
Cdd:COG1725    10 PIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLE------ 83

                          90       100
                  ....*....|....*....|....*....
gi 1526225353 152 EDMRSRGRAPASEWITRAEGA-VTPEEAL 179
Cdd:COG1725    84 ERREEFLEEALRELVAEARRLgLSLEELL 112
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
70-145 8.99e-17

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 77.67  E-value: 8.99e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1526225353  70 PAPLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAARVEKNFS 145
Cdd:COG2186     5 RRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 73-136 3.69e-16

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 71.49  E-value: 3.69e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1526225353  73 LYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFV 136
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
79-136 7.54e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 70.30  E-value: 7.54e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1526225353   79 RALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFV 136
Cdd:smart00345   3 ERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK14999 PRK14999
histidine utilization repressor; Provisional
 70-270 8.74e-15

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 72.27  E-value: 8.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  70 PAPLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVA-ARVEKNFSKLT 148
Cdd:PRK14999   10 PAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAePKGQSALFEVR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 149 CFTEDMRSRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIagfalpSADAVKDSLYEA 228
Cdd:PRK14999   90 SIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCV------NADIAVDYLTQD 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1526225353 229 MAATghRPTRALQRL----------RGVLISREHASLLGVKPKDAGLLVERR 270
Cdd:PRK14999  164 YRQT--TPHAYLSRIapltegehivEAVRATAQECAWLTIKEHEPCLLIRRT 213
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
76-145 4.16e-13

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 67.74  E-value: 4.16e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  76 QLQRALREAIevkmLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAARVEKNFS 145
Cdd:PRK09464   18 QLEFLILEGT----LRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFS 83
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 76-141 4.83e-12

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 64.79  E-value: 4.83e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1526225353  76 QLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAARVE 141
Cdd:PRK10421    6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHE 71
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 76-296 1.34e-08

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 54.40  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  76 QLQRALREAIEVkmlapDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAAR-VEKNFSKLTCFTEDM 154
Cdd:PRK10079   20 KLEQELRQHYRC-----GDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRpYDYPLNAQARFSQNL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353 155 RSRGRAPASEWITRAEGAVTPEEALMLGVSPNTPVYRFHRIRIADGAPMAVEYTTIAGFAL-PSADAVKD-SLYEAMAAT 232
Cdd:PRK10079   95 LDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADLTWwPTLQRFDSgSLHDFLREQ 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1526225353 233 GHRP-TRALQRLRGVLISREHASLLGVkPKDAGLLVERRGYLRDG--RAVEISHSYYRGDAYDFVAE 296
Cdd:PRK10079  175 LGIAlRRSQTRISARRAQAKESQLLEI-PNMSPLLCVRTLNHRDGesSPAEYSVSLTRADMIEFTME 240
PRK10225 PRK10225
Uxu operon transcriptional regulator;
74-136 7.82e-08

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 52.33  E-value: 7.82e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1526225353  74 YLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFV 136
Cdd:PRK10225   11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
68-137 9.22e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 51.85  E-value: 9.22e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1526225353  68 AVPAPLYLQLQRALREAIEVKMLAPDDALPpERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVA 137
Cdd:COG1802     7 LRRESLAEQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVA 75
PRK11523 PRK11523
transcriptional regulator ExuR;
70-143 1.11e-07

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 51.77  E-value: 1.11e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1526225353  70 PAPLYLQLQRALREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVAARVEKN 143
Cdd:PRK11523    6 PRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRH 79
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 81-136 9.31e-04

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 40.41  E-value: 9.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1526225353  81 LREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFV 136
Cdd:PRK15481   14 IRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVI 69
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 81-131 1.15e-03

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 39.62  E-value: 1.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1526225353  81 LREAIEVKMLAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQG 131
Cdd:PRK03837   22 LEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHG 72
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 90-137 9.74e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 37.05  E-value: 9.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1526225353  90 LAPDDALPPERDMAEDFAVSRITVRKALEGLVSEGLLTRRQGAGTFVA 137
Cdd:PRK09990   25 LKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVA 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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