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Conserved domains on  [gi|1447669362|gb|AXN07772|]
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ROK family protein [Vibrio anguillarum]

Protein Classification

actin family protein( domain architecture ID 229483)

actin family protein similar to Caldicellulosiruptor bescii xylose repressor, a transcriptional repressor of xylose-utilizing enzymes

CATH:  3.30.420.40
Gene Ontology:  GO:0000166|GO:0003677
PubMed:  8800467|7781919

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 83-398 2.00e-147

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd24075:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 315  Bit Score: 420.62  E-value: 2.00e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  83 FHSVAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVV 162
Cdd:cd24075     1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 163 EYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEI 242
Cdd:cd24075    81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 243 GHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESSLaNIESITINDVCEHANLGDELAKQSLIRVGNQLGK 322
Cdd:cd24075   161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQL-TLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGK 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 323 AIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQIDKQPTIGAFAMIKRAMLNGVLL 398
Cdd:cd24075   240 VIAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-102 7.52e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00347:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 101  Bit Score: 41.43  E-value: 7.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362   22 RLIDLQGPISRIQVADVSQLAPASVTKITRQLLERGLIkevAQQASTGGRRA--ISLTTEVAPFHSVAVRLGRDYIQLSL 99
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV---RREPSPEDRRSvlVSLTEEGRELIEQLLEARSETLAELL 93


                   ...
gi 1447669362  100 YNL 102
Cdd:smart00347  94 AGL 96
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 83-398 2.00e-147

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 420.62  E-value: 2.00e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  83 FHSVAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVV 162
Cdd:cd24075     1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 163 EYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEI 242
Cdd:cd24075    81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 243 GHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESSLaNIESITINDVCEHANLGDELAKQSLIRVGNQLGK 322
Cdd:cd24075   161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQL-TLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGK 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 323 AIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQIDKQPTIGAFAMIKRAMLNGVLL 398
Cdd:cd24075   240 VIAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 84-390 1.19e-83

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 257.90  E-value: 1.19e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  84 HSVAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQ-LIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVV 162
Cdd:COG1940     6 YVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEaVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDPETGVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 163 EYMPNI-AIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGE 241
Cdd:COG1940    86 LNAPNLpGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGNAGE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 242 IGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIaqgyesslaNIESITINDVCEHANLGDELAKQSLIRVGNQLG 321
Cdd:COG1940   166 IGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELG---------GAEKLTAEELFAAARAGDPLALEVLDEAARYLG 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 322 KAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQI-DKQPTIGAFAMIKR 390
Cdd:COG1940   237 IGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLgDDAGLLGAAALALE 306
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 86-390 6.42e-72

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 227.22  E-value: 6.42e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  86 VAVRLGRDYIQLSLYNLGGKELASdyHEFHYShQTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVVEYM 165
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILAR--ERVPTP-TTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 166 PNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGHI 245
Cdd:pfam00480  78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 246 QIDPLGEQCQCGNFGCLETVAANPAIISRVKKliaQGyesslaniESITINDVCEHANLGDELAKQSLIRVGNQLGKAIA 325
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQ---KG--------EDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1447669362 326 MTINLFNPQKVVIAGQITaAQEIVFPAIQRNVENQSLKTFHTNL--PIVASQIDKQPTIGAFAMIKR 390
Cdd:pfam00480 227 NLINLFDPQAIVLGGGVS-NADGLLEAIRSLVKKYLNGYLPVPPviIVAASLGDNAGALGAAALAKQ 292
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 130-393 7.82e-36

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 133.49  E-value: 7.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 130 LNTFIKQQQERIEQFIAIGIALPGLVNPETGVVEYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDC 209
Cdd:TIGR00744  44 VDSFIQHIAKVGHEIVAIGIGAPGPVNRQRGTVYFAVNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 210 QDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGHIQIDPLGE-QCQCGNFGCLETVAANPAIISRVKKLIAQGYESS-- 286
Cdd:TIGR00744 124 RDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGHIRMVPDGRlLCNCGKQGCIETYASATGLVRYAKRANAKPERAEvl 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 287 --LANIESITINDVCEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKT 364
Cdd:TIGR00744 204 laLGDGDGISAKHVFVAARQGDPVAVDSYREVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSYKRWLFGG 283

                         250       260       270
                  ....*....|....*....|....*....|
gi 1447669362 365 FHTNLPIVASQI-DKQPTIGAFAMIKRAML 393
Cdd:TIGR00744 284 ARQVADIIAAQLgNDAGLVGAADLARTYII 313
PRK09698 PRK09698
D-allose kinase; Provisional
 118-356 4.69e-20

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 89.66  E-value: 4.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 118 HQTQ--LIEGLLFHLNTFIKQQQERIEQFI-AIGIALPGLVNPETGVVEYMPNI---AIDALALGDIIRDNFHVECFVGN 191
Cdd:PRK09698   33 KRTAevIAPDLVSGLGEMIDEYLRRFNARChGIVMGFPALVSKDRRTVISTPNLpltALDLYDLADKLENTLNCPVFFSR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 192 DVRGMAL--AEHYfgaskDCQDSILVSVHRGTGAG--IIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAA 267
Cdd:PRK09698  113 DVNLQLLwdVKEN-----NLTQQLVLGAYLGTGMGfaVWMNGAPWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCS 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 268 NPAiISRVkkliaqgYESSLANiesITINDVCEHAnlGDELAKQSLIrvgNQLGKAIAMTINLFNPQKVVIAGQITAAQE 347
Cdd:PRK09698  188 GMA-LRRW-------YEQQPRD---YPLSDLFVHA--GDHPFIQSLL---ENLARAIATSINLFDPDAIILGGGVMDMPA 251

                         250
                  ....*....|....*
gi 1447669362 348 ivFP------AIQRN 356
Cdd:PRK09698  252 --FPretliaMIQKY 264
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
22-102 7.52e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 41.43  E-value: 7.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362   22 RLIDLQGPISRIQVADVSQLAPASVTKITRQLLERGLIkevAQQASTGGRRA--ISLTTEVAPFHSVAVRLGRDYIQLSL 99
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV---RREPSPEDRRSvlVSLTEEGRELIEQLLEARSETLAELL 93


                   ...
gi 1447669362  100 YNL 102
Cdd:smart00347  94 AGL 96
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 22-74 1.12e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 36.76  E-value: 1.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1447669362  22 RLIDLQGPISRIQVADVSQLAPASVTKITRQLLERGLIKevaQQASTGGRRAI 74
Cdd:pfam01047  10 RILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE---RSRSPEDRREV 59
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
19-79 1.55e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 38.65  E-value: 1.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447669362  19 AVYRLIDLQGPISRIQVADVSQLAPASVTKITRQLLERGLIKEVaqqastgGRRAISLTTE 79
Cdd:COG1321    14 AIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYE-------PYGGITLTEE 67
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 83-398 2.00e-147

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 420.62  E-value: 2.00e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  83 FHSVAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVV 162
Cdd:cd24075     1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 163 EYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEI 242
Cdd:cd24075    81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 243 GHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESSLaNIESITINDVCEHANLGDELAKQSLIRVGNQLGK 322
Cdd:cd24075   161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQL-TLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGK 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 323 AIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQIDKQPTIGAFAMIKRAMLNGVLL 398
Cdd:cd24075   240 VIAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 83-402 2.21e-101

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 303.85  E-value: 2.21e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  83 FHSVAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVV 162
Cdd:cd24074     2 WQFLSIRIGRGYITLALRDLNGRLLAEERYPLPAKDNDPFLDRLLESISEFFSRHQKKLERLTAIAITLPGIIDPESGIV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 163 EYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEI 242
Cdd:cd24074    82 HRLPFYDIKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 243 GHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQgYESSLANIESITINDVCEHANLGDELAKQSLIRVGNQLGK 322
Cdd:cd24074   162 GHTQIDPYGKRCYCGNHGCLETVASIPAILEQANQLLEQ-SPDSMLHGQPISIESLCQAALAGDPLAQDIIIQVGRHLGR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 323 AIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQIDKQPTIGAFAMIKRAMLNGVLLQKLL 402
Cdd:cd24074   241 ILAILVNLFNPEKILIGSPLNNAAEILFPALSQSIRQQSLPAYSQHLQIESTKFYNDGTMPGAALIKDALYDGSLLLKLL 320
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 84-390 1.19e-83

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 257.90  E-value: 1.19e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  84 HSVAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQ-LIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVV 162
Cdd:COG1940     6 YVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEaVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDPETGVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 163 EYMPNI-AIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGE 241
Cdd:COG1940    86 LNAPNLpGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGNAGE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 242 IGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIaqgyesslaNIESITINDVCEHANLGDELAKQSLIRVGNQLG 321
Cdd:COG1940   166 IGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELG---------GAEKLTAEELFAAARAGDPLALEVLDEAARYLG 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 322 KAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQI-DKQPTIGAFAMIKR 390
Cdd:COG1940   237 IGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLgDDAGLLGAAALALE 306
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 86-390 6.42e-72

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 227.22  E-value: 6.42e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  86 VAVRLGRDYIQLSLYNLGGKELASdyHEFHYShQTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVVEYM 165
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILAR--ERVPTP-TTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 166 PNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGHI 245
Cdd:pfam00480  78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 246 QIDPLGEQCQCGNFGCLETVAANPAIISRVKKliaQGyesslaniESITINDVCEHANLGDELAKQSLIRVGNQLGKAIA 325
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQ---KG--------EDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1447669362 326 MTINLFNPQKVVIAGQITaAQEIVFPAIQRNVENQSLKTFHTNL--PIVASQIDKQPTIGAFAMIKR 390
Cdd:pfam00480 227 NLINLFDPQAIVLGGGVS-NADGLLEAIRSLVKKYLNGYLPVPPviIVAASLGDNAGALGAAALAKQ 292
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 84-387 1.35e-68

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 218.97  E-value: 1.35e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  84 HSVAVRLGRDYIQLSLYNLGGKELASdyHEFHYSH---QTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETG 160
Cdd:cd24076     2 AVIGVELGVDYITVVVTDLAGEVLWR--REVPLPAsddPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 161 VVEYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVG 240
Cdd:cd24076    80 VVLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 241 EIGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESSLANIEsitindvcEHANLGDELAKQSLIRVGNQL 320
Cdd:cd24076   160 EIGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGGEPLSLAELV--------EAARAGDPAALAALEEVGEYL 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1447669362 321 GKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQIDKQPT-IGAFAM 387
Cdd:cd24076   232 GIGLANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAaLGAAAL 299
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 84-372 5.77e-62

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 202.01  E-value: 5.77e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  84 HSVAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVVE 163
Cdd:cd24073     2 YVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGICR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 164 YMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIG 243
Cdd:cd24073    82 WSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 244 HIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGyesslaniESITINDVCEHANLGDELAKQSLIRVGNQLGKA 323
Cdd:cd24073   162 HTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLRG--------EPLTIEDLLAAARAGDPAARAILRRAGRALGLA 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1447669362 324 IAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIV 372
Cdd:cd24073   234 LANLVNLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDLELV 282
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 83-387 3.11e-61

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 200.12  E-value: 3.11e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  83 FHSVAVRLGRDYIQLSLYNLGGKELASDYHEFH-YSHQTQLIEgLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGV 161
Cdd:cd24059     1 PYVIGVEIGRDLLSAVLCDLSGNILAREKYPLDeKENPEEVLE-KLYELIDRLLEKENIKSKILGIGIGAPGPLDVEKGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 162 VEYMPNI-AIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVG 240
Cdd:cd24059    80 ILNPPNFpGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 241 EIGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYesslaniesITINDVCEHANLGDELAKQSLIRVGNQL 320
Cdd:cd24059   160 EIGHTSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGSGR---------SFQLDIVEALQKGDPIADEVIEEAAKYL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1447669362 321 GKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQIDK-QPTIGAFAM 387
Cdd:cd24059   231 GIGLVNLINLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRILKSSLGEdAPLLGAAAL 298
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 84-376 2.90e-57

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 189.80  E-value: 2.90e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  84 HSVAVRLGRDYIQLSLYNLGGKELasDYHEFHYSHQTQ---LIEGLLFHLNTFIKQQqERIEQFIAIGIALPGLVNPETG 160
Cdd:cd24071     2 YIIGVKIEEGYLVLALTDLKGKIL--EKTRIPFDHETDpekVIELIAENIKKLIKNK-HVEKKLLGIGIAVSGLVDSKKG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 161 VVEYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVG 240
Cdd:cd24071    79 IVIRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 241 EIGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESSLANIESITINDVCEHANLGDELAKQSLIRVGNQL 320
Cdd:cd24071   159 EIGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKELTESYPLSLLKELEDFEIEKVREAAEEGDSVATELFKKAGEYL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 321 GKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQI 376
Cdd:cd24071   239 GIGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSL 294
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 146-375 1.66e-47

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 163.88  E-value: 1.66e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 146 AIGIALPGLVNPETGVVEYM-PNI-AIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGA 223
Cdd:cd24068    59 GIGISSAGQVDPKTGEVIYAtDNLpGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 224 GIIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIaqgyesslaNIESITINDVCEHAN 303
Cdd:cd24068   139 AIILDGRLYRGANGSAGELGHMVVDPGGRPCCCGGKGCLEQYASGTALVRRVAEAL---------GEPGIDGREIFDLAD 209

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1447669362 304 LGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQ 375
Cdd:cd24068   210 AGDPLAKEVVEEFAEDLATGLANLVHIFDPEVIVIGGGISAQGELFLEELREELRKLLMPPLLDATKIEPAK 281
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 142-372 1.02e-45

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 159.76  E-value: 1.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 142 EQFIAIGIALPGLVNPETGVVEYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGT 221
Cdd:cd24062    60 EDLIGIGVGVPGPVDVETGTVEVAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 222 GAGIIVNGQVFLGYNRNVGEIGHIQIDP-LGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESSLANI----ESITIN 296
Cdd:cd24062   140 GGGVIANGKIVHGANGAAGEIGHITVNPeGGAPCNCGKTGCLETVASATGIVRIAREELEEGKGSSALRIlalgGELTAK 219

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 297 DVCEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIV 372
Cdd:cd24062   220 DVFEAAKAGDELALAVVDTVARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKEYFDRFTFPRVRQDTEIV 295
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 86-387 8.17e-45

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 154.93  E-value: 8.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  86 VAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQ-LIEGLLFHLNTFIKQQQERiEQFIAIGIALPGLVNPETGVVEY 164
Cdd:cd23763     1 IGIDIGGTKIRAALVDLDGEILARERVPTPAEEGPEaVLDRIAELIEELLAEAGVR-ERILGIGIGVPGPVDPETGIVLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 165 MPNI-AIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIG 243
Cdd:cd23763    80 APNLpWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 244 HIQIdplgeqcqcgnfgcletvaanpaiisrvkkliaqgyesslaniesitINDVCEHanlgdelakqslirvgnqLGKA 323
Cdd:cd23763   160 HITV-----------------------------------------------LEEAARY------------------LGIG 174

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1447669362 324 IAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQI-DKQPTIGAFAM 387
Cdd:cd23763   175 LANLINLLNPELIVLGGGVAEAGDLLLEPIREAVRRRALPPLRRRVRIVPSELgDDAGLLGAAAL 239
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 84-355 1.17e-43

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 154.11  E-value: 1.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  84 HSVAVRLGRDYIQLSLYNLGGKELASD-YHEFHYSHQTQLIEGLLFHLNTFIKQQQERIEQfiaIGIALPGLVNPETGVV 162
Cdd:cd24072     2 WVLGIVVSPNSLRAQVGNACGELLGEFeYRVITLETPEALIDEIIDCIDRLLKLWKDRVKG---IALAIQGLVDSHKGVS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 163 EYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEI 242
Cdd:cd24072    79 LWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 243 GHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESslANIESITINDVCEHANLGDELAKQSLIRVGNQLGK 322
Cdd:cd24072   159 GHTKVNPDGARCDCGRRGCLETVASNSALKRNARVTLKLGPVS--ADPEKLTMEQLIEALEEGEPIATQIFDRAANAIGR 236

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1447669362 323 AIAMTINLFNPQKVVIAGQITAAQEIVFPAIQR 355
Cdd:cd24072   237 SLANILNLLNPEQVLLYGRGCRAGDLLLPAIRR 269
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 84-388 3.72e-43

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 152.31  E-value: 3.72e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  84 HSVAVRLGRDYIQLSLYNLGGKELASDYHEFHYSHQTQLIEGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETgvVE 163
Cdd:cd24077     2 YSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPKTPYGLVGIGIGIHGIVDENE--II 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 164 YMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFgaSKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIG 243
Cdd:cd24077    80 FTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERTF--SEDYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 244 HIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIaqgyesslaNIESITINDVCEHANLGDELAKQSLIRVGNQLGKA 323
Cdd:cd24077   158 HMIIVPNGKPCPCGNKGCLEQYASEKALLKELSEKK---------GLETLTFDDLIQLYNEGDPEALELIDQFIKYLAIG 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 324 IAMTINLFNPQKVVIAGQITAaqeiVFPAIQRNVENQSLKTFHTNLPIVASQIDKQPT-IGAFAMI 388
Cdd:cd24077   229 INNIINTFNPEIIIINSSLIN----EIPELLEKIKEQLSSSFNKYVEILISTLGKNATlLGGAAVA 290
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 142-376 1.60e-40

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 145.72  E-value: 1.60e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 142 EQFIAIGIALPGLVNPETGVVEYMPNIA-IDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRG 220
Cdd:cd24064    54 MELLGIGIGSPGSIDRENGIVRFSPNFPdWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 221 TGAGIIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQgYESSLA-NIESITINDVC 299
Cdd:cd24064   134 VGSGVICHGQLLTGYDGIAAELGHVIVEPNGPICGCGNRGCVEAFASATAIIRYARESRKR-YPDSLAgESEKINAKHVF 212

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1447669362 300 EHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKTFHTNLPIVASQI 376
Cdd:cd24064   213 DAARKNDPLATMVFRRVVDALAIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVMLSFQDTYSIELSNL 289
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 86-386 4.22e-37

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 136.70  E-value: 4.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362  86 VAVRLGRDYIQLSLYNLGGKELASDYHEF-HYSHQTQLIEGLLFHLNTFIKQqqERIEQFIAIGIALPGLVNPETGVVEY 164
Cdd:cd24063     3 VAVDIGGTWIRAGLVDEDGRILLKIRQPTpKTGDPGTVSEQVLGLIETLLSK--AGKDSIEGIGVSSAGPLDLRKGTIVN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 165 MPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGH 244
Cdd:cd24063    81 SPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVGH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 245 IQIDP-LGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESSLANI-----ESITINDVCEHANLGDELAKQSLIRVGN 318
Cdd:cd24063   161 LVVDTeSGLKCGCGGYGHWEAFASGRGIPRFAREWAEGFSSRTSLKLrnpggEGITAKEVFSAARKGDPLALKIIEKLAR 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 319 QLGKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLktfHTNLP-IVASQI-DKQPTIGAFA 386
Cdd:cd24063   241 YNGRGIANVINAYDPELIVIGGSVFNNNKDILDPLIEYLEKNPA---ISKGPeIVLSELgDDVGLIGALA 307
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 130-393 7.82e-36

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 133.49  E-value: 7.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 130 LNTFIKQQQERIEQFIAIGIALPGLVNPETGVVEYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDC 209
Cdd:TIGR00744  44 VDSFIQHIAKVGHEIVAIGIGAPGPVNRQRGTVYFAVNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 210 QDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGHIQIDPLGE-QCQCGNFGCLETVAANPAIISRVKKLIAQGYESS-- 286
Cdd:TIGR00744 124 RDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGHIRMVPDGRlLCNCGKQGCIETYASATGLVRYAKRANAKPERAEvl 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 287 --LANIESITINDVCEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQSLKT 364
Cdd:TIGR00744 204 laLGDGDGISAKHVFVAARQGDPVAVDSYREVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSYKRWLFGG 283

                         250       260       270
                  ....*....|....*....|....*....|
gi 1447669362 365 FHTNLPIVASQI-DKQPTIGAFAMIKRAML 393
Cdd:TIGR00744 284 ARQVADIIAAQLgNDAGLVGAADLARTYII 313
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 144-354 1.83e-35

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 132.48  E-value: 1.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 144 FIAIGIALPGLVNPETGVVEYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGA 223
Cdd:cd24061    54 VSAVGVAAAGFVDADRATVLFAPNIAWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 224 GIIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGYESS-----LANIESITINDV 298
Cdd:cd24061   134 GIVIGGKLLRGAFGIAGEFGHIRVVPDGLLCGCGSRGCWEQYASGRALVRYAKEAANATPEGAavllaDGSVDGITGKHI 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 299 CEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQ 354
Cdd:cd24061   214 SEAARAGDPVALDALRELARWLGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIR 269
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 147-387 8.29e-30

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 117.13  E-value: 8.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 147 IGIALPGLVNPETGVVEYMPNIAID--ALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAG 224
Cdd:cd24060    63 VGISTGGRVNPREGIVLHSTKLIQEwsSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 225 IIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAANPAIISRVKKLIAQGY----ESSLANIESITINDVCE 300
Cdd:cd24060   143 IILNHELIHGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMALQREAKKLHDEDLllveGMSVTNDEEVTAKHLIQ 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 301 HANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQE-IVFPAIQRnvenQSLKTFhTNLPIVASQIDKQ 379
Cdd:cd24060   223 AAKLGNAKAQKILRTAGTALGLGIVNILHTLNPSLVILSGVLASHYEnIVKDVIAQ----RALPSV-QNVDVVVSDLVDP 297


                  ....*...
gi 1447669362 380 PTIGAFAM 387
Cdd:cd24060   298 ALLGAASM 305
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 122-344 2.80e-28

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 112.64  E-value: 2.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 122 LIEGLLFHLNTFIKQQQERIEqfiAIGIALPGLVNPETGVVEYMPNI-AIDALALGDIIRDNFHVECFVGNDVRGMALAE 200
Cdd:cd24070    41 PVEVLADLIREYIEEAGLKPA---AIVIGVPGTVDKDRRTVISTPNIpGLDGVNLADILENKLGIPVILERDVNLLLLYD 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 201 HYFGASKDcqDSILVSVHRGTGAG--IIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAANPAIisrvKKL 278
Cdd:cd24070   118 MRAGNLDD--EGVVLGFYIGTGIGnaILINGKPLRGKNGVAGELGHIPVYGNGKPCGCGNTGCLETYASGRAL----EEI 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 279 IAQGYesslaniESITINDVCEHANLGDELakQSLIRvgnQLGKAIAMTINLFNPQKVVIAGQITA 344
Cdd:cd24070   192 AEEHY-------PDTPILDIFVDHGDEPEL--DEFVE---DLALAIATEINILDPDAVILGGGVID 245
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 124-361 9.97e-28

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 110.88  E-value: 9.97e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 124 EGLLFHLNTFIKQQQERIEQFIAIGIALPGLVNPETGVVEYMPNI-AIDALALGDIIRDNFHVECFVGNDVRGMALAEHY 202
Cdd:cd24065    36 EAVLDALARAVEALQAEAPGVEAVGLGVPGPLDFRRGRVRFAPNIpGLTDFPIRRGLAERLGLPVVLENDANAAALAEHH 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 203 FGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAANPAIISrvkkliaqg 282
Cdd:cd24065   116 YGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIGHTTVLPGGPMCGCGLVGCLEALASGRALAR--------- 186

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1447669362 283 yESSLANIESITINDVCEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEIVFPAIQRNVENQS 361
Cdd:cd24065   187 -DASFAYGRPMSTAELFELAQQGEPKALRIVEQAAAHLGIGLANLQKALDPEVFVLGGGVAQVGDYYLLPVQEAARRYT 264
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 134-358 2.11e-24

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 101.49  E-value: 2.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 134 IKQQQERIEqfiAIGIALPGLVNPETGVVEYM-PNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDS 212
Cdd:cd24152    47 IKRYDEEID---GIAISAPGVIDPETGIIYGGgALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNG 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 213 ILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQcgNFGCLetvAANPAIISRVKKliaqgyessLANIES 292
Cdd:cd24152   124 AVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTDDDDKDLL--FFSGL---ASMFGLVKRYNK---------AKGLEP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447669362 293 ITINDVCEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITaAQEIVFPAIQRNVE 358
Cdd:cd24152   190 LDGEEIFEKYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGGGIS-EQPLFIEDLKKEVN 254
PRK09698 PRK09698
D-allose kinase; Provisional
 118-356 4.69e-20

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 89.66  E-value: 4.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 118 HQTQ--LIEGLLFHLNTFIKQQQERIEQFI-AIGIALPGLVNPETGVVEYMPNI---AIDALALGDIIRDNFHVECFVGN 191
Cdd:PRK09698   33 KRTAevIAPDLVSGLGEMIDEYLRRFNARChGIVMGFPALVSKDRRTVISTPNLpltALDLYDLADKLENTLNCPVFFSR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 192 DVRGMAL--AEHYfgaskDCQDSILVSVHRGTGAG--IIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAA 267
Cdd:PRK09698  113 DVNLQLLwdVKEN-----NLTQQLVLGAYLGTGMGfaVWMNGAPWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCS 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 268 NPAiISRVkkliaqgYESSLANiesITINDVCEHAnlGDELAKQSLIrvgNQLGKAIAMTINLFNPQKVVIAGQITAAQE 347
Cdd:PRK09698  188 GMA-LRRW-------YEQQPRD---YPLSDLFVHA--GDHPFIQSLL---ENLARAIATSINLFDPDAIILGGGVMDMPA 251

                         250
                  ....*....|....*
gi 1447669362 348 ivFP------AIQRN 356
Cdd:PRK09698  252 --FPretliaMIQKY 264
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 147-349 3.54e-18

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 84.21  E-value: 3.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 147 IGIALPGLVNPETGVVeYMPNI-AIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDcQDSIL-VSVHRGTGAG 224
Cdd:cd24057    60 VGIGIPGVIDPEDGTL-ITANIpAAKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRG-YPSVFgLILGTGVGGG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 225 IIVNGQVFLGYNRNVGEIGH--IQIDPLGEQ-------CQCGNFGCLETVAANPAiisrVKKLIAQGYESSLANIESIti 295
Cdd:cd24057   138 LVVNGRLVGGRSGIAGEWGHgpLPADALLLGydlpvlrCGCGQTGCLETYLSGRG----LERLYAHLYGEELDAPEII-- 211

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1447669362 296 ndvcEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEIV 349
Cdd:cd24057   212 ----AAWAAGDPQAVAHVDRWLDLLAGCLANILTALDPDVVVLGGGLSNFPALI 261
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 141-342 1.14e-17

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 82.33  E-value: 1.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 141 IEQFIAIGIALPGLVNpeTGVVEYMPNIAI---DALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSV 217
Cdd:cd24069    49 QGQFDRVAVASTGIIR--DGVLTALNPKNLgglSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITV 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 218 HRGTGAGIIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVAANPAIisrvkkliaqGYESSLANIESITIND 297
Cdd:cd24069   127 STGVGGGLVLNGQLLTGPNGLAGHIGHTLADPPGPVCGCGRRGCVEAIASGTAI----------AAAASEILGEPVDAKD 196

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1447669362 298 VCEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQI 342
Cdd:cd24069   197 VFERARSGDEEAARLIDRAARALADLIADLKATLDLDCVVIGGSV 241
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 116-340 2.84e-17

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 81.48  E-value: 2.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 116 YSHQTQLIEGLlfhlntfIKQQQERIEQFIAIGIALPGLVNPETGVVEYMPNIAIDALALGDIIRDNFHVECFVGNDVRG 195
Cdd:cd24066    35 YEATLDAIADL-------VEEAEEELGAPATVGIGTPGSISPRTGLVKNANSTWLNGKPLKADLEARLGRPVRIENDANC 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 196 MALAEHYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGHIQIDPL------GEQCQCGNFGCLETVAANP 269
Cdd:cd24066   108 FALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGEWGHNPLPWPdedelpGPPCYCGKRGCVETFLSGP 187

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447669362 270 AIISRVKKLIAqgyesslaniESITINDVCEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAG 340
Cdd:cd24066   188 ALERDYARLTG----------KTLSAEEIVALARAGDAAAVATLDRFLDRLGRALANVINILDPDVIVLGG 248
PRK09557 PRK09557
fructokinase; Reviewed
 147-348 2.42e-14

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 73.14  E-value: 2.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 147 IGIALPGLVNPETGVVEYMPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGTGAGII 226
Cdd:PRK09557   60 VGVGIPGSISPYTGLVKNANSTWLNGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 227 VNGQVFLGYNRNVGEIGHiqiDPL------------GEQCQCGNFGCLETVAANPAIISRVKKLIAQgyesSLANIESIT 294
Cdd:PRK09557  140 INGRVHIGGNGIAGEWGH---NPLpwmdedelryrnEVPCYCGKQGCIETFISGTGFATDYRRLSGK----ALKGSEIIR 212

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1447669362 295 INDVcehanlGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAGQITAAQEI 348
Cdd:PRK09557  213 LVEE------GDPVAELAFRRYEDRLAKSLAHVINILDPDVIVLGGGMSNVDRL 260
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 187-342 3.08e-13

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 69.56  E-value: 3.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 187 CFVGNDVRGMALAEhYFGASKDCQDSILVSVHRGTGAGIIVNGQVFLGYNRNVGEIGHIQIDPLGEQCQCGNFGCLETVA 266
Cdd:PRK05082  100 TIALNDAQAAAWAE-YQALPDDIRNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHGPVCGCGRRGCVEAIA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 267 ANPAiisrvkklIAQGYESSLANIESitiNDVCEHANLGDELAkQSLIrvgNQLGKAIA-----MTINLfNPQKVVIAGQ 341
Cdd:PRK05082  179 SGRA--------IAAAAQGWLAGCDA---KTIFERAGQGDEQA-QALI---NRSAQAIArliadLKATL-DCQCVVLGGS 242


                  .
gi 1447669362 342 I 342
Cdd:PRK05082  243 V 243
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 147-340 1.13e-11

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 65.01  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 147 IGIALPGLVNPETGVVeYMPNIAIdalALGDIIRDNFHV----ECFVGNDVRGMALAEHYfgASKDCQDSILVSVHRGTG 222
Cdd:PRK13310   60 VGIGIPGMPETEDGTL-YAANVPA---ASGKPLRADLSArlgrDVRLDNDANCFALSEAW--DDEFTQYPLVMGLILGTG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 223 --AGIIVNGQVFLGYNRNVGEIGHIQI-----DPLGE-----QCQCGNFGCLETVaanpaiisrvkkLIAQGYESSLANI 290
Cdd:PRK13310  134 vgGGLVFNGKPISGRSYITGEFGHMRLpvdalTLLGWdaplrRCGCGQKGCIENY------------LSGRGFEWLYQHY 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1447669362 291 --ESITINDVCEHANLGDELAKQSLIRVGNQLGKAIAMTINLFNPQKVVIAG 340
Cdd:PRK13310  202 ygEPLQAPEIIALYYQGDEQAVAHVERYLDLLAICLGNILTIVDPHLVVLGG 253
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 133-357 2.91e-09

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 57.55  E-value: 2.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 133 FIKQQQERIEqfiAIGIALPGLVNPETGVVEY-----MPNIAIDALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASK 207
Cdd:cd24067    43 FFREQEEPID---AIGIASFGPIDLNPTSPTYgyittTPKPGWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAK 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 208 DCQDSILVSVHRGTGAGIIVNGQVFLGynRNVGEIGHIQIDPLGEQ------CQCGNfGCLETVAANPAIISRVKKliaq 281
Cdd:cd24067   120 GLDSLAYITVGTGIGVGLVVNGKPVHG--LLHPEMGHIRVPRHPDDdgfpgvCPFHG-DCLEGLASGPAIAARWGI---- 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1447669362 282 gyesslaniesitindvcehanLGDELAKQSLIR--VGNQLGKAIAMTINLFNPQKVVIAGQItAAQEIVFPAIQRNV 357
Cdd:cd24067   193 ----------------------PAEELPDDHPAWdlEAYYLAQACANLTLTLSPERIVLGGGV-MQRPGLFPRIREKF 247
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 146-263 2.62e-07

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 51.57  E-value: 2.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 146 AIGIALPGLVNPETGVVeYMPNIAIdalALGDIIRDNF----HVECFVGNDVRGMALAEHYFGASKDCQDSILVSVHRGT 221
Cdd:PRK13311   59 SVGIGIPGLPNADDGTV-FTANVPS---AMGQPLQADLsrliQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGV 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1447669362 222 GAGIIVNGQVFLGYNRNVGEIGHIQ-----IDPLGEQ-----CQCGNFGCLE 263
Cdd:PRK13311  135 GGGLIVNGSIVSGRNHITGEFGHFRlpvdaLDILGADiprvpCGCGHRGCIE 186
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 134-248 2.08e-05

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 45.64  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362 134 IKQQQERIEQFIAIGIALPGLVnpETGVVEYMPNIAID--ALALGDIIRDNFHVECFVGNDVRGMALAEHYFGASKDCQD 211
Cdd:cd24058    45 VAELVAHFPWFGPVGVGFPGVV--RRGVVRTAANLDKSwiGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKG 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1447669362 212 SILVsVHRGTGAG--IIVNGQvfLGYNRnvgEIGHIQID 248
Cdd:cd24058   123 VVLV-LTLGTGIGsaLFVDGH--LVPNT---ELGHLEIR 155
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
22-102 7.52e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 41.43  E-value: 7.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447669362   22 RLIDLQGPISRIQVADVSQLAPASVTKITRQLLERGLIkevAQQASTGGRRA--ISLTTEVAPFHSVAVRLGRDYIQLSL 99
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV---RREPSPEDRRSvlVSLTEEGRELIEQLLEARSETLAELL 93


                   ...
gi 1447669362  100 YNL 102
Cdd:smart00347  94 AGL 96
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 22-74 1.12e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 36.76  E-value: 1.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1447669362  22 RLIDLQGPISRIQVADVSQLAPASVTKITRQLLERGLIKevaQQASTGGRRAI 74
Cdd:pfam01047  10 RILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE---RSRSPEDRREV 59
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
19-79 1.55e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 38.65  E-value: 1.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447669362  19 AVYRLIDLQGPISRIQVADVSQLAPASVTKITRQLLERGLIKEVaqqastgGRRAISLTTE 79
Cdd:COG1321    14 AIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYE-------PYGGITLTEE 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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