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Conserved domains on  [gi|1434114610|gb|AXF85595|]
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Purine efflux pump PbuE [Ephemeroptericola cinctiostellae]

Protein Classification

MFS transporter( domain architecture ID 11457990)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0005886|GO:0016020|GO:0022857|GO:0055085
PubMed:  26098515|9529885|26758938|23403214
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-292 5.85e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


:

Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 135.49  E-value: 5.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:COG2814    67 RLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFlKQPNIIRMYILQALNQFSAFL 168
Cdd:COG2814   147 PALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL-RRPRLLLLLLLAFLLGFGFFA 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 169 IIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFnALPIWLTLVCFV 248
Cdd:COG2814   226 LFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-AGSLWLLLLALF 304

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1434114610 249 AFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLA 292
Cdd:COG2814   305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-292 5.85e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 135.49  E-value: 5.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:COG2814    67 RLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFlKQPNIIRMYILQALNQFSAFL 168
Cdd:COG2814   147 PALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL-RRPRLLLLLLLAFLLGFGFFA 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 169 IIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFnALPIWLTLVCFV 248
Cdd:COG2814   226 LFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-AGSLWLLLLALF 304

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1434114610 249 AFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLA 292
Cdd:COG2814   305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 2-326 5.65e-35

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 130.75  E-value: 5.65e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKI 81
Cdd:cd17324    53 LLGPLS----DRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  82 MTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDAS-AYFLKQPNIIRMYILQA 160
Cdd:cd17324   129 FSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSlLLLLRNPRLRLAYLITF 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 161 LNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIyATGLFAFSFNALPI 240
Cdd:cd17324   209 LLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLL-AAALLLLTLLGPSP 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 241 WLTLVCFVAFMAGNAGRNISLTTSSSRIPePSFRARYMTFQGFVRDASITLASVLSSTVLntQNNGYIENMPILIALSLL 320
Cdd:cd17324   288 LLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVL--DHGGWAGVGWVGAALLLL 364


                  ....*.
gi 1434114610 321 TALYVL 326
Cdd:cd17324   365 ALLLAL 370
MFS_1 pfam07690
Major Facilitator Superfamily;
9-293 1.12e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.02  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:pfam07690  54 RLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQPNIIR----MYILQALNQF 164
Cdd:pfam07690 134 AALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRdpvlWLLLALLLFG 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 165 SAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSF--NALPIWL 242
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlsLTLSSLW 293

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1434114610 243 TLVCFVAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLAS 293
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
1-130 1.48e-18

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 80.77  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:TIGR00880  12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGL 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSS 130
Cdd:TIGR00880  92 MSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK03545 PRK03545
putative arabinose transporter; Provisional
 13-132 4.96e-15

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 75.31  E-value: 4.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  13 RYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLATVLG 92
Cdd:PRK03545   70 NVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLG 149

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1434114610  93 VPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF---KLPSSNS 132
Cdd:PRK03545  150 LPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKllpLLPSEHS 192
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-292 5.85e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 135.49  E-value: 5.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:COG2814    67 RLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFlKQPNIIRMYILQALNQFSAFL 168
Cdd:COG2814   147 PALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL-RRPRLLLLLLLAFLLGFGFFA 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 169 IIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFnALPIWLTLVCFV 248
Cdd:COG2814   226 LFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-AGSLWLLLLALF 304

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1434114610 249 AFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLA 292
Cdd:COG2814   305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 2-326 5.65e-35

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 130.75  E-value: 5.65e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKI 81
Cdd:cd17324    53 LLGPLS----DRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  82 MTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDAS-AYFLKQPNIIRMYILQA 160
Cdd:cd17324   129 FSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSlLLLLRNPRLRLAYLITF 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 161 LNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIyATGLFAFSFNALPI 240
Cdd:cd17324   209 LLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLL-AAALLLLTLLGPSP 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 241 WLTLVCFVAFMAGNAGRNISLTTSSSRIPePSFRARYMTFQGFVRDASITLASVLSSTVLntQNNGYIENMPILIALSLL 320
Cdd:cd17324   288 LLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVL--DHGGWAGVGWVGAALLLL 364


                  ....*.
gi 1434114610 321 TALYVL 326
Cdd:cd17324   365 ALLLAL 370
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-326 1.34e-27

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 110.74  E-value: 1.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:cd17325    49 PPAGRLS----DRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGI 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDAS-----AYFLKQPNIIRM 155
Cdd:cd17325   125 FSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARlrsglRLLLRDRRLLAL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 156 YILQALNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSF 235
Cdd:cd17325   205 FLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 236 nALPIWLTLVCFVAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVlnTQNNGYIENMPILI 315
Cdd:cd17325   285 -ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL--YDAFGFATPFLAAA 361

                         330
                  ....*....|.
gi 1434114610 316 ALSLLTALYVL 326
Cdd:cd17325   362 ALLLLAAVLFL 372
MFS_1 pfam07690
Major Facilitator Superfamily;
9-293 1.12e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.02  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:pfam07690  54 RLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQPNIIR----MYILQALNQF 164
Cdd:pfam07690 134 AALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRdpvlWLLLALLLFG 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 165 SAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSF--NALPIWL 242
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlsLTLSSLW 293

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1434114610 243 TLVCFVAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLAS 293
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 2-327 3.20e-19

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 87.25  E-value: 3.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKI 81
Cdd:cd17320    53 LYGPLS----DRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  82 MTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEP--EKKDASAYF--LKQPNIIRMYI 157
Cdd:cd17320   129 MMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKplLSSLLRAYKrvLKNRRFLGYAL 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 158 LQALNqFSAFLIIPTLSAYLMFN-FAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFN 236
Cdd:cd17320   209 ALGLS-FAGLFAYLAAAPFIYIEqLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLA 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 237 ALPIWLTLVCFVAFMAGNAGRN---ISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVLntqnNGYIENMPI 313
Cdd:cd17320   288 ALLGGLSLWPLVAPLFLIFFGFgliFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLP----NGTALPMGL 363

                         330
                  ....*....|....
gi 1434114610 314 LIALSLLTALYVLY 327
Cdd:cd17320   364 LILVLGLLALLLLI 377
2_A_01_02 TIGR00880
Multidrug resistance protein;
1-130 1.48e-18

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 80.77  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:TIGR00880  12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGL 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSS 130
Cdd:TIGR00880  92 MSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
10-253 5.18e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 81.08  E-value: 5.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLAT 89
Cdd:COG2223    63 LVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGA 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  90 VLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYF--LKQPNIIRMYILQALNQFSAF 167
Cdd:COG2223   143 AVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLeaLRDPRFWLLSLLYFGTFGSFI 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 168 LIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFNALPIWLTLVCF 247
Cdd:COG2223   223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLF 302


                  ....*.
gi 1434114610 248 VAFMAG 253
Cdd:COG2223   303 LLLGLA 308
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 10-332 6.68e-17

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 80.70  E-value: 6.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLAT 89
Cdd:cd17503    54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  90 VLGVPLVLTLSEQYGWQYCFLL---IGLLAVVLyvytyfklpssNSVLDepekkdasAYFLKQPNIIRMYILQALNQFSA 166
Cdd:cd17503   134 AIGPTLGGWLTDNLSWRWIFYInlpIGILALLL-----------APLLD--------LRLFKDRNFTLGLLLSFLLGLGL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 167 FLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYA--TGLFAFSFNALPIWLTL 244
Cdd:cd17503   195 FGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAlgTLLLAFLTPDTSLWLII 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 245 VCFVAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVLNTQNNGYIENMPILIALSLLTALY 324
Cdd:cd17503   275 LPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQVQKQAL 354


                  ....*...
gi 1434114610 325 VLYAHHTW 332
Cdd:cd17503   355 IIAFNDAF 362
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
10-323 1.16e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 79.91  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLAT 89
Cdd:COG2271    68 LADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  90 VLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYtyfklpssnsvldepekkdasayflkqpNIIRMYILQALNQFSAFLI 169
Cdd:COG2271   148 ALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------------------------RFWLLALAYFLVYFALYGF 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 170 IPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIAD--NKSTDMTLFLGTTIYATGLFAFSFnALPIWLTLVCF 247
Cdd:COG2271   200 LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAALALLLLAL-LPSPALAIALL 278

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1434114610 248 VAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVLntQNNGYIENMPILIALSLLTAL 323
Cdd:COG2271   279 FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL--DATGYQAAFLLLAALALLAAL 352
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 1-333 4.70e-16

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 77.98  E-value: 4.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:cd17321    49 LLAGRLG----DRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVytyfklpssnsvldepekkdasayflkqpnIIRMYILQA 160
Cdd:cd17321   125 WGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL------------------------------LARTFSGAV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 161 LNQFSAFLIIPTLSAYLMFNFAIEREYLP----YFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSF- 235
Cdd:cd17321   175 LAAFLLGAALGGLLFLLPLYLQGVLGYSPlqagLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALl 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 236 -NALPIWLTLVCFVAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVLNTQNNGYIENMPIL 314
Cdd:cd17321   255 gADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVA 334

                         330
                  ....*....|....*....
gi 1434114610 315 IALSLLTALYVLYAHHTWF 333
Cdd:cd17321   335 ALLSAAAAAFAAGFHLAFL 353
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-326 1.47e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 76.70  E-value: 1.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:cd06174    45 ALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  81 IMTGFTLATVLGVPLV--LTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPS-------SNSVLDEPEKKDASAYFLKQPN 151
Cdd:cd06174   125 LQAFGSVGGILGPLLGgiLASSLGFGWRAVFLIAAALALLAAILLLLVVPDppesaraKNEEASSKSVLKLLKRVLKNPG 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 152 IIRMYILQALNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLF 231
Cdd:cd06174   205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 232 AFSFNALPIWLTLVCFVAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVLNTQNNGYIENM 311
Cdd:cd06174   285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFL 364

                         330
                  ....*....|....*
gi 1434114610 312 pILIALSLLTALYVL 326
Cdd:cd06174   365 -VLAVLLLLAAILLL 378
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 2-328 1.94e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 76.46  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKI 81
Cdd:cd17474    53 VAGVLA----DRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLY 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  82 MTGFTLATVLGvPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSnsvldEPEKKDASAYFLKQPNIIRMYILQAL 161
Cdd:cd17474   129 EAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP-----KEKAKSSSATKLRDLKKALRGRGLLT 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 162 NQFSAFLIIPTLSAYLMFN-FAIEREYLPYFYLLGGVVSF------ITIHTLGRIADNK-STDMTLFLGTTIYATGLFAF 233
Cdd:cd17474   203 FLVSAFLYFFLYFAFLTYLpFLLELLYGISPIIIGLLFAGwsvllaLGSLFVGRLLKKRfGARRILVIGLLLYALSLLLL 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 234 SFnALPIWLTLVCFVAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVLNTQNngyIENMPI 313
Cdd:cd17474   283 GF-VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG---LSAPFL 358

                         330
                  ....*....|....*
gi 1434114610 314 LIALSLLTALYVLYA 328
Cdd:cd17474   359 VGAAIALAAAVLLAL 373
PRK03545 PRK03545
putative arabinose transporter; Provisional
 13-132 4.96e-15

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 75.31  E-value: 4.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  13 RYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLATVLG 92
Cdd:PRK03545   70 NVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLG 149

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1434114610  93 VPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF---KLPSSNS 132
Cdd:PRK03545  150 LPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKllpLLPSEHS 192
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-328 1.66e-14

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 73.42  E-value: 1.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLL-SSWGVFALSTLMCAWA----QNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLG 75
Cdd:cd06173    48 LLFSPFAGVLADRFDRRRLLIlADLLRALLAAVLALLAllgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLV 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  76 RVMAKIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF------KLPSSNSVLDEPEKKDASAYFLKQ 149
Cdd:cd06173   128 RANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFirrpppAAPGESSSLLLRDLREGLRYLRRS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 150 PNIIRMYILQALNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATG 229
Cdd:cd06173   208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 230 LFAFSFnALPIWLTLVCFVAFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVLNTqnngyIE 309
Cdd:cd06173   288 LLVLGL-SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA-----LG 361

                         330
                  ....*....|....*....
gi 1434114610 310 NMPILIALSLLTALYVLYA 328
Cdd:cd06173   362 LSAVFLLAGALLLLAALLL 380
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 12-235 6.34e-14

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 71.00  E-value: 6.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLATVL 91
Cdd:COG0477    74 DRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  92 GVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPekkdASAYFLKQPNIIRMYILQALNQFSAFLIIP 171
Cdd:COG0477   154 GPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALL----ALALAALLLAALALALLALLLLLLLLLLAL 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1434114610 172 TLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSF 235
Cdd:COG0477   230 LALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 9-120 2.67e-12

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 66.82  E-value: 2.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:cd17502    52 KLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIA 131

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLL---IGLLAVVLY 120
Cdd:cd17502   132 SVAGPLIGGAFTDHLSWRWCFYInlpIGGLALALL 166
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 12-253 4.28e-12

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 66.47  E-value: 4.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGaSGSMAlSIAMAIAIDITPPHHLGRVMAKIMTGFTLATVL 91
Cdd:cd17472    57 DRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAI 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  92 GVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEK-KDASAYFLKQPNIIRMYILQALNQF---SAF 167
Cdd:cd17472   135 SMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKeKKKLKKLLKNKRLLRLDFSIFILHFvlmAFF 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 168 LIIPTLSAYLMFnfaiEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFL-GTTIYATGLFAFSFNALPIWLTLVC 246
Cdd:cd17472   215 YILPLLLTQLGG----GKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVsSILLIAVGFLLLLFAATSLWLLIIG 290


                  ....*..
gi 1434114610 247 FVAFMAG 253
Cdd:cd17472   291 LIIFFIG 297
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 2-327 4.73e-12

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 66.06  E-value: 4.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSmALSIAMAIAIDITPPHHLGRVMAKI 81
Cdd:cd17330    53 LWGRLS----DRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGII 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  82 MTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSsnsvldepekkdasayflkqpnIIRMYILQAL 161
Cdd:cd17330   128 SAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP----------------------LRRLLLVYFL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 162 NQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVS-FITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFNALPI 240
Cdd:cd17330   186 IALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGiLAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 241 WLTLVCFVaFMAGNAGRNISLTTSSSRIPEPSFRARYMTFQGFVRDASITLASVLSSTVLNTQNNGyienMPILI-ALSL 319
Cdd:cd17330   266 LLVLAAAI-LAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG----VPFLLaAGLL 340


                  ....*...
gi 1434114610 320 LTALYVLY 327
Cdd:cd17330   341 LIALFLLS 348
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 1-119 1.26e-11

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 64.91  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFI-DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMA 79
Cdd:cd17365    47 MAIGALLAGPLaDRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVT 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1434114610  80 KIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVL 119
Cdd:cd17365   127 LMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLIL 166
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 9-263 2.90e-11

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 63.75  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMaLSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:cd17504    53 RLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIG 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFklpssnsvldepekkdASAYFLKQPNIIRMYILQALNQFSAFL 168
Cdd:cd17504   132 AGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPL----------------IDLRLLRRRNVLLANITALLAGFGMFM 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 169 IIPTLSAYL------MFNFAIEREYLpyFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFNALPIWL 242
Cdd:cd17504   196 VFQLLPQLLqlptptGFGLGITEAGL--LLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWA 273

                         250       260
                  ....*....|....*....|.
gi 1434114610 243 TLVCFVAFMAGNAGRNISLTT 263
Cdd:cd17504   274 LVVALLLIGIGLGLAFASLPN 294
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 11-245 2.90e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.77  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  11 IDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLATV 90
Cdd:cd17489    55 LDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMA 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  91 LGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQPNIIRMYILQALNQFSAFLII 170
Cdd:cd17489   135 LGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIS 214

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1434114610 171 PTLSAYLMfnfAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFNALPIWLTLV 245
Cdd:cd17489   215 TFLPLYAA---ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA 286
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
10-300 1.09e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 62.23  E-value: 1.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRYN-----RRTLLLSSWGVFALSTLMCAWAQNFQQ------LFFTRALVGASGSMALSIAMAIAIDITP-PHHLGRV 77
Cdd:COG2211    69 LSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  78 MAKIMTGFTLATVLGVPLVLTL------SEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEK-KDASAYFLKQP 150
Cdd:COG2211   149 SSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSlKESLKALLKNR 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 151 NIIRMYILQALNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGL 230
Cdd:COG2211   229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1434114610 231 FAFSF-NALPIWLTLVCFVAFMAGNAGRNISLTTSSSRIPEPS-------FRARYMTFQGFVRDASITLASVLSSTVL 300
Cdd:COG2211   309 LLLFFlGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLL 386
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-130 3.41e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 60.83  E-value: 3.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFI-DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMA 79
Cdd:TIGR00895  65 MAFGALFFGPLaDRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVG 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1434114610  80 KIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSS 130
Cdd:TIGR00895 145 LMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPES 195
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 10-129 4.62e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 59.89  E-value: 4.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLAT 89
Cdd:cd17319    61 LLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGA 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1434114610  90 VLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPS 129
Cdd:cd17319   141 AIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ 180
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 2-323 5.52e-10

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 59.93  E-value: 5.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKI 81
Cdd:cd17329    50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  82 MTGFTLATVLGvPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNS---VLDEPEKKDASAYFLKQPNIIRMYIL 158
Cdd:cd17329   130 YWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPkrrAAEKTEILRGYKIVLRDRAFLLFLLA 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 159 QALNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFNAL 238
Cdd:cd17329   209 SFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 239 PIWLTLVCFVAFMAGNAGRNISLTTSSSRIPEPSfRARYMTFQGFVRDASITLASVLSSTVLNtqNNGYIENMPILIALS 318
Cdd:cd17329   289 LAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDK-RGSYMGFYALAWGLGRAIGPLVGGLLLD--LLGPGLPWLILAALG 365


                  ....*
gi 1434114610 319 LLTAL 323
Cdd:cd17329   366 LIAAA 370
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 9-127 6.40e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.90  E-value: 6.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:cd17325   257 KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLG 336

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKL 127
Cdd:cd17325   337 MVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 9-254 1.73e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 58.35  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:cd17473    57 WLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLG 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEqYGWQYCFLLIgLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQPNIIRMYILQALNQFSAFL 168
Cdd:cd17473   137 GVVFLLLGGALAE-IGWRAPFLVY-LLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFY 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 169 IIPTLSAYLMFNFAIEREYLPYFYL-LGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFnALPIWLTLVCF 247
Cdd:cd17473   215 VIPIQLPFLLQERGGGSAALIGLALaIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL-ASGLWVVLLGA 293


                  ....*..
gi 1434114610 248 VAFMAGN 254
Cdd:cd17473   294 ILAGLGF 300
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 1-131 3.00e-09

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 57.78  E-value: 3.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:TIGR00710  58 LLWGPLS----DRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSI 133

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSN 131
Cdd:TIGR00710 134 LMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETL 184
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-126 8.26e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 56.47  E-value: 8.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSL-KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMA 79
Cdd:cd06173   257 ALLGALLLgRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFS 336

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1434114610  80 KIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFK 126
Cdd:cd06173   337 VYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 12-142 8.36e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 56.48  E-value: 8.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVG---ASGSmalSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:cd17328    59 DRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGigeASYS---PIAPTIIADLFPKEKRTRALGVFYFAIPLG 135

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1434114610  89 TVLGVPL-VLTLSEQYGWQYCFLLIGLLAVVLYVYTYFklpssnsVLDEPEKKDA 142
Cdd:cd17328   136 SGLGYVVgGLVAQATGGWRWAFRVTGVLGVLLAILLLL-------FVREPPRGAA 183
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 1-128 9.37e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 56.04  E-value: 9.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:cd17323    52 LIWAPLS----ELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGV 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLP 128
Cdd:cd17323   128 YSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-256 1.40e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.69  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFI-DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPH----HLG 75
Cdd:cd17316    49 RPIGALLFGYLgDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKrrgfALG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  76 RVMAKIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYtyfklpssnsvldepekkdasayflkQPNIIRM 155
Cdd:cd17316   129 LLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL--------------------------RRRTLLL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 156 YILQALNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSF 235
Cdd:cd17316   183 ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFY 262

                         250       260
                  ....*....|....*....|..
gi 1434114610 236 N-ALPIWLTLVCFVAFMAGNAG 256
Cdd:cd17316   263 LlSGSPTLLLLLLFILSFFVGG 284
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-127 3.79e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.14  E-value: 3.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:cd17489   241 LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKL 127
Cdd:cd17489   321 FFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 12-182 9.99e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 53.07  E-value: 9.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFT----L 87
Cdd:cd17371    59 DRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlL 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  88 ATVLGVPLVLTLSEQYGWQYCFLLiGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQPNIirmyilqalnqFSAF 167
Cdd:cd17371   139 ATLLAALLFPLLPPEIAWRVLFLL-GALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLREL-----------FSPP 206

                         170
                  ....*....|....*
gi 1434114610 168 LIIPTLSAYLMFNFA 182
Cdd:cd17371   207 LLRTTLLASLLATGA 221
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 10-262 2.18e-07

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 51.89  E-value: 2.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAM-AIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:cd17355    61 LLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYV---YTYFKLPSSNSVLDEPEKKDAS-AYFLKQ----PNIIRMYILQA 160
Cdd:cd17355   141 SLVFLPLGAALIEAFGWRTALLVLALLALLVLVpvlLLLRRRPADLALRAYDDASPASpGSTLKEalrsASFWLLALAFF 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 161 LNQFSAFLIIPTLSAYLMfNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSFNALPI 240
Cdd:cd17355   221 LCGFAVVGLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPP 299

                         250       260
                  ....*....|....*....|..
gi 1434114610 241 WLTLVcFVAFMAGNAGRNISLT 262
Cdd:cd17355   300 LALLL-FAALFGLGWGATVPLT 320
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 2-255 3.71e-07

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 51.07  E-value: 3.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSmALSIAMAIAIDITP----PHHLGRV 77
Cdd:cd17390    50 LVGSWS----DVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKH-TQSLCKAYLSDLVSeqerSRVLGRF 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  78 MAKIMTGFTLATVLGVPLVLTlseQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLdepekkdasayflkqpniirmyI 157
Cdd:cd17390   125 NAASSLGFILGPVVGGHLAET---DGGFYYVALLCSAIFILNAGLVWFLLSKLWDLL----------------------L 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 158 LQALNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIAD-NKSTDMTLFLGTTIYATGLFAFSFN 236
Cdd:cd17390   180 VRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKlYKNNEYLLLLHSFILLALSLLGLAL 259

                         250
                  ....*....|....*....
gi 1434114610 237 ALPIWLTLVCFVAFMAGNA 255
Cdd:cd17390   260 APSIWLLVLCLTPLSISSA 278
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 9-178 7.63e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 50.34  E-value: 7.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGA-SGSMALSIAMaIAIDiTPPHHLGRVMAKIMTGFTL 87
Cdd:cd17391    58 RLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVfSGYVPNATAL-IASQ-TPKEKSGWALGTLSTGVVA 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  88 ATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQPN---IIRMYILQALNQF 164
Cdd:cd17391   136 GTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNpslLISLFVTTFIIQL 215

                         170
                  ....*....|....
gi 1434114610 165 SAFLIIPTLSAYLM 178
Cdd:cd17391   216 ANQSIEPILTLYIR 229
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 10-150 7.84e-07

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 50.09  E-value: 7.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLAT 89
Cdd:PRK10091   61 FSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVAN 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1434114610  90 VLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPssnSVLDEPEKK-DASAYFLKQP 150
Cdd:PRK10091  141 LLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVP---DIRDEAKGGlREQFHFLRSP 199
PRK12307 PRK12307
MFS transporter;
2-170 7.90e-07

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 50.31  E-value: 7.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKI 81
Cdd:PRK12307   68 FGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  82 MTGFTLATVLGVPLVLTLSEQYGWQYCFlLIGLLAVVLYVYTYFKLPSSNSvLDEPEKKDASAYFLKQPNIIRMYILQAL 161
Cdd:PRK12307  148 VSGFGIGNIIAAYFMPSFAEAYGWRAAF-FVGLLPVLLVIYIRARAPESKE-WEEAKLSGKGKHSQSAWSVFSLSMKGLF 225

                         170
                  ....*....|.
gi 1434114610 162 N--QFSAFLII 170
Cdd:PRK12307  226 NraQFPLTLCV 236
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 3-130 1.87e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 49.17  E-value: 1.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   3 LGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSmALSIAMAIAIDITPP----HHLGRVM 78
Cdd:cd17388    58 LGALS----DRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGA-TGAVAAAYIADVTPPeqraRNFGLLG 132

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1434114610  79 AKIMTGFTLATVLGvplvlTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSS 130
Cdd:cd17388   133 AAFGLGFIAGPALG-----GLLGEISPRAPFLVAAGLNGLNFLLGLFVLPES 179
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 3-130 2.27e-06

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 48.93  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   3 LGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIM 82
Cdd:PRK03893   75 LGAMG----DRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLI 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1434114610  83 TGFTLATVLGVPLVLTLSEQYGWQYCFlLIGLLAVVLYVYTYFKLPSS 130
Cdd:PRK03893  151 SGFSIGAVVAAQVYSLVVPVWGWRALF-FIGILPIIFALWLRKNLPEA 197
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 4-128 5.16e-06

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 47.65  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   4 GALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSmALSIAMAIAIDITPPHHLGRVMAKIMT 83
Cdd:cd17389    85 GAAS----DVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKG-NVSLSTAIVADVTSPKKRSKGMALIGV 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1434114610  84 GFTLATVLG------VPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLP 128
Cdd:cd17389   160 AFSLGFIIGpmigayFASFTRSLGEVFFSMPALFALVLALADLLFIFFFLP 210
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 2-130 6.26e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 47.57  E-value: 6.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSL-KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIA-MAIAiDITPPHHLGR--V 77
Cdd:cd17315    48 AIGSLFGgPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVpLYIS-EIAPAKIRGAlgT 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1434114610  78 MAKIMT--GFTLATVLGVPLVLTLSEqyGWQYCFLLIGLLAVVLYVYTYFkLPSS 130
Cdd:cd17315   127 LNQLMItfGILLAYLLGLALSLSPPG--WWRLMFALAAVPALLQLLLMFF-LPES 178
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 2-153 7.94e-06

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 47.16  E-value: 7.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSLKfidRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIA---IDITPPHHLGRVM 78
Cdd:cd17471    51 WLGRLSDR---GGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAreyADRSSGRDATLFN 127

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1434114610  79 AKIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQPNII 153
Cdd:cd17471   128 SVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLL 202
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 12-129 1.46e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 46.39  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYN-RRTLLLSS--WGVFALSTLMCAWaQNFQQLFFTRALVGASGSMAL-SIAMAIAIDItPPHHLGRVMAKIMTGFTL 87
Cdd:cd17380    59 DRFGgKKVLLLAValWSLATLLTPLLAY-SSLPLLILSRILLGLGEGVHFpSMTSLFSRWV-PVSERSRAVSIVTAGSYL 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1434114610  88 ATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPS 129
Cdd:cd17380   137 GTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLPP 178
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
1-128 2.19e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 45.68  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:PRK11102   44 LFYGPMA----DSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSF 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLP 128
Cdd:PRK11102  120 VTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 2-128 2.51e-05

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 45.37  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSLKFIDRYNR-RTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:cd06180    48 LVGALLASFLRRRGRaRRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGL 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1434114610  81 IMTGFTLATVLG-----VPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLP 128
Cdd:cd06180   128 LFAGVGLGIALSgllvpAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPS 180
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 8-122 3.08e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.30  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   8 LKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTL 87
Cdd:cd17329   257 ARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGL 336

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1434114610  88 ATVL----GVPLVLTLSEQYGWQYCFLLIGLLAVVLYVY 122
Cdd:cd17329   337 GRAIgplvGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 1-125 3.94e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFI-DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMA 79
Cdd:cd17473   246 GAIGALLFGRLkRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG 325

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1434114610  80 KIMTGFTLATVLGvPLVLTLSEQY--GWQYCFLLIGLLAVVLYVYTYF 125
Cdd:cd17473   326 IVTSAFFLGQFLS-PLVLGPLVNLtgGLSGAFLILGVLALVLAIVLLL 372
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
12-141 5.58e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 44.50  E-value: 5.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRAL--VGASGsmALSIAMAIAIDITPPHHLGRVMAKIMTGFTLAT 89
Cdd:PRK11043   66 DRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVqaVGVCS--AAVIWQALVIDRYPAQKANRVFATIMPLVALSP 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1434114610  90 VLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKD 141
Cdd:PRK11043  144 ALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQSQDALT 195
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
3-129 6.39e-05

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 44.54  E-value: 6.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   3 LGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRAL-------VGASGSMAL--SIAMAIAIDITPphh 73
Cdd:PRK15402   68 LGPLS----DRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLqgiglcfIGAVGYAAIqeSFEEADAIKITA--- 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1434114610  74 lgrVMAKIMtgfTLATVLGvPLVLTLSEQYG-WQYCFLLIGLLAVVLYVYTYFKLPS 129
Cdd:PRK15402  141 ---LMANVA---LLAPLLG-PLVGAALIHVLpWRGMFVLFAALAALSFFGLWRAMPE 190
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-253 6.50e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.48  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMAlSIAMAIAIDITPPHHLGRVMAK 80
Cdd:COG2807    67 GLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG-NVLLPGLIKRWFPDRVGLMTGL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQPNIIRMYILQA 160
Cdd:COG2807   146 YTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFG 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 161 LNQFSAFLIIPTLSAYLMfnfaiEREY--------LPYFYLLGGVVSFITIHTLGRIADNKstdMTLFLGTTIYATGLFA 232
Cdd:COG2807   226 LQSLLYYAVVAWLPPILR-----DAGLsaatagllLSLFQLAGIPGSLLVPLLADRLGDRR---PLLLLLGLLGLAGLLG 297

                         250       260
                  ....*....|....*....|.
gi 1434114610 233 FSFNALPIWLTLVCFVAFMAG 253
Cdd:COG2807   298 LLLAPGSLPWLWAVLLGLGQG 318
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 4-130 9.62e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 43.71  E-value: 9.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   4 GALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMA---- 79
Cdd:cd17359    53 ALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSlnql 132

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1434114610  80 KIMTGFTLATV----LGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFkLPSS 130
Cdd:cd17359   133 MIVFGQLLAYIvnylIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLF-IPES 186
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 12-149 1.20e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 43.41  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLATVL 91
Cdd:PRK11551   75 DRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGAL 154

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1434114610  92 GVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYFLKQ 149
Cdd:PRK11551  155 ASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRA 212
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-91 1.34e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.04  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:COG2814   257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336

                          90
                  ....*....|.
gi 1434114610  81 IMTGFTLATVL 91
Cdd:COG2814   337 YNSAFFLGGPL 347
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-256 1.67e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHlGRVMAK 80
Cdd:COG0738    57 LLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  81 IMTGFTLATVLG---VPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF-KLPSSNSVLDEPEKKDASAYF-LKQPNIIRM 155
Cdd:COG0738   136 LHAFFSLGALLGpllGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRsKLPEIEEEEEEAAGSAASLKSlLKNPRLLLG 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 156 YILQALNQFSAFLIIPTLSAYLMFNFAIERE----YLPYFYLLGGVVSFITIHTLGRIADNKstdmtLFLGTTIYATGLF 231
Cdd:COG0738   216 GLAIFLYVGAEGAIGDWLPLYLKDVLGLSEAtaalGLSLFWGGMTIGRFLGGFLLKRFGPVR-----LLRLSALLAAVGL 290

                         250       260
                  ....*....|....*....|....*
gi 1434114610 232 AFSFNALPIWLTLVCFVAFMAGNAG 256
Cdd:COG0738   291 LLALLAPGPWLALIGLALVGLGLSL 315
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
2-255 1.97e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 42.99  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDItPPHHLGRVMAKI 81
Cdd:PRK09874   73 FWGGLA----DRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQV-PRNKSGWALGTL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  82 MTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKDASAYF--LKQPN-IIRMYIL 158
Cdd:PRK09874  148 STGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVSKKEMLHMREVVtsLKNPKlVLSLFVT 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 159 QALNQFSAFLIIPTLSAY---LMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATGLFAFSF 235
Cdd:PRK09874  228 TLIIQVATGSIAPILTLYvreLAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSF 307

                         250       260
                  ....*....|....*....|
gi 1434114610 236 NALPIWLTLVCFVAFMAGNA 255
Cdd:PRK09874  308 VQTPLQLGILRFLLGAADGA 327
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 16-125 2.18e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 42.61  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  16 RRTLLLS--SWGVFALSTLMCAWAqNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLATVLGV 93
Cdd:cd17318    86 KRVLGYSilITALLTLLTPLAARG-GYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAM 164

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1434114610  94 PLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF 125
Cdd:cd17318   165 PLSGFLCESLGWPSIFYIFGGLGLLWCLLWFF 196
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 7-125 3.87e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.82  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   7 SLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFT 86
Cdd:cd17490   251 GTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYA 330

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1434114610  87 LATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF 125
Cdd:cd17490   331 LGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 11-129 4.26e-04

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 41.71  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  11 IDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMA----KIMTGFT 86
Cdd:cd17435    60 IDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSlnelMIVIGIL 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1434114610  87 LATVLGvplVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPS 129
Cdd:cd17435   140 LAYISN---YAFANVSNGWKYMFGLVIPLAALQAIAMYFLPPS 179
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 1-125 5.73e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 41.38  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGsmaLSIAMAIAIDITP---PHHLGRV 77
Cdd:cd17352    52 LFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLG---LGLIYSPAIVIVGqyfEKKRGLA 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1434114610  78 MAKIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF 125
Cdd:cd17352   129 TGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLL 176
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 3-130 8.14e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 40.80  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   3 LGAL-----SLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRV 77
Cdd:cd17362    50 LGALlgslvAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLL 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1434114610  78 M----AKIMTGFTLATVLGVPLVLTLSeqyGWQYCFLLIGLLAVVLYVYTYFkLPSS 130
Cdd:cd17362   130 VslkeLFIVLGILLGYVSGYAFADVVG---GWRYMYGLAAPPALLLGIGMWF-LPPS 182
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 1-130 9.52e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 40.77  E-value: 9.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFI-DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMA 79
Cdd:TIGR00898 140 VLLGSFVFGYLsDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGT 219

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1434114610  80 KIMTGFTLATVLgVPLVLTLSEQygWQYCFLLIGLLAVVLYVYtYFKLPSS 130
Cdd:TIGR00898 220 LIQVFFSLGLVL-LPLVAYFIPD--WRWLQLAVSLPTFLFFLL-SWFVPES 266
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 2-123 1.29e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMAL-SIAMAIAIDITPPHHLGRVMAK 80
Cdd:cd17477   242 PLGWLA----DRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLyTLALALAGDRLPGDELVAANAA 317

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYT 123
Cdd:cd17477   318 LLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 10-155 1.50e-03

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 39.90  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRY------NRRTLLLSSWGVFALSTLMCAWAQNFQQLfftRALVGASGSMALSIAM------AIAIDITPPHHLGRV 77
Cdd:cd17485    53 LVDRYglprlgRRRSWLLPTQLGLALLLLALAFLPPTTNL---LAFLGLLFLLNLFSATqdiatdGLAVELLTPEERGLG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  78 MAKIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF-----KLPSSNSVLDEPEKKDASAYFLKQPNI 152
Cdd:cd17485   130 NAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFlreleLPQQPPASERGAALKASLRAFLRRPGT 209


                  ...
gi 1434114610 153 IRM 155
Cdd:cd17485   210 RWL 212
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 10-116 1.92e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 39.70  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  10 FIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFT-RALVGASGSMALSIAMAIAIDITPpHHLGRVMAKIMTGFTLA 88
Cdd:cd17314    61 IADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYAcFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLG 139

                          90       100
                  ....*....|....*....|....*...
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLA 116
Cdd:cd17314   140 LVLGSPLLRILWVFYGLALVYTILGILA 167
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 1-116 1.96e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.48  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWA---QNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRV 77
Cdd:cd17503   228 AILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDA 307

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1434114610  78 MAKIMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLA 116
Cdd:cd17503   308 TALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELLA 346
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 9-118 2.36e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   9 KFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLA 88
Cdd:cd17370   256 RLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIG 335

                          90       100       110
                  ....*....|....*....|....*....|
gi 1434114610  89 TVLGVPLVLTLSEQYGWQYCFLLIGLLAVV 118
Cdd:cd17370   336 WLLASLIAGYLWDLISPSAAFLFSAVLALI 365
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
12-125 2.53e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.48  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYNRRTLLLSSWGVFALSTLMCAWAQ-NFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMTGFTLATV 90
Cdd:COG2223   266 DRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGF 345

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1434114610  91 LGVPLVLTLSEQYG-WQYCFLLIGLLAVVLYVYTYF 125
Cdd:COG2223   346 LGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLL 381
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 4-125 3.06e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.10  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   4 GALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIMT 83
Cdd:cd17330   228 LLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQS 307

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1434114610  84 GFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYF 125
Cdd:cd17330   308 LQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 1-272 3.84e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 38.74  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRalVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:cd17331    49 LVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR--LPSVFMHAMQAAQMVVTDLTDPGERAAALGR 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPSSNSVLDEPEKKD-----------ASAYFLKQ 149
Cdd:cd17331   127 LGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKEsasppsvfnlkEILRLLRL 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610 150 PNIIRMYILQALNQFSAFLIIPTLSAYLMFNFAIEREYLPYFYLLGGVVSFITIHTLGRIADNKSTDMTLFLGTTIYATG 229
Cdd:cd17331   207 PGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAI 286

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1434114610 230 LFAFSFNALPIWLTLVCFVAFMAGNAGRNISLTTSSSRIPEPS 272
Cdd:cd17331   287 GYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPE 329
nepI PRK10213
purine ribonucleoside efflux pump NepI;
1-129 3.88e-03

purine ribonucleoside efflux pump NepI;


Pssm-ID: 182309 [Multi-domain]  Cd Length: 394  Bit Score: 38.75  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   1 MFLGALSLKFIDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAK 80
Cdd:PRK10213   69 MFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSV 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKLPS 129
Cdd:PRK10213  149 IFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPS 197
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 12-134 4.40e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 38.40  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610  12 DRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVGASGSMALSIAMAIAIDITPPHHLGRVMAKIM-----TGFT 86
Cdd:cd17476    58 DIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFgatapLGFA 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1434114610  87 LATVLGvPLVLTLSeQYGWQYcFLLIGLLAVVLYVYTYFKLPSSNSVL 134
Cdd:cd17476   138 LGGVFG-GLFAQLA-WWPWIF-WFLAILAAIVAVAAIFWTSPSFIAVL 182
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 2-127 6.83e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.01  E-value: 6.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434114610   2 FLGALSlkfiDRYNRRTLLLSSWGVFALSTLMCAWAQNFQQLFFTRALVG-ASGSMALSIAMAIAiDITPPHHLGRVMAK 80
Cdd:cd17391   259 RLGKLG----DRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGlATGGLLPAINSLLA-KITPKEVAGRIFGY 333

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1434114610  81 IMTGFTLATVLGVPLVLTLSEQYGWQYCFLLIGLLAVVLYVYTYFKL 127
Cdd:cd17391   334 NQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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