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Conserved domains on  [gi|1387289088|gb|AWI10170|]
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hypothetical protein CKA38_13695 [Ereboglobus luteus]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 11436314)

efflux RND transporter permease subunit similar to Bacillus subtilis swarming motility protein SwrC, which is required for self-resistance to surfactin, an antimicrobial lipopeptide surfactant produced by B. subtilis

PubMed:  19026770|10941792
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1015 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


:

Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1099.00  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    1 MILSDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNI 80
Cdd:COG0841      1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   81 QSTSQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNSDRYSRLELVELVEQL 160
Cdd:COG0841     81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  161 AIQRIQTVPGVGSVTVRGPR-FAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDF 239
Cdd:COG0841    161 IKDRLERVPGVGQVQIFGGReREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  240 ENLVLVTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAF 319
Cdd:COG0841    241 ENIVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  320 DNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINIltllalvlavglvvD 399
Cdd:COG0841    321 DQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNIltlfalvlaigivvD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  400 DAIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTL 479
Cdd:COG0841    401 DAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  480 TPMLCSRVLHPVKvvngVKKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAED 559
Cdd:COG0841    481 TPALCARLLKPHP----KGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEED 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  560 RGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTGDGG------RAWIYTTLVPWEDRKRKTQDVSADLRR 633
Cdd:COG0841    557 QGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGggsgsnSGTIFVTLKPWDERDRSADEIIARLRE 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  634 QFArEVTGGQAIVSAVRSFGGGRGaAGVTMVLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRAKA 713
Cdd:COG0841    637 KLA-KIPGARVFVFQPPAGGLGSG-APIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKA 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  714 ADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAESY 793
Cdd:COG0841    715 AALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSI 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  794 RHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADL-LTPGYTIAWDGETREYIESGNDTYMLFGLALLFTFLILAAQFES 872
Cdd:COG0841    795 NRYNGQRSVTVSANLAPGVSLGEALAAIEELAAELkLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFES 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  873 WIHPVTIFSGVVLAIAGGLMVLWSTRfwfatpMTDNLFSRFGLIMLIGLVAKNGILIVEFANQLQIEGKDAFTAAFQSAT 952
Cdd:COG0841    875 FIQPLIILLTVPLALIGALLGLLLTG------TPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGMSLREAILEAAR 948
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1387289088  953 IRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDRI 1015
Cdd:COG0841    949 LRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRL 1011
 
Name Accession Description Interval E-value
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1015 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1099.00  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    1 MILSDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNI 80
Cdd:COG0841      1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   81 QSTSQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNSDRYSRLELVELVEQL 160
Cdd:COG0841     81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  161 AIQRIQTVPGVGSVTVRGPR-FAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDF 239
Cdd:COG0841    161 IKDRLERVPGVGQVQIFGGReREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  240 ENLVLVTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAF 319
Cdd:COG0841    241 ENIVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  320 DNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINIltllalvlavglvvD 399
Cdd:COG0841    321 DQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNIltlfalvlaigivvD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  400 DAIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTL 479
Cdd:COG0841    401 DAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  480 TPMLCSRVLHPVKvvngVKKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAED 559
Cdd:COG0841    481 TPALCARLLKPHP----KGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEED 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  560 RGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTGDGG------RAWIYTTLVPWEDRKRKTQDVSADLRR 633
Cdd:COG0841    557 QGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGggsgsnSGTIFVTLKPWDERDRSADEIIARLRE 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  634 QFArEVTGGQAIVSAVRSFGGGRGaAGVTMVLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRAKA 713
Cdd:COG0841    637 KLA-KIPGARVFVFQPPAGGLGSG-APIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKA 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  714 ADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAESY 793
Cdd:COG0841    715 AALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSI 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  794 RHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADL-LTPGYTIAWDGETREYIESGNDTYMLFGLALLFTFLILAAQFES 872
Cdd:COG0841    795 NRYNGQRSVTVSANLAPGVSLGEALAAIEELAAELkLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFES 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  873 WIHPVTIFSGVVLAIAGGLMVLWSTRfwfatpMTDNLFSRFGLIMLIGLVAKNGILIVEFANQLQIEGKDAFTAAFQSAT 952
Cdd:COG0841    875 FIQPLIILLTVPLALIGALLGLLLTG------TPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGMSLREAILEAAR 948
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1387289088  953 IRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDRI 1015
Cdd:COG0841    949 LRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRL 1011
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1014 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 862.79  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    4 SDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQST 83
Cdd:NF033617     1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   84 SQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIIT-KADPDATPVITLSFNSDRYSRLELVELVEQLAI 162
Cdd:NF033617    81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYrKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  163 QRIQTVPGVGSVTVRG-PRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDFEN 241
Cdd:NF033617   161 PKLSQINGVGSVDVSGgQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  242 LVL-VTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAFD 320
Cdd:NF033617   241 LVIkYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  321 NSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVDD 400
Cdd:NF033617   321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  401 AIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTLT 480
Cdd:NF033617   401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  481 PMLCSRVL--HPvkvvngvkKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAE 558
Cdd:NF033617   481 PMMCSRLLkaNE--------KPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSE 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  559 DRGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTGDGG-----RAWIYTTLVPWEDRKRKTQDVSADLRR 633
Cdd:NF033617   553 DRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVGGnpgdnTGFGIINLKPWDERDVSAQEIIDRLRP 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  634 QFArEVTGGQAIVSAVRS-FGGGRGAAGVTMVLL-GSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRA 711
Cdd:NF033617   633 KLA-KVPGMDLFLFPLQDlPGGAGSSLPQYQVTLtPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRD 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  712 KAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAE 791
Cdd:NF033617   712 KAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPL 791
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  792 SYRHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADLLTPGYTIAWDGETREYIESGNDTYMLFGLALLFTFLILAAQFE 871
Cdd:NF033617   792 SLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYE 871
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  872 SWIHPVTIFSGVVLAIAGGLMVLWstrfWFATPMtdNLFSRFGLIMLIGLVAKNGILIVEFANQLQIE-GKDAFTAAFQS 950
Cdd:NF033617   872 SFVDPLTILSTVPLAGCGALLALA----LGGQSM--NIYAQIGLITLIGLVKKNGILMVEFANELQRHqGLSRREAIYQA 945
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387289088  951 ATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDR 1014
Cdd:NF033617   946 AALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
3-1013 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 821.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    3 LSDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQS 82
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   83 TSQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNSD--RYSRLELVELVEQL 160
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADTN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  161 AIQRIQTVPGVGSVTVRGPR-FAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDF 239
Cdd:pfam00873  161 IKPQLSRVPGVGDVQLFGGSeYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  240 ENLVLVTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAF 319
Cdd:pfam00873  241 EKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVVY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  320 DNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVD 399
Cdd:pfam00873  321 DTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  400 DAIVVLENIYRRMEH-GENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALT 478
Cdd:pfam00873  401 DAIVVVENIERVLEEnGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVALT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  479 LTPMLCSRVLHPVKvvngVKKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAE 558
Cdd:pfam00873  481 LTPALCATLLKPRR----EPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEE 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  559 DRGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTGDG--------GRAWIYTTLVPWEDRKRKTQDVSAD 630
Cdd:pfam00873  557 DEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAfsgdnngpNSGDAFISLKPWKERPGPEKSVQAL 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  631 LRRQFA--REVTGGQAIVSAVRSFGGGRGAAGVTM----VLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQL 704
Cdd:pfam00873  637 IERLRKalKQIPGANVFLFQPIQLRGLGTISGFRSdlqvKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQL 716
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  705 QLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSW 784
Cdd:pfam00873  717 QVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKI 796
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  785 TEDTVAESYRHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADL-LTPGYTIAWDGETREYIESGNDTYMLFGLALLFTF 863
Cdd:pfam00873  797 EWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVkLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVF 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  864 LILAAQFESWIHPVTIFSGVVLAIAGGLMVLWstrfWFATPMtdNLFSRFGLIMLIGLVAKNGILIVEFANQLQ-IEGKD 942
Cdd:pfam00873  877 LVLAALYESWSDPLSIMLTVPLALVGALLALW----LRGLPN--SVYAQVGLILLIGLAVKNAILMVEFANELReQEGKS 950
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387289088  943 AFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLD 1013
Cdd:pfam00873  951 LEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
8-1015 0e+00

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 667.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    8 IKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQSTSQEE 87
Cdd:TIGR00915    6 IDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSD 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   88 -SSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIIT--KADPDATPVITLSFNSDRYSRLELVELVEQLAIQR 164
Cdd:TIGR00915   86 gSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRveKASSNFLMVIGLVSDDGSMTKEDLSDYAASNMVDP 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  165 IQTVPGVGSVTVRGPRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRI------ESSAREFPLRMEGRMQEVVD 238
Cdd:TIGR00915  166 LSRLEGVGDVQLFGSQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpavPGQQLNATIIAQTRLQTPEQ 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  239 FENLVLVTRGD-YQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQV 317
Cdd:TIGR00915  246 FENILLKVNTDgSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQGMKYVY 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  318 AFDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLV 397
Cdd:TIGR00915  326 PYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLL 405
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  398 VDDAIVVLENIYRRM-EHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVA 476
Cdd:TIGR00915  406 VDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVA 485
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  477 LTLTPMLCSRVLHPVkvvngvkKHGWLYDKTEPFFVWFNKC-------YERLLRVATNNKALVLLAALAFSCAGFWLYTK 549
Cdd:TIGR00915  486 LILTPALCATMLKPI-------EKGEHHEKKGGFFGWFNRMfdssthgYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  550 LQRELTPAEDRGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVP--EIDRTYHRTGDG--GR----AWIYTTLVPWEDRK 621
Cdd:TIGR00915  559 LPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEkaNVESVFTVNGFSfaGRgqnmGMAFIRLKDWEERT 638
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  622 RKTQDVSADLRRQFAREVTGGQAIV-----SAVRSFGggrGAAGVTMVL---LGSEFNELQRLGALFVKDMLESGHFVQP 693
Cdd:TIGR00915  639 GKENSVFAIAGRATGHFMQIKDAMViafvpPAILELG---NATGFDFFLqdrAGLGHEALLQARNQLLGLAAQNPALTRV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  694 RVDPSPTKPQLQLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEG 773
Cdd:TIGR00915  716 RPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASG 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  774 NLVQLSNLVSWTEDTVAESYRHFDRMRSVVVSSQLSPGFTIGDAVDYLnARGADLLTPGYTIAWDGETREYIESGNDTYM 853
Cdd:TIGR00915  796 EMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAM-EAIAQKLPPGFGFSWTGMSYEERLSGSQAPA 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  854 LFGLALLFTFLILAAQFESWIHPVTIFSGVVLAIAGGLMVLWSTRFwfatpmTDNLFSRFGLIMLIGLVAKNGILIVEFA 933
Cdd:TIGR00915  875 LYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGL------SNDVYFQVGLLTTIGLSAKNAILIVEFA 948
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  934 NQLQIEGKDAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLD 1013
Cdd:TIGR00915  949 KELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVR 1028

                   ..
gi 1387289088 1014 RI 1015
Cdd:TIGR00915 1029 RL 1030
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
1-1014 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 612.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    1 MILSDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNI 80
Cdd:PRK09579     1 MAFTDPFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   81 QSTSQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNSDRYSRLELVELVEQL 160
Cdd:PRK09579    81 TSVSRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADASALMYISFYSEEMSNPQITDYLSRV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  161 AIQRIQTVPGVGSVTVRGPR-FAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDF 239
Cdd:PRK09579   161 IQPKLATLPGMAEAEILGNQvFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  240 ENLVLVTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAF 319
Cdd:PRK09579   241 AAIPVKTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIAY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  320 DNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVD 399
Cdd:PRK09579   321 DATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  400 DAIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTL 479
Cdd:PRK09579   401 DAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVALTL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  480 TPMLCSRVLHPVKVVNGvkkhgwLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAED 559
Cdd:PRK09579   481 SPMMCALLLRHEENPSG------LAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFTQSELAPEED 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  560 RGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTG-DGGRAWIYTTLV-PWEDRKRKTQDVSADLRRQFaR 637
Cdd:PRK09579   555 QGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGfNGVQSGIGGFLLkPWNERERTQMELLPLVQAKL-E 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  638 EVTGGQAIVSAVRSF-GGGRGAAGVTMVLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRAKAADM 716
Cdd:PRK09579   634 EIPGLQIFGFNLPSLpGTGEGLPFQFVINTANDYESLLQVAQRVKQRAQESGKFAFLDIDLAFDKPEVVVDIDRAKAAQM 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  717 RVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAESYRHF 796
Cdd:PRK09579   714 GVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQF 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  797 DRMRSVVVSSqlSPGFTIGDAVDYLNARGADLLTPGYTIAWDGETREYIESGNDTYMLFGLALLFTFLILAAQFESWIHP 876
Cdd:PRK09579   794 QQLNSAIISG--FPIVSMGEAIETVQQIAREEAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDP 871
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  877 VTIFSGVVLAIAGGLMVL---WSTRfwfatpmtdNLFSRFGLIMLIGLVAKNGILIVEFANQLQIE-GKDAFTAAFQSAT 952
Cdd:PRK09579   872 LVILVTVPLSICGALIPLflgVSSM---------NIYTQVGLVTLIGLISKHGILIVEFANQLRHEqGLSRREAIEEAAA 942
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387289088  953 IRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDR 1014
Cdd:PRK09579   943 IRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLAK 1004
 
Name Accession Description Interval E-value
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1015 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1099.00  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    1 MILSDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNI 80
Cdd:COG0841      1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   81 QSTSQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNSDRYSRLELVELVEQL 160
Cdd:COG0841     81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  161 AIQRIQTVPGVGSVTVRGPR-FAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDF 239
Cdd:COG0841    161 IKDRLERVPGVGQVQIFGGReREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  240 ENLVLVTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAF 319
Cdd:COG0841    241 ENIVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  320 DNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINIltllalvlavglvvD 399
Cdd:COG0841    321 DQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNIltlfalvlaigivvD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  400 DAIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTL 479
Cdd:COG0841    401 DAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  480 TPMLCSRVLHPVKvvngVKKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAED 559
Cdd:COG0841    481 TPALCARLLKPHP----KGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEED 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  560 RGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTGDGG------RAWIYTTLVPWEDRKRKTQDVSADLRR 633
Cdd:COG0841    557 QGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGggsgsnSGTIFVTLKPWDERDRSADEIIARLRE 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  634 QFArEVTGGQAIVSAVRSFGGGRGaAGVTMVLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRAKA 713
Cdd:COG0841    637 KLA-KIPGARVFVFQPPAGGLGSG-APIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKA 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  714 ADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAESY 793
Cdd:COG0841    715 AALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSI 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  794 RHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADL-LTPGYTIAWDGETREYIESGNDTYMLFGLALLFTFLILAAQFES 872
Cdd:COG0841    795 NRYNGQRSVTVSANLAPGVSLGEALAAIEELAAELkLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFES 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  873 WIHPVTIFSGVVLAIAGGLMVLWSTRfwfatpMTDNLFSRFGLIMLIGLVAKNGILIVEFANQLQIEGKDAFTAAFQSAT 952
Cdd:COG0841    875 FIQPLIILLTVPLALIGALLGLLLTG------TPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGMSLREAILEAAR 948
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1387289088  953 IRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDRI 1015
Cdd:COG0841    949 LRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRL 1011
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1014 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 862.79  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    4 SDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQST 83
Cdd:NF033617     1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   84 SQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIIT-KADPDATPVITLSFNSDRYSRLELVELVEQLAI 162
Cdd:NF033617    81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYrKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  163 QRIQTVPGVGSVTVRG-PRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDFEN 241
Cdd:NF033617   161 PKLSQINGVGSVDVSGgQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  242 LVL-VTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAFD 320
Cdd:NF033617   241 LVIkYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  321 NSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVDD 400
Cdd:NF033617   321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  401 AIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTLT 480
Cdd:NF033617   401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  481 PMLCSRVL--HPvkvvngvkKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAE 558
Cdd:NF033617   481 PMMCSRLLkaNE--------KPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSE 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  559 DRGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTGDGG-----RAWIYTTLVPWEDRKRKTQDVSADLRR 633
Cdd:NF033617   553 DRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVGGnpgdnTGFGIINLKPWDERDVSAQEIIDRLRP 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  634 QFArEVTGGQAIVSAVRS-FGGGRGAAGVTMVLL-GSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRA 711
Cdd:NF033617   633 KLA-KVPGMDLFLFPLQDlPGGAGSSLPQYQVTLtPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRD 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  712 KAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAE 791
Cdd:NF033617   712 KAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPL 791
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  792 SYRHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADLLTPGYTIAWDGETREYIESGNDTYMLFGLALLFTFLILAAQFE 871
Cdd:NF033617   792 SLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYE 871
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  872 SWIHPVTIFSGVVLAIAGGLMVLWstrfWFATPMtdNLFSRFGLIMLIGLVAKNGILIVEFANQLQIE-GKDAFTAAFQS 950
Cdd:NF033617   872 SFVDPLTILSTVPLAGCGALLALA----LGGQSM--NIYAQIGLITLIGLVKKNGILMVEFANELQRHqGLSRREAIYQA 945
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387289088  951 ATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDR 1014
Cdd:NF033617   946 AALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
3-1013 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 821.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    3 LSDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQS 82
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   83 TSQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNSD--RYSRLELVELVEQL 160
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADTN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  161 AIQRIQTVPGVGSVTVRGPR-FAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDF 239
Cdd:pfam00873  161 IKPQLSRVPGVGDVQLFGGSeYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  240 ENLVLVTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAF 319
Cdd:pfam00873  241 EKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVVY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  320 DNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVD 399
Cdd:pfam00873  321 DTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  400 DAIVVLENIYRRMEH-GENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALT 478
Cdd:pfam00873  401 DAIVVVENIERVLEEnGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVALT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  479 LTPMLCSRVLHPVKvvngVKKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAE 558
Cdd:pfam00873  481 LTPALCATLLKPRR----EPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEE 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  559 DRGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTGDG--------GRAWIYTTLVPWEDRKRKTQDVSAD 630
Cdd:pfam00873  557 DEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAfsgdnngpNSGDAFISLKPWKERPGPEKSVQAL 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  631 LRRQFA--REVTGGQAIVSAVRSFGGGRGAAGVTM----VLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQL 704
Cdd:pfam00873  637 IERLRKalKQIPGANVFLFQPIQLRGLGTISGFRSdlqvKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQL 716
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  705 QLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSW 784
Cdd:pfam00873  717 QVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKI 796
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  785 TEDTVAESYRHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADL-LTPGYTIAWDGETREYIESGNDTYMLFGLALLFTF 863
Cdd:pfam00873  797 EWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVkLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVF 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  864 LILAAQFESWIHPVTIFSGVVLAIAGGLMVLWstrfWFATPMtdNLFSRFGLIMLIGLVAKNGILIVEFANQLQ-IEGKD 942
Cdd:pfam00873  877 LVLAALYESWSDPLSIMLTVPLALVGALLALW----LRGLPN--SVYAQVGLILLIGLAVKNAILMVEFANELReQEGKS 950
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387289088  943 AFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLD 1013
Cdd:pfam00873  951 LEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
8-1015 0e+00

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 667.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    8 IKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQSTSQEE 87
Cdd:TIGR00915    6 IDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSD 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   88 -SSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIIT--KADPDATPVITLSFNSDRYSRLELVELVEQLAIQR 164
Cdd:TIGR00915   86 gSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRveKASSNFLMVIGLVSDDGSMTKEDLSDYAASNMVDP 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  165 IQTVPGVGSVTVRGPRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRI------ESSAREFPLRMEGRMQEVVD 238
Cdd:TIGR00915  166 LSRLEGVGDVQLFGSQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpavPGQQLNATIIAQTRLQTPEQ 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  239 FENLVLVTRGD-YQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQV 317
Cdd:TIGR00915  246 FENILLKVNTDgSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQGMKYVY 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  318 AFDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLV 397
Cdd:TIGR00915  326 PYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLL 405
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  398 VDDAIVVLENIYRRM-EHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVA 476
Cdd:TIGR00915  406 VDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVA 485
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  477 LTLTPMLCSRVLHPVkvvngvkKHGWLYDKTEPFFVWFNKC-------YERLLRVATNNKALVLLAALAFSCAGFWLYTK 549
Cdd:TIGR00915  486 LILTPALCATMLKPI-------EKGEHHEKKGGFFGWFNRMfdssthgYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  550 LQRELTPAEDRGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVP--EIDRTYHRTGDG--GR----AWIYTTLVPWEDRK 621
Cdd:TIGR00915  559 LPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEkaNVESVFTVNGFSfaGRgqnmGMAFIRLKDWEERT 638
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  622 RKTQDVSADLRRQFAREVTGGQAIV-----SAVRSFGggrGAAGVTMVL---LGSEFNELQRLGALFVKDMLESGHFVQP 693
Cdd:TIGR00915  639 GKENSVFAIAGRATGHFMQIKDAMViafvpPAILELG---NATGFDFFLqdrAGLGHEALLQARNQLLGLAAQNPALTRV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  694 RVDPSPTKPQLQLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEG 773
Cdd:TIGR00915  716 RPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASG 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  774 NLVQLSNLVSWTEDTVAESYRHFDRMRSVVVSSQLSPGFTIGDAVDYLnARGADLLTPGYTIAWDGETREYIESGNDTYM 853
Cdd:TIGR00915  796 EMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAM-EAIAQKLPPGFGFSWTGMSYEERLSGSQAPA 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  854 LFGLALLFTFLILAAQFESWIHPVTIFSGVVLAIAGGLMVLWSTRFwfatpmTDNLFSRFGLIMLIGLVAKNGILIVEFA 933
Cdd:TIGR00915  875 LYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGL------SNDVYFQVGLLTTIGLSAKNAILIVEFA 948
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  934 NQLQIEGKDAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLD 1013
Cdd:TIGR00915  949 KELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVR 1028

                   ..
gi 1387289088 1014 RI 1015
Cdd:TIGR00915 1029 RL 1030
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
1-1014 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 612.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    1 MILSDTSIKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNI 80
Cdd:PRK09579     1 MAFTDPFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   81 QSTSQEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNSDRYSRLELVELVEQL 160
Cdd:PRK09579    81 TSVSRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADASALMYISFYSEEMSNPQITDYLSRV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  161 AIQRIQTVPGVGSVTVRGPR-FAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDF 239
Cdd:PRK09579   161 IQPKLATLPGMAEAEILGNQvFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  240 ENLVLVTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAF 319
Cdd:PRK09579   241 AAIPVKTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIAY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  320 DNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVD 399
Cdd:PRK09579   321 DATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  400 DAIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTL 479
Cdd:PRK09579   401 DAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVALTL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  480 TPMLCSRVLHPVKVVNGvkkhgwLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAED 559
Cdd:PRK09579   481 SPMMCALLLRHEENPSG------LAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFTQSELAPEED 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  560 RGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTG-DGGRAWIYTTLV-PWEDRKRKTQDVSADLRRQFaR 637
Cdd:PRK09579   555 QGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGfNGVQSGIGGFLLkPWNERERTQMELLPLVQAKL-E 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  638 EVTGGQAIVSAVRSF-GGGRGAAGVTMVLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRAKAADM 716
Cdd:PRK09579   634 EIPGLQIFGFNLPSLpGTGEGLPFQFVINTANDYESLLQVAQRVKQRAQESGKFAFLDIDLAFDKPEVVVDIDRAKAAQM 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  717 RVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAESYRHF 796
Cdd:PRK09579   714 GVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQF 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  797 DRMRSVVVSSqlSPGFTIGDAVDYLNARGADLLTPGYTIAWDGETREYIESGNDTYMLFGLALLFTFLILAAQFESWIHP 876
Cdd:PRK09579   794 QQLNSAIISG--FPIVSMGEAIETVQQIAREEAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDP 871
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  877 VTIFSGVVLAIAGGLMVL---WSTRfwfatpmtdNLFSRFGLIMLIGLVAKNGILIVEFANQLQIE-GKDAFTAAFQSAT 952
Cdd:PRK09579   872 LVILVTVPLSICGALIPLflgVSSM---------NIYTQVGLVTLIGLISKHGILIVEFANQLRHEqGLSRREAIEEAAA 942
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387289088  953 IRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDR 1014
Cdd:PRK09579   943 IRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLAK 1004
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
8-1015 2.11e-170

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 527.50  E-value: 2.11e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    8 IKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQSTSQEE 87
Cdd:PRK09577     6 IDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAG 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   88 SSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDI--DEPIITKADPDATPVITLSFNSDRYSRLELVELVEQLAIQRI 165
Cdd:PRK09577    86 QASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVrrDGIQVEKAADNIQLIVSLTSDDGRLTGVELGEYASANVLQAL 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  166 QTVPGVGSVTVRGPRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRI------ESSAREFPLRMEGRMQEVVDF 239
Cdd:PRK09577   166 RRVEGVGKVQFWGAEYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIgrsavpDSAPIAATVFADAPLKTPEDF 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  240 ENLVLVTRGD-YQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVA 318
Cdd:PRK09577   246 GAIALRARADgSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPGVKYQIP 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  319 FDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVV 398
Cdd:PRK09577   326 YETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGILV 405
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  399 DDAIVVLENIYRRM-EHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVAL 477
Cdd:PRK09577   406 DDAIVVVENVERLMvEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGFSAFLAL 485
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  478 TLTPMLCSRVLHPVKvvngvkkhGWLYDKtEPFFVWFNKCYERLL-----RVAT--NNKALVLLAALAFSCAGFWLYTKL 550
Cdd:PRK09577   486 SLTPALCATLLKPVD--------GDHHEK-RGFFGWFNRFVARSTqryatRVGAilKRPLRWLVVYGALTAAAALLFTRL 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  551 QRELTPAEDRGVFTARLISPVGST-AEYLRLYSyDMEQMVLKVPEIDRTY-------HRTGDGGrAWIYTTLVPWEDRKR 622
Cdd:PRK09577   557 PTAFLPDEDQGNFMVMVIRPQGTPlAETMQSVR-EVESYLRRHEPVAYTFalggfnlYGEGPNG-GMIFVTLKDWKERKA 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  623 KTQDVSADLRRQFAREVTGGQAIVSAVRSfgggrgaagVTMVLLGSE--FN-ELQRLGAL----FV--KDMLESGHFVQP 693
Cdd:PRK09577   635 ARDHVQAIVARINERFAGTPNTTVFAMNS---------PALPDLGSTsgFDfRLQDRGGLgyaaFVaaREQLLAEGAKDP 705
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  694 RVDP-----SPTKPQLQLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYV 768
Cdd:PRK09577   706 ALTDlmfagTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRV 785
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  769 RSTEGNLVQLSNLVSWTEDTVAESYRHFDRMRSVVVSSQLSPGFTIGDAVDYLNaRGADLLTPGYTIAWDGETREYIESG 848
Cdd:PRK09577   786 RNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIE-RIAATLPAGIGYAWSGQSFEERLSG 864
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  849 NDTYMLFGLALLFTFLILAAQFESWIHPVTIFSGVVLAIAGGLMVLwSTRfwfatPMTDNLFSRFGLIMLIGLVAKNGIL 928
Cdd:PRK09577   865 AQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGV-TLR-----GMPNDIYFKVGLIATIGLSAKNAIL 938
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  929 IVEFANQLQIEGKDAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVL 1008
Cdd:PRK09577   939 IVEVAKDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLF 1018

                   ....*..
gi 1387289088 1009 YILLDRI 1015
Cdd:PRK09577  1019 FVVVGRL 1025
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
8-1015 4.98e-165

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 513.12  E-value: 4.98e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    8 IKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQSTSQEE 87
Cdd:PRK10614     8 IYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLG 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   88 SSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDI-DEPIITKADPDATPVITLSFNSDRYSRLELVELVE-QLAiQRI 165
Cdd:PRK10614    88 STRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSDTYSQGQLYDFAStQLA-QTI 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  166 QTVPGVGSVTVRGPRF-AMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDFENLVL 244
Cdd:PRK10614   167 SQIDGVGDVDVGGSSLpAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLII 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  245 VTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAFDNSTF 324
Cdd:PRK10614   247 HYNNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIAQDRSPT 326
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  325 VERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVDDAIVV 404
Cdd:PRK10614   327 IRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVV 406
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  405 LENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTLTPMLC 484
Cdd:PRK10614   407 LENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLTLTPMMC 486
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  485 SRVLHPVKVVNGVKKHGWlydktEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAEDRGVFT 564
Cdd:PRK10614   487 AWLLKSSKPREQKRLRGF-----GRMLVALQQGYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPEQDTGRLM 561
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  565 ARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTGdGGRA---WIYTTLVPWEDRKRKTQDVSADLRRQFAREvTG 641
Cdd:PRK10614   562 GFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTG-GSRVnsgMMFITLKPLSERSETAQQVIDRLRVKLAKE-PG 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  642 GQAIVSAVRSF-GGGRGA-AGVTMVLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRAKAADMRVK 719
Cdd:PRK10614   640 ANLFLMAVQDIrVGGRQSnASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGID 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  720 VSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAESYRHFDRM 799
Cdd:PRK10614   720 VQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLS 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  800 RSVVVSSQLSPGFTIGDAVDYLNARGADLLTPGyTI--AWDGETREYIESGNDTYMLFGLALLFTFLILAAQFESWIHPV 877
Cdd:PRK10614   800 AASTISFNLPTGKSLSDASAAIERAMTQLGVPS-TVrgSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHPL 878
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  878 TIFSGVVLAIAGGLMVLWstrfWFATPMTdnLFSRFGLIMLIGLVAKNGILIVEFANQLQIEGK-DAFTAAFQSATIRFR 956
Cdd:PRK10614   879 TILSTLPSAGVGALLALE----LFNAPFS--LIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNlTAQEAIFQACLLRFR 952
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387289088  957 PILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDRI 1015
Cdd:PRK10614   953 PIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL 1011
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
7-1014 1.31e-163

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 509.57  E-value: 1.31e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    7 SIKRPVVSLVASIFVVLLGVLSFMSLPVREYP-MTDTAVIsVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQSTSQ 85
Cdd:COG3696      9 SLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPdITNVQVQ-VITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSISR 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   86 EESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIdEPIITkadPDATPV-----ITLSFNSDRYSRLELVELVEQL 160
Cdd:COG3696     88 FGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGV-TPELG---PISTGLgeiyqYTLESDPGKYSLMELRTLQDWV 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  161 AIQRIQTVPGVGSVTVRGprFAMRMW---IDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVV 237
Cdd:COG3696    164 IRPQLRSVPGVAEVNSFG--GFVKQYqvlVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSLE 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  238 DFENLVLVTRGDYQVKFSDIGRVELGPE--------DYRSETyfkghltVSVAVVRQPNANLLDVVNGVKAVIPAVRTDL 309
Cdd:COG3696    242 DIENIVVKTRNGTPVLLRDVAEVRIGPAprrgaatlNGEGEV-------VGGIVLMLKGENALEVIEAVKAKLAELKPSL 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  310 PPGVNVQVAFDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLA 389
Cdd:COG3696    315 PEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGG 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  390 LVLAVGLVVDDAIVVLENIYRRMEH------GENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGI 463
Cdd:COG3696    395 LAIDFGIIVDGAVVMVENILRRLEEnraagtPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  464 TLAVAVLVSAFVALTLTPMLCSRVLhpvkvvNGVKKHGwlydktEPFFV-WFNKCYERLLRVATNNKALVLLAALAFSCA 542
Cdd:COG3696    475 TVIFALLGALLLSLTLVPVLASLLL------RGKVPEK------ENPLVrWLKRLYRPLLRWALRHPKLVLAVALVLLVL 542
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  543 GFWLYTKLQRELTPAEDRGVFTARLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTG---DGGRAW------IYTT 613
Cdd:COG3696    543 ALALFPRLGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGraeDATDPMgvnmseTFVI 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  614 LVPWED-RKRKTQD-VSADLRRQFARevtggqaIVSAVRSFG------------GGRGAAGVTmvLLGSEFNELQRLGAL 679
Cdd:COG3696    623 LKPRSEwRSGRTKEeLIAEMREALEQ-------IPGVNFNFSqpiqmrvdellsGVRADVAVK--IFGDDLDVLRRLAEQ 693
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  680 fVKDMLESghfVQ----PRVDPSPTKPQLQLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDA 755
Cdd:COG3696    694 -IEAVLKT---VPgaadVQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEE 769
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  756 KRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAESYRHFDRMRSVVVssqlspgftigdavdYLNARGADL------- 828
Cdd:COG3696    770 LRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVV---------------QANVRGRDLgsfvaea 834
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  829 ---------LTPGYTIAWDGETrEYIESGNDTYMLFG-LALLFTFLILAAQFESWIHPVTIFSGVVLAIAGGLMVLWSTR 898
Cdd:COG3696    835 qakvaeqvkLPPGYYIEWGGQF-ENLQRATARLAIVVpLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRG 913
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  899 FWFATPmtdnlfSRFGLIMLIGLVAKNGILIVEFANQLQIEGKDAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGA 978
Cdd:COG3696    914 MPLSVS------AGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGP 987
                         1050      1060      1070
                   ....*....|....*....|....*....|....*.
gi 1387289088  979 GAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDR 1014
Cdd:COG3696    988 GSEVQRPLATVVIGGLITSTLLTLLVLPALYLLFGR 1023
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
8-1014 2.94e-152

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 479.71  E-value: 2.94e-152
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    8 IKRPVVSLVASIFVVLLGVLSFMSLPVREYPmtDTAVISVR--TSYRGASAEVVETKITEPIEKELASIDGIRNIQS-TS 84
Cdd:PRK10555     6 IDRPIFAWVLAILLCLTGTLAIFSLPVEQYP--DLAPPNVRitANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSqSS 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   85 QEESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNS-----DRYSRLELVELVEQ 159
Cdd:PRK10555    84 GTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVStdgsmDKQDIADYVASNIQ 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  160 LAIQRIQtvpGVGSVTVRGPRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGR------IESSAREFPLRMEGRM 233
Cdd:PRK10555   164 DPLSRVN---GVGDIDAYGSQYSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQlggtpsVDKQALNATINAQSLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  234 QEVVDFENLVL-VTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPG 312
Cdd:PRK10555   241 QTPEQFRDITLrVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPHG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  313 VNVQVAFDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVL 392
Cdd:PRK10555   321 LEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  393 AVGLVVDDAIVVLENIYRRM-EHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLV 471
Cdd:PRK10555   401 AIGLLVDDAIVVVENVERIMsEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  472 SAFVALTLTPMLCSRVLHPVKVVNGVKKHGwlydktepFFVWFNKCYER-LLRVATN-----NKALVLLAALAFSCAGF- 544
Cdd:PRK10555   481 SVLVAMILTPALCATLLKPLKKGEHHGQKG--------FFGWFNRMFNRnAERYEKGvakilHRSLRWILIYVLLLGGMv 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  545 WLYTKLQRELTPAEDRGVFTARLISPVGSTaeylrlysydmEQMVLKVPEIDRTYHRT---------------GDGGR-- 607
Cdd:PRK10555   553 FLFLRLPTSFLPLEDRGMFTTSVQLPSGST-----------QQQTLKVVEKVEKYYFThekdnvmsvfatvgsGPGGNgq 621
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  608 --AWIYTTLVPWEDRKRKTQDVSADLRR--QFAREVTGGQAIVSAVRSFGGGRGAAGVTMvllgsefnELQRLGALfvkd 683
Cdd:PRK10555   622 nvARMFIRLKDWDERDSKTGTSFAIIERatKAFNKIKEARVIASSPPAISGLGSSAGFDM--------ELQDHAGA---- 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  684 mlesGH--FVQPR--------VDPSPTK---------PQLQLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQ 744
Cdd:PRK10555   690 ----GHdaLMAARnqllalaaKNPELTRvrhnglddsPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGR 765
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  745 QYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVSWTEDTVAESYRHFDRMRSVVVSSQLSPGFTIGDAVDYLNAR 824
Cdd:PRK10555   766 VKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESL 845
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  825 GADLLTpGYTIAWDGETREYIESGNDTYMLFGLALLFTFLILAAQFESWIHPVTIFSGVVLAIAGGLMVLWstrfwfATP 904
Cdd:PRK10555   846 VKQLPN-GFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATW------MRG 918
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  905 MTDNLFSRFGLIMLIGLVAKNGILIVEFANQLQIEGKDAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRN 984
Cdd:PRK10555   919 LENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQH 998
                         1050      1060      1070
                   ....*....|....*....|....*....|
gi 1387289088  985 PMGIVVVGGLTLSTVITLFVIPVLYILLDR 1014
Cdd:PRK10555   999 AVGTGVMGGMISATILAIFFVPLFFVLVRR 1028
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
8-1015 1.49e-151

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 478.07  E-value: 1.49e-151
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    8 IKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQSTSQEE 87
Cdd:PRK10503    17 ILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGG 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   88 SSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDI-DEPIITKADPDATPVITLSFNSDRYSRLELVELVEQLAIQRIQ 166
Cdd:PRK10503    97 ASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLpNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKIS 176
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  167 TVPGVGSVTVRG-PRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGRMQEVVDFENLVLV 245
Cdd:PRK10503   177 QVSGVGLVTLSGgQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQLIIA 256
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  246 TRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVNVQVAFDNSTFV 325
Cdd:PRK10503   257 YQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTTNI 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  326 ERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVDDAIVVL 405
Cdd:PRK10503   337 RASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVI 416
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  406 ENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSAFVALTLTPMLCS 485
Cdd:PRK10503   417 ENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCA 496
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  486 RVLHPvkvvNGVKKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCAGFWLYTKLQRELTPAEDRGVFTA 565
Cdd:PRK10503   497 RMLSQ----ESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKGFFPVQDNGIIQG 572
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  566 RLISPVGSTAEYLRLYSYDMEQMVLKVPEIDRTYHRTG-DG-------GRAWIytTLVPWEDRKRKTQDVSADLRRQFAR 637
Cdd:PRK10503   573 TLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGvDGtnpslnsARLQI--NLKPLDERDDRVQKVIARLQTAVAK 650
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  638 eVTGGQAIVSAVRSfgggrgaagvtmVLLGSEFNELQRLGALFVKDMLESGHFVQPRVDPSPTKPQLQ------------ 705
Cdd:PRK10503   651 -VPGVDLYLQPTQD------------LTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSdvssdwqdkglv 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  706 --LRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARLYVRSTEGNLVQLSNLVS 783
Cdd:PRK10503   718 ayVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAT 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  784 WTEDTVAESYRHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADLLTPG-YTIAWDGETREYIESGNDTYMLFGLALLFT 862
Cdd:PRK10503   798 IEQRFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPAdITTQFQGSTLAFQSALGSTVWLIVAAVVAM 877
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  863 FLILAAQFESWIHPVTIFSGVVLAIAGGLMVLWstrfwfATPMTDNLFSRFGLIMLIGLVAKNGILIVEFANQLQIE-GK 941
Cdd:PRK10503   878 YIVLGVLYESFIHPITILSTLPTAGVGALLALM------IAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREqGM 951
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387289088  942 DAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLFVIPVLYILLDRI 1015
Cdd:PRK10503   952 SPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRL 1025
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
8-1014 3.50e-148

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 469.38  E-value: 3.50e-148
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    8 IKRPVVSLVASIFVVLLGVLSFMSLPVREYPMTDTAVISVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQSTSQEE 87
Cdd:PRK15127     6 IDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDST 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   88 SS-RITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDEPIITKADPDATPVITLSFNSDRYS--RLELVELVEQLAIQR 164
Cdd:PRK15127    86 GTvQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTmtQEDISDYVAANMKDP 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  165 IQTVPGVGSVTVRGPRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSArefPLR---------MEGRMQE 235
Cdd:PRK15127   166 ISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGTP---PVKgqqlnasiiAQTRLTS 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  236 VVDFENLVLVTRGD-YQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPGVN 314
Cdd:PRK15127   243 TEEFGKILLKVNQDgSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLK 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  315 VQVAFDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAV 394
Cdd:PRK15127   323 IVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAI 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  395 GLVVDDAIVVLENIYRRM-EHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFGITLAVAVLVSA 473
Cdd:PRK15127   403 GLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSV 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  474 FVALTLTPMLCSRVLHPVKvvngVKKHGwlyDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAF-------SCAGFWL 546
Cdd:PRK15127   483 LVALILTPALCATMLKPIA----KGDHG---EGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTGRYlvlyliiVVGMAYL 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  547 YTKLQRELTPAEDRGVFTARLISPVGSTAE-------YLRLYSYDMEQMVLKVPEIDRTYHRTGDGGRAWI-YTTLVPWE 618
Cdd:PRK15127   556 FVRLPSSFLPDEDQGVFLTMVQLPAGATQErtqkvlnEVTDYYLTKEKNNVESVFAVNGFGFAGRGQNTGIaFVSLKDWA 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  619 DRKRKTQDVSADLRRQFAREVTGGQAIV-----SAVRSFGGGRG-------AAGVTMVLLGSEFNELQRLGALFvKDMLe 686
Cdd:PRK15127   636 DRPGEENKVEAITMRATRAFSQIKDAMVfafnlPAIVELGTATGfdfelidQAGLGHEKLTQARNQLLGEAAKH-PDML- 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  687 sghfVQPRVDPSPTKPQLQLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKRATPSDLARL 766
Cdd:PRK15127   714 ----VGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDW 789
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  767 YVRSTEGNLVQLSNLVSWTEDTVAESYRHFDRMRSVVVSSQLSPGFTIGDAVDYLNARGADLLTpGYTIAWDGETREYIE 846
Cdd:PRK15127   790 YVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELASKLPT-GVGYDWTGMSYQERL 868
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  847 SGNDTYMLFGLALLFTFLILAAQFESWIHPVTIFSGVVLAIAGGLMvlwstrfwFAT--PMTDNLFSRFGLIMLIGLVAK 924
Cdd:PRK15127   869 SGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALL--------AATfrGLTNDVYFQVGLLTTIGLSAK 940
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  925 NGILIVEFANQL-QIEGKDAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIVVVGGLTLSTVITLF 1003
Cdd:PRK15127   941 NAILIVEFAKDLmDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIF 1020
                         1050
                   ....*....|.
gi 1387289088 1004 VIPVLYILLDR 1014
Cdd:PRK15127  1021 FVPVFFVVVRR 1031
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
7-1009 4.25e-102

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 345.21  E-value: 4.25e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088    7 SIKRPVVSLVASIFVVLLGVLSFMSLPVREYP-MTDTAVIsVRTSYRGASAEVVETKITEPIEKELASIDGIRNIQSTSQ 85
Cdd:TIGR00914    9 SVAQRWLVLLATLVMAILGIWSYNRLPIDAVPdITNVQVQ-INTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSR 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088   86 EESSRITIEFNLDRNIDEAANDVRDRMSRARRRLPDDIDepiiTKADPDATPV-----ITLSFNSD-------RYSRLEL 153
Cdd:TIGR00914   88 YGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVS----PEMGPISTGLgeiflYTVEAEEGarkkdggAYTLTDL 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  154 VELVEQLAIQRIQTVPGVGSV-TVRGPRFAMRMWIDSDRLAAYELTVADVEAALRAQNVEVPSGRIESSAREFPLRMEGR 232
Cdd:TIGR00914  164 RTIQDWIIRPQLRTVPGVAEVnSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQ 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  233 MQEVVDFENLVLVTRGDYQVKFSDIGRVELGPEDYRSETYFKGHLTVSVAVVRQPNANLLDVVNGVKAVIPAVRTDLPPG 312
Cdd:TIGR00914  244 VQSMDDIRNIVIATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTLPEG 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  313 VNVQVAFDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINIltLLALVL 392
Cdd:TIGR00914  324 VEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANL--MSLGAL 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  393 AVGLVVDDAIVVLENIYRRMEHGENA----------IHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQSGQTGRLFYEFG 462
Cdd:TIGR00914  402 DFGLIVDGAVVIVENAHRRLAEAQHHhgrqltlkerLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMA 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  463 ITLAVAVLVSAFVALTLTPMLCsrvlhpvkvvnGVKKHGWLYDKTEPFFVWFNKCYERLLRVATNNKALVLLAALAFSCA 542
Cdd:TIGR00914  482 FTVVLALAGAMILSLTFVPAAV-----------ALFIRGKVAEKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVL 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  543 GFWLYTKLQRELTPAEDRGVF---TARL--ISPVGSTAEYLRLysydmEQMVLKVPEIDRTYHRTgdgGRAWIYTTLVP- 616
Cdd:TIGR00914  551 VVWIASRVGGEFIPSLNEGDLayqALRIpgTSLAQSVAMQQTL-----EKLIKSFPEVARVFAKT---GTAEIATDPMPp 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  617 --------------WEDRKRKTQDVSADLRRQFAREVTGGQAIVSAVRS-----FGGGRGAAGVTmvLLGSEFNELQRLG 677
Cdd:TIGR00914  623 nasdtyiilkpesqWPEGKKTKEDLIEEIQEATVRIPGNNYEFTQPIQMrfnelISGVRSDVAVK--VFGDDLDDLDATA 700
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  678 ALFVKDMLESGHFVQPRVDPSPTKPQLQLRIDRAKAADMRVKVSDIATTLESLLGSRRVTEFQRGNQQYYVVVQIEDAKR 757
Cdd:TIGR00914  701 EKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLR 780
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  758 ATPSDLARLYVRSTEGNL-----VQLSNLVSWTEDTVAESYRHFDRMRSVVVSSQLSpGFTIGDAVDYLNARGAD--LLT 830
Cdd:TIGR00914  781 ESPQALRQLPIPLPLSEDarkqfIPLSDVADLRVSPGPNQISRENGKRRVVVSANVR-GRDLGSFVDDAKKAIAEqvKLP 859
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  831 PGYTIAWDGETrEYIESGNDTYMLF-GLALLFTFLILAAQFESWIHPVTIFSGVVLAIAGGLMVLWstrfWFATPMTdnL 909
Cdd:TIGR00914  860 PGYWITWGGQF-EQLQSATKRLQIVvPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALW----LRGIPLS--I 932
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  910 FSRFGLIMLIGLVAKNGILIVEFANQLQIEGKDAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGAETRNPMGIV 989
Cdd:TIGR00914  933 SAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATV 1012
                         1050      1060
                   ....*....|....*....|
gi 1387289088  990 VVGGLTLSTVITLFVIPVLY 1009
Cdd:TIGR00914 1013 VIGGIITATLLTLFVLPALY 1032
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
298-1015 1.32e-20

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 98.01  E-value: 1.32e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  298 VKAVIPAVRTDL----PPGVNVQV---AFDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIG 370
Cdd:COG1033    179 RKEVVAEIRAIIakyeDPGVEVYLtgfPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIW 258
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  371 TFTVMSILGFSINILTLLALVLAVGLVVDDAIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFQ 450
Cdd:COG1033    259 TLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFS 338
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  451 SGQTGRlfyEFGITLAVAVLVSAFVALTLTPMLCSRVLHPVKVVNGVKKHGWLydktepffvwfNKCYERLLRVATNNKA 530
Cdd:COG1033    339 DIPPIR---DFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPEL-----------GRLLAKLARFVLRRPK 404
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  531 LVLLAALAFSCAGFWLYTKLQreltpaedrgvftarlispvgstaeylrlYSYDMEQMVlkvpeidrtyhrtgdggrawi 610
Cdd:COG1033    405 VILVVALVLAVVSLYGISRLK-----------------------------VEYDFEDYL--------------------- 434
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  611 yttlvpwedrkRKTQDVSADLRrqFAREVTGGQAIVSAVRSFGGGRGAagvtmvllgSEFNELQRLGALfvKDMLESghf 690
Cdd:COG1033    435 -----------PEDSPIRQDLD--FIEENFGGSDPLEVVVDTGEPDGL---------KDPEVLKEIDRL--QDYLES--- 487
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  691 vQPRVDpsptkpqlqlridrakaadmrvKVSDIATTLESLLGSrrvteFQRGNQQYYVVVQIEDakratpsdlarlyvrs 770
Cdd:COG1033    488 -LPEVG----------------------KVLSLADLVKELNQA-----LNEGDPKYYALPESRE---------------- 523
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  771 tegNLVQLSNLVSWTEDTVAESYRHFDRMRS-VVVSSQLSPGFTIGDAVDYLNARGADLL-TPGYTIAWDGETR------ 842
Cdd:COG1033    524 ---LLAQLLLLLSSPPGDDLSRFVDEDYSAArVTVRLKDLDSEEIKALVEEVRAFLAENFpPDGVEVTLTGSAVlfaain 600
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  843 EYIESGNdtYMLFGLALLFTFLILAAQFESWIHPV--TIFSGVVLAIAGGLMVLWSTRFWFATPMtdnLFSrfgliMLIG 920
Cdd:COG1033    601 ESVIESQ--IRSLLLALLLIFLLLLLAFRSLRLGLisLIPNLLPILLTFGLMGLLGIPLNIATAV---VAS-----IALG 670
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  921 LVAKNGILIVEFANQLQIEGKDAFTAAFQSATIRFRPILMTSIATILGAVPIAFATGAGaeTRNpMGIVVVGGLTLSTVI 1000
Cdd:COG1033    671 IGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPP--LAD-FGLLLALGLLVALLA 747
                          730
                   ....*....|....*
gi 1387289088 1001 TLFVIPVLYILLDRI 1015
Cdd:COG1033    748 ALLLLPALLLLLDPR 762
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
265-483 2.08e-13

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 74.51  E-value: 2.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  265 EDYRSETYFKGHLTVSVAVVRQpnANLLDVVNGVKAVIpaVRTDLPPGVNVQVAFDNSTF---VERSVKEVYKTILEASA 341
Cdd:COG1033    541 SRFVDEDYSAARVTVRLKDLDS--EEIKALVEEVRAFL--AENFPPDGVEVTLTGSAVLFaaiNESVIESQIRSLLLALL 616
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  342 LVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVVDDAIVVLENIYRRMEHGENAIHA 421
Cdd:COG1033    617 LIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEA 696
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387289088  422 AIFGTRQVAFAVIATTLTLAAVFLPVAFQSgqtGRLFYEFGITLAVAVLVSAFVALTLTPML 483
Cdd:COG1033    697 IRRALRTTGKAILFTSLTLAAGFGVLLFSS---FPPLADFGLLLALGLLVALLAALLLLPAL 755
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
816-1046 2.77e-12

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 71.04  E-value: 2.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  816 DAVDYLNARGADLLTPGYTI------AWDGETREYIESgnDTYMLFGLALLFTFLILAAQFESWIHPVTIFSGVVLAIAG 889
Cdd:COG1033    181 EVVAEIRAIIAKYEDPGVEVyltgfpVLRGDIAEAIQS--DLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIW 258
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  890 --GLMVLWSTRFwfaTPMTDNLFsrfglIMLIGLVAKNGILIVEFANQLQIEGKDAFTAAFQSATIRFRPILMTSIATIL 967
Cdd:COG1033    259 tlGLMGLLGIPL---SPLTILVP-----PLLLAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAI 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  968 GavpiaFAT------GAGAEtrnpMGIVVVGGLTLSTVITLFVIPVLYILLDRicvkvtGKSSAYGLKRAEEIDRETRTI 1041
Cdd:COG1033    331 G-----FLSllfsdiPPIRD----FGIVAAIGVLLAFLTSLTLLPALLSLLPR------PKPKTRRLKKPPELGRLLAKL 395

                   ....*
gi 1387289088 1042 GSGVH 1046
Cdd:COG1033    396 ARFVL 400
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
291-483 9.05e-11

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 66.01  E-value: 9.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  291 LLDVVNGVKAVIPavRTDLPPGVNVQVAFD---NSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVS 367
Cdd:TIGR00921  153 VVPIYNDVERSLE--RTNPPSGKFLDVTGSpaiNYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFG 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  368 IIGTFTVMSILGFSINILTLLALVLAVGLVVDDAIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPV 447
Cdd:TIGR00921  231 VAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAAL 310
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1387289088  448 aFQSGQtgRLFYEFGITLAVAVLVSAFVALTLTPML 483
Cdd:TIGR00921  311 -ALSEF--PMVSEFGLGLVAGLITAYLLTLLVLPAL 343
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
252-483 2.37e-10

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 64.99  E-value: 2.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  252 VKFSDIGRVELGPEDYRSETYFKGHLTVSVAVvrqpNANLLDVVNGVKAVIPAV-RTDLPPGVNVQVAFDNSTFV---ER 327
Cdd:TIGR00833   95 ISVVDFWGPPEAAEGLRSDDGKATIIIVNLAG----EKGQKEAQEAINAVRRIVeQTNAPDGLTVHVTGPLATIAdilES 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  328 SVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVV-----DDAI 402
Cdd:TIGR00833  171 GDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNAQTTVLLTALVigagtDYAV 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  403 VVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAAVFLPVAFqsgqtGRL--FYEFGITLAVAVLVSAFVALTLT 480
Cdd:TIGR00833  251 FLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSL-----ARLpsFKTLGVSCAVGVLVALLNAVTLT 325

                   ...
gi 1387289088  481 PML 483
Cdd:TIGR00833  326 PAL 328
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
306-483 7.51e-08

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 56.38  E-value: 7.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  306 RTDLPPGVNVQVAFDNSTFVE--RSVKEVYKTI-LEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTVMSILGFSI 382
Cdd:TIGR00921  540 HEHPPPGVKVGVTGLPVAFAEmhELVNEGMRRMtIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPS 619
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  383 NILTLLALVLAVGLVVDDAIVVLENIY-RRMEHG-ENAIHAAIfgtRQVAFAVIATTLTLAAVFLpvAFQSGQTGrLFYE 460
Cdd:TIGR00921  620 FLAMATTISIILGLGMDYSIHLAERYFeERKEHGpKEAITHTM---ERTGPGILFSGLTTAGGFL--SLLLSHFP-IMRN 693
                          170       180
                   ....*....|....*....|...
gi 1387289088  461 FGITLAVAVLVSAFVALTLTPML 483
Cdd:TIGR00921  694 FGLVQGIGVLSSLTAALVVFPAL 716
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
296-485 8.87e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 52.29  E-value: 8.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  296 NGVKAVIPAV-RTDLPPGVNVQVAFDNSTFV---ERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGT 371
Cdd:pfam03176  104 ESVAAVRDAVeQAPPPEGLKAYLTGPAATVAdlrDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAA 183
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  372 FTVMSILG---------FSINILTLLALVLAVglvvDDAIVVLENIYRRMEHGENAIHAAIFGTRQVAFAVIATTLTLAA 442
Cdd:pfam03176  184 QGLVAILAhilgiglstFALNLLVVLLIAVGT----DYALFLVSRYREELRAGEDREEAVIRAVRGTGKVVTAAGLTVAI 259
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1387289088  443 VFLPVAFQSGqtgRLFYEFGITLAVAVLVSAFVALTLTPMLCS 485
Cdd:pfam03176  260 AMLALSFARL---PVFAQVGPTIAIGVLVDVLAALTLLPALLA 299
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
844-1043 1.49e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 52.53  E-value: 1.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  844 YIESGNDTYMLFGLALLFTFLILAAQFESWIHPVTifsGVVLAIAGGLMVLwSTRFWFATPMTdnLFSRFGLIMLIGLVA 923
Cdd:TIGR00921  188 EREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLL---PLVIILFGVAWVL-GIMGWLGIPLY--ATTLLAVPMLIGVGI 261
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  924 KNGIlivEFANQLQIE---GKDAFTAAFQSATIRFRPILMTSIATILGAVPIaFATGAGAETRnpMGIVVVGGLTLSTVI 1000
Cdd:TIGR00921  262 DYGI---QTLNRYEEErdiGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAAL-ALSEFPMVSE--FGLGLVAGLITAYLL 335
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1387289088 1001 TLFVIPVLYILLDRICVKVTGKSSAYGLKRAeEIDRETRTIGS 1043
Cdd:TIGR00921  336 TLLVLPALLQSIDIGREKVKKEIIAIGGKSS-EIEEELSKVLS 377
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
298-481 1.11e-05

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 49.38  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  298 VKAVIPAVRTDLPPGVNVQV---AFDNSTFVERSVKEVYKTILEASALVILIIFLFLRNWRATLVPLVAIPVSIIGTFTV 374
Cdd:COG2409    134 VDALRDAVAAAPAPGLTVYVtgpAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGL 213
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  375 MSILG-------FSINILtllalvlavglvvddAIVVL---------------ENIYRRMEHGEnAIHAAIFGT-RQVAF 431
Cdd:COG2409    214 LALLAaftdvssFAPNLL---------------TMLGLgvgidyalflvsryrEELRAGEDREE-AVARAVATAgRAVLF 277
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1387289088  432 A---VIATTLTLAAVFLPVaFQSgqtgrlfyeFGITLAVAVLVSAFVALTLTP 481
Cdd:COG2409    278 SgltVAIALLGLLLAGLPF-LRS---------MGPAAAIGVAVAVLAALTLLP 320
secD TIGR01129
protein-export membrane protein SecD; Members of this family are highly variable in length ...
326-480 9.48e-04

protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273456 [Multi-domain]  Cd Length: 397  Bit Score: 42.66  E-value: 9.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  326 ERSV-----KEVYKTILEASALVILIIFLFLRNWRAT--LVPLVAIPVSIIGTFTVMSILGFSINILTLLALVLAVGLVV 398
Cdd:TIGR01129  235 ERTIgpslgADSIEAGIKAGLIGLVLVLVFMILYYRLfgLIAAIALVINIVLILAILSAFGATLTLPGIAGLILTIGMAV 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387289088  399 DDAIVVLENIYRRMEHG---ENAIHAAIFGTRQVAFAVIATTLtLAAVFLpVAFQSGQT-GrlfyeFGITLAVAVLVSAF 474
Cdd:TIGR01129  315 DANVLIYERIKEELRLGksvRQAIEAGFERAFSTIFDANITTL-IAALIL-YVFGTGPVkG-----FAVTLAIGIIASLF 387

                   ....*.
gi 1387289088  475 VALTLT 480
Cdd:TIGR01129  388 TALVFT 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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