|
Name |
Accession |
Description |
Interval |
E-value |
| Gnd |
COG0362 |
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ... |
2-466 |
0e+00 |
|
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 440131 [Multi-domain] Cd Length: 467 Bit Score: 959.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 2 SKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAENP-GKKLVPYYTVKEFVESLETPRRILLMVKAGAGT 80
Cdd:COG0362 1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGkGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 81 DAAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA 160
Cdd:COG0362 81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 161 AVAeDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFT 240
Cdd:COG0362 161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 241 KKD-EDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGP-QAQPAGDKAEFI 318
Cdd:COG0362 240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPeAAPFEGDKEAFI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 319 EKVRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIAD 398
Cdd:COG0362 320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352185516 399 DYQQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEW 466
Cdd:COG0362 400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
|
|
| PRK09287 |
PRK09287 |
NADP-dependent phosphogluconate dehydrogenase; |
14-468 |
0e+00 |
|
NADP-dependent phosphogluconate dehydrogenase;
Pssm-ID: 236453 [Multi-domain] Cd Length: 459 Bit Score: 949.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 14 MGRNLALNIESRGYTVSIFNRSREKTEEVIAE-NPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLD 92
Cdd:PRK09287 1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 93 KGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVAEDGEPCVTY 172
Cdd:PRK09287 81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 173 IGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTKKD-EDGNYLVD 251
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 252 VILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIV 331
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 332 SYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQALRDVVAYA 411
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1352185516 412 VQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD 468
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSE 457
|
|
| gnd |
TIGR00873 |
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ... |
5-468 |
0e+00 |
|
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]
Pssm-ID: 273314 [Multi-domain] Cd Length: 467 Bit Score: 865.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 5 QIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAE-NPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAA 83
Cdd:TIGR00873 1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEeAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 84 IDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVA 163
Cdd:TIGR00873 81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 164 eDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTKKD 243
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 244 EDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAG-DKAEFIEKVR 322
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGvDKEEFIEDVR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 323 RALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQ 402
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352185516 403 ALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEG--VFHTEWLD 468
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTG 467
|
|
| 6PGD |
pfam00393 |
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ... |
179-466 |
0e+00 |
|
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.
Pssm-ID: 459797 Cd Length: 290 Bit Score: 574.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 179 GHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTKKD-EDGNYLVDVILDEA 257
Cdd:pfam00393 1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDpEDGKPLVDKILDKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 258 ANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGP-QAQPAGDKAEFIEKVRRALYLGKIVSYAQG 336
Cdd:pfam00393 81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPpPALFEGDKEAFIEDLRQALYASKIISYAQG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 337 FSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQALRDVVAYAVQNGI 416
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1352185516 417 PVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEW 466
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| Gnd |
COG0362 |
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ... |
2-466 |
0e+00 |
|
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 440131 [Multi-domain] Cd Length: 467 Bit Score: 959.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 2 SKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAENP-GKKLVPYYTVKEFVESLETPRRILLMVKAGAGT 80
Cdd:COG0362 1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGkGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 81 DAAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA 160
Cdd:COG0362 81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 161 AVAeDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFT 240
Cdd:COG0362 161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 241 KKD-EDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGP-QAQPAGDKAEFI 318
Cdd:COG0362 240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPeAAPFEGDKEAFI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 319 EKVRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIAD 398
Cdd:COG0362 320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352185516 399 DYQQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEW 466
Cdd:COG0362 400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
|
|
| PRK09287 |
PRK09287 |
NADP-dependent phosphogluconate dehydrogenase; |
14-468 |
0e+00 |
|
NADP-dependent phosphogluconate dehydrogenase;
Pssm-ID: 236453 [Multi-domain] Cd Length: 459 Bit Score: 949.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 14 MGRNLALNIESRGYTVSIFNRSREKTEEVIAE-NPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLD 92
Cdd:PRK09287 1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 93 KGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVAEDGEPCVTY 172
Cdd:PRK09287 81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 173 IGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTKKD-EDGNYLVD 251
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 252 VILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIV 331
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 332 SYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQALRDVVAYA 411
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1352185516 412 VQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD 468
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSE 457
|
|
| gnd |
TIGR00873 |
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ... |
5-468 |
0e+00 |
|
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]
Pssm-ID: 273314 [Multi-domain] Cd Length: 467 Bit Score: 865.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 5 QIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAE-NPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAA 83
Cdd:TIGR00873 1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEeAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 84 IDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVA 163
Cdd:TIGR00873 81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 164 eDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTKKD 243
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 244 EDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAG-DKAEFIEKVR 322
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGvDKEEFIEDVR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 323 RALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQ 402
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352185516 403 ALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEG--VFHTEWLD 468
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTG 467
|
|
| PTZ00142 |
PTZ00142 |
6-phosphogluconate dehydrogenase; Provisional |
6-466 |
0e+00 |
|
6-phosphogluconate dehydrogenase; Provisional
Pssm-ID: 240287 [Multi-domain] Cd Length: 470 Bit Score: 638.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 6 IGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVI--AENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAA 83
Cdd:PTZ00142 4 IGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVkkAKEGNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAVDET 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 84 IDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVA 163
Cdd:PTZ00142 84 IDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCSAKV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 164 EDgEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTKKD 243
Cdd:PTZ00142 164 GD-SPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILAKKD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 244 EDGN-YLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQA---QPAGDKAEFIE 319
Cdd:PTZ00142 243 DLGEeHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNPankTETEDKKYFID 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 320 KVRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADD 399
Cdd:PTZ00142 323 DLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDELKN 402
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352185516 400 YQQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEW 466
Cdd:PTZ00142 403 KQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAFHTNW 469
|
|
| PLN02350 |
PLN02350 |
phosphogluconate dehydrogenase (decarboxylating) |
1-468 |
0e+00 |
|
phosphogluconate dehydrogenase (decarboxylating)
Pssm-ID: 215200 [Multi-domain] Cd Length: 493 Bit Score: 635.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 1 MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVI--AENPGK-KLVPYYTVKEFVESLETPRRILLMVKAG 77
Cdd:PLN02350 4 AALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVerAKKEGNlPLYGFKDPEDFVLSIQKPRSVIILVKAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 78 AGTDAAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILT 157
Cdd:PLN02350 84 APVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 158 KIAAVAEDGePCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKD 237
Cdd:PLN02350 164 KVAAQVDDG-PCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITAD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 238 IFTKKDEDGN-YLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGP------QAQP 310
Cdd:PLN02350 243 IFSVKDDKGDgYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAgledilSADS 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 311 AGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLA 390
Cdd:PLN02350 323 GVDKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVD 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352185516 391 PYFKQIADDYQQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD 468
Cdd:PLN02350 403 PEFAKEMVERQAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSFHTEWTK 480
|
|
| 6PGD |
pfam00393 |
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ... |
179-466 |
0e+00 |
|
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.
Pssm-ID: 459797 Cd Length: 290 Bit Score: 574.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 179 GHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTKKD-EDGNYLVDVILDEA 257
Cdd:pfam00393 1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDpEDGKPLVDKILDKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 258 ANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGP-QAQPAGDKAEFIEKVRRALYLGKIVSYAQG 336
Cdd:pfam00393 81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPpPALFEGDKEAFIEDLRQALYASKIISYAQG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 337 FSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQALRDVVAYAVQNGI 416
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1352185516 417 PVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEW 466
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
|
|
| PRK09599 |
PRK09599 |
NADP-dependent phosphogluconate dehydrogenase; |
5-304 |
5.88e-92 |
|
NADP-dependent phosphogluconate dehydrogenase;
Pssm-ID: 236582 [Multi-domain] Cd Length: 301 Bit Score: 281.25 E-value: 5.88e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 5 QIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAENpgkkLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAI 84
Cdd:PRK09599 2 QLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEG----ATGADSLEELVAKLPAPRVVWLMVPAGEITDATI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 85 DSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVAE 164
Cdd:PRK09599 78 DELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRAE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 165 DGepcVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLK-GGLNLTNEELAQTfteWNNGE-LSSYLIDITKDIFtKK 242
Cdd:PRK09599 158 DG---YLHAGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEaSRFDLDLAAVAEV---WRRGSvIRSWLLDLTADAL-AE 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352185516 243 DEDgnylVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYiSSLKDQRVAAsKVLS 304
Cdd:PRK09599 231 DPK----LDEISGYVEDSGEGRWTVEEAIDLAVPAPVIAAALFMRF-RSRQEDSFAD-KVVA 286
|
|
| YqeC |
COG1023 |
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism]; |
5-304 |
1.21e-90 |
|
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
Pssm-ID: 440646 [Multi-domain] Cd Length: 300 Bit Score: 277.74 E-value: 1.21e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 5 QIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAENpgkkLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAI 84
Cdd:COG1023 2 QIGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAALAAEG----ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 85 DSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVAE 164
Cdd:COG1023 78 EELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 165 DGepCVtYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGG---LNltneeLAQTFTEWNNGE-LSSYLIDITKDIFt 240
Cdd:COG1023 158 NG--YL-HCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASefdLD-----LAEVAEVWRRGSvIRSWLLDLTADAL- 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352185516 241 KKDEDgnylvdviLDE----AANKGTGKWTSQSALDLGEPLSLITESVFARYiSSLKDQRVAAsKVLS 304
Cdd:COG1023 229 AEDPK--------LEGisgyVEDSGEGRWTVEEAIELGVPAPVITAALFARF-RSRQEDSFAD-KVLA 286
|
|
| NAD_binding_2 |
pfam03446 |
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ... |
5-174 |
2.21e-66 |
|
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.
Pssm-ID: 427298 [Multi-domain] Cd Length: 159 Bit Score: 210.02 E-value: 2.21e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 5 QIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAENpgkkLVPYYTVKEFVESLetpRRILLMVKAGAGTDAAI 84
Cdd:pfam03446 1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAG----AIAAASPAEFVAGL---DVVITMVPAGAAVDAVI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 85 DS--LKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAPILTKIAA 161
Cdd:pfam03446 74 FGegLLPGLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMGA 153
|
170
....*....|...
gi 1352185516 162 vaedgepCVTYIG 174
Cdd:pfam03446 154 -------CVTYIG 159
|
|
| gnd_rel |
TIGR00872 |
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ... |
5-304 |
2.11e-57 |
|
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]
Pssm-ID: 273313 [Multi-domain] Cd Length: 298 Bit Score: 191.60 E-value: 2.11e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 5 QIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEvIAENPGKKLVpyyTVKEFVESLETPRRILLMVKAGAgTDAAI 84
Cdd:TIGR00872 2 QLGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVKA-MKEDRTTGVA---NLRELSQRLSAPRVVWVMVPHGI-VDAVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 85 DSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAaVAE 164
Cdd:TIGR00872 77 EELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVA-PEE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 165 DGepcVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGG-LNLTNEELAQTfteWNNGE-LSSYLIDITKDIFtKK 242
Cdd:TIGR00872 156 QG---YLYCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSqFDFDIPEVARV---WRRGSvIRSWLLDLTAIAF-RE 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352185516 243 DEDgnylVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDqrVAASKVLS 304
Cdd:TIGR00872 229 SPD----LAEFSGRVSDSGEGRWTVIAAIDLGVPAPVIATSLQSRFASRDLD--DFANKVLA 284
|
|
| MmsB |
COG2084 |
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ... |
3-210 |
3.30e-26 |
|
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];
Pssm-ID: 441687 [Multi-domain] Cd Length: 285 Bit Score: 107.51 E-value: 3.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 3 KQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAEnpGKKLVPyyTVKEFVESLETprrILLMVKAGA---- 78
Cdd:COG2084 1 MMKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAA--GARVAA--SPAEAAAAADV---VITMLPDDAavee 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 79 ---GTDAAIDSLKPyldkGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAP 154
Cdd:COG2084 74 vllGEDGLLAALRP----GAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARP 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1352185516 155 ILTKIAAVaedgepcVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLL-KGGLNL 210
Cdd:COG2084 150 VLEAMGKR-------IVHVGDAGAGQAAKLANNLLLAGTMAALAEALALAeKAGLDP 199
|
|
| garR |
PRK11559 |
tartronate semialdehyde reductase; Provisional |
4-209 |
6.16e-16 |
|
tartronate semialdehyde reductase; Provisional
Pssm-ID: 183197 [Multi-domain] Cd Length: 296 Bit Score: 78.17 E-value: 6.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 4 QQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAENPGKKLVPyytvKEFVESLETprrILLM------VKAG 77
Cdd:PRK11559 3 MKVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAETASTA----KAVAEQCDV---IITMlpnsphVKEV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 78 A-GTDAAIDSLKPyldkGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAPI 155
Cdd:PRK11559 76 AlGENGIIEGAKP----GTVVIDMSSIAPLASREIAAALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDL 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1352185516 156 LTKIAAvaedgepCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSL-LKGGLN 209
Cdd:PRK11559 152 MKAMAG-------SVVHTGDIGAGNVTKLANQVIVALNIAAMSEALVLaTKAGVN 199
|
|
| PRK15059 |
PRK15059 |
2-hydroxy-3-oxopropionate reductase; |
5-200 |
4.79e-06 |
|
2-hydroxy-3-oxopropionate reductase;
Pssm-ID: 185019 [Multi-domain] Cd Length: 292 Bit Score: 48.09 E-value: 4.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 5 QIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEevIAENPGKKLVPYYTVKEFVESL-----ETPRRILLMVKAGAG 79
Cdd:PRK15059 2 KLGFIGLGIMGTPMAINLARAGHQLHVTTIGPVADE--LLSLGAVSVETARQVTEASDIIfimvpDTPQVEEVLFGENGC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 80 TDAAIdslkpyldKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAPILTK 158
Cdd:PRK15059 80 TKASL--------KGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPLFEL 151
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1352185516 159 IAAvaedgepCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEA 200
Cdd:PRK15059 152 LGK-------NITLVGGNGDGQTCKVANQIIVALNIEAVSEA 186
|
|
| ApbA |
pfam02558 |
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ... |
6-98 |
8.87e-04 |
|
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.
Pssm-ID: 426831 [Multi-domain] Cd Length: 147 Bit Score: 39.52 E-value: 8.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352185516 6 IGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEE-----VIAENPGKKLVPYYTVKEFVESLETPRRILLMVKAgAGT 80
Cdd:pfam02558 1 IAILGAGAIGSLLGARLAKAGHDVTLILRGAELAAIkknglRLTSPGGERIVPPPAVTSASESLGPIDLVIVTVKA-YQT 79
|
90
....*....|....*...
gi 1352185516 81 DAAIDSLKPYLDKGDIII 98
Cdd:pfam02558 80 EEALEDIAPLLGPNTVVL 97
|
|
|