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Conserved domains on  [gi|1337408270|gb|AUW47857|]
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AraC family transcriptional regulator (plasmid) [Rhizobium leguminosarum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10371 super family cl32508
transcriptional regulator MelR;
35-290 4.48e-45

transcriptional regulator MelR;


The actual alignment was detected with superfamily member PRK10371:

Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 154.98  E-value: 4.48e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270  35 PPVMAMPHWHAQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDDSLYAGAHLPLVYFFRLRLPISVSS 114
Cdd:PRK10371   35 PHIMPTSHWHGQVEVNVPFDGDVEYLINNEKVQINQGHITLFWACTPHQLTDPGNCRSMAIFNLPMHLFLSWPLDKDLIN 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 115 RLMKGETLLTSATDAADNENFTRWFRYANSGDAAKAQHAVDELLLRIERIAL---EPYSMTSQAiiSLEGDHPHPHSSRS 191
Cdd:PRK10371  115 HVTHGMVIKSLATQQLSPFEVRRWQQELNSPNEQIRQLAIDEIGLMLKRFSLsgwEPILVNKTS--RTHKNSVSRHAQFY 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 192 VARMCDFIAANFLHDIDSVDIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSIS 271
Cdd:PRK10371  193 VSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSS 272

                         250
                  ....*....|....*....
gi 1337408270 272 AFNKSFRHIAGMSPSDFRR 290
Cdd:PRK10371  273 RFYSTFGKYVGMSPQQYRK 291
 
Name Accession Description Interval E-value
PRK10371 PRK10371
transcriptional regulator MelR;
35-290 4.48e-45

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 154.98  E-value: 4.48e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270  35 PPVMAMPHWHAQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDDSLYAGAHLPLVYFFRLRLPISVSS 114
Cdd:PRK10371   35 PHIMPTSHWHGQVEVNVPFDGDVEYLINNEKVQINQGHITLFWACTPHQLTDPGNCRSMAIFNLPMHLFLSWPLDKDLIN 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 115 RLMKGETLLTSATDAADNENFTRWFRYANSGDAAKAQHAVDELLLRIERIAL---EPYSMTSQAiiSLEGDHPHPHSSRS 191
Cdd:PRK10371  115 HVTHGMVIKSLATQQLSPFEVRRWQQELNSPNEQIRQLAIDEIGLMLKRFSLsgwEPILVNKTS--RTHKNSVSRHAQFY 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 192 VARMCDFIAANFLHDIDSVDIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSIS 271
Cdd:PRK10371  193 VSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSS 272

                         250
                  ....*....|....*....
gi 1337408270 272 AFNKSFRHIAGMSPSDFRR 290
Cdd:PRK10371  273 RFYSTFGKYVGMSPQQYRK 291
cupin_MelR-like_N cd06997
AraC/XylS family transcriptional regulators similar to Escherichia coli MelR, N-terminal cupin ...
 28-105 1.92e-37

AraC/XylS family transcriptional regulators similar to Escherichia coli MelR, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators, including Escherichia coli MelR, a transcription factor that controls melibiose utilization. MelR is encoded by the melR gene and is essential for melibiose-dependent triggering of the melAB operon that encodes products needed for melibiose catabolism and transport. Expression of melR is autoregulated by MelR, which represses the melR promoter by binding to a target that overlaps the transcript start. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380401  Cd Length: 78  Bit Score: 127.88  E-value: 1.92e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1337408270  28 LQMFHAHPPVMAMPHWHAQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDDSLYAGAHLPLVYFFR 105
Cdd:cd06997     1 LQIEHRQPHIMPTPHWHGQVEVNIPFDGDVEYLINEHAVSLNAGHIGLFWGGLPHQLTDTGDCAIMAIFNLPLHHFFS 78
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
211-289 3.66e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 85.68  E-value: 3.66e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337408270  211 DIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFR 289
Cdd:smart00342   6 DLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
139-293 2.91e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 87.91  E-value: 2.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 139 FRYANSGDAAKAQHAVDELLLRIERIALEPYSMTSQAIISLEGDHPHPHSSRSVARMCDFIAANFLHDIDsvDIARAADL 218
Cdd:COG2207   103 LLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLE--ELARELGL 180

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1337408270 219 HPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFRRDIR 293
Cdd:COG2207   181 SPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLR 255
HTH_18 pfam12833
Helix-turn-helix domain;
212-290 5.14e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.56  E-value: 5.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 212 IARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSE-GANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFRR 290
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
 
Name Accession Description Interval E-value
PRK10371 PRK10371
transcriptional regulator MelR;
35-290 4.48e-45

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 154.98  E-value: 4.48e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270  35 PPVMAMPHWHAQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDDSLYAGAHLPLVYFFRLRLPISVSS 114
Cdd:PRK10371   35 PHIMPTSHWHGQVEVNVPFDGDVEYLINNEKVQINQGHITLFWACTPHQLTDPGNCRSMAIFNLPMHLFLSWPLDKDLIN 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 115 RLMKGETLLTSATDAADNENFTRWFRYANSGDAAKAQHAVDELLLRIERIAL---EPYSMTSQAiiSLEGDHPHPHSSRS 191
Cdd:PRK10371  115 HVTHGMVIKSLATQQLSPFEVRRWQQELNSPNEQIRQLAIDEIGLMLKRFSLsgwEPILVNKTS--RTHKNSVSRHAQFY 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 192 VARMCDFIAANFLHDIDSVDIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSIS 271
Cdd:PRK10371  193 VSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSS 272

                         250
                  ....*....|....*....
gi 1337408270 272 AFNKSFRHIAGMSPSDFRR 290
Cdd:PRK10371  273 RFYSTFGKYVGMSPQQYRK 291
cupin_MelR-like_N cd06997
AraC/XylS family transcriptional regulators similar to Escherichia coli MelR, N-terminal cupin ...
 28-105 1.92e-37

AraC/XylS family transcriptional regulators similar to Escherichia coli MelR, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators, including Escherichia coli MelR, a transcription factor that controls melibiose utilization. MelR is encoded by the melR gene and is essential for melibiose-dependent triggering of the melAB operon that encodes products needed for melibiose catabolism and transport. Expression of melR is autoregulated by MelR, which represses the melR promoter by binding to a target that overlaps the transcript start. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380401  Cd Length: 78  Bit Score: 127.88  E-value: 1.92e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1337408270  28 LQMFHAHPPVMAMPHWHAQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDDSLYAGAHLPLVYFFR 105
Cdd:cd06997     1 LQIEHRQPHIMPTPHWHGQVEVNIPFDGDVEYLINEHAVSLNAGHIGLFWGGLPHQLTDTGDCAIMAIFNLPLHHFFS 78
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
211-289 3.66e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 85.68  E-value: 3.66e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337408270  211 DIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFR 289
Cdd:smart00342   6 DLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
139-293 2.91e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 87.91  E-value: 2.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 139 FRYANSGDAAKAQHAVDELLLRIERIALEPYSMTSQAIISLEGDHPHPHSSRSVARMCDFIAANFLHDIDsvDIARAADL 218
Cdd:COG2207   103 LLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLE--ELARELGL 180

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1337408270 219 HPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFRRDIR 293
Cdd:COG2207   181 SPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLR 255
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 173-290 6.00e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 87.91  E-value: 6.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 173 SQAIISLegdHPHPHSSRSVARMCDFIAANFLHDIDSVDIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLM 252
Cdd:COG4977   196 AQFSPLL---VPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLE 272

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1337408270 253 SEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFRR 290
Cdd:COG4977   273 TTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRR 310
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 180-300 2.01e-19

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 87.03  E-value: 2.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 180 EGDHPHPHSSRSVARMCDFIAANFLHDIDSVDIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLmSEGANVL 259
Cdd:COG2169    74 DLAPGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLSVT 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1337408270 260 QVAMDSGFGSISAFNKSFRHIAGMSPSDFRRDIRLVTTVPA 300
Cdd:COG2169   153 DAAYAAGFGSLSRFYEAFKKLLGMTPSAYRRGGAGAAIRFA 193
HTH_18 pfam12833
Helix-turn-helix domain;
212-290 5.14e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.56  E-value: 5.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 212 IARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSE-GANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFRR 290
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
ftrA PRK09393
transcriptional activator FtrA; Provisional
 186-290 2.47e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 63.44  E-value: 2.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 186 PHSSRSVARMCDFIAANFLHDIDSVDIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDS 265
Cdd:PRK09393  214 SRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERA 293

                          90       100
                  ....*....|....*....|....*
gi 1337408270 266 GFGSISAFNKSFRHIAGMSPSDFRR 290
Cdd:PRK09393  294 GFGSEESLRHHFRRRAATSPAAYRK 318
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
150-290 4.90e-10

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 59.22  E-value: 4.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 150 AQHAVDELLLRieRIALEPYSmtsqaiislegdHPHPHSSRsVARMCDFIAANFLHDIDSVDIARAADLHPKYAMNLFKR 229
Cdd:PRK10572  158 AMNLLERLLLR--CMEAIPES------------LHPPMDPR-VREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQ 222

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1337408270 230 STGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFRR 290
Cdd:PRK10572  223 QLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRA 283
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
199-302 1.74e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 54.53  E-value: 1.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 199 IAANFlhdiDSVDIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFR 278
Cdd:PRK13501  189 LGAYF----DMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFT 264

                          90       100
                  ....*....|....*....|....
gi 1337408270 279 HIAGMSPSDFRRDIRLVTTVPAGA 302
Cdd:PRK13501  265 REAGMTPRDYRQRFIRSPVLPAKN 288
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
26-90 7.35e-07

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 47.32  E-value: 7.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337408270  26 TALQMFHAH-PP--VMAMPHWH-AQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDD 90
Cdd:COG3837    26 TRLGVNLITlPPgaSSSPYHAHsAEEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPHRLRNRGDE 94
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 30-84 2.85e-06

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 44.40  E-value: 2.85e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1337408270  30 MFHAHPPVMAMPHWHA-QVEVNYVMRGTVHYRMSD-HEFRLNAGEMCLFWGGQPHQM 84
Cdd:cd02208     3 VVTLPPGTSSPPHWHPeQDEIFYVLSGEGELTLDDgETVELKAGDIVLIPPGVPHSF 59
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
227-289 1.22e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 45.82  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1337408270 227 FKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFR 289
Cdd:PRK13502  213 FRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
41-92 1.45e-05

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 42.91  E-value: 1.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1337408270  41 PHWHAQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDDSL 92
Cdd:COG1917    38 WHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPA 89
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 194-289 2.50e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 44.92  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 194 RMCDFIAANFLHDIDSVDIARAADLHPkyamNLFK---RSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSI 270
Cdd:PRK09978  146 RVCTVINNNIAHEWTLARIASELLMSP----SLLKkklREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSV 221

                          90
                  ....*....|....*....
gi 1337408270 271 SAFNKSFRHIAGMSPSDFR 289
Cdd:PRK09978  222 SYFIYVFRNYYGMTPTEYQ 240
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
228-289 2.68e-05

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 45.05  E-value: 2.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1337408270 228 KRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFR 289
Cdd:PRK13503  209 KQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIR 270
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
209-292 6.62e-05

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 41.45  E-value: 6.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 209 SVDIARAADLHPK-YAMNLFKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSD 287
Cdd:PRK10219   23 NIDVVAKKSGYSKwYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSD 102


                  ....*
gi 1337408270 288 FRRDI 292
Cdd:PRK10219  103 YRHRL 107
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
180-290 1.85e-04

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 42.47  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270 180 EGDHPHPHSSRSVARMCDFIAANFLHDIDSvdIARAADLHPKYAMNLFKRSTGMTLSKYVTLLRLSRAQAMLmSEGANVL 259
Cdd:PRK15435   75 DKANPQQHRLDKITHACRLLEQETPVTLEA--LADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREAL-AKGESVT 151

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1337408270 260 QVAMDSGFGSISAFNKSFRHIAGMSPSDFRR 290
Cdd:PRK15435  152 TSILNAGFPDSSSYYRKADETLGMTAKQFRH 182
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 41-84 3.95e-04

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 38.39  E-value: 3.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1337408270  41 PHWHA-QVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQM 84
Cdd:pfam07883  13 PHRHPgEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRF 57
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
227-289 7.11e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 40.86  E-value: 7.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1337408270 227 FKRSTGMTLSKYVTLLRLSRAQAMLMSEGANVLQVAMDSGFGSISAFNKSFRHIAGMSPSDFR 289
Cdd:PRK13500  243 FRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWR 305
cupin_bxe_c0505 cd06980
uncharacterized protein bxe_c0505, cupin domain; This family includes mostly bacterial ...
 30-90 1.12e-03

uncharacterized protein bxe_c0505, cupin domain; This family includes mostly bacterial proteins homologous to bxe_c0505, a Burkholderia xenovorans protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380385 [Multi-domain]  Cd Length: 105  Bit Score: 37.93  E-value: 1.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337408270  30 MFHAH-------PPVMAMPHWH-AQVEVNYVMRGTVHYRMSDH-EFRLNAGEMCLFWGGQPHQMDESSDD 90
Cdd:cd06980    20 RVGAHviratggGEGPTGWHYHdCDFQMVYVLKGWVKFEFEGGgEVRLEAGDCVYQPPGIRHNVLDYSDD 89
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 252-290 1.16e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.98  E-value: 1.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1337408270 252 MSEGANVLQVAMDSGFgSISAFNKSFRHIAGMSPSDFRR 290
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 41-82 1.78e-03

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 37.80  E-value: 1.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1337408270  41 PHWHAQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPH 82
Cdd:pfam02311  18 PHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPH 59
cupin_Lmo2851-like_N cd06996
AraC/XylS family transcriptional regulators similar to Listeria monocytogenes Lmo2851 protein, ...
 39-90 2.10e-03

AraC/XylS family transcriptional regulators similar to Listeria monocytogenes Lmo2851 protein, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included is Listeria monocytogenes Lmo2851 protein, whose function is unknown. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380400 [Multi-domain]  Cd Length: 87  Bit Score: 36.40  E-value: 2.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1337408270  39 AMP-HWHAQVEVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDD 90
Cdd:cd06996    25 DYPlHTHNFLEINYMYSGSCTQIVNGQEITLKEGDLLLLDQGSTHSIKALGED 77
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
41-92 5.82e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 35.89  E-value: 5.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1337408270  41 PHWHAQV-EVNYVMRGTVHYRMSDHEFRLNAGEMCLFWGGQPHQMDESSDDSL 92
Cdd:COG0662    42 LHVHPHRdEFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHRLRNPGDEPL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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