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Conserved domains on  [gi|1307925815|gb|AUE17136|]
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transposase [Bifidobacterium breve]

Protein Classification

transposase family protein( domain architecture ID 1750073)

transposase family protein might bind to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0006313
PubMed:  21439812

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS5_3 super family cl41332
IS5 family transposase;
1-124 2.49e-23

IS5 family transposase;


The actual alignment was detected with superfamily member NF033580:

Pssm-ID: 468097 [Multi-domain]  Cd Length: 257  Bit Score: 91.10  E-value: 2.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307925815   1 MASDGESTVVEIHLSPGDEHDAAHGRRSMAALGASVGAHP---LMGRAYERDSTRLPAESFGLTPVVPPKRNRtAPWDYD 77
Cdd:NF033580  132 IAVDALGLPLAFVLTGANVHDSKGALPLLDGLPVLRPPRPkhlLADKGYDSDALRAALRERGAVPVIPRRRNR-LRPAYD 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1307925815  78 REAHKGRNMVERVFNRMKHHRKAATRHDRLDETFLANLQLIPIAIYL 124
Cdd:NF033580  211 FRLYKKRWVVERTFAWLKRFRRLATRYEKLARNFLAFVHLACIRIWL 257
 
Name Accession Description Interval E-value
transpos_IS5_3 NF033580
IS5 family transposase;
1-124 2.49e-23

IS5 family transposase;


Pssm-ID: 468097 [Multi-domain]  Cd Length: 257  Bit Score: 91.10  E-value: 2.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307925815   1 MASDGESTVVEIHLSPGDEHDAAHGRRSMAALGASVGAHP---LMGRAYERDSTRLPAESFGLTPVVPPKRNRtAPWDYD 77
Cdd:NF033580  132 IAVDALGLPLAFVLTGANVHDSKGALPLLDGLPVLRPPRPkhlLADKGYDSDALRAALRERGAVPVIPRRRNR-LRPAYD 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1307925815  78 REAHKGRNMVERVFNRMKHHRKAATRHDRLDETFLANLQLIPIAIYL 124
Cdd:NF033580  211 FRLYKKRWVVERTFAWLKRFRRLATRYEKLARNFLAFVHLACIRIWL 257
DDE_Tnp_1_2 pfam13586
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
 44-125 4.09e-07

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.


Pssm-ID: 463928 [Multi-domain]  Cd Length: 90  Bit Score: 45.10  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307925815  44 RAYERDSTRLPAESFGLTPVVPPKR----NRTAPWDYDREAHKGRNMVERVFNRMKHHRKAATRHDRLDETFLANLQLIP 119
Cdd:pfam13586   5 RGYRTRHNREWLKERGIRASGPPLGrpakNKAQEKKQAREDEIARNVIEGKFGWFKRRRSLAKRYEKLASTFEGAIALTF 84


                  ....*.
gi 1307925815 120 IAIYLK 125
Cdd:pfam13586  85 LVINLR 90
 
Name Accession Description Interval E-value
transpos_IS5_3 NF033580
IS5 family transposase;
1-124 2.49e-23

IS5 family transposase;


Pssm-ID: 468097 [Multi-domain]  Cd Length: 257  Bit Score: 91.10  E-value: 2.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307925815   1 MASDGESTVVEIHLSPGDEHDAAHGRRSMAALGASVGAHP---LMGRAYERDSTRLPAESFGLTPVVPPKRNRtAPWDYD 77
Cdd:NF033580  132 IAVDALGLPLAFVLTGANVHDSKGALPLLDGLPVLRPPRPkhlLADKGYDSDALRAALRERGAVPVIPRRRNR-LRPAYD 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1307925815  78 REAHKGRNMVERVFNRMKHHRKAATRHDRLDETFLANLQLIPIAIYL 124
Cdd:NF033580  211 FRLYKKRWVVERTFAWLKRFRRLATRYEKLARNFLAFVHLACIRIWL 257
DDE_Tnp_1_2 pfam13586
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
 44-125 4.09e-07

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.


Pssm-ID: 463928 [Multi-domain]  Cd Length: 90  Bit Score: 45.10  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307925815  44 RAYERDSTRLPAESFGLTPVVPPKR----NRTAPWDYDREAHKGRNMVERVFNRMKHHRKAATRHDRLDETFLANLQLIP 119
Cdd:pfam13586   5 RGYRTRHNREWLKERGIRASGPPLGrpakNKAQEKKQAREDEIARNVIEGKFGWFKRRRSLAKRYEKLASTFEGAIALTF 84


                  ....*.
gi 1307925815 120 IAIYLK 125
Cdd:pfam13586  85 LVINLR 90
DDE_Tnp_1 pfam01609
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
 1-99 7.94e-03

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.


Pssm-ID: 376573 [Multi-domain]  Cd Length: 196  Bit Score: 34.91  E-value: 7.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307925815   1 MASDGES-TVVEIHLSPGDEHDAAHGRRSMAALGASVGAHPLMGRAYERDSTRLPAESFGLTPVVPPKRNRTAPWDYDRE 79
Cdd:pfam01609  40 IAVDTRTgLILAVVLTPGNVHDSKGLLQLLDELRRRKGRLVLADAGYGGKELLDKLEEKGVDYLIRLKKNAKLIDDKRRG 119

                          90       100
                  ....*....|....*....|
gi 1307925815  80 AHKGRNMVERVFNRMKHHRK 99
Cdd:pfam01609 120 RLRKHGKLKILTKVDKLKGR 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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