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Conserved domains on  [gi|1307891685|gb|AUD95942|]
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Conserved hypothetical secreted protein with presumed diacylglycerol kinase catalytic domain [Bifidobacterium breve]

Protein Classification

diacylglycerol/lipid kinase family protein( domain architecture ID 11446635)

diacylglycerol/lipid kinase family protein may catalyze the ATP-dependent phosphorylation of diacylglycerol and/or other lipids, and is involved in the phospholipid biosynthetic process

CATH:  3.40.50.10330
EC:  2.7.1.-
Gene Ontology:  GO:0008654|GO:0001727|GO:0005524|GO:0016310
SCOP:  3001940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 51-362 2.52e-70

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


:

Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 222.81  E-value: 2.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  51 YAFVVNPSKPQATARRL--HIQEFCKAKGLnRVRFYDTQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGH 128
Cdd:COG1597     5 ALLIVNPASGRGRAARLleRLVAALRAAGL-EVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTGP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 129 ALGIVPIGTGNLFARNMGIPVdDIDAALTVATSHGSRMVDMGRLTlldhpeddhGHAFLIIAGIGFDAAMIDDTDPDLKA 208
Cdd:COG1597    84 PLGILPLGTGNDFARALGIPL-DPEAALEALLTGRTRRIDLGRVN---------GRYFLNVAGIGFDAEVVERANRALKR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 209 NISWLAYFVGGVKNLFAPKFRgNLTVTsADGSTHTTNnlaFRTVMAGNCGQIP-VFSLMPAASYDDGILDFEIIdTTGGI 287
Cdd:COG1597   154 RLGKLAYVLAALRALLRYRPF-RLRIE-LDGEEIEGE---ALLVAVGNGPYYGgGLRLAPDASLDDGLLDVVVV-RPLSR 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1307891685 288 LGWANLFGDVVHQTIIGKPEqnplstnstIEQVQGLSAEIVLEKPAKAQVDGDMLPETKHIRFSVDHRALIVRVP 362
Cdd:COG1597   228 LRLLRLLPRLLRGRHLRHPG---------VRYFRAREVEIESDRPLPVQLDGEPLGLATPLEFEVLPGALRVLVP 293
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 51-362 2.52e-70

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 222.81  E-value: 2.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  51 YAFVVNPSKPQATARRL--HIQEFCKAKGLnRVRFYDTQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGH 128
Cdd:COG1597     5 ALLIVNPASGRGRAARLleRLVAALRAAGL-EVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTGP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 129 ALGIVPIGTGNLFARNMGIPVdDIDAALTVATSHGSRMVDMGRLTlldhpeddhGHAFLIIAGIGFDAAMIDDTDPDLKA 208
Cdd:COG1597    84 PLGILPLGTGNDFARALGIPL-DPEAALEALLTGRTRRIDLGRVN---------GRYFLNVAGIGFDAEVVERANRALKR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 209 NISWLAYFVGGVKNLFAPKFRgNLTVTsADGSTHTTNnlaFRTVMAGNCGQIP-VFSLMPAASYDDGILDFEIIdTTGGI 287
Cdd:COG1597   154 RLGKLAYVLAALRALLRYRPF-RLRIE-LDGEEIEGE---ALLVAVGNGPYYGgGLRLAPDASLDDGLLDVVVV-RPLSR 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1307891685 288 LGWANLFGDVVHQTIIGKPEqnplstnstIEQVQGLSAEIVLEKPAKAQVDGDMLPETKHIRFSVDHRALIVRVP 362
Cdd:COG1597   228 LRLLRLLPRLLRGRHLRHPG---------VRYFRAREVEIESDRPLPVQLDGEPLGLATPLEFEVLPGALRVLVP 293
PRK00861 PRK00861
putative lipid kinase; Reviewed
 84-362 1.45e-32

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 123.96  E-value: 1.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  84 YDTQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGHALGIVPIGTGNLFARNMGIPvDDIDAALTVATSHG 163
Cdd:PRK00861   38 YLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALIGTDIPLGIIPRGTANAFAAALGIP-DTIEEACRTILQGK 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 164 SRMVDMGRLtlldhpeddHGHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNLFAPKfrgNLTVT-SADGSTH 242
Cdd:PRK00861  117 TRRVDVAYC---------NGQPMILLAGIGFEAETVEEADREAKNRFGILAYILSGLQQLRELE---SFEVEiETEDQII 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 243 TTNNLAF--------RTVMAGNCGqipvfslmpAASYDDGILDFEIIDTTggilgwaNLFGDV---VH--QT-IIGKPEQ 308
Cdd:PRK00861  185 TTNAVAVtvanaappTSVLAQGPG---------AVIPDDGLLDVTIVAPK-------NLAEAVaasYHllQTaLQGNPAE 248

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1307891685 309 NPLSTNSTIEQVQglsaeIVLEKPAKAQVDGDMLPETKhIRFSVDHRALIVRVP 362
Cdd:PRK00861  249 RDDIGYLRAKQVK-----ITTDPPQKVVIDGEVVGTTP-IEIECLPRSLKVFAP 296
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 53-172 6.69e-28

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 106.52  E-value: 6.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  53 FVVNPSKPQATARRL--HIQEFCKAKGLnRVRFYDTQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGH-- 128
Cdd:pfam00781   4 VIVNPKSGGGKGKKLlrKVRPLLNKAGV-EVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLATrp 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1307891685 129 ALGIVPIGTGNLFARNMGIPVdDIDAALTVATSHGSRMVDMGRL 172
Cdd:pfam00781  83 PLGIIPLGTGNDFARALGIPG-DPEEALEAILKGQTRPVDVGKV 125
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 98-284 1.11e-17

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 82.55  E-value: 1.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  98 EALEDGADVVIAVGGDGTVRTVASAVSGTGH--ALGIVPIGTGNLFARNMGIPvDDIDAALTVATSHGSRMVDMGRLTLL 175
Cdd:TIGR00147  52 EARKFGVDTVIAGGGDGTINEVVNALIQLDDipALGILPLGTANDFARSLGIP-EDLDKAAKLVIAGDARAIDMGQVNKQ 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 176 dhpeddhgHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNL--FAPkFRGNLTVtsaDGSTHTTNNLAFrTVM 253
Cdd:TIGR00147 131 --------YCFINMAGGGFGTEITTETPEKLKAALGSLSYILSGLMRMdtLQP-FRCEIRG---EGEHWQGEAVVF-LVG 197

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1307891685 254 AGN---CGQIPvfslMPAASYDDGILDFEIIDTT 284
Cdd:TIGR00147 198 NGRqagGGQKL----APDASINDGLLDLRIFTND 227
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 69-148 9.76e-08

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 50.37  E-value: 9.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685   69 IQEFCKAkgLNRVRFYDTqlDKDGRDCALEALEDGAD--VVIAVGGDGTVRTVASAVS-----GTGHALGIVPIGTGNLF 141
Cdd:smart00046  17 LRKFRLL--LNPRQVFDL--TKKGPAVALVIFRDVPDfnRVLVCGGDGTVGWVLNALDkrelpLPEPPVAVLPLGTGNDL 92


                   ....*..
gi 1307891685  142 ARNMGIP 148
Cdd:smart00046  93 ARSLGWG 99
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 51-362 2.52e-70

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 222.81  E-value: 2.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  51 YAFVVNPSKPQATARRL--HIQEFCKAKGLnRVRFYDTQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGH 128
Cdd:COG1597     5 ALLIVNPASGRGRAARLleRLVAALRAAGL-EVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTGP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 129 ALGIVPIGTGNLFARNMGIPVdDIDAALTVATSHGSRMVDMGRLTlldhpeddhGHAFLIIAGIGFDAAMIDDTDPDLKA 208
Cdd:COG1597    84 PLGILPLGTGNDFARALGIPL-DPEAALEALLTGRTRRIDLGRVN---------GRYFLNVAGIGFDAEVVERANRALKR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 209 NISWLAYFVGGVKNLFAPKFRgNLTVTsADGSTHTTNnlaFRTVMAGNCGQIP-VFSLMPAASYDDGILDFEIIdTTGGI 287
Cdd:COG1597   154 RLGKLAYVLAALRALLRYRPF-RLRIE-LDGEEIEGE---ALLVAVGNGPYYGgGLRLAPDASLDDGLLDVVVV-RPLSR 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1307891685 288 LGWANLFGDVVHQTIIGKPEqnplstnstIEQVQGLSAEIVLEKPAKAQVDGDMLPETKHIRFSVDHRALIVRVP 362
Cdd:COG1597   228 LRLLRLLPRLLRGRHLRHPG---------VRYFRAREVEIESDRPLPVQLDGEPLGLATPLEFEVLPGALRVLVP 293
PRK00861 PRK00861
putative lipid kinase; Reviewed
 84-362 1.45e-32

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 123.96  E-value: 1.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  84 YDTQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGHALGIVPIGTGNLFARNMGIPvDDIDAALTVATSHG 163
Cdd:PRK00861   38 YLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALIGTDIPLGIIPRGTANAFAAALGIP-DTIEEACRTILQGK 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 164 SRMVDMGRLtlldhpeddHGHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNLFAPKfrgNLTVT-SADGSTH 242
Cdd:PRK00861  117 TRRVDVAYC---------NGQPMILLAGIGFEAETVEEADREAKNRFGILAYILSGLQQLRELE---SFEVEiETEDQII 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 243 TTNNLAF--------RTVMAGNCGqipvfslmpAASYDDGILDFEIIDTTggilgwaNLFGDV---VH--QT-IIGKPEQ 308
Cdd:PRK00861  185 TTNAVAVtvanaappTSVLAQGPG---------AVIPDDGLLDVTIVAPK-------NLAEAVaasYHllQTaLQGNPAE 248

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1307891685 309 NPLSTNSTIEQVQglsaeIVLEKPAKAQVDGDMLPETKhIRFSVDHRALIVRVP 362
Cdd:PRK00861  249 RDDIGYLRAKQVK-----ITTDPPQKVVIDGEVVGTTP-IEIECLPRSLKVFAP 296
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 53-172 6.69e-28

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 106.52  E-value: 6.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  53 FVVNPSKPQATARRL--HIQEFCKAKGLnRVRFYDTQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGH-- 128
Cdd:pfam00781   4 VIVNPKSGGGKGKKLlrKVRPLLNKAGV-EVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLATrp 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1307891685 129 ALGIVPIGTGNLFARNMGIPVdDIDAALTVATSHGSRMVDMGRL 172
Cdd:pfam00781  83 PLGIIPLGTGNDFARALGIPG-DPEEALEAILKGQTRPVDVGKV 125
PRK13054 PRK13054
lipid kinase; Reviewed
 98-367 2.55e-22

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 96.10  E-value: 2.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  98 EALEDGADVVIAVGGDGTVRTVASAVSGTGH----ALGIVPIGTGNLFARNMGIPvDDIDAALTVATSHGSRMVDMGRLt 173
Cdd:PRK13054   51 EALALGVATVIAGGGDGTINEVATALAQLEGdarpALGILPLGTANDFATAAGIP-LEPDKALKLAIEGRAQPIDLARV- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 174 lldhpeDDHgHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNLfapkfrgnLTVTSADGSTHT---TNNLAFR 250
Cdd:PRK13054  129 ------NDR-TYFINMATGGFGTRVTTETPEKLKAALGGVAYLIHGLMRM--------DTLKPDRCEIRGpdfHWQGDAL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 251 TVMAGNC-----GQIpvfsLMPAASYDDGILDFEIIDTTGGILGwanlfgdVVHQTIIGKPEQNPLSTNSTIEQVqglsa 325
Cdd:PRK13054  194 VIGIGNGrqaggGQQ----LCPEALINDGLLDLRILPAPQELLP-------TLLSTLTGGSEDNPNIIRARLPWL----- 257

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1307891685 326 EIVLEKPAKAQVDGDMLpETKHIRFSVDHRALIVRVPDTSAL 367
Cdd:PRK13054  258 EIQAPHELTFNLDGEPL-SGRHFRIEVLPAALRCRLPPDCPL 298
PRK13057 PRK13057
lipid kinase;
91-278 2.94e-20

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 89.98  E-value: 2.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  91 DGRDCA--LEALEDGADVVIAVGGDGTVRTVASAVSGTGHALGIVPIGTGNLFARNMGIPVDDIDAALTVATSHgSRMVD 168
Cdd:PRK13057   36 DPDDLSevIEAYADGVDLVIVGGGDGTLNAAAPALVETGLPLGILPLGTANDLARTLGIPLDLEAAARVIATGQ-VRRID 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 169 MGRLtlldhpeddHGHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNLF-APKFRGNLtvtSADGSThttnnL 247
Cdd:PRK13057  115 LGWV---------NGHYFFNVASLGLSAELARRLTKELKRRWGTLGYAIAALRVLRrSRPFTAEI---EHDGRT-----E 177

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1307891685 248 AFRTVMA--GN----CGQIPVFslmPAASYDDGILDF 278
Cdd:PRK13057  178 RVKTLQVavGNgryyGGGMTVA---HDATIDDGRLDL 211
PRK12361 PRK12361
hypothetical protein; Provisional
 86-365 3.38e-19

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 89.29  E-value: 3.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  86 TQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGHALGIVPIGTGN-----LF-ARNMGIPVDdiDAALTVA 159
Cdd:PRK12361  280 TTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELVNTDITLGIIPLGTANalshaLFgLGSKLIPVE--QACDNII 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 160 TSHgSRMVDMGRLtlldhpeddHGHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYfVGGVKNLFAPKFRGNLTVTSADG 239
Cdd:PRK12361  358 QGH-TQRIDTARC---------NDRLMLLLVGIGFEQKMIESADRERKNALGQLAY-LDGLWRAVNENETLTLTVTLDDA 426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 240 -----STHT---TNNLAFRTVMAGNCGQiPVfslmpaasYDDGILDFEIIDTTGGILGWANLFGDVVHQTIIGKPEqnpl 311
Cdd:PRK12361  427 epqtiSTHSlvvANAAPFTSLLAQGGGE-PN--------MTDGLLDITWLDSGGEPGEQLLSLAELALSGLGKEPE---- 493

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1307891685 312 stNSTIEQVQGLSAEIVLEKPAKAQVDGDmLPETKHIRFSVDHRALIVRVPDTS 365
Cdd:PRK12361  494 --ANKVHHAHAKKVTISSQKPIKYVIDGE-LFEDEDLTIEVQPASLKVFVPYQE 544
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 98-284 1.11e-17

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 82.55  E-value: 1.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  98 EALEDGADVVIAVGGDGTVRTVASAVSGTGH--ALGIVPIGTGNLFARNMGIPvDDIDAALTVATSHGSRMVDMGRLTLL 175
Cdd:TIGR00147  52 EARKFGVDTVIAGGGDGTINEVVNALIQLDDipALGILPLGTANDFARSLGIP-EDLDKAAKLVIAGDARAIDMGQVNKQ 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 176 dhpeddhgHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNL--FAPkFRGNLTVtsaDGSTHTTNNLAFrTVM 253
Cdd:TIGR00147 131 --------YCFINMAGGGFGTEITTETPEKLKAALGSLSYILSGLMRMdtLQP-FRCEIRG---EGEHWQGEAVVF-LVG 197

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1307891685 254 AGN---CGQIPvfslMPAASYDDGILDFEIIDTT 284
Cdd:TIGR00147 198 NGRqagGGQKL----APDASINDGLLDLRIFTND 227
PRK13337 PRK13337
putative lipid kinase; Reviewed
 84-284 7.80e-17

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 80.48  E-value: 7.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  84 YDTQLDKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGH--ALGIVPIGTGNLFARNMGIPVDDIDAALTVATS 161
Cdd:PRK13337   38 HATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEKENrpKLGIIPVGTTNDFARALHVPRDIEKAADVIIEG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 162 HgSRMVDMGRLTlldhpeddhGHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNLfaPKFRGNLTVTSADGST 241
Cdd:PRK13337  118 H-TVPVDIGKAN---------NRYFINIAGGGRLTELTYEVPSKLKTMLGQLAYYLKGIEML--PSLKATDVRIEYDGKL 185

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1307891685 242 HTTNNLAFrtvMAGNCGQIPVFS-LMPAASYDDGILDFEIIDTT 284
Cdd:PRK13337  186 FQGEIMLF---LLGLTNSVGGFEkLAPDASLDDGYFDLIIVKKA 226
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 91-203 8.67e-15

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 74.44  E-value: 8.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  91 DGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGHALGIVPIGTGNLFARNMGIPVDDIDAALTVATSHGSRMVDMG 170
Cdd:PRK11914   52 DARHLVAAALAKGTDALVVVGGDGVISNALQVLAGTDIPLGIIPAGTGNDHAREFGIPTGDPEAAADVIVDGWTETVDLG 131

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1307891685 171 RLTLldhpeDDHGHA-FLIIAGIGFDAAMIDDTD 203
Cdd:PRK11914  132 RIQD-----DDGIVKwFGTVAATGFDSLVTDRAN 160
PRK13059 PRK13059
putative lipid kinase; Reviewed
 89-281 2.19e-14

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 73.15  E-value: 2.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  89 DKDGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGHAL--GIVPIGTGNLFARNMGIPvDDIDAALTVATSHGSRM 166
Cdd:PRK13059   42 LEYDLKNAFKDIDESYKYILIAGGDGTVDNVVNAMKKLNIDLpiGILPVGTANDFAKFLGMP-TDIGEACEQILKSKPKK 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 167 VDMGRLtlldhpeDDhgHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNLfaPKFRG-NLTVTSA----DGST 241
Cdd:PRK13059  121 VDLGKI-------ND--KYFINVASTGLFTDVSQKTDVNLKNTIGKLAYYLKGLEEL--PNFRKlKVKVTSEevnfDGDM 189

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1307891685 242 HTTnnLAFRTVMAGNcgqipvFSLMPAASYDDGILDFEII 281
Cdd:PRK13059  190 YLM--LVFNGQTAGN------FNLAYKAEVDDGLLDVIII 221
PRK13055 PRK13055
putative lipid kinase; Reviewed
 93-294 1.48e-11

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 65.01  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  93 RDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGH--ALGIVPIGTGNLFARNMGIPVDDIDAALTVATSHGSRMVDMG 170
Cdd:PRK13055   49 KNEAKRAAEAGFDLIIAAGGDGTINEVVNGIAPLEKrpKMAIIPAGTTNDYARALKIPRDNPVEAAKVILKNQTIKMDIG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685 171 RLtlldhpedDHGHAFLIIAGIGFDAAMIDDTDPDLKANISWLAYFVGGVKNLfaPKFRGNLTVTSADGSTHTTNNLAFR 250
Cdd:PRK13055  129 RA--------NEDKYFINIAAGGSLTELTYSVPSQLKSMFGYLAYLAKGAELL--PRVSPVPVRITYDEGVFEGKISMFF 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1307891685 251 TVMAGNCGQIPvfSLMPAASYDDGIldFEIIdttggILGWANLF 294
Cdd:PRK13055  199 LALTNSVGGFE--QIVPDAKLDDGK--FTLI-----IVKTANLF 233
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 69-148 9.76e-08

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 50.37  E-value: 9.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685   69 IQEFCKAkgLNRVRFYDTqlDKDGRDCALEALEDGAD--VVIAVGGDGTVRTVASAVS-----GTGHALGIVPIGTGNLF 141
Cdd:smart00046  17 LRKFRLL--LNPRQVFDL--TKKGPAVALVIFRDVPDfnRVLVCGGDGTVGWVLNALDkrelpLPEPPVAVLPLGTGNDL 92


                   ....*..
gi 1307891685  142 ARNMGIP 148
Cdd:smart00046  93 ARSLGWG 99
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
52-156 9.36e-07

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 49.75  E-value: 9.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  52 AFVVNPSKPQATARRLHIQEFCKAKGLNRVRFYDTQLDKdgrdCALEALEDGADVVIAVGGDGTVRTVASAVSGTGhaLG 131
Cdd:COG0061     5 AIVAKPGKPEALEAAEELAELLEERGIEVVLDEDTAVPG----VPLEELGEEADLVIVLGGDGTLLRAARLLAPLG--IP 78

                          90       100
                  ....*....|....*....|....*....
gi 1307891685 132 IVPIGTGNLfarnmG----IPVDDIDAAL 156
Cdd:COG0061    79 ILGINLGRL-----GflteIEPEELEEAL 102
NAD_kinase pfam01513
ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 33-140 1.27e-04

ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.


Pssm-ID: 426300 [Multi-domain]  Cd Length: 128  Bit Score: 41.58  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307891685  33 RRRKLAETLEKRRddevqyAFVVNPSKPQATARRLHIQEFCKAKGLNRVRFYDTQLDkdgrdcALEALEDGADVVIAVGG 112
Cdd:pfam01513  15 RAREVARWLLDRL------GITVTVEEKMGESLAFAAGDRPEVIGCLKKVVDDTRRA------TRAFADAGVDLIIVLGG 82

                          90       100
                  ....*....|....*....|....*...
gi 1307891685 113 DGTVRTVASAVsgTGHALGIVPIGTGNL 140
Cdd:pfam01513  83 DGTALRAARLL--QKAVIPILGVNTGVL 108
COG3199 COG3199
NAD kinase [Nucleotide transport and metabolism];
91-137 7.80e-04

NAD kinase [Nucleotide transport and metabolism];


Pssm-ID: 442432 [Multi-domain]  Cd Length: 367  Bit Score: 41.41  E-value: 7.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1307891685  91 DGRDCALEALEDGADVVIAVGGDGTVRTVASAVSGTGHALGIvPIGT 137
Cdd:COG3199    93 DTRRAARAMLEAGVDLIVFLGGDGTARDVAKAVGDSVPVLGI-PAGV 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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