NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1304837040|gb|AUD53795|]
View 

zinc fingers and homeoboxes 2, partial [Phrynomantis microps]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
zf_C2H2_ZHX super family cl39725
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 1-40 2.62e-13

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


The actual alignment was detected with superfamily member pfam18387:

Pssm-ID: 465737  Cd Length: 53  Bit Score: 63.89  E-value: 2.62e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1304837040   1 TTKKYDCLSDHNSKLHPGESNFKLKLMKRNNQTILEQSIE 40
Cdd:pfam18387  13 LAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLV 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 140-189 6.09e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.08  E-value: 6.09e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1304837040 140 DTNATLISSFNKFPYPTQAELSWLTAASKHPEEQIRIWFATQRLKHGISW 189
Cdd:cd00086    10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 306-346 7.41e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 37.22  E-value: 7.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1304837040 306 RYERRKNHEQIAHLKASFVMSHFPDDAEIYRLIDITGLSRS 346
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTER 42
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 1-40 2.62e-13

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 63.89  E-value: 2.62e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1304837040   1 TTKKYDCLSDHNSKLHPGESNFKLKLMKRNNQTILEQSIE 40
Cdd:pfam18387  13 LAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLV 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 140-189 6.09e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.08  E-value: 6.09e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1304837040 140 DTNATLISSFNKFPYPTQAELSWLTAASKHPEEQIRIWFATQRLKHGISW 189
Cdd:cd00086    10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 143-185 8.56e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 45.32  E-value: 8.56e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1304837040  143 ATLISSFNKFPYPTQAELSWLTAASKHPEEQIRIWFATQRLKH 185
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 306-346 7.41e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 37.22  E-value: 7.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1304837040 306 RYERRKNHEQIAHLKASFVMSHFPDDAEIYRLIDITGLSRS 346
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTER 42
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 306-346 9.83e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 36.84  E-value: 9.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1304837040  306 RYERRKNHEQIAHLKASFVMSHFPDDAEIYRLIDITGLSRS 346
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSER 43
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 1-40 2.62e-13

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 63.89  E-value: 2.62e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1304837040   1 TTKKYDCLSDHNSKLHPGESNFKLKLMKRNNQTILEQSIE 40
Cdd:pfam18387  13 LAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLV 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 140-189 6.09e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.08  E-value: 6.09e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1304837040 140 DTNATLISSFNKFPYPTQAELSWLTAASKHPEEQIRIWFATQRLKHGISW 189
Cdd:cd00086    10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 143-185 8.56e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 45.32  E-value: 8.56e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1304837040  143 ATLISSFNKFPYPTQAELSWLTAASKHPEEQIRIWFATQRLKH 185
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 306-346 7.41e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 37.22  E-value: 7.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1304837040 306 RYERRKNHEQIAHLKASFVMSHFPDDAEIYRLIDITGLSRS 346
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTER 42
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 306-346 9.83e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 36.84  E-value: 9.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1304837040  306 RYERRKNHEQIAHLKASFVMSHFPDDAEIYRLIDITGLSRS 346
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSER 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH