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Conserved domains on  [gi|1304137069|gb|AUC99148|]
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PQQ-dependent dehydrogenase, methanol/ethanol family [Bradyrhizobium sp. SK17]

Protein Classification

methanol/ethanol family PQQ-dependent dehydrogenase( domain architecture ID 10178893)

methanol/ethanol family PQQ-dependent dehydrogenase similar to Thauera butanivorans 1-butanol dehydrogenase (quinone) that catalyzes the oxidation of 1-butanol to 1-butanal and may function primarily in energy generation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 36-573 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


:

Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 796.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  36 ARLENPEPGNWMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVL-EGHEAPPIVNNGVMFVATPMGQVIALNAKTG 114
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGKqRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 115 EEYWRYKRQLPDDLF-QLHPTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVG 193
Cdd:cd10277    81 KELWKYKHRLPEDIRpCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 194 GSGGEFGVRGYVVAFDAGSGKELWRTFTIPGEGEPGHE-TWSGDDWKSGGGAAWMTGTYDKDTKTVYWGIGNASPWPGSM 272
Cdd:cd10277   161 VSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTdTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAPWNGDL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 273 HPGDNLYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIHPGRDAIFWVLERKPdkINYVAG 352
Cdd:cd10277   241 RPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLDRTN--GKLIWA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 353 WPFVKTNVWKGIEAETGRPILDPDH-KPVLGKRVEFCPSLWGGKDWPSAAYSPNTKLVYVPANEnFCGGFTGEKQPLVPG 431
Cdd:cd10277   319 TPFVKKITWASIDLKTGRPIYDEDKvPPKKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANH-WCMDLTGEPVSYKKG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 432 QLWLGTKPEDIGLFPapnaDHFGELQAWDPATGKKVWQHDYKtSQLFGSVTATAGDLVLAGGTnDRAFRIFNAKTGELLW 511
Cdd:cd10277   398 AAYLGAGFTIKPPFE----DHIGELQAIDPTTGKKVWEHKTP-LPLWGGVLTTAGGLVFTGTP-DGYFRAFDAKTGKELW 471

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1304137069 512 EQKTNSGIMAMPMSYEVDGTQYIAVQSGWGVDAQRIQdalaGKVAGFENNVPQGGVIWVFAL 573
Cdd:cd10277   472 EFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWG----GDMAKLLKNVPQGGSLWVFAL 529
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 36-573 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 796.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  36 ARLENPEPGNWMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVL-EGHEAPPIVNNGVMFVATPMGQVIALNAKTG 114
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGKqRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 115 EEYWRYKRQLPDDLF-QLHPTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVG 193
Cdd:cd10277    81 KELWKYKHRLPEDIRpCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 194 GSGGEFGVRGYVVAFDAGSGKELWRTFTIPGEGEPGHE-TWSGDDWKSGGGAAWMTGTYDKDTKTVYWGIGNASPWPGSM 272
Cdd:cd10277   161 VSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTdTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAPWNGDL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 273 HPGDNLYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIHPGRDAIFWVLERKPdkINYVAG 352
Cdd:cd10277   241 RPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLDRTN--GKLIWA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 353 WPFVKTNVWKGIEAETGRPILDPDH-KPVLGKRVEFCPSLWGGKDWPSAAYSPNTKLVYVPANEnFCGGFTGEKQPLVPG 431
Cdd:cd10277   319 TPFVKKITWASIDLKTGRPIYDEDKvPPKKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANH-WCMDLTGEPVSYKKG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 432 QLWLGTKPEDIGLFPapnaDHFGELQAWDPATGKKVWQHDYKtSQLFGSVTATAGDLVLAGGTnDRAFRIFNAKTGELLW 511
Cdd:cd10277   398 AAYLGAGFTIKPPFE----DHIGELQAIDPTTGKKVWEHKTP-LPLWGGVLTTAGGLVFTGTP-DGYFRAFDAKTGKELW 471

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1304137069 512 EQKTNSGIMAMPMSYEVDGTQYIAVQSGWGVDAQRIQdalaGKVAGFENNVPQGGVIWVFAL 573
Cdd:cd10277   472 EFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWG----GDMAKLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 28-541 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 703.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  28 DNYSPVTSARLEN--PEPGNWMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVLEGHEAPPIVNNGVMFVATPMGQ 105
Cdd:TIGR03075   1 AAAAAVTNEDLLNdaKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLGKQRGQESQPLVVDGVMYVTTSYSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 106 VIALNAKTGEEYWRYKRQLPDDLFQLHPT---SRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLM 182
Cdd:TIGR03075  81 VYALDAKTGKILWKYDPKLPDDIIPVMCCdvvNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 183 PLVVDGKVIVGGSGGEFGVRGYVVAFDAGSGKELWRTFTIPGE------------GEPGHETWSGDDWKSGGGAAWMTGT 250
Cdd:TIGR03075 161 PLVVKGKVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDmgylkktgkpvgGDPGAKTWPGDAWKTGGGATWGTGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 251 YDKDTKTVYWGIGNASPWPGSMHPGDNLYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIH 330
Cdd:TIGR03075 241 YDPETNLIYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLKKDGKPRKLLAH 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 331 PGRDAIFWVLERKPDKinYVAGWPFVKTNVW-KGIEAETGRPILDPDHKPVL---GKRVEFCPSLWGGKDWPSAAYSPNT 406
Cdd:TIGR03075 321 ADRNGFFYVLDRTNGK--LLSAEPFVDKVNWaTGVDLKTGRPIEVPEARSTDgkkGKPVEVCPGFLGGKNWQPMAYSPKT 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 407 KLVYVPANEnFCGGFTGEKQPLVPGQLWLGtkpedIGL-FPAPNADHFGELQAWDPATGKKVWQHDYKTSqLFGSVTATA 485
Cdd:TIGR03075 399 GLFYVPANH-VCMDYWPEKVSYKKGAAYLG-----AGFtIKPPPDDHIGSLIAWDPITGKIVWEHKEDFP-LWGGVLATA 471

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1304137069 486 GDLVLAgGTNDRAFRIFNAKTGELLWEQKTNSGIMAMPMSYEVDGTQYIAVQSGWG 541
Cdd:TIGR03075 472 GDLVFT-GTLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWG 526
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
42-573 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 640.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  42 EPGNWMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVLE--GHEAPPIVNNGVMFVATPMGQVIALNAKTGEEYWR 119
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPerGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 120 YKRQLPDDLFQLHPTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEF 199
Cdd:COG4993    81 YDPKLPDDAACCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 200 GVRGYVVAFDAGSGKELWRTFTIPGEGEPGHETWS-GDDWKSGGGAAWMTGTYDKDTKTVYWGIGNASP-WPGSMHPGDN 277
Cdd:COG4993   161 GPRGVVRAYDARTGKLVWRFDTIPDPGEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPAPdWNGGQRPGDN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 278 LYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIHPGRDAIFWVLER---KPdkinyVAGWP 354
Cdd:COG4993   241 LYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTRKALVQATKNGFIYVLDRetgEP-----LVTQP 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 355 FVKT-NVWKGIEAETGRPILDPDHKpvLGKRVEFCPSLWGGKDWPSAAYSPNTKLVYVPANENfCGGFTGEKQPLVPGQL 433
Cdd:COG4993   316 FVKPpNWATEIDMWGATPIQTPPSL--DGKTTLICPGALGGKNWGPAAYDPETGLLYVPANEL-CMDYELVPREYQAGAP 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 434 WLGTkpeDIGLFPAPnADHFGELQAWDPATGKKVWQHDYKTSqLFGSVTATAGDLVLAgGTNDRAFRIFNAKTGELLWEQ 513
Cdd:COG4993   393 YLGA---TLTMYPCP-APPWGTLTAIDLNTGKIVWQVPLGFP-NWGGPLATAGGLVFI-GTLDGYLRAFDAKTGKELWKF 466

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 514 KTNSGIMAMPMSYEVDGTQYIAVQSGWGVdaqriqdalagkVAGFENNVPQGGVIWVFAL 573
Cdd:COG4993   467 RLPSGGQATPMTYEVDGKQYVAVAAGGGG------------WLGLGLYTPQGDYLIAFAL 514
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 73-293 4.06e-16

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 77.83  E-value: 4.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  73 KPVWTFSTGVLEGHEAPpiVNNGVMFVATPMGQVIALNAKTGEEYWRYKrqlpddlfqlhPTSRGVG---LWEDKLYLAT 149
Cdd:pfam13360  14 AELWRVDLETGLGGGVA--VDGGRLFVATGGGQLVALDAATGKLLWRQT-----------LSGEVLGaplVAGGRVFVVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 150 TDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEfgvrgyVVAFDAGSGKELW-RTFTIPGEGEP 228
Cdd:pfam13360  81 GDGSLIALDAADGRRLWSYQRSGEPLALRSSGSPAVVGDTVVAGFSSGK------LVALDPATGKVRWeAPLAAPRGTNE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1304137069 229 GHET---------WSGDDWKSGGGAAwmTGTYDKDTKTVYWGIGNASPwPGSMHPGDNLYTSS----VLALDPDSGKI 293
Cdd:pfam13360 155 LERLvditgtpvvAGGRVFASAYQGR--LVAFDAATGRRLWTREISGP-NGPILDGDLLYVVSddgeLYALDRATGAV 229
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 58-246 2.64e-15

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 78.05  E-value: 2.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  58 FSPLDQINtsNVKDLKPVWTFSTGVLEGH---EAPPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKRQLPDDLFQLHPT 134
Cdd:PRK11138   32 MSPLPQVE--NQFTPTTVWSTSVGDGVGDyysRLHPAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFSKNKS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 135 SR---GVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVqdykKGQYMTlMPLVVDGKVIVGGSggefgvRGYVVAFDAG 211
Cdd:PRK11138  110 ALlsgGVTVAGGKVYIGSEKGQVYALNAEDGEVAWQTKV----AGEALS-RPVVSDGLVLVHTS------NGMLQALNES 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1304137069 212 SGKELWR------TFTIPGEGEP----GHETWSGDDWK------SGGGAAW 246
Cdd:PRK11138  179 DGAVKWTvnldvpSLTLRGESAPatafGGAIVGGDNGRvsavlmEQGQLIW 229
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 89-121 1.36e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 39.05  E-value: 1.36e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1304137069   89 PPIVNNGVMFVATPMGQVIALNAKTGEEYWRYK 121
Cdd:smart00564   1 PVVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 36-573 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 796.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  36 ARLENPEPGNWMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVL-EGHEAPPIVNNGVMFVATPMGQVIALNAKTG 114
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGKqRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 115 EEYWRYKRQLPDDLF-QLHPTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVG 193
Cdd:cd10277    81 KELWKYKHRLPEDIRpCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 194 GSGGEFGVRGYVVAFDAGSGKELWRTFTIPGEGEPGHE-TWSGDDWKSGGGAAWMTGTYDKDTKTVYWGIGNASPWPGSM 272
Cdd:cd10277   161 VSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTdTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAPWNGDL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 273 HPGDNLYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIHPGRDAIFWVLERKPdkINYVAG 352
Cdd:cd10277   241 RPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLDRTN--GKLIWA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 353 WPFVKTNVWKGIEAETGRPILDPDH-KPVLGKRVEFCPSLWGGKDWPSAAYSPNTKLVYVPANEnFCGGFTGEKQPLVPG 431
Cdd:cd10277   319 TPFVKKITWASIDLKTGRPIYDEDKvPPKKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANH-WCMDLTGEPVSYKKG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 432 QLWLGTKPEDIGLFPapnaDHFGELQAWDPATGKKVWQHDYKtSQLFGSVTATAGDLVLAGGTnDRAFRIFNAKTGELLW 511
Cdd:cd10277   398 AAYLGAGFTIKPPFE----DHIGELQAIDPTTGKKVWEHKTP-LPLWGGVLTTAGGLVFTGTP-DGYFRAFDAKTGKELW 471

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1304137069 512 EQKTNSGIMAMPMSYEVDGTQYIAVQSGWGVDAQRIQdalaGKVAGFENNVPQGGVIWVFAL 573
Cdd:cd10277   472 EFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWG----GDMAKLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 28-541 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 703.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  28 DNYSPVTSARLEN--PEPGNWMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVLEGHEAPPIVNNGVMFVATPMGQ 105
Cdd:TIGR03075   1 AAAAAVTNEDLLNdaKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLGKQRGQESQPLVVDGVMYVTTSYSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 106 VIALNAKTGEEYWRYKRQLPDDLFQLHPT---SRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLM 182
Cdd:TIGR03075  81 VYALDAKTGKILWKYDPKLPDDIIPVMCCdvvNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 183 PLVVDGKVIVGGSGGEFGVRGYVVAFDAGSGKELWRTFTIPGE------------GEPGHETWSGDDWKSGGGAAWMTGT 250
Cdd:TIGR03075 161 PLVVKGKVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDmgylkktgkpvgGDPGAKTWPGDAWKTGGGATWGTGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 251 YDKDTKTVYWGIGNASPWPGSMHPGDNLYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIH 330
Cdd:TIGR03075 241 YDPETNLIYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLKKDGKPRKLLAH 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 331 PGRDAIFWVLERKPDKinYVAGWPFVKTNVW-KGIEAETGRPILDPDHKPVL---GKRVEFCPSLWGGKDWPSAAYSPNT 406
Cdd:TIGR03075 321 ADRNGFFYVLDRTNGK--LLSAEPFVDKVNWaTGVDLKTGRPIEVPEARSTDgkkGKPVEVCPGFLGGKNWQPMAYSPKT 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 407 KLVYVPANEnFCGGFTGEKQPLVPGQLWLGtkpedIGL-FPAPNADHFGELQAWDPATGKKVWQHDYKTSqLFGSVTATA 485
Cdd:TIGR03075 399 GLFYVPANH-VCMDYWPEKVSYKKGAAYLG-----AGFtIKPPPDDHIGSLIAWDPITGKIVWEHKEDFP-LWGGVLATA 471

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1304137069 486 GDLVLAgGTNDRAFRIFNAKTGELLWEQKTNSGIMAMPMSYEVDGTQYIAVQSGWG 541
Cdd:TIGR03075 472 GDLVFT-GTLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWG 526
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
42-573 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 640.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  42 EPGNWMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVLE--GHEAPPIVNNGVMFVATPMGQVIALNAKTGEEYWR 119
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPerGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 120 YKRQLPDDLFQLHPTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEF 199
Cdd:COG4993    81 YDPKLPDDAACCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 200 GVRGYVVAFDAGSGKELWRTFTIPGEGEPGHETWS-GDDWKSGGGAAWMTGTYDKDTKTVYWGIGNASP-WPGSMHPGDN 277
Cdd:COG4993   161 GPRGVVRAYDARTGKLVWRFDTIPDPGEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPAPdWNGGQRPGDN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 278 LYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIHPGRDAIFWVLER---KPdkinyVAGWP 354
Cdd:COG4993   241 LYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTRKALVQATKNGFIYVLDRetgEP-----LVTQP 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 355 FVKT-NVWKGIEAETGRPILDPDHKpvLGKRVEFCPSLWGGKDWPSAAYSPNTKLVYVPANENfCGGFTGEKQPLVPGQL 433
Cdd:COG4993   316 FVKPpNWATEIDMWGATPIQTPPSL--DGKTTLICPGALGGKNWGPAAYDPETGLLYVPANEL-CMDYELVPREYQAGAP 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 434 WLGTkpeDIGLFPAPnADHFGELQAWDPATGKKVWQHDYKTSqLFGSVTATAGDLVLAgGTNDRAFRIFNAKTGELLWEQ 513
Cdd:COG4993   393 YLGA---TLTMYPCP-APPWGTLTAIDLNTGKIVWQVPLGFP-NWGGPLATAGGLVFI-GTLDGYLRAFDAKTGKELWKF 466

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 514 KTNSGIMAMPMSYEVDGTQYIAVQSGWGVdaqriqdalagkVAGFENNVPQGGVIWVFAL 573
Cdd:COG4993   467 RLPSGGQATPMTYEVDGKQYVAVAAGGGG------------WLGLGLYTPQGDYLIAFAL 514
PQQ_MDH cd10278
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ...
 46-573 2.81e-156

Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.


Pssm-ID: 199836 [Multi-domain]  Cd Length: 553  Bit Score: 458.71  E-value: 2.81e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  46 WMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVLEGHEAPPIVNNGVMFVATPM-GQVIALN-AKTGEEYWRYKRQ 123
Cdd:cd10278     1 WVMPGKDYANTRYSPLAQINKDNVKNLKVAWTFSTGVLRGHEGAPLVVGDTMYVVTPFpNNVYALDlNDPGKILWKYKPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 124 lPDDLFQ----LHPTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEF 199
Cdd:cd10278    81 -QDPSAVavacCDVVNRGLAYADGKIFFNQLDGHLVALDAKTGKEVWKVKNGDPKVGETLTMAPLVVKDKVIVGISGGEF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 200 GVRGYVVAFDAGSGKELWRTFTI------------------PGEGEPGHETWSGDDWKSGGGAAWMTGTYDKDTKTVYWG 261
Cdd:cd10278   160 GVRGYVTAYDLKTGKLVWRAYSTgpdkdvligpdfnpfnphDGGKDLGLSTWPGDAWKIGGGTNWGWYSYDPKLNLVYYG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 262 IGNASPWPGSMHPGDNLYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIHPGRDAIFWVLE 341
Cdd:cd10278   240 TGNPGPWNPTQRPGDNKWSMTIFARDPDTGEAKWAYQMTPHDEWDYDGVNEMILVDQTVDGKKRKLLVHFDRNGFVYTLD 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 342 RKPDkiNYVAGWPFVKTNVWKGIEAETGRPILDPDHKPVLGKRV-EFCPSLWGGKDWPSAAYSPNTKLVYVPANeNFCGG 420
Cdd:cd10278   320 RTTG--ELLSAEKFDPVNNWKGVDLKTGRPVKDPEKSTHMDHNVtDICPSAMGGKDQQPSSYSPKTGLFYVPTN-HLCMD 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 421 FTGEKQPLVPGQLWLGTkpeDIGLFPAPNAdHFGELQAWDPATGKKVWQHDYKTSqLFGSVTATAGDLVLAgGTNDRAFR 500
Cdd:cd10278   397 YEPFEVNYTAGQPYVGA---TLAMYPGPGG-HMGQFKAWDPVTGKTKWEIKERFP-VWSGTLATAGGLVFY-GTLDGWFK 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 501 IFNAKTGELLWEQKTNSGIMAMPMSYEVDGTQYIAVQSGWG--------VDAQRIQDAL--AGKVAGFENNVPQGGVIWV 570
Cdd:cd10278   471 AVDAKTGKLLWKFKLPSGIIGNPITYKHDGKQYVAVLSGVGgwagvgvaAGLRDPTAGLgaVGAFKDLPNYTQMGGTLYV 550


                  ...
gi 1304137069 571 FAL 573
Cdd:cd10278   551 FSL 553
PQQ_ADH_II cd10279
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ...
 44-541 1.08e-149

PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199837 [Multi-domain]  Cd Length: 549  Bit Score: 441.70  E-value: 1.08e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  44 GNWMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVLEGHEAPPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKRQ 123
Cdd:cd10279     1 GNWLSYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDTNRGQEATPLVVDGVMYVSGPWSVVYALDARTGKLLWQYDPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 124 LP---DDLFQLHPTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEFG 200
Cdd:cd10279    81 VDresGRKACCDVVNRGVAVWDGKVFVGTLDGRLIALDAKTGKEVWSVDTIDPRKPYTITGAPRVAKGKVVIGNGGAEFG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 201 VRGYVVAFDAGSGKELWRTFTIPGEGEPGHE----------TWSGDDWKSG-GGAAWMTGTYDKDTKTVYWGIGNASPWP 269
Cdd:cd10279   161 VRGYVSAYDAETGKLVWRFYTVPGNPAKPFEhasleaaaatWWTGEWWRTGgGGTVWDSITYDPELDLLYIGTGNGSPWN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 270 ---GSMHPGDNLYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIHPGRDAIFWVLERKPDK 346
Cdd:cd10279   241 rkvRSPGGGDNLFLSSIVALDADTGRYKWHYQTTPGDTWDYTATQPIILADLEIDGKPRKVLMHAPKNGFFYVLDRATGK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 347 inYVAGWPFVKTNVWKGIEAETGRPILDPDHKPVLGKRVEFcPSLWGGKDWPSAAYSPNTKLVYVPANENfcgGFTGEKQ 426
Cdd:cd10279   321 --LLSAEPFVPVNWATGIDLKTGRPIENPEARYTKGPKLVF-PGPLGAHNWHPMSYNPDTGLVYIPAQEI---PAVYEDD 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 427 PLVPGQL---W-----LGTKPEDIGLFPAPNADHFGELQAWDPATGKKVWQHDYKtSQLFGSVTATAGDLVLAgGTNDRA 498
Cdd:cd10279   395 PGDFGYNplgWntgitPDATPPPAAAKRALRKATRGRLVAWDPVTQKAAWRVEHP-GPWNGGVLATAGNLVFQ-GTADGE 472

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1304137069 499 FRIFNAKTGELLWEQKTNSGIMAMPMSYEVDGTQYIAVQSGWG 541
Cdd:cd10279   473 LAAYDARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAGWG 515
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 68-572 6.32e-108

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 330.72  E-value: 6.32e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  68 NVKDLKPVWTFSTGV--LEGHEAPPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKRQLPDDLFQ--LHPTSRGVGLWED 143
Cdd:cd00216     3 NVFQLTPAWSFSTGDggNRGSELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGWFEacCDLVNRGVAVWGG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 144 KLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEFGVRGYVVAFDAGSGKELWRTFTIP 223
Cdd:cd00216    83 KVYIGVLDGRVYALNAETGKVAWKVKNADVLGGYTATSAPVVVDGLVIIGSSGDEFGVRGYLTAYDVATGEEKWRFYLVM 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 224 G-----------EGEPGHETWSGDDWKSGGGAAWMTGTYDKDTKTVYWGIGNASPW--PGSMHPGDNLYTSSVLALDPDS 290
Cdd:cd00216   163 PdpnllpgkdstVTDRNTPTGDEHTWTSGGGTGWSSAAYDAELNLIYVGGGNPTPWnwGGNRTPGDNLYTSSIVAVNADT 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 291 GKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIHPGRDAIFWVLERKPDKInyvagwpfvktnVWKgieaetgR 370
Cdd:cd00216   243 GEMKWQYQTTPHDAWDYDGDNTPVLADIKVKGKKVKVLFAPAKNGNFYVLDRRNGEL------------VSA-------R 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 371 PiLDPDhkpvlgkrvefcpslwggkdwpsaAYSPNTKLVYVPANenfcggftgekqplvpgqlwlgtkpediglfpapna 450
Cdd:cd00216   304 P-LVPD------------------------SYDPDRELFYVPAN------------------------------------ 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 451 dhfGELQAWDPATGKKVWQHDYKTSqLFGSVTATAGDLVLAgGTNDRAFRIFNAKTGELLWEQKTNSGIMAMPMSYEVDG 530
Cdd:cd00216   323 ---GRIMALDPVTGVVVWEKSELHP-LLGGPLSTAGNLVFV-GTSDGYLKAYNADTGEKLWQQKVPSGFQAEPVTYEVDG 397

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1304137069 531 TQYIAVQSGWGVDAqriqdALAGKVAGFENNVPQGGVIWVFA 572
Cdd:cd00216   398 EQYVLIQAGGGGAF-----PLWGGMADLTRGTQMGGTVVVYK 434
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 46-539 5.71e-98

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 310.66  E-value: 5.71e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  46 WMLYRRTYDGQGFSPLDQINTSNVKDLKPVWTFSTGVLEGH-------EAPPIVNNGVMFVATPMGQVIALNAKTGEEYW 118
Cdd:cd10280     1 WPAYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDLPGPdgnegtfEATPLKVGGTLYLCTPHNRVIALDAATGKELW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 119 RYKRQLPDDLFQLHPTSRGVGLWEDK---------LYLATTDDHVVALDAKTGKVLWD----------TKVQDYKKGQY- 178
Cdd:cd10280    81 RFDPKAGADAAPGHQTCRGVSYWEDGaaaaacarrIFFGTGDARLIALDARTGKPCPDfgdngvvdlrEGLGRVKPGFYs 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 179 MTLMPLVVDGKVIVGGSGGEF----GVRGYVVAFDAGSGKELWrTF-TIPGEGEPGHETwsGDDWKSGGGA-AWMTGTYD 252
Cdd:cd10280   161 STSPPTVYGDLVIVGSAVADNqavdAPSGVIRAFDVRTGKLVW-AFdTIPPPGEAGPDT--AGAWYTRGGPnVWAGMSAD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 253 KDTKTVYWGIGNASP--WpGSMHPGDNLYTSSVLALDPDSGKIKTHFQYHQNDSWDWDEVDAPMLIDLQREGRSFKSLIH 330
Cdd:cd10280   238 EKLGLVYLPTGSATPdfY-GGDRPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQPTLVDVPRDGKTVPAVAQ 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 331 PGRDAIFWVLER---KPdkinyvaGWPFVKTNVWKG-IEAE---------TGRPILDP--------------DHK----- 378
Cdd:cd10280   317 PTKQGFVFVLDRrtgKP-------LWPVEERPVPQGdVPGErtsptqpfpTLPPPFARqglteddmwgatpfDQLacriq 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 379 ------------PVLGKRVEFcPSLWGGKDWPSAAYSPNTKLVYVPANE----------------NFCGGFTGEKQPLVP 430
Cdd:cd10280   390 frslryeglftpPSLDGTLIF-PGNDGGANWGGAAVDPERGILYVNSNRlpfviqlvprapgdpaGVAGGGEGGGGGGGP 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 431 GQLWLGTKPEDIGLFPAP-----NADHFGELQAWDPATGKKVWQHDYKTSQ-----------------LFGSVTaTAGDL 488
Cdd:cd10280   469 SPQAGTPYGVGRGRFLSPlglpcQAPPWGTLTAIDLNTGKILWQVPLGTVPdlgpkgiplpiptgtpnLGGPVV-TAGGL 547

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1304137069 489 VLAGGTNDRAFRIFNAKTGELLWEQKTNSGIMAMPMSYEVDGTQYIAVQSG 539
Cdd:cd10280   548 VFIAATQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAG 598
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 59-218 4.54e-20

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 92.18  E-value: 4.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  59 SPLDQINtsNVKDLKPVWTFSTGVLEGHEA---PPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKrqLPDDLfqlhptS 135
Cdd:COG1520    21 APLPEFE--PSVKVKQLWSASVGDGVGKGYsrlAPAVAGDRVYAADADGRVAALDAATGKELWRVD--LGEPL------S 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 136 RGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVqdykKGQYMTlMPLVVDGKVIVGGSGGEfgvrgyVVAFDAGSGKE 215
Cdd:COG1520    91 GGVGADGGLVVVGTEDGEVIALDADDGEELWRARL----SSEVLA-APAVAGGRVVVRTGDGR------VYALDAATGER 159


                  ...
gi 1304137069 216 LWR 218
Cdd:COG1520   160 LWS 162
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 54-295 6.59e-20

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 91.62  E-value: 6.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  54 DGQGFSPLDQINTSNVKDLkpvwtfSTGVLEGHEAPPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKrqLPDDLFQlhp 133
Cdd:cd10276     4 DLPEPTPEFDPEVLWSKSV------GNGGMAGIDLTPVVAGDMVYAADANGQVSAFNATTGKIIWETS--LSGKGFL--- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 134 tSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDykkGQYMTlMPLVVDGKVIVGGSGGEfgvrgyVVAFDAGSG 213
Cdd:cd10276    73 -GGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSD---SQLLS-PPTYADGKIYVGTGDGR------LYYCNAETG 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 214 KELW-RTFTIPGEGEPGHETWSGDDWKSGGGAAWMTGTY-DKDTKTVYWGIGNASPWPGSMHPG----------DNLYTS 281
Cdd:cd10276   142 KVVWnRTSTAPELSLRGGAAPVGAYDVVFVGDGNGTVVAlNTGTGVDIWEFSVSEPRGRTELPRmidssvtyvvVGGYLY 221

                         250       260
                  ....*....|....*....|
gi 1304137069 282 SV------LALDPDSGKIKT 295
Cdd:cd10276   222 STsyqgylVALDFESGQFLW 241
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 75-217 2.36e-16

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 81.13  E-value: 2.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  75 VWtfSTGVLEGHEAP-----PIVNNGVMFVATPMGQVIALNAKTGEEYWRykRQLPDDLfqlhptSRGVGLWEDKLYLAT 149
Cdd:TIGR03300  43 VW--SASVGDGVGHYylrlqPAVAGGKVYAADADGTVAALDAETGKRLWR--VDLDERL------SGGVGADGGLVFVGT 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1304137069 150 TDDHVVALDAKTGKVLWDTKVQdykkGQYMTlMPLVVDGKVIVGGSggefgvRGYVVAFDAGSGKELW 217
Cdd:TIGR03300 113 EKGEVIALDAEDGKELWRAKLS----SEVLS-PPLVANGLVVVRTN------DGRLTALDAATGERLW 169
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 73-293 4.06e-16

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 77.83  E-value: 4.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  73 KPVWTFSTGVLEGHEAPpiVNNGVMFVATPMGQVIALNAKTGEEYWRYKrqlpddlfqlhPTSRGVG---LWEDKLYLAT 149
Cdd:pfam13360  14 AELWRVDLETGLGGGVA--VDGGRLFVATGGGQLVALDAATGKLLWRQT-----------LSGEVLGaplVAGGRVFVVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 150 TDDHVVALDAKTGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEfgvrgyVVAFDAGSGKELW-RTFTIPGEGEP 228
Cdd:pfam13360  81 GDGSLIALDAADGRRLWSYQRSGEPLALRSSGSPAVVGDTVVAGFSSGK------LVALDPATGKVRWeAPLAAPRGTNE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1304137069 229 GHET---------WSGDDWKSGGGAAwmTGTYDKDTKTVYWGIGNASPwPGSMHPGDNLYTSS----VLALDPDSGKI 293
Cdd:pfam13360 155 LERLvditgtpvvAGGRVFASAYQGR--LVAFDAATGRRLWTREISGP-NGPILDGDLLYVVSddgeLYALDRATGAV 229
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 58-246 2.64e-15

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 78.05  E-value: 2.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  58 FSPLDQINtsNVKDLKPVWTFSTGVLEGH---EAPPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKRQLPDDLFQLHPT 134
Cdd:PRK11138   32 MSPLPQVE--NQFTPTTVWSTSVGDGVGDyysRLHPAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFSKNKS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 135 SR---GVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVqdykKGQYMTlMPLVVDGKVIVGGSggefgvRGYVVAFDAG 211
Cdd:PRK11138  110 ALlsgGVTVAGGKVYIGSEKGQVYALNAEDGEVAWQTKV----AGEALS-RPVVSDGLVLVHTS------NGMLQALNES 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1304137069 212 SGKELWR------TFTIPGEGEP----GHETWSGDDWK------SGGGAAW 246
Cdd:PRK11138  179 DGAVKWTvnldvpSLTLRGESAPatafGGAIVGGDNGRvsavlmEQGQLIW 229
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 68-218 4.35e-14

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 74.08  E-value: 4.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  68 NVKDLKPVW--TFSTGVLegheAPPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKRQLPddlfQLhpTSRGVG---LWE 142
Cdd:COG1520   113 DADDGEELWraRLSSEVL----AAPAVAGGRVVVRTGDGRVYALDAATGERLWSYQRPVP----AL--TLRGTSspvIVG 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 143 DKLYLATTDDHVVALDAKTGKVLWDTKVQdykkgqymtlMP--------LV-VDGKVIVggSGGEFGVRGY---VVAFDA 210
Cdd:COG1520   183 GAVLVGFANGKLVALDLANGQPLWEQRVA----------QPrgrtelerLVdVDGTPVV--DGGVVYAVAYqgrLAALDL 250


                  ....*...
gi 1304137069 211 GSGKELWR 218
Cdd:COG1520   251 RSGRVLWS 258
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 88-217 1.09e-12

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 69.58  E-value: 1.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  88 APPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKRQLPddlfQLhpTSRGVG---LWEDKLYLATTDDHVVALDAKTGKV 164
Cdd:TIGR03300 139 SPPLVANGLVVVRTNDGRLTALDAATGERLWTYSRVTP----PL--TLRGSAspvIADGGVLVGFAGGKLVALDLQTGQP 212

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1304137069 165 LWDTKVQdYKKGQyMTLMPLV-VDGKVIVGGsGGEFGV--RGYVVAFDAGSGKELW 217
Cdd:TIGR03300 213 LWEQRVA-LPKGR-TELERLVdVDGDPVVDG-GQVYAVsyQGRVAALDLRSGRVLW 265
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 102-218 1.93e-11

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 63.96  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 102 PMGQVIALNAKTGEEYWRYKRQLPddlfqlhpTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQymtl 181
Cdd:pfam13360   1 ADGVVTALDAATGAELWRVDLETG--------LGGGVAVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGA---- 68

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1304137069 182 mPLVVDGKVIVGGSGgefgvrGYVVAFDAGSGKELWR 218
Cdd:pfam13360  69 -PLVAGGRVFVVAGD------GSLIALDAADGRRLWS 98
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 88-219 3.98e-11

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 64.83  E-value: 3.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  88 APPIVNNGVMFVATPMGQVIALNAKTGEEYWryKRQLPddlfqlhpTSRGVGLWEDKLYLATTDDHVVALDAKTGKVLWd 167
Cdd:COG1520   227 GTPVVDGGVVYAVAYQGRLAALDLRSGRVLW--SRDLS--------SYTGLAVDGNNLYVTDDDGRVWALDRRNGAELW- 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1304137069 168 tkVQDYKKGQYMTlMPLVVDGKVIVGGSggefgvRGYVVAFDAGSGKELWRT 219
Cdd:COG1520   296 --KQDALLYRGLT-APVVLGDYVVVGDF------EGYLHWLSRDDGSLVARL 338
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 126-225 1.78e-10

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 62.91  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 126 DDLFQLHPTsrgvgLWEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGqymtlmPLVVDG-KVIVGGSGGEfgvrgy 204
Cdd:COG1520    46 KGYSRLAPA-----VAGDRVYAADADGRVAALDAATGKELWRVDLGEPLSG------GVGADGgLVVVGTEDGE------ 108

                          90       100
                  ....*....|....*....|.
gi 1304137069 205 VVAFDAGSGKELWRTfTIPGE 225
Cdd:COG1520   109 VIALDADDGEELWRA-RLSSE 128
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 88-221 4.61e-10

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 61.49  E-value: 4.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  88 APPIVNNGVMFVATPMGQVIALNAKTGEEYWRykrqlpddlfqlHPTS--RGVGLWEDKLYLATTDDHVVALDAKTGKVL 165
Cdd:TIGR03300 235 GDPVVDGGQVYAVSYQGRVAALDLRSGRVLWK------------RDASsyQGPAVDDNRLYVTDADGVVVALDRRSGSEL 302

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1304137069 166 WDtkvQDYKKGQYMTlMPLVVDGKVIVGGSggefgvRGYVVAFDAGSGKELWRTFT 221
Cdd:TIGR03300 303 WK---NDELKYRQLT-APAVLGGYLVVGDF------EGYLHWLDRDDGSFVARLKT 348
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 450-523 2.19e-08

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 56.36  E-value: 2.19e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1304137069 450 ADHFGELQAWDPATGKKVWQHDYKTsQLFGSVTAtAGDLVLAGGTNDRAFrIFNAKTGELLWEQKTNSGIMAMP 523
Cdd:COG1520    63 ADADGRVAALDAATGKELWRVDLGE-PLSGGVGA-DGGLVVVGTEDGEVI-ALDADDGEELWRARLSSEVLAAP 133
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 450-534 2.10e-07

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 53.10  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 450 ADHFGELQAWDPATGKKVWQHDYKTSQLFGSvTATAGDLVLAGGTNDRAFRIFNAKTGELLWEQKTNSGIMAMPMSYeVD 529
Cdd:cd10276    44 ADANGQVSAFNATTGKIIWETSLSGKGFLGG-TPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSDSQLLSPPTY-AD 121


                  ....*
gi 1304137069 530 GTQYI 534
Cdd:cd10276   122 GKIYV 126
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 450-523 4.24e-07

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 52.24  E-value: 4.24e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1304137069 450 ADHFGELQAWDPATGKKVWQHDYKtSQLFGSVTAtAGDLVLAGGTNDRAFrIFNAKTGELLWEQKTNSGIMAMP 523
Cdd:TIGR03300  71 ADADGTVAALDAETGKRLWRVDLD-ERLSGGVGA-DGGLVFVGTEKGEVI-ALDAEDGKELWRAKLSSEVLSPP 141
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 163-219 3.48e-06

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 49.43  E-value: 3.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1304137069 163 KVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEfgvrgyVVAFDAGSGKELWRT 219
Cdd:COG1520    33 KQLWSASVGDGVGKGYSRLAPAVAGDRVYAADADGR------VAALDAATGKELWRV 83
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 88-218 6.29e-06

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 48.77  E-value: 6.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  88 APPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKRQLP--------------------DDLFQLHPT--SRGVGLWE--- 142
Cdd:PRK11138  154 SRPVVSDGLVLVHTSNGMLQALNESDGAVKWTVNLDVPsltlrgesapatafggaivgGDNGRVSAVlmEQGQLIWQqri 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 143 -----------------------DKLYLATTDDHVVALDAKTGKVLWdtkvqdykKGQYMTLMPLVVDGKVIvggsggeF 199
Cdd:PRK11138  234 sqptgateidrlvdvdttpvvvgGVVYALAYNGNLVALDLRSGQIVW--------KREYGSVNDFAVDGGRI-------Y 298

                         170       180
                  ....*....|....*....|.
gi 1304137069 200 GV--RGYVVAFDAGSGKELWR 218
Cdd:PRK11138  299 LVdqNDRVYALDTRGGVELWS 319
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 32-166 6.91e-06

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 47.40  E-value: 6.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  32 PVTSARLENPEPGNWMLYRRTYDGQgFSPLDQintsnvKDLKPVWTFSTGVLEGHEAP---PIVNNGVMFVATPMGQVIA 108
Cdd:pfam13360  60 TLSGEVLGAPLVAGGRVFVVAGDGS-LIALDA------ADGRRLWSYQRSGEPLALRSsgsPAVVGDTVVAGFSSGKLVA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 109 LNAKTGEEYWRYKRQLP--------------------DDLFQLH--------PTSRGVGLWEDK-------------LYL 147
Cdd:pfam13360 133 LDPATGKVRWEAPLAAPrgtnelerlvditgtpvvagGRVFASAyqgrlvafDAATGRRLWTREisgpngpildgdlLYV 212

                         170
                  ....*....|....*....
gi 1304137069 148 ATTDDHVVALDAKTGKVLW 166
Cdd:pfam13360 213 VSDDGELYALDRATGAVVW 231
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 450-523 1.28e-05

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 47.62  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 450 ADHFGELQAWDPATGKKVWQHDY----------KTSQLFGSVTAtAGDLVLAGGTNDRAFrIFNAKTGELLWEQKTNSGI 519
Cdd:PRK11138   75 ADRAGLVKALDADTGKEIWSVDLsekdgwfsknKSALLSGGVTV-AGGKVYIGSEKGQVY-ALNAEDGEVAWQTKVAGEA 152


                  ....
gi 1304137069 520 MAMP 523
Cdd:PRK11138  153 LSRP 156
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 161-219 1.57e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 47.23  E-value: 1.57e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1304137069 161 TGKVLWDTKVQDYKKGQYMTLMPLVVDGKVIVGGSGGEfgvrgyVVAFDAGSGKELWRT 219
Cdd:TIGR03300  39 KVDQVWSASVGDGVGHYYLRLQPAVAGGKVYAADADGT------VAALDAETGKRLWRV 91
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 454-569 1.97e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 47.23  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 454 GELQAWDPATGKKVWQHDYKTSQL----FGSVTAtAGDLVLAGGTNDRaFRIFNAKTGELLWEQKTNSG----------- 518
Cdd:TIGR03300 155 GRLTALDAATGERLWTYSRVTPPLtlrgSASPVI-ADGGVLVGFAGGK-LVALDLQTGQPLWEQRVALPkgrtelerlvd 232

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1304137069 519 IMAMPMsyeVDGTQYIAVqsgwgvdaqriqdALAGKVAGFEnnVPQGGVIW 569
Cdd:TIGR03300 233 VDGDPV---VDGGQVYAV-------------SYQGRVAALD--LRSGRVLW 265
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 454-544 2.47e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 45.86  E-value: 2.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 454 GELQAWDPATGKKVWQHDYKTsqLFGSVTATAGDLVLAGGTNDRAFrIFNAKTGELLWEQKTNSGIMAMPmsyEVDGTQY 533
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLET--GLGGGVAVDGGRLFVATGGGQLV-ALDAATGKLLWRQTLSGEVLGAP---LVAGGRV 76

                          90
                  ....*....|....
gi 1304137069 534 IAV---QSGWGVDA 544
Cdd:pfam13360  77 FVVagdGSLIALDA 90
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 90-197 3.01e-05

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 46.46  E-value: 3.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  90 PIVNNGVMFVATPMGQVIALNAKTGEEYWryKRQLP--DDLFQLHptsrgvglweDKLYLATTDDHVVALDAKTGKVLWD 167
Cdd:PRK11138  252 PVVVGGVVYALAYNGNLVALDLRSGQIVW--KREYGsvNDFAVDG----------GRIYLVDQNDRVYALDTRGGVELWS 319

                          90       100       110
                  ....*....|....*....|....*....|
gi 1304137069 168 tkvQDYKKGQYMTlMPLVVDGKVIVGGSGG 197
Cdd:PRK11138  320 ---QSDLLHRLLT-APVLYNGYLVVGDSEG 345
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 148-208 1.10e-04

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 45.26  E-value: 1.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1304137069 148 ATTDDHVVALDAKTGKVLWDTKVqdyKKGQYMTLMPLVVDGK---VIVGGSGGEFGVR--GYVVAF 208
Cdd:cd10280   552 ATQDNYLRAFDKATGKELWEARL---PAGGQATPMTYEVDGKqyvVIAAGGHGSLGTKrgDSVIAY 614
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 89-121 1.36e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 39.05  E-value: 1.36e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1304137069   89 PPIVNNGVMFVATPMGQVIALNAKTGEEYWRYK 121
Cdd:smart00564   1 PVVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 450-555 1.55e-04

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 43.55  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069 450 ADHFGELQAWDPATGKKVWQHDYkTSQLFGSVTATAGDLVLAggTNDRAFRIFNAKTGELLWEQKTNSGIMAM--PMSYE 527
Cdd:pfam13360  39 ATGGGQLVALDAATGKLLWRQTL-SGEVLGAPLVAGGRVFVV--AGDGSLIALDAADGRRLWSYQRSGEPLALrsSGSPA 115

                          90       100
                  ....*....|....*....|....*...
gi 1304137069 528 VDGTQYIAVQSGWGVDAQRIQDalaGKV 555
Cdd:pfam13360 116 VVGDTVVAGFSSGKLVALDPAT---GKV 140
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 454-513 1.71e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 44.03  E-value: 1.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1304137069 454 GELQAWDPATGKKVWQHDYKTSQLF---GSVTATAGDLVLAGGTNDRaFRIFNAKTGELLWEQ 513
Cdd:COG1520   147 GRVYALDAATGERLWSYQRPVPALTlrgTSSPVIVGGAVLVGFANGK-LVALDLANGQPLWEQ 208
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 138-166 2.31e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 38.67  E-value: 2.31e-04
                           10        20
                   ....*....|....*....|....*....
gi 1304137069  138 VGLWEDKLYLATTDDHVVALDAKTGKVLW 166
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILW 30
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 143-178 1.06e-03

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 36.79  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1304137069 143 DKLYLATTDDHVVALDAKTGKVLWDTKVQDYKKGQY 178
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
Luminal_IRE1_like cd09213
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The ...
 87-174 1.13e-03

The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), eukaryotic translation Initiation Factor 2-Alpha Kinase 3 (EIF2AK3), and similar proteins. IRE1 and EIF2AK3 are serine/threonine protein kinases (STKs) and are type I transmembrane proteins that are localized in the endoplasmic reticulum (ER). They are kinase receptors that are activated through the release of BiP, a chaperone bound to their luminal domains under unstressed conditions. This results in dimerization through their luminal domains, allowing trans-autophosphorylation of their kinase domains and activation. They play roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), contains an endoribonuclease domain in its cytoplasmic side and acts as an ER stress sensor. It is the oldest and most conserved component of the UPR in eukaryotes. Its activation results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. EIF2AK3, also called PKR-like Endoplasmic Reticulum Kinase (PERK), phosphorylates the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. It functions as the central regulator of translational control during the UPR pathway. In addition to the eIF-2 alpha subunit, EIF2AK3 also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR.


Pssm-ID: 188873 [Multi-domain]  Cd Length: 312  Bit Score: 41.32  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  87 EAPPIV----NNGVMFVATPMGQVIALNAKTGEeYWRYKRQLPDDLFQLHPTSRGVGLWEDK-------LYLATTDDHVV 155
Cdd:cd09213    82 EASPLVsdtnEDDVVVVGSKRTSVFALDAKTGK-IIKTYRADGLPSTGGSDSDGNSTPGPDElqeeeelLYIGRTDYVLQ 160

                          90
                  ....*....|....*....
gi 1304137069 156 ALDAKTGKVLWDTKVQDYK 174
Cdd:cd09213   161 AIDPRSGKELWNVTYGEYE 179
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 454-514 3.67e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 39.31  E-value: 3.67e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1304137069 454 GELQAWDPATGKKVWQHDYKTSQLFGSVTAT---AGDLVLAGGTNDRAfRIFNAKTGELLWEQK 514
Cdd:pfam13360  83 GSLIALDAADGRRLWSYQRSGEPLALRSSGSpavVGDTVVAGFSSGKL-VALDPATGKVRWEAP 145
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 68-175 7.02e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 38.85  E-value: 7.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304137069  68 NVKDLKPVWTFSTGVLEGH---------EAPPIVNNGVMFVATPMGQVIALNAKTGEEYWRYKrqlpddlfqlHPTSRGV 138
Cdd:cd10276   182 NTGTGVDIWEFSVSEPRGRtelprmidsSVTYVVVGGYLYSTSYQGYLVALDFESGQFLWSRK----------ASGGTST 251

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1304137069 139 GL-WEDKLYLATTDDHVVALDAKTGKVLWDTKVQDYKK 175
Cdd:cd10276   252 STdANGRVYVGDGEGSLYCLDASTGDELWSQTVLLGRV 289
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 95-121 7.16e-03

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 34.47  E-value: 7.16e-03
                          10        20
                  ....*....|....*....|....*..
gi 1304137069  95 GVMFVATPMGQVIALNAKTGEEYWRYK 121
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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