|
Name |
Accession |
Description |
Interval |
E-value |
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
38-530 |
0e+00 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 568.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 38 KQPNILFIMADDLGYSDLGAFGGEIHTPNLDALTQEGRILTDYHTAPTCSPTRSQLISGTDHHLAGIGAMAELTPahlkG 117
Cdd:cd16025 1 GRPNILLILADDLGFSDLGCFGGEIPTPNLDALAAEGLRFTNFHTTALCSPTRAALLTGRNHHQVGMGTMAELAT----G 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 QPGYEGYLNERSLSIAEVLRDNGYRTYISGKWHLGltpetnahakgfdhsftllqgldlhfkqaptaykrnatytedgkq 197
Cdd:cd16025 77 KPGYEGYLPDSAATIAEVLKDAGYHTYMSGKWHLG--------------------------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 198 vaisslPDDFFSTNYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYDVGYDAIRNARIARQKQLG 277
Cdd:cd16025 112 ------PDDYYSTDDLTDKAIEYIDEQKAPDKPFFLYLAFGAPHAPLQAPKEWIDKYKGKYDAGWDALREERLERQKELG 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 278 LIPANFTAAEPiatqnaPQKYGKWNELSAEQKALEARRMEIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGAE 357
Cdd:cd16025 186 LIPADTKLTPR------PPGVPAWDSLSPEEKKLEARRMEVYAAMVEHMDQQIGRLIDYLKELGELDNTLIIFLSDNGAS 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 358 GFirgnygaesgfdnnlnnvgtassyhyvgPRWAEVSAAPFHLWKDTAGEGATTAPAIVKLPNQTQAQ-AIHHGFASVLD 436
Cdd:cd16025 260 AE----------------------------PGWANASNTPFRLYKQASHEGGIRTPLIVSWPKGIKAKgGIRHQFAHVID 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 437 VFPTVLEYANIAVPqGQYKGRQINTPSGYSWKSVLENKAQliRPAQFSFADELHGSKYARQGDWKIALQGKAELGTGTWE 516
Cdd:cd16025 312 IAPTILELAGVEYP-KTVNGVPQLPLDGVSLLPTLDGAAA--PSRRRTQYFELFGNRAIRKGGWKAVALHPPPGWGDQWE 388
|
490
....*....|....
gi 1294492365 517 LYNLNNDRGETKNL 530
Cdd:cd16025 389 LYDLAKDPSETHDL 402
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
30-554 |
3.12e-110 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 334.54 E-value: 3.12e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 30 SNGSVGTQKQPNILFIMADDLGYSDLGAFG-GEIHTPNLDALTQEGRILTDYH-TAPTCSPTRSQLISGTDHHLAGIGAM 107
Cdd:COG3119 14 AAAAAAAAKRPNILFILADDLGYGDLGCYGnPLIKTPNIDRLAAEGVRFTNAYvTSPVCSPSRASLLTGRYPHRTGVTDN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 108 AEltpahlkgqpGYEGYLNERSLSIAEVLRDNGYRTYISGKWHLgltpetnahakgfdhsftllqgldlhfkqaptaykr 187
Cdd:COG3119 94 GE----------GYNGGLPPDEPTLAELLKEAGYRTALFGKWHL------------------------------------ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 188 natytedgkqvaisslpddfFSTNYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGvydvgydairn 267
Cdd:COG3119 128 --------------------YLTDLLTDKAIDFLERQADKDKPFFLYLAFNAPHAPYQAPEEYLDKYDG----------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 268 ariarqkQLGLIPANFTAAEpiatqnapqkygkwnelsaEQKALEARRMEIYAGMVENLDANIGRVIQYLKRNHLYDNTL 347
Cdd:COG3119 177 -------KDIPLPPNLAPRD-------------------LTEEELRRARAAYAAMIEEVDDQVGRLLDALEELGLADNTI 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 348 IFFVSDNGAEGFIRGnygaesgfdnnlnnvgtassyhyvgprwaevsaapFHLWKDTAGEGATTAPAIVKLPNQTQAQAI 427
Cdd:COG3119 231 VVFTSDNGPSLGEHG-----------------------------------LRGGKGTLYEGGIRVPLIVRWPGKIKAGSV 275
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 428 HHGFASVLDVFPTVLEYANIAVPqgqykgrqiNTPSGYSWKSVLENKAQLIRPAQFSFADELHGSKYARQGDWKIALQGK 507
Cdd:COG3119 276 SDALVSLIDLLPTLLDLAGVPIP---------EDLDGRSLLPLLTGEKAEWRDYLYWEYPRGGGNRAIRTGRWKLIRYYD 346
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1294492365 508 aelGTGTWELYNLNNDRGETKNLAQDNPTKVQELIEVYNKYTQQNGV 554
Cdd:COG3119 347 ---DDGPWELYDLKNDPGETNNLAADYPEVVAELRALLEAWLKELGD 390
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
40-541 |
6.38e-92 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 288.29 E-value: 6.38e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGEIH-TPNLDALTQEGRILTD-YHTAPTCSPTRSQLISG--------TDHhlagIGAMAE 109
Cdd:cd16144 1 PNIVLILVDDLGWADLGCYGSKFYeTPNIDRLAKEGMRFTQaYAAAPVCSPSRASILTGqyparlgiTDV----IPGRRG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 110 LTPAHLKGQPGYEGYLNERSLSIAEVLRDNGYRTYISGKWHLGLTPETNAHAKGFDHSF--TLLQGLDLHFKQAPTAYKR 187
Cdd:cd16144 77 PPDNTKLIPPPSTTRLPLEEVTIAEALKDAGYATAHFGKWHLGGEGGYGPEDQGFDVNIggTGNGGPPSYYFPPGKPNPD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 188 NATYTEDGKQvaisslpddffsTNYFTDKLLSYLEsgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYDVGYDAIRN 267
Cdd:cd16144 157 LEDGPEGEYL------------TDRLTDEAIDFIE--QNKDKPFFLYLSHYAVHTPIQARPELIEKYEKKKKGLRKGQKN 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 268 AriarqkqlglipanftaaepiatqnapqkygkwnelsaeqkalearrmeIYAGMVENLDANIGRVIQYLKRNHLYDNTL 347
Cdd:cd16144 223 P-------------------------------------------------VYAAMIESLDESVGRILDALEELGLADNTL 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 348 IFFVSDNGaegfirGNYGAESGFDNNlnnvgtassyhyvgprwaevsaAPFHLWKDTAGEGATTAPAIVKLPNQTQAQAI 427
Cdd:cd16144 254 VIFTSDNG------GLSTRGGPPTSN----------------------APLRGGKGSLYEGGIRVPLIVRWPGVIKPGSV 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 428 HHGFASVLDVFPTVLEYANIAVPQGQykgrqinTPSGYSWKSVLENKAQ-LIRPAQF----SFADELHGSKYA-RQGDWK 501
Cdd:cd16144 306 SDVPVIGTDLYPTFLELAGGPLPPPQ-------HLDGVSLVPLLKGGEAdLPRRALFwhfpHYHGQGGRPASAiRKGDWK 378
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1294492365 502 IALQgkaeLGTGTWELYNLNNDRGETKNLAQDNPTKVQEL 541
Cdd:cd16144 379 LIEF----YEDGRVELYNLKNDIGETNNLAAEMPEKAAEL 414
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
40-550 |
2.54e-91 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 286.37 E-value: 2.54e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTDYHTAPTCSPTRSQLISGTDHHLAGIgamaelTPAHLKGQ 118
Cdd:cd16146 1 PNVILILTDDQGYGDLGFHGNPiLKTPNLDRLAAESVRFTNFHVSPVCAPTRAALLTGRYPFRTGV------WHTILGRE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 119 pgyegYLNERSLSIAEVLRDNGYRTYISGKWHLGLTPETNAHAKGFDHSFTLLQGldlHFKQAPTAYKR---NATYTEDG 195
Cdd:cd16146 75 -----RMRLDETTLAEVFKDAGYRTGIFGKWHLGDNYPYRPQDRGFDEVLGHGGG---GIGQYPDYWGNdyfDDTYYHNG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 196 KQVaisslPDDFFSTNYFTDKLLSYLEsgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRgvyDVGYDairnariarqkq 275
Cdd:cd16146 147 KFV-----KTEGYCTDVFFDEAIDFIE--ENKDKPFFAYLATNAPHGPLQVPDKYLDPYK---DMGLD------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 276 lglipanftaaEPIATqnapqkygkwnelsaeqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNG 355
Cdd:cd16146 205 -----------DKLAA---------------------------FYGMIENIDDNVGRLLAKLKELGLEENTIVIFMSDNG 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 356 aegfirGNYGAESGFDNNLNNvgtassyhyvgprwaevsaapfhlWKDTAGEGATTAPAIVKLPNQTQAQAIHHGFASVL 435
Cdd:cd16146 247 ------PAGGVPKRFNAGMRG------------------------KKGSVYEGGHRVPFFIRWPGKILAGKDVDTLTAHI 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 436 DVFPTVLEYANIAVPQGqykgrqiNTPSGYSWKSVLENKAQLIRPAQF---SFADELHGSKYA----RQGDWKIaLQGKA 508
Cdd:cd16146 297 DLLPTLLDLCGVKLPEG-------IKLDGRSLLPLLKGESDPWPERTLfthSGRWPPPPKKKRnaavRTGRWRL-VSPKG 368
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1294492365 509 ElgtgTWELYNLNNDRGETKNLAQDNPTKVQELIEVYNKYTQ 550
Cdd:cd16146 369 F----QPELYDIENDPGEENDVADEHPEVVKRLKAAYEAWWD 406
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
39-531 |
3.52e-77 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 249.02 E-value: 3.52e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTDYH-TAPTCSPTRSQLISGTDHHLAGIGamaeltpaHLK 116
Cdd:cd16026 1 KPNIVVILADDLGYGDLGCYGSPlIKTPNIDRLAAEGVRFTDFYaAAPVCSPSRAALLTGRYPVRVGLP--------GVV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 117 GQPGYEGYLNERSLSIAEVLRDNGYRTYISGKWHLGLTPET--NAHakGFDHSFTLLQGLDlhfkQAPTAYKRNATYTED 194
Cdd:cd16026 73 GPPGSKGGLPPDEITIAEVLKKAGYRTALVGKWHLGHQPEFlpTRH--GFDEYFGIPYSND----MWPFPLYRNDPPGPL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 195 ---GKQVAISSLPDDFFS-TNYFTDKLLSYLEsgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGvydvgydairnari 270
Cdd:cd16026 147 pplMENEEVIEQPADQSSlTQRYTDEAVDFIE--RNKDQPFFLYLAHTMPHVPLFASEKFKGRSGA-------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 271 arqkqlGLipanftaaepiatqnapqkygkwnelsaeqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLYDNTLIFF 350
Cdd:cd16026 211 ------GL----------------------------------------YGDVVEELDWSVGRILDALKELGLEENTLVIF 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 351 VSDNGAegfiRGNYGAESGfdnnlnnvgtassyhyvgprwaevSAAPFHLWKDTAGEGATTAPAIVKLPNQTQAQAIHHG 430
Cdd:cd16026 245 TSDNGP----WLEYGGHGG------------------------SAGPLRGGKGTTWEGGVRVPFIAWWPGVIPAGTVSDE 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 431 FASVLDVFPTVLEYANIAVPQgqykGRQINtpsGYSWKSVLENKAQLIRPAQFSFADELHGsKYARQGDWKIALQ----- 505
Cdd:cd16026 297 LASTMDLLPTLAALAGAPLPE----DRVID---GKDISPLLLGGSKSPPHPFFYYYDGGDL-QAVRSGRWKLHLPttyrt 368
|
490 500 510
....*....|....*....|....*....|.
gi 1294492365 506 -----GKAELGTGTWELYNLNNDRGETKNLA 531
Cdd:cd16026 369 gtdpgGLDPTKLEPPLLYDLEEDPGETYNVA 399
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
40-535 |
1.07e-76 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 248.28 E-value: 1.07e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGtdhhlagigamaeLTPAH--L 115
Cdd:cd16145 1 PNIIFILADDLGYGDLGCYGQKkIKTPNLDRLAAEGMRFTQhYAGAPVCAPSRASLLTG-------------LHTGHtrV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 116 KGQPGYEG--YLNERSLSIAEVLRDNGYRTYISGKWHLG-LTPETNAHAKGFDHSFTLLQGLDLHFKQaPTAYKRNATYT 192
Cdd:cd16145 68 RGNSEPGGqdPLPPDDVTLAEVLKKAGYATAAFGKWGLGgPGTPGHPTKQGFDYFYGYLDQVHAHNYY-PEYLWRNGEKV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 193 EDGKQVAISSLPDDF-------FSTNYFTDKLLSYLEsgKNSGKPFFAYAAYTAPHWPIQAPseyrdryrgvyDVGYDai 265
Cdd:cd16145 147 PLPNNVIPPLDEGNNagggggtYSHDLFTDEALDFIR--ENKDKPFFLYLAYTLPHAPLQVP-----------DDGPY-- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 266 rnariarqKQLGLIPanftaaepiatqnAPQKYGKWNELSAEqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLYDN 345
Cdd:cd16145 212 --------KYKPKDP-------------GIYAYLPWPQPEKA-----------YAAMVTRLDRDVGRILALLKELGIDEN 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 346 TLIFFVSDNGAEgfirgNYGAESGFDNNLNnvgtassyhyvgprwaevSAAPFHLWKDTAGEGATTAPAIVKLPNQTQA- 424
Cdd:cd16145 260 TLVVFTSDNGPH-----SEGGSEHDPDFFD------------------SNGPLRGYKRSLYEGGIRVPFIARWPGKIPAg 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 425 QAIHHGFASVlDVFPTVLEYANIAVPQGqykgrqINtpsGYSWKSVL--ENKAQLIRPAQFSFaDELHGSKYARQGDWKI 502
Cdd:cd16145 317 SVSDHPSAFW-DFMPTLADLAGAEPPED------ID---GISLLPTLlgKPQQQQHDYLYWEF-YEGGGAQAVRMGGWKA 385
|
490 500 510
....*....|....*....|....*....|...
gi 1294492365 503 ALQGKaelGTGTWELYNLNNDRGETKNLAQDNP 535
Cdd:cd16145 386 VRHGK---KDGPFELYDLSTDPGETNNLAAQHP 415
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
40-531 |
6.42e-64 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 214.34 E-value: 6.42e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGaFGG--EIHTPNLDALTQEGRILTDYHTAPTCSPTRSQLISGTDHHLAGIGAMAeLTPAHLKG 117
Cdd:cd16029 1 PHIVFILADDLGWNDVG-FHGsdQIKTPNLDALAADGVILNNYYVQPICTPSRAALMTGRYPIHTGMQHGV-ILAGEPYG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 QPgyegyLNERSLsiAEVLRDNGYRTYISGKWHLG-----LTPEtnahAKGFDHSFTLLQGLDLHFKQAPTAYKRNATYT 192
Cdd:cd16029 79 LP-----LNETLL--PQYLKELGYATHLVGKWHLGfytweYTPT----NRGFDSFYGYYGGAEDYYTHTSGGANDYGNDD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 193 EDGKQVAISSLPDDfFSTNYFTDKLLSYLESgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYDvgydairnariar 272
Cdd:cd16029 148 LRDNEEPAWDYNGT-YSTDLFTDRAVDIIEN-HDPSKPLFLYLAFQAVHAPLQVPPEYADPYEDKFA------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 273 qkqlglipanftaaePIATqnapqkygkwnelsaeqkalEARRMeiYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVS 352
Cdd:cd16029 213 ---------------HIKD--------------------EDRRT--YAAMVSALDESVGNVVDALKAKGMLDNTLIVFTS 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 353 DNGaegfirgnyGAESGFDnnlnnvgTASSYhyvgprwaevsaaPFHLWKDTAGEGATTAPAIV---KLPNQTqaQAIHH 429
Cdd:cd16029 256 DNG---------GPTGGGD-------GGSNY-------------PLRGGKNTLWEGGVRVPAFVwspLLPPKR--GTVSD 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 430 GFASVLDVFPTVLEYANIAVPqgqyKGRQINtpsGYS-WKSVLENKA----QLIRPAQFSFADELHGSkyARQGDWKIaL 504
Cdd:cd16029 305 GLMHVTDWLPTLLSLAGGDPD----DLPPLD---GVDqWDALSGGAPsprtEILLNIDDITRTTGGAA--IRVGDWKL-I 374
|
490 500
....*....|....*....|....*..
gi 1294492365 505 QGKAelgtgtweLYNLNNDRGETKNLA 531
Cdd:cd16029 375 VGKP--------LFNIENDPCERNDLA 393
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
40-531 |
1.78e-62 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 210.52 E-value: 1.78e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGE--IHTPNLDALTQEGRILTDYHT-APTCSPTRSQLISGTDHH---LAGIGAMAELTPA 113
Cdd:cd16143 1 PNIVIILADDLGYGDISCYNPDskIPTPNIDRLAAEGMRFTDAHSpSSVCTPSRYGLLTGRYPWrsrLKGGVLGGFSPPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 114 HLKGQPgyegylnerslSIAEVLRDNGYRTYISGKWHLGLT-------PETNAHAKGFDHSFTLLQGldlhfkqaPTAYK 186
Cdd:cd16143 81 IEPDRV-----------TLAKMLKQAGYRTAMVGKWHLGLDwkkkdgkKAATGTGKDVDYSKPIKGG--------PLDHG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 187 RNATYTEDGKQVaissLPDdffstnyFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIqAPSEyrdRYRGVYDVGydair 266
Cdd:cd16143 142 FDYYFGIPASEV----LPT-------LTDKAVEFIDQHAKKDKPFFLYFALPAPHTPI-VPSP---EFQGKSGAG----- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 267 nariarqkqlglipanftaaepiatqnapqkygkwnelsaeqkalearrmeIYAGMVENLDANIGRVIQYLKRNHLYDNT 346
Cdd:cd16143 202 ---------------------------------------------------PYGDFVYELDWVVGRILDALKELGLAENT 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 347 LIFFVSDNGAEGFIRGNYGAESGFDnnlnnvgtaSSYHYVGprwaevsaapfhlWKDTAGEGATTAPAIVKLPNQTQAQA 426
Cdd:cd16143 231 LVIFTSDNGPSPYADYKELEKFGHD---------PSGPLRG-------------MKADIYEGGHRVPFIVRWPGKIPAGS 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 427 IHHGFASVLDVFPTVLEYANIAVPQGQykgrqinTPSGYSWKSVL-ENKAQLIRPAQFSfadELHGSKYA-RQGDWKIAL 504
Cdd:cd16143 289 VSDQLVSLTDLFATLAAIVGQKLPDNA-------AEDSFSFLPALlGPKKQEVRESLVH---HSGNGSFAiRKGDWKLID 358
|
490 500 510
....*....|....*....|....*....|....*..
gi 1294492365 505 QG----------KAELGTGTWELYNLNNDRGETKNLA 531
Cdd:cd16143 359 GTgsggfsyprgKEKLGLPPGQLYNLSTDPGESNNLY 395
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
40-533 |
4.05e-57 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 195.42 E-value: 4.05e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGEIHTPNLDALTQEGRILTDYH-TAPTCSPTRSQLISGTDHHLAGIGAMAeltpahlkgq 118
Cdd:cd16027 1 PNILWIIADDLSPDLGGYGGNVVKTPNLDRLAAEGVRFTNAFtTAPVCSPSRSALLTGLYPHQNGAHGLR---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 119 pGYEGYLNERSLSIAEVLRDNGYRTYISGKWHlgltpetnaHAKGFDHSFTLLQGLDLHFKQAPTAYKRNAtytedgkqv 198
Cdd:cd16027 71 -SRGFPLPDGVKTLPELLREAGYYTGLIGKTH---------YNPDAVFPFDDEMRGPDDGGRNAWDYASNA--------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 199 aisslpDDFFSTnyftdkllsylesgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRgvydvgYDAIRnariarqkqlgl 278
Cdd:cd16027 132 ------ADFLNR--------------AKKGQPFFLWFGFHDPHRPYPPGDGEEPGYD------PEKVK------------ 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 279 IPANFtaaepiatQNAPqkygkwnelsaeqkalEARR-MEIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGAe 357
Cdd:cd16027 174 VPPYL--------PDTP----------------EVREdLADYYDEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHGM- 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 358 GFIRGnygaesgfdnnlnnvgtassyhyvgprwaevsaapfhlwKDTAGEGATTAPAIVKLPNQTQAQAIHHGFASVLDV 437
Cdd:cd16027 229 PFPRA---------------------------------------KGTLYDSGLRVPLIVRWPGKIKPGSVSDALVSFIDL 269
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 438 FPTVLEYANIAVPQGqYKGRqintpsgySWKSVLENKAQLIRPAQFSFADElHGSKY-----ARQGDWKIALQGKAElgt 512
Cdd:cd16027 270 APTLLDLAGIEPPEY-LQGR--------SFLPLLKGEKDPGRDYVFAERDR-HDETYdpirsVRTGRYKYIRNYMPE--- 336
|
490 500
....*....|....*....|.
gi 1294492365 513 gtwELYNLNNDRGETKNLAQD 533
Cdd:cd16027 337 ---ELYDLKNDPDELNNLADD 354
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
38-543 |
8.29e-57 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 194.71 E-value: 8.29e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 38 KQPNILFIMADDLGYSDLGAFGG-EIHTPNLDALTQEGRILTDYHTA-----PTCSPTRSQLISG-TDHHLAGIGAMAEl 110
Cdd:cd16155 1 KKPNILFILADDQRADTIGALGNpEIQTPNLDRLARRGTSFTNAYNMggwsgAVCVPSRAMLMTGrTLFHAPEGGKAAI- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 111 tpahlkgqpgyegylNERSLSIAEVLRDNGYRTYISGKWHlgltpetnahakgfdhsftllqgldlhfkqaptaykrnat 190
Cdd:cd16155 80 ---------------PSDDKTWPETFKKAGYRTFATGKWH---------------------------------------- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 191 ytedgkqvaisslpddffstNYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYrgvydvGYDAIRnari 270
Cdd:cd16155 105 --------------------NGFADAAIEFLEEYKDGDKPFFMYVAFTAPHDPRQAPPEYLDMY------PPETIP---- 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 271 arqkqlglIPANFTAAEPIatQNAPQKYGKwnELSA----EQKALEARRMEIYAgMVENLDANIGRVIQYLKRNHLYDNT 346
Cdd:cd16155 155 --------LPENFLPQHPF--DNGEGTVRD--EQLApfprTPEAVRQHLAEYYA-MITHLDAQIGRILDALEASGELDNT 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 347 LIFFVSDNGAegfirgnygaesgfdnnlnNVGtasSYHYVGprwaevsaapfhlwKDTAGEGATTAPAIVKLPNQTQAQA 426
Cdd:cd16155 222 IIVFTSDHGL-------------------AVG---SHGLMG--------------KQNLYEHSMRVPLIISGPGIPKGKR 265
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 427 IHHgFASVLDVFPTVLEYANIAVPQgqykgrqinTPSGYSWKSVLENKAQLIRPAQF-SFADelhGSKYARQGDWK-IAL 504
Cdd:cd16155 266 RDA-LVYLQDVFPTLCELAGIEIPE---------SVEGKSLLPVIRGEKKAVRDTLYgAYRD---GQRAIRDDRWKlIIY 332
|
490 500 510
....*....|....*....|....*....|....*....
gi 1294492365 505 QGKAElgtgTWELYNLNNDRGETKNLAqDNPTKVQELIE 543
Cdd:cd16155 333 VPGVK----RTQLFDLKKDPDELNNLA-DEPEYQERLKK 366
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
39-530 |
1.41e-55 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 192.40 E-value: 1.41e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGTDHHLAGIgamaeltpahlk 116
Cdd:cd16034 1 KPNILFIFADQHRAQALGCAGDDpVKTPNLDRLAKEGVVFTNaVSNYPVCSPYRASLLTGQYPLTNGV------------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 117 gqpgyegYLNERSLS-----IAEVLRDNGYRT-YIsGKWHLGLTPETNAHAK----------GFDHSFTLLQGLDlHFKq 180
Cdd:cd16034 69 -------FGNDVPLPpdaptIADVLKDAGYRTgYI-GKWHLDGPERNDGRADdytppperrhGFDYWKGYECNHD-HNN- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 181 apTAYkrnatYTEDGKQVAISSlpddfFSTNYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWP-IQAPSEYRDRYrgvyd 259
Cdd:cd16034 139 --PHY-----YDDDGKRIYIKG-----YSPDAETDLAIEYLENQADKDKPFALVLSWNPPHDPyTTAPEEYLDMY----- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 260 vgydairnariaRQKQLGLIPanftaaepiatqNAPqkygkwneLSAEQKALEARRMEIYAGMVENLDANIGRVIQYLKR 339
Cdd:cd16034 202 ------------DPKKLLLRP------------NVP--------EDKKEEAGLREDLRGYYAMITALDDNIGRLLDALKE 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 340 NHLYDNTLIFFVSDNGaegfirgnygaESGFDNNLNNVGTAssyhyvgprWAEVSAAPFhlwkdtagegattapaIVKLP 419
Cdd:cd16034 250 LGLLENTIVVFTSDHG-----------DMLGSHGLMNKQVP---------YEESIRVPF----------------IIRYP 293
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 420 NQTQAQAIHHGFASVLDVFPTVLEYANIAVPQgqykgrqinTPSGYSWKSVLENK---------AQLIRPAQFSFADELH 490
Cdd:cd16034 294 GKIKAGRVVDLLINTVDIMPTLLGLCGLPIPD---------TVEGRDLSPLLLGGkddepdsvlLQCFVPFGGGSARDGG 364
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1294492365 491 GSKYARQGDWKIALQGKaelgtGTWELYNLNNDRGETKNL 530
Cdd:cd16034 365 EWRGVRTDRYTYVRDKN-----GPWLLFDNEKDPYQLNNL 399
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
40-452 |
3.63e-55 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 186.10 E-value: 3.63e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGG-EIHTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGTDHHLAGIGamaeltpahlkG 117
Cdd:cd16022 1 PNILLIMTDDLGYDDLGCYGNpDIKTPNLDRLAAEGVRFTNaYVASPVCSPSRASLLTGRYPHRHGVR-----------G 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 QPGYEGYLNERSLSIAEVLRDNGYRTYISGKWHlgltpetnahakgfdhsftllqgldlhfkqaptaykrnatytedgkq 197
Cdd:cd16022 70 NVGNGGGLPPDEPTLAELLKEAGYRTALIGKWH----------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 198 vaisslpddffstnyftDKLLSYLESgKNSGKPFFAYAAYTAPHWPIqapseyrdryrgvydvgydairnariarqkqlg 277
Cdd:cd16022 103 -----------------DEAIDFIER-RDKDKPFFLYVSFNAPHPPF--------------------------------- 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 278 lipanftaaepiatqnapqkygkwnelsaeqkalearrmeIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGAE 357
Cdd:cd16022 132 ----------------------------------------AYYAMVSAIDDQIGRILDALEELGLLDNTLIVFTSDHGDM 171
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 358 GFIRGNYGaesgfdnnlnnvgtassyhyvgprwaevsaapfhlWKDTAGEGATTAPAIVKLPNQTQAQAIHHGFASVLDV 437
Cdd:cd16022 172 LGDHGLRG-----------------------------------KKGSLYEGGIRVPFIVRWPGKIPAGQVSDALVSLLDL 216
|
410
....*....|....*
gi 1294492365 438 FPTVLEYANIAVPQG 452
Cdd:cd16022 217 LPTLLDLAGIEPPEG 231
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
40-530 |
4.11e-52 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 182.41 E-value: 4.11e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTDYHTAPTCSPTRSQLISGTDHHLAGIGAmaeltpahlkgq 118
Cdd:cd16151 1 PNIILIMADDLGYECIGCYGGEsYKTPNIDALAAEGVRFNNAYAQPLCTPSRVQLMTGKYNFRNYVVF------------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 119 pgyeGYLNERSLSIAEVLRDNGYRTYISGKWHLG---LTPETNAHAkGFDHsFTLLQGLDlhfkqAPTAYKRNAT---YT 192
Cdd:cd16151 69 ----GYLDPKQKTFGHLLKDAGYATAIAGKWQLGggrGDGDYPHEF-GFDE-YCLWQLTE-----TGEKYSRPATptfNI 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 193 EDGKQVAISslpDDFFSTNYFTDKLLSYLEsgKNSGKPFFAYAAYTAPHWPIQA--PSEYRDRYRGVYdvgydairnari 270
Cdd:cd16151 138 RNGKLLETT---EGDYGPDLFADFLIDFIE--RNKDQPFFAYYPMVLVHDPFVPtpDSPDWDPDDKRK------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 271 arqkqlglipanftaaepiatqnapqkygkwnelsaeqkaleARRMEIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFF 350
Cdd:cd16151 201 ------------------------------------------KDDPEYFPDMVAYMDKLVGKLVDKLEELGLRENTIIIF 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 351 VSDNGAEGFIRGNYGAesgfdnnlnnvgtassyhyvgprwAEVSAApfhlwKDTAGEGATTAPAIVKLPNQTQAQAIHHG 430
Cdd:cd16151 239 TGDNGTHRPITSRTNG------------------------REVRGG-----KGKTTDAGTHVPLIVNWPGLIPAGGVSDD 289
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 431 FASVLDVFPTVLEYANIAVPqgqyKGRQINtpsGYSWKSVLENKAQLIRPAQFSFADELH----GSKYARQGDWKIALQG 506
Cdd:cd16151 290 LVDFSDFLPTLAELAGAPLP----EDYPLD---GRSFAPQLLGKTGSPRREWIYWYYRNPhkkfGSRFVRTKRYKLYADG 362
|
490 500
....*....|....*....|....
gi 1294492365 507 KaelgtgtweLYNLNNDRGETKNL 530
Cdd:cd16151 363 R---------FFDLREDPLEKNPL 377
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
40-531 |
7.37e-52 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 181.58 E-value: 7.37e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGEIH----TPNLDALTQEGRILTDYHTAPTCSPTRSQLISGTDHHLAGigamaeLTPAHL 115
Cdd:cd16142 1 PNILVILGDDIGWGDLGCYGGGIGrgapTPNIDRLAKEGLRFTSFYVEPSCTPGRAAFITGRHPIRTG------LTTVGL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 116 KGQPGYegyLNERSLSIAEVLRDNGYRTYISGKWHLGLTPETNAHAKGFDHsftllqgldlhfkqaptaYKRNATYTEDG 195
Cdd:cd16142 75 PGSPGG---LPPWEPTLAELLKDAGYATAQFGKWHLGDEDGRLPTDHGFDE------------------FYGNLYHTIDE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 196 kqvaisslpddffstnYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYdvgydairnariarqkq 275
Cdd:cd16142 134 ----------------EIVDKAIDFIKRNAKADKPFFLYVNFTKMHFPTLPSPEFEGKSSGKG----------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 276 lglipanftaaepiatqnapqKYGkwnelsaeqkalearrmeiyAGMVEnLDANIGRVIQYLKRNHLYDNTLIFFVSDNG 355
Cdd:cd16142 181 ---------------------KYA--------------------DSMVE-LDDHVGQILDALDELGIADNTIVIFTTDNG 218
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 356 AEGFI--RGNYGaesgfdnnlnnvgtassyhyvgprwaevsaaPFHLWKDTAGEGATTAPAIVKLPNQTQAQAIHHGFAS 433
Cdd:cd16142 219 PEQDVwpDGGYT-------------------------------PFRGEKGTTWEGGVRVPAIVRWPGKIKPGRVSNEIVS 267
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 434 VLDVFPTVLEYANIAVPQGQYKG--RQINtpsGYSWKSVLENKAQLIRPAQFSF--ADELHGSKYarqGDWKIALQGKAE 509
Cdd:cd16142 268 HLDWFPTLAALAGAPDPKDKLLGkdRHID---GVDQSPFLLGKSEKSRRSEFFYfgEGELGAVRW---KNWKVHFKAQED 341
|
490 500 510
....*....|....*....|....*....|.
gi 1294492365 510 LGTGTWE---------LYNLNNDRGETKNLA 531
Cdd:cd16142 342 TGGPTGEpfyvltfplIFNLRRDPKERYDVT 372
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
40-447 |
2.91e-49 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 172.22 E-value: 2.91e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGEIH-TPNLDALTQEGRILTDYH-TAPTCSPTRSQLISGTDHHLAGIGAMaeltpahlkg 117
Cdd:pfam00884 1 PNVVLVLGESLRAPDLGLYGYPRPtTPFLDRLAEEGLLFSNFYsGGTLTAPSRFALLTGLPPHNFGSYVS---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 qpgYEGYLNERSLSIAEVLRDNGYRTYISGKWHLGLTPETNAHAKGFDHSFTLLQGLDLHfkqaptAYKRNATYTEDGKQ 197
Cdd:pfam00884 71 ---TPVGLPRTEPSLPDLLKRAGYNTGAIGKWHLGWYNNQSPCNLGFDKFFGRNTGSDLY------ADPPDVPYNCSGGG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 198 VaisslpddffSTNYFTDKLLSYLesgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYDvgydairnariarqkqlg 277
Cdd:pfam00884 142 V----------SDEALLDEALEFL---DNNDKPFFLVLHTLGSHGPPYYPDRYPEKYATFKP------------------ 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 278 lipanftaaepiatqnapqkygkwnelsaeQKALEARRMEIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGAE 357
Cdd:pfam00884 191 ------------------------------SSCSEEQLLNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTSDHGES 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 358 GFIRGNYGAESGFDNnlnnvgtassyhyvgprwaevsaapfhlwkdtAGEGATTAPAIVKLPNQTQAQAIHHGFASVLDV 437
Cdd:pfam00884 241 LGEGGGYLHGGKYDN--------------------------------APEGGYRVPLLIWSPGGKAKGQKSEALVSHVDL 288
|
410
....*....|
gi 1294492365 438 FPTVLEYANI 447
Cdd:pfam00884 289 FPTILDLAGI 298
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
38-541 |
3.01e-48 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 173.48 E-value: 3.01e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 38 KQPNILFIMADDLGYSDLGAFGGEI-HTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGTdHhlagigamaeltpAHL 115
Cdd:cd16031 1 KRPNIIFILTDDHRYDALGCYGNPIvKTPNIDRLAKEGVRFDNaFVTTSICAPSRASILTGQ-Y-------------SHR 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 116 KGQPGYEGYLNERSL-SIAEVLRDNGYRTYISGKWHLGLtpETNAHAKGFDHSFTLL-QGldlhfkqaptAYKRNATYTE 193
Cdd:cd16031 67 HGVTDNNGPLFDASQpTYPKLLRKAGYQTAFIGKWHLGS--GGDLPPPGFDYWVSFPgQG----------SYYDPEFIEN 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 194 DGKQvaisslPDDFFSTNYFTDKLLSYLESGKNSgKPFFAYAAYTAPHwpiqAPSEYRDRYRGVYDvgydairNARIARq 273
Cdd:cd16031 135 GKRV------GQKGYVTDIITDKALDFLKERDKD-KPFCLSLSFKAPH----RPFTPAPRHRGLYE-------DVTIPE- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 274 kqlgliPANFT----AAEPIATQNAPQK-----YGKWNELSAEQkaleaRRMEIYAGMVENLDANIGRVIQYLKRNHLYD 344
Cdd:cd16031 196 ------PETFDdddyAGRPEWAREQRNRirgvlDGRFDTPEKYQ-----RYMKDYLRTVTGVDDNVGRILDYLEEQGLAD 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 345 NTLIFFVSDNgaeGFIRGNYGaesgfdnnlnnvgtassyhYVGPRWA-EVSAapfhlwkdtagegatTAPAIVKLPNQTQ 423
Cdd:cd16031 265 NTIIIYTSDN---GFFLGEHG-------------------LFDKRLMyEESI---------------RVPLIIRDPRLIK 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 424 AQAIHHGFASVLDVFPTVLEYANIAVPQgQYKGRqintpsgySWKSVLENKAQLIRPAQFSFADELHGSKYA-------R 496
Cdd:cd16031 308 AGTVVDALVLNIDFAPTILDLAGVPIPE-DMQGR--------SLLPLLEGEKPVDWRKEFYYEYYEEPNFHNvpthegvR 378
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1294492365 497 QGDWKialqgkaeL-----GTGTWELYNLNNDRGETKNLAqDNP---TKVQEL 541
Cdd:cd16031 379 TERYK--------YiyyygVWDEEELYDLKKDPLELNNLA-NDPeyaEVLKEL 422
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
40-535 |
3.37e-45 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 164.70 E-value: 3.37e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGEI-HTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGTDHHLAGIGAMAELTPAHLKG 117
Cdd:cd16033 1 PNILFIMTDQQRYDTLGCYGNPIvKTPNIDRLAAEGVRFTNaYTPSPVCCPARASLLTGLYPHEHGVLNNVENAGAYSRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 QP-GYEGYLnerslsiaEVLRDNGYRTYISGKWHLGltPETNAHAKGFDHsftllqgldlhfkqaptaykrnatytedgk 196
Cdd:cd16033 81 LPpGVETFS--------EDLREAGYRNGYVGKWHVG--PEETPLDYGFDE------------------------------ 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 197 qvaisSLPDDFFSTNYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYrgvydvgydaiRNARIARqkql 276
Cdd:cd16033 121 -----YLPVETTIEYFLADRAIEMLEELAADDKPFFLRVNFWGPHDPYIPPEPYLDMY-----------DPEDIPL---- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 277 gliPANFtaAEPIAtqNAPQKY----GKWNeLSAEQKALEARRMEIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVS 352
Cdd:cd16033 181 ---PESF--ADDFE--DKPYIYrrerKRWG-VDTEDEEDWKEIIAHYWGYITLIDDAIGRILDALEELGLADDTLVIFTS 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 353 DNG----AEG-FIRGNYGAEsgfdnnlnnvgtaSSYHyvgprwaevsaapfhlwkdtagegattAPAIVKLPNQTQAQAI 427
Cdd:cd16033 253 DHGdalgAHRlWDKGPFMYE-------------ETYR---------------------------IPLIIKWPGVIAAGQV 292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 428 HHGFASVLDVFPTVLEYANIAVPqgqykgrqiNTPSGYSWKSVLENKAQL-IRPAQFSfadELHGSKY------ARQGDW 500
Cdd:cd16033 293 VDEFVSLLDLAPTILDLAGVDVP---------PKVDGRSLLPLLRGEQPEdWRDEVVT---EYNGHEFylpqrmVRTDRY 360
|
490 500 510
....*....|....*....|....*....|....*
gi 1294492365 501 KIALQgkaelGTGTWELYNLNNDRGETKNLAQDNP 535
Cdd:cd16033 361 KYVFN-----GFDIDELYDLESDPYELNNLIDDPE 390
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
39-530 |
2.56e-42 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 156.09 E-value: 2.56e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYSDLGAFGGE--IHTPNLDALTQEGRILTDYHTA-PTCSPTRSQLISGTDHHLAGIGAmaELTPAHL 115
Cdd:cd16161 1 KPNFLLLFADDLGWGDLGANWAPnaILTPNLDKLAAEGTRFVDWYSAaSVCSPSRASLMTGRLGLRNGVGH--NFLPTSV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 116 KGQPgyegyLNERSLsiAEVLRDNGYRTYISGKWHLGLTPETNAHAKGFDHSFTLlqgldlhfkqaptaykrnaTYTEDg 195
Cdd:cd16161 79 GGLP-----LNETTL--AEVLRQAGYATGMIGKWHLGQREAYLPNSRGFDYYFGI-------------------PFSHD- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 196 kqvaiSSLPDDffstnyFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYrdryrgvydvgydairnariarqkq 275
Cdd:cd16161 132 -----SSLADR------YAQFATDFIQRASAKDRPFFLYAALAHVHVPLANLPRF------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 276 lglipanftaaepiatQNAPQKYGkwnelsaeqkalearrmeIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNG 355
Cdd:cd16161 176 ----------------QSPTSGRG------------------PYGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNG 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 356 AEgfirgNYGAESGfdnnlnnvgtassyhyVGP-RWAEVSAAPFHLWKDTAGEGATTAPAIVKLPNQTQAQAIHHGFASV 434
Cdd:cd16161 222 PW-----EVKCELA----------------VGPgTGDWQGNLGGSVAKASTWEGGHREPAIVYWPGRIPANSTSAALVST 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 435 LDVFPTVLEYANIAVPQGQ-YKGRQINtpsgyswkSVLENKAQLIRPAQFSFADELHGS---KYARQGDWKI--ALQG-K 507
Cdd:cd16161 281 LDIFPTVVALAGASLPPGRiYDGKDLS--------PVLFGGSKTGHRCLFHPNSGAAGAgalSAVRCGDYKAhyATGGaL 352
|
490 500 510
....*....|....*....|....*....|
gi 1294492365 508 AELGTGTWELY-------NLNNDRGETKNL 530
Cdd:cd16161 353 ACCGSTGPKLYhdppllfDLEVDPAESFPL 382
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
38-535 |
5.21e-41 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 153.50 E-value: 5.21e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 38 KQPNILFIMADDLGySDLGAFGGE-IHTPNLDALTQEGRILTDYHT-APTCSPTRSQLISG---TDHHLAGIGAMAEltp 112
Cdd:cd16030 1 KKPNVLFIAVDDLR-PWLGCYGGHpAKTPNIDRLAARGVLFTNAYCqQPVCGPSRASLLTGrrpDTTGVYDNNSYFR--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 113 ahlKGQPGYegylnersLSIAEVLRDNGYRTYISGK-WHlGLTPETNAHAKGFDHSFTLlQGLDLHFKQAPTAYKRNATY 191
Cdd:cd16030 77 ---KVAPDA--------VTLPQYFKENGYTTAGVGKiFH-PGIPDGDDDPASWDEPPNP-PGPEKYPPGKLCPGKKGGKG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 192 TEDGKQVAISSLPDDFFSTNYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRgvydvgydairnaria 271
Cdd:cd16030 144 GGGGPAWEAADVPDEAYPDGKVADEAIEQLRKLKDSDKPFFLAVGFYKPHLPFVAPKKYFDLYP---------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 272 rqkqlgliPANFTAAEPIATQNAP-QKYGKWNELSAEQKALEARRMEIYAGMVENL---------------DANIGRVIQ 335
Cdd:cd16030 208 --------LESIPLPNPFDPIDLPeVAWNDLDDLPKYGDIPALNPGDPKGPLPDEQarelrqayyasvsyvDAQVGRVLD 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 336 YLKRNHLYDNTLIFFVSDNgaeGFIRGNYGaesgfdnnlnnvgtassyhyvgpRWAEVSaapfhLWkdtagEGATTAPAI 415
Cdd:cd16030 280 ALEELGLADNTIVVLWSDH---GWHLGEHG-----------------------HWGKHT-----LF-----EEATRVPLI 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 416 VKLPNQTQAQAIHHGFASVLDVFPTVLEYANIAVPQgqykgrqiNTpSGYSWKSVLENKAQLIRPAQFS-FADELHGSkY 494
Cdd:cd16030 324 IRAPGVTKPGKVTDALVELVDIYPTLAELAGLPAPP--------CL-EGKSLVPLLKNPSAKWKDAAFSqYPRPSIMG-Y 393
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1294492365 495 A-RQGDWK-IALQGKAELGTGtwELYNLNNDRGETKNLAQDNP 535
Cdd:cd16030 394 SiRTERYRyTEWVDFDKVGAE--ELYDHKNDPNEWKNLANDPE 434
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
37-547 |
6.05e-41 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 154.44 E-value: 6.05e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 37 QKQPNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEG-RILTDYHTAPTCSPTRSQLISGtdhhlagigamaeLTPAH 114
Cdd:PRK13759 4 TKKPNIILIMVDQMRGDCLGCNGNKaVETPNLDMLASEGyNFENAYSAVPSCTPARAALLTG-------------LSQWH 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 115 lKGQPGYE-----GYLNErslsIAEVLRDNGYRTYISGKWHLglTPETNAHakGFDHsfTLLQGLDLHF----------- 178
Cdd:PRK13759 71 -HGRVGYGdvvpwNYKNT----LPQEFRDAGYYTQCIGKMHV--FPQRNLL--GFHN--VLLHDGYLHSgrnedksqfdf 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 179 ---------KQAPtayKRNATYTEDG----KQVA-ISSLPDDFFSTNYFTDKLLSYLESgKNSGKPFFAYAAYTAPHWPI 244
Cdd:PRK13759 140 vsdylawlrEKAP---GKDPDLTDIGwdcnSWVArPWDLEERLHPTNWVGSESIEFLRR-RDPTKPFFLKMSFARPHSPY 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 245 QAPSEYRDRYRgvydvgyDA-IRNARIARQKQlglipanftAAEPIATQNAPQK-YGKwneLSAEQkaleARRMEI-YAG 321
Cdd:PRK13759 216 DPPKRYFDMYK-------DAdIPDPHIGDWEY---------AEDQDPEGGSIDAlRGN---LGEEY----ARRARAaYYG 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 322 MVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGAegfIRGNYgaesgfdnnlnnvgtassyhyvgprwaevsaapfHLW 401
Cdd:PRK13759 273 LITHIDHQIGRFLQALKEFGLLDNTIILFVSDHGD---MLGDH----------------------------------YLF 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 402 KDT-AGEGATTAPAIVKLPNQTQAQAIHHGFASVL---DVFPTVLEYANIAVPqgqykgrqiNTPSGYSWKSVLENKAQL 477
Cdd:PRK13759 316 RKGyPYEGSAHIPFIIYDPGGLLAGNRGTVIDQVVelrDIMPTLLDLAGGTIP---------DDVDGRSLKNLIFGQYEG 386
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1294492365 478 IRPaqfsfadELHG--------SKYARQGDWKIALQgkaeLGTGTWELYNLNNDRGETKNLAQDnpTKVQELIEVYNK 547
Cdd:PRK13759 387 WRP-------YLHGehalgyssDNYLTDGKWKYIWF----SQTGEEQLFDLKKDPHELHNLSPS--EKYQPRLREMRK 451
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
40-533 |
1.22e-39 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 150.10 E-value: 1.22e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFG-GEIHTPNLDALTQEGRILTDYHT-APTCSPTRSQLISGtdHHLAGIGAMAELTPahlkg 117
Cdd:cd16028 1 RNVLFITADQWRADCLSCLGhPLVKTPNLDRLAAEGVRFRNHYTqAAPCGPSRASLYTG--RYLMNHRSVWNGTP----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 qpgyegyLNERSLSIAEVLRDNGYRTYISGKWHLGLTPETnahakgfdhsftlLQGLDLHFKQAPTAykrnatytEDGKQ 197
Cdd:cd16028 74 -------LDARHLTLALELRKAGYDPALFGYTDTSPDPRG-------------LAPLDPRLLSYELA--------MPGFD 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 198 --VAISSLPDDFFSTNYFTDKLLSYLESGKNsgKPFFAYAAYTAPHWPIQAPSEYRDRYRGvyDVGYDAIRNARIARQKQ 275
Cdd:cd16028 126 pvDRLDEYPAEDSDTAFLTDRAIEYLDERQD--EPWFLHLSYIRPHPPFVAPAPYHALYDP--ADVPPPIRAESLAAEAA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 276 LGLIPANFTaaEPIATQNAPQKYGKWNELSAEqkalEARRME-IYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDN 354
Cdd:cd16028 202 QHPLLAAFL--ERIESLSFSPGAANAADLDDE----EVAQMRaTYLGLIAEVDDHLGRLFDYLKETGQWDDTLIVFTSDH 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 355 GaegfirgnygaesgfdnnlnnvgtassyHYVGPRWaevsaapfhLW-KDTAGEGATTAPAIVKLPNQ----TQAQAIhH 429
Cdd:cd16028 276 G----------------------------EQLGDHW---------LWgKDGFFDQAYRVPLIVRDPRReadaTRGQVV-D 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 430 GFASVLDVFPTVLEYANIAVPqgqykgRQINtpsGYSWKSVLEN-KAQLIRPAQFSFAD---------------ELHGSK 493
Cdd:cd16028 318 AFTESVDVMPTILDWLGGEIP------HQCD---GRSLLPLLAGaQPSDWRDAVHYEYDfrdvstrrpqealglSPDECS 388
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1294492365 494 YA--RQGDWK-IALQGKAELgtgtweLYNLNNDRGETKNLAQD 533
Cdd:cd16028 389 LAviRDERWKyVHFAALPPL------LFDLKNDPGELRDLAAD 425
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
39-501 |
6.18e-38 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 145.69 E-value: 6.18e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYSDLGAFGgEIH--TPNLDALTQEGRILTDYHTA-PTCSPTRSQLISG----------TDHHlagig 105
Cdd:cd16157 1 KPNIILMLMDDMGWGDLGVFG-EPSreTPNLDRMAAEGMLFTDFYSAnPLCSPSRAALLTGrlpirngfytTNAH----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 106 AMAELTPAHLKGqpgyeGYLNERSLsIAEVLRDNGYRTYISGKWHLGLTPETNAHAKGFDHSFTllqGLDLHF-----KQ 180
Cdd:cd16157 75 ARNAYTPQNIVG-----GIPDSEIL-LPELLKKAGYRNKIVGKWHLGHRPQYHPLKHGFDEWFG---APNCHFgpydnKA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 181 APT--AYKRN---ATYTED---GKQVAISSLpddffsTNYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRD 252
Cdd:cd16157 146 YPNipVYRDWemiGRYYEEfkiDKKTGESNL------TQIYLQEALEFIEKQHDAQKPFFLYWAPDATHAPVYASKPFLG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 253 RY-RGVYDvgyDAIRnariarqkqlglipanftaaepiatqnapqkygkwnelsaeqkalearrmeiyagmveNLDANIG 331
Cdd:cd16157 220 TSqRGLYG---DAVM----------------------------------------------------------ELDSSVG 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 332 RVIQYLKRNHLYDNTLIFFVSDNGAEGFIRGNYGAESGfdnnlnnvgtassyhyvgprwaevsaaPFHLWKDTAGEGATT 411
Cdd:cd16157 239 KILESLKSLGIENNTFVFFSSDNGAALISAPEQGGSNG---------------------------PFLCGKQTTFEGGMR 291
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 412 APAIVKLPNQTQAQAIHHGFASVLDVFPTVLEYANIAVPqgqyKGRQINtpsGYSWKSVLENKAQLIRPAQFSFADELHG 491
Cdd:cd16157 292 EPAIAWWPGHIKPGQVSHQLGSLMDLFTTSLALAGLPIP----SDRAID---GIDLLPVLLNGKEKDRPIFYYRGDELMA 364
|
490
....*....|
gi 1294492365 492 skyARQGDWK 501
Cdd:cd16157 365 ---VRLGQYK 371
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
40-457 |
1.44e-36 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 136.60 E-value: 1.44e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFG-GEIHTPNLDALTQEGRILTDYHTA-PTCSPTRSQLISGTDHHLAGI------GAMAELT 111
Cdd:cd16149 1 PNILFILTDDQGPWALGCYGnSEAVTPNLDRLAAEGVRFENFFCTsPVCSPARASLLTGRMPSQHGIhdwiveGSHGKTK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 112 PAH--LKGQPGYegylnerslsiAEVLRDNGYRTYISGKWHLGltpetnahakgfdhsftllqgldlhfkqaptaykrna 189
Cdd:cd16149 81 KPEgyLEGQTTL-----------PEVLQDAGYRCGLSGKWHLG------------------------------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 190 tytedgkqvaisslpddffstnyftDKLLSYLESGKNSGKPFFAYAAYTAPHwpiqAPSEYrdryrgvydvgydairnar 269
Cdd:cd16149 113 -------------------------DDAADFLRRRAEAEKPFFLSVNYTAPH----SPWGY------------------- 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 270 iarqkqlglipanFTAAepiatqnapqkygkwnelsaeqkalearrmeiyAGMvenlDANIGRVIQYLKRNHLYDNTLIF 349
Cdd:cd16149 145 -------------FAAV---------------------------------TGV----DRNVGRLLDELEELGLTENTLVI 174
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 350 FVSDNgaeGFIRGNYGAEsGFDNnlnnvGTassyhyvgprWaevsaaPFHLWkdtagEGATTAPAIVKLPNQTQAQAIHH 429
Cdd:cd16149 175 FTSDN---GFNMGHHGIW-GKGN-----GT----------F------PLNMY-----DNSVKVPFIIRWPGVVPAGRVVD 224
|
410 420
....*....|....*....|....*....
gi 1294492365 430 GFASVLDVFPTVLEYANIAVPQGQ-YKGR 457
Cdd:cd16149 225 SLVSAYDFFPTLLELAGVDPPADPrLPGR 253
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
40-550 |
2.44e-36 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 141.43 E-value: 2.44e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGgeiH----TPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGTDHHLAGIgamaelTPAH 114
Cdd:cd16158 2 PNIVLLFADDLGYGDLGCYG---HpsssTPNLDRLAANGLRFTDfYSSSPVCSPSRAALLTGRYQVRSGV------YPGV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 115 LkgQPGYEGYLNERSLSIAEVLRDNGYRTYISGKWHLGLTPE-----TNahaKGFDHSFTLLQGLDLHFKQAPTAYKRNA 189
Cdd:cd16158 73 F--YPGSRGGLPLNETTIAEVLKTVGYQTAMVGKWHLGVGLNgtylpTH---QGFDHYLGIPYSHDQGPCQNLTCFPPNI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 190 TYTEDGKQ----------VAISSLPDDFFSTNYFTDKLL-SYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRY-RGV 257
Cdd:cd16158 148 PCFGGCDQgevpcplfynESIVQQPVDLLTLEERYAKFAkDFIADNAKEGKPFFLYYASHHTHYPQFAGQKFAGRSsRGP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 258 YDvgyDAIrnariarqkqlglipanftaaepiatqnapqkygkwnelsaeqkalearrMEiyagmvenLDANIGRVIQYL 337
Cdd:cd16158 228 FG---DAL--------------------------------------------------AE--------LDGSVGELLQTL 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 338 KRNHLYDNTLIFFVSDNGAEgFIRGNYGAESGfdnnLNNVGTASSYhyvgprwaevsaapfhlwkdtagEGATTAPAIVK 417
Cdd:cd16158 247 KENGIDNNTLVFFTSDNGPS-TMRKSRGGNAG----LLKCGKGTTY-----------------------EGGVREPAIAY 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 418 LPNQTqAQAIHHGFASVLDVFPTVLEYANIAVPQGQYkgrqintpSGYSWKSVLENKAQLIRPAQF---SFADELHGSKY 494
Cdd:cd16158 299 WPGRI-KPGVTHELASTLDILPTIAKLAGAPLPNVTL--------DGVDMSPILFEQGKSPRQTFFyypTSPDPDKGVFA 369
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1294492365 495 ARQGDWKIAL--QGKAELGTG-----------TWE----LYNLNNDRGETKNLAQdNPTKVQELIEVYNKYTQ 550
Cdd:cd16158 370 VRWGKYKAHFytQGAAHSGTTpdkdchpsaelTSHdpplLFDLSQDPSENYNLLG-LPEYNQVLKQIQQVKER 441
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
40-533 |
2.56e-35 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 137.37 E-value: 2.56e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTDYHTA-PTCSPTRSQLISGTDHHLAGIGAMAELTPAHlkg 117
Cdd:cd16150 1 PNIVIFVADQLRADSLGHLGNPaAVTPNLDALAAEGVRFSNAYCQnPVCSPSRCSFLTGWYPHVNGHRTLHHLLRPD--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 QPgyegylnerslSIAEVLRDNGYRTYISGKWHlgltpetnahakgfdhsftllqglDLHFKQAPTAYKrnatyTEDGKQ 197
Cdd:cd16150 78 EP-----------NLLKTLKDAGYHVAWAGKND------------------------DLPGEFAAEAYC-----DSDEAC 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 198 VaisslpddffstnyftDKLLSYLESgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRgvydvgydaiRNARIARQKQLG 277
Cdd:cd16150 118 V----------------RTAIDWLRN-RRPDKPFCLYLPLIFPHPPYGVEEPWFSMID----------REKLPPRRPPGL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 278 LIPANFTAAEPIATQNapqkygkWNELSaeqkalEARRMEI---YAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDN 354
Cdd:cd16150 171 RAKGKPSMLEGIEKQG-------LDRWS------EERWRELratYLGMVSRLDHQFGRLLEALKETGLYDDTAVFFFSDH 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 355 GaeGFIrGNYG-AE---SGFDNNLNNVgtassyhyvgprwaevsaapfhlwkdtagegattaPAIVKLPNQTQAQAIHHg 430
Cdd:cd16150 238 G--DYT-GDYGlVEkwpNTFEDCLTRV-----------------------------------PLIIKPPGGPAGGVSDA- 278
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 431 FASVLDVFPTVLEYANIAVPQGQYkgrqintpsGYSWKSVLENKAQLIRPAQFS---------FADELHGSKYarQGDWK 501
Cdd:cd16150 279 LVELVDIPPTLLDLAGIPLSHTHF---------GRSLLPVLAGETEEHRDAVFSeggrlhgeeQAMEGGHGPY--DLKWP 347
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 1294492365 502 IALQ-------GKA-ELGTGTW----------ELYNLNNDRGETKNLAQD 533
Cdd:cd16150 348 RLLQqeeppehTKAvMIRTRRYkyvyrlyepdELYDLEADPLELHNLIGD 397
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
40-523 |
1.56e-31 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 124.58 E-value: 1.56e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGTDHHLAGIgamaeLTPAHlkg 117
Cdd:cd16037 1 PNILIIMSDEHNPDAMGCYGHPvVRTPNLDRLAARGTRFENaYTPSPICVPSRASFLTGRYVHETGV-----WDNAD--- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 qpgyegYLNERSLSIAEVLRDNGYRTYISGKWHlgltpetnAHAKGFDHSFTllqgldlhfkqaptaYKRNAtytedgkq 197
Cdd:cd16037 73 ------PYDGDVPSWGHALRAAGYETVLIGKLH--------FRGEDQRHGFR---------------YDRDV-------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 198 vaisslpddffstnyfTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRgvydvgydaiRNARIArqkqlg 277
Cdd:cd16037 116 ----------------TEAAVDWLREEAADDKPWFLFVGFVAPHFPLIAPQEFYDLYV----------RRARAA------ 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 278 lipanftaaepiatqnapqkygkwnelsaeqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGae 357
Cdd:cd16037 164 -----------------------------------------YYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSDHG-- 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 358 gfirgnygaesgfDNnlnnvgtassyhyVGPR--WaevsaapfhlWKDTAGEGATTAPAIVKLPNQTQAQAIhHGFASVL 435
Cdd:cd16037 201 -------------DM-------------LGERglW----------GKSTMYEESVRVPMIISGPGIPAGKRV-KTPVSLV 243
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 436 DVFPTVLEYANIAVPQGQykgrqintpSGYSWKSVLENKAQLIRPAqFSfadELH------GSKYARQGDWK-IALQGKA 508
Cdd:cd16037 244 DLAPTILEAAGAPPPPDL---------DGRSLLPLAEGPDDPDRVV-FS---EYHahgspsGAFMLRKGRWKyIYYVGYP 310
|
490
....*....|....*
gi 1294492365 509 ElgtgtwELYNLNND 523
Cdd:cd16037 311 P------QLFDLEND 319
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
39-502 |
1.08e-28 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 118.69 E-value: 1.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYSDLGAFGGEIHTPN-LDALTQEG-RILTDYHTAPTCSPTRSQLISGTDHHLAGI-GAMAELTPAHL 115
Cdd:cd16160 1 KPNIVLFFADDMGYGDLASYGHPTQERGpIDDMAAEGiRFTQAYSADSVCTPSRAALLTGRLPIRSGMyGGTRVFLPWDI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 116 KGQPGYEgylnersLSIAEVLRDNGYRTYISGKWHLGLTPETNA------HAKGFDH-----SFTLLQGLDLHFKQAPTA 184
Cdd:cd16160 81 GGLPKTE-------VTMAEALKEAGYTTGMVGKWHLGINENNHSdgahlpSHHGFDFvgtnlPFTNSWACDDTGRHVDFP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 185 yKRNATYTEDGKQvaISSLPddfFSTNYFTDKLL----SYLESgkNSGKPFFAYAAYTAPHWPIQAPSEYRDR-YRGVYD 259
Cdd:cd16160 154 -DRSACFLYYNDT--IVEQP---IQHEHLTETLVgdakSFIED--NQENPFFLYFSFPQTHTPLFASKRFKGKsKRGRYG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 260 vgyDAIrnariarqkqlglipanftaaepiatqnapqkygkwNELSaeqkalearrmeiYAgmvenldanIGRVIQYLKR 339
Cdd:cd16160 226 ---DNI------------------------------------NEMS-------------WA---------VGEVLDTLVD 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 340 NHLYDNTLIFFVSDNGAEGFIRGNYGAESGFDNnlnnvGTASSYhyvgprwaevsaapfhlwkdtagEGATTAPAIVKLP 419
Cdd:cd16160 245 TGLDQNTLVFFLSDHGPHVEYCLEGGSTGGLKG-----GKGNSW-----------------------EGGIRVPFIAYWP 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 420 NQTQAQaIHHGFASVLDVFPTVLEYANIAVP-QGQYKGRQIntpsgyswKSVL-ENKAQLIRPAQFSFADELHGSKYarq 497
Cdd:cd16160 297 GTIKPR-VSHEVVSTMDIFPTFVDLAGGTLPtDRIYDGLSI--------TDLLlGEADSPHDDILYYCCSRLMAVRY--- 364
|
....*
gi 1294492365 498 GDWKI 502
Cdd:cd16160 365 GSYKI 369
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
40-523 |
1.79e-28 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 116.68 E-value: 1.79e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFG-GEIH--TPNLDALTQEGRILTDYHTAPTCSPTRSQLISGTDHHLAGIgamaeltpahlk 116
Cdd:cd16154 1 PNILLIIADDQGLDSSAQYSlSSDLpvTPTLDSLANSGIVFDNLWATPACSPTRATILTGKYGFRTGV------------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 117 GQPGYEGYLNERSLSIAEVLRDN--GYRTYISGKWHLGLTPETNAHAKGFDHSFTLLQGldlhfkQAPTAYkrNATYTED 194
Cdd:cd16154 69 LAVPDELLLSEETLLQLLIKDATtaGYSSAVIGKWHLGGNDNSPNNPGGIPYYAGILGG------GVQDYY--NWNLTNN 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 195 GKQvaissLPDDFFSTNYFTDKLLSYLEsgkNSGKPFFAYAAYTAPHWPIQAP-SEYRDRYrgvydvgydairnariarq 273
Cdd:cd16154 141 GQT-----TNSTEYATTKLTNLAIDWID---QQTKPWFLWLAYNAPHTPFHLPpAELHSRS------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 274 kqlglipanftaaepiatqnapqkygkwneLSAEQKALEARRMEIYAGMVENLDANIGRVIQYLKRNHLyDNTLIFFVSD 353
Cdd:cd16154 194 ------------------------------LLGDSADIEANPRPYYLAAIEAMDTEIGRLLASIDEEER-ENTIIIFIGD 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 354 NGAEGFIRgnygaesgfdnnlnnvgtassyhyvgPRWAEVSAApfhlwKDTAGEGATTAPAIVKLPNQTQAQAIHHGFAS 433
Cdd:cd16154 243 NGTPGQVV--------------------------DLPYTRNHA-----KGSLYEGGINVPLIVSGAGVERANERESALVN 291
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 434 VLDVFPTVLEYANIAVPqgqykgrQINtpSGYSWKSVLENKAQLIRPAQFSFADELHGSKYARQGDWKIALqgkaELGTG 513
Cdd:cd16154 292 ATDLYATIAELAGVDAA-------EIH--DSVSFKPLLSDVNASTRQYNYTEYESPTTTGWATRNQYYKLI----ESENG 358
|
490
....*....|
gi 1294492365 514 TWELYNLNND 523
Cdd:cd16154 359 QEELYDLIND 368
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
40-451 |
2.66e-26 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 109.59 E-value: 2.66e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGEI-HTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGtdhHLAG-IGAM---AELtPA 113
Cdd:cd16032 1 PNILLIMADQLTAAALPAYGNTVvKTPNLDRLAARGVVFDNaYCNSPLCAPSRASMMTG---RLPSrIGAYdnaAEF-PA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 114 hlkGQPgyegylnerslSIAEVLRDNGYRTYISGKWHLgLTPEtNAHakGFDhsftllqgldlhfkqaptaykrnatYTE 193
Cdd:cd16032 77 ---DIP-----------TFAHYLRAAGYRTALSGKMHF-VGPD-QLH--GFD-------------------------YDE 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 194 DgkqVAisslpddFFSTNYFTDKllsyleSGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYrgvydvgydaIRNARIArq 273
Cdd:cd16032 114 E---VA-------FKAVQKLYDL------ARGEDGRPFFLTVSFTHPHDPYVIPQEYWDLY----------VRRARRA-- 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 274 kqlglipanftaaepiatqnapqkygkwnelsaeqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSD 353
Cdd:cd16032 166 ---------------------------------------------YYGMVSYVDDKVGQLLDTLERTGLADDTIVIFTSD 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 354 NG---AEgfiRGnygaesgfdnnlnnvgtassyhyvgprwaevsaapfhLW-KDTAGEGATTAPAIVKLPNQTQAQAIHH 429
Cdd:cd16032 201 HGdmlGE---RG-------------------------------------LWyKMSFFEGSARVPLIISAPGRFAPRRVAE 240
|
410 420
....*....|....*....|..
gi 1294492365 430 GfASVLDVFPTVLEYANIAVPQ 451
Cdd:cd16032 241 P-VSLVDLLPTLVDLAGGGTAP 261
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
39-451 |
2.99e-26 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 108.23 E-value: 2.99e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYSDLGAFG-----------GEIHTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGtdhhlagiga 106
Cdd:cd16153 1 KPNILWIITDDQRVDSLSCYNnahtgksesrlGYVESPNIDALAAEGVLFTNaYCNSPVCVPSRTSMLTG---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 107 maelTPAHLKGQPGYEGYLN---ERSLSIAEVLRDNGYRTYISGKWHLGltpetnahakgfdhsftllqgldlhfkqAPT 183
Cdd:cd16153 71 ----RYPHRTGVYGFEAAHPaldHGLPTFPEVLKKAGYQTASFGKSHLE----------------------------AFQ 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 184 AYKRNATYTEDGKQVAISSLPDdffstnyftdkllsylesgknSGKPFFAYAAYTAPHWPIQAPSEYRDRYRgvydvgyd 263
Cdd:cd16153 119 RYLKNANQSYKSFWGKIAKGAD---------------------SDKPFFVRLSFLQPHTPVLPPKEFRDRFD-------- 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 264 airnariarqkqlglipanftaaepiatqnapqkygkwnelsaeqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLY 343
Cdd:cd16153 170 -------------------------------------------------------YYAFCAYGDAQVGRAVEAFKAYSLK 194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 344 ---DNTLIFFVSDNGAEgfiRGNYGAESGFdnnlnnvGTASSYHYVgprwaevsaapfhlwkdtagegattaPAIVKLPN 420
Cdd:cd16153 195 qdrDYTIVYVTGDHGWH---LGEQGILAKF-------TFWPQSHRV--------------------------PLIVVSSD 238
|
410 420 430
....*....|....*....|....*....|...
gi 1294492365 421 QTQAQA--IHHGFASVLDVFPTVLEYANIAVPQ 451
Cdd:cd16153 239 KLKAPAgkVRHDFVEFVDLAPTLLAAAGVDVDA 271
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
39-533 |
4.67e-26 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 110.01 E-value: 4.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYSDLGAFGGEIH-TPNLDALTQEGRILTDYHTA-PTCSPTRSQLISG-----TDHHLAGIGamaelt 111
Cdd:cd16152 1 KPNVIVFFTDQQRWDTLGCYGQPLDlTPNLDALAEEGVLFENAFTPqPVCGPARACLQTGlypteTGCFRNGIP------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 112 pahlkgqpgyegyLNERSLSIAEVLRDNGYRT-YIsGKWHLgltpetnahakgfdhsftllqgldlhfkqaptaykrnAT 190
Cdd:cd16152 75 -------------LPADEKTLAHYFRDAGYETgYV-GKWHL-------------------------------------AG 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 191 YTEDgkqvaisslpddffstnYFTDKLLSYLESgKNSGKPFFAYAAYTAPH-----WPIQAPSEYRDRYRGVYdvgydai 265
Cdd:cd16152 104 YRVD-----------------ALTDFAIDYLDN-RQKDKPFFLFLSYLEPHhqndrDRYVAPEGSAERFANFW------- 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 266 rnariarqkqlglIPANFTAAEpiatqnapqkyGKWNELSAEqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLYDN 345
Cdd:cd16152 159 -------------VPPDLAALP-----------GDWAEELPD-----------YLGCCERLDENVGRIRDALKELGLYDN 203
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 346 TLIFFVSDNGAegfirgnygaesgfdnnlnnvgtassyHYVgPRWAEvsaapfhlWKDTAGEGATTAPAIVKLPNQTQAQ 425
Cdd:cd16152 204 TIIVFTSDHGC---------------------------HFR-TRNAE--------YKRSCHESSIRVPLVIYGPGFNGGG 247
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 426 AIHHgFASVLDVFPTVLEYANIAVPqgqykgrqiNTPSGYSWKSVLENKAQLIRPAQFSFADELHGSKYARQGDWKIA-- 503
Cdd:cd16152 248 RVEE-LVSLIDLPPTLLDAAGIDVP---------EEMQGRSLLPLVDGKVEDWRNEVFIQISESQVGRAIRTDRWKYSva 317
|
490 500 510
....*....|....*....|....*....|....*.
gi 1294492365 504 ---LQGKAELGTGT---WELYNLNNDRGETKNLAQD 533
Cdd:cd16152 318 apdKDGWKDSGSDVyveDYLYDLEADPYELVNLIGR 353
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
39-547 |
7.89e-26 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 111.23 E-value: 7.89e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTdYH--TAPTCSPTRSQLI-------SGTDHHLAG----- 103
Cdd:cd16159 1 KPNIVLFMADDLGIGDVGCFGNDtIRTPNIDRLAKEGVKLT-HHlaAAPLCTPSRAAFLtgrypirSGMASSHGMrvilf 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 104 IGAMAELTPahlkgqpgyegylNErsLSIAEVLRDNGYRTYISGKWHLGLtpetNAHAKGFDHSFTLLQGLDlHFKQAPT 183
Cdd:cd16159 80 TASSGGLPP-------------NE--TTFAEVLKQQGYSTALIGKWHLGL----HCESRNDFCHHPLNHGFD-YFYGLPL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 184 AYKRNATyTEDGKQVAISSLPDDFFSTNY---FTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYrgvydv 260
Cdd:cd16159 140 TNLKDCG-DGSNGEYDLSFDPLFPLLTAFvliTALTIFLLLYLGAVSKRFFVFLLILSLLFISLFFLLLITNRY------ 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 261 gYDAI--RNARIARQkqlgliPANFTAAEPIATQNApQKYGKWNE----------------LSAEQKALEARRMEIYAGM 322
Cdd:cd16159 213 -FNCIlmRNHEVVEQ------PMSLENLTQRLTKEA-ISFLERNKerpfllvmsflhvhtaLFTSKKFKGRSKHGRYGDN 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 323 VENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGAEGFIRGNYGAESGFDNNLNNVGtassyhyvgprwaevsaapfhlwK 402
Cdd:cd16159 285 VEEMDWSVGQILDALDELGLKDNTFVYFTSDNGGHLEEISVGGEYGGGNGGIYGGK-----------------------K 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 403 DTAGEGATTAPAIVKLPNQTQAQAIHHGFASVLDVFPTVLEYANIAVPqgqyKGRQINtpsGYSWKSVLENKAQlIRPAQ 482
Cdd:cd16159 342 MGGWEGGIRVPTIVRWPGVIPPGSVIDEPTSLMDIFPTVAALAGAPLP----SDRIID---GRDLMPLLTGQEK-RSPHE 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 483 FSF---ADELHGSKYaRQGD----WKI-----ALQGKAELGTGTW---------------ELYNLNNDRGETKNL-AQDN 534
Cdd:cd16159 414 FLFhycGAELHAVRY-RPRDggavWKAhyftpNFYPGTEGCCGTLlcrcfgdsvthhdppLLFDLSADPSESNPLdPTDE 492
|
570
....*....|...
gi 1294492365 535 PtkVQELIEVYNK 547
Cdd:cd16159 493 P--YQEIIKKILE 503
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
40-533 |
3.93e-25 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 108.62 E-value: 3.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGG-EIHTPNLDALTQEG-RILTDYHTAPTCSPTRSQLISGTDHHLAGIGA--MAeltpahl 115
Cdd:cd16156 1 KQFIFIMTDTQRWDMVGCYGNkAMKTPNLDRLAAEGvRFDSAYTTQPVCGPARSGLFTGLYPHTNGSWTncMA------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 116 kgqpgyegyLNERSLSIAEVLRDNGYRTYISGKWHL--------GLTPEtnahakGFD--HSFTLLQGLDLHFKQAPTAY 185
Cdd:cd16156 74 ---------LGDNVKTIGQRLSDNGIHTAYIGKWHLdggdyfgnGICPQ------GWDpdYWYDMRNYLDELTEEERRKS 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 186 KRNATYTEDgkqvaiSSLPDDFFSTNYFTDKLLSYLEsgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYdvgydai 265
Cdd:cd16156 139 RRGLTSLEA------EGIKEEFTYGHRCTNRALDFIE--KHKDEDFFLVVSYDEPHHPFLCPKPYASMYKDFE------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 266 rnariarqkqLGLIPANFTAAEpiatqNAPQKYGKWNE-LSAEQKALEARRMEIYAGMVENLDANIGRVIQYLKRNhlYD 344
Cdd:cd16156 204 ----------FPKGENAYDDLE-----NKPLHQRLWAGaKPHEDGDKGTIKHPLYFGCNSFVDYEIGRVLDAADEI--AE 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 345 NTLIFFVSDNGaegfirgnygaesgfdnNLNNvgtASSYHYVGPR-WAEVSAAPFHLWkdtagegattAPAIVKLPNQTQ 423
Cdd:cd16156 267 DAWVIYTSDHG-----------------DMLG---AHKLWAKGPAvYDEITNIPLIIR----------GKGGEKAGTVTD 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 424 AQAIHhgfasvLDVFPTVLEYANIAVPQgqykgrqinTPSGYSWKSVLENK-AQLIRPAQFSFA------DELHGSKYAR 496
Cdd:cd16156 317 TPVSH------IDLAPTILDYAGIPQPK---------VLEGESILATIEDPeIPENRGVFVEFGryevdhDGFGGFQPVR 381
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1294492365 497 ---QGDWKIALQgkaeLgTGTWELYNLNNDRGETKNLAQD 533
Cdd:cd16156 382 cvvDGRYKLVIN----L-LSTDELYDLEKDPYEMHNLIDD 416
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
39-531 |
7.63e-24 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 103.78 E-value: 7.63e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 39 QPNILFIMADDLGYsDLGAFGGEIHTPNLdaLTQEGRILTDYHTA-PTCSPTRSQLISG--------TDHHLAGIGAMAE 109
Cdd:cd16147 1 RPNIVLILTDDQDV-ELGSMDPMPKTKKL--LADQGTTFTNAFVTtPLCCPSRASILTGqyahnhgvTNNSPPGGGYPKF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 110 ltpahlkgqpgYEGYLNERSLSIAevLRDNGYRTYISGKwHL---GLTPETNAHAKGFDHSFTLLqgldlhfkqaPTAYK 186
Cdd:cd16147 78 -----------WQNGLERSTLPVW--LQEAGYRTAYAGK-YLngyGVPGGVSYVPPGWDEWDGLV----------GNSTY 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 187 RNATYTEDGKQVAISSLPDDFfSTNYFTDKLLSYLESGKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYDvgydair 266
Cdd:cd16147 134 YNYTLSNGGNGKHGVSYPGDY-LTDVIANKALDFLRRAAADDKPFFLVVAPPAPHGPFTPAPRYANLFPNVTA------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 267 nariarqkqlgliPANFTAAEPIATQNAPqkYGKWNELSAEQkalEARRM-EIYAGMVENL---DANIGRVIQYLKRNHL 342
Cdd:cd16147 206 -------------PPRPPPNNPDVSDKPH--WLRRLPPLNPT---QIAYIdELYRKRLRTLqsvDDLVERLVNTLEATGQ 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 343 YDNTLIFFVSDNGaegfirgnygaesgfdnnlnnvgtassYHyvgprWAEvsaapFHLWKD--TAGEGATTAPAIVKLPN 420
Cdd:cd16147 268 LDNTYIIYTSDNG---------------------------YH-----LGQ-----HRLPPGkrTPYEEDIRVPLLVRGPG 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 421 QTQAQAIHHgFASVLDVFPTVLEYANIAVPqgqykgrqiNTPSGYSWKSVLENKAQLIRpaqfsFADELHGSKYARQgdw 500
Cdd:cd16147 311 IPAGVTVDQ-LVSNIDLAPTILDLAGAPPP---------SDMDGRSCGDSNNNTYKCVR-----TVDDTYNLLYFEW--- 372
|
490 500 510
....*....|....*....|....*....|.
gi 1294492365 501 kialqgkaelGTGTWELYNLNNDRGETKNLA 531
Cdd:cd16147 373 ----------CTGFRELYDLTTDPYQLTNLA 393
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
40-453 |
2.03e-22 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 97.23 E-value: 2.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGE-IHTPNLDALTQEGRILTD-YHTAPTCSPTRSQLISGTDHHLAGIgamaeltpahlkg 117
Cdd:cd16148 1 MNVILIVIDSLRADHLGCYGYDrVTTPNLDRLAAEGVVFDNhYSGSNPTLPSRFSLFTGLYPFYHGV------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 qpgYEGYLNERSLSIAEVLRDNGYRT-YISGKWHLGLTPETNahaKGFDHS-FTLLQGLDLHFKQAPTAYKRnatytedg 195
Cdd:cd16148 68 ---WGGPLEPDDPTLAEILRKAGYYTaAVSSNPHLFGGPGFD---RGFDTFeDFRGQEGDPGEEGDERAERV-------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 196 kqvaisslpddffstnyfTDKLLSYLESGKNSgKPFFAYAAYTAPHWPiqapseYRdryrgvydvgydairnariarqkq 275
Cdd:cd16148 134 ------------------TDRALEWLDRNADD-DPFFLFLHYFDPHEP------YL------------------------ 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 276 lglipanftaaepiatqnapqkygkwnelsaeqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNG 355
Cdd:cd16148 165 -------------------------------------------YDAEVRYVDEQIGRLLDKLKELGLLEDTLVIVTSDHG 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 356 AE----GFIRGNYgaeSGFDNNLNNVgtassyhyvgprwaevsaapfhlwkdtagegattaPAIVKLPNQTQAQAIHHgF 431
Cdd:cd16148 202 EEfgehGLYWGHG---SNLYDEQLHV-----------------------------------PLIIRWPGKEPGKRVDA-L 242
|
410 420
....*....|....*....|....*
gi 1294492365 432 ASVLDVFPTVLEYANIAVP---QGQ 453
Cdd:cd16148 243 VSHIDIAPTLLDLLGVEPPdysDGR 267
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
40-442 |
6.94e-15 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 74.38 E-value: 6.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFGGEI-HTPNLDALTQEGRILTDYHTAPTCS--PTRSQLISGTDHHLAGIGAMAELTPahlk 116
Cdd:cd00016 1 KHVVLIVLDGLGADDLGKAGNPApTTPNLKRLASEGATFNFRSVSPPTSsaPNHAALLTGAYPTLHGYTGNGSADP---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 117 GQPGYEGYLNERSLSIAEVLRDNGYRTYIsgkwhlgltpetnahakgfdhsFTLLQGLDLhfkqaptaykrnatytedgk 196
Cdd:cd00016 77 ELPSRAAGKDEDGPTIPELLKQAGYRTGV----------------------IGLLKAIDE-------------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 197 qvaisslpddffstnyftdkllsylesgKNSGKPFFAYAAYTAPHWPIQAPseyrdryrgvydvgydairnariarqkql 276
Cdd:cd00016 115 ----------------------------TSKEKPFVLFLHFDGPDGPGHAY----------------------------- 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 277 glipanftaaepiatqnapqkygkwnelsaeqkaleARRMEIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGA 356
Cdd:cd00016 138 ------------------------------------GPNTPEYYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHGG 181
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 357 EGFIRGNYGAESgfdnnlnnvGTASSYHYvGPRwaevsaAPFHLWKDTAgegattapaivklpnqtQAQAIHHGFASVLD 436
Cdd:cd00016 182 IDKGHGGDPKAD---------GKADKSHT-GMR------VPFIAYGPGV-----------------KKGGVKHELISQYD 228
|
....*.
gi 1294492365 437 VFPTVL 442
Cdd:cd00016 229 IAPTLA 234
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
40-457 |
7.24e-14 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 72.63 E-value: 7.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLGYSDLGAFG-GEIHTPNLDALTQEGRILTDYHTAPT-CSPTRSQLISGtdHHLAGIGaMAELTPahlkg 117
Cdd:cd16035 1 PNILLILTDQERYPPPWPAGwAALNLPARERLAANGLSFENHYTAACmCSPSRSTLYTG--LHPQQTG-VTDTLG----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 qPGYEGYLNERSLSIAEVLRDNGYRTYISGKWHLgltpetNAHAKGfdhsftllqgldlhfkqaptAYKRNATYTEDgkq 197
Cdd:cd16035 73 -SPMQPLLSPDVPTLGHMLRAAGYYTAYKGKWHL------SGAAGG--------------------GYKRDPGIAAQ--- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 198 vAISslpddffstnyftdkLLSYLESGKNSGKPFFAYAAYTAPH---WPIQAPSEYRDRyrgvydvgydairnariarqk 274
Cdd:cd16035 123 -AVE---------------WLRERGAKNADGKPWFLVVSLVNPHdimFPPDDEERWRRF--------------------- 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 275 qlglipANFtaaepiatqnapqkygkwnelsaeqkalearrmeiYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSDN 354
Cdd:cd16035 166 ------RNF-----------------------------------YYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSDH 204
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 355 G----AEGFIRGNYGAesgFDNNLNnvgtassyhyvgprwaevsaAPFHLwkdtagegatTAPAIVKLPNQTQAqaihhg 430
Cdd:cd16035 205 GemggAHGLRGKGFNA---YEEALH--------------------VPLII----------SHPDLFGTGQTTDA------ 245
|
410 420
....*....|....*....|....*..
gi 1294492365 431 FASVLDVFPTVLEYANIAVPQGQYKGR 457
Cdd:cd16035 246 LTSHIDLLPTLLGLAGVDAEARATEAP 272
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
17-457 |
1.40e-11 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 66.99 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 17 LSISACNDSDSNESNGSvGTQKQPNILFIMADDLGYSDLGAFGGEIH-TPNLDALTQEGrILTDYHTAPTCSPTRSQLIS 95
Cdd:COG1368 213 LEIKKYLKSNRPTPNPF-GPAKKPNVVVILLESFSDFFIGALGNGKDvTPFLDSLAKES-LYFGNFYSQGGRTSRGEFAV 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 96 gtdhhLAGIGAMAELTPAHLKGQPGYEgylnerslSIAEVLRDNGYRTyisgkwhlgltpetnahakgfdhSFtlLQGLD 175
Cdd:COG1368 291 -----LTGLPPLPGGSPYKRPGQNNFP--------SLPSILKKQGYET-----------------------SF--FHGGD 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 176 LHFkqaptaYKRNATYTEDG--KQVAISSLPDDFFST-----NYFTDKLLSYLesgKNSGKPFFAYAAYTAPHWPiqaps 248
Cdd:COG1368 333 GSF------WNRDSFYKNLGfdEFYDREDFDDPFDGGwgvsdEDLFDKALEEL---EKLKKPFFAFLITLSNHGP----- 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 249 eyrdryrgvYDVgydairnariarqkqlglipanftaaepiatqnaPQKYGKWNELSAEQKALearrmeiYAGMVENLDA 328
Cdd:COG1368 399 ---------YTL----------------------------------PEEDKKIPDYGKTTLNN-------YLNAVRYADQ 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 329 NIGRVIQYLKRNHLYDNTLIFFVSDNGaegfirGNYGAESGFDNNLNNVGTassyhyvgprwaevsaapfhlwkdtageg 408
Cdd:COG1368 429 ALGEFIEKLKKSGWYDNTIFVIYGDHG------PRSPGKTDYENPLERYRV----------------------------- 473
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1294492365 409 attaPAIVKLPNQTQAQAIHHgFASVLDVFPTVLEYANIAVPQGQYKGR 457
Cdd:COG1368 474 ----PLLIYSPGLKKPKVIDT-VGSQIDIAPTLLDLLGIDYPSYYAFGR 517
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
40-446 |
1.22e-09 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 59.62 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDLG--YSDLGAFGGEIhTPNLDALTQEGRILTDYHTAPTCSPT-RSQLISgtdhhLAGIgamaeltPAHLK 116
Cdd:cd16015 1 PNVIVILLESFSdpYIDKDVGGEDL-TPNLNKLAKEGLYFGNFYSPGFGGGTaNGEFEV-----LTGL-------PPLPL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 117 GQPGYEGYLNERSLSIAEVLRDNGYRTYIsgkWHlgltpetnahakGFDHSFtllqgldlhfkqaptaYKRNATYTEDG- 195
Cdd:cd16015 68 GSGSYTLYKLNPLPSLPSILKEQGYETIF---IH------------GGDASF----------------YNRDSVYPNLGf 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 196 -KQVAISSLPDDFFSTN-------YFTDKLLSYLEsgKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYDvgydairn 267
Cdd:cd16015 117 dEFYDLEDFPDDEKETNgwgvsdeSLFDQALEELE--ELKKKPFFIFLVTMSNHGPYDLPEEKKDEPLKVEE-------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 268 ariarqkqlglipanftaaepiatqnapqkygkwnelsaeqkalEARRMEIYAGMVENLDANIGRVIQYLKRNHLYDNTL 347
Cdd:cd16015 187 --------------------------------------------DKTELENYLNAIHYTDKALGEFIEKLKKSGLYENTI 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 348 IFFVSDNGAegFIRGNYGAESGFDNNLNNVgtassyhyvgprwaevsaaPFHLWkdtagegattAPAIVKlpnqtqaQAI 427
Cdd:cd16015 223 IVIYGDHLP--SLGSDYDETDEDPLDLYRT-------------------PLLIY----------SPGLKK-------PKK 264
|
410
....*....|....*....
gi 1294492365 428 HHGFASVLDVFPTVLEYAN 446
Cdd:cd16015 265 IDRVGSQIDIAPTLLDLLG 283
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
40-501 |
2.39e-08 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 56.01 E-value: 2.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 40 PNILFIMADDL-GYSDLGAFGGEIHTPNLDALTQEGRI-LTDYHTAPTCSPTRSQLISGTDHHLAgigamaeltpahlKG 117
Cdd:cd16171 1 PNVVMVMSDSFdGRLTFRPGNQVVDLPYINFMKQHGSVfLNAYTNSPICCPSRAAMWSGLFTHLT-------------ES 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 118 QPGYEGyLNERSLSIAEVLRDNGYRTYISGK--WHLGLTPETN-AHAKGFDHSFTLLQgldlhfKQAPTAykrnaTYTED 194
Cdd:cd16171 68 WNNYKG-LDPNYPTWMDRLEKHGYHTQKYGKldYTSGHHSVSNrVEAWTRDVPFLLRQ------EGRPTV-----NLVGD 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 195 GKQVAISSLpdDFFSTnyftDKLLSYL-ESGKNSGKPFFAYAAYTAPHwPIQAPSEYRDryrgvydvgYDAIRNARiarq 273
Cdd:cd16171 136 RSTVRVMLK--DWQNT----DKAVHWIrKEAPNLTQPFALYLGLNLPH-PYPSPSMGEN---------FGSIRNIR---- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 274 kqlglipanftaaepiatqnapqkygkwnelsaeqkalearrmEIYAGMVENLDANIGRVIQYLKRNHLYDNTLIFFVSD 353
Cdd:cd16171 196 -------------------------------------------AFYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSD 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 354 NGaegfirgnygaesgfdnnlnnvgtassyhyvgprwaEVSAAPFHLWKDTAGEGATTAPAIVKLPNQTQAQAIHHgFAS 433
Cdd:cd16171 233 HG------------------------------------ELAMEHRQFYKMSMYEGSSHVPLLIMGPGIKAGQQVSD-VVS 275
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1294492365 434 VLDVFPTVLEYANIAVPQGQykgrqintpSGYSWKSVLENKAQLIRPAQFSFAD----ELHG-----SKYA-RQGDWK 501
Cdd:cd16171 276 LVDIYPTMLDIAGVPQPQNL---------SGYSLLPLLSESSIKESPSRVPHPDwvlsEFHGcnvnaSTYMlRTNSWK 344
|
|
| DUF4994 |
pfam16385 |
Domain of unknown function; This family around 100 residues locates in the C-terminal of some ... |
496-541 |
2.45e-06 |
|
Domain of unknown function; This family around 100 residues locates in the C-terminal of some uncharacterized proteins in various Bacteroides and Prevotella species. The function of this family remains unknown.
Pssm-ID: 406720 [Multi-domain] Cd Length: 98 Bit Score: 46.13 E-value: 2.45e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1294492365 496 RQGDWK---------IALQGKAELG-TGTWELYNLNNDRGETKNLAQDNPTKVQEL 541
Cdd:pfam16385 39 RTGDWKyiepsdgpaYIKWTKIETGnSPEPQLYDLKADPGEQENVAKKHPEKVKEL 94
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
224-356 |
2.78e-05 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 46.26 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 224 GKNSGKPFFAYAAYTAPHWPIQAPSEYRDRYRGVYDV---GYDAIRNARIARQKQLGLI-PANFTAAEPIATQNAPQKYG 299
Cdd:pfam01663 102 GVRAAALFWPGSEVDYSTYYGTPPRYLKDDYNNSVPFedrVDTAVLQTWLDLPFADVAAeRPDLLLVYLEEPDYAGHRYG 181
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1294492365 300 KWNELSAEQkalearrmeiyagmVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNGA 356
Cdd:pfam01663 182 PDSPEVEDA--------------LRRVDRAIGDLLEALDERGLFEDTNVIVVSDHGM 224
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
37-191 |
4.42e-04 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 42.81 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 37 QKQPNILFIMADDLGYSDLGAFggeiHTPNLDALTQEGRILTDYHTA-PTCSPTrSQ--LISGT--DHHlaGI------- 104
Cdd:COG1524 21 PPAKKVVLILVDGLRADLLERA----HAPNLAALAARGVYARPLTSVfPSTTAP-AHttLLTGLypGEH--GIvgngwyd 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1294492365 105 GAMAELTPAHLKGQPGYEGYLNERSLSIAEVLRDNGYRTYISGKWHLGLTPETNAHA-KGFDHSFTLLQGLD------LH 177
Cdd:COG1524 94 PELGRVVNSLSWVEDGFGSNSLLPVPTIFERARAAGLTTAAVFWPSFEGSGLIDAARpYPYDGRKPLLGNPAadrwiaAA 173
|
170
....*....|....
gi 1294492365 178 FKQAPTAYKRNATY 191
Cdd:COG1524 174 ALELLREGRPDLLL 187
|
|
| Enpp |
cd16018 |
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
322-355 |
3.79e-03 |
|
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.
Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 39.49 E-value: 3.79e-03
10 20 30
....*....|....*....|....*....|....
gi 1294492365 322 MVENLDANIGRVIQYLKRNHLYDNTLIFFVSDNG 355
Cdd:cd16018 184 ALKRVDRRLGYLIEALKERGLLDDTNIIVVSDHG 217
|
|
| |
