glutamate mutase L is encoded by glmL, which is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase; may play a role in glutamate fermentation
conserved hypothetical protein; This small family includes, so far, an uncharacterized protein ...
3-460
0e+00
conserved hypothetical protein; This small family includes, so far, an uncharacterized protein from E. coli O157:H7 and GlmL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family (pfam01968).
The actual alignment was detected with superfamily member NF040745:
Pssm-ID: 480543 Cd Length: 460 Bit Score: 698.88 E-value: 0e+00
methylaspartate mutase accessory protein GlmL; GlmL (glutamate mutase operon protein L), a ...
3-460
0e+00
methylaspartate mutase accessory protein GlmL; GlmL (glutamate mutase operon protein L), a protein with unknown activity, occurs invariably as part of a locus that also includes the E (epsilon) and S (sigma) subunits of methylaspartate mutase (also called glutamate mutase. A related protein occurs exclusively in a locus the anaerobic degradation of ornithine, where a different cobalamin-dependent enzyme occurs. It seems likely that GlmL is an accessory protein for the methylaspartate mutase.
Pssm-ID: 468709 Cd Length: 460 Bit Score: 698.88 E-value: 0e+00
MutL protein; This small family includes, GlmL/MutL from Clostridium tetanomorphum and ...
3-458
0e+00
MutL protein; This small family includes, GlmL/MutL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family.
Pssm-ID: 433594 Cd Length: 448 Bit Score: 552.15 E-value: 0e+00
conserved hypothetical protein; This small family includes, so far, an uncharacterized protein ...
6-459
3.92e-117
conserved hypothetical protein; This small family includes, so far, an uncharacterized protein from E. coli O157:H7 and GlmL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family (pfam01968).
Pssm-ID: 130386 Cd Length: 463 Bit Score: 351.26 E-value: 3.92e-117
methylaspartate mutase accessory protein GlmL; GlmL (glutamate mutase operon protein L), a ...
3-460
0e+00
methylaspartate mutase accessory protein GlmL; GlmL (glutamate mutase operon protein L), a protein with unknown activity, occurs invariably as part of a locus that also includes the E (epsilon) and S (sigma) subunits of methylaspartate mutase (also called glutamate mutase. A related protein occurs exclusively in a locus the anaerobic degradation of ornithine, where a different cobalamin-dependent enzyme occurs. It seems likely that GlmL is an accessory protein for the methylaspartate mutase.
Pssm-ID: 468709 Cd Length: 460 Bit Score: 698.88 E-value: 0e+00
MutL protein; This small family includes, GlmL/MutL from Clostridium tetanomorphum and ...
3-458
0e+00
MutL protein; This small family includes, GlmL/MutL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family.
Pssm-ID: 433594 Cd Length: 448 Bit Score: 552.15 E-value: 0e+00
conserved hypothetical protein; This small family includes, so far, an uncharacterized protein ...
6-459
3.92e-117
conserved hypothetical protein; This small family includes, so far, an uncharacterized protein from E. coli O157:H7 and GlmL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family (pfam01968).
Pssm-ID: 130386 Cd Length: 463 Bit Score: 351.26 E-value: 3.92e-117
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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