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Conserved domains on  [gi|1215509771|gb|ASK92564|]
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hypothetical protein XcvCFBP7111P_14645 [Xanthomonas citri pv. vignicola]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130261)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Bacillus subtilis phosphatidylglycerophosphatase B that catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0016020|GO:0016791|GO:1901137|GO:0006629
PubMed:  9122162
SCOP:  3001110

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 41-218 6.41e-50

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


:

Pssm-ID: 239486  Cd Length: 182  Bit Score: 161.62  E-value: 6.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  41 ADEVHALENVYFDEPLLWSMRSIATPALDAFFGAISKVGYQYGVIPADIAIALVLLVLQRWREGTFAALGFGGSALLNMG 120
Cdd:cd03392     1 AVVVQAGWLTAFDQSVLSLLRSLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGGALNTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 121 AKQFFQRDRPSLWESIaPESTFSFPSGHAMGSMTLAAVVIALAW----STRWRWPVTIVASLFALLVGISRIYLGVHYPS 196
Cdd:cd03392    81 LKLLVQRPRPPLHLLV-PEGGYSFPSGHAMGATVLYGFLAYLLArrlpRRRVRILLLILAAILILLVGLSRLYLGVHYPS 159

                         170       180
                  ....*....|....*....|..
gi 1215509771 197 DILGGWSAALVWVVGLYLVMFR 218
Cdd:cd03392   160 DVLAGWLLGLAWLALLILLYRR 181
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 41-218 6.41e-50

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 161.62  E-value: 6.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  41 ADEVHALENVYFDEPLLWSMRSIATPALDAFFGAISKVGYQYGVIPADIAIALVLLVLQRWREGTFAALGFGGSALLNMG 120
Cdd:cd03392     1 AVVVQAGWLTAFDQSVLSLLRSLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGGALNTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 121 AKQFFQRDRPSLWESIaPESTFSFPSGHAMGSMTLAAVVIALAW----STRWRWPVTIVASLFALLVGISRIYLGVHYPS 196
Cdd:cd03392    81 LKLLVQRPRPPLHLLV-PEGGYSFPSGHAMGATVLYGFLAYLLArrlpRRRVRILLLILAAILILLVGLSRLYLGVHYPS 159

                         170       180
                  ....*....|....*....|..
gi 1215509771 197 DILGGWSAALVWVVGLYLVMFR 218
Cdd:cd03392   160 DVLAGWLLGLAWLALLILLYRR 181
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 30-218 8.71e-21

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 86.25  E-value: 8.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  30 VLLPLGLFVDLADEVHALENVYFDEPLLWSMRSIATPALDAFFGAISKVGYQYGVIPADIAIALVLLVLQRWREGTFAAL 109
Cdd:COG0671     1 LLLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 110 GFGGSALLNMGAKQFFQRDRP----SLWESIAPESTFSFPSGHAMGSMTLAAVVIALAWstrwRWPVTIVASLFALLVGI 185
Cdd:COG0671    81 LLLLLLLLLLLLKYLFGRPRPfvvpDLELLLGTAGGYSFPSGHAAAAFALALVLALLLP----RRWLAALLLALALLVGL 156

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1215509771 186 SRIYLGVHYPSDILGGWSAALVWVVGLYLVMFR 218
Cdd:COG0671   157 SRVYLGVHYPSDVLAGALLGLAIALLLLALLRR 189
acidPPc smart00014
Acid phosphatase homologues;
108-209 3.00e-15

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 69.68  E-value: 3.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  108 ALGFGGSALLNMGAKQFFQRDRPSLWESIAP----------ESTFSFPSGHAMGSMTLAAVViALAWSTRWRWPVTIVAS 177
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDAcctpnflltlEAGYSFPSGHTAFAFAFALFL-LLYLPARAGRKLLIFLL 79

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1215509771  178 L-FALLVGISRIYLGVHYPSDILGGWSAALVWV 209
Cdd:smart00014  80 LlLALVVGFSRVYLGAHWPSDVLAGSLLGILIA 112
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 107-218 4.78e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 69.37  E-value: 4.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 107 AALGFGGSALLNMGAKQFFQRDRPSLW---------ESIAPESTFSFPSGHAMGSMTLAAVVIALAWSTRWRWPV--TIV 175
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLllegglvpaPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVllALL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1215509771 176 ASLFALLVGISRIYLGVHYPSDILGGWSAALVWVVGLYLVMFR 218
Cdd:pfam01569  82 LLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 139-209 2.51e-08

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 53.11  E-value: 2.51e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215509771 139 ESTFSFPSGHAMGSMTLAAVVIALAWsTRWRWPVTIVASLFALLVGISRIYLGVHYPSDILGG--WSAALVWV 209
Cdd:PRK10699  154 ETGFAFPSGHTMFAASWALLAVGLLW-PRRRYKTVALLMLWATGVMGSRLLLGMHWPRDLVVAtlISWLLVTV 225
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 41-218 6.41e-50

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 161.62  E-value: 6.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  41 ADEVHALENVYFDEPLLWSMRSIATPALDAFFGAISKVGYQYGVIPADIAIALVLLVLQRWREGTFAALGFGGSALLNMG 120
Cdd:cd03392     1 AVVVQAGWLTAFDQSVLSLLRSLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGGALNTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 121 AKQFFQRDRPSLWESIaPESTFSFPSGHAMGSMTLAAVVIALAW----STRWRWPVTIVASLFALLVGISRIYLGVHYPS 196
Cdd:cd03392    81 LKLLVQRPRPPLHLLV-PEGGYSFPSGHAMGATVLYGFLAYLLArrlpRRRVRILLLILAAILILLVGLSRLYLGVHYPS 159

                         170       180
                  ....*....|....*....|..
gi 1215509771 197 DILGGWSAALVWVVGLYLVMFR 218
Cdd:cd03392   160 DVLAGWLLGLAWLALLILLYRR 181
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 100-213 1.31e-21

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 86.75  E-value: 1.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 100 RWREGTFAALGFGGSALLNMGAKQFFQRDRPSLWE--------SIAPESTFSFPSGHAMGSMTLAAVVIALAWSTRWRWP 171
Cdd:cd01610     1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLrcgpdgdpLLLTEGGYSFPSGHAAFAFALALFLALLLPRRLLRLL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1215509771 172 VTIVASLFALLVGISRIYLGVHYPSDILGGWSAALVWVVGLY 213
Cdd:cd01610    81 LGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 30-218 8.71e-21

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 86.25  E-value: 8.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  30 VLLPLGLFVDLADEVHALENVYFDEPLLWSMRSIATPALDAFFGAISKVGYQYGVIPADIAIALVLLVLQRWREGTFAAL 109
Cdd:COG0671     1 LLLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 110 GFGGSALLNMGAKQFFQRDRP----SLWESIAPESTFSFPSGHAMGSMTLAAVVIALAWstrwRWPVTIVASLFALLVGI 185
Cdd:COG0671    81 LLLLLLLLLLLLKYLFGRPRPfvvpDLELLLGTAGGYSFPSGHAAAAFALALVLALLLP----RRWLAALLLALALLVGL 156

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1215509771 186 SRIYLGVHYPSDILGGWSAALVWVVGLYLVMFR 218
Cdd:COG0671   157 SRVYLGVHYPSDVLAGALLGLAIALLLLALLRR 189
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 56-215 1.97e-17

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 76.92  E-value: 1.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  56 LLWSMRSIATPALDAFFGAISKVGYQygvIPADIAIALVLLVL---QRWREGTFAALGFGGSALLNMGA-KQFFQRDRPS 131
Cdd:cd03395    10 FLLLNGTLVHPLLDDLMPFLTGKKLS---VPIFLLLALFILFRkgpIGLLILLLVLLAVGFADQLASGFlKPLVARLRPC 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 132 -------LWESIAPESTFSFPSGHAMGSMTLAAVVIALAWSTRWRWPVTivasLFALLVGISRIYLGVHYPSDILGGWSA 204
Cdd:cd03395    87 naldgvrLVVLGDQGGSYSFASSHAANSFALALFIWLFFRRGLFSPVLL----LWALLVGYSRVYVGVHYPGDVIAGALI 162

                         170
                  ....*....|.
gi 1215509771 205 ALVWVVGLYLV 215
Cdd:cd03395   163 GIISGLLFYLL 173
acidPPc smart00014
Acid phosphatase homologues;
108-209 3.00e-15

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 69.68  E-value: 3.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  108 ALGFGGSALLNMGAKQFFQRDRPSLWESIAP----------ESTFSFPSGHAMGSMTLAAVViALAWSTRWRWPVTIVAS 177
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDAcctpnflltlEAGYSFPSGHTAFAFAFALFL-LLYLPARAGRKLLIFLL 79

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1215509771  178 L-FALLVGISRIYLGVHYPSDILGGWSAALVWV 209
Cdd:smart00014  80 LlLALVVGFSRVYLGAHWPSDVLAGSLLGILIA 112
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 107-218 4.78e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 69.37  E-value: 4.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 107 AALGFGGSALLNMGAKQFFQRDRPSLW---------ESIAPESTFSFPSGHAMGSMTLAAVVIALAWSTRWRWPV--TIV 175
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLllegglvpaPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVllALL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1215509771 176 ASLFALLVGISRIYLGVHYPSDILGGWSAALVWVVGLYLVMFR 218
Cdd:pfam01569  82 LLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 102-210 4.01e-12

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 61.62  E-value: 4.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 102 REGTFAALGFGGSALLNMGAKQFFQRDRPSLWESI-----APESTFSFPSGHAMGSMTLAAVVIALawsTRWRWpVTIVA 176
Cdd:cd03393    13 RLGRYLGLALCASGYLNAALKEVFKIPRPFTYDGIqaiyeESAGGYGFPSGHAQTSATFWGSLMLH---VRKKW-FTLIG 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1215509771 177 SLFALLVGISRIYLGVHYPSDILGGWSAALVWVV 210
Cdd:cd03393    89 VVLVVLISFSRLYLGVHWPSDVIGGVLIGLLVLV 122
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 41-201 7.29e-11

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 59.75  E-value: 7.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  41 ADEVHALENVYFDEPLLWSMRSIATPALDAFFGAISKVGYQYGVIpADIAIALVLLVLQRWREgTFAALGFGGSALLN-- 118
Cdd:cd03380    32 AAYAADLAEVKALGALQSTARTTAQTALAAFDADGGDPPPHYANA-FSIALGTPGLSEERTPR-LYALLARALTDAGIat 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 119 MGAKQFFQRDRP-----SLWESIAPESTF-----SFPSGHAMGSMTlAAVVIALAWSTRWrwpvtivASLFAL--LVGIS 186
Cdd:cd03380   110 WDAKYHYNRPRPfvairLQWLPICTPEEGtpkhpSYPSGHATFGGA-AALVLAELFPERA-------AELLARaaEAGNS 181

                         170
                  ....*....|....*
gi 1215509771 187 RIYLGVHYPSDILGG 201
Cdd:cd03380   182 RVVAGVHWPSDVEAG 196
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 50-216 1.88e-10

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 58.10  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  50 VYFDEPLLWSMRSIATPALDAFFGAISKVGYQYGVIPADIAIALVLLVLQ--------RWREGTFAALGF------GGSA 115
Cdd:cd03389     3 FYLDRPLALYIKALDGRILAGFFRTITDFGKSGWYLIPSLLLFLLFRFGDlrglsapsRARFPKAAWAGLflfatvALSG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 116 LLNMGAKQFFQRDRPSLWESI---------APESTFSFPSGHamgSMTLAAVVIALAW-STRWRWPvtivASLFALLVGI 185
Cdd:cd03389    83 ILVNLLKFIIGRARPKLLFDDglygfdpfhADYAFTSFPSGH---SATAGAAAAALALlFPRYRWA----FILLALLIAF 155

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1215509771 186 SRIYLGVHYPSDILGGWSAALVWVVGLYLVM 216
Cdd:cd03389   156 SRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
COG3907 COG3907
Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction ...
 76-224 7.93e-10

Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction only];


Pssm-ID: 443113  Cd Length: 236  Bit Score: 57.21  E-value: 7.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  76 SKVGYQYGVIPAdIAIALVLLVL-----------QRWREGTFAALGFGGSALLNMGAKQFFQRDRP-------------S 131
Cdd:COG3907    60 ELLLHDGGKWLV-ILVAVLLLLLllasfkrprlrRYRRRLLYLLLSLALGLLVVSLLKSHTGRPCPwdlvefggdapyvP 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 132 LWESIAPESTF--SFPSGHA-MGSMTLAAVVIALAWSTRWRWPVTIVASLFALLVGISRIYLGVHYPSDILggWSAALVW 208
Cdd:COG3907   139 LFEPGPAGAGPgrCFPAGHAsAGFALLALYFLLRRRRPRLARLGLAAGLALGLLMGLAQMLRGAHFLSHTL--WSAWICW 216

                         170
                  ....*....|....*...
gi 1215509771 209 VV--GLYLVMFRGARRPH 224
Cdd:COG3907   217 LValLLYWLLLRRPALEA 234
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 101-215 9.77e-10

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 54.26  E-value: 9.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 101 WREGTFAALGFGGSALLNMGAKQFFQRDRPSlwesIAPESTFSFPSGHAMGSMTLAAvviALAWSTRWRWPvTIVASLFA 180
Cdd:cd03394     2 REGLLILAEAAALTAAVTEGLKFAVGRARPD----GSNNGYRSFPSGHTASAFAAAT---FLQYRYGWRWY-GIPAYALA 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1215509771 181 LLVGISRIYLGVHYPSDILGGwsAALVWVVGLYLV 215
Cdd:cd03394    74 SLVGASRVVANRHWLSDVLAG--AAIGILVGYLVT 106
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 90-213 1.17e-09

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 54.96  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  90 AIALVLLVLQRWRE------GTFAALGFGGSALLNMGAKQFFQRDRP------SLWESIAPEStfSFPSGHAMgsmTLAA 157
Cdd:cd03385    15 ILPLLLVVLWLWGGekqrkvVLFATIAVAVALLINYIIGLLYFHPRPfvvglgHNLLPHAADS--SFPSDHTT---LFFS 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1215509771 158 VVIALAWSTRWRWPVTIVasLFALLVGISRIYLGVHYPSDILGGWSAALVWVVGLY 213
Cdd:cd03385    90 IAFSLLLRRRKWAGWILL--ILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLVF 143
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 139-209 2.51e-08

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 53.11  E-value: 2.51e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215509771 139 ESTFSFPSGHAMGSMTLAAVVIALAWsTRWRWPVTIVASLFALLVGISRIYLGVHYPSDILGG--WSAALVWV 209
Cdd:PRK10699  154 ETGFAFPSGHTMFAASWALLAVGLLW-PRRRYKTVALLMLWATGVMGSRLLLGMHWPRDLVVAtlISWLLVTV 225
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 119-201 1.76e-07

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 50.41  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 119 MGAKQFFQRDRPSLW--ESI-------APESTFSFPSGHAMGSMTLAavvIALAwstrwrwpvTIVASLFALLV------ 183
Cdd:cd03397   118 YPAKKYYNRPRPFVLndEPIctppdesGLAKDGSYPSGHTAAGYAWA---LILA---------ELVPERADEILargsey 185

                          90
                  ....*....|....*...
gi 1215509771 184 GISRIYLGVHYPSDILGG 201
Cdd:cd03397   186 GQSRIVCGVHWPSDVMGG 203
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 142-201 8.23e-07

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 47.22  E-value: 8.23e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215509771 142 FSFPSGHAMGSMTLAAVVIALAWStRWRWPV---TIVASLFALLVGISRIYLGVHYPSDILGG 201
Cdd:cd03388    78 YGFPSTHAMNATAISFYLLIYLYD-RYQYPFvlgLILALFYSTLVCLSRIYMGMHSVLDVIAG 139
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 120-201 1.23e-06

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 46.93  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 120 GAKQFFQRDRP-----SLWESIAPEsTFSFPSGHAMGSMTLAAVVIALAWSTRwrwPVTIVASLFALLVGISRIYLGVHY 194
Cdd:cd03391    65 ILKALVRRRRPaynspDMLDYVAVD-KYSFPSGHASRAAFVARFLLNHLVLAV---PLRVLLVLWATVVGISRVLLGRHH 140


                  ....*..
gi 1215509771 195 PSDILGG 201
Cdd:cd03391   141 VLDVLAG 147
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 106-212 5.56e-06

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 45.75  E-value: 5.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 106 FAALGFGGSALLNMGAKQFFQRDRP-------------SLWESIAPESTF--SFPSGHAMGsmtlAAVVIALAW-----S 165
Cdd:cd03396    71 LLILVIGLGLLVVAILKSHWGRPRPwdltefggdapytPLFSGPSNGCGKgcSFPSGHASA----GFALLALYFlfrrrR 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1215509771 166 TRWRWPVTIVASLFALLVGISRIYLGVHYPSDILggWSAALVWVVGL 212
Cdd:cd03396   147 PRLARLVLAAGLALGALMGLARMARGAHFLSDVL--WSLLLVWLIAL 191
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 75-204 7.31e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 41.88  E-value: 7.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  75 ISKVGYQYGVIPadIAIALVLLVLQRWREGTFAALGFGG---SALLNMGAKQFFQRDRPSLWESIAPeSTFSFPSGHA-- 149
Cdd:cd03382    14 LSFLLAYLSLLP--VAILVGYATLILFRRELEAIYLFIGllaNEALNYVLKRIIKEPRPCSGAYFVR-SGYGMPSSHSqf 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 150 MGSMTLAAVVIALAW-----STRWRWPVTIVASLFALLVGISRIYLGVHYPSDILGGWSA 204
Cdd:cd03382    91 MGFFAVYLLLFIYLRlgrlnSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 84-202 7.89e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 42.21  E-value: 7.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  84 VIPAdIAIALVLLVLQRWREGTFAA-LGFGGSALLNMGA----KQFFQRDRPSL------------------------WE 134
Cdd:cd03390    24 GIPL-LVIILISLFFRRSLWDLHTSlLGLLLSVSLNGVItnvlKNYAGRPRPDFlarcfpdggtpsdtlvgidicctgDP 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1215509771 135 SIAPESTFSFPSGH---AMGSMTLAAVVIA---LAWSTR---WRWPVTIVASLFALLVGISRIYLGVHYPSDILGGW 202
Cdd:cd03390   103 GVLKEGRKSFPSGHssfAFAGLGFLSLYLAgklHIFDPRgssWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGS 179
PAP2_3 pfam14378
PAP2 superfamily;
143-207 8.80e-05

PAP2 superfamily;


Pssm-ID: 433919  Cd Length: 190  Bit Score: 41.94  E-value: 8.80e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1215509771 143 SFPSGHAMGSMTLAAVVialaWSTRWRWPVTIVASLFALLVGISRIYLGVHYPSDILGGWSAALV 207
Cdd:pfam14378 126 AMPSLHVAWALLCALAL----WRLRRTRILRWLAVAYNVLMIVSTVATGNHYLLDVVAGVALALA 186
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 139-202 8.86e-05

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 41.46  E-value: 8.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1215509771 139 ESTFSFPSGHAMGSMtLAAVVIALAWSTRWRWPVTIVAS--------LFALLVGISRIYLGVHYPSDILGGW 202
Cdd:cd03384    69 EARLSFPSGHASLSM-YAAVFLALYLQARLKLRGSRLLRpllqflllALALYVGLSRISDYKHHWSDVLAGA 139
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 137-207 1.12e-04

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 41.92  E-value: 1.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1215509771 137 APEStfSFPSGHAMGSMTLAavVIALAWSTRWrwpVTIVASLFALLVGISRIYLGVHYPSDILGGWSAALV 207
Cdd:PRK11837  100 AADD--SFPSDHGTVIFTFA--LAFLFWHRLW---SGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLVGMI 163
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 41-201 1.66e-04

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 41.64  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771  41 ADEVHALENVYFDEPLLWSMRSIATPALDAFFGAISKVGYQYGVIPADIAIALVLLVLQRWRegTFAALGFGGS--ALLN 118
Cdd:cd03398    25 AEYAAQLAEVKTLGGARSTSRTARQTAIAAFWADGPTPPGHWNQIARILAARPGLSLFRTAR--LFAAVNAAMTdaGIAA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 119 MGAKQFFQRDRP------------------SLWESIAPESTF-SFPSGHAMGSMTLAAVVIALAWSTRWRWPVTIV---- 175
Cdd:cd03398   103 WDAKYHYRRWRPvtairladtdgnpateadPYWLPLAGTPPHpSYPSGHATFAGAAATVLKALFGSDKVPDTVSEPdegg 182

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1215509771 176 ---------ASLFALL--VGISRIYLGVHYPSDILGG 201
Cdd:cd03398   183 pstgvtrvwAELNELAdeVAISRVYAGVHFRSDDAAG 219
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 142-217 2.02e-04

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 41.65  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215509771 142 FSFPSGHAMGSMTLAAVVIALAWS------TRWRWPVTIVASLFALLVGISRIYLGVHYPSDILGGwsaalvWVVGLYLV 215
Cdd:PLN02525   84 YGLPSSHTLNTVCLSGYLLHYVLSylqnvdASVIFAGLALFCLLVALVGFGRLYLGMHSPIDIIAG------LAIGLVIL 157


                  ..
gi 1215509771 216 MF 217
Cdd:PLN02525  158 AF 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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