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Conserved domains on  [gi|1211194232|gb|ASF42311|]
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glycosyl transferase family 2 [Capnocytophaga endodontalis]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10135561)

glycosyltransferase family 2 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 17-229 2.87e-41

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


:

Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 140.00  E-value: 2.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFACQTQQLQLFLVDNSPTDELKSLVTMYpDKEIHYIFNNENMGYGKAHNIAIKKSmeqGLPYHIVLNPDIVI 96
Cdd:cd04186    12 LKACLDSLLAQTYPDFEVIVVDNASTDGSVELLREL-FPEVRLIRNGENLGFGAGNNQGIREA---KGDYVLLLNPDTVV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  97 QKGTLEKLTHYMNHHPEVGNIMPKIiypngqlqylckllpspldlifrrfipfkkwrdksnkrfelhafsynktmnipil 176
Cdd:cd04186    88 EPGALLELLDAAEQDPDVGIVGPKV------------------------------------------------------- 112

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1211194232 177 SGCFMFLRTEALENVGLFDEHLFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHEY 229
Cdd:cd04186   113 SGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAgYRVLYVPQAVIYHHG 166
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 164-274 2.07e-04

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd02525:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 249  Bit Score: 41.83  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 164 AFSYNKTMNIPILSGCFMFLRTEALENVGLFDEHlFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHeYQKASYKniKLLKS 242
Cdd:cd02525   144 AYRGGAVKIGYVDTVHHGAYRREVFEKVGGFDES-LVRNEDAELNYRLRKAgYKIWLSPDIRVYY-YPRSTLK--KLARQ 219

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1211194232 243 hiksaiyYFNkYG-WFFDKERKKINQETLKQIL 274
Cdd:cd02525   220 -------YFR-YGkWRARTLRKHRKSLSLRHLL 244
 
Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 17-229 2.87e-41

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 140.00  E-value: 2.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFACQTQQLQLFLVDNSPTDELKSLVTMYpDKEIHYIFNNENMGYGKAHNIAIKKSmeqGLPYHIVLNPDIVI 96
Cdd:cd04186    12 LKACLDSLLAQTYPDFEVIVVDNASTDGSVELLREL-FPEVRLIRNGENLGFGAGNNQGIREA---KGDYVLLLNPDTVV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  97 QKGTLEKLTHYMNHHPEVGNIMPKIiypngqlqylckllpspldlifrrfipfkkwrdksnkrfelhafsynktmnipil 176
Cdd:cd04186    88 EPGALLELLDAAEQDPDVGIVGPKV------------------------------------------------------- 112

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1211194232 177 SGCFMFLRTEALENVGLFDEHLFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHEY 229
Cdd:cd04186   113 SGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAgYRVLYVPQAVIYHHG 166
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-258 1.62e-34

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 123.56  E-value: 1.62e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232   1 MKLSASIVLYQTdLTPLKKAIDSYFACQTQQLQLFLVDNSPTDELKSLVTMYPDKEIHYIFNNENMGYGKAHNIAIKKSm 80
Cdd:COG1216     3 PKVSVVIPTYNR-PELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALAFPRVRVIRNPENLGFAAARNLGLRAA- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  81 eqGLPYHIVLNPDIVIQKGTLEKLTHYmnhhpevgnimpkiiypngqlqylckllpspldlifrrfipfkkwrdksnkrf 160
Cdd:COG1216    81 --GGDYLLFLDDDTVVEPDWLERLLAA----------------------------------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 161 elhafsynktmnipilsgCFMFLRTEALENVGLFDEHLFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHeYQKASYKNIKL 239
Cdd:COG1216   106 ------------------ACLLIRREVFEEVGGFDERFFLYGEDVDLCLRLRKAgYRIVYVPDAVVYH-LGGASSGPLLR 166

                         250
                  ....*....|....*....
gi 1211194232 240 LKSHIKSAIYYFNKYGWFF 258
Cdd:COG1216   167 AYYLGRNRLLFLRKHGPRP 185
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 17-189 3.06e-09

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 54.71  E-value: 3.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFAcQT-QQLQLFLVDNSPTDELKSLVTMYPDKE--IHYIFNNENMGYGKAHNIAIKKSmeQGlPYHIVLNPD 93
Cdd:pfam00535  13 LLETLESLLN-QTyPNFEIIVVDDGSTDGTVEIAEEYAKKDprVRVIRLPENRGKAGARNAGLRAA--TG-DYIAFLDAD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  94 IVIQKGTLEKLTHYMNHHPEVGNIMPKIIYPNGQLQYlckllpsPLDLIFRRFIPFKKWRDKSnkrfelhafsynKTMNI 173
Cdd:pfam00535  89 DEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEY-------RRASRITLSRLPFFLGLRL------------LGLNL 149

                         170
                  ....*....|....*.
gi 1211194232 174 PILSGCFMFLRTEALE 189
Cdd:pfam00535 150 PFLIGGFALYRREALE 165
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 164-274 2.07e-04

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 41.83  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 164 AFSYNKTMNIPILSGCFMFLRTEALENVGLFDEHlFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHeYQKASYKniKLLKS 242
Cdd:cd02525   144 AYRGGAVKIGYVDTVHHGAYRREVFEKVGGFDES-LVRNEDAELNYRLRKAgYKIWLSPDIRVYY-YPRSTLK--KLARQ 219

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1211194232 243 hiksaiyYFNkYG-WFFDKERKKINQETLKQIL 274
Cdd:cd02525   220 -------YFR-YGkWRARTLRKHRKSLSLRHLL 244
 
Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 17-229 2.87e-41

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 140.00  E-value: 2.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFACQTQQLQLFLVDNSPTDELKSLVTMYpDKEIHYIFNNENMGYGKAHNIAIKKSmeqGLPYHIVLNPDIVI 96
Cdd:cd04186    12 LKACLDSLLAQTYPDFEVIVVDNASTDGSVELLREL-FPEVRLIRNGENLGFGAGNNQGIREA---KGDYVLLLNPDTVV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  97 QKGTLEKLTHYMNHHPEVGNIMPKIiypngqlqylckllpspldlifrrfipfkkwrdksnkrfelhafsynktmnipil 176
Cdd:cd04186    88 EPGALLELLDAAEQDPDVGIVGPKV------------------------------------------------------- 112

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1211194232 177 SGCFMFLRTEALENVGLFDEHLFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHEY 229
Cdd:cd04186   113 SGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAgYRVLYVPQAVIYHHG 166
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-258 1.62e-34

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 123.56  E-value: 1.62e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232   1 MKLSASIVLYQTdLTPLKKAIDSYFACQTQQLQLFLVDNSPTDELKSLVTMYPDKEIHYIFNNENMGYGKAHNIAIKKSm 80
Cdd:COG1216     3 PKVSVVIPTYNR-PELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALAFPRVRVIRNPENLGFAAARNLGLRAA- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  81 eqGLPYHIVLNPDIVIQKGTLEKLTHYmnhhpevgnimpkiiypngqlqylckllpspldlifrrfipfkkwrdksnkrf 160
Cdd:COG1216    81 --GGDYLLFLDDDTVVEPDWLERLLAA----------------------------------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 161 elhafsynktmnipilsgCFMFLRTEALENVGLFDEHLFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHeYQKASYKNIKL 239
Cdd:COG1216   106 ------------------ACLLIRREVFEEVGGFDERFFLYGEDVDLCLRLRKAgYRIVYVPDAVVYH-LGGASSGPLLR 166

                         250
                  ....*....|....*....
gi 1211194232 240 LKSHIKSAIYYFNKYGWFF 258
Cdd:COG1216   167 AYYLGRNRLLFLRKHGPRP 185
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 5-251 8.58e-20

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 85.41  E-value: 8.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232   5 ASIVLYQTDLTPLKKAIDSYFAcqtQQLQLFLVDNSP--TDELKSLvtmYPDKEIHYIFNNENMGYGKAHNIAIKKSMEQ 82
Cdd:cd02526     1 AVVVTYNPDLSKLKELLAALAE---QVDKVVVVDNSSgnDIELRLR---LNSEKIELIHLGENLGIAKALNIGIKAALEN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  83 GLPYHIVLNPDIVIQKGTLEKLTHY---MNHHPEVGNIMPKIIypngqlqylckllpsplDLIFRRFIPFKKwrdKSNKR 159
Cdd:cd02526    75 GADYVLLFDQDSVPPPDMVEKLLAYkilSDKNSNIGAVGPRII-----------------DRRTGENSPGVR---KSGYK 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 160 FELHAFSYNKTMNIPIL--SGCfmFLRTEALENVGLFDEHLFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHEYQKASYKN 236
Cdd:cd02526   135 LRIQKEGEEGLKEVDFLitSGS--LISLEALEKVGGFDEDLFIDYVDTEWCLRARSKgYKIYVVPDAVLKHELGDKRVKR 212

                         250
                  ....*....|....*..
gi 1211194232 237 IKLLKSHIKSAI--YYF 251
Cdd:cd02526   213 LGGVSVPLHSPLrrYYL 229
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 17-262 1.11e-15

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 75.16  E-value: 1.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFAcQT---QQLQLFLVDNSPTDELKSLVTMYPDKE--IHYIFNNENMGYGKAHNIAIKKSmeQGlPYHIVLN 91
Cdd:COG1215    44 IEETLRSLLA-QDypkEKLEVIVVDDGSTDETAEIARELAAEYprVRVIERPENGGKAAALNAGLKAA--RG-DIVVFLD 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  92 PDIVIQKGTLEKLTHYMnHHPEVGnimpkiiypngqlqylckllpspldlifrrfipfkkwrdksnkrfelhafsynktm 171
Cdd:COG1215   120 ADTVLDPDWLRRLVAAF-ADPGVG-------------------------------------------------------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 172 nipiLSGCFMFLRTEALENVGLFDEHlfMYMEDFDLNRRIHRA-YKTIFFPEAVVVHEYQKASYKNIKLLKSHIKSAIYY 250
Cdd:COG1215   143 ----ASGANLAFRREALEEVGGFDED--TLGEDLDLSLRLLRAgYRIVYVPDAVVYEEAPETLRALFRQRRRWARGGLQL 216

                         250
                  ....*....|..
gi 1211194232 251 FNKYGWFFDKER 262
Cdd:COG1215   217 LLKHRPLLRPRR 228
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 17-241 3.79e-11

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 61.26  E-value: 3.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFACQTQQLQLFLVDNSPTDE----LKSLVTMYPdkEIHYIFNNENMGYGKAHNIAIKKSmeQGlPYHIVLNP 92
Cdd:COG0463    17 LEEALESLLAQTYPDFEIIVVDDGSTDGtaeiLRELAAKDP--RIRVIRLERNRGKGAARNAGLAAA--RG-DYIAFLDA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  93 DIVIQKGTLEKLTHYMNHHPEvgnimpkiiypngqlqylckllpsplDLIF-RRFIPFKKWRDksnKRFELHAFSY-NKT 170
Cdd:COG0463    92 DDQLDPEKLEELVAALEEGPA--------------------------DLVYgSRLIREGESDL---RRLGSRLFNLvRLL 142

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1211194232 171 MNIPILSGCFMFLRTEALENVGlFDEHlfmYMEDFDLNRRIHRAYKTIFFPeavVVHEYQKASYKNIKLLK 241
Cdd:COG0463   143 TNLPDSTSGFRLFRREVLEELG-FDEG---FLEDTELLRALRHGFRIAEVP---VRYRAGESKLNLRDLLR 206
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 17-252 3.81e-11

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 61.11  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFAcQTQQL-QLFLVDNSPTDELKSLVT-MYPDKEIHYIFNNENMGYGKAHNIAIKKSMEQGLPYHIVLNPDI 94
Cdd:cd04185    12 LKECLDALLA-QTRPPdHIIVIDNASTDGTAEWLTsLGDLDNIVYLRLPENLGGAGGFYEGVRRAYELGYDWIWLMDDDA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  95 VIQKGTLEKLTHYMNHhPEVGNIMPKIIYPNGqlqylckllpspldlifrrfipfkkwrdksnkrfelhafsynktmnip 174
Cdd:cd04185    91 IPDPDALEKLLAYADK-DNPQFLAPLVLDPDG------------------------------------------------ 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 175 ilsgCF--MFLRTEALENVGLFDEHLFMYMEDFDLNRRIHRAYKTIFFPEAVVVHeyQKASYKNIKLLKSHIKSAIYYFN 252
Cdd:cd04185   122 ----SFvgVLISRRVVEKIGLPDKEFFIWGDDTEYTLRASKAGPGIYVPDAVVVH--KTAINKGSSAVVNIDPPWKLYYG 195
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 17-189 3.06e-09

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 54.71  E-value: 3.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFAcQT-QQLQLFLVDNSPTDELKSLVTMYPDKE--IHYIFNNENMGYGKAHNIAIKKSmeQGlPYHIVLNPD 93
Cdd:pfam00535  13 LLETLESLLN-QTyPNFEIIVVDDGSTDGTVEIAEEYAKKDprVRVIRLPENRGKAGARNAGLRAA--TG-DYIAFLDAD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  94 IVIQKGTLEKLTHYMNHHPEVGNIMPKIIYPNGQLQYlckllpsPLDLIFRRFIPFKKWRDKSnkrfelhafsynKTMNI 173
Cdd:pfam00535  89 DEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEY-------RRASRITLSRLPFFLGLRL------------LGLNL 149

                         170
                  ....*....|....*.
gi 1211194232 174 PILSGCFMFLRTEALE 189
Cdd:pfam00535 150 PFLIGGFALYRREALE 165
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 17-220 2.09e-08

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 52.51  E-value: 2.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  17 LKKAIDSYFACQTQQLQLFLVDNSPTDELKSLVTMYPDKE--IHYIFNNENMGYGKAHNIAIKKSmeQGlPYHIVLNPDI 94
Cdd:cd00761    12 LERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDprVIRVINEENQGLAAARNAGLKAA--RG-EYILFLDADD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  95 VIQKGTLEKLTHYMNHHPEVGnimpkIIYPNGqlqylckllpspldlifrrfipfkkwrdksnkrfelhafsynktmnip 174
Cdd:cd00761    89 LLLPDWLERLVAELLADPEAD-----AVGGPG------------------------------------------------ 115

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1211194232 175 ilsgcFMFLRTEALENVGLFDEHLFMYMEDFDLNRRIHRAYKTIFF 220
Cdd:cd00761   116 -----NLLFRRELLEEIGGFDEALLSGEEDDDFLLRLLRGGKVAFR 156
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 31-204 2.76e-08

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 52.23  E-value: 2.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  31 QLQLFLVDNSPTDELKSLVTMYPDKEI---HYIFNNENMGYGKAHNIAIKKSmeQGlPYHIVLNPDIVIQKGTLEKLTHY 107
Cdd:cd06423    26 KLEVIVVDDGSTDDTLEILEELAALYIrrvLVVRDKENGGKAGALNAGLRHA--KG-DIVVVLDADTILEPDALKRLVVP 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 108 MNHHPEVGNIMPKIIYPNGQLQYLCKLLpsplDLIFRRFIpfkkwrdksnkRFELHAFSYNKtmNIPILSGCFMFLRTEA 187
Cdd:cd06423   103 FFADPKVGAVQGRVRVRNGSENLLTRLQ----AIEYLSIF-----------RLGRRAQSALG--GVLVLSGAFGAFRREA 165

                         170
                  ....*....|....*..
gi 1211194232 188 LENVGLFDEHlfMYMED 204
Cdd:cd06423   166 LREVGGWDED--TLTED 180
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 35-236 9.81e-08

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 51.60  E-value: 9.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232  35 FLVDNSPT---DELKSLVTMYPDKEIHYIFNNENMG-YGKAHNIAIKKSMEQGlPYHIVLNPDIVIQKGTLEKLTHYMNH 110
Cdd:pfam13641  36 VVVNPSDAetlDVAEEIAARFPDVRLRVIRNARLLGpTGKSRGLNHGFRAVKS-DLVVLHDDDSVLHPGTLKKYVQYFDS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 111 HPeVGNImpkiiypngQLQYLCKLLPSPLDLIFRRFipFKKWrdksNKRFELHAfsynKTMNIPILSGCFMFLRTEALEN 190
Cdd:pfam13641 115 PK-VGAV---------GTPVFSLNRSTMLSALGALE--FALR----HLRMMSLR----LALGVLPLSGAGSAIRREVLKE 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1211194232 191 VGLFDEhLFMYMEDFDLNRRIHRA-YKTIFFPEAVVVH---EYQKASYKN 236
Cdd:pfam13641 175 LGLFDP-FFLLGDDKSLGRRLRRHgWRVAYAPDAAVRTvfpTYLAASIKQ 223
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 181-226 4.62e-05

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 43.33  E-value: 4.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1211194232 181 MFLRTEALENVGLFDEHLFMymEDFDLNRRIHRAYKTIFFPEAVVV 226
Cdd:cd02522   141 LFIRRELFEELGGFPELPLM--EDVELVRRLRRRGRPALLPSPVTT 184
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 164-274 2.07e-04

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 41.83  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 164 AFSYNKTMNIPILSGCFMFLRTEALENVGLFDEHlFMYMEDFDLNRRIHRA-YKTIFFPEAVVVHeYQKASYKniKLLKS 242
Cdd:cd02525   144 AYRGGAVKIGYVDTVHHGAYRREVFEKVGGFDES-LVRNEDAELNYRLRKAgYKIWLSPDIRVYY-YPRSTLK--KLARQ 219

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1211194232 243 hiksaiyYFNkYG-WFFDKERKKINQETLKQIL 274
Cdd:cd02525   220 -------YFR-YGkWRARTLRKHRKSLSLRHLL 244
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 156-228 3.16e-03

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 37.70  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211194232 156 SNKRFELHAFSYNKTMNIPILSGC-----------FMFLRTEALENVGLFDEhlFMYMEDFDLNRRIHRAYKTIFFPEAV 224
Cdd:pfam13632  41 GNYLEELAALFFADDHGKSIPVRMalgrvlpfvgsGAFLRRSALQEVGGWDD--GSVSEDFDFGLRLQRAGYRVRFAPYS 118


                  ....
gi 1211194232 225 VVHE 228
Cdd:pfam13632 119 AVYE 122
CESA_like_2 cd06427
CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) ...
 171-217 3.44e-03

CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, Glucan Biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of glucan.


Pssm-ID: 133049 [Multi-domain]  Cd Length: 241  Bit Score: 38.00  E-value: 3.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1211194232 171 MNIPI-LSGCFMFLRTEALENVGLFDEhlFMYMEDFDLNRRIHRA-YKT 217
Cdd:cd06427   155 LGLPIpLGGTSNHFRTDVLRELGGWDP--FNVTEDADLGLRLARAgYRT 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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