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Conserved domains on  [gi|1208604885|gb|ASB50596|]
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acetate kinase [Alkalitalea saponilacus]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-399 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 680.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   1 MKILVLNCGSSSIKYQLFFMEGETwdVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSdlHGC 80
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMDSEE--VLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTD--HGI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKH 160
Cdd:COG0282    77 IKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 161 AYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMM 240
Cdd:COG0282   157 AYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 241 GTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1208604885 321 AMGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGlRGKEMDISKKESKCRIMVVPTNEELVIAVDTKKIV 399
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAA-RGGERVISTPDSRVKVLVIPTNEELMIARDTLRLL 394
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-399 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 680.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   1 MKILVLNCGSSSIKYQLFFMEGETwdVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSdlHGC 80
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMDSEE--VLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTD--HGI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKH 160
Cdd:COG0282    77 IKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 161 AYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMM 240
Cdd:COG0282   157 AYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 241 GTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1208604885 321 AMGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGlRGKEMDISKKESKCRIMVVPTNEELVIAVDTKKIV 399
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAA-RGGERVISTPDSRVKVLVIPTNEELMIARDTLRLL 394
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 670.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   1 MKILVLNCGSSSIKYQLFFMEGEtwDVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSDLHGC 80
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMPNE--EVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKH 160
Cdd:PRK00180   79 IKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 161 AYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMM 240
Cdd:PRK00180  159 AYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVM 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 241 GTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAA 320
Cdd:PRK00180  239 GTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 321 AM-GGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKN-TGLRGKEMDISKKESKCRIMVVPTNEELVIAVDTKKI 398
Cdd:PRK00180  319 ALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNlAARFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRL 398


                  .
gi 1208604885 399 V 399
Cdd:PRK00180  399 L 399
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-398 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 647.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   3 ILVLNCGSSSIKYQLFFMEGETwdVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSDLHGCik 82
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEE--VLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGV-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  83 EMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKHAY 162
Cdd:cd24010    77 SLDEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 163 MYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMMGT 242
Cdd:cd24010   157 LYALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 243 RCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAAAM 322
Cdd:cd24010   237 RSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAAL 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1208604885 323 GGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGLRGKEMDISKKESKCRIMVVPTNEELVIAVDTKKI 398
Cdd:cd24010   317 GGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-392 7.95e-176

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 495.41  E-value: 7.95e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   2 KILVLNCGSSSIKYQLFfmEGETWDVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSdlHGCI 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLF--DAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLK--HKII 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  82 KEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKHA 161
Cdd:pfam00871  77 ELLAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 162 YMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMMG 241
Cdd:pfam00871 157 YLYALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 242 TRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAAA 321
Cdd:pfam00871 237 TRSGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAAS 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1208604885 322 MGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGlRGKEMDISKKESKCRIMVVPTNEELVIA 392
Cdd:pfam00871 317 LERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNR-FGKSGVISTEDSRVKVVVIPTNEELMIA 386
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-395 1.24e-171

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 485.38  E-value: 1.24e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   1 MKILVLNCGSSSIKYQLFFMEGETwDVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSdlHGC 80
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAVNGE-EVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLK--DKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSL--LPNVPQVGVFDTAFHQTMP 158
Cdd:TIGR00016  81 IKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLfpLPKAKNVAVFDTAFHQTMP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 159 KHAYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGL 238
Cdd:TIGR00016 161 EEAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 239 MMGTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSY 318
Cdd:TIGR00016 241 MMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1208604885 319 AAAMGG-VDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGLR-GKEMDISKKESKCRIMVVPTNEELVIAVDT 395
Cdd:TIGR00016 321 IASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARsGKSGVISTPESKVKILVIPTNEELMIAQDA 399
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-399 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 680.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   1 MKILVLNCGSSSIKYQLFFMEGETwdVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSdlHGC 80
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMDSEE--VLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTD--HGI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKH 160
Cdd:COG0282    77 IKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 161 AYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMM 240
Cdd:COG0282   157 AYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 241 GTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1208604885 321 AMGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGlRGKEMDISKKESKCRIMVVPTNEELVIAVDTKKIV 399
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAA-RGGERVISTPDSRVKVLVIPTNEELMIARDTLRLL 394
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 670.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   1 MKILVLNCGSSSIKYQLFFMEGEtwDVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSDLHGC 80
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMPNE--EVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKH 160
Cdd:PRK00180   79 IKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 161 AYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMM 240
Cdd:PRK00180  159 AYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVM 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 241 GTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAA 320
Cdd:PRK00180  239 GTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 321 AM-GGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKN-TGLRGKEMDISKKESKCRIMVVPTNEELVIAVDTKKI 398
Cdd:PRK00180  319 ALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNlAARFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRL 398


                  .
gi 1208604885 399 V 399
Cdd:PRK00180  399 L 399
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-398 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 647.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   3 ILVLNCGSSSIKYQLFFMEGETwdVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSDLHGCik 82
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEE--VLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGV-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  83 EMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKHAY 162
Cdd:cd24010    77 SLDEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 163 MYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMMGT 242
Cdd:cd24010   157 LYALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 243 RCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAAAM 322
Cdd:cd24010   237 RSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAAL 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1208604885 323 GGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGLRGKEMDISKKESKCRIMVVPTNEELVIAVDTKKI 398
Cdd:cd24010   317 GGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-392 7.95e-176

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 495.41  E-value: 7.95e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   2 KILVLNCGSSSIKYQLFfmEGETWDVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSdlHGCI 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLF--DAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLK--HKII 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  82 KEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKHA 161
Cdd:pfam00871  77 ELLAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 162 YMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMMG 241
Cdd:pfam00871 157 YLYALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 242 TRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAAA 321
Cdd:pfam00871 237 TRSGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAAS 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1208604885 322 MGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGlRGKEMDISKKESKCRIMVVPTNEELVIA 392
Cdd:pfam00871 317 LERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNR-FGKSGVISTEDSRVKVVVIPTNEELMIA 386
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-395 1.24e-171

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 485.38  E-value: 1.24e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   1 MKILVLNCGSSSIKYQLFFMEGETwDVMAKGGVEKIGLKGSFLKHEKSNGEKVLLEGEILDHETGIDYILGILLSdlHGC 80
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAVNGE-EVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLK--DKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSL--LPNVPQVGVFDTAFHQTMP 158
Cdd:TIGR00016  81 IKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLfpLPKAKNVAVFDTAFHQTMP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 159 KHAYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGL 238
Cdd:TIGR00016 161 EEAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 239 MMGTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSY 318
Cdd:TIGR00016 241 MMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1208604885 319 AAAMGG-VDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGLR-GKEMDISKKESKCRIMVVPTNEELVIAVDT 395
Cdd:TIGR00016 321 IASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARsGKSGVISTPESKVKILVIPTNEELMIAQDA 399
PRK12397 PRK12397
acetate/propionate family kinase;
2-398 8.38e-147

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 422.33  E-value: 8.38e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   2 KILVLNCGSSSIKYQLFFMEGEtwDVMAKGGVEKIGLKGSFLKHeKSNGEKVLLEGEILDHETGIDYILGILLSdlHGCI 81
Cdd:PRK12397    4 KIMAINAGSSSLKFQLLEMPQG--DMLCQGLIERIGMADAQVTI-KTHSQKWQETVPVADHRDAVTLLLEKLLG--YQII 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  82 KEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKHA 161
Cdd:PRK12397   79 NSLRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 162 YMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMMG 241
Cdd:PRK12397  159 YIYPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 242 TRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAAA 321
Cdd:PRK12397  239 TRSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQ 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1208604885 322 MGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNtglRGKEMDISKKESKCRIMVVPTNEELVIAVDTKKI 398
Cdd:PRK12397  319 MGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKN---QRNATFIQTENALVKVAVINTNEELMIAQDVMRI 392
PRK12379 PRK12379
propionate kinase;
3-394 8.71e-134

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 389.10  E-value: 8.71e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   3 ILVLNCGSSSIKYQLffMEGETWDVMAKGGVEKIGLKGSFLKHekSNGEKVLLEGEilDHETGIDYILGILLS-DLhgci 81
Cdd:PRK12379    7 VLVINCGSSSIKFSV--LDASDCEVLMSGIADGINSENAFLSV--NGGEPAPLAHH--SYEGALKAIAFELEKrNL---- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  82 keMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKHA 161
Cdd:PRK12379   77 --NDSVALIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 162 YMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMMG 241
Cdd:PRK12379  155 YLYGLPWEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 242 TRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAAA 321
Cdd:PRK12379  235 TRSGDVDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAAS 314

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1208604885 322 MGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGL-RGKEMDISKKESKCRIMVVPTNEELVIAVD 394
Cdd:PRK12379  315 LHRLDGIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPnSGGERIISSENSRVICAVIPTNEEKMIALD 388
PRK07157 PRK07157
acetate kinase; Provisional
 1-398 2.16e-126

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 370.23  E-value: 2.16e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   1 MKILVLNCGSSSIKYQLFfmEGETWDVMAKGGVEKIGLKGSFLKhEKSNGEKVLLEGEILDHETGIDYILGILLSdlHGC 80
Cdd:PRK07157    3 AKILVINAGSSSIKWQLF--DKENLNLIASGLAERIGLENGLIK-IKFGKKKYEKEVDMPNHKVAVAVLIEIWEE--NKL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKH 160
Cdd:PRK07157   78 IEDLEEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 161 AYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALgvDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMM 240
Cdd:PRK07157  158 NYTYPINYEIAKKYGIKKYGFHGISHKFITNKVEKIL--NKDKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMM 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 241 GTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAA 320
Cdd:PRK07157  236 GTRSGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYIN 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 321 AMGG-VDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGLRGKEMD---ISKKESKCRIMVVPTNEELVIAVDTK 396
Cdd:PRK07157  316 KIGKkIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKIGEYGPielISTPDSDIPVYVIRTNEELLIAKNAI 395


                  ..
gi 1208604885 397 KI 398
Cdd:PRK07157  396 KL 397
PRK12440 PRK12440
acetate/propionate family kinase;
3-392 5.68e-121

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 356.48  E-value: 5.68e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   3 ILVLNCGSSSIKYQLffMEGETWDVMAKGGVEKIGLKGSFLKHeKSNGEK--VLLEGEILDHETGIDYILGILLSdlhgc 80
Cdd:PRK12440    6 VLVINSGSSSLKFAV--IDSVTGEAVLSGLGECFGLEDARMSW-KYQGEKteIAIEGEDNHHKIAIGRLVGLTEE----- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  81 IKEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMPKH 160
Cdd:PRK12440   78 LGFTQDIVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 161 AYMYAIPFSLYKKYGVRRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGLMM 240
Cdd:PRK12440  158 AFTGAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMM 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 241 GTRCGDLDIGAATYIMDKELIGIQSASILfNKHSGMLGVTGISSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAA 320
Cdd:PRK12440  238 GTRCGDLDPGIIEFLLKKGWSQEKVFNSL-NKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLA 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1208604885 321 AMGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGLR-GKEMDISKKESKCRI-MVVPTNEELVIA 392
Cdd:PRK12440  317 ALDSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARfGKAGIIAKSELLNAVaMVIPTNEEFVIA 390
PRK07058 PRK07058
acetate/propionate family kinase;
3-395 3.29e-98

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 298.12  E-value: 3.29e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   3 ILVLNCGSSSIKYQLFFMEGETWDVMAKGgveKIGLKGSFLKHEKSNGEKVL---LEGEILDHETG-IDYILGiLLSDLH 78
Cdd:PRK07058    6 LLTFNAGSSTVKIGLFEVDGNEARRIGKG---DIDFRRAPLRFHLRNGGETLdipLKASVTDDLHTvLDETFD-WLAAHF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  79 gcikEMEEIDAVGHRVVHGGETFNSSVFITDEVISKMEDCIDLAPLHNPPNLKGIRAISSLLPNVPQVGVFDTAFHQTMP 158
Cdd:PRK07058   82 ----DVSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 159 KHAYMYAIPFSLYKKyGVRRYGFHGTSHRYVSKRACEaLGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFTPLEGL 238
Cdd:PRK07058  158 DLVRRFAIPRALHDE-GIKRYGFHGLSYKFVAGELRR-RAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGI 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 239 MMGTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGISSDMREIesaLEKKDPMAELGMSMYNYRIKKFVGSY 318
Cdd:PRK07058  236 PMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDL---LASDAPEAREALDLFALRIAGEIARL 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1208604885 319 AAAMGGVDILIFTGGIGENGDLTRREVCKGLDFMGMVLDDEKNTGLRGKemdISKKESKCRIMVVPTNEELVIAVDT 395
Cdd:PRK07058  313 AATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAANAFT---ISSRTSRVAAFVIPTDEEQVIADEA 386
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 2-343 6.46e-25

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 104.15  E-value: 6.46e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885   2 KILVLNCGSSSIKYQLFfmEGETwdvmakggvekiGLKGSFLKHeksngekvlLEGEILDHET---GIDYILGILLSDLH 78
Cdd:cd24011     1 RILVINPGSTSTKIAVF--EGEE------------EVFEETIEH---------SPEELAKFPSiidQLEFRKEAVLDFLK 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885  79 GCIKEMEEIDAVGHRV-----VHGGetfnssvfiTDEVISKMEDCIDLAPLHNPP-NLKGI--RAISSLLpNVPqvgvfd 150
Cdd:cd24011    58 ENGIDLSDLDAIVGRGgllkpIPGG---------TYRVNEAMLEDLLSGPLGEHAsNLGAPiaYELAKEY-GIP------ 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 151 tafhqtmpkhAYMYAiPFSLY------KKYGV----RRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAI 220
Cdd:cd24011   122 ----------AYIVD-PVVVDemdpvaRITGIpeieRRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAH 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 221 MNGESVDTSMGFtPLEGLMMGTRCGDLDIGAATYIMDKELIGIQSASILFNKHSGMLGVTGIsSDMREIESALEKKDPMA 300
Cdd:cd24011   191 RKGRVIDVNNAL-DGEGPFSPERAGTLPVGDLIKLCFSGKYTLEELKKKLKGKGGLVAYLGT-NDFREVEKRIEAGDEKA 268

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1208604885 301 ELGMSMYNYRIKKFVGSYAAAMGG-VDILIFTGGIGENGDLTRR 343
Cdd:cd24011   269 KLVLDAMAYQIAKEIGALAAVLKGkVDAIILTGGLAYSKRLVDR 312
PRK03011 PRK03011
butyrate kinase; Provisional
 177-343 5.55e-17

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 81.74  E-value: 5.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 177 RRYGFHGTSHRYVSKRACEALGVDYKKQRIISCHLGNGASVAAIMNGESVDTSMGFtPLEGLMMGTRCGDLDIGA----- 251
Cdd:PRK03011  149 RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGGLPVGDlvelc 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208604885 252 ----ATYimdKELIGiqsasiLFNKHSGMLGVTGiSSDMREIESALEKKDPMAELGMSMYNYRIKKFVGSYAAAMGG-VD 326
Cdd:PRK03011  228 fsgkYTK---EELKK------KLVGKGGLVAYLG-TNDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKGkVD 297

                         170
                  ....*....|....*..
gi 1208604885 327 ILIFTGGIGENGDLTRR 343
Cdd:PRK03011  298 AIVLTGGLAYSKRLVER 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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