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Conserved domains on  [gi|1199086527|gb|ARU28084|]
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NAD-dependent DNA ligase [Cellvibrio sp. PSBB006]

Protein Classification

BRCT domain-containing protein( domain architecture ID 13027032)

BRCT (BRCA1 C-terminus) domain-containing protein may interact with DNA, and participate in DNA-damage checkpoint or DNA-repair pathways

Gene Ontology:  GO:0003677
PubMed:  14576433|10946236

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCT_DNA_ligase_like cd17748
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also ...
 114-195 3.22e-17

BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


:

Pssm-ID: 349379 [Multi-domain]  Cd Length: 76  Bit Score: 72.51  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199086527 114 FHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLGTYVtdswahetfGRKIEKAMEYRDSGVPLVIVTEE 193
Cdd:cd17748     1 LAGKTFVFTGTLSSMSRDEAEELIEALGGKVQSSVSKKTDYLVVGDNA---------GSKLKKGEELKAKGLGIKIISEE 71


                  ..
gi 1199086527 194 HW 195
Cdd:cd17748    72 EF 73
 
Name Accession Description Interval E-value
BRCT_DNA_ligase_like cd17748
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also ...
 114-195 3.22e-17

BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349379 [Multi-domain]  Cd Length: 76  Bit Score: 72.51  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199086527 114 FHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLGTYVtdswahetfGRKIEKAMEYRDSGVPLVIVTEE 193
Cdd:cd17748     1 LAGKTFVFTGTLSSMSRDEAEELIEALGGKVQSSVSKKTDYLVVGDNA---------GSKLKKGEELKAKGLGIKIISEE 71


                  ..
gi 1199086527 194 HW 195
Cdd:cd17748    72 EF 73
Lig COG0272
NAD-dependent DNA ligase [Replication, recombination and repair];
113-195 4.43e-10

NAD-dependent DNA ligase [Replication, recombination and repair];


Pssm-ID: 440042 [Multi-domain]  Cd Length: 668  Bit Score: 58.11  E-value: 4.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199086527 113 TFHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLGtyvtdswahETFGRKIEKAMEYrdsGVPlvIVTE 192
Cdd:COG0272   595 PLAGKTFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAG---------ENAGSKLDKAEEL---GVP--ILDE 660


                  ...
gi 1199086527 193 EHW 195
Cdd:COG0272   661 AEF 663
ligA PRK14351
NAD-dependent DNA ligase LigA; Provisional
 108-158 3.36e-07

NAD-dependent DNA ligase LigA; Provisional


Pssm-ID: 184640 [Multi-domain]  Cd Length: 689  Bit Score: 49.75  E-value: 3.36e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1199086527 108 PQPAIT-----FHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLG 158
Cdd:PRK14351  599 PQPAESeggdaLDGLTFVFTGSLSGYTRSEAQELVEAHGGNATGSVSGNTDYLVVG 654
 
Name Accession Description Interval E-value
BRCT_DNA_ligase_like cd17748
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also ...
 114-195 3.22e-17

BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349379 [Multi-domain]  Cd Length: 76  Bit Score: 72.51  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199086527 114 FHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLGTYVtdswahetfGRKIEKAMEYRDSGVPLVIVTEE 193
Cdd:cd17748     1 LAGKTFVFTGTLSSMSRDEAEELIEALGGKVQSSVSKKTDYLVVGDNA---------GSKLKKGEELKAKGLGIKIISEE 71


                  ..
gi 1199086527 194 HW 195
Cdd:cd17748    72 EF 73
Lig COG0272
NAD-dependent DNA ligase [Replication, recombination and repair];
113-195 4.43e-10

NAD-dependent DNA ligase [Replication, recombination and repair];


Pssm-ID: 440042 [Multi-domain]  Cd Length: 668  Bit Score: 58.11  E-value: 4.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199086527 113 TFHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLGtyvtdswahETFGRKIEKAMEYrdsGVPlvIVTE 192
Cdd:COG0272   595 PLAGKTFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAG---------ENAGSKLDKAEEL---GVP--ILDE 660


                  ...
gi 1199086527 193 EHW 195
Cdd:COG0272   661 AEF 663
ligA PRK14351
NAD-dependent DNA ligase LigA; Provisional
 108-158 3.36e-07

NAD-dependent DNA ligase LigA; Provisional


Pssm-ID: 184640 [Multi-domain]  Cd Length: 689  Bit Score: 49.75  E-value: 3.36e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1199086527 108 PQPAIT-----FHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLG 158
Cdd:PRK14351  599 PQPAESeggdaLDGLTFVFTGSLSGYTRSEAQELVEAHGGNATGSVSGNTDYLVVG 654
ligA PRK07956
NAD-dependent DNA ligase LigA; Validated
 109-195 7.86e-07

NAD-dependent DNA ligase LigA; Validated


Pssm-ID: 236137 [Multi-domain]  Cd Length: 665  Bit Score: 48.58  E-value: 7.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199086527 109 QPAITFHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLGtyvtdswahETFGRKIEKAMEYrdsGVPlv 188
Cdd:PRK07956  586 GEEVDLAGKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAG---------EAAGSKLAKAQEL---GIE-- 651


                  ....*..
gi 1199086527 189 IVTEEHW 195
Cdd:PRK07956  652 VLDEEEF 658
PRK06195 PRK06195
DNA polymerase III subunit epsilon; Validated
 91-193 4.22e-06

DNA polymerase III subunit epsilon; Validated


Pssm-ID: 235735 [Multi-domain]  Cd Length: 309  Bit Score: 45.93  E-value: 4.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199086527  91 SSTLGELTKTTTL---PINKPQPAI----TFHGMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLGTYVTD 163
Cdd:PRK06195  191 SSRKGRILKRSNRqapRKKKKIIESfgftAFKEEVVVFTGGLASMTRDEAMILVRRLGGTVGSSVTKKTTYLVTNTKDIE 270

                          90       100       110
                  ....*....|....*....|....*....|
gi 1199086527 164 SWAHETFGRKIEKAMEYRDSGVPLVIVTEE 193
Cdd:PRK06195  271 DLNREEMSNKLKKAIDLKKKGQNIKFLNEE 300
BRCT_RFC1 cd17752
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ...
 116-193 2.95e-05

BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349383 [Multi-domain]  Cd Length: 79  Bit Score: 41.04  E-value: 2.95e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1199086527 116 GMTFLFTGTCAFGTRAQCQAAVETLGGVNAGSVNKSLNYLVLGtyvtdswaHETFGRKIEKAMEYrdsGVPlvIVTEE 193
Cdd:cd17752     8 GLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVG--------RDAGPSKLEKAKEL---GTK--IIDED 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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