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Conserved domains on  [gi|1198342568|gb|ART95452|]
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PTS sugar transporter subunit IIC [Lacticaseibacillus rhamnosus]

Protein Classification

PTS sugar transporter subunit IIC( domain architecture ID 10508028)

phosphotransferase system (PTS) sugar transporter subunit IIC catalyzes the transfer of a phosphoryl group from IIB to sugar substrates concomitant with their translocation across the cell membrane

Gene Ontology:  GO:0009401|GO:0016020|GO:0034219
PubMed:  15667312
TCDB:  4.A.6.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ManY super family cl42157
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
1-225 3.30e-46

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG3715:

Pssm-ID: 442929  Cd Length: 259  Bit Score: 154.50  E-value: 3.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568   1 MVLGVGTFGGASKIDANSGTLLATAFSVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIE 80
Cdd:COG3715    59 IYLGVVNIGGAVPPDPALAGIIGTALAILSGQDPETAIALAVPVGL-LGQVLDILVRTINSFFVHKADKYAEEGNFKGIE 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  81 RYFLAGALPWALSRMIPVGLALAFGGGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFI 160
Cdd:COG3715   138 RLHLLGPLLQFLLRAIPVFLALYFGADAVQALLNAIP---AWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFV 214
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1198342568 161 FtmlfttlfgniqtlgtavagvaknftATFNGLSMLAIALIGFAFAAISYQQSTQLHDSVGGGSE 225
Cdd:COG3715   215 L--------------------------AAYLKLPLLAIAIIGVAIALIYYQLKKKKNAAAAAASG 253
 
Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
1-225 3.30e-46

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 442929  Cd Length: 259  Bit Score: 154.50  E-value: 3.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568   1 MVLGVGTFGGASKIDANSGTLLATAFSVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIE 80
Cdd:COG3715    59 IYLGVVNIGGAVPPDPALAGIIGTALAILSGQDPETAIALAVPVGL-LGQVLDILVRTINSFFVHKADKYAEEGNFKGIE 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  81 RYFLAGALPWALSRMIPVGLALAFGGGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFI 160
Cdd:COG3715   138 RLHLLGPLLQFLLRAIPVFLALYFGADAVQALLNAIP---AWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFV 214
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1198342568 161 FtmlfttlfgniqtlgtavagvaknftATFNGLSMLAIALIGFAFAAISYQQSTQLHDSVGGGSE 225
Cdd:COG3715   215 L--------------------------AAYLKLPLLAIAIIGVAIALIYYQLKKKKNAAAAAASG 253
EII-Sor pfam03609
PTS system sorbose-specific iic component;
1-208 3.57e-41

PTS system sorbose-specific iic component;


Pssm-ID: 460987  Cd Length: 233  Bit Score: 140.62  E-value: 3.57e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568   1 MVLGVGTFGGASKIDANSGTLLATAFSVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIE 80
Cdd:pfam03609  55 MYLGVVTIGGAVPPDAALAGIIGTALAILSGIGPEAAIALAVPVAL-LGQQLDNLVRTINSFFVHKADKYAEEGNYKGIE 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  81 R-YFLAGALPWALSRMIPVGLALAFGGGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGF 159
Cdd:pfam03609 134 RiHLLGPQLLGLLIRFIPVFLALYFGADAVQALLNAIP---EWLTNGLTVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGF 210
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1198342568 160 IFtmlfttlfgniqtlgtavagvaknftATFNGLSMLAIALIGFAFAAI 208
Cdd:pfam03609 211 VL--------------------------AAYLKLPLIAIAIIGVAIALI 233
PRK15065 PRK15065
mannose/fructose/sorbose family PTS transporter subunit IIC;
54-229 2.54e-09

mannose/fructose/sorbose family PTS transporter subunit IIC;


Pssm-ID: 237895  Cd Length: 262  Bit Score: 56.00  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  54 ILARFANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGL-ALAFGGGFVTniaHALNTDWKWLGDGLATAGA 132
Cdd:PRK15065  111 IIVRTITVAFQHAADKAAEEGNFRAIEWLHVSALLLQALRIAIPAALvALAVGTSAVQ---SMLNAIPEVLTGGLNIGGG 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568 133 VLPAVGFAILLHYLPVKKHFAYLILGFIftmlfttlfgniqtlgtavagvaknfTATFNGLSMLAIALIGFAFAAIsYQQ 212
Cdd:PRK15065  188 MIVVVGYAMVINMMATRELMPFFYLGFV--------------------------LAAFTNLNLIALGVIGVVLALI-YLQ 240
                         170
                  ....*....|....*..
gi 1198342568 213 STQLHDSVGGGSEANGG 229
Cdd:PRK15065  241 LSPKYGRVAGGGAAGSG 257
 
Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
1-225 3.30e-46

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 442929  Cd Length: 259  Bit Score: 154.50  E-value: 3.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568   1 MVLGVGTFGGASKIDANSGTLLATAFSVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIE 80
Cdd:COG3715    59 IYLGVVNIGGAVPPDPALAGIIGTALAILSGQDPETAIALAVPVGL-LGQVLDILVRTINSFFVHKADKYAEEGNFKGIE 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  81 RYFLAGALPWALSRMIPVGLALAFGGGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFI 160
Cdd:COG3715   138 RLHLLGPLLQFLLRAIPVFLALYFGADAVQALLNAIP---AWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFV 214
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1198342568 161 FtmlfttlfgniqtlgtavagvaknftATFNGLSMLAIALIGFAFAAISYQQSTQLHDSVGGGSE 225
Cdd:COG3715   215 L--------------------------AAYLKLPLLAIAIIGVAIALIYYQLKKKKNAAAAAASG 253
EII-Sor pfam03609
PTS system sorbose-specific iic component;
1-208 3.57e-41

PTS system sorbose-specific iic component;


Pssm-ID: 460987  Cd Length: 233  Bit Score: 140.62  E-value: 3.57e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568   1 MVLGVGTFGGASKIDANSGTLLATAFSVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIE 80
Cdd:pfam03609  55 MYLGVVTIGGAVPPDAALAGIIGTALAILSGIGPEAAIALAVPVAL-LGQQLDNLVRTINSFFVHKADKYAEEGNYKGIE 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  81 R-YFLAGALPWALSRMIPVGLALAFGGGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGF 159
Cdd:pfam03609 134 RiHLLGPQLLGLLIRFIPVFLALYFGADAVQALLNAIP---EWLTNGLTVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGF 210
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1198342568 160 IFtmlfttlfgniqtlgtavagvaknftATFNGLSMLAIALIGFAFAAI 208
Cdd:pfam03609 211 VL--------------------------AAYLKLPLIAIAIIGVAIALI 233
PRK15065 PRK15065
mannose/fructose/sorbose family PTS transporter subunit IIC;
54-229 2.54e-09

mannose/fructose/sorbose family PTS transporter subunit IIC;


Pssm-ID: 237895  Cd Length: 262  Bit Score: 56.00  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  54 ILARFANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGL-ALAFGGGFVTniaHALNTDWKWLGDGLATAGA 132
Cdd:PRK15065  111 IIVRTITVAFQHAADKAAEEGNFRAIEWLHVSALLLQALRIAIPAALvALAVGTSAVQ---SMLNAIPEVLTGGLNIGGG 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568 133 VLPAVGFAILLHYLPVKKHFAYLILGFIftmlfttlfgniqtlgtavagvaknfTATFNGLSMLAIALIGFAFAAIsYQQ 212
Cdd:PRK15065  188 MIVVVGYAMVINMMATRELMPFFYLGFV--------------------------LAAFTNLNLIALGVIGVVLALI-YLQ 240
                         170
                  ....*....|....*..
gi 1198342568 213 STQLHDSVGGGSEANGG 229
Cdd:PRK15065  241 LSPKYGRVAGGGAAGSG 257
PRK09757 PRK09757
PTS N-acetylgalactosamine transporter subunit IIC;
47-180 4.00e-04

PTS N-acetylgalactosamine transporter subunit IIC;


Pssm-ID: 236621  Cd Length: 267  Bit Score: 40.60  E-value: 4.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  47 SIMIQTDILARF-ANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGLALAFGGGFVTNIAHALNtdwKWLGD 125
Cdd:PRK09757  104 SLLMQYVILFFYsAFSLFMTKADKCAKEADTAAFSRLNWTTMLIVASAYAVIAFLCTYLAQGAMQALVKAMP---AWLTH 180
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1198342568 126 GLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFIFTML--FTTLFgNIQTLGTAVA 180
Cdd:PRK09757  181 GFEVAGGILPAVGFGLLLRVMFKAQYIPYLIAGFLFVCYiqVSNLL-PVAVLGAGFA 236
NodJ COG3559
Putative exporter of oligosaccharides and polyketide antibiotics DrrB/NodJ, ABC-2 family ...
84-208 4.46e-03

Putative exporter of oligosaccharides and polyketide antibiotics DrrB/NodJ, ABC-2 family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442780 [Multi-domain]  Cd Length: 529  Bit Score: 37.92  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198342568  84 LAGALP---WALSRMIP---VGLALAFGGGFVTNIAHALNT-DWKWLGDGLATAGAVLPAV----GFAILLH-YLPvkkH 151
Cdd:COG3559   378 LATAVSrtrWLASHLAVaalGSAVLLLVAGLGLGLGAAAVTgDPGSLGRLLGAALAQLPAVlvvlGLAVLLFgLLP---R 454
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1198342568 152 FAYLILGFIFTMLFTTLFGNIQTLGTAVAG------VAKNFTATFNGLSMLAIALIGFAFAAI 208
Cdd:COG3559   455 LAGLAWLVLAYSFVVGYLGPLLDLPQWVLDlspfghVPQLPAEDFDWAPLLVLTALAAALVAL 517
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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