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Conserved domains on  [gi|1169003018|gb|ARB37153|]
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XylR family transcriptional regulator [Bacillus subtilis]

Protein Classification

xylose repressor( domain architecture ID 11212051)

xylose repressor acts as a transcriptional repressor of xylose-utilizing enzymes

CATH:  3.30.420.40
Gene Ontology:  GO:0042732|GO:0003677
PubMed:  8800467|7781919|7952186
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 80-377 6.57e-147

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


:

Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 418.12  E-value: 6.57e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  80 GYSVGIDVGVDYINGILTDLEGTIVLDQYRHL-ESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLID-KDQK 157
Cdd:cd24076     1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLpASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDsEDGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 158 IVFTPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGE 237
Cdd:cd24076    81 VLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 238 MGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKK---LSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILN 314
Cdd:cd24076   161 IGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGgepLSLAELVEAARAGDPAALAALEEVGEYLGIGLANLVN 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169003018 315 TFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDH 377
Cdd:cd24076   241 TFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAAALAIDH 303
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
13-56 4.64e-05

Winged helix-turn-helix DNA-binding;


:

Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 40.49  E-value: 4.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1169003018  13 NQKLLLKEILKNSPISRAKLSEMTGLNKSTVSSQVSTLMKENLV 56
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 80-377 6.57e-147

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 418.12  E-value: 6.57e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  80 GYSVGIDVGVDYINGILTDLEGTIVLDQYRHL-ESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLID-KDQK 157
Cdd:cd24076     1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLpASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDsEDGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 158 IVFTPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGE 237
Cdd:cd24076    81 VLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 238 MGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKK---LSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILN 314
Cdd:cd24076   161 IGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGgepLSLAELVEAARAGDPAALAALEEVGEYLGIGLANLVN 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169003018 315 TFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDH 377
Cdd:cd24076   241 TFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAAALAIDH 303
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 83-376 1.03e-133

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 384.00  E-value: 1.03e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIVLDQYRHlesNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLI-DKDQKIVFT 161
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVP---TPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLIsPKYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 162 PNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGHM 241
Cdd:pfam00480  78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 242 TIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAV 321
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINLFDPQAI 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1169003018 322 ILRNSIIESHPMvLNSMRSEVSSRVYSQLGNSY-ELLPSSLGQNAPALGMSSIVID 376
Cdd:pfam00480 238 VLGGGVSNADGL-LEAIRSLVKKYLNGYLPVPPvIIVAASLGDNAGALGAAALAKQ 292
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 76-376 1.85e-107

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 317.99  E-value: 1.85e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  76 NKKAGYSVGIDVGVDYINGILTDLEGTIVLDQYRHLESN-SPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDK 154
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGaGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 155 DQKIV-FTPN-SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVS 232
Cdd:COG1940    81 ETGVVlNAPNlPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 233 GFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQ--TKAKKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLT 310
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARelGGAEKLTAEELFAAARAGDPLALEVLDEAARYLGIGLA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1169003018 311 NILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVID 376
Cdd:COG1940   241 NLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAALALE 306
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 83-380 1.22e-45

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 159.30  E-value: 1.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIvLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIV-FT 161
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNI-LSKWKVPTDTTPETIVDAIASAVDSFIQHIAKVGHEIVAIGIGAPGPVNRQRGTVyFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 162 PNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGHM 241
Cdd:TIGR00744  80 VNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGHI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 242 TIDFNGP-KCSCGNRGCWELYASEKALL--------------KSLQTKA-KKLSYQDIIDLAHLNDIGTLNALQNFGFYL 305
Cdd:TIGR00744 160 RMVPDGRlLCNCGKQGCIETYASATGLVryakranakperaeVLLALGDgDGISAKHVFVAARQGDPVAVDSYREVARWA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1169003018 306 GIGLTNILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLD 380
Cdd:TIGR00744 240 GAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSYKRWLFGGARQVADIIAAQLGNDAGLVGAADLARTYIIE 314
PRK09698 PRK09698
D-allose kinase; Provisional
 77-323 3.02e-23

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 98.52  E-value: 3.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  77 KKAGYSVGIDVGVDYINGILTDLEGTIV-LDQYRHLESNSPEITKDiLIDMIHHFITQMPQSPYGlIGIGIcvPGLIDKD 155
Cdd:PRK09698    1 KQKNVVLGIDMGGTHIRFCLVDAEGEILhCEKKRTAEVIAPDLVSG-LGEMIDEYLRRFNARCHG-IVMGF--PALVSKD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 156 QKIVF-TPN---SNWRDIDLKSSIQEKYNVPVFIENEANAgaygeKVFGAAKNH----DNIIYVSISTGIGIGVIINNHL 227
Cdd:PRK09698   77 RRTVIsTPNlplTALDLYDLADKLENTLNCPVFFSRDVNL-----QLLWDVKENnltqQLVLGAYLGTGMGFAVWMNGAP 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 228 YRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKKLSYQDIIDLAhlndiGTLNALQNFGFYLGI 307
Cdd:PRK09698  152 WTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCSGMALRRWYEQQPRDYPLSDLFVHA-----GDHPFIQSLLENLAR 226

                         250
                  ....*....|....*.
gi 1169003018 308 GLTNILNTFNPQAVIL 323
Cdd:PRK09698  227 AIATSINLFDPDAIIL 242
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
13-56 4.64e-05

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 40.49  E-value: 4.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1169003018  13 NQKLLLKEILKNSPISRAKLSEMTGLNKSTVSSQVSTLMKENLV 56
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 21-73 2.10e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 36.49  E-value: 2.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1169003018  21 ILKNSPISRAKLSEMTGLNKSTVSSQVSTLMKENLVfeigqgqSSGGRRPVML 73
Cdd:cd00092    20 DLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLI-------SRRGRGKYRV 65
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 80-377 6.57e-147

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 418.12  E-value: 6.57e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  80 GYSVGIDVGVDYINGILTDLEGTIVLDQYRHL-ESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLID-KDQK 157
Cdd:cd24076     1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLpASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDsEDGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 158 IVFTPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGE 237
Cdd:cd24076    81 VLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 238 MGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKK---LSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILN 314
Cdd:cd24076   161 IGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGgepLSLAELVEAARAGDPAALAALEEVGEYLGIGLANLVN 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169003018 315 TFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDH 377
Cdd:cd24076   241 TFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAAALAIDH 303
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 83-376 1.03e-133

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 384.00  E-value: 1.03e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIVLDQYRHlesNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLI-DKDQKIVFT 161
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVP---TPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLIsPKYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 162 PNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGHM 241
Cdd:pfam00480  78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 242 TIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAV 321
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINLFDPQAI 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1169003018 322 ILRNSIIESHPMvLNSMRSEVSSRVYSQLGNSY-ELLPSSLGQNAPALGMSSIVID 376
Cdd:pfam00480 238 VLGGGVSNADGL-LEAIRSLVKKYLNGYLPVPPvIIVAASLGDNAGALGAAALAKQ 292
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 80-379 6.36e-110

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 323.72  E-value: 6.36e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  80 GYSVGIDVGVDYINGILTDLEGTIV-LDQYRHLESNSPEItKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDkDQKI 158
Cdd:cd24077     1 GYSIGIDLGYNYISLMLTYLDGEIIsSKQIKLLDISFENI-LEILKSIIQELISQAPKTPYGLVGIGIGIHGIVD-ENEI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 159 VFTPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAakNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEM 238
Cdd:cd24077    79 IFTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERTFSE--DYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 239 GHMTIDFNGPKCSCGNRGCWELYASEKALLKSL--QTKAKKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNTF 316
Cdd:cd24077   157 GHMIIVPNGKPCPCGNKGCLEQYASEKALLKELseKKGLETLTFDDLIQLYNEGDPEALELIDQFIKYLAIGINNIINTF 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169003018 317 NPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLgnsyELLPSSLGQNAPALGMSSIVIDHFL 379
Cdd:cd24077   237 NPEIIIINSSLINEIPELLEKIKEQLSSSFNKYV----EILISTLGKNATLLGGAAVAIKNFL 295
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 76-376 1.85e-107

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 317.99  E-value: 1.85e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  76 NKKAGYSVGIDVGVDYINGILTDLEGTIVLDQYRHLESN-SPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDK 154
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGaGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 155 DQKIV-FTPN-SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVS 232
Cdd:COG1940    81 ETGVVlNAPNlPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 233 GFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQ--TKAKKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLT 310
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARelGGAEKLTAEELFAAARAGDPLALEVLDEAARYLGIGLA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1169003018 311 NILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVID 376
Cdd:COG1940   241 NLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAALALE 306
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 81-379 2.28e-85

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 261.37  E-value: 2.28e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  81 YSVGIDVGVDYINGILTDLEGTIVLdQYRHL--ESNSPEITKDILIDMIHHFITQMPQSPyGLIGIGICVPGLIDKDQKI 158
Cdd:cd24059     2 YVIGVEIGRDLLSAVLCDLSGNILA-REKYPldEKENPEEVLEKLYELIDRLLEKENIKS-KILGIGIGAPGPLDVEKGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 159 VFTPN--SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSG 236
Cdd:cd24059    80 ILNPPnfPGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 237 EMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKKL--SYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILN 314
Cdd:cd24059   160 EIGHTSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGSGrsFQLDIVEALQKGDPIADEVIEEAAKYLGIGLVNLIN 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1169003018 315 TFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFL 379
Cdd:cd24059   240 LLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRILKSSLGEDAPLLGAAALVLNKYF 304
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 80-379 1.47e-78

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 244.00  E-value: 1.47e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  80 GYSVGIDVGVDYINGILTDLEGTIVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIV 159
Cdd:cd24073     1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 160 -FTPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEM 238
Cdd:cd24073    81 rWSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 239 GHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKK---LSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNT 315
Cdd:cd24073   161 GHTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLRgepLTIEDLLAAARAGDPAARAILRRAGRALGLALANLVNL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1169003018 316 FNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFL 379
Cdd:cd24073   241 LDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDLELVIHPWGDEAWARGAAALALQEFF 304
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 83-369 4.83e-69

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 217.33  E-value: 4.83e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIVLDQYRHLESN-SPEITKDILIDMIHHFITQMPQsPYGLIGIGICVPGLID-KDQKIVF 160
Cdd:cd23763     1 IGIDIGGTKIRAALVDLDGEILARERVPTPAEeGPEAVLDRIAELIEELLAEAGV-RERILGIGIGVPGPVDpETGIVLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 161 TPN-SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMG 239
Cdd:cd23763    80 APNlPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 240 HMTIdfngpkcscgnrgcwelyasekallkslqtkakklsyqdiidlahlndigtlnaLQNFGFYLGIGLTNILNTFNPQ 319
Cdd:cd23763   160 HITV------------------------------------------------------LEEAARYLGIGLANLINLLNPE 185

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1169003018 320 AVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALG 369
Cdd:cd23763   186 LIVLGGGVAEAGDLLLEPIREAVRRRALPPLRRRVRIVPSELGDDAGLLG 235
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 80-379 4.62e-67

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 214.84  E-value: 4.62e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  80 GYSVGIDVGVDYINGILTDLEGTIVLDQYRHLESNS-PEITKDILIDMIHHFITQMPqSPYGLIGIGICVPGLIDKDQKI 158
Cdd:cd24071     1 GYIIGVKIEEGYLVLALTDLKGKILEKTRIPFDHETdPEKVIELIAENIKKLIKNKH-VEKKLLGIGIAVSGLVDSKKGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 159 V-FTPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGE 237
Cdd:cd24071    80 ViRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 238 MGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQ--TKAKKLSYQD---------IIDLAHLNDIGTLNALQNFGFYLG 306
Cdd:cd24071   160 IGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKelTESYPLSLLKeledfeiekVREAAEEGDSVATELFKKAGEYLG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169003018 307 IGLTNILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFL 379
Cdd:cd24071   240 IGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSLGEDAWVLGAALLVIDHLF 312
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 83-370 7.04e-63

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 203.17  E-value: 7.04e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIVldqYRHLESNSPEITKDILIDMIHHFITQmPQSPYGLIGIGICVPGLIDKDQKIVF-- 160
Cdd:cd24068     3 LGIDIGGTKIKYGLVDADGEIL---EKDSVPTPASKGGDAILERLLEIIAE-LKEKYDIEGIGISSAGQVDPKTGEVIya 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 161 TPN-SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMG 239
Cdd:cd24068    79 TDNlPGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 240 HMTIDFNGPKCSCGNRGCWELYASEKALLKSLQ--TKAKKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNTFN 317
Cdd:cd24068   159 HMVVDPGGRPCCCGGKGCLEQYASGTALVRRVAeaLGEPGIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVHIFD 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1169003018 318 PQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGM 370
Cdd:cd24068   239 PEVIVIGGGISAQGELFLEELREELRKLLMPPLLDATKIEPAKLGNDAGLLGA 291
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 82-339 1.97e-59

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 194.88  E-value: 1.97e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  82 SVGIDVGVDYINGILTDLEGTIvLDQYRHLESNSPEITKDILIDMIHHFitqmpQSPYGLIGIGICVPGLIDKDQKIV-F 160
Cdd:cd24061     1 TIGVDIGGTKIAAGVVDEEGEI-LATERVPTPPTADGIVDAIVEAVEEL-----REGHDVSAVGVAAAGFVDADRATVlF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 161 TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGH 240
Cdd:cd24061    75 APNIAWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFGH 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 241 MTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKA----------------KKLSYQDIIDLAHLNDIGTLNALQNFGFY 304
Cdd:cd24061   155 IRVVPDGLLCGCGSRGCWEQYASGRALVRYAKEAAnatpegaavlladgsvDGITGKHISEAARAGDPVALDALRELARW 234

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1169003018 305 LGIGLTNILNTFNPQAVILRNSIIESHPMVLNSMR 339
Cdd:cd24061   235 LGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIR 269
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 83-373 9.15e-53

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 177.30  E-value: 9.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIVLDQYRHLESnspEITKDILIDMIHHFITQMPQSPyGLIGIGICVPGLIDKDQKIV-FT 161
Cdd:cd24064     2 IGIDLGGTDTKIGIVDENGDILKKKTIDTKV---ENGKEDVINRIAETVNELIEEM-ELLGIGIGSPGSIDRENGIVrFS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 162 PN-SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGH 240
Cdd:cd24064    78 PNfPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAELGH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 241 MTIDFNGPKCSCGNRGCWELYASEKALLK-----------SLQTKAKKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGL 309
Cdd:cd24064   158 VIVEPNGPICGCGNRGCVEAFASATAIIRyaresrkrypdSLAGESEKINAKHVFDAARKNDPLATMVFRRVVDALAIAI 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1169003018 310 TNILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSI 373
Cdd:cd24064   238 GGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVMLSFQDTYSIELSNLVEDAGILGAASI 301
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 83-373 1.48e-49

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 169.39  E-value: 1.48e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYIN-GILTdLEGTIVldqYRH-----LESNSPEITKDIlIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQ 156
Cdd:cd24062     3 VGIDVGGTTIKmAFLT-QEGEIV---QKWeiptnKLEGGENIITDI-AESIQQLLEELGYSKEDLIGIGVGVPGPVDVET 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 157 KIVF-TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFS 235
Cdd:cd24062    78 GTVEvAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 236 GEMGHMTIDFNGP-KCSCGNRGCWELYAS---------------EKALLKSLQTKAKKLSYQDIIDLAHLNDIGTLNALQ 299
Cdd:cd24062   158 GEIGHITVNPEGGaPCNCGKTGCLETVASatgivriareeleegKGSSALRILALGGELTAKDVFEAAKAGDELALAVVD 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1169003018 300 NFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSI 373
Cdd:cd24062   238 TVARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKEYFDRFTFPRVRQDTEIVLATLGNDAGVIGAAWL 311
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 81-369 1.10e-47

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 164.43  E-value: 1.10e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  81 YSVGIDVGVDYINGILTDLEGTIVLDQY-RHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPgLIDKDQKIV 159
Cdd:cd24063     1 YYVAVDIGGTWIRAGLVDEDGRILLKIRqPTPKTGDPGTVSEQVLGLIETLLSKAGKDSIEGIGVSSAGP-LDLRKGTIV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 160 FTPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMG 239
Cdd:cd24063    80 NSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 240 HMTIDFN-GPKCSCGNRGCWELYASEKALLKSLQTKAKKLSYQ----------------DIIDLAHLNDIGTLNALQNFG 302
Cdd:cd24063   160 HLVVDTEsGLKCGCGGYGHWEAFASGRGIPRFAREWAEGFSSRtslklrnpggegitakEVFSAARKGDPLALKIIEKLA 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1169003018 303 FYLGIGLTNILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRvySQLGNSYELLPSSLGQNAPALG 369
Cdd:cd24063   240 RYNGRGIANVINAYDPELIVIGGSVFNNNKDILDPLIEYLEKN--PAISKGPEIVLSELGDDVGLIG 304
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 81-374 1.38e-46

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 161.77  E-value: 1.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  81 YSVGIDVGVDYINGILTDLEGTIVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQ-KIV 159
Cdd:cd24075     2 HILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTgVVH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 160 FTPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMG 239
Cdd:cd24075    82 YMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 240 HMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTK-----AKKLSYQ-----DIIDLAHLNDIGTLNALQNFGFYLGIGL 309
Cdd:cd24075   162 HIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLlkqgyASQLTLQdctikDICQAALNGDQLAQDVIKRAGRYLGKVI 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1169003018 310 TNILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNApALGMSSIV 374
Cdd:cd24075   242 AILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNS-AIGAFALV 305
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 82-369 7.10e-46

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 159.03  E-value: 7.10e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  82 SVGIDVGVDYI-NGILTDleGTIVldqyRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLID-KDQKIV 159
Cdd:cd24065     2 TIGLDLGGTKIaAGVVDG--GRIL----SRLVVPTPREGGEAVLDALARAVEALQAEAPGVEAVGLGVPGPLDfRRGRVR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 160 FTPN-SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEM 238
Cdd:cd24065    76 FAPNiPGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 239 GHMTIDFNGPKCSCGNRGCWELYASEKAlLKSLQTKA--KKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNTF 316
Cdd:cd24065   156 GHTTVLPGGPMCGCGLVGCLEALASGRA-LARDASFAygRPMSTAELFELAQQGEPKALRIVEQAAAHLGIGLANLQKAL 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1169003018 317 NPQAVILRNSIIESHPMVLNSMRSevSSRVYSQLGNSYELLPSSLGQNAPALG 369
Cdd:cd24065   235 DPEVFVLGGGVAQVGDYYLLPVQE--AARRYTEGWHAPPLRLAHLGTDAGVIG 285
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 83-380 1.22e-45

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 159.30  E-value: 1.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIvLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIV-FT 161
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNI-LSKWKVPTDTTPETIVDAIASAVDSFIQHIAKVGHEIVAIGIGAPGPVNRQRGTVyFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 162 PNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGHM 241
Cdd:TIGR00744  80 VNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGHI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 242 TIDFNGP-KCSCGNRGCWELYASEKALL--------------KSLQTKA-KKLSYQDIIDLAHLNDIGTLNALQNFGFYL 305
Cdd:TIGR00744 160 RMVPDGRlLCNCGKQGCIETYASATGLVryakranakperaeVLLALGDgDGISAKHVFVAARQGDPVAVDSYREVARWA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1169003018 306 GIGLTNILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLD 380
Cdd:TIGR00744 240 GAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSYKRWLFGGARQVADIIAAQLGNDAGLVGAADLARTYIIE 314
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 83-370 2.18e-44

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 155.65  E-value: 2.18e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIVLD-QYRHLESNSPEITKDILIDMIHHfitQMPQSPYGLIGIGICVPGLIDKDQK-IVF 160
Cdd:cd24072     4 LGIVVSPNSLRAQVGNACGELLGEfEYRVITLETPEALIDEIIDCIDR---LLKLWKDRVKGIALAIQGLVDSHKGvSLW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 161 TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGH 240
Cdd:cd24072    81 SPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEIGH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 241 MTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAK---------KLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTN 311
Cdd:cd24072   161 TKVNPDGARCDCGRRGCLETVASNSALKRNARVTLKlgpvsadpeKLTMEQLIEALEEGEPIATQIFDRAANAIGRSLAN 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1169003018 312 ILNTFNPQAVILRNSIIESHPMVLNSMRSEVSSRVYSQLGNS--YELLPSSLGQNAPALGM 370
Cdd:cd24072   241 ILNLLNPEQVLLYGRGCRAGDLLLPAIRRAIAENPFSQHATQigFGQLSTEQGCAQQALGL 301
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 141-323 4.51e-40

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 144.10  E-value: 4.51e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 141 LIGIGICVPGLIDKDQKIVFTPNS---NWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGI 217
Cdd:cd24060    60 ILGVGISTGGRVNPREGIVLHSTKliqEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGI 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 218 GIGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKAllksLQTKAKKL------------------- 278
Cdd:cd24060   140 GGGIILNHELIHGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMA----LQREAKKLhdedlllvegmsvtndeev 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1169003018 279 SYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVIL 323
Cdd:cd24060   216 TAKHLIQAAKLGNAKAQKILRTAGTALGLGIVNILHTLNPSLVIL 260
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 96-349 9.38e-40

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 143.61  E-value: 9.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  96 LTDLEG-TIVLDQYR-HLESNSPEITKdiLIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVFT-PNSNWRDIDLK 172
Cdd:cd24074    18 LRDLNGrLLAEERYPlPAKDNDPFLDR--LLESISEFFSRHQKKLERLTAIAITLPGIIDPESGIVHRlPFYDIKNLPLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 173 SSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSC 252
Cdd:cd24074    96 EALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELGHTQIDPYGKRCYC 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 253 GNRGCWELYASEKALLKSLQTKAK----------KLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQaVI 322
Cdd:cd24074   176 GNHGCLETVASIPAILEQANQLLEqspdsmlhgqPISIESLCQAALAGDPLAQDIIIQVGRHLGRILAILVNLFNPE-KI 254

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1169003018 323 LRNSIIES-----HPMVLNSMRSEvSSRVYSQ 349
Cdd:cd24074   255 LIGSPLNNaaeilFPALSQSIRQQ-SLPAYSQ 285
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 81-323 1.34e-37

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 137.30  E-value: 1.34e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  81 YSVGIDVGVDYINGILTDLEGTIVldQYRHLESNSPEITKD---ILIDMIHHFITQMPQSPyglIGIGICVPGLIDKD-Q 156
Cdd:cd24070     2 YVLGIDIGGTNIRIGLVDEDGKLL--DFEKVPSKDLLRAGDpveVLADLIREYIEEAGLKP---AAIVIGVPGTVDKDrR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 157 KIVFTPN-SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFS 235
Cdd:cd24070    77 TVISTPNiPGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKNGVA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 236 GEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKKLSYQDIIdLAHLNDIgtlnALQNFGFYLGIGLTNILNT 315
Cdd:cd24070   157 GELGHIPVYGNGKPCGCGNTGCLETYASGRALEEIAEEHYPDTPILDIF-VDHGDEP----ELDEFVEDLALAIATEINI 231


                  ....*...
gi 1169003018 316 FNPQAVIL 323
Cdd:cd24070   232 LDPDAVIL 239
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 143-323 1.21e-34

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 129.23  E-value: 1.21e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 143 GIGICVPGLIDKDQKIVFT--PNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIG 220
Cdd:cd24152    56 GIAISAPGVIDPETGIIYGggALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGA 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 221 VIINNHLYRGVSGFSGEMGHMTIDFNGPkcscgNRGCWELYASEKALLKS-LQTKAKKLSY-QDIIDLAHLNDIGTLNAL 298
Cdd:cd24152   136 IIIDGKLYRGSHFFAGEFSYLLTDDDDK-----DLLFFSGLASMFGLVKRyNKAKGLEPLDgEEIFEKYAKGDEAAKKIL 210

                         170       180
                  ....*....|....*....|....*
gi 1169003018 299 QNFGFYLGIGLTNILNTFNPQAVIL 323
Cdd:cd24152   211 DEYIRNLAKLIYNIQYILDPEVIVI 235
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 113-291 6.26e-32

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 121.62  E-value: 6.26e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 113 SNSPEITKDILIDMIHHFITQMPQspygligIGICVPGLIDkDQKIVFTPNSN---WRDIDLKSSIQEKYNVPVFIENEA 189
Cdd:cd24069    31 SGTPEALADALASLLADYQGQFDR-------VAVASTGIIR-DGVLTALNPKNlggLSGFPLADALQQLLGVPVVLLNDA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 190 NAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLK 269
Cdd:cd24069   103 QAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHTLADPPGPVCGCGRRGCVEAIASGTAIAA 182

                         170       180
                  ....*....|....*....|...
gi 1169003018 270 -SLQTKAKKLSYQDIIDLAHLND 291
Cdd:cd24069   183 aASEILGEPVDAKDVFERARSGD 205
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 83-323 1.62e-29

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 115.38  E-value: 1.62e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLEGTIVldqYRHlESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVFTP 162
Cdd:cd24066     2 IGIDLGGTKIEGIALDRAGREL---LRR-RVPTPRGDYEATLDAIADLVEEAEEELGAPATVGIGTPGSISPRTGLVKNA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 163 NSNWRD-IDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGHM 241
Cdd:cd24066    78 NSTWLNgKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGEWGHN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 242 TID------FNGPKCSCGNRGCWELYASEKALLKSLQTKA-KKLSYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILN 314
Cdd:cd24066   158 PLPwpdedeLPGPPCYCGKRGCVETFLSGPALERDYARLTgKTLSAEEIVALARAGDAAAVATLDRFLDRLGRALANVIN 237


                  ....*....
gi 1169003018 315 TFNPQAVIL 323
Cdd:cd24066   238 ILDPDVIVL 246
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 115-323 2.55e-27

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 109.17  E-value: 2.55e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 115 SPEITKDILIDmihhFITQmPQSPYGLIGIGICVPGLIDKDQK----IVFTPNSNWRDIDLKSSIQEKYNVPVFIENEAN 190
Cdd:cd24067    32 TPEETLQAVID----FFRE-QEEPIDAIGIASFGPIDLNPTSPtygyITTTPKPGWRNFDILGALKRAFPVPVGFDTDVN 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 191 AGAYGEKVFGAAKNHDNIIYVSISTGIGIGVIINNHLYRGVSgfSGEMGHMTI-------DFNGpKCSCGNrGCWELYAS 263
Cdd:cd24067   107 AAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHGLL--HPEMGHIRVprhpdddGFPG-VCPFHG-DCLEGLAS 182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1169003018 264 EKALLKSLQTKAKKLSYQDII-DLAhlndigtlnalqnfGFYLGIGLTNILNTFNPQAVIL 323
Cdd:cd24067   183 GPAIAARWGIPAEELPDDHPAwDLE--------------AYYLAQACANLTLTLSPERIVL 229
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 140-323 6.36e-24

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 100.38  E-value: 6.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 140 GLIGIGIcvPGLIDKDQKIVFTPN----SNWRdidLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSIST 215
Cdd:cd24057    58 GPVGIGI--PGVIDPEDGTLITANipaaKGRP---LRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGT 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 216 GIGIGVIINNHLYRGVSGFSGEMGHM-------TIDFNGP--KCSCGNRGCWELYASEKALLKSLQTKAKK-LSYQDIID 285
Cdd:cd24057   133 GVGGGLVVNGRLVGGRSGIAGEWGHGplpadalLLGYDLPvlRCGCGQTGCLETYLSGRGLERLYAHLYGEeLDAPEIIA 212

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1169003018 286 LAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVIL 323
Cdd:cd24057   213 AWAAGDPQAVAHVDRWLDLLAGCLANILTALDPDVVVL 250
PRK09698 PRK09698
D-allose kinase; Provisional
 77-323 3.02e-23

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 98.52  E-value: 3.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  77 KKAGYSVGIDVGVDYINGILTDLEGTIV-LDQYRHLESNSPEITKDiLIDMIHHFITQMPQSPYGlIGIGIcvPGLIDKD 155
Cdd:PRK09698    1 KQKNVVLGIDMGGTHIRFCLVDAEGEILhCEKKRTAEVIAPDLVSG-LGEMIDEYLRRFNARCHG-IVMGF--PALVSKD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 156 QKIVF-TPN---SNWRDIDLKSSIQEKYNVPVFIENEANAgaygeKVFGAAKNH----DNIIYVSISTGIGIGVIINNHL 227
Cdd:PRK09698   77 RRTVIsTPNlplTALDLYDLADKLENTLNCPVFFSRDVNL-----QLLWDVKENnltqQLVLGAYLGTGMGFAVWMNGAP 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 228 YRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKAKKLSYQDIIDLAhlndiGTLNALQNFGFYLGI 307
Cdd:PRK09698  152 WTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCSGMALRRWYEQQPRDYPLSDLFVHA-----GDHPFIQSLLENLAR 226

                         250
                  ....*....|....*.
gi 1169003018 308 GLTNILNTFNPQAVIL 323
Cdd:PRK09698  227 AIATSINLFDPDAIIL 242
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 171-291 2.91e-19

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 86.89  E-value: 2.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 171 LKSSIQEKYNVPVFIENEANAGAYGEkvFGAAKNH-DNIIYVSISTGIGIGVIINNHLYRGVSGFSGEMGHMTIDFNGPK 249
Cdd:PRK05082   88 LVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDiRNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHGPV 165

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1169003018 250 CSCGNRGCWELYASEKALLKSLQTKAKKLSYQDIIDLAHLND 291
Cdd:PRK05082  166 CGCGRRGCVEAIASGRAIAAAAQGWLAGCDAKTIFERAGQGD 207
PRK09557 PRK09557
fructokinase; Reviewed
 140-323 6.15e-18

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 83.54  E-value: 6.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 140 GLIGIGIcvPGLIDKDQKIVFTPNSNW-----RDIDLKssiqEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSIS 214
Cdd:PRK09557   58 GTVGVGI--PGSISPYTGLVKNANSTWlngqpLDKDLS----ARLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIG 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 215 TGIGIGVIINNHLYRGVSGFSGEMGH-----MTID----FNGPKCSCGNRGCWELYASEKALLKSLQT-KAKKLSYQDII 284
Cdd:PRK09557  132 TGCGAGVAINGRVHIGGNGIAGEWGHnplpwMDEDelryRNEVPCYCGKQGCIETFISGTGFATDYRRlSGKALKGSEII 211

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1169003018 285 DLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVIL 323
Cdd:PRK09557  212 RLVEEGDPVAELAFRRYEDRLAKSLAHVINILDPDVIVL 250
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 139-323 7.77e-15

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 74.25  E-value: 7.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 139 YGLIGIGIcvPGLIDKDQKIVFTpnSNWRDID---LKSSIQEKYNVPVFIENEANAGAYGEkvfgaAKNHDNIIYVS--- 212
Cdd:PRK13310   57 KGSVGIGI--PGMPETEDGTLYA--ANVPAASgkpLRADLSARLGRDVRLDNDANCFALSE-----AWDDEFTQYPLvmg 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 213 --ISTGIGIGVIINNHLYRGVSGFSGEMGHMTID--------FNGP--KCSCGNRGCWELYASEK--ALLKSlQTKAKKL 278
Cdd:PRK13310  128 liLGTGVGGGLVFNGKPISGRSYITGEFGHMRLPvdaltllgWDAPlrRCGCGQKGCIENYLSGRgfEWLYQ-HYYGEPL 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1169003018 279 SYQDIIDLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVIL 323
Cdd:PRK13310  207 QAPEIIALYYQGDEQAVAHVERYLDLLAICLGNILTIVDPHLVVL 251
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 83-244 2.51e-14

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 71.83  E-value: 2.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  83 VGIDVGVDYINGILTDLE-GTIVLDQYRhLESNSPEiTKDILIDMIHHFITQMPqsPYGLIGIGIcvPGLIdKDQKIVFT 161
Cdd:cd24058     2 LGIDIGGSGIKGAIVDTDtGELLSERIR-IPTPQPA-TPEAVADVVAELVAHFP--WFGPVGVGF--PGVV-RRGVVRTA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 162 PN--SNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDN-IIYVSISTGIGIGVIINNHLYrgvsgFSGEM 238
Cdd:cd24058    75 ANldKSWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGvVLVLTLGTGIGSALFVDGHLV-----PNTEL 149


                  ....*.
gi 1169003018 239 GHMTID 244
Cdd:cd24058   150 GHLEIR 155
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 140-267 3.59e-10

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 60.04  E-value: 3.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 140 GLIGIGIcvPGLIDKDQKIVFTPN-----SNWRDIDLKSSIQEKynvpVFIENEANAGAYGEKVFGAAKNHDNIIYVSIS 214
Cdd:PRK13311   58 GSVGIGI--PGLPNADDGTVFTANvpsamGQPLQADLSRLIQRE----VRIDNDANCFALSEAWDPEFRTYPTVLGLILG 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169003018 215 TGIGIGVIINNHLYRGVSGFSGEMGHMTIDFNG--------PK--CSCGNRGCWELYASEKAL 267
Cdd:PRK13311  132 TGVGGGLIVNGSIVSGRNHITGEFGHFRLPVDAldilgadiPRvpCGCGHRGCIENYISGRGF 194
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
13-56 4.64e-05

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 40.49  E-value: 4.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1169003018  13 NQKLLLKEILKNSPISRAKLSEMTGLNKSTVSSQVSTLMKENLV 56
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 21-73 2.10e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 36.49  E-value: 2.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1169003018  21 ILKNSPISRAKLSEMTGLNKSTVSSQVSTLMKENLVfeigqgqSSGGRRPVML 73
Cdd:cd00092    20 DLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLI-------SRRGRGKYRV 65
ASKHA_NBD_MurK-like cd24084
nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid ...
 81-244 7.54e-03

nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK) and similar proteins; The family includes a group of uncharacterized proteins similar to Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK; EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase. It catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. Neither the non-N-acetylated forms of the cell wall sugars, i.e., glucosamine and/or muramic acid, nor epimeric hexoses or 1,6-anhydro-MurNAc are substrates for the enzyme. MurK may have a role in the rescue of the murein sugars GlcNAc and MurNAc released from muropeptides during cell wall turnover in C.acetobutylicum.


Pssm-ID: 466934 [Multi-domain]  Cd Length: 302  Bit Score: 38.11  E-value: 7.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018  81 YSVGIDVGVDYINGILTDLEGTIVLDQYR---HLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQK 157
Cdd:cd24084     2 YVIGIDGGGTKTHLKITDLNGNVVGEGFGgssNLESNSLETVRENLKELFQDFYEQLGKSLKECGSICLGTAGASHQGAK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169003018 158 IVFTpnsnwrdiDLKSSIqeKYNVPVFIENEANAGAYGEkvfgaAKNHDNIIYVSISTGIGIGVIINNHLYRgvsgfSGE 237
Cdd:cd24084    82 ETLK--------DILTEL--GPDAKIEVVNDAEIALAAG-----LEGKPGIVLISGTGSICYGRNTDGETAR-----AGG 141


                  ....*..
gi 1169003018 238 MGHMTID 244
Cdd:cd24084   142 WGHLLGD 148
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 20-63 7.60e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 7.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1169003018  20 EILKNSPISRAKLSEMTGLNKSTVSSQVSTLMKENLVFEIGQGQ 63
Cdd:cd00090    14 RLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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