|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
1-376 |
2.30e-55 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 186.66 E-value: 2.30e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIP 80
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNAVGA 160
Cdd:cd17329 84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 161 VMAGIFYVRFFRKRhkiyqKKMKEKPIVKETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSI 240
Cdd:cd17329 164 LLAALVLLFLLPET-----RPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 241 GYILGYSGFIIVVLEMLVVNFADKYlTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALR 320
Cdd:cd17329 239 GLLLALNALLIVLLQFPVARLVERF-RLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAAL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1154496064 321 SGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMY 376
Cdd:cd17329 318 APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-379 |
1.59e-37 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 139.25 E-value: 1.59e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGSMVLPFLGVYMTDqLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPI 81
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 82 FTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS-FSYELLFITNAVGA 160
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 161 VMAGIFYVRFFRKRHKIYQKKMKEKPIVKETLEKERspyRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSI 240
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL---RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 241 GYILGYSGFIIVVLEMLVVNFADKYLTIaKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALR 320
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1154496064 321 SGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMYFVV 379
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-339 |
3.90e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.54 E-value: 3.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDqLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIP 80
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS-FSYELLFITNAVG 159
Cdd:COG2814 94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 160 AVMAGIFYVRFFRKRHKIYQKKMKekpivketlEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKS 239
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARARLR---------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 240 IGYILGYSGFIIVVLEMLVVNFADKYlTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITAL 319
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRF-GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|
gi 1154496064 320 RSGKTNQGAYMGLNGMTFSI 339
Cdd:COG2814 324 LAPPEARGRASGLYNSAFFL 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-345 |
6.50e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 106.73 E-value: 6.50e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 11 SGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMAL 90
Cdd:pfam07690 11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 91 IILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGIL-SSFSYELLFITNAVGAVMAGIFYVR 169
Cdd:pfam07690 91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLaSLFGWRAAFLILAILSLLAAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 170 FFRKRHKIYQKKMKEKPIVKETLEKErspYRDSPFLVYCLLCAIFSVCFFQFFNTIPIfYKEVAHLDQKSIGYILGYSGF 249
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIVAWKA---LLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 250 IIVVLEMLVVNFADKY--LTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQG 327
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERG 326
|
330
....*....|....*...
gi 1154496064 328 AYMGLNGMTFSISFIITP 345
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
2-376 |
3.67e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.81 E-value: 3.67e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPI 81
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 82 FTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS---FSYELLFITNAV 158
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 159 GAVMAGIFYVRFFRKRHKIYQKKMKEKPIvKETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQK 238
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASS-KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 239 SIGYILGYSGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITA 318
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1154496064 319 LRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVASD-LGFNTLWIGSGAVLALAAIAMY 376
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
2-377 |
1.63e-20 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 91.49 E-value: 1.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINR-SGSMVLPFLGVYMTDQLEF--SIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLL 78
Cdd:cd17330 1 LFLVVFLDAlGFGIVFPVLPFYVREFNKLgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 79 IPIFTSVEGMALIILVQSIISESFRPANSVaITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNAV 158
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAY-IADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 159 GAVMAGIFYVRFFRKrhkiyqkkmkekpivketlekerspyrdsPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQK 238
Cdd:cd17330 160 ALALLNLVLVLFFLP-----------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 239 SIGYILGYSGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITA 318
Cdd:cd17330 211 QIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLS 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1154496064 319 LRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMYF 377
Cdd:cd17330 291 KSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
35-377 |
3.96e-20 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 90.75 E-value: 3.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 35 GIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFT-----SVEGMALIILVQSIISESFRPANSVA 109
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 110 ITKYARPENLTRAFSLNRMAINLGFSIGPALGGIL-SSFSYELLFITNAVGAVMAGIFYvrFFRKRHKIYQKKMKEKPIV 188
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGAFAINALSFLLSALLL--LFIRRPPPAAPGESSSLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 189 KETLEKERSpYRDSPFLVYCLLCAIFSVCFFQFFNT-IPIFYKEVAHLDQKSIGYILGYSGFIIVVLeMLVVNFADKYLT 267
Cdd:cd06173 195 RDLREGLRY-LRRSPLLRLLLLALALFALLGGALTVlLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSKRRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 268 IAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGLNGMTFSISFIITPLL 347
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
330 340 350
....*....|....*....|....*....|
gi 1154496064 348 GTSVASDLGFNTLWIGSGAVLALAAIAMYF 377
Cdd:cd06173 353 AGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-377 |
1.24e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 89.55 E-value: 1.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 13 SMVLPFLgVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALII 92
Cdd:cd17474 16 SIVDPIL-PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 93 LVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNAVGAVMAGIFYVRFFR 172
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 173 KRHKiyqkkmKEKPIVKETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSIGYILGYSGFIIV 252
Cdd:cd17474 175 EPKE------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 253 VLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGL 332
Cdd:cd17474 249 LGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1154496064 333 NGMTFSISFIITPLLGTSVASDLGFNTLWIgSGAVLALAAIAMYF 377
Cdd:cd17474 329 YNFVRFLGQAVGPLLFGLLLEIFGLSAPFL-VGAAIALAAAVLLA 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-379 |
2.21e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 82.61 E-value: 2.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIP 80
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGG-ILSSFSYELLFITNAVG 159
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGwLLAAFGWRAAFLILGLP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 160 AVMAGIFyvrffrkrhkiyqkkmkekpivketlekerspyrdsPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKS 239
Cdd:COG2271 174 GLLLALL------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 240 IGYILGYSGFIIVVLEMLVVNFADKYLTIAK-TLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITA 318
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154496064 319 LRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMYFVV 379
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-379 |
5.21e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 78.79 E-value: 5.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 14 MVLPFLGVYMTDqLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALIIL 93
Cdd:cd17489 14 LLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 94 VQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS-FSYELLFITNAVGAVMAgiFYVRFFR 172
Cdd:cd17489 93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhLGFAVLFIVAAVLALLA--LLLVFLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 173 KRHKIYQKKMKEKPivketlEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHldqKSIGYILGYSGFIIV 252
Cdd:cd17489 171 KDPPPVAAEEAEAG------TRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 253 VLEMLVVNFADKYLTIaKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGL 332
Cdd:cd17489 242 LSRPFSGKLSDRKGPK-TVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1154496064 333 NGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMYFVV 379
Cdd:cd17489 321 FFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
1-378 |
1.57e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 74.53 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIP 80
Cdd:COG2223 9 LATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGG-ILSSFSYELLFITNAVG 159
Cdd:COG2223 89 LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLILGIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 160 AVMAGIFYVRFFRKRHKiyqkkmKEKPIVKETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKS 239
Cdd:COG2223 169 LLVVAVLAWLFLRDPPA------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 240 IGYILGYSGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITAL 319
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 320 RSGKTNQGAYMGLNGMTFSI-SFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMYFV 378
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLgGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
15-378 |
1.76e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.15 E-value: 1.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 15 VLPFLGVYMTDQLEFSIKesgIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSApLFLLIPIFTsvEGMALII-- 92
Cdd:cd17473 21 ALPAIAQHFVPNSELLVP---LLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYG-IGGVAGLFL--DSLYALLas 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 93 -LVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNAVGAVMAgIFYVRFF 171
Cdd:cd17473 95 rALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVL-ILVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 172 RKRhkiyQKKMKEKPIVKETLEKERSPyrdSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSIGYILGYSGFII 251
Cdd:cd17473 174 PEP----ARKSKSAASPGAATAAALPW---KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 252 VVLEMLVVNFAdKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMG 331
Cdd:cd17473 247 AIGALLFGRLK-RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1154496064 332 LNGMTFSISFIITPLL-GTSVASDLGFNTLWIGSGAVLALAAIAMYFV 378
Cdd:cd17473 326 IVTSAFFLGQFLSPLVlGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
1-378 |
2.57e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 70.29 E-value: 2.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIP 80
Cdd:cd17319 7 LLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGG-ILSSFSYELLFITNAVG 159
Cdd:cd17319 87 FATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGwLLLLFGWRWAFIIEGLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 160 AVMAGIFYVRFFRKrhkiyqkkmkekpivketlekerspyrdspFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKS 239
Cdd:cd17319 167 GLLLAVLWWFYLRQ------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 240 IGYILGYSGFIIVVLEMLVVNFADKYLTIAKTLLYGILLC--AVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTIT 317
Cdd:cd17319 217 VGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLlaAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLP 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1154496064 318 ALRSGKTNQGAYMGLNGMTFSISFIITPLL-GTSVASDLGFNTLWIGSGAVLALAAIAMYFV 378
Cdd:cd17319 297 ADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
2-165 |
3.32e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 70.27 E-value: 3.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPI 81
Cdd:cd17324 204 YLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 82 FTSVEGMALIILVQSIISESFRPANSVAITKYArPENLTRAFSLNRMAINLGFSIGPALGG-ILSSFSYELLFItnaVGA 160
Cdd:cd17324 284 GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGlVLDHGGWAGVGW---VGA 359
|
....*
gi 1154496064 161 VMAGI 165
Cdd:cd17324 360 ALLLL 364
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
15-377 |
3.40e-13 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 70.36 E-value: 3.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 15 VLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPiFTSVEGMALI-IL 93
Cdd:cd17388 21 VLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMA-FAPTLWWLYLgRI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 94 VQSIISESFRPANSVaITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNAVGAVMAGIFYVRFFRK 173
Cdd:cd17388 100 IAGITGATGAVAAAY-IADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 174 RHKIYQKKMKEK-------PIVKETLEKERSPYRDSPFLVYCLLCAIFSvcffqffnTIPIFYKEVAHLDQKSIGYILGY 246
Cdd:cd17388 179 SLPPERRRAFRWrranpfgSLRWLTGFPGLLGLLAVFFLIQLIGQVPAT--------TWVLFTEDRFDWSPTMVGLSLAV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 247 SGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEIlVLPFMSTITALRSGKTNQ 326
Cdd:cd17388 251 FGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGI-AGPALQGLLSRQVPENEQ 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1154496064 327 GAYMGLNGMTFSISFIITPLLGTSV--ASDLGFN-TLWIGSGAVLALAAIAMYF 377
Cdd:cd17388 330 GELQGVLTSLTSLTSIIGPLLFTGIfaASPATWPgLAWIIGAALYLICLVLAYR 383
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
6-375 |
8.78e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.80 E-value: 8.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 6 MLINRSGSMV---LPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIF 82
Cdd:cd17475 2 TLAQAAASLVaqgIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 83 TSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPA-LGGILSSFSYELLFITNAVGAV 161
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAlLPPLALHYGWRAAFVVAGLVSI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 162 MAGIFYVRFFRKrhkiYQKKMKEKPIVKETLEKERSPYRDSPFLVYCLlcAIFSVCFFQF-FNT-IPIFYKEVAHLDqks 239
Cdd:cd17475 162 LAAVLFWLFYRE----PPAASAATESASTLLRSLKEVLRNRDVWLIAI--AGALLVAPQFaLLTfLLLFLHDHLGLS--- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 240 igyiLGYSGFIIVVLEMLVV------------NFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEI 307
Cdd:cd17475 233 ----VVAAGALLAVAQLGGAlgriglgrvsdrVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAI 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154496064 308 LVLPFMSTITALRSGKTNQGAYMGL-NGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAM 375
Cdd:cd17475 309 GWNGLYLTLVAESAGPEQAGTALGLaNTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-176 |
1.28e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 68.36 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 4 IVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYR--VQSTSLFLSAPLFLLIPI 81
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLAL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 82 FTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGG-ILSSFSYELLFITNAVGA 160
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAALA 347
|
170
....*....|....*.
gi 1154496064 161 VMAGIFYVRFFRKRHK 176
Cdd:COG2271 348 LLAALLALLLLRETRK 363
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-385 |
4.62e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.23 E-value: 4.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 6 MLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITD----KFGEYRVqstSLFLSAPL----FL 77
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRP---WILIGAIPlalsFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 78 LIPIFTSVEGMALII----------LVQSIISESFRpANSVAITkyARPENLTRAFSLNRMAINLGFSIGPALGGILSSF 147
Cdd:COG2211 97 LLFTAPDLSPTGKLIyalvtylllgLAYTLVNIPYS-ALGAELT--PDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 148 -------SYELLFITNAVGAVMAGIFYVRFFRKRHKIYQKKMKEKPIVKETLekerspyRDSPFLVYCLLCAIFSVCFFQ 220
Cdd:COG2211 174 fggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALL-------KNRPFLLLLLAYLLFFLALAL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 221 FFNTIPIFYKEVAHLDQKSIGYILGySGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAI--NHHIALLLLS 298
Cdd:COG2211 247 VAALLLYYFKYVLGLSAALVGLLLA-LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 299 ISLLSVGEILVLPFMSTITA-------LRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNtlwigSGAVLALA 371
Cdd:COG2211 326 AALAGIGLGAILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYV-----AGAAQSPS 400
|
410
....*....|....
gi 1154496064 372 AIAMYFVVNWLLPG 385
Cdd:COG2211 401 ALTGIRLLFFLLPA 414
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
2-292 |
1.05e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 65.65 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKfgeyRVQSTSLFLSAPLFLLIpi 81
Cdd:cd17471 2 LLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDR----GGDRKPLILLALLAGAL-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 82 ftsveGMALIILVQS-----IISESFRPANSVAITK---YAR-------PENLTRAFSLNRMAINLGFSIGPALGG-ILS 145
Cdd:cd17471 76 -----GYLLFAFLRNywvllLVGVVLLSLGAAAFPQlfaLAReyadrssGRDATLFNSVLRAAFSLAWVIGPPLAFlLLD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 146 SFSYELLFITNAVGAVMAGIFYVRFFRKRHKiyqkkmkeKPIVKETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTI 225
Cdd:cd17471 151 VLGFTGLFLLAALLYLVVALLVLFLLPSVKP--------PAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAM 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154496064 226 PIFYKEVAHLDQKSIGYILGYSGFIIVVLeMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHI 292
Cdd:cd17471 223 PLYVTNELGGSESWVGLLFGLAAALEIPI-MLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSL 288
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-133 |
1.62e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.00 E-value: 1.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 4 IVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFT 83
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG 294
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1154496064 84 SVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLG 133
Cdd:COG2814 295 SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
15-377 |
2.74e-11 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 64.55 E-value: 2.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 15 VLPFLgvymTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGeYRVQSTSLFLSAPLFLLIPIFTSVEGMALIILV 94
Cdd:cd17331 22 VLPYL----TKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFG-PRAALVLSFLSSALSYLLLAFASSVPMLFLSRL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 95 QSIISESFrPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS-FSYELLFITNAVGAVMAGIFYVRFFRK 173
Cdd:cd17331 97 PSVFMHAM-QAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKkFGEQAAALVAAVGSLLSIVLVILLIPS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 174 RHKIYQKKMKEK-------PIVKETLEKERSPYrdSPFLVYCLLCAIFSVCFFQFfnTIPIFYKEVAHLDQKSIGYILGY 246
Cdd:cd17331 176 NTKSKREKEAKEsasppsvFNLKEILRLLRLPG--VAFLLLVKLLSGLPIGMFQS--MFSLVAMDFFGLTPEENGYLMSY 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 247 SGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQ 326
Cdd:cd17331 252 AGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDT 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1154496064 327 GAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMYF 377
Cdd:cd17331 332 GTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
1-288 |
3.26e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.05 E-value: 3.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGvYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFL--------- 71
Cdd:cd17320 4 LALLVALGPLAIDMYLPALP-AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLfilasllca 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 72 ---SAPLFLLIPIFTSVEGMALIILVQSIISESFRPansvaitkyarpENLTRAFSLNRMAINLGFSIGPALGG-ILSSF 147
Cdd:cd17320 83 lasSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSG------------AELAKIFSLLMMILAIAPALAPLLGGlLLLFF 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 148 SYELLFITNAVGAVMAGIFYVRFFRKRhkiyQKKMKEKPIVKETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPI 227
Cdd:cd17320 151 GWRAIFVFLALLGLLLLLLVLLFLPET----LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPF 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154496064 228 FYKEVAHLDQKSIGYILGYSGFIIVVLEMLVVNFADKYlTIAKTLLYGILLCAVAYAMLAI 288
Cdd:cd17320 227 IYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF-GPRRLLRLGLLLLLAAALVLLL 286
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-375 |
1.34e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.10 E-value: 1.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 30 SIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALIILVQSIISESFRPANSVA 109
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 110 ITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS-FSYELLFITNAVGAVMAGIFYVRFFRKRhkiyqkkMKEKPIV 188
Cdd:cd17324 112 AADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLLPSL-------PPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 189 KETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSIGYILGYSGFIIVVLEMLVVNFADKYLTI 268
Cdd:cd17324 185 LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 269 AkTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTItALRSGKTNQGAYMGLNGMTFSISFIITPLLG 348
Cdd:cd17324 265 A-LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAALG 342
|
330 340
....*....|....*....|....*..
gi 1154496064 349 TSVASDLGFNTLWIGSGAVLALAAIAM 375
Cdd:cd17324 343 GLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
1-170 |
2.73e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.97 E-value: 2.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWL-GGYITDKFGEYRVQSTSLFLSAPLFLLI 79
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 80 PIFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNAVG 159
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
|
170
....*....|.
gi 1154496064 160 AVMAGIFYVRF 170
Cdd:cd17330 339 LLLIALFLLSL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
1-170 |
4.30e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.63 E-value: 4.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIP 80
Cdd:cd06173 213 LLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS-FSYELLFITNAVG 159
Cdd:cd06173 293 LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLAGAL 372
|
170
....*....|.
gi 1154496064 160 AVMAGIFYVRF 170
Cdd:cd06173 373 LLLAALLLLLL 383
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
2-375 |
1.31e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGS-MVLPFLGVYMTDqLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEY-RVQSTSLFLSAPLFLLI 79
Cdd:cd17370 4 LGLVSLFADISYeMARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 80 PIFTSVEGMALIILVQSIiSESFR-PANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGIL---SSFSYELLFIT 155
Cdd:cd17370 83 ALAGSWQLVLLLRILERL-GKGIRtPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlylLGGNYRTIFLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 156 NAVGAVMAgIFYVRFFRKRhkiYQKKMKEKPIVKETLEKERSPyrdsPFLVYCLLCAIFSvcFFQFFNTIPIFYKEVAHL 235
Cdd:cd17370 162 AAIPALLA-LLILLFVVKE---YPRPPKLRKKSKKTSLKKLPK----AFWLYLLAVALFA--LGNFSFAFLILRAQELGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 236 DQKSIgyILGYSGFIIV--VLEMLVVNFADKYlTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFM 313
Cdd:cd17370 232 SAALI--PLLYALFNLVyaLAAYPAGRLSDRI-GRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIE 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1154496064 314 STITALRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAM 375
Cdd:cd17370 309 RAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
13-378 |
3.56e-08 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 54.54 E-value: 3.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 13 SMVLPFLGVYMTDqLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVegmaLII 92
Cdd:cd17390 13 SMILPLLSTHIRS-LGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSL----ALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 93 LVQSIISESFRPANSVA---ITKYARPENLTRAFSLNRMAINLGFSIGPALGGILS---------SFSYELLFITNAVGA 160
Cdd:cd17390 88 FLSRIPLGIFKHTQSLCkayLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAetdggfyyvALLCSAIFILNAGLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 161 VMAGIFYVRFFrkrhkiyqkkmkekpivketlekerspyrdspflvycLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSI 240
Cdd:cd17390 168 WFLLSKLWDLL-------------------------------------LVRFLMGFSVLLFRSNFSLYLEERFDLSPKTI 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 241 GYILGYSGFIIVVLEMLVVNFADKYLTIAKTLLYG--ILLCAVAYAML---AINHHIALLLLSISLLSVGEILvlpfMST 315
Cdd:cd17390 211 GYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHsfILLALSLLGLAlapSIWLLVLCLTPLSISSAVLRTC----STS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1154496064 316 ITALRSGKTNQGAYMGLNGMTFSISFIITPLLGtSVASDLGFNTLWIGSGAVLALAAIAMYFV 378
Cdd:cd17390 287 LLLSRGKSKERGTLLGVGQSVTSLARILAPLLS-GLLQEFSVSGPGLLGAVLALAAILLMLAR 348
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
2-288 |
3.97e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.48 E-value: 3.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPI 81
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 82 FTSVEGMALIILVQSIISESFRPANSVAITKYArPENLTRAFSLNRMAINLGFSIGPALGG-ILSSFSYELLFITNAVGA 160
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAaLVALFGGLGLLILLIIPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 161 VMAGIFYVRFFRKRHKIYQKKMKEKPIvketlekeRSPYRDSPFLVYCLLCAIFSVCFFQF-FNT-IPIFYKEV------ 232
Cdd:cd17478 160 LAVALLLLRLRPLKKPEAKKAAAKSSA--------RSTLKGVWRALLLLLIIVFLRSWVLSsLTTfLPFYLVQRgyslvf 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154496064 233 ------AHLDQKSIGYILG-------------YSGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAI 288
Cdd:cd17478 232 aglllsLFLFAGAIGTLIGgplsdrfgrrrviIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVL 306
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
19-381 |
4.11e-08 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 54.50 E-value: 4.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 19 LGVYMTDQL--EFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRvqsTSLFLSAPL----FLLIPIFTSVEGMALII 92
Cdd:cd17346 25 LILYLTAQLgdGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGAR---RTVFIGGILmalgYLLLALSPFSVSMLYLG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 93 LVQSIISESFRPANSVAITKYARPENLTR---AFSLNRMAINLGFSIGPALGGILSS-FSYELLFITNAVGAVMAGIFYV 168
Cdd:cd17346 102 LALIIVGNGLFKPNISSLVGKLYDENDPRrdsGFSIFYMGINLGAFLAPLLCGTLGDnYGYHYGFGLAAVGMLLGLLIFL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 169 rfFRKRHKIYQKKMKekpivketlekerspyrdsPFLVYCLLCAIFSVCFFQFFNTIPIFYKEvaHLDQKSIGYILGYSG 248
Cdd:cd17346 182 --LGRKKLLERKKML-------------------AIIILFLFAVVFWAIYEQAGTSLALFADE--NVDRLLGGFTIPPSW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 249 F------IIVVLEMLVVNF------ADKYLTIAKTLLYGILLCAVAY------AMLAINHHIALLL---LSISLLSVGEI 307
Cdd:cd17346 239 FqslnplFIILLAPILAALwtklgkRGKDPSIPTKFALGLLLLGLSFllmvlaASFAGGSGKVSALwlvLSYFLQTLGEL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 308 LVLPF-MSTITALRSGKTnQGAYMGLNGMTFSISFIITPLLGTSVASD-------LGFNTLWIGSGAVLALAAIAMYFVV 379
Cdd:cd17346 319 CLSPVgLSMITKLAPAKF-AGFMMGLWFLASALGNILAGYLAGFYAQPkdplasaLVYTDYFGLIGVIALVAGIILLLLA 397
|
..
gi 1154496064 380 NW 381
Cdd:cd17346 398 KK 399
|
|
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
3-174 |
6.29e-08 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 53.98 E-value: 6.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 3 SIVMLINRSGSmvLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIF 82
Cdd:PRK10054 16 SLLLTIGRGAT--LPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 83 TSVegmALIILVQSIISESFRPANSVAITKYArpENLT-----RAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNA 157
Cdd:PRK10054 94 NNV---TLVVLFFALINCAYSVFSTVLKAWFA--DNLSstsktKIFSLNYTMLNIGWTVGPPLGTLLVMQSINLPFWLAA 168
|
170
....*....|....*..
gi 1154496064 158 VGAVMAgIFYVRFFRKR 174
Cdd:PRK10054 169 ICSAFP-LVFIQIWVQR 184
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
2-375 |
7.49e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 7.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGSMVLPFLGVYMTDQlEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPI 81
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 82 FTS---------VEGMALIILvqSIISESfrpansvAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELL 152
Cdd:cd17477 81 TDSpwvwfllrfVMGIGLAGL--FVVSES-------WLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 153 FItnAVGAVMAGIFYVRFFRKrhkiyqkkmKEKPIVKETLEKERSPYRDSPF-LVYCLLCAIFSVCFFQFFntiPIFYKE 231
Cdd:cd17477 152 LI--AAVLLLLALVPLLLTRR---------AAPEIEEAESISLRRLLRIAPLaLLGAFVAGFLEGAFYSLL---PLYGLR 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 232 VaHLDQKSIGYILGYSGFIIVVLEMLVVNFADKYltiAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLP 311
Cdd:cd17477 218 L-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRF---DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGP 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154496064 312 FMSTITALRSGKTNQGAYMGLNG---MTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAM 375
Cdd:cd17477 294 LYTLALALAGDRLPGDELVAANAallLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
23-174 |
1.60e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 23 MTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALIILVQSIISESF 102
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1154496064 103 RPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGIL-SSFSYELLFITNAVGAVMAGIFYVRFFRKR 174
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLvAALGWRWIFLINAPLGLLALVLRLRLPESR 192
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
18-166 |
1.86e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.56 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 18 FLGVYMTDQLeFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALIILVQSI 97
Cdd:cd17478 217 FLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFL 295
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1154496064 98 ISESFrpANSVAITKYARPENLTRAfslNRMAINLGFSIG----PALGGILSSFSYELLFITNAVGAVMAGIF 166
Cdd:cd17478 296 LFASF--PVTVVLAQELLPGNVGLA---SGLMMGLSFGLGgigaPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
208-379 |
3.34e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 3.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 208 CLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSIGYILGYSGFIIVVLEMLVVNFADKYLTiAKTLLYGILLCAVAYAMLA 287
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR-RRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 288 INHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAV 367
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|..
gi 1154496064 368 LALAAIAMYFVV 379
Cdd:pfam07690 161 SLLAAVLLLLPR 172
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
1-171 |
3.36e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 51.88 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKE---SGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFL 77
Cdd:cd17391 206 LFVTTFIIQLANQSIEPILTLYIRQLMGDASNLafiSGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYI 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 78 LIPIFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS-FSYELLFITN 156
Cdd:cd17391 286 PQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAhFGYRAVFVVT 365
|
170
....*....|....*
gi 1154496064 157 AVGAVMAGIFYVRFF 171
Cdd:cd17391 366 ALLVLLNAIWSFIFL 380
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
14-333 |
5.11e-07 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 51.21 E-value: 5.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 14 MVLPFLGVYMTDQLEFSIKESGIVLsfyGVGSVIGSWLG---GYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSvegmAL 90
Cdd:PRK11646 28 VVFPLISIRFVDQLGWAAVMVGIAL---GLRQFIQQGLGifgGAIADRFGAKPMIVTGMLMRAAGFATMAIAHE----PW 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 91 IILVQSIIS----ESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNAVGAVMAGIF 166
Cdd:PRK11646 101 LLWLSCILSglggTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLAAAF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 167 YVrFFRKRHKIYQKKMkekPIvketLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHlDQKSIGYILGY 246
Cdd:PRK11646 181 NA-WLLPAYKLSTVRT---PV----REGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG-SPSAVKWMYAI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 247 SGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQ 326
Cdd:PRK11646 252 EACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARETLSASLADARAR 331
|
....*..
gi 1154496064 327 GAYMGLN 333
Cdd:PRK11646 332 GSYMGFS 338
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-377 |
1.10e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.24 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 22 YMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALIILVQSIISES 101
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 102 FRPA-NSVAITKYarPENLTRAFSLNRMAINLGFSIGPALGG--ILSSFSYELLFITNAVGAVMAGIFYVRFFRKRHKIy 178
Cdd:COG0738 113 LDVAaNPYVAALG--PETAASRLNLLHAFFSLGALLGPLLGGllILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEI- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 179 qkkMKEKPIVKETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSIGYILGYSGFIIVVLeMLV 258
Cdd:COG0738 190 ---EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIG-RFL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 259 VNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGLNGMTFS 338
Cdd:COG0738 266 GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIV 345
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1154496064 339 ISFIITPLLGtSVASDLGFNT-LWIGSGAVLALAAIAMYF 377
Cdd:COG0738 346 GGAIGPPLIG-FLADAFGLRAaFLVPLVCYLLILLLALAL 384
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
17-146 |
1.57e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 49.54 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 17 PFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALIIL--V 94
Cdd:cd17318 41 KDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLriL 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1154496064 95 QSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS 146
Cdd:cd17318 121 QGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCE 172
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
4-171 |
5.86e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 5.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 4 IVMLINRSGSMVLPFLGVYMTDQLefsIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSApLFLLIPIFT 83
Cdd:cd17489 202 ILFLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLA-LGLLLLSFA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 84 SVEGMALIILVQSIISE-SFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGIL-SSFSYELLFITNAVGAV 161
Cdd:cd17489 278 GSPWMLLLAAVLYGLGFgLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVaELFGYRAMFLLAAVVVL 357
|
170
....*....|
gi 1154496064 162 MAGIFYVRFF 171
Cdd:cd17489 358 LALVLYIFLL 367
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
34-375 |
8.42e-06 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 47.59 E-value: 8.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 34 SGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQS-TSLFLSAP---LFLLIPIFTSveGMALIILVQSIISeSFRPANSVA 109
Cdd:cd17326 38 FGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLiVSILIAIVgniLYALAEYFPS--NRKYVMLVARFLI-GVGAGNVAV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 110 ITKYA----RPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITN----------AVGAVMAGIFYVRFFrkrh 175
Cdd:cd17326 115 LRAYVaaasTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPGYVIGIklrfnmytapAWLMAILGIINIILI---- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 176 kiyqkkmkeKPIVKEtlekerspyrdspflVYCLLCAIFSVCFFQFFNTI-PIFYKEVAHLDQKSI----GYILGYSGFI 250
Cdd:cd17326 191 ---------LFFFKE---------------VVCIFLFFVVLFIFANLETIgTPLTMDMYGWTREEAvlynGIILAVSGVL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 251 IVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLaINHHIALLLLSISLLSVGEILVLPFMSTITalrsGKTNQGAYM 330
Cdd:cd17326 247 SVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT-LPWGITGVILFGLGYPIGNVMLYTLYSKIL----GPKPQGTMQ 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1154496064 331 GLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAM 375
Cdd:cd17326 322 GVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILL 366
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
18-167 |
8.79e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.16 E-value: 8.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 18 FLGVYMTDQLeFSIKESGIVLSFYGVGSVIGSWLGGYITDK--FGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALIILVQ 95
Cdd:cd17352 205 YLPSYAKSLG-IDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLF 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1154496064 96 SIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGIL--SSFSYELLFITNAVGAVMAGIFY 167
Cdd:cd17352 284 GFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLrdYTGDYDAAFYFCGACLLLSGVLL 357
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
3-144 |
9.19e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.19 E-value: 9.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 3 SIVMLINRSGSMVLPFL-GVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPI 81
Cdd:cd17503 184 LLLSFLLGLGLFGAMFLlPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAF 263
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154496064 82 FTSVEGMALIILVQSI----ISESFRPANSVAItKYARPENLTRAFSLNRMAINLGFSIGPALGGIL 144
Cdd:cd17503 264 LTPDTSLWLIILPLFIrglgMGLVFMPLNTLAL-NSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
4-149 |
1.11e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.17 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 4 IVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIF- 82
Cdd:cd17321 176 AAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLg 255
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154496064 83 --TSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSY 149
Cdd:cd17321 256 adSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGL 324
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-176 |
2.39e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 2.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 11 SGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSA-PLFLLIPIFTSVEGMA 89
Cdd:COG2223 220 SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAlGLLLLALALGSLWLFL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 90 LIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSF--SYELLFITNAVGAVMAGIFY 167
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLT 379
|
....*....
gi 1154496064 168 VRFFRKRHK 176
Cdd:COG2223 380 LLLYRRPRR 388
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-166 |
2.98e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 14 MVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALIIL 93
Cdd:cd17473 215 VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAI 294
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154496064 94 VQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILS------SFSYELLFITNAVGAVMAGIF 166
Cdd:cd17473 295 LAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVnltgglSGAFLILGVLALVLAIVLLLL 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-185 |
3.48e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSApLFLLIP 80
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA-LGLLLL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVEGMALIILVQSIISESFRPANSVA------ITKYARPENLTRA----FSLNRMAINLGFSIGPALGG-ILSSFSY 149
Cdd:COG2211 312 FFLGPGNLWLLLVLAALAGIGLGAILVLPwamladVVDYDEWKTGRRReglyFGIFTFAIKLGQALAGALAGlLLALFGY 391
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1154496064 150 E---------------LLFITNAVGAVMAGIFYVRFF--RKRHKIYQKKMKEK 185
Cdd:COG2211 392 VagaaqspsaltgirlLFFLLPAVLLLLAALLLLFYPltRERHAEIRAELAAR 444
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
13-183 |
4.11e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.37 E-value: 4.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 13 SMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALII 92
Cdd:cd17371 15 LLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 93 LVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSS-----FSYELLFITNAVGAVMagIFY 167
Cdd:cd17371 95 ALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppeIAWRVLFLLGALPALL--VLF 172
|
170
....*....|....*.
gi 1154496064 168 VRFFRKRHKIYQKKMK 183
Cdd:cd17371 173 IRRFVKEPPQWQAARA 188
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
2-291 |
5.40e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 5.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSG-SMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIP 80
Cdd:cd17472 1 LSLIFSLRMLGmFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVEGMALIILVQ---SIISesfrpANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSF--SYELLFIT 155
Cdd:cd17472 81 YATSIYGLILGRALQgsgAISS-----VVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHlgVSGLFLIT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 156 NAVGAVmaGIFYVRFFRKR-HKIYQKKMKEKPIVKETLekerspyRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAH 234
Cdd:cd17472 156 AILSLV--SLLILLFFVPDpPKIVQISEKEKKKLKKLL-------KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGG 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1154496064 235 lDQKSIGYILGYSGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHH 291
Cdd:cd17472 227 -GKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAAT 282
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
1-172 |
8.73e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 44.08 E-value: 8.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIP 80
Cdd:cd17380 3 LLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 81 IFTSVeGMALIILVQSI--ISESFR-PANSVAITKYARPENLTRAFSLnrmaINLGFSIGPALGGILSS-----FSYELL 152
Cdd:cd17380 83 LLAYS-SLPLLILSRILlgLGEGVHfPSMTSLFSRWVPVSERSRAVSI----VTAGSYLGTLLGGLIGPllleyYGWPSV 157
|
170 180
....*....|....*....|
gi 1154496064 153 FITNAVGAVMAGIFYVRFFR 172
Cdd:cd17380 158 FYFFGLLGLLWALVWLIYLP 177
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-176 |
1.09e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.07 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 18 FLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIpIFTSVEGMALIILV--- 94
Cdd:COG0738 232 WLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA-LLAPGPWLALIGLAlvg 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 95 ----------QSIISESFRPANSVAITkyarpenltrafSLNRMAInLGFSIGPALGGILS-SFSYELLFITNAVGAVMA 163
Cdd:COG0738 311 lglslmfptiFSLALDGLGKRTAAAVS------------AVLIMGI-VGGAIGPPLIGFLAdAFGLRAAFLVPLVCYLLI 377
|
170
....*....|...
gi 1154496064 164 GIFYVRFFRKRHK 176
Cdd:COG0738 378 LLLALALKRKRRK 390
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
51-291 |
1.25e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.72 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 51 LGGYITDKFGEYRVQSTSLFL------------SAPLFLLIPIFTSVEGMALIILVQSIISESFRPansvaitkyarpEN 118
Cdd:cd17503 50 LSGWLADRFGTRRLFLTALALftlgsllcglapNLASLIIFRILQGFGGGVLIPLAQTILLRIYPP------------EK 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 119 LTRAFSLNRMAINLGFSIGPALGGILS-SFSYELLFITN----AVGAVMAGIFYVRFFRKRHkiyqkkmkekpivketle 193
Cdd:cd17503 118 RGAAMGLVGLVILLAPAIGPTLGGWLTdNLSWRWIFYINlpigILALLLAPLLDLRLFKDRN------------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 194 kerspyrdspFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSIGYILGYSGFIIVVLEMLVVNFADKYLTiAKTLL 273
Cdd:cd17503 180 ----------FTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGP-RLLLL 248
|
250
....*....|....*...
gi 1154496064 274 YGILLCAVAYAMLAINHH 291
Cdd:cd17503 249 AGLLLLALGTLLLAFLTP 266
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
35-284 |
1.31e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 43.96 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 35 GIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIfTSVEGMALIIL---VQSIISESFRPANSVAIT 111
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPW-AAGGGIALVVFcrvIQGLAQGSVSPATHKIIV 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 112 KYARPENLTRAFSLNRMAINLGFSIGPALGGIL--SSFSYELLF-ITNAVGAVMAGIFYVRFFRKRHKIYQKKMKEKPIV 188
Cdd:TIGR00894 158 KWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLceSWGGWPMIFyVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYI 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 189 KETLEKERSPYRDS-PFL-------VYCLLCAIFsvCFFQFFNTI----PIFYKEVAHLDQKSIG------YILGY-SGF 249
Cdd:TIGR00894 238 NSSLQGQKGSTRQSlPIKaipkslpVWAIWFAIF--GHFWLYTILptylPTFISWVLRVSGKENGllsslpYLFAWlCSI 315
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1154496064 250 IIVVL-------EMLVVNFADKYLTIAKTLLYGILLCAVAYA 284
Cdd:TIGR00894 316 FAGYLadflkssKTLSLTAARKIFNGIGGLGPGIFAYALPYL 357
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
23-378 |
2.11e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.93 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 23 MTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEgmALII--LVQSIISE 100
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA--FLIAarALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 101 SFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGIL-SSFSYELLFITNAVGAVmAGIFYVRffrkrhkiyq 179
Cdd:cd17321 100 AIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLlELFGWRWIFLINVPIGL-VALLLAR---------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 180 kkmkekpivketlekerspyrdsPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSIGYILGYSGFIIVVLEMLVV 259
Cdd:cd17321 169 -----------------------TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 260 NFADKYlTIAKTLLYGILLCAVAYAMLAI---NHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGLNGMT 336
Cdd:cd17321 226 RLADRF-GPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTA 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154496064 337 FSISFII-TPLLGT----------------------SVASDLGFNTLWIGSGAVLALAAIAMYFV 378
Cdd:cd17321 305 RQLGGALgVALLGAlltaglsanlgdsgvaallsaaAAAFAAGFHLAFLVAAALALLAALLALLL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
197-379 |
2.62e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 197 SPYRDSPFLVYCLLCAIFSVCFFQFFNTIPiFYKEVAHLDQKSIGYILGYSGFIIVVLEMLVVNFADKYlTIAKTLLYGI 276
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 277 LLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLG 356
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180
....*....|....*....|...
gi 1154496064 357 FNTLWIGSGAVLALAAIAMYFVV 379
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
13-144 |
2.84e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.59 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 13 SMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGS-VIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGMALI 91
Cdd:cd17331 224 GMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGmVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVL 303
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1154496064 92 ILVQSIISESFRPANSVAITKYARPENLTRAFSLNrMAIN-LGFSIGPALGGIL 144
Cdd:cd17331 304 LLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLS-HALFsLVRTVSPTIGGAL 356
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
17-378 |
3.39e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.55 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 17 PFLGVyMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFL------------SAPLFLLIPIFTS 84
Cdd:COG2807 39 PLLPE-IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLlaaglllrslapSVALLLAGTALIG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 85 VeGMALI-ILVQSIISESFrpansvaitkyarPENLTRAFSLNRMAINLGFSIGPALGG-ILSSFSYELLFITNAVGAVM 162
Cdd:COG2807 118 A-GIAVGnVLLPGLIKRWF-------------PDRVGLMTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAVWALLALL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 163 AGIFYVRFFRKRHKiyqkkmkeKPIVKETLEKERSPYRDSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEvAHLDQKSIGY 242
Cdd:COG2807 184 ALLLWLPLLRRRPA--------AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 243 ILGYSGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHiALLLLSISLLSVGEILVLPFMSTITALRSG 322
Cdd:COG2807 255 LLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRAR 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 323 KTNQGAymGLNGMTFSISFIIT---PLLGTSVASDLG-FNTLWIGSGAVLALAAIAMYFV 378
Cdd:COG2807 334 TPAEAA--ALSGMAQSVGYLLAalgPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-138 |
3.84e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 3.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 1 MLSIVMLINRSGSMVLPFLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYR---VQSTSLFLSAPLFL 77
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154496064 78 LIPIFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGP 138
Cdd:pfam07690 284 LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
2-169 |
1.32e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.29 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGsmvlpfLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFG--EYRVQSTSLFLSAPLFLLI 79
Cdd:cd17390 184 MGFSVLLFRSN------FSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKnnEYLLLLHSFILLALSLLGL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 80 PIFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSFSYELLFITNAVG 159
Cdd:cd17390 258 ALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVL 337
|
170
....*....|
gi 1154496064 160 AVMAGIFYVR 169
Cdd:cd17390 338 ALAAILLMLA 347
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
18-147 |
1.42e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 40.45 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 18 FLGVYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSapLFLLIPIFTSVEGMALIILVQSI 97
Cdd:PRK03893 297 LLPTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLIS--QLLIIPVFAIGGANVWVLGLLLF 374
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1154496064 98 ISESFRPANSVAITKYarpenLTRAFSLNRMAINLGFS--IGpALGGILSSF 147
Cdd:PRK03893 375 FQQMLGQGISGLLPKL-----IGGYFDTEQRAAGLGFTynVG-ALGGALAPI 420
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
13-379 |
1.66e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 13 SMVLPFLGVYMTDQLEFSIKE----SGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIFTSVEGM 88
Cdd:cd17391 13 SLIAPFLPLYIEQLGVTSGGLvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 89 ALIILVQSIISeSFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILS-SFSYELLFITNAVGAVMAGIFY 167
Cdd:cd17391 93 LILRLLQGVFS-GYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLAdLFGIRNVFFITGGLLFLAFLLT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 168 VRFFRKRHKIYQKKMKEKPivKETLEKERSPyrdSPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHlDQKSI----GYI 243
Cdd:cd17391 172 LFFVKEDFKPVEKKKMVST--KEVWNSVPNP---SLLISLFVTTFIIQLANQSIEPILTLYIRQLMG-DASNLafisGLV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 244 LGYSGFIIVVLEMLVVNFADKYLTiAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGK 323
Cdd:cd17391 246 FSATGVSSLLSAPRLGKLGDRIGH-HRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPK 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1154496064 324 TNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMYFVV 379
Cdd:cd17391 325 EVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
207-380 |
2.19e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 207 YCLLCAIFSVCFFQFFNTIPIFYKEVaHLDQKSIGYILGYSGFIIVVLEMLVVNFADKYLTiAKTLLYGILLCAVAYAML 286
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 287 AINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVAS--DLGFNTLWIGS 364
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIA 158
|
170
....*....|....*.
gi 1154496064 365 GAVLALAAIAMYFVVN 380
Cdd:cd06174 159 AALALLAAILLLLVVP 174
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-166 |
2.51e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 29 FSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLIPIF-TSVEGMALIILVQSIISESFRPANS 107
Cdd:cd17504 214 LGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLP 293
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1154496064 108 VAITKYARPENLTRAFSLNRMAINLGFSIGPALGG-ILSSFS-------------YELLFITNAVGAVMAGIF 166
Cdd:cd17504 294 NIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGaILTTYTvsitsggvptegaYVLAFLIGAALALAALLL 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
197-379 |
2.88e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 197 SPYRDSPFLVYCLLCAIFSVCFFQFFNtIPIFYKEVA---HLDQKSIGYILGYSGFIIVVLEMLVVNFADKYlTIAKTLL 273
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSN-LSVAAPPLQadlGLSAAQLGLLASAFFLGYALGQIPAGLLADRF-GRRRVLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 274 YGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMSTITALRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVAS 353
Cdd:COG2271 80 IGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180
....*....|....*....|....*.
gi 1154496064 354 DLGFNTLWIGSGAVLALAAIAMYFVV 379
Cdd:COG2271 160 AFGWRAAFLILGLPGLLLALLRFWLL 185
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
2-377 |
2.88e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 2 LSIVMLINRSGSMVLPFLGVYMTDqLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRvqstsLFLSAPLFL---- 77
Cdd:cd17490 2 LIIVFLFWFSQYVYVPFLSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRK-----LFIIIGLLFtvla 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 78 -LIPIFTSVEGMALIILVQSIISESFRPANSVAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILS-SFSYELLFIT 155
Cdd:cd17490 76 sLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 156 NAVGAVMAgiFYVRFFRKRHKiyQKKMKEKPIVKETLekerSPYRDSPFLVYCLLCAI-FSVCFFQFFNTIPIFYKEVAh 234
Cdd:cd17490 156 AALAGVLG--FILSLFIKEER--REKKPVLTELKELL----SVLKDKKLLFFSLLAILqQMITFSTTFGFTPLIAKQLG- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 235 LDQKSIGYILGYSGFIIVVLEMLVVNFADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMS 314
Cdd:cd17490 227 ASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLM 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1154496064 315 TITALRSGKTNQGAYMGLNGMTFSISFIITPLLGTSVASDLGFNTLWIGSGAVLALAAIAMYF 377
Cdd:cd17490 307 SLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
16-169 |
3.79e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 39.22 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 16 LPFlgvYMTDQLEFSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTS-LFLSAPLFLLIPIFTSVeGMALIIlV 94
Cdd:cd17344 234 LPL---YISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAmLILAAPMLFIYNYFGQV-SMTTNI-V 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 95 QSIISESFRPANSVAITKYARPENLT--------RAFSLNRMAIN----LGFSIGPALGGILSSFSYELLFITNAVGAVM 162
Cdd:cd17344 309 LLIVCGLLVNGPYALITTAVSADLGThkslkgnaRALATVTAIIDgtgsIGAALGPLLAGLISSRGWNNVFYMLIAADVC 388
|
....*..
gi 1154496064 163 AGIFYVR 169
Cdd:cd17344 389 AGLLLTR 395
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
19-174 |
5.08e-03 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 38.64 E-value: 5.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 19 LGVYMTDQLE-----FSIKESGIVLSFYGVGSVIGSWLGGYITDKF-GEYRvqstSLFLSAPL-----FLL---IPIFTS 84
Cdd:COG3104 37 LVLYLTASLAdgglgLSEADAAAIYGAYTALVYLTPLLGGWLADRLlGQRR----AILLGGILmalghFLLalpGGVTLF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 85 VEGMALIIL--------VQSIISESFRPANSvaitkyarpeNLTRAFSLNRMAINLGFSIGPALGGIL-SSFSYELLFIT 155
Cdd:COG3104 113 YLGLALIAVgnglfkpnISSLVGQLYDPGDP----------RRDAGFTIFYMGINIGAFLAPLLCGYLgEKYGWHYGFGA 182
|
170
....*....|....*....
gi 1154496064 156 NAVGAVMAGIFYVrFFRKR 174
Cdd:COG3104 183 AAIGMLIGLIIFL-LGRKY 200
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
47-315 |
5.46e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 47 IGSWLGGYITDKFGEYRVQSTSLFLSAPLFLLI---PIFTSVEGMALIILVQSIISESFR-----PANSVAITKYARPEN 118
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIavtPTYATIGIWAPIILLLARLLQGLSvggeyGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 119 LTRAFSLNRMAINLGFSIGPALGGILS---------SFSYELLFITNAVGAVMAgiFYVRffrkrhkiyqKKMKEKP--- 186
Cdd:cd17367 135 RGFYSSFQYVTLIGGQLLALGVLLVLQhtlgedqmaAWGWRIPFLLGGVLAVVV--LWLR----------RGLEETEsfe 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 187 IVKETLEKERSPYRD-----SPFLVYCLLCAIFSVCFFQFFNTIPIFYKEVAHLDQKSIGYILGYSGFIIVVLEMLVVNF 261
Cdd:cd17367 203 AIAESNEASAGTLRElrrhpRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRL 282
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1154496064 262 ADKYLTIAKTLLYGILLCAVAYAMLAINHHIALLLLSISLLSVGEILVLPFMST 315
Cdd:cd17367 283 SDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSI 336
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
29-165 |
6.01e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.41 E-value: 6.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 29 FSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSA-PLFLLIPIFTSVEGMALIILVQSIISESFRPANS 107
Cdd:cd17355 242 ISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRAlGLALLLLLPFPPLALLLFAALFGLGWGATVPLTA 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 108 VAITKYARPENLTRAFSLNRMAINLGFSIGPALGGILSSF--SYELLFITNAVGAVMAGI 165
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRtgSYTAAWALAVALGLIAAL 381
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-165 |
6.77e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.34 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154496064 29 FSIKESGIVLSFYGVGSVIGSWLGGYITDKFGEYRVQSTSLFLSA-PLFLLIPIFTSVEGMALIILVQSIisesFRPANS 107
Cdd:cd17365 203 YSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAvSLALLGVSPASLVLLYVLVFLAGA----CVNGAQ 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154496064 108 VAITKYArpenlTRAFSLNRMAINLGFSIG---------PALGGIL--SSFSYELLFITNAVGAVMAGI 165
Cdd:cd17365 279 VGLYALA-----ARFYPTEVRATGVGWALGvgrlgailgPLLGGLLlaAGLGPESVFLALAIPAALGAL 342
|
|
| |
