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Conserved domains on  [gi|1142881326|gb|AQL27862|]
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hypothetical protein BBD65_17780 [Klebsiella variicola]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 83-357 7.78e-28

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 111.86  E-value: 7.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326  83 DYRVFFFNRILKYSH-----VIYHTSWTKWDGSKYPKQYSFNKKLIlkwwsfFLKHRVNSFAVVTETVKQQLVDNFNIDK 157
Cdd:cd03801    90 GLLAALLAALLALLLgaplvVTLHGAEPGRLLLLLAAERRLLARAE------ALLRRADAVIAVSEALRDELRALGGIPP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 158 SKIVVVYH----SYESSTFNVKTKNKNDKLKAIFVGRLVKEKGVDDLL-AIAKI---NSEVEFIIVG-EGPL-SEHVKIE 227
Cdd:cd03801   164 EKIVVIPNgvdlERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLeALAKLlrrGPDVRLVIVGgDGPLrAELEELE 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 228 AREISNVNVYNFIkDKNKLADLYRESTFILLPSkrtpFWEElFGMVLIEAMACGCIPLCTDHNGPSIILGHST--LKINV 305
Cdd:cd03801   244 LGLGDRVRFLGFV-PDEELPALYAAADVFVLPS----RYEG-FGLVVLEAMAAGLPVVATDVGGLPEVVEDGEggLVVPP 317

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 306 FSEDEYIQSVNAsfkkyqnqphlLVEDR-------INAIA-IAQKYSKESIADFWAAVIK 357
Cdd:cd03801   318 DDVEALADALLR-----------LLADPelrarlgRAARErVAERFSWERVAERLLDLYR 366
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 83-357 7.78e-28

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 111.86  E-value: 7.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326  83 DYRVFFFNRILKYSH-----VIYHTSWTKWDGSKYPKQYSFNKKLIlkwwsfFLKHRVNSFAVVTETVKQQLVDNFNIDK 157
Cdd:cd03801    90 GLLAALLAALLALLLgaplvVTLHGAEPGRLLLLLAAERRLLARAE------ALLRRADAVIAVSEALRDELRALGGIPP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 158 SKIVVVYH----SYESSTFNVKTKNKNDKLKAIFVGRLVKEKGVDDLL-AIAKI---NSEVEFIIVG-EGPL-SEHVKIE 227
Cdd:cd03801   164 EKIVVIPNgvdlERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLeALAKLlrrGPDVRLVIVGgDGPLrAELEELE 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 228 AREISNVNVYNFIkDKNKLADLYRESTFILLPSkrtpFWEElFGMVLIEAMACGCIPLCTDHNGPSIILGHST--LKINV 305
Cdd:cd03801   244 LGLGDRVRFLGFV-PDEELPALYAAADVFVLPS----RYEG-FGLVVLEAMAAGLPVVATDVGGLPEVVEDGEggLVVPP 317

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 306 FSEDEYIQSVNAsfkkyqnqphlLVEDR-------INAIA-IAQKYSKESIADFWAAVIK 357
Cdd:cd03801   318 DDVEALADALLR-----------LLADPelrarlgRAARErVAERFSWERVAERLLDLYR 366
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 181-298 6.48e-20

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 85.40  E-value: 6.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 181 DKLKAIFVGRLVKEKGVDDLL-AIAKI---NSEVEFIIVGEGPLSEHVK--IEAREIS-NVNVYNFIKDKNkLADLYRES 253
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIkAFALLkekNPNLKLVIAGDGEEEKRLKklAEKLGLGdNVIFLGFVSDED-LPELLKIA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1142881326 254 TFILLPSKRtpfweELFGMVLIEAMACGCIPLCTDHNGPSIILGH 298
Cdd:pfam00534  80 DVFVLPSRY-----EGFGIVLLEAMACGLPVIASDVGGPPEVVKD 119
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 249-357 3.33e-09

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 54.23  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 249 LYRESTFILLPSkrtpfWEELFGMVLIEAMACGCIPLCTDHNGPS--IILGHSTLKINVFSEDEYIQSVNasfkKYQNQP 326
Cdd:COG0438    17 LLAAADVFVLPS-----RSEGFGLVLLEAMAAGLPVIATDVGGLPevIEDGETGLLVPPGDPEALAEAIL----RLLEDP 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1142881326 327 HLLVEDRINAIAIAQ-KYSKESIADFWAAVIK 357
Cdd:COG0438    88 ELRRRLGEAARERAEeRFSWEAIAERLLALYE 119
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
140-283 9.79e-07

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 50.09  E-value: 9.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 140 VVTETVKQQLVdNFNIDKSKIVVVYHSYESSTFNVKTKNKNDKLKAIFVGRLV--KEKGVDDLL-AIAKINSEVEFIIVG 216
Cdd:PRK09922  139 AISSGIKEQMM-ARGISAQRISVIYNPVEIKTIIIPPPERDKPAVFLYVGRLKfeGQKNVKELFdGLSQTTGEWQLHIIG 217

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1142881326 217 EGPLSEHVKIEARE--ISN--------VNVYNFIKDKNKladlyrESTFILLPSKRtpfweELFGMVLIEAMACG--CI 283
Cdd:PRK09922  218 DGSDFEKCKAYSRElgIEQriiwhgwqSQPWEVVQQKIK------NVSALLLTSKF-----EGFPMTLLEAMSYGipCI 285
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 83-357 7.78e-28

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 111.86  E-value: 7.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326  83 DYRVFFFNRILKYSH-----VIYHTSWTKWDGSKYPKQYSFNKKLIlkwwsfFLKHRVNSFAVVTETVKQQLVDNFNIDK 157
Cdd:cd03801    90 GLLAALLAALLALLLgaplvVTLHGAEPGRLLLLLAAERRLLARAE------ALLRRADAVIAVSEALRDELRALGGIPP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 158 SKIVVVYH----SYESSTFNVKTKNKNDKLKAIFVGRLVKEKGVDDLL-AIAKI---NSEVEFIIVG-EGPL-SEHVKIE 227
Cdd:cd03801   164 EKIVVIPNgvdlERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLeALAKLlrrGPDVRLVIVGgDGPLrAELEELE 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 228 AREISNVNVYNFIkDKNKLADLYRESTFILLPSkrtpFWEElFGMVLIEAMACGCIPLCTDHNGPSIILGHST--LKINV 305
Cdd:cd03801   244 LGLGDRVRFLGFV-PDEELPALYAAADVFVLPS----RYEG-FGLVVLEAMAAGLPVVATDVGGLPEVVEDGEggLVVPP 317

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 306 FSEDEYIQSVNAsfkkyqnqphlLVEDR-------INAIA-IAQKYSKESIADFWAAVIK 357
Cdd:cd03801   318 DDVEALADALLR-----------LLADPelrarlgRAARErVAERFSWERVAERLLDLYR 366
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 120-293 3.84e-21

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 93.04  E-value: 3.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 120 KKLILKW---WSFFLKHRVnsfAVVTETVKQQLVDNFNIDKSKIVVVYHS------YEsstfNVKTKNKNDKLKAIFVGR 190
Cdd:cd03808   125 LRLLYLLlekLALLFTDKV---IFVNEDDRDLAIKKGIIKKKKTVLIPGSgvdldrFQ----YSPESLPSEKVVFLFVAR 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 191 LVKEKGVDDLLAIAKI----NSEVEFIIVGEGPLSEHVKIEAREISNVNVYNFIKDKNKLADLYRESTFILLPSKRtpfw 266
Cdd:cd03808   198 LLKDKGIDELIEAAKIlkkkGPNVRFLLVGDGELENPSEILIEKLGLEGRIEFLGFRSDVPELLAESDVFVLPSYR---- 273

                         170       180
                  ....*....|....*....|....*..
gi 1142881326 267 eELFGMVLIEAMACGCIPLCTDHNGPS 293
Cdd:cd03808   274 -EGLPRSLLEAMAAGRPVITTDVPGCR 299
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 85-346 3.27e-20

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 90.50  E-value: 3.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326  85 RVFFFNRIL---KYSHVI-YHTSWTK--------------WDGSKYPKQYSFNKKLILKwwsFFLKHRVNSFAVVTETVK 146
Cdd:cd03811    71 AILKLKRILkraKPDVVIsFLGFATYivaklaaarskviaWIHSSLSKLYYLKKKLLLK---LKLYKKADKIVCVSKGIK 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 147 QQLVDNFNIDKSKIVVVYH--SYESSTFNVKTKNKNDKLKA---IFVGRLVKEKGVDDLL-AIAKI---NSEVEFIIVGE 217
Cdd:cd03811   148 EDLIRLGPSPPEKIEVIYNpiDIDRIRALAKEPILNEPEDGpviLAVGRLDPQKGHDLLIeAFAKLrkkYPDVKLVILGD 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 218 GPLSEHVKIEARE--ISN--------VNVYNFIKDknklADLYrestfiLLPSKRTPFweelfGMVLIEAMACGCIPLCT 287
Cdd:cd03811   228 GPLREELEKLAKElgLAErviflgfqSNPYPYLKK----ADLF------VLSSRYEGF-----PNVLLEAMALGTPVVST 292

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1142881326 288 DHNGPSIILGHSTLKI--NVFSEDEYIQSVNAsfkkyQNQPHLLVEDRINAIAIAQKYSKE 346
Cdd:cd03811   293 DCPGPREILDDGENGLlvPDGDAAALAGILAA-----LLQKKLDAALRERLAKAQEAVFRE 348
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 181-298 6.48e-20

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 85.40  E-value: 6.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 181 DKLKAIFVGRLVKEKGVDDLL-AIAKI---NSEVEFIIVGEGPLSEHVK--IEAREIS-NVNVYNFIKDKNkLADLYRES 253
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIkAFALLkekNPNLKLVIAGDGEEEKRLKklAEKLGLGdNVIFLGFVSDED-LPELLKIA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1142881326 254 TFILLPSKRtpfweELFGMVLIEAMACGCIPLCTDHNGPSIILGH 298
Cdd:pfam00534  80 DVFVLPSRY-----EGFGIVLLEAMACGLPVIASDVGGPPEVVKD 119
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 94-298 1.53e-19

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 88.18  E-value: 1.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326  94 KYSHVIYHTS--------WTKWDGSKYPKQY--SFNKKLILKWWSFFLKHRVNSFAVVTETVKQQLVDNFNIDKSKIVVV 163
Cdd:cd03819    76 RIDLIHAHSRapawlgwlASRLTGVPLVTTVhgSYLATYHPKDFALAVRARGDRVIAVSELVRDHLIEALGVDPERIRVI 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 164 YHSYESSTF--------NVKTKNKNDKLKAIFVGRLVKEKGVDDLL-AIAKINSE--VEFIIVGEGPLSEHVKIEAREIS 232
Cdd:cd03819   156 PNGVDTDRFppeaeaeeRAQLGLPEGKPVVGYVGRLSPEKGWLLLVdAAAELKDEpdFRLLVAGDGPERDEIRRLVERLG 235

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1142881326 233 ---NVNVYNFIKDknkLADLYRESTFILLPSKRtpfweELFGMVLIEAMACGCIPLCTDHNGPSIILGH 298
Cdd:cd03819   236 lrdRVTFTGFRED---VPAALAASDVVVLPSLH-----EEFGRVALEAMACGTPVVATDVGGAREIVVH 296
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
186-315 2.12e-19

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 83.33  E-value: 2.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 186 IFVGRLVKE-KGVDDLL-AIAKI---NSEVEFIIVGEGPLSEHVKIEAREISNVNVYNFIKDknkLADLYRESTFILLPS 260
Cdd:pfam13692   5 LFVGRLHPNvKGVDYLLeAVPLLrkrDNDVRLVIVGDGPEEELEELAAGLEDRVIFTGFVED---LAELLAAADVFVLPS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1142881326 261 KRtpfweELFGMVLIEAMACGCIPLCTDHNG-PSIILGHSTLKINVFSEDEYIQSV 315
Cdd:pfam13692  82 LY-----EGFGLKLLEAMAAGLPVVATDVGGiPELVDGENGLLVPPGDPEALAEAI 132
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 147-360 2.42e-19

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 88.21  E-value: 2.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 147 QQLVDNFNIDKSKIVVVYHSYESSTF---NVKTKNKNDKLKAIFVGRLVKEKGVDDLL-AIAKINSE---VEFIIVGEGP 219
Cdd:cd03798   162 AEELVALGVPRDRVDVIPNGVDPARFqpeDRGLGLPLDAFVILFVGRLIPRKGIDLLLeAFARLAKArpdVVLLIVGDGP 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 220 LSEHVKIEAREIS---NVNVYNFIkDKNKLADLYRESTFILLPSkrtpfWEELFGMVLIEAMACGCIPLCTDHNGPSIIL 296
Cdd:cd03798   242 LREALRALAEDLGlgdRVTFTGRL-PHEQVPAYYRACDVFVLPS-----RHEGFGLVLLEAMACGLPVVATDVGGIPEVV 315

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1142881326 297 GHSTLKINVfsEDEYIQSVNASFKKYQNQPHLLVEDRinaiAIAQKYSKESiaDFWAAVIKLAK 360
Cdd:cd03798   316 GDPETGLLV--PPGDADALAAALRRALAEPYLRELGE----AARARVAERF--SWVKAADRIAA 371
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 116-354 2.21e-18

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 84.98  E-value: 2.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 116 YSFNKKLILKWWSFFLKHR-VNSFAVVTETVKQqlvDNFNIDKSKIVVVYHSYESSTFNVKTKNKNDKLkaIFVGRLVKE 194
Cdd:cd03820   119 YEAYNKGLRRLLLRRLLYKrADKIVVLTEADKL---KKYKQPNSNVVVIPNPLSFPSEEPSTNLKSKRI--LAVGRLTYQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 195 KGVDDLL----AIAKINSEVEFIIVGEGPLSEHV--KIEAREISN-VNVYNFIKDknkLADLYRESTFILLPSKrtpfWE 267
Cdd:cd03820   194 KGFDLLIeawaLIAKKHPDWKLRIYGDGPEREELekLIDKLGLEDrVKLLGPTKN---IAEEYANSSIFVLSSR----YE 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 268 ElFGMVLIEAMACGCIPLCTDHN-GPSIILGHstlkinvfSEDEY-IQSVNASfkKYQNQPHLLVED---RI----NAIA 338
Cdd:cd03820   267 G-FPMVLLEAMAYGLPIISFDCPtGPSEIIED--------GENGLlVPNGDVD--ALAEALLRLMEDeelRKkmgkNARK 335

                         250
                  ....*....|....*.
gi 1142881326 339 IAQKYSKESIADFWAA 354
Cdd:cd03820   336 NAERFSIEKIIKQWEE 351
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 159-292 1.59e-17

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 80.91  E-value: 1.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 159 KIVVVYHSYESSTFNVKTKNKNDKLK-------AIFVGRLVKEKGVDDLL-AIAKINSE---VEFIIVGEGPLS---EHV 224
Cdd:cd01635    80 PIVVTVHGPDSLESTRSELLALARLLvslpladKVSVGRLVPEKGIDLLLeALALLKARlpdLVLVLVGGGGEReeeEAL 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1142881326 225 KIEAREISNVNVYNFIKDKNKLADLYRESTFILLPSKRTPFweelfGMVLIEAMACGCIPLCTDHNGP 292
Cdd:cd01635   160 AAALGLLERVVIIGGLVDDEVLELLLAAADVFVLPSRSEGF-----GLVLLEAMAAGKPVIATDVGGI 222
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 127-338 1.98e-17

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 82.38  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 127 WSFFLKHRVNSFAVVTETVKQQLVDNFnIDKSKIVVVYHSYESSTF-NVKTKNKNDKLKAIFVGRLVKEKGVDDLLAIAK 205
Cdd:cd03823   136 RQFLFKKGGDAVLAPSRFTANLHEANG-LFSARISVIPNAVEPDLApPPRRRPGTERLRFGYIGRLTEEKGIDLLVEAFK 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 206 --INSEVEFIIVGEGPLSEHVKIEARE----ISNVnvynfikDKNKLADLYRESTFILLPSKrtpfWEELFGMVLIEAMA 279
Cdd:cd03823   215 rlPREDIELVIAGHGPLSDERQIEGGRriafLGRV-------PTDDIKDFYEKIDVLVVPSI----WPEPFGLVVREAIA 283

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1142881326 280 CGCIPLCTDHNGPSIILGHSTLKInVFSEDEyIQSVNASFKKYQNQPHLLVEDRINAIA 338
Cdd:cd03823   284 AGLPVIASDLGGIAELIQPGVNGL-LFAPGD-AEDLAAAMRRLLTDPALLERLRAGAEP 340
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 111-354 3.06e-17

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 82.03  E-value: 3.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 111 KYPKQYSFNKKLILKWWSFFLKHRVNSFAVVTETVKQQLVDNFNIDKSKIVVVYHSYESSTFNVKTKNKNDKLKAI---- 186
Cdd:cd03809   115 RYPEFFPKRFRLYYRLLLPISLRRADAIITVSEATRDDIIKFYGVPPEKIVVIPLGVDPSFFPPESAAVLIAKYLLpepy 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 187 --FVGRLVKEKGVDDLLAIAKI----NSEVEFIIVGE-GPLSEHVKIEAREI---SNVNVYNFIkDKNKLADLYRESTFI 256
Cdd:cd03809   195 flYVGTLEPRKNHERLLKAFALlkkqGGDLKLVIVGGkGWEDEELLDLVKKLglgGRVRFLGYV-SDEDLPALYRGARAF 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 257 LLPSKRtpfweELFGMVLIEAMACGCIPLCTdhNGPSI--ILGHSTLKINVFSedeyIQSVNASFKKYQNQPHLLVEDRI 334
Cdd:cd03809   274 VFPSLY-----EGFGLPVLEAMACGTPVIAS--NISVLpeVAGDAALYFDPLD----PESIADAILRLLEDPSLREELIR 342

                         250       260
                  ....*....|....*....|
gi 1142881326 335 NAIAIAQKYSKESIADFWAA 354
Cdd:cd03809   343 KGLERAKKFSWEKTAEKTLE 362
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 100-282 5.62e-15

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 75.39  E-value: 5.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 100 YHTSWtkwdgSKYPKQYSFNKKLI---LKWWSFFLKHRVNSFAVVTETVKQQLVdNFNIDKSKIVV-------VYHSYES 169
Cdd:cd03817   115 YHTMY-----EDYLHYIPKGKLLVkavVRKLVRRFYNHTDAVIAPSEKIKDTLR-EYGVKGPIEVIpngidldKFEKPLN 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 170 STFNVKTKNKNDKLKAIFVGRLVKEKGVDDLL-AIAKINSE--VEFIIVGEGPLSEHVKIEAREI---SNVNVYNFIKDk 243
Cdd:cd03817   189 TEERRKLGLPPDEPILLYVGRLAKEKNIDFLLrAFAELKKEpnIKLVIVGDGPEREELKELARELglaDKVIFTGFVPR- 267

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1142881326 244 NKLADLYRESTFILLPSKrtpfwEELFGMVLIEAMACGC 282
Cdd:cd03817   268 EELPEYYKAADLFVFAST-----TETQGLVYLEAMAAGL 301
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 140-296 5.61e-14

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 72.27  E-value: 5.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 140 VVTETV--KQQLVDNFNIDKSKIVVVYHSYESSTFNVKTK---------NKNDKLKAIFVGRLVKEKGVDDLL-AIAKI- 206
Cdd:cd03800   167 VIASTPqeADELISLYGADPSRINVVPPGVDLERFFPVDRaearrarllLPPDKPVVLALGRLDPRKGIDTLVrAFAQLp 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 207 --NSEVEFIIVG--EGPLSEHVKIEAREI----SNVNVYNFIK--DKNKLADLYRESTFILLPSkrtpfWEELFGMVLIE 276
Cdd:cd03800   247 elRELANLVLVGgpSDDPLSMDREELAELaeelGLIDRVRFPGrvSRDDLPELYRAADVFVVPS-----LYEPFGLTAIE 321

                         170       180
                  ....*....|....*....|
gi 1142881326 277 AMACGCIPLCTDHNGPSIIL 296
Cdd:cd03800   322 AMACGTPVVATAVGGLQDIV 341
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 97-299 8.15e-13

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 68.86  E-value: 8.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326  97 HVIYHTSWtkwdgSKYPKQY--SFNKKLILKWWSFFlkHRVNSFAVV-TETVKQQLVdnfNIDKSKIVVVYHSYESSTFN 173
Cdd:cd03814   112 VTSYHTDF-----PEYLSYYtlGPLSWLAWAYLRWF--HNPFDTTLVpSPSIARELE---GHGFERVRLWPRGVDTELFH 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 174 VKTKNK--------NDKLKAIFVGRLVKEKGVDDLL-AIAKINSE--VEFIIVGEGPLSEHVkieAREISNVnVYNFIKD 242
Cdd:cd03814   182 PSRRDAalrrrlgpPGRPLLLYVGRLAPEKNLEALLdADLPLAASppVRLVVVGDGPARAEL---EARGPDV-IFTGFLT 257

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1142881326 243 KNKLADLYRESTFILLPSkRTpfweELFGMVLIEAMACGCIPLCTDHNGPSIILGHS 299
Cdd:cd03814   258 GEELARAYASADVFVFPS-RT----ETFGLVVLEAMASGLPVVAADAGGPRDIVRPG 309
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 122-300 1.16e-12

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 68.11  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 122 LILKWWSFFLKHRV-NSFAVVTETVKQqlvdnfNIDKSKIVVVYHSYESSTFNVKTKNKNDKLKAIF----------VGR 190
Cdd:cd03807   125 KLCLLLSKFSPATVaNSSAVAEFHQEQ------GYAKNKIVVIYNGIDLFKLSPDDASRARARRRLGlaedrrvigiVGR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 191 LVKEKGVDDLL-AIAKINSE---VEFIIVGEGPLSEHVKIEAREISNVNVYNFIKDKNKLADLYRESTFILLPSKrtpfw 266
Cdd:cd03807   199 LHPVKDHSDLLrAAALLVEThpdLRLLLVGRGPERPNLERLLLELGLEDRVHLLGERSDVPALLPAMDIFVLSSR----- 273

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1142881326 267 EELFGMVLIEAMACGcIP-LCTDHNGPSIILGHST 300
Cdd:cd03807   274 TEGFPNALLEAMACG-LPvVATDVGGAAELVDDGT 307
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 134-352 1.55e-12

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 67.71  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 134 RVNSFAVVTETVKQQLVDNFNIDKsKIVVVYHSYESSTFNVKTKNKNDKLKAIFVGRLVKEKGVDDLL-AIAKIN---SE 209
Cdd:cd04949   113 KYDAIIVSTEQQKQDLSERFNKYP-PIFTIPVGYVDQLDTAESNHERKSNKIITISRLAPEKQLDHLIeAVAKAVkkvPE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 210 VEFIIVGEGPLSEHVKIEAREISNVNVYNFIKDKNKLADLYRESTFILLPSKrtpfwEELFGMVLIEAMACGCIPLCTDH 289
Cdd:cd04949   192 ITLDIYGYGEEREKLKKLIEELHLEDNVFLKGYHSNLDQEYQDAYLSLLTSQ-----MEGFGLTLMEAIGHGLPVVSYDV 266

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1142881326 290 N-GPS--IILGHSTLKInvfsEDEYIQSVNASFKKYQNQPHLLVEDRINAIAIAQKYSKESIADFW 352
Cdd:cd04949   267 KyGPSelIEDGENGYLI----EKNNIDALADKIIELLNDPEKLQQFSEESYKIAEKYSTENVMEKW 328
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 153-281 5.01e-12

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 66.14  E-value: 5.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 153 FNIDKSKIVVVYHSYEsstfNVKTKNKNDKLkAIFVGRLVKEKGVDDLL-AIAKINSEVefIIVGEGPLSEHVK--IEAR 229
Cdd:cd03795   167 LGIDKNVYNIPRVDFE----NIKREKKGKKI-FLFIGRLVYYKGLDYLIeAAQYLNYPI--VIGGEGPLKPDLEaqIELN 239

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1142881326 230 EISNVNVYNFIKDKNKlADLYRESTFILLPS-KRTpfweELFGMVLIEAMACG 281
Cdd:cd03795   240 LLDNVKFLGRVDDEEK-VIYLHLCDVFVFPSvLRS----EAFGIVLLEAMMCG 287
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 118-353 9.71e-12

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 65.44  E-value: 9.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 118 FNKKLILKWWSFFLK---HRVNSFAVVTETVKQQLVdNFNIDKSKIVVVYHSYESSTFN-------VKTKNKNDKLKAIF 187
Cdd:cd03794   144 LKKGSLLKLLKKLERklyRLADAIIVLSPGLKEYLL-RKGVPKEKIIVIPNWADLEEFKpppkdelRKKLGLDDKFVVVY 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 188 VGRLVKEKGVDDLLAIAKI---NSEVEFIIVGEGPLSEHVK--IEAREISNVNVYNFIkDKNKLADLYRESTFILLPSKR 262
Cdd:cd03794   223 AGNIGKAQGLETLLEAAERlkrRPDIRFLFVGDGDEKERLKelAKARGLDNVTFLGRV-PKEEVPELLSAADVGLVPLKD 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 263 TPFWEELFGMVLIEAMACGcIP-LCTDHNGPSIIlghstLKIN---VFSEDEYIQSVNASFKKYQNQPHLLVEDRINA-I 337
Cdd:cd03794   302 NPANRGSSPSKLFEYMAAG-KPiLASDDGGSDLA-----VEINgcgLVVEPGDPEALADAILELLDDPELRRAMGENGrE 375

                         250
                  ....*....|....*.
gi 1142881326 338 AIAQKYSKESIADFWA 353
Cdd:cd03794   376 LAEEKFSREKLADRLL 391
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 114-350 2.21e-11

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 64.31  E-value: 2.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 114 KQYSFNKKLIlkWWSFFLKHRVNSFAVVTETVKQQL--VDNFNIdKSKIVVVYHSYESSTF-----NVKTKNKNDKLKAI 186
Cdd:cd03821   131 LQQKHWKKRI--ALHLIERRNLNNAALVHFTSEQEAdeLRRFGL-EPPIAVIPNGVDIPEFdpglrDRRKHNGLEDRRII 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 187 -FVGRLVKEKGVDDLL-AIAKINSE---VEFIIVGEGPLSEHVkiEAREISNVNV------YNFIKDKNKLADLYRESTF 255
Cdd:cd03821   208 lFLGRIHPKKGLDLLIrAARKLAEQgrdWHLVIAGPDDGAYPA--FLQLQSSLGLgdrvtfTGPLYGEAKWALYASADLF 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 256 ILlPSKRtpfweELFGMVLIEAMACGCIPLCTDH-NGPSIILGHSTLKinVFSEDEYIQSVNASFKKYQNQPHLLVEDRI 334
Cdd:cd03821   286 VL-PSYS-----ENFGNVVAEALACGLPVVITDKcGLSELVEAGCGVV--VDPNVSSLAEALAEALRDPADRKRLGEMAR 357

                         250
                  ....*....|....*.
gi 1142881326 335 NAIAIAQKYSKESIAD 350
Cdd:cd03821   358 RARQVEENFSWEAVAG 373
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 126-291 4.93e-10

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 60.16  E-value: 4.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 126 WWSFFLKHR------VNSFAVVTETVKQQLVDNfNIDKSKIVVVYHSYESSTFNVKTKnKNDKLKAIFVGRLVKEKGVDD 199
Cdd:cd05844   129 WPSQFQRHRralqrpAALFVAVSGFIRDRLLAR-GLPAERIHVHYIGIDPAKFAPRDP-AERAPTILFVGRLVEKKGCDV 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 200 LLA----IAKINSEVEFIIVGEGPLSEHVKIEAREISNVNvYNFIKDKNKLADLYRESTFILLPSKRTPFWE-ELFGMVL 274
Cdd:cd05844   207 LIEafrrLAARHPTARLVIAGDGPLRPALQALAAALGRVR-FLGALPHAEVQDWMRRAEIFCLPSVTAASGDsEGLGIVL 285

                         170
                  ....*....|....*..
gi 1142881326 275 IEAMACGCIPLCTDHNG 291
Cdd:cd05844   286 LEAAACGVPVVSSRHGG 302
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 141-291 2.12e-09

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 58.52  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 141 VTETVKQQLVDNFNIDKsKIVVVYHSYESSTFNVKTKN--------KNDKLKAIFVGRLVKEKGVDDLLAI-AKINSEV- 210
Cdd:cd04962   148 VSSSLRQETYELFDVDK-DIEVIHNFIDEDVFKRKPAGalkrrllaPPDEKVVIHVSNFRPVKRIDDVVRVfARVRRKIp 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 211 -EFIIVGEGPLSEHVKIEAREISNVNVYNFIKDKNKLADLYRESTFILLPSKRtpfweELFGMVLIEAMACGCIPLCTDH 289
Cdd:cd04962   227 aKLLLVGDGPERVPAEELARELGVEDRVLFLGKQDDVEELLSIADLFLLPSEK-----ESFGLAALEAMACGVPVVSSNA 301


                  ..
gi 1142881326 290 NG 291
Cdd:cd04962   302 GG 303
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 249-357 3.33e-09

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 54.23  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 249 LYRESTFILLPSkrtpfWEELFGMVLIEAMACGCIPLCTDHNGPS--IILGHSTLKINVFSEDEYIQSVNasfkKYQNQP 326
Cdd:COG0438    17 LLAAADVFVLPS-----RSEGFGLVLLEAMAAGLPVIATDVGGLPevIEDGETGLLVPPGDPEALAEAIL----RLLEDP 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1142881326 327 HLLVEDRINAIAIAQ-KYSKESIADFWAAVIK 357
Cdd:COG0438    88 ELRRRLGEAARERAEeRFSWEAIAERLLALYE 119
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 174-305 9.83e-09

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 56.14  E-value: 9.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 174 VKTKNKNDKLKAIFVGRLVKEKGVDDLLAIA----KINSEVEFIIVGEGPLSEHVKIEAREISNVNVYNFIKDKNKLADL 249
Cdd:cd03812   183 RKLLILEDKLVLGHVGRFNEQKNHSFLIDIFeelkKKNPNVKLVLVGEGELKEKIKEKVKELGLEDKVIFLGFRNDVSEI 262

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1142881326 250 YRESTFILLPSkrtpFWEELfGMVLIEAMACGCIPLCTDHNGPSIILGHST--LKINV 305
Cdd:cd03812   263 LSAMDVFLFPS----LYEGL-PLVAVEAQASGLPCLLSDTITKECDITNNVefLPLNE 315
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 141-291 1.16e-08

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 55.91  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 141 VTETVKQQLVDNF----NIDKSKIVVVYHSYESSTFN------VKTKNK----NDKLKAIFVGRLVKEKG-VDDLLAIAK 205
Cdd:cd04951   133 ITTNVSREALDEFiakkAFSKNKSVPVYNGIDLNKFKkdinvrLKIRNKlnlkNDEFVILNVGRLTEAKDyPNLLLAISE 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 206 ---INSEVEFIIVGEGPLSEHVKieaREISNVNVYN---FIKDKNKLADLYRESTFILLPSKrtpfWEElFGMVLIEAMA 279
Cdd:cd04951   213 lilSKNDFKLLIAGDGPLRNELE---RLICNLNLVDrviLLGQISNISEYYNAADLFVLSSE----WEG-FGLVVAEAMA 284

                         170
                  ....*....|..
gi 1142881326 280 CGCIPLCTDHNG 291
Cdd:cd04951   285 CERPVVATDAGG 296
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 162-282 8.51e-07

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 49.98  E-value: 8.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 162 VVYHSYESSTFNVKTKNKNDklkAIFVGRLVKEKGVDDLLAIAKiNSEVEFIIVGEGPLSEHV-KIEAREI-SNVNVYNF 239
Cdd:cd03802   152 VVHNGLDPADYRFQPDPEDY---LAFLGRIAPEKGLEDAIRVAR-RAGLPLKIAGKVRDEDYFyYLQEPLPgPRIEFIGE 227

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1142881326 240 IkDKNKLADLYRESTFILLPSKrtpfWEELFGMVLIEAMACGC 282
Cdd:cd03802   228 V-GHDEKQELLGGARALLFPIN----WDEPFGLVMIEAMACGT 265
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
140-283 9.79e-07

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 50.09  E-value: 9.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 140 VVTETVKQQLVdNFNIDKSKIVVVYHSYESSTFNVKTKNKNDKLKAIFVGRLV--KEKGVDDLL-AIAKINSEVEFIIVG 216
Cdd:PRK09922  139 AISSGIKEQMM-ARGISAQRISVIYNPVEIKTIIIPPPERDKPAVFLYVGRLKfeGQKNVKELFdGLSQTTGEWQLHIIG 217

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1142881326 217 EGPLSEHVKIEARE--ISN--------VNVYNFIKDKNKladlyrESTFILLPSKRtpfweELFGMVLIEAMACG--CI 283
Cdd:PRK09922  218 DGSDFEKCKAYSRElgIEQriiwhgwqSQPWEVVQQKIK------NVSALLLTSKF-----EGFPMTLLEAMSYGipCI 285
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 138-291 1.10e-06

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 49.76  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 138 FAVVTETVKQQLVdNFNIDKSKIVVVYHSYESSTFNVKTKN--KNDKLKAIFVGRLVKEKGVD-DLLAIAKINSE---VE 211
Cdd:cd03799   129 FLPNCELFKHRLI-ALGCDEKKIIVHRSGIDCNKFRFKPRYlpLDGKIRILTVGRLTEKKGLEyAIEAVAKLAQKypnIE 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 212 FIIVGEGPLSEHVKieaREISNVNVYNFI-----KDKNKLADLYRESTFILLPSKRTPFW-EELFGMVLIEAMACGCIPL 285
Cdd:cd03799   208 YQIIGDGDLKEQLQ---QLIQELNIGDCVkllgwKPQEEIIEILDEADIFIAPSVTAADGdQDGPPNTLKEAMAMGLPVI 284


                  ....*.
gi 1142881326 286 CTDHNG 291
Cdd:cd03799   285 STEHGG 290
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 124-281 1.22e-06

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 49.59  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 124 LKWWSFFLKHRVNSFAVVTETVKQQLVDNFNIDKSkivVVYHSYESSTFNVKTKNKNDKLKAifvGRLVKEKGVDdlLAI 203
Cdd:cd03804   147 LRLWDVRTAQRVDLFIANSQFVARRIKKFYGREST---VIYPPVDTDAFAPAADKEDYYLTA---SRLVPYKRID--LAV 218

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1142881326 204 -AKINSEVEFIIVGEGPLSEhvKIEAREISNVNVYNFIKDkNKLADLYRESTFILLPSkrtpfwEELFGMVLIEAMACG 281
Cdd:cd03804   219 eAFNELPKRLVVIGDGPDLD--RLRAMASPNVEFLGYQPD-EVLKELLSKARAFVFAA------EEDFGIVPVEAQACG 288
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 195-299 5.29e-06

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 47.71  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 195 KGVDDLL-AIAKINSEVEFIIVGEGPLSEHvkieaREISNVNVYNF--IKDKNKLADLYRESTFILLPSKrtpfwEELFG 271
Cdd:cd03825   208 KGFDELIeALKLLATKDDLLLVVFGKNDPQ-----IVILPFDIISLgyIDDDEQLVDIYSAADLFVHPSL-----ADNLP 277

                          90       100
                  ....*....|....*....|....*...
gi 1142881326 272 MVLIEAMACGCIPLCTDHNGPSIILGHS 299
Cdd:cd03825   278 NTLLEAMACGTPVVAFDTGGSPEIVQHG 305
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 141-281 7.56e-06

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 47.23  E-value: 7.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 141 VTETVKQQLVDNFNIDKSKIVVVYHSYESSTFNVK-TKNKNDKLKAIFVGRLVKEKGVdDLLA-----IAKINSEVEFII 214
Cdd:cd03796   151 VSHTSKENTVLRASLDPRIVSVIPNAVDSSDFTPDpSKPDPNKITIVVISRLVYRKGI-DLLVgiiprICKKHPNVRFII 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 215 VGEGP-------------LSEHVK----IEAREISNVNVynfikdknkladlyreSTFILLPSKRTpfweELFGMVLIEA 277
Cdd:cd03796   230 GGDGPkrieleemrekyqLQDRVEllgaVPHEEVRDVLV----------------QGHIFLNTSLT----EAFCIAIVEA 289


                  ....
gi 1142881326 278 MACG 281
Cdd:cd03796   290 ASCG 293
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 187-285 3.83e-05

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 45.25  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 187 FVGRLVKEKGVDDLLAIAK--INSEVEFIIVGEG-PLSEHVKIEAREISNVNVYNFIKDKNKLAD-LYRESTFILLPSKr 262
Cdd:cd03791   299 FVGRLTEQKGVDLILDALPelLEEGGQLVVLGSGdPEYEQAFRELAERYPGKVAVVIGFDEALAHrIYAGADFFLMPSR- 377

                          90       100
                  ....*....|....*....|...
gi 1142881326 263 tpFweELFGMVLIEAMACGCIPL 285
Cdd:cd03791   378 --F--EPCGLVQMYAMRYGTLPI 396
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 112-281 6.51e-05

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 44.70  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 112 YPKQYSFNKkLILKWWSF--FLkHRVNSFAVVTET-VKQQLVDNFNIDKSKIVVVYHSYESSTFNVK----------TKN 178
Cdd:PLN02871  182 YIPRYTFSW-LVKPMWDIirFL-HRAADLTLVTSPaLGKELEAAGVTAANRIRVWNKGVDSESFHPRfrseemrarlSGG 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 179 KNDKLKAIFVGRLVKEKGVDDLLAIAKINSEVEFIIVGEGPLSEHVKiEAREISNVnVYNFIKDKNKLADLYRESTFILL 258
Cdd:PLN02871  260 EPEKPLIVYVGRLGAEKNLDFLKRVMERLPGARLAFVGDGPYREELE-KMFAGTPT-VFTGMLQGDELSQAYASGDVFVM 337

                         170       180
                  ....*....|....*....|...
gi 1142881326 259 PSKrtpfwEELFGMVLIEAMACG 281
Cdd:PLN02871  338 PSE-----SETLGFVVLEAMASG 355
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
100-165 5.00e-04

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 40.21  E-value: 5.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1142881326 100 YHTSWTKWDGSKYPKQYsfnKKLILKWWSFFLKHRVNSFAVVTETVKQQLVDNFNIDKSKIVVVYH 165
Cdd:pfam13439 102 YHGLFPDYKRLGARLSP---LRRLLRRLERRLLRRADRVIAVSEAVADELRRLYGVPPEKIRVIPN 164
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
 266-292 9.02e-03

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 37.97  E-value: 9.02e-03
                          10        20
                  ....*....|....*....|....*..
gi 1142881326 266 WEELFGMVLIEAMACGCIPLCTDHNGP 292
Cdd:cd03806   333 WNEHFGIGVVEYMAAGLIPLAHASAGP 359
GlgA COG0297
Glycogen synthase [Carbohydrate transport and metabolism];
164-285 9.21e-03

Glycogen synthase [Carbohydrate transport and metabolism];


Pssm-ID: 440066 [Multi-domain]  Cd Length: 476  Bit Score: 37.76  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1142881326 164 YHSYESSTFNVKTKNK------------NDKLKAIFVGRLVKEKGVDDLLAIAK--INSEVEFIIVGEGplsEHvKIEA- 228
Cdd:COG0297   265 PANYSADDLEGKAANKaalqeelglpvdPDAPLIGMVSRLTEQKGLDLLLEALDelLEEDVQLVVLGSG---DP-EYEEa 340

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1142881326 229 -REIS-----NVNVYnfIKDKNKLADL-YRESTFILLPSKrtpFweELFGMVLIEAMACGCIPL 285
Cdd:COG0297   341 fRELAarypgRVAVY--IGYDEALAHRiYAGADFFLMPSR---F--EPCGLNQMYALRYGTVPI 397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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